D:Asthenia

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Disease Term
Synonyms Asthaenia, ASTHENIAS, Chronic Asthaenia Disease, CHRONIC ASTHAENIA SYNDROME, Chronic Asthenia Disease, CHRONIC ASTHENIA SYNDROME
Documents 735
Hot Single Events 79
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Asthenia. They are ordered first by their relevance to Asthenia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT278015 Gh Regulation of Ins1 1 0.10 1.47 0.27 80.44
2 INT278018 Gh Negative_regulation of Phosphorylation of Ins1 1 0.13 1.5 0.29 77.52
3 INT278012 Gh Positive_regulation of Gene_expression of Ins1 1 0.11 1.24 0.26 63.92
4 INT278016 Gh Positive_regulation of Localization of Ins1 1 0.16 1.22 0.26 61.44
5 INT224308 INSRR Regulation of VEGFA 1 0.00 1.42 0.16 60.28
6 INT297613 Negative_regulation of ZNF275 Positive_regulation of Gene_expression of TSC1 1 0.00 1.66 0 56.32
7 INT297614 ZNF275 Positive_regulation of Gene_expression of TSC1 1 0.00 1.56 0 52.72
8 INT267644 Binding of Das and RLS 1 0.06 1.04 0.35 47.08
9 INT105267 Negative_regulation of VEGFA Positive_regulation of KDR 1 0.16 0.22 0.05 41.20
10 INT105268 VEGFA Positive_regulation of KDR 2 0.18 0.22 0.05 41.20
11 INT258492 Binding of Ins1 and Cdipt 1 0.00 0.92 0 36.96
12 INT351007 Binding of IL2 and IL2RA 1 0.33 1.33 0.26 34.72
13 INT315856 FLT3 Positive_regulation of Gene_expression of PDGFA 1 0.01 1.15 0 34.16
14 INT173059 Binding of KDR and VEGFA 43 0.43 29.63 1.1 33.08
15 INT274387 Binding of POLA1 and IGSF9 1 0.01 0.58 0 30.60
16 INT213903 Binding of EGFR and ERBB2 10 0.37 5.03 0.04 27.12
17 INT109502 GBE1 Negative_regulation of HIVEP1 1 0.00 1.85 0 26.96
18 INT101339 ZAK Regulation of Gene_expression of AXL 1 0.01 0.32 0.12 25.00
19 INT198382 Binding of AR and SRD5A1 2 0.06 0.84 0.17 17.92
20 INT121651 Binding of CXCL12 and CXCR4 13 0.48 17.61 3.52 5.00
21 INT241750 Binding of CD4 and ITIH4 14 0.18 5.72 1.53 5.00
22 INT299311 Binding of RPTOR and RICTOR 1 0.38 0.21 1.4 5.00
23 INT299281 Binding of RPTOR and MAPKAP1 1 0.23 0.21 1.3 5.00
24 INT70226 Binding of TAC1 and B3GAT1 4 0.24 4.5 1.26 5.00
25 INT299299 VEGFA Positive_regulation of SRC 1 0.20 0.91 1.2 5.00
26 INT99577 Binding of KITLG and Kit 3 0.34 2.33 1.11 5.00
27 INT262367 Tcas1 Positive_regulation of Localization of Adh4 1 0.01 1.91 1.01 5.00
28 INT299282 PTPN3 Negative_regulation of Positive_regulation of RPTOR 1 0.07 0.48 0.67 5.00
29 INT339794 Sstr2 Positive_regulation of Gene_expression of Sstr5 1 0.08 0.25 0.64 5.00
30 INT45780 GNRH1 Positive_regulation of PLOD1 3 0.07 1.02 0.63 5.00
31 INT299286 VEGFA Positive_regulation of PI3 1 0.16 0.46 0.6 5.00
32 INT351076 IK Positive_regulation of Gene_expression of Ucp3 1 0.00 0.8 0.58 5.00
33 INT299263 PTPN3 Negative_regulation of VEGFA Positive_regulation of SRC 1 0.03 0.35 0.57 5.00
34 INT342181 Binding of Igfals and Ros1 1 0.01 0.76 0.41 5.00
35 INT299288 AKT1 Positive_regulation of RPTOR 1 0.34 0.05 0.36 5.00
36 INT353128 Negative_regulation of Binding of TAC1 and B3GAT1 1 0.29 1.95 0.33 5.00
37 INT299307 AKT1 Positive_regulation of Positive_regulation of AKT1S1 1 0.10 0 0.3 5.00
38 INT206704 Negative_regulation of Binding of KDR and VEGFA 4 0.39 5.18 0.3 5.00
39 INT299289 AKT1 Positive_regulation of Positive_regulation of TSC2 1 0.17 0 0.3 5.00
40 INT272997 Binding of CYP3A4 and IL33 1 0.03 0 0.25 5.00
