D:Arthropathy

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Disease Term
Synonyms Arthropathic, Arthropathies, ARTHROSIS, Articular Disease, Disease Joint, Diseases Joint, JOINT DISEASE, Joint Diseases, JOINT DISORDER, Joint Disorders, Joint Dysfunction
Documents 3725
Hot Single Events 200
Hot Interactions 30

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Arthropathy. They are ordered first by their relevance to Arthropathy and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT201943 Regulation of Binding of DPP4 and CXCL10 1 0.20 0.58 0.42 100.00
2 INT301285 Binding of Tyrobp and Clec5a 1 0.32 1.63 0.49 99.76
3 INT107965 Binding of HLA-B and Mefv 2 0.34 3.91 1.61 99.16
4 INT248310 Crx Regulation of MATN3 1 0.07 0.65 0.45 99.16
5 INT115356 Binding of HLA-G and ATP8A1 1 0.00 0.52 0.15 98.60
6 INT59166 Binding of fc and IgG 2 0.00 1.23 0.17 98.48
7 INT289249 Il6 Regulation of Gene_expression of Ptger2 1 0.01 0.77 0.1 97.72
8 INT134993 P2rx6 Regulation of Ephb1 1 0.20 1.27 0.87 96.48
9 INT60063 IL1B Regulation of NPEPPS 1 0.00 0.29 0.42 96.24
10 INT201948 Binding of DPP4 and CXCL10 1 0.27 0.54 0.39 95.20
11 INT302820 Stat3 Regulation of Positive_regulation of Il7 1 0.04 1.03 0.49 94.12
12 INT302823 Stat3 Regulation of Gene_expression of Il7 1 0.04 1.03 0.49 93.72
13 INT229785 Binding of RAB7A and SPTLC1 1 0.40 1.5 0.27 92.68
14 INT289252 Il6 Negative_regulation of Tnfrsf11a 1 0.11 0.82 0.04 92.68
15 INT346225 Binding of PRTN3 and Flg 1 0.01 1.74 0.69 91.52
16 INT346227 Binding of PRTN3 and Vim 1 0.01 0.93 0.38 91.52
17 INT300545 Il6 Positive_regulation of Gene_expression of Il1r1 1 0.02 0.42 0.11 91.28
18 INT187116 TIMP2 Negative_regulation of MMP9 1 0.36 1.37 0.5 89.20
19 INT187117 Negative_regulation of TIMP2 Negative_regulation of MMP9 1 0.36 0.6 0.22 89.20
20 INT131156 Binding of RUNX1 and TNF 2 0.03 3.44 1.42 88.20
21 INT298584 IL1B Regulation of Gene_expression of TNFRSF11B 1 0.22 0.7 0.4 87.36
22 INT187111 TIMP2 Regulation of MMP9 1 0.23 1.47 0.97 87.20
23 INT169570 Binding of ROS1 and TRPV1 3 0.33 3.07 1.89 86.56
24 INT301290 Tnfsf11 Positive_regulation of Nfatc1 1 0.15 0.65 0.2 85.08
25 INT301282 Tnfsf11 Positive_regulation of Traf6 1 0.10 0.65 0.2 85.08
26 INT220051 Fcgr4 Positive_regulation of Gene_expression of Ido1 1 0.01 1.24 0.55 82.40
27 INT172048 Binding of TNF and MICA 1 0.29 1.63 0.62 82.32
28 INT19645 Binding of HLA-B and KLRD1 1 0.00 0.73 0.15 82.24
29 INT299745 Binding of Masp1 and IgG 1 0.03 0.69 0.26 80.64
30 INT171250 Binding of BMI1 and OAP 1 0.13 1.02 0.22 80.48
31 INT302834 Cd4 Positive_regulation of Gene_expression of Il7 1 0.05 1.02 0.54 79.80
32 INT184094 Gene_expression of Socs3 Negative_regulation of Positive_regulation of Il6 1 0.12 1.49 0.48 79.52
33 INT298588 IL1B Regulation of Gene_expression of CSF1 1 0.35 0.59 0.36 78.24
34 INT182097 Binding of Il6 and Il1 4 0.07 4.67 1.55 78.04
35 INT300546 Binding of Il23a and Il1 1 0.01 0.5 0.25 78.04
36 INT184191 IL1B Positive_regulation of Gene_expression of SPAM1 1 0.03 0.59 0.23 77.20
37 INT192293 Binding of IGF1 and IL1B 1 0.15 0.08 0.08 75.92
38 INT178576 CNTN2 Positive_regulation of DPYD 1 0.05 2.18 0.76 75.84
39 INT153620 Binding of Ntrk1 and WNK1 1 0.02 0.85 0.12 75.76
40 INT299783 Binding of Cd28 and Cd80 7 0.14 6.49 2.49 75.72
41 INT279410 Binding of MTRF1 and IGKV2-19 1 0.00 0.63 0.15 75.48
42 INT279408 Binding of CRYGD and IGKV2-19 1 0.00 0.4 0.1 75.48
43 INT279409 Binding of CRP and IGKV2-19 1 0.02 0.4 0.1 75.48
44 INT279407 Binding of ESR1 and IGKV2-19 1 0.02 0.4 0.1 75.48
45 INT301292 Negative_regulation of Clec5a Negative_regulation of TNF 1 0.05 1.04 0.27 75.36
