D:Asphyxia

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Disease Term
Synonyms Asphyxias, Suffocation, Suffocations
Documents 529
Hot Single Events 87
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Asphyxia. They are ordered first by their relevance to Asphyxia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT238472 Binding of AVP and POR 1 0.02 0.85 0.09 86.36
2 INT131304 Binding of Serping1 and Sele 1 0.01 1.07 0.15 63.04
3 INT349344 Bdnf Negative_regulation of Casp3 1 0.13 0.96 0.22 62.24
4 INT242324 Lep Regulation of Gene_expression of Ucp1 1 0.58 1.47 0.09 41.52
5 INT235486 S100B Positive_regulation of Binding of CA2 1 0.13 0.08 0 38.64
6 INT260894 CRH Regulation of Localization of MMP3 1 0.21 0.36 0.85 19.36
7 INT272157 Gh1 Negative_regulation of Bcl2 1 0.23 1.2 0.26 6.80
8 INT272158 Gh1 Regulation of Bcl2 1 0.15 1.2 0.26 6.80
9 INT272161 Gh1 Negative_regulation of Gh1 Regulation of Bcl2 1 0.24 1.2 0.26 6.80
10 INT215096 Binding of Hmgb1 and Tlr2 9 0.38 11.61 1.61 5.00
11 INT260897 CRH Positive_regulation of Localization of IL8 1 0.24 0.09 1.51 5.00
12 INT308495 Pcsk5 Regulation of CFI 1 0.01 0.22 0.85 5.00
13 INT260895 CRH Regulation of MMP1 1 0.11 0.31 0.74 5.00
14 INT231533 IL4 Positive_regulation of LRP5 1 0.00 0.87 0.67 5.00
15 INT231534 Binding of JAK1 and SOAT1 1 0.01 0.6 0.64 5.00
16 INT302469 F2 Positive_regulation of Gene_expression of MMP9 1 0.01 1.82 0.62 5.00
17 INT354367 Binding of FGFR1 and Tlr4 1 0.01 1.23 0.53 5.00
18 INT288545 Gsk3b Negative_regulation of gr 1 0.25 0.38 0.38 5.00
19 INT231535 Binding of JAK2 and SOAT1 1 0.01 0.3 0.35 5.00
20 INT302466 Positive_regulation of F2 Positive_regulation of Gene_expression of MMP9 1 0.01 1.1 0.35 5.00
21 INT260893 CRH Positive_regulation of Gene_expression of IL8 1 0.28 0.05 0.31 5.00
22 INT260896 CRH Positive_regulation of Localization of MMP9 1 0.15 0.15 0.3 5.00
23 INT302467 TIMP1 Positive_regulation of Negative_regulation of COL5A2 1 0.00 1.1 0.29 5.00
24 INT354368 FGFR1 Positive_regulation of Tlr4 1 0.01 0.16 0.29 5.00
25 INT302468 INCENP Positive_regulation of Gene_expression of MMP9 1 0.01 0.72 0.26 5.00
26 INT258289 Hmgb1 Positive_regulation of Tlr2 4 0.48 3.61 0.19 5.00
27 INT326464 KNG1 Positive_regulation of SERPING1 1 0.19 1.53 0.18 5.00
28 INT349345 Bdnf Negative_regulation of Positive_regulation of Casp3 1 0.13 1.02 0.12 5.00
29 INT265919 Binding of PLEK and Adp 1 0.01 0.38 0.11 5.00
30 INT236266 Binding of Pgk1 and Ppia 1 0.13 0.71 0.11 5.00
31 INT337072 Binding of Fmr1 and Gusb 1 0.19 1.55 0.08 5.00
32 INT258290 Hmgb1 Regulation of Positive_regulation of Tlr2 1 0.46 1.04 0.05 5.00
33 INT283226 Binding of ACE and CC2D1A 1 0.11 2.37 0.04 5.00
34 INT302493 Binding of AGRP and IMPACT 1 0.25 0.53 0 5.00
35 INT353910 Binding of CRP and UROD 1 0.06 0.34 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Asphyxia. They are ordered first by their pain relevance and then by number of times they were reported in Asphyxia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT8056 Regulation of Positive_regulation of Penk 34 0.59 4.71 17.66 100.00
2 INT49706 Positive_regulation of TNNT2 22 0.69 12.65 1.56 99.98
3 INT728 Positive_regulation of Penk 1068 0.70 186.9 636.87 99.84