41 INT272998 IL33 Negative_regulation of CYP2D6 1 0.04 0 0.25 5.00
42 INT241822 Binding of CD4 and HIVEP1 3 0.01 2.73 0.21 5.00
43 INT182634 Binding of CCR5 and MIP 2 0.39 1.29 0.2 5.00
44 INT316748 IL18 Positive_regulation of Regulation of Hand2 1 0.14 1.11 0.18 5.00
45 INT274386 Binding of CD4 and ERVW-1 1 0.05 3.07 0.18 5.00
46 INT249962 Binding of KIT and KITLG 6 0.19 3.69 0.17 5.00
47 INT278020 Binding of Gh and Sst 1 0.18 0.16 0.15 5.00
48 INT331628 Binding of HLA-DQA2 and Pain1 1 0.01 2.13 0.14 5.00
49 INT331627 Binding of HLA-DRB3 and Pain1 1 0.00 2.15 0.14 5.00
50 INT267799 Binding of RLS and ADHD1 1 0.00 4.84 0.14 5.00
51 INT299310 RPTOR Positive_regulation of AKT1 1 0.30 0 0.12 5.00
52 INT331612 ETV4 Positive_regulation of Gene_expression of TGFB1 1 0.00 1.32 0.12 5.00
53 INT315829 Binding of EGFR and TKT 1 0.03 1.14 0.12 5.00
54 INT241748 CCR5 Regulation of CD4 1 0.21 0.39 0.11 5.00
55 INT65676 Binding of CGA and PLOD1 3 0.23 1.68 0.1 5.00
56 INT277692 Binding of Atp9a and Tnfrsf10b 1 0.00 1.47 0.1 5.00
57 INT342288 Binding of CD4 and HFE 1 0.01 1.26 0.08 5.00
58 INT244640 AGK Negative_regulation of KIT 1 0.00 0.69 0.08 5.00
59 INT251777 Negative_regulation of TXK Positive_regulation of PDGFA 1 0.04 1 0.08 5.00
60 INT351011 Binding of HDAC9 and TSPYL2 1 0.04 0.63 0.08 5.00
61 INT244639 AGK Negative_regulation of PDGFRB 1 0.01 0.69 0.08 5.00
62 INT251773 TXK Positive_regulation of PDGFA 1 0.04 1 0.08 5.00
63 INT244638 AGK Negative_regulation of KDR 1 0.00 0.68 0.08 5.00
64 INT279286 Binding of TXK and VEGFA 3 0.05 2.35 0.07 5.00
65 INT331626 Edn1 Positive_regulation of Itk 1 0.00 0.57 0.07 5.00
66 INT251775 AGK Negative_regulation of INSRR 1 0.00 1.1 0.07 5.00
67 INT278059 XRCC1 Positive_regulation of Gene_expression of IL2 1 0.01 1.06 0.07 5.00
68 INT331629 Binding of TGFB1 and Positive_regulation of Gene_expression of Itk 1 0.00 0.84 0.07 5.00
69 INT299291 Negative_regulation of PTPN3 Positive_regulation of Phosphorylation of SRC 1 0.07 0.12 0.07 5.00
70 INT187671 CGA Negative_regulation of Gene_expression of GNRH1 1 0.01 0 0.06 5.00
71 INT251776 Negative_regulation of TXK Negative_regulation of ERBB4 1 0.04 1.07 0.06 5.00
72 INT251774 Negative_regulation of TXK Negative_regulation of EGFR 1 0.07 1.06 0.06 5.00
73 INT244641 PDGFA Regulation of MTOR 1 0.07 2.55 0.06 5.00
74 INT251778 Negative_regulation of TXK Positive_regulation of KDR 1 0.03 0.99 0.05 5.00
75 INT313886 RPS6KB1 Positive_regulation of Gene_expression of XRCC1 1 0.01 0.8 0.05 5.00
76 INT351010 ISG20 Positive_regulation of Transcription of IL2 1 0.31 0.46 0.05 5.00
77 INT313890 Akt1 Positive_regulation of Gene_expression of XRCC1 1 0.00 0.79 0.05 5.00
78 INT351009 IL2RG Positive_regulation of Transcription of IL2 1 0.27 0.44 0.05 5.00
79 INT351012 IL2RB Positive_regulation of Gene_expression of IL15 1 0.10 0.42 0.05 5.00
80 INT351008 IL2RB Positive_regulation of Gene_expression of IL2 1 0.18 0.42 0.05 5.00
81 INT198358 GH1 Regulation of Igf1 1 0.00 0.09 0.05 5.00
82 INT224310 EPAS1 Positive_regulation of CXCL12 1 0.02 0.63 0.05 5.00
83 INT299264 PTPN3 Negative_regulation of VEGFA Positive_regulation of PI3 1 0.03 0.12 0.05 5.00
84 INT299302 Negative_regulation of RPTOR Regulation of AKT1 1 0.30 0.1 0.05 5.00
85 INT299304 RPTOR Regulation of AKT1 1 0.19 0.1 0.05 5.00
86 INT251779 TXK Positive_regulation of KDR 1 0.03 0.99 0.05 5.00