46 INT178579 CNTN2 Positive_regulation of IL6 1 0.07 2.17 0.75 75.20
47 INT178577 CNTN2 Positive_regulation of IL2RA 1 0.03 2.16 0.75 74.72
48 INT240057 Binding of RHOB and NME8 1 0.41 4.11 1.5 74.40
49 INT13538 ASPRV1 Negative_regulation of Gene_expression of LTA 1 0.46 0.56 0.25 74.28
50 INT178581 CNTN2 Positive_regulation of PTHLH 1 0.24 2.16 0.75 74.08
51 INT178575 CNTN2 Positive_regulation of PTHLH Positive_regulation of Positive_regulation of PTHLH 1 0.26 2.16 0.75 74.08
52 INT192292 OR5A1 Negative_regulation of IL1B 1 0.01 0.15 0 73.44
53 INT300549 Il1 Regulation of Gene_expression of Irf4 1 0.01 0.63 0.33 72.60
54 INT184292 Binding of AGER and chromosomal protein 1 1 0.01 0.87 0.41 72.40
55 INT333499 Binding of IGHE and PHB2 1 0.14 4.08 0.95 72.20
56 INT301284 Tnfsf11 Positive_regulation of Localization of Nfatc1 1 0.16 0.32 0.11 68.88
57 INT302845 Il7 Positive_regulation of Gene_expression of TNF 1 0.01 0.98 0.49 68.40
58 INT182325 TP53 Negative_regulation of Transcription of Birc5 1 0.01 1.34 0.26 68.40
59 INT182326 LBR Positive_regulation of Gene_expression of Birc5 1 0.00 0.46 0.17 68.12
60 INT176479 IL17A Positive_regulation of Gene_expression of TIMP1 1 0.02 1.33 0.74 68.08
61 INT301289 Positive_regulation of Clec5a Positive_regulation of Gene_expression of Atp6v0d2 1 0.02 1.01 0.28 68.00
62 INT220243 IL1RN Negative_regulation of Gene_expression of DPEP1 1 0.20 0.22 0.19 67.44
63 INT197051 Binding of HLA-E and ATP8A1 1 0.00 6.52 1.14 67.24
64 INT331881 F2 Positive_regulation of F8 1 0.10 0.53 0.03 67.00
65 INT186123 Binding of GIF and IL10 1 0.23 1.17 0.69 66.88
66 INT331627 Binding of HLA-DRB3 and Pain1 1 0.00 2.15 0.14 66.80
67 INT188692 Binding of Cd40 and Cd40lg 32 0.34 22.95 6.62 66.68
68 INT135180 IL1B Positive_regulation of Gene_expression of TNFSF11 2 0.76 1.73 0.75 66.00
69 INT201949 CXCL10 Positive_regulation of Phosphorylation of MAPK1 1 0.15 0.79 0.55 65.96
70 INT201944 CXCL10 Positive_regulation of Phosphorylation of AKT1 1 0.09 0.79 0.55 65.96
71 INT201939 CXCL10 Positive_regulation of MAPK1 1 0.11 0.72 0.52 65.96
72 INT187110 Binding of TIMP2 and GOPC 1 0.07 0.64 0.29 65.76
73 INT187107 Binding of IGHG3 and TIMP2 1 0.01 0.62 0.28 65.76
74 INT331628 Binding of HLA-DQA2 and Pain1 1 0.01 2.13 0.14 65.52
75 INT205705 Positive_regulation of P2rx7 Positive_regulation of Gene_expression of Il6 1 0.07 1.42 0.58 65.32
76 INT284307 Mir155 Regulation of Adrb3 1 0.00 3.44 0.73 63.52
77 INT141016 Il18 Positive_regulation of Gene_expression of Ifng 1 0.39 0.27 0.39 62.88
78 INT164415 Tgfb1 Regulation of Crlf1 1 0.01 0.78 0.45 61.44
79 INT201941 IFNA1 Positive_regulation of Gene_expression of CXCL10 1 0.14 1.09 0.74 58.96
80 INT201947 IFNA1 Positive_regulation of Gene_expression of DPP4 1 0.11 1.09 0.74 57.92
81 INT224410 Binding of CRP and CIMT 3 0.42 10.46 1.2 57.76
82 INT307765 Myoz1 Positive_regulation of Gene_expression of Il6 1 0.01 0.71 0.21 57.52
83 INT307764 Myoz1 Positive_regulation of Transcription of Il6 1 0.01 0.72 0.21 57.52
84 INT201950 IFNA1 Positive_regulation of Binding of DPP4 1 0.12 2.17 1.47 57.00
85 INT201946 IFNA1 Positive_regulation of DPP4 1 0.17 2.16 1.46 56.76
86 INT289247 Ptger2 Positive_regulation of Gene_expression of Tnfrsf11a 1 0.00 0.76 0.14 56.40
87 INT306745 Binding of Il12a and IL23A 1 0.10 3.25 1.56 55.80
88 INT301288 Clec5a Regulation of Nfatc1 1 0.21 0.25 0.1 55.20
89 INT220054 Regulation of IFN1@ Negative_regulation of Cia1 1 0.18 1.19 0.52 52.00
90 INT186355 Il23a Positive_regulation of Gene_expression of Il17a 4 0.12 3 1.24 51.84