4 INT52486 Negative_regulation of PTPRU 3 0.35 1.16 0.96 99.72
5 INT138844 Positive_regulation of CC2D1A 25 0.41 41.36 1.92 99.72
6 INT937 Positive_regulation of Oxt 195 0.70 37.82 49.3 99.58
7 INT352343 Negative_regulation of Positive_regulation of PTPRU 1 0.02 0.4 0 99.56
8 INT171145 Positive_regulation of Fig4 274 0.59 93.55 69.81 99.52
9 INT41639 Positive_regulation of A2m 7 0.46 4.52 1.74 99.12
10 INT16814 Negative_regulation of COX5A 74 0.57 33.72 28.63 99.00
11 INT1395 Negative_regulation of Penk 537 0.59 87.33 389.81 98.92
12 INT684 Binding of AVP 38 0.48 13.9 8.85 98.88
13 INT68973 Positive_regulation of Mmp9 89 0.52 58.56 30.04 98.84
14 INT14562 Negative_regulation of Igfbp1 7 0.26 4.32 1.5 98.74
15 INT34864 Binding of Cp 23 0.47 5.17 1.78 98.72
16 INT177581 Regulation of Fig4 113 0.41 39.26 27.75 98.62
17 INT52482 Positive_regulation of PTPRU 5 0.42 0.39 2.27 98.48
18 INT34599 Binding of TST 7 0.32 3.88 0.71 98.32
19 INT74628 Positive_regulation of Mmp7 8 0.25 4.19 2.27 98.20
20 INT3880 Negative_regulation of Serping1 54 0.58 37.19 4.75 98.12
21 INT41942 Gene_expression of A2m 9 0.36 9.98 3.96 98.08
22 INT3822 Negative_regulation of Negative_regulation of C1s 3 0.20 1.25 0.69 97.48
23 INT3117 Regulation of Oxt 103 0.61 17.93 32.28 97.36
24 INT97331 Positive_regulation of Timp1 20 0.45 13.32 8.57 97.28
25 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 97.24
26 INT3821 Negative_regulation of C1s 13 0.42 7.89 2.08 97.08
27 INT30531 Gene_expression of C2 15 0.66 5.5 1.99 96.76
28 INT569 Negative_regulation of C4a 13 0.42 9.48 2.85 96.60
29 INT2732 Gene_expression of VIP 74 0.78 24.57 33.72 96.52
30 INT74260 Positive_regulation of Serping1 5 0.64 6.05 0.8 95.80
31 INT98739 Gene_expression of Fbrs 6 0.52 4.77 0.4 95.64
32 INT19822 Gene_expression of Artles 2 0.01 0.27 0.35 95.20
33 INT29635 Localization of Eno2 9 0.76 6.05 1.35 94.68
34 INT3410 Positive_regulation of Artles 9 0.04 2.57 2.5 94.04
35 INT115386 Gene_expression of Ppara 779 0.77 549.99 128.36 93.52
36 INT122039 Positive_regulation of Gene_expression of Ppara 144 0.68 113.55 28.55 93.52
37 INT927 Gene_expression of Oxt 184 0.78 44.71 35.79 93.28
38 INT4740 Gene_expression of Th 298 0.78 61.27 154.03 93.20
39 INT26719 Negative_regulation of Gene_expression of Th 38 0.58 11.87 22.78 93.20
40 INT103300 Negative_regulation of Gene_expression of CRTAC1 3 0.44 2.87 0.7 93.20
41 INT20055 Gene_expression of CRTAC1 19 0.58 15.49 4.73 93.20
42 INT81530 Gene_expression of Nfkb1 93 0.78 48.58 32.58 92.72
43 INT91374 Negative_regulation of Gene_expression of Nfkb1 12 0.58 5.06 1.75 92.72
44 INT341638 Binding of Arid1a 2 0.09 4.25 0.04 92.40
45 INT73239 Negative_regulation of Gene_expression of Mbp 6 0.46 5.65 1.96 91.24
46 INT45413 Transcription of Serping1 1 0.68 0.9 0 91.20
47 INT138843 Binding of CC2D1A 19 0.33 33.06 1.25 91.08
48 INT17741 Gene_expression of MBP 67 0.78 23.67 9.65 90.44
49 INT236264 Positive_regulation of Transcription of Hspe1 1 0.19 0.64 0.12 90.32
50 INT236263 Transcription of Hspe1 1 0.26 0.64 0.12 90.32
51 INT2330 Regulation of CB 78 0.10 20.46 32.6 90.20
52 INT106307 Positive_regulation of UROD 27 0.49 16.63 2.19 90.04