87 INT279284 TXK Regulation of KDR 3 0.05 2.22 0.04 5.00
88 INT241751 Negative_regulation of Binding of CD4 and ITIH4 3 0.18 1.07 0.04 5.00
89 INT241752 ITIH4 Negative_regulation of Binding of CXCR4 1 0.08 0.71 0.04 5.00
90 INT241749 ITIH4 Negative_regulation of Binding of CCR5 1 0.16 0.71 0.04 5.00
91 INT187732 Binding of CYP19A1 and Cyp11a1 1 0.01 0.68 0.04 5.00
92 INT224304 KDR Positive_regulation of Binding of VEGFA 1 0.24 0.36 0.03 5.00
93 INT341847 ERBB2 Positive_regulation of Gene_expression of ESYT1 1 0.02 1.42 0.03 5.00
94 INT229098 Binding of TP53 and IER3 1 0.01 1.47 0.03 5.00
95 INT224309 Binding of VEGFA and NUDT6 1 0.05 0.39 0.03 5.00
96 INT187676 Binding of CYP19A1 and SHBG 1 0.01 0.63 0.03 5.00
97 INT224306 KDR Positive_regulation of VEGFA 1 0.24 0.36 0.03 5.00
98 INT274384 AGRP Negative_regulation of HIVEP1 1 0.00 0.77 0.03 5.00
99 INT192678 PTEN Regulation of Dync1h1 1 0.02 0.5 0.03 5.00
100 INT224305 Positive_regulation of Binding of KDR and VEGFA 2 0.45 0.36 0.03 5.00
101 INT260342 Binding of Esr1 and Rcc1 1 0.05 0.99 0 5.00
102 INT277693 Stat6 Positive_regulation of Positive_regulation of Casp3 1 0.01 1.01 0 5.00
103 INT187672 Binding of DBT and SCN5A 1 0.00 0.2 0 5.00
104 INT187677 Negative_regulation of FSHR Positive_regulation of DBT 1 0.03 0 0 5.00
105 INT299312 VEGFA Positive_regulation of QPCT 1 0.02 0 0 5.00
106 INT299303 SRC Regulation of Phosphorylation of VEGFA 1 0.12 0.05 0 5.00
107 INT278014 Ptprf Regulation of Localization of Gh 1 0.61 0.31 0 5.00
108 INT251780 RRAD Negative_regulation of MTOR 1 0.00 0.62 0 5.00
109 INT341315 Binding of RTN4R and HCC 1 0.02 0.74 0 5.00
110 INT277691 Cdkn1a Negative_regulation of Positive_regulation of Casp3 1 0.00 1.01 0 5.00
111 INT187675 DBT Positive_regulation of Gene_expression of LEP 1 0.04 0.27 0 5.00
112 INT283630 Cd36 Regulation of Positive_regulation of Ie 1 0.00 0 0 5.00
113 INT283633 Binding of Vcam1 and Ie 1 0.00 0.17 0 5.00
114 INT345505 E2f1 Positive_regulation of PMAIP1 1 0.18 0.62 0 5.00
115 INT299305 VEGFA Positive_regulation of Positive_regulation of SRC 1 0.22 0 0 5.00
116 INT350981 VHL Regulation of XRCC1 1 0.01 1.42 0 5.00
117 INT341316 Negative_regulation of Binding of RTN4R and HCC 1 0.02 0.79 0 5.00
118 INT345489 TP53 Positive_regulation of PMAIP1 1 0.05 0.6 0 5.00
119 INT278293 Binding of DBP and SHBG 2 0.02 1.34 0 5.00
120 INT299300 SRC Positive_regulation of Phosphorylation of AKT1 1 0.24 0 0 5.00
121 INT299309 VEGFA Positive_regulation of Positive_regulation of PI3 1 0.18 0 0 5.00
122 INT211883 Binding of RET and CDCP1 1 0.00 2.12 0 5.00
123 INT315868 Vhl Positive_regulation of Transcription of PDGFA 1 0.00 1.39 0 5.00
124 INT345485 Binding of MCL1 and BBC3 1 0.01 0.79 0 5.00
125 INT299292 RPTOR Negative_regulation of PI3 1 0.25 0 0 5.00
126 INT299296 SRC Regulation of RPTOR 1 0.32 0 0 5.00
127 INT331611 NKX2-1 Regulation of Transcription of SFTPB 1 0.01 0.49 0 5.00
128 INT264683 Binding of VAPB and ALS2 1 0.29 1.1 0 5.00
129 INT299306 Binding of QPCT and RICTOR 1 0.02 0 0 5.00
130 INT351013 PROK1 Regulation of ISG20 1 0.01 0.76 0 5.00
131 INT187674 FSHR Positive_regulation of Gene_expression of CYP19A1 1 0.24 0 0 5.00
132 INT345484 Binding of MCL1 and PMAIP1 1 0.04 0.8 0 5.00
133 INT299285 SRC Regulation of Gene_expression of QPCT 1 0.03 0 0 5.00
134 INT268809 Binding of IFNA2 and PAEP 1 0.01 0.16 0 5.00