91 INT348924 Mmp1 Regulation of Gene_expression of Renbp 1 0.03 0.95 0.26 50.84
92 INT289245 Binding of Il6ra and Positive_regulation of Gene_expression of Ptger2 1 0.00 0.82 0.15 50.72
93 INT220055 IFN1@ Negative_regulation of Cia1 1 0.24 1.12 0.48 50.32
94 INT101942 Binding of CD40 and CD40LG 16 0.23 15.24 4.01 49.88
95 INT264382 NR1H4 Positive_regulation of VDR 1 0.04 0.09 0.03 48.48
96 INT264396 NR1H4 Positive_regulation of THRA 1 0.01 0.09 0.03 48.48
97 INT301278 Nfatc1 Regulation of Acp5 1 0.05 0.19 0.15 45.68
98 INT301283 Nfatc1 Regulation of Ctsk 1 0.06 0.19 0.13 45.68
99 INT346222 Positive_regulation of Braf Positive_regulation of Map2k1 1 0.15 0.67 0.39 44.56
100 INT346221 Positive_regulation of Braf Positive_regulation of Positive_regulation of Map2k2 1 0.11 0.67 0.39 44.56
101 INT346219 Positive_regulation of Braf Positive_regulation of Map2k2 1 0.11 0.67 0.39 44.56
102 INT201942 DPP4 Negative_regulation of CXCL10 1 0.33 0.9 1.3 44.12
103 INT231693 Binding of IGKV2-19 and BDNF-AS 1 0.00 2.39 0.81 44.08
104 INT352895 Positive_regulation of Binding of ROS1 and GOPC 1 0.08 0.68 0.26 42.12
105 INT171124 Spg7 Positive_regulation of NOSTRIN 1 0.01 0.76 0.24 42.04
106 INT352891 Binding of ROS1 and GOPC 1 0.09 1.34 0.53 41.80
107 INT171126 Lta Positive_regulation of NOSTRIN 1 0.01 0.76 0.24 41.72
108 INT240119 Prok2 Regulation of Trem1 1 0.04 0.66 0.13 39.88
109 INT240121 Hdc Regulation of Trem1 1 0.06 0.66 0.13 39.88
110 INT240120 Irg1 Regulation of Trem1 1 0.05 0.66 0.13 39.88
111 INT204091 Binding of HLA-G and KIR2DL1 1 0.15 0.86 0.32 39.76
112 INT330514 Vegfa Positive_regulation of VEGFA 1 0.18 0.5 0.18 39.20
113 INT149117 Binding of CD80 and CTLA4 31 0.52 12.7 7.73 39.00
114 INT186126 Binding of CD28 and CTLA4 9 0.52 4.13 3.12 39.00
115 INT186127 CTLA4 Negative_regulation of CD28 1 0.19 0.74 0.32 39.00
116 INT352890 Binding of PTGDS and ROS1 1 0.13 0.67 0.25 38.32
117 INT352894 Negative_regulation of Binding of ROS1 and GOPC 1 0.08 0.67 0.28 37.16
118 INT184194 Binding of HRAS and SPAM1 1 0.00 0.26 0.17 36.96
119 INT202037 Binding of CRP and URB1 1 0.01 1.26 0.68 36.84
120 INT197050 Binding of HLA-DOA and HLA-E 2 0.08 1.73 0.58 36.56
121 INT276968 Il6 Positive_regulation of Gene_expression of Stat3 2 0.20 1.54 0.21 36.48
122 INT334901 LDLR Positive_regulation of Crp 1 0.00 1.48 0.51 36.32
123 INT307074 Binding of Plg and Tbxas1 1 0.00 0.14 0 36.08
124 INT176473 IL10 Positive_regulation of Gene_expression of PECAM1 1 0.05 1.1 0.75 35.92
125 INT204090 Binding of KIR2DL2 and KIR2DS1 1 0.03 0.41 0.29 34.20
126 INT204089 Binding of KIR2DL3 and KIR2DS1 1 0.03 0.41 0.29 34.20
127 INT328743 TNF Positive_regulation of Mapk14 1 0.04 1.4 1.21 34.04
128 INT328742 Il1 Positive_regulation of Mapk14 1 0.01 1.4 1.2 34.04
129 INT141965 Binding of ADM and CALCRL 5 0.33 3.6 0.89 31.80
130 INT346151 Binding of ADM and GPER 1 0.01 0.99 0.41 31.80
131 INT182943 Binding of DR1 and NR1H4 3 0.03 0.14 0.06 31.40
132 INT252296 TNF Regulation of Gene_expression of Il1 2 0.03 1.28 0.49 26.28
133 INT252294 TNF Regulation of Gene_expression of Il6 2 0.16 1.28 0.49 26.28
134 INT307755 TNF Regulation of Gene_expression of IL8 1 0.02 0.5 0.14 26.28
135 INT307769 TNF Regulation of Gene_expression of Csf2 1 0.03 0.5 0.14 26.28
136 INT307771 TNF Negative_regulation of Gene_expression of Csf2 1 0.03 0.5 0.14 26.28
137 INT188519 Il1a Positive_regulation of Ptgis 1 0.03 0.08 0.08 25.72
138 INT54570 Positive_regulation of NFKB1 Positive_regulation of Gene_expression of IL8 1 0.24 0.77 0.35 25.00
139 INT224455 Pdgfa Regulation of VEGFA 1 0.07 0.22 0.11 22.96