53 INT14887 Gene_expression of Mbp 55 0.75 36.13 16.11 89.84
54 INT9750 Positive_regulation of Rara 39 0.66 12.44 15.83 89.60
55 INT16259 Positive_regulation of Bdnf 336 0.70 183.48 209.82 89.48
56 INT47683 Negative_regulation of Bdnf 92 0.59 47.53 43.55 89.48
57 INT4937 Negative_regulation of Oprd1 224 0.59 44.51 171.11 88.88
58 INT190394 Negative_regulation of Lefty1 2 0.09 0.52 0.38 88.32
59 INT22548 Positive_regulation of Casp3 483 0.70 258.78 213.07 88.08
60 INT96919 Positive_regulation of Snd1 3 0.41 0.94 0.53 87.88
61 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 87.68
62 INT45597 Negative_regulation of Epo 22 0.59 12.47 2.35 87.36
63 INT170646 Negative_regulation of Fig4 213 0.37 81.29 46.92 87.04
64 INT671 Positive_regulation of Cea 221 0.69 164.5 47.79 87.04
65 INT227437 Positive_regulation of CSR 1 0.30 1.81 0 87.04
66 INT145425 Positive_regulation of NLRP1 19 0.47 6.93 12.09 86.72
67 INT11699 Binding of HLA-E 85 0.47 52.51 13.41 86.36
68 INT12249 Binding of POR 5 0.35 2.76 0.35 86.36
69 INT796 Gene_expression of Penk 1902 0.78 275.47 1057.59 86.24
70 INT16618 Negative_regulation of SERPING1 81 0.59 86.28 7.17 84.84
71 INT93546 Regulation of UROD 4 0.32 2.9 0.37 84.84
72 INT236253 Positive_regulation of Dnajb6 1 0.02 0.51 0.12 84.56
73 INT310196 Localization of Serping1 2 0.39 2.64 0.04 84.48
74 INT17742 Localization of S100B 44 0.80 17.14 4.65 84.12
75 INT108761 Localization of Alms1 24 0.70 13.92 3.74 83.48
76 INT56310 Gene_expression of Baat 15 0.44 15.5 1.11 83.24
77 INT70970 Binding of COPD 144 0.42 180.34 18.29 83.12
78 INT66332 Gene_expression of Ucp1 40 0.75 40.09 2.48 83.08
79 INT14282 Regulation of INA 5 0.23 0.87 2.42 82.76
80 INT99270 Negative_regulation of Gene_expression of Pvalb 5 0.08 5.74 3.15 82.52
81 INT4585 Gene_expression of Serping1 19 0.46 12.4 2.35 82.04
82 INT15777 Gene_expression of Pvalb 66 0.78 25.97 26.13 81.68
83 INT224396 Negative_regulation of UROD 2 0.30 1.57 0.12 80.72
84 INT5194 Positive_regulation of Lpo 63 0.70 26.44 8.37 80.72
85 INT21720 Negative_regulation of Positive_regulation of Lpo 8 0.43 2.98 0.69 80.72
86 INT227349 Positive_regulation of Positive_regulation of Lpo 2 0.27 1.6 0.05 80.72
87 INT352342 Binding of APOBEC3C 1 0.01 0.28 0 80.56
88 INT106745 Localization of CRP 65 0.81 66.44 15.21 79.92
89 INT224398 Localization of UROD 3 0.49 1.71 0.25 79.92
90 INT76434 Negative_regulation of PRKG1 25 0.58 10.36 10.81 79.52
91 INT281803 Regulation of Ucp1 4 0.57 4.03 0.05 79.32
92 INT49302 Localization of TNNT2 6 0.78 3.1 0.34 77.36
93 INT146661 Positive_regulation of D230030E09Rik 1 0.40 0.92 0.73 76.76
94 INT28782 Negative_regulation of Slc43a3 13 0.35 5.02 5.01 76.72
95 INT56309 Positive_regulation of Baat 9 0.39 8.47 1.51 75.76
96 INT45722 Negative_regulation of CFHR1 6 0.56 1.43 0.78 75.00
97 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 72.96
98 INT4587 Negative_regulation of Serping1 32 0.47 19.11 5.92 72.88
99 INT23775 Regulation of S100B 24 0.62 16.75 2.57 72.48
100 INT57502 Positive_regulation of Gene_expression of CRH 30 0.70 23.37 5.7 72.24
101 INT200385 Negative_regulation of ADC 19 0.18 16.56 3.6 72.24
102 INT7082 Gene_expression of CRH 180 0.78 64.66 31.74 72.24
103 INT149138 Binding of PDX1 27 0.37 32.62 9.33 71.12