135 INT350984 Positive_regulation of VHL Positive_regulation of VEGFA 1 0.27 2.74 0 5.00
136 INT350983 TP53 Regulation of VEGFA 1 0.03 0.61 0 5.00
137 INT320824 VEGFA Positive_regulation of DLL4 1 0.40 0.41 0 5.00
138 INT299308 SRC Regulation of PI3 1 0.20 0 0 5.00
139 INT299295 OR3A4P Negative_regulation of Phosphorylation of AKT1 1 0.00 0.22 0 5.00
140 INT278068 Binding of XRCC1 and Vhl 1 0.02 2.3 0 5.00
141 INT283632 Binding of Selp and Ie 1 0.00 0.22 0 5.00
142 INT187667 DBT Positive_regulation of Localization of LEP 1 0.05 0.55 0 5.00
143 INT318787 Binding of AKT1 and VEGFA 1 0.37 0.34 0 5.00
144 INT299284 RICTOR Negative_regulation of PI3 1 0.18 0 0 5.00
145 INT278041 Binding of VEGFA and HCC 1 0.02 1.64 0 5.00
146 INT341856 Binding of EGFR and IgG1 1 0.27 1.12 0 5.00
147 INT299280 VEGFA Positive_regulation of RPTOR 1 0.29 0 0 5.00
148 INT299298 SRC Negative_regulation of PI3 1 0.19 0 0 5.00
149 INT264679 IGFALS Positive_regulation of CTSC 1 0.02 1.68 0 5.00
150 INT299279 AKT1 Negative_regulation of PI3 1 0.08 0 0 5.00
151 INT313384 Binding of PDLIM5 and ZMYND10 1 0.04 0.82 0 5.00
152 INT297615 Binding of TSC1 and HDAC9 1 0.01 0.4 0 5.00
153 INT299283 Binding of VEGFA and RPTOR 1 0.19 0 0 5.00
154 INT313885 XRCC1 Positive_regulation of Localization of PTEN 1 0.00 0.65 0 5.00
155 INT274385 Binding of ABAT and CDIPT 1 0.00 1.21 0 5.00
156 INT299301 VEGFA Positive_regulation of Positive_regulation of QPCT 1 0.02 0 0 5.00
157 INT345486 PMAIP1 Positive_regulation of Localization of CYC1 1 0.18 0.96 0 5.00
158 INT320825 VEGFA Positive_regulation of Gene_expression of DLL4 1 0.40 0.41 0 5.00
159 INT299294 SRC Regulation of VEGFA 1 0.20 0 0 5.00
160 INT347226 Hck Regulation of Gene_expression of Lyn 1 0.10 0.08 0 5.00
161 INT350982 TSHB Regulation of VEGFA 1 0.01 0.64 0 5.00
162 INT299287 Binding of VEGFA and QPCT 1 0.02 0 0 5.00
163 INT345483 Binding of MYC and PMAIP1 1 0.16 0.63 0 5.00
164 INT299290 Binding of VEGFA and RICTOR 1 0.16 0 0 5.00
165 INT187669 FSHR Positive_regulation of DBT 1 0.03 0 0 5.00
166 INT347225 Hck Regulation of Positive_regulation of Bcr 1 0.15 0.07 0 5.00
167 INT187673 GNRH1 Regulation of Localization of PLOD1 1 0.06 0.09 0 5.00
168 INT224307 Binding of HGFAC and CITED4 1 0.01 0.73 0 5.00
169 INT187670 Gene_expression of FSHR Positive_regulation of Gene_expression of CYP19A1 1 0.16 0 0 5.00
170 INT264678 Binding of SETX and KRT20 1 0.00 2.17 0 5.00
171 INT186449 Binding of SFTPB and SFTPC 1 0.38 0.09 0 5.00
172 INT299293 Binding of QPCT and RPTOR 1 0.02 0 0 5.00
173 INT278017 Ptprf Regulation of Igf1 1 0.48 0.31 0 5.00
174 INT283631 Positive_regulation of Binding of Cd36 and Ie 1 0.00 0 0 5.00
175 INT187668 Negative_regulation of GNRH1 Positive_regulation of PLOD1 1 0.06 0.07 0 5.00
176 INT350980 ESR1 Regulation of VEGFA 1 0.01 0.62 0 5.00
177 INT295426 Binding of KIT and PDGFRB 1 0.24 0.4 0 5.00
178 INT306764 Binding of Aes and ZMYND10 1 0.04 0.21 0 5.00
179 INT315867 Vhl Positive_regulation of Transcription of VEGFA 1 0.01 1.39 0 5.00
180 INT283629 Binding of Cd36 and Ie 1 0.00 0 0 5.00
181 INT277694 Cdkn1a Positive_regulation of Positive_regulation of Casp3 1 0.00 1.01 0 5.00
182 INT318806 Binding of VEGFA and NCOA1 1 0.00 0.22 0 5.00
183 INT211882 Binding of KIT and CDCP1 1 0.00 2.1 0 5.00
184 INT313884 XRCC1 Positive_regulation of Localization of HIF1A 1 0.00 0.65 0 5.00