140 INT173599 Binding of MMP1 and Mmp1a 1 0.06 0.5 0.15 18.12
141 INT323056 LDLR Regulation of HSD11B1 1 0.01 1.2 0.05 14.76
142 INT301287 Positive_regulation of Clec5a Positive_regulation of Gene_expression of Il6 1 0.14 0.58 0.29 11.64
143 INT300547 Il6 Positive_regulation of Il21 1 0.02 0.78 0.39 10.16
144 INT192291 OR5A1 Positive_regulation of Gene_expression of IGF1 1 0.02 0.93 0.57 9.80
145 INT346217 Braf Positive_regulation of Phosphorylation of Map2k1 1 0.22 3.23 1.72 9.68
146 INT316737 Il1 Positive_regulation of Mmp1a 1 0.01 0.64 0.54 9.20
147 INT209922 IL1B Positive_regulation of Gene_expression of NOS1 1 0.06 0.41 0.12 9.00
148 INT316738 Il1 Positive_regulation of Mmp3 1 0.02 0.63 0.54 8.92
149 INT316736 Il1 Positive_regulation of Timp1 1 0.04 0.63 0.54 8.52
150 INT176477 Binding of CXCR3 and CXCL10 14 0.25 10.61 5.87 5.00
151 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 0.59 9.37 4.48 5.00
152 INT182194 Binding of IL8 and CXCR2 10 0.56 7.14 4.16 5.00
153 INT152035 Binding of HLA-A and MRAP 2 0.31 6.95 3.4 5.00
154 INT194647 Binding of CD28 and CD80 15 0.40 4.9 3.22 5.00
155 INT208572 Binding of IL8 and CXCR1 6 0.33 5.2 3.08 5.00
156 INT130721 Binding of IL1B and IL1RN 6 0.05 5.29 2.85 5.00
157 INT175329 Binding of ICAM1 and ITGAL 14 0.18 10.06 2.81 5.00
158 INT186128 Binding of CD2 and CD58 8 0.10 7.59 2.76 5.00
159 INT122163 Binding of TNF and TNFRSF1B 6 0.44 6.06 2.41 5.00
160 INT115367 Binding of IL6 and IL6R 12 0.07 8.16 2.36 5.00
161 INT194646 Binding of CD28 and CD86 7 0.40 2.69 2.21 5.00
162 INT209924 IL1B Negative_regulation of PPARA 1 0.20 4.38 2.17 5.00
163 INT184262 Binding of AGER and HMGB1 1 0.34 4.49 2.17 5.00
164 INT239037 Binding of Cd28 and Cd86 9 0.16 3.69 2.14 5.00
165 INT148704 Binding of TNF and TNFRSF1A 5 0.44 3.3 2.09 5.00
166 INT196586 Negative_regulation of Mapk14 Negative_regulation of TNF 2 0.04 2.02 2.08 5.00
167 INT120723 Positive_regulation of Trpv1 Positive_regulation of Localization of Calca 3 0.51 0.48 1.92 5.00
168 INT102130 Il6 Positive_regulation of Gene_expression of Crp 4 0.05 7.39 1.91 5.00
169 INT183781 Binding of IL6 and INS 6 0.22 8.97 1.87 5.00
170 INT201940 Binding of IL8 and CXCL10 2 0.28 2.46 1.86 5.00
171 INT224432 TNF Positive_regulation of Gene_expression of VEGFA 1 0.13 5.83 1.8 5.00
172 INT89379 TNF Positive_regulation of Gene_expression of IL6 5 0.50 4.37 1.69 5.00
173 INT172047 Binding of HLA-A and LRRC23 1 0.22 3.32 1.64 5.00
174 INT254205 Binding of Myd88 and Tlr4 12 0.19 3.17 1.54 5.00
175 INT151849 IL10 Negative_regulation of Gene_expression of IL8 4 0.14 3.26 1.54 5.00
176 INT91456 IL1B Positive_regulation of Gene_expression of CPOX 6 0.17 3.36 1.53 5.00
177 INT285569 TNF Negative_regulation of Gene_expression of Il6 1 0.03 2.83 1.46 5.00
178 INT236365 Binding of CD40LG and IL6 3 0.20 4.16 1.42 5.00
179 INT121703 IL1B Positive_regulation of Gene_expression of MMP1 3 0.49 1.14 1.27 5.00
180 INT202042 CAMK2N2 Negative_regulation of MMP9 1 0.01 0.73 1.25 5.00
181 INT202041 CAMK2N2 Negative_regulation of PPP1R11 1 0.00 0.74 1.25 5.00
182 INT202039 CAMK2N2 Negative_regulation of MMP1 1 0.00 0.73 1.24 5.00
183 INT202036 CAMK2N2 Negative_regulation of MMP3 1 0.00 0.73 1.24 5.00
184 INT202040 CAMK2N2 Negative_regulation of MMP7 1 0.00 0.73 1.24 5.00
185 INT311914 Il1 Negative_regulation of Gene_expression of Col2a1 1 0.01 1.94 1.23 5.00
186 INT197092 TNF Regulation of VEGFA 4 0.21 2.78 1.22 5.00
187 INT209926 IL1B Regulation of PPARA 1 0.21 2.45 1.2 5.00
188 INT55162 Binding of NFKB1 and RELA 10 0.30 2.82 1.18 5.00
189 INT202620 Binding of Ppara and Rxra 15 0.09 2.63 1.11 5.00