104 INT163133 Gene_expression of ZBP1 28 0.65 18.59 1.25 71.12
105 INT18893 Positive_regulation of CPP 81 0.69 38.03 34.33 70.72
106 INT319339 Localization of ZBP1 3 0.18 3.09 0.2 69.76
107 INT84546 Positive_regulation of Ppara 481 0.70 334.21 83.45 68.64
108 INT157932 Positive_regulation of ADHD1 46 0.48 52.18 6.13 68.08
109 INT157720 Localization of ADHD1 15 0.64 15.84 1.69 68.08
110 INT63975 Positive_regulation of Il10 175 0.68 134.13 54.69 67.52
111 INT244082 Protein_catabolism of Tg(CAG-EGFP)D4Nagy 4 0.23 1.48 0.29 67.24
112 INT64346 Positive_regulation of S100B 95 0.70 63.11 9.17 67.12
113 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 66.92
114 INT15921 Positive_regulation of Serpine1 85 0.68 81.24 13.4 66.20
115 INT151427 Gene_expression of ADC 31 0.55 21.86 3.81 64.80
116 INT246711 Negative_regulation of Gene_expression of ADC 5 0.06 4.12 0.53 64.80
117 INT20665 Gene_expression of ACE 87 0.78 51.71 14.19 64.48
118 INT83006 Gene_expression of AGTR1 59 0.75 54.46 7.27 64.48
119 INT97596 Localization of S100a8 94 0.78 90.69 40.41 64.24
120 INT11854 Gene_expression of Il1rl1 57 0.77 30.19 38.25 62.48
121 INT11855 Positive_regulation of Gene_expression of Il1rl1 19 0.69 12.22 14.57 62.48
122 INT142056 Binding of NLRP1 7 0.47 1.7 2.02 61.84
123 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 58.96
124 INT220335 Gene_expression of UROD 34 0.54 24.53 2.89 58.64
125 INT11340 Positive_regulation of SLC17A5 120 0.67 113.52 14.5 58.16
126 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 56.96
127 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 56.96
128 INT353911 Negative_regulation of Regulation of UROD 1 0.10 0.59 0.08 56.40
129 INT39153 Positive_regulation of PTGS2 182 0.70 96.16 60.6 53.08
130 INT242323 Localization of Ucp1 1 0.67 1.75 0.1 52.36
131 INT6163 Negative_regulation of INA 39 0.43 2.9 14.8 51.16
132 INT16969 Negative_regulation of CRS 28 0.37 14.77 3.35 50.72
133 INT50454 Regulation of Gene_expression of DNAH8 6 0.44 2.56 0.97 50.60
134 INT131301 Binding of Serping1 3 0.28 1.86 0.3 50.08
135 INT26462 Gene_expression of DNAH8 44 0.78 19.36 7.31 50.04
136 INT12029 Gene_expression of Car1 143 0.67 29.69 36.39 50.00
137 INT104441 Binding of NOVA2 72 0.42 16.41 10.51 50.00
138 INT32239 Gene_expression of Car3 38 0.67 6.86 9.76 50.00
139 INT12028 Regulation of Car1 28 0.43 9.01 7.84 50.00
140 INT20839 Regulation of Car3 12 0.45 4.13 5.97 50.00
141 INT17598 Positive_regulation of CFHR1 11 0.50 2.6 2.38 50.00
142 INT3810 Regulation of CFHR1 7 0.38 1.19 2.13 50.00
143 INT82968 Phosphorylation of Hltf 2 0.31 0.07 0.74 50.00
144 INT119270 Regulation of Fbrs 3 0.53 1.41 0.17 50.00
145 INT225200 Binding of Fbrs 1 0.05 0.43 0.08 50.00
146 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 47.44
147 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 47.44
148 INT44550 Positive_regulation of Gene_expression of AVP 38 0.70 22.27 8.62 47.16
149 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 47.08
150 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 46.08
151 INT3679 Gene_expression of AVP 171 0.78 72.9 35.23 45.72
152 INT51065 Transcription of S100B 3 0.60 0.83 0.17 45.64