185 INT264682 Binding of VAPB and SETX 1 0.28 1.09 0 5.00
186 INT345487 HIF1A Positive_regulation of PMAIP1 1 0.27 1.23 0 5.00
187 INT347224 Lyn Regulation of Positive_regulation of Bcr 1 0.14 0.07 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Asthenia. They are ordered first by their pain relevance and then by number of times they were reported in Asthenia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT188844 Gene_expression of AES 44 0.58 33.94 5.85 100.00
2 INT8669 Positive_regulation of Afp 66 0.70 58.21 7.67 99.84
3 INT170754 Localization of IFN1@ 121 0.78 66.78 15.6 99.52
4 INT3206 Positive_regulation of Got1 39 0.69 19.36 17.02 99.50
5 INT20260 Positive_regulation of Chkb 41 0.64 21.48 18.53 99.36
6 INT265083 Regulation of OR5BS1P 1 0.02 1.05 0.13 98.52
7 INT57252 Negative_regulation of PGR 22 0.43 12.95 3.33 98.04
8 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 98.00
9 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 97.76
10 INT95117 Gene_expression of PDGFA 71 0.71 51.17 6.9 97.76
11 INT95118 Negative_regulation of Gene_expression of PDGFA 4 0.54 5.03 0.76 97.76
12 INT2604 Positive_regulation of Got1 223 0.70 154.78 49.51 97.64
13 INT39518 Negative_regulation of HBN1 66 0.09 37.54 2.58 97.60
14 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67 97.32
15 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44 97.32
16 INT10916 Positive_regulation of BDNF-AS 39 0.49 25.88 5.28 96.72
17 INT304835 Positive_regulation of PMMoV 1 0.09 1.94 0.71 96.60
18 INT103779 Positive_regulation of MEMO1 2 0.01 3.77 0.3 96.32
19 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 96.08
20 INT1080 Negative_regulation of Ache 343 0.59 108.51 72.4 95.92
21 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 95.28
22 INT170333 Binding of IFN1@ 68 0.47 49.01 9.72 94.96
23 INT117083 Localization of RTEL1 5 0.60 9.1 0.8 94.88
24 INT260339 Positive_regulation of Gene_expression of Rcc1 1 0.11 2.28 0.15 94.60
25 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 94.56
26 INT186452 Positive_regulation of SFTPB 7 0.47 6.43 0.03 94.56
27 INT260340 Gene_expression of Rcc1 4 0.58 5.36 0.21 94.16
28 INT167964 Gene_expression of Aes 30 0.58 25.41 10.16 93.20
29 INT70134 Negative_regulation of TXK 124 0.23 81.96 9.59 93.16
30 INT17275 Gene_expression of HIVEP1 267 0.75 232.07 24.06 92.68
31 INT985 Negative_regulation of GH1 213 0.57 89.53 32.39 92.32
32 INT16964 Binding of IFNG 27 0.48 14.31 2.45 92.00
33 INT26917 Regulation of Adra1d 2 0.21 1.56 0.47 91.96
34 INT17913 Regulation of HSD11B1 87 0.60 93.23 6.04 91.92
35 INT95116 Negative_regulation of PDGFA 24 0.57 19.56 1.29 91.08
36 INT186459 Positive_regulation of SFTPC 4 0.45 4.64 0.36 91.00
37 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 90.68
38 INT158070 Localization of Aes 23 0.65 19.93 10.9 90.40
39 INT78509 Negative_regulation of SSBP 1 0.11 1.06 0.09 90.40
40 INT49284 Regulation of MYOM2 2 0.08 3.27 0.13 90.24
41 INT24080 Negative_regulation of Mtor 64 0.37 41.56 5.19 90.20
42 INT83236 Localization of PGR 14 0.73 8.26 2.23 90.04
43 INT14559 Gene_expression of Igf1 254 0.78 112 34.17 89.84
44 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 89.20
45 INT1894 Negative_regulation of Localization of Gh 168 0.58 64.12 43.56 89.08
46 INT1893 Localization of Gh 1041 0.79 340.23 256.58 88.68
47 INT200443 Positive_regulation of AES 27 0.60 22.46 3.22 87.68