190 INT230019 Binding of HLA-B and ERAL1 1 0.00 2.23 1.1 5.00
191 INT71176 Binding of ICAM1 and ITGB2 4 0.21 4.93 1.07 5.00
192 INT186125 Negative_regulation of Binding of CD2 and CD58 3 0.12 3.04 1.06 5.00
193 INT176474 Binding of CXCR3 and CXCL9 3 0.22 1.9 1.05 5.00
194 INT266742 GOPC Regulation of Positive_regulation of ACR 1 0.02 0.36 1.05 5.00
195 INT185373 IRF6 Positive_regulation of Gene_expression of TLR2 1 0.08 2.96 1.04 5.00
196 INT271875 IL1RN Negative_regulation of Binding of IL1B 1 0.01 1.3 1.01 5.00
197 INT178663 Binding of CXCR3 and TH1L 2 0.04 2.24 1.01 5.00
198 INT206074 Binding of IL6 and IL6ST 7 0.32 3.79 1.01 5.00
199 INT209923 IL17A Negative_regulation of PPARA 1 0.14 2.46 0.99 5.00
200 INT103796 IL1B Positive_regulation of Gene_expression of SELE 2 0.08 1 0.98 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Arthropathy. They are ordered first by their pain relevance and then by number of times they were reported in Arthropathy. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT188844 Gene_expression of AES 44 0.58 33.94 5.85 100.00
2 INT200443 Positive_regulation of AES 27 0.60 22.46 3.22 100.00
3 INT178592 Binding of ACP1 1 0.14 1.93 0.25 100.00
4 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 100.00
5 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 100.00
6 INT140338 Negative_regulation of Gene_expression of Il17a 34 0.46 23.82 9.87 100.00
7 INT92234 Regulation of CXCL10 15 0.42 8.37 5.09 100.00
8 INT92236 Regulation of Gene_expression of CXCL10 6 0.42 7.12 4.92 100.00
9 INT201955 Regulation of DPP4 18 0.45 11.91 1.18 100.00
10 INT200442 Positive_regulation of Gene_expression of AES 5 0.42 5.12 0.48 99.98
11 INT200441 Negative_regulation of Gene_expression of AES 1 0.36 1.56 0 99.98
12 INT27710 Binding of B2m 5 0.36 3.54 0.53 99.98
13 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 99.96
14 INT220251 Regulation of DPEP1 1 0.12 0.33 0.15 99.96
15 INT182318 Regulation of Birc5 25 0.60 23.58 2.29 99.92
16 INT637 Positive_regulation of MRAP 23 0.67 21.13 9.97 99.92
17 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58 99.92
18 INT6489 Positive_regulation of Gene_expression of Tnf 140 0.70 92.31 67.85 99.92
19 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 99.90
20 INT764 Gene_expression of OLAH 25 0.67 25.58 8.07 99.90
21 INT18954 Negative_regulation of OLAH 9 0.09 8.31 3.67 99.90
22 INT5009 Positive_regulation of Negative_regulation of Mmp13 1 0.06 0.1 0.42 99.90
23 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 99.88
24 INT58477 Gene_expression of Chdh 33 0.74 39.48 19.78 99.88
25 INT94465 Positive_regulation of Gene_expression of Hand1 43 0.38 29.76 10.88 99.88
26 INT184049 Positive_regulation of Gene_expression of Ighg2b 2 0.40 1.54 0.53 99.88
27 INT166203 Positive_regulation of Cia1 62 0.43 75.94 31.37 99.84
28 INT182031 Gene_expression of Cia1 38 0.24 46.37 19.64 99.84
29 INT15687 Regulation of ESR1 91 0.60 40.42 7.95 99.84
30 INT187089 Positive_regulation of Gene_expression of Cia1 9 0.14 10 4.11 99.84
31 INT219987 Positive_regulation of Positive_regulation of Cia1 3 0.05 4.41 1.81 99.84
32 INT5973 Regulation of IL1B 109 0.62 66.6 39.88 99.80
33 INT69866 Positive_regulation of Ptgds 26 0.70 16.25 8.33 99.74
34 INT13542 Negative_regulation of Localization of LTC4S 1 0.27 1.02 0.39 99.72
35 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53 99.68
36 INT184006 Gene_expression of Ighg2b 21 0.71 7.97 1.86 99.68
37 INT221448 Gene_expression of CREG1 8 0.05 27.44 10.87 99.64
38 INT116883 Gene_expression of SSX1 3 0.58 5.83 0.98 99.64