153 INT235488 Negative_regulation of Transcription of S100B 1 0.37 0.09 0 45.64
154 INT235487 Regulation of Transcription of S100B 1 0.39 0.09 0 45.64
155 INT236260 Gene_expression of Actb 1 0.59 1.42 0.41 45.44
156 INT236258 Regulation of Gene_expression of Actb 1 0.34 1.09 0.35 45.44
157 INT68187 Gene_expression of TNNT2 21 0.67 10.22 1.64 44.96
158 INT163581 Localization of Lep 27 0.79 18.99 4.08 44.72
159 INT147792 Gene_expression of COPD 230 0.70 287.13 24.1 44.40
160 INT236254 Gene_expression of B2m 1 0.73 1.24 0.07 44.28
161 INT269281 Negative_regulation of PEA15 1 0.05 0.61 0 44.16
162 INT180298 Regulation of Positive_regulation of S100B 3 0.39 1.09 0.04 43.28
163 INT58918 Gene_expression of SDHB 5 0.75 2.93 1.27 42.64
164 INT112974 Gene_expression of Ucp1 12 0.78 7.72 2.45 41.52
165 INT47690 Regulation of Bdnf 118 0.62 53.02 64.5 40.88
166 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 39.32
167 INT6441 Positive_regulation of CRH 98 0.69 57.22 24.12 39.28
168 INT57368 Regulation of ADHD1 39 0.50 42.23 5.01 39.20
169 INT1539 Positive_regulation of MSMB 22 0.69 9.42 4.62 38.88
170 INT50669 Negative_regulation of Ptn 15 0.58 5.56 6.88 38.80
171 INT129967 Binding of Cnot4 3 0.03 2.61 0.75 38.32
172 INT5490 Binding of CA2 52 0.36 9.73 5.53 38.00
173 INT11325 Gene_expression of HLA-E 209 0.76 98.05 33.72 37.92
174 INT3535 Regulation of CA2 61 0.32 16.48 10.8 37.24
175 INT236255 Regulation of Actb 1 0.47 0.59 0.18 37.20
176 INT15376 Positive_regulation of Gene_expression of ERBB2 215 0.70 168.54 5.23 35.32
177 INT56047 Negative_regulation of Transcription of Bdnf 16 0.59 8.02 5.67 35.04
178 INT74682 Positive_regulation of Mmp2 72 0.69 40.46 21.73 34.16
179 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79 33.20
180 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81 32.00
181 INT74587 Gene_expression of MMP8 31 0.78 24.4 14.91 31.20
182 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 31.04
183 INT16261 Transcription of Bdnf 101 0.72 49.41 40.64 30.80
184 INT29496 Gene_expression of MMP3 136 0.75 49.49 41.78 30.64
185 INT48232 Gene_expression of MMP1 245 0.78 96.31 57.72 30.08
186 INT227022 Negative_regulation of Gene_expression of AHSA2 1 0.34 0.42 0 29.76
187 INT227024 Gene_expression of AHSA2 1 0.62 0.42 0 29.76
188 INT37835 Negative_regulation of CPP 61 0.51 31.34 18.57 28.96
189 INT106749 Negative_regulation of Negative_regulation of Casp3 6 0.34 5.12 1.48 28.80
190 INT27493 Negative_regulation of Casp3 114 0.56 56.89 44.63 27.92
191 INT242322 Positive_regulation of Hyou1 1 0.01 1.2 0.09 27.52
192 INT149999 Negative_regulation of Gene_expression of BAD 4 0.13 5.46 0.45 27.48
193 INT119830 Gene_expression of BAD 24 0.50 20.05 1.41 26.92
194 INT236247 Regulation of Gene_expression of Ppia 1 0.21 0.56 0.17 26.64
195 INT133112 Regulation of Baat 2 0.61 11.99 1.2 25.12
196 INT1982 Regulation of NARFL 119 0.49 116.2 14.35 25.00
197 INT3244 Negative_regulation of eCB 37 0.03 16.69 12.61 25.00
198 INT626 Localization of CALCA 289 0.81 125.39 221.15 24.56
199 INT11406 Positive_regulation of Localization of CALCA 49 0.70 20.64 42.8 24.56
200 INT94007 Binding of Pphn 4 0.31 0.63 0.31 23.20
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