48 INT109327 Negative_regulation of KIT 42 0.57 43.2 2.15 87.32
49 INT187717 Regulation of Negative_regulation of CYP19A1 11 0.42 2.85 0.45 87.20
50 INT45167 Positive_regulation of ASAP1 32 0.60 17.09 1.84 86.96
51 INT14724 Negative_regulation of CYP19A1 233 0.59 96.56 18.26 86.92
52 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 86.48
53 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79 86.32
54 INT15376 Positive_regulation of Gene_expression of ERBB2 215 0.70 168.54 5.23 86.32
55 INT46383 Negative_regulation of TRGC1 42 0.55 44.03 6.2 86.08
56 INT77281 Negative_regulation of HIVEP1 132 0.49 102.78 5.36 85.72
57 INT51837 Negative_regulation of TACR1 17 0.43 6.5 9.12 85.68
58 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 85.16
59 INT30738 Negative_regulation of Gene_expression of ALB 32 0.59 19.01 5.04 85.16
60 INT17685 Negative_regulation of Cog1 23 0.42 15.65 3.56 84.52
61 INT11934 Regulation of Sv2a 4 0.44 1.72 1.1 84.24
62 INT239496 Gene_expression of Aes 4 0.52 1.45 0.76 84.24
63 INT53574 Regulation of Tnf 45 0.62 40.68 19.71 83.16
64 INT50555 Regulation of Pthlh 3 0.16 2.07 0.52 83.16
65 INT47030 Negative_regulation of ARMC9 22 0.38 13.08 0.47 83.04
66 INT35175 Localization of IL18 18 0.80 12.96 3.83 82.92
67 INT3602 Negative_regulation of Shbg 148 0.53 69.05 11.65 82.16
68 INT186450 Negative_regulation of SFTPB 17 0.58 10.94 0.31 82.04
69 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 82.00
70 INT45489 Gene_expression of SRF 5 0.77 3.29 0.71 82.00
71 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 81.96
72 INT304836 Gene_expression of PMMoV 1 0.12 3.12 0.96 81.52
73 INT724 Negative_regulation of Alb 151 0.59 93.57 29.65 81.48
74 INT8637 Negative_regulation of Dbp 112 0.50 33.28 8.4 81.36
75 INT1793 Localization of CGA 379 0.81 67.38 114.69 81.12
76 INT33099 Negative_regulation of INSRR 32 0.40 13.82 9.85 80.92
77 INT955 Gene_expression of GHRH 126 0.78 59.91 20.74 80.84
78 INT22900 Positive_regulation of Cd4 126 0.67 82.77 16.43 80.44
79 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52 80.20
80 INT234409 Gene_expression of TSPYL2 2 0.21 5.16 0.03 80.00
81 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 79.64
82 INT297627 Positive_regulation of Gene_expression of RLN3 3 0.08 3.06 0.08 79.52
83 INT265661 Positive_regulation of Gene_expression of HIST2H4A 2 0.09 2.69 0.28 79.52
84 INT177759 Negative_regulation of IFN1@ 51 0.57 31.81 7.76 79.44
85 INT282777 Negative_regulation of Binding of IFN1@ 2 0.41 1.25 0 79.44
86 INT259250 Positive_regulation of XM 1 0.13 3.32 0.08 79.36
87 INT5055 Positive_regulation of IFNG 89 0.69 64.03 23.05 79.36
88 INT18012 Gene_expression of EPO 169 0.78 108.36 13.75 79.36
89 INT102659 Gene_expression of CSF3 32 0.77 21.93 2.39 79.36
90 INT13085 Positive_regulation of ACE 50 0.70 44.2 8.31 79.28
91 INT11160 Regulation of Gene_expression of EGFR 27 0.62 22.05 0.96 79.16
92 INT75742 Binding of RLS 86 0.42 95.27 19.04 79.12
93 INT745 Gene_expression of Afp 65 0.78 52.89 4.24 79.08
94 INT234614 Phosphorylation of KIT 6 0.78 4.85 0.23 78.80
95 INT3546 Binding of Oxt 54 0.48 9.75 10.81 78.68
96 INT5131 Gene_expression of GNRH1 109 0.78 28.79 23.94 78.60
97 INT14701 Negative_regulation of IFNA1 118 0.54 84.19 20.08 78.40
98 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 78.24
99 INT952 Negative_regulation of GHRH 57 0.56 25.3 10.34 78.08