39 INT250927 Positive_regulation of Gene_expression of CREG1 1 0.03 2.39 0.8 99.64
40 INT118381 Gene_expression of Il17a 405 0.76 306.97 112.06 99.62
41 INT182311 Positive_regulation of Birc5 26 0.67 25.32 4.08 99.60
42 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 99.60
43 INT86291 Negative_regulation of Mmp2 33 0.57 20.38 10.76 99.60
44 INT6850 Gene_expression of SPANXB1 34 0.46 15.91 16.38 99.60
45 INT85776 Binding of Akp1 5 0.30 4.64 3.77 99.60
46 INT67822 Binding of SERPINH1 17 0.36 19.05 7.24 99.56
47 INT6852 Localization of TNF 883 0.81 705.95 270.84 99.54
48 INT7082 Gene_expression of CRH 180 0.78 64.66 31.74 99.52
49 INT6486 Positive_regulation of Tnf 168 0.70 123.47 66.05 99.52
50 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 99.46
51 INT220219 Binding of HUNK 1 0.26 12.47 3.78 99.44
52 INT1121 Protein_catabolism of C3 1 0.96 1.8 0.34 99.42
53 INT4807 Localization of LTC4S 23 0.58 6.89 7.59 99.32
54 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 99.32
55 INT39153 Positive_regulation of PTGS2 182 0.70 96.16 60.6 99.32
56 INT6848 Gene_expression of BDKRB2 40 0.75 17.19 20.04 99.32
57 INT143230 Gene_expression of CRYGD 61 0.65 52.11 15.93 99.16
58 INT60415 Regulation of NPEPPS 13 0.27 5.81 3.78 99.16
59 INT120688 Gene_expression of Atp6v0a2 7 0.10 7.5 4.4 99.16
60 INT68975 Gene_expression of Mmp9 111 0.78 79.57 38.55 99.12
61 INT68976 Positive_regulation of Gene_expression of Mmp9 34 0.42 28.21 11.28 99.12
62 INT28872 Positive_regulation of CSRP1 49 0.70 47.23 11.7 99.12
63 INT44637 Positive_regulation of Slc9a3r2 18 0.55 7.27 1.72 99.06
64 INT14560 Regulation of Igf1 41 0.59 19.59 6.3 99.00
65 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 98.96
66 INT173587 Protein_catabolism of COL5A2 59 0.32 32.73 8.96 98.96
67 INT1284 Negative_regulation of Mmp13 20 0.57 36.21 14.91 98.94
68 INT220216 Gene_expression of HUNK 1 0.41 14.77 4.24 98.92
69 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 98.92
70 INT220215 Positive_regulation of HUNK 1 0.28 1.11 0.29 98.92
71 INT129883 Gene_expression of Dkk1 56 0.77 45.42 12.52 98.88
72 INT111156 Negative_regulation of Dkk1 21 0.58 20.08 4.27 98.88
73 INT13541 Positive_regulation of Localization of LTC4S 3 0.51 1.01 0.75 98.88
74 INT344978 Negative_regulation of Gene_expression of Dkk1 1 0.58 4.38 1.59 98.88
75 INT2920 Regulation of F8 7 0.45 2.9 0.79 98.84
76 INT65472 Binding of HLA-G 9 0.36 6.06 2.6 98.84
77 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 98.76
78 INT184281 Binding of AGER 25 0.37 23.06 7.32 98.76
79 INT28952 Negative_regulation of Gene_expression of IGF1 75 0.58 41.11 12.32 98.76
80 INT27918 Positive_regulation of Klk1c7 6 0.36 2.89 2.84 98.76
81 INT14714 Negative_regulation of NPY 10 0.58 4.41 4.52 98.74
82 INT116465 Gene_expression of Birc5 241 0.78 192.31 15.32 98.72
83 INT129584 Positive_regulation of Stat3 97 0.68 87.07 14.86 98.68
84 INT158630 Positive_regulation of Positive_regulation of Stat3 16 0.49 14.75 3.08 98.68
85 INT23171 Negative_regulation of NLRP3 7 0.37 4.15 1.53 98.66
86 INT139830 Gene_expression of AGER 47 0.75 41.71 16.53 98.64
87 INT302808 Positive_regulation of Gene_expression of Il7 8 0.15 6.59 3.06 98.64
88 INT651 Positive_regulation of PTGS1 93 0.69 37.27 29.18 98.64
89 INT49751 Negative_regulation of Positive_regulation of PTGS1 12 0.45 4.73 7.23 98.64
90 INT302801 Positive_regulation of Positive_regulation of Il7 1 0.10 0.96 0.46 98.64
91 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 98.62
92 INT13353 Positive_regulation of Tnf 332 0.70 248.75 148.1 98.60
93 INT300537 Positive_regulation of Regulation of Il17a 1 0.39 1.74 0.29 98.58