100 INT274683 Localization of HIST2H4A 5 0.12 1.54 0 78.00
101 INT297624 Localization of RLN3 1 0.05 1 0 78.00
102 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 77.92
103 INT18522 Positive_regulation of Gene_expression of IFNA1 248 0.67 160.85 44.87 77.92
104 INT95852 Gene_expression of MIR378A 1 0.07 0.51 0.08 77.92
105 INT148291 Positive_regulation of CSF3 9 0.61 6.37 0.7 77.88
106 INT939 Gene_expression of PAEP 86 0.77 31.02 8.59 77.60
107 INT139527 Positive_regulation of Gene_expression of PAEP 16 0.43 4.66 0.98 77.60
108 INT121493 Gene_expression of XRCC1 55 0.65 73.43 2.76 77.44
109 INT200738 Gene_expression of HIST2H4A 7 0.18 4.65 0.91 77.04
110 INT83734 Negative_regulation of RLS 24 0.50 35.75 5.66 76.80
111 INT297626 Gene_expression of RLN3 3 0.11 5.07 0.3 76.48
112 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 76.44
113 INT4437 Positive_regulation of ABCB7 11 0.68 11.26 1.33 76.28
114 INT15872 Positive_regulation of EPO 74 0.70 45.35 6.67 76.20
115 INT69029 Gene_expression of PTPRC 127 0.75 74.26 11.57 75.80
116 INT230810 Phosphorylation of Ins1 59 0.69 41.15 4.51 75.28
117 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71 75.24
118 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26 75.00
119 INT8224 Gene_expression of CHGA 73 0.75 53.63 12.31 74.44
120 INT1982 Regulation of NARFL 119 0.49 116.2 14.35 74.24
121 INT232640 Binding of Jag2 1 0.12 4.1 0.49 73.92
122 INT78429 Positive_regulation of TRGC1 11 0.44 4.6 2.1 73.80
123 INT314336 Positive_regulation of Negative_regulation of TRGC1 2 0.41 2.23 0.21 73.80
124 INT56149 Localization of CD8A 56 0.74 30.41 5.75 73.76
125 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54 73.68
126 INT82611 Negative_regulation of SRC 30 0.57 20.16 5.47 73.68
127 INT52962 Binding of ERBB2 77 0.47 50.03 1.49 73.52
128 INT136503 Negative_regulation of KDR 46 0.48 43.1 1.86 73.44
129 INT5164 Negative_regulation of Ldlr 83 0.58 55.01 7.87 73.28
130 INT45753 Localization of CD40LG 45 0.79 32.31 5.28 73.28
131 INT215028 Phosphorylation of Gh 3 0.56 2.11 0.28 73.24
132 INT5219 Negative_regulation of DBP 43 0.57 23.35 4.26 72.96
133 INT253106 Negative_regulation of Phosphorylation of Ins1 6 0.17 5.62 0.87 72.92
134 INT105210 Positive_regulation of Adrm1 7 0.06 4.09 0.5 72.56
135 INT133567 Regulation of IL18 11 0.50 9.54 2.31 72.08
136 INT59010 Positive_regulation of Regulation of Crp 2 0.27 2.11 1.09 71.60
137 INT107129 Positive_regulation of RLS 46 0.60 40.1 8.09 71.56
138 INT37390 Regulation of Crp 39 0.46 28.74 11.45 71.20
139 INT531 Gene_expression of GH1 376 0.75 193.45 46.24 71.12
140 INT148721 Binding of PSMD1 13 0.31 4.78 1.76 70.36
141 INT11689 Binding of PSMD2 16 0.36 2.77 0.34 70.36
142 INT87029 Positive_regulation of Positive_regulation of IL2 8 0.50 8.17 1.36 69.92
143 INT10016 Negative_regulation of CD8A 81 0.42 56.68 13.15 69.88
144 INT19185 Negative_regulation of Cd4 80 0.51 61.32 8.51 69.88
145 INT4612 Positive_regulation of Localization of CGA 64 0.64 8.51 22.39 69.72
146 INT45155 Negative_regulation of Polymerase 18 0.51 15.18 1.38 69.64
147 INT193609 Protein_catabolism of HBEGF 4 0.30 2.77 0.3 69.44
148 INT16405 Regulation of CD8A 38 0.45 19.04 5.31 68.56
149 INT2262 Negative_regulation of Lhb 142 0.59 25.47 44.81 68.24
150 INT186458 Negative_regulation of SFTPC 11 0.57 8.6 1.29 68.20
151 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3 68.16
152 INT57162 Positive_regulation of Gene_expression of CDKN1A 64 0.68 35.3 9.69 68.16
153 INT299340 Negative_regulation of RPTOR 1 0.53 1.68 2.6 68.12
154 INT221508 Phosphorylation of IFN1@ 14 0.79 8.97 0.77 68.00
155 INT11439 Positive_regulation of Csf2 105 0.69 62.63 37.77 67.92
156 INT70987 Binding of RAC1 14 0.37 12.14 2.13 67.28
157 INT88051 Regulation of Gene_expression of IL2RG 2 0.24 1.57 0.65 67.12
158 INT52968 Regulation of Gene_expression of IL2RB 2 0.16 1.57 0 67.12
159 INT154358 Transcription of RLS 3 0.59 2.99 0.58 66.72
160 INT81396 Regulation of Gene_expression of ERBB2 14 0.43 10.73 0.74 66.32
161 INT96838 Negative_regulation of Gene_expression of ERBB2 25 0.57 15.83 1.34 66.32
162 INT295429 Positive_regulation of Phosphorylation of KIT 1 0.42 0.84 0.07 66.32
163 INT27628 Gene_expression of IL2RG 28 0.75 20.95 6.16 66.28
164 INT11049 Gene_expression of IL2RB 8 0.60 3.73 0.76 66.28
165 INT259251 Negative_regulation of DSN1 1 0.03 2.57 0.07 66.04
166 INT127686 Negative_regulation of KRT122P 3 0.32 3.02 0.38 65.52
167 INT48792 Regulation of ERBB2 48 0.57 36.56 1.8 65.44
168 INT439 Localization of Gnrh1 976 0.81 100.96 363.25 65.36
169 INT5127 Localization of Lhb 488 0.80 50.48 162.66 65.36
170 INT4289 Positive_regulation of Localization of Gnrh1 202 0.70 12.3 84.01 65.36
171 INT5711 Positive_regulation of Localization of Lhb 90 0.70 10.92 36.76 65.36
172 INT3725 Localization of Fshb 10 0.68 2.24 1.04 65.36
173 INT86945 Positive_regulation of Localization of Fshb 2 0.08 0.4 0.11 65.36
174 INT299342 Regulation of RPTOR 1 0.41 1.06 1.1 65.04
175 INT174868 Regulation of Negative_regulation of VEGFA 4 0.43 4.51 0.63 65.04
176 INT45818 Gene_expression of C4A 35 0.75 26.4 3.52 64.48
177 INT3880 Negative_regulation of Serping1 54 0.58 37.19 4.75 64.48
178 INT5148 Regulation of CD40LG 25 0.44 21.58 4.05 64.48
179 INT64843 Gene_expression of Serping1 19 0.67 8.88 2.72 64.48
180 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18 64.32
181 INT47459 Gene_expression of Rac1 101 0.68 45.27 24.33 64.32
182 INT23676 Gene_expression of Chrna7 47 0.75 23.66 9.51 64.32
183 INT6302 Binding of IFNA1 196 0.48 133.85 32.73 64.16
184 INT113420 Positive_regulation of Gene_expression of IL18 22 0.69 19.96 5.53 64.16
185 INT69036 Gene_expression of IL18 99 0.77 77.92 25.95 63.84
186 INT573 Negative_regulation of C3 60 0.59 41.37 7.78 63.80
187 INT5871 Binding of IFNA2 38 0.48 20.35 6.46 63.76
188 INT182899 Transcription of IFN1@ 17 0.69 4.91 1.75 63.52
189 INT3213 Gene_expression of Ins1 511 0.76 357.59 53.32 63.48
190 INT19330 Binding of HLA-A 99 0.48 76.26 22.85 63.44
191 INT22939 Gene_expression of Csf2 164 0.78 85.1 32.22 63.16
192 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 63.04
193 INT209033 Positive_regulation of Localization of IFN1@ 27 0.67 12.55 2.84 62.96
194 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9 62.92
195 INT175416 Regulation of Negative_regulation of EGFR 4 0.60 3.94 0.14 62.48
196 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 62.24
197 INT27935 Binding of Vim 21 0.36 15.65 2.61 62.20
198 INT175652 Positive_regulation of BPHL 9 0.44 17.98 1.14 62.20
199 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 62.16
200 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 62.08
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