94 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 98.56
95 INT141015 Regulation of Il18 14 0.59 6.3 3.73 98.56
96 INT195616 Binding of ROM1 4 0.23 1.61 0.9 98.56
97 INT55135 Positive_regulation of Gene_expression of PTGS2 137 0.70 80.32 38.46 98.52
98 INT37896 Positive_regulation of Gene_expression of PTGS1 37 0.67 17.28 9.27 98.52
99 INT20205 Binding of IgG 108 0.46 66.68 8.57 98.48
100 INT14448 Localization of COL5A2 34 0.67 17.35 2.85 98.44
101 INT192295 Protein_catabolism of MMP7 10 0.86 2.68 1.86 98.40
102 INT32464 Regulation of Mmp13 12 0.44 6.46 3.61 98.40
103 INT192302 Negative_regulation of Protein_catabolism of MMP7 2 0.01 0.21 0.26 98.40
104 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 98.36
105 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 98.36
106 INT62663 Negative_regulation of ABCA12 1 0.41 0.88 0.7 98.36
107 INT121241 Positive_regulation of P2rx7 65 0.69 40.94 13.59 98.36
108 INT531 Gene_expression of GH1 376 0.75 193.45 46.24 98.36
109 INT148 Positive_regulation of Gnrhr 182 0.70 47.44 79.64 98.32
110 INT170295 Positive_regulation of Ido1 40 0.67 28.89 7.61 98.32
111 INT129882 Positive_regulation of Gene_expression of Dkk1 4 0.69 4.62 0.72 98.32
112 INT29496 Gene_expression of MMP3 136 0.75 49.49 41.78 98.24
113 INT43727 Negative_regulation of Gene_expression of MMP3 16 0.40 4.81 7.18 98.24
114 INT115947 Regulation of Il17a 17 0.37 14.26 5.97 98.22
115 INT107541 Positive_regulation of MSD 7 0.43 5.41 1.45 98.20
116 INT4137 Positive_regulation of C3 73 0.69 48.57 12.63 98.20
117 INT846 Positive_regulation of B2M 42 0.70 29.78 8.06 98.16
118 INT37430 Gene_expression of Gpi1 61 0.63 54.63 13.87 98.16
119 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 98.16
120 INT26500 Gene_expression of MMP2 201 0.78 110.57 46.9 98.16
121 INT174801 Positive_regulation of Il7 5 0.15 4.76 2.31 98.16
122 INT111153 Positive_regulation of Dkk1 13 0.68 10.56 2.58 98.04
123 INT19330 Binding of HLA-A 99 0.48 76.26 22.85 98.04
124 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 98.00
125 INT11938 Positive_regulation of Localization of Il6 61 0.70 35.72 18.25 97.96
126 INT14737 Gene_expression of FN1 117 0.78 78.74 18.99 97.88
127 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 97.86
128 INT59165 Binding of fc 67 0.36 37.51 8.68 97.84
129 INT59384 Gene_expression of Il7 23 0.75 11.42 5.87 97.80
130 INT5284 Regulation of HLA-B 25 0.59 12.91 7.74 97.78
131 INT83886 Negative_regulation of HMOX2 27 0.43 11.69 10.78 97.68
132 INT13543 Positive_regulation of LTC4S 5 0.58 2.26 0.88 97.64
133 INT22003 Negative_regulation of Cpe 25 0.58 6.23 12.94 97.62
134 INT10606 Localization of Ltc4s 16 0.75 10.14 5.05 97.60
135 INT11937 Localization of Il6 228 0.81 139.83 64.39 97.60
136 INT135234 Regulation of ETFDH 13 0.29 10.8 3.4 97.60
137 INT204112 Gene_expression of GEM 43 0.75 38.74 11.23 97.56
138 INT8801 Gene_expression of Csf3 71 0.74 45.6 10.83 97.56
139 INT63977 Positive_regulation of Sele 28 0.68 18.49 4.17 97.48
140 INT170323 Regulation of Gene_expression of Ido1 11 0.60 8.74 2.33 97.44
141 INT106444 Binding of PHB2 4 0.48 13.74 4.07 97.40
142 INT106446 Positive_regulation of PHB2 3 0.66 4.38 1.62 97.40
143 INT21782 Negative_regulation of B2M 11 0.46 5.49 1.92 97.32
144 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 97.24
145 INT149371 Positive_regulation of Hivep3 2 0.40 1.58 0.81 97.24
146 INT1873 Gene_expression of MRAP 51 0.76 31.75 13.92 97.20
147 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 97.18
148 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 97.12
149 INT81627 Gene_expression of Fas 120 0.78 115.51 15.36 97.12
150 INT22562 Localization of Arsb 1 0.60 0.73 0.14 97.12
151 INT17582 Negative_regulation of Localization of ELANE 17 0.53 6.11 4.89 97.04
152 INT5905 Negative_regulation of ELANE 113 0.59 47.43 22.09 97.04
153 INT310681 Negative_regulation of ARSB 1 0.56 6.95 0.29 97.04
154 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47 97.00
155 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 97.00
156 INT39565 Gene_expression of Ptger2 424 0.75 229.28 72.68 97.00
157 INT39564 Negative_regulation of Gene_expression of Ptger2 50 0.42 30.9 12.97 97.00
158 INT22075 Positive_regulation of Gene_expression of IFNA2 7 0.64 4.7 1.45 96.98
159 INT11346 Binding of Mtx1 39 0.41 24.88 21.21 96.92
160 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 96.88
161 INT636 Binding of MRAP 54 0.48 40.36 18.77 96.80
162 INT151736 Binding of Hand1 15 0.26 9.77 4.04 96.80
163 INT37679 Positive_regulation of HLA-DRB4 12 0.34 11.93 1.16 96.72
164 INT2609 Localization of ELANE 111 0.81 50.22 26.63 96.68
165 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 96.64
166 INT31759 Negative_regulation of Gene_expression of Egf 6 0.53 5.33 0.77 96.64
167 INT24328 Gene_expression of Egf 97 0.75 59.65 9.42 96.64
168 INT141642 Positive_regulation of Ctsa 5 0.49 2.87 1.27 96.60
169 INT8903 Gene_expression of IFNA2 58 0.71 38.23 8.68 96.56
170 INT144086 Positive_regulation of Prok2 12 0.69 9.54 6.06 96.52
171 INT140555 Positive_regulation of Localization of ROS1 29 0.55 23.82 3.14 96.52
172 INT51055 Positive_regulation of TIMP1 103 0.69 50.07 19.86 96.48
173 INT178108 Positive_regulation of MMP7 11 0.56 7.31 2.85 96.48
174 INT55689 Positive_regulation of Transcription of TIMP1 3 0.46 1.02 0.67 96.48
175 INT118196 Gene_expression of ROM1 18 0.66 4.81 1.19 96.40
176 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 96.40
177 INT59466 Gene_expression of ISYNA1 204 0.77 112.57 35.48 96.36
178 INT73594 Positive_regulation of Gene_expression of ISYNA1 61 0.55 31.35 13.45 96.36
179 INT69396 Gene_expression of H2-K1 72 0.65 38.16 4.56 96.36
180 INT69397 Regulation of Gene_expression of H2-K1 9 0.23 6.32 0.91 96.36
181 INT68683 Regulation of Gene_expression of VEGFA 143 0.62 104.19 20.14 96.32
182 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 96.24
183 INT110809 Gene_expression of Mmp1 20 0.75 18 14.49 96.24
184 INT103327 Gene_expression of F8 45 0.71 32.5 2.12 96.24
185 INT2919 Negative_regulation of F8 47 0.59 23.48 5.1 96.24
186 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71 96.24
187 INT673 Positive_regulation of B2m 24 0.68 24.24 4.82 96.24
188 INT48232 Gene_expression of MMP1 245 0.78 96.31 57.72 96.20
189 INT129956 Gene_expression of MMP13 145 0.72 60.48 26.98 96.20
190 INT129962 Positive_regulation of Gene_expression of MMP13 41 0.65 20.74 8.54 96.20
191 INT92823 Positive_regulation of Gene_expression of MMP1 65 0.68 25.69 14.31 96.20
192 INT91434 Gene_expression of RPS6KB3 1 0.75 3.06 2.03 96.16
193 INT112003 Localization of ROS1 94 0.73 66.32 12.16 96.12
194 INT62336 Positive_regulation of Hdc 38 0.70 14.45 5.51 96.08
195 INT4727 Regulation of TAC1 60 0.47 6.74 32.83 96.00
196 INT149394 Positive_regulation of Mul1 4 0.12 1.89 0.53 96.00
197 INT31757 Negative_regulation of Egf 18 0.41 9.7 2.94 95.96
198 INT194561 Protein_catabolism of Abpd 1 0.12 2.19 0.89 95.92
199 INT194559 Positive_regulation of Protein_catabolism of Abpd 1 0.06 0.46 0.15 95.92
200 INT81629 Positive_regulation of Fas 58 0.70 59.63 12.94 95.88
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