D:Atrial Heart Septal Defects

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Disease Term
Synonyms Atrial Septal Defect, Atrial Septal Defects, Defect Atrial Septal, Defects Atrial Septal, Ostium Primum Persistent, Ostium Secundum Atrial Septal Defect, Persistent Ostium Primum, Primum Persistent Ostium, Septal Defect Atrial, Septal Defects Atrial
Documents 76
Hot Single Events 15
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Atrial Heart Septal Defects. They are ordered first by their relevance to Atrial Heart Septal Defects and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT279889 Il6 Regulation of Socs3 1 0.21 0.17 0.05 5.00
2 INT279885 Ctcf Regulation of H19 1 0.12 0 0 5.00
3 INT274435 Binding of Zfpm2 and Mir130a 1 0.30 0.26 0 5.00
4 INT279891 Shbdp1 Negative_regulation of PCDHB@ 1 0.01 0.09 0 5.00
5 INT274432 Mir130a Regulation of Zfpm2 1 0.22 0.08 0 5.00
6 INT279886 Shbdp1 Negative_regulation of Pcdhb1 1 0.10 0.09 0 5.00
7 INT256210 NPPB Regulation of PVR 1 0.24 1.14 0 5.00
8 INT274431 Mir130a Regulation of Gene_expression of Zfpm2 1 0.50 0.79 0 5.00
9 INT274434 Binding of Gata4 and Zfpm2 1 0.12 0.56 0 5.00
10 INT279884 Nipbl Regulation of Transcription of Pcdhb1 1 0.25 0.05 0 5.00
11 INT279892 Shbdp1 Negative_regulation of Gene_expression of PCDHB@ 1 0.01 0.09 0 5.00
12 INT256209 AVP Regulation of PVR 1 0.06 0.99 0 5.00
13 INT274433 Binding of Zfpm2 and Uts2r 1 0.08 0.17 0 5.00
14 INT193147 CRAMP1L Regulation of TSPO 1 0.01 0.27 0 5.00
15 INT274436 Mir130a Regulation of Transcription of Zfpm2 1 0.22 0 0 5.00
16 INT279888 Binding of Rec8 and Nipbl 1 0.01 0.81 0 5.00
17 INT256211 NPPB Regulation of PDAP1 1 0.28 1.14 0 5.00
18 INT279890 Nipbl Regulation of Gene_expression of PCDHB@ 1 0.07 0.1 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Atrial Heart Septal Defects. They are ordered first by their pain relevance and then by number of times they were reported in Atrial Heart Septal Defects. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT151743 Binding of Gusb 11 0.24 8.73 1.63 100.00
2 INT104284 Positive_regulation of Notch3 7 0.50 5.57 0.99 99.36
3 INT274417 Negative_regulation of Zfpm2 1 0.43 6.99 0 98.28
4 INT83734 Negative_regulation of RLS 24 0.50 35.75 5.66 95.84
5 INT193154 Regulation of CRAMP1L 5 0.28 3.04 0.34 93.96
6 INT193157 Regulation of Gene_expression of CRAMP1L 1 0.12 1.35 0 93.96
7 INT62827 Positive_regulation of ICAM1 184 0.70 180.95 36.28 93.68
8 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 93.68
9 INT67981 Positive_regulation of CCL2 165 0.70 136.84 61.85 93.68
10 INT63340 Positive_regulation of Gene_expression of ICAM1 109 0.70 90.82 20.61 93.68
11 INT117470 Positive_regulation of Positive_regulation of ISYNA1 7 0.51 6.87 1.94 93.68
12 INT193156 Gene_expression of CRAMP1L 17 0.42 10.96 0.18 93.56
13 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02 87.60
14 INT274405 Gene_expression of Zfpm2 1 0.77 6.51 0 84.80
15 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 83.56
16 INT76095 Positive_regulation of ISYNA1 117 0.55 79.73 25.86 79.56
17 INT166702 Negative_regulation of Ier2 2 0.20 1.62 0.61 76.56
18 INT118267 Negative_regulation of ARSD 14 0.36 8.27 1.44 75.00
19 INT154229 Gene_expression of ARSD 22 0.57 12.5 6.19 75.00
20 INT108501 Binding of ARSD 14 0.32 11.5 2.93 75.00
21 INT59859 Localization of ARSD 11 0.65 9.67 1.88 75.00
22 INT132702 Binding of ASD1 2 0.03 1.71 0.63 75.00
23 INT154230 Regulation of Gene_expression of ARSD 2 0.35 1.01 0.14 75.00
24 INT274421 Gene_expression of Mir130a 1 0.55 15.48 0 73.20
25 INT21032 Gene_expression of Adh1 23 0.78 22.1 6.14 61.64
26 INT13406 Negative_regulation of CASP1 25 0.57 10.61 6.36 59.40
27 INT162831 Regulation of ARSD 13 0.35 6.17 1.19 56.08
28 INT683 Positive_regulation of AVP 173 0.70 74.55 46.41 53.32
29 INT21632 Positive_regulation of Adh1 32 0.70 15.67 11.65 52.44
30 INT59283 Positive_regulation of Gene_expression of Plg 6 0.25 2.36 1.97 51.28
31 INT10145 Gene_expression of Plg 28 0.62 12.68 7.46 50.92
32 INT279853 Negative_regulation of Gene_expression of Nipbl 1 0.51 2.37 0.19 46.24
33 INT279846 Gene_expression of Nipbl 1 0.68 11.1 0.56 46.04
34 INT39640 Negative_regulation of Gene_expression of Plg 2 0.25 1.13 0.39 45.08
35 INT22429 Positive_regulation of PDAP1 34 0.61 22.58 2.91 41.36
36 INT449 Localization of PDAP1 4 0.66 2.29 0.33 38.88
37 INT274406 Negative_regulation of Mir130a 1 0.31 0.4 0 28.80
38 INT279862 Binding of Nipbl 1 0.36 1.22 0.04 26.32
39 INT67133 Gene_expression of Gusb 14 0.75 18.57 1.37 8.72
40 INT67134 Positive_regulation of Gene_expression of Gusb 3 0.34 1.37 0.05 8.72
41 INT28929 Negative_regulation of PVR 22 0.57 16.64 1.07 6.84
42 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
43 INT86521 Gene_expression of Lpar1 167 0.78 154.61 80.35 5.00
44 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 5.00
45 INT3679 Gene_expression of AVP 171 0.78 72.9 35.23 5.00
46 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19 5.00
47 INT76336 Negative_regulation of PDE5A 192 0.59 112.02 20.09 5.00
48 INT170051 Positive_regulation of Gene_expression of Gopc 150 0.43 56.75 16.93 5.00
49 INT9191 Localization of EDN1 94 0.81 57.01 14.78 5.00
50 INT8904 Positive_regulation of Gene_expression of EDN1 66 0.70 65.4 14.42 5.00
51 INT54924 Gene_expression of RLS 67 0.62 83.2 14.25 5.00
52 INT10139 Positive_regulation of F13A1 64 0.56 44.75 9.69 5.00
53 INT131788 Positive_regulation of NPPB 87 0.67 86.1 8.81 5.00
54 INT228870 Negative_regulation of Lpar1 17 0.51 20.97 8.77 5.00
55 INT34767 Gene_expression of PTGIR 36 0.42 14.79 6.69 5.00
56 INT62950 Gene_expression of NPPB 73 0.75 65.91 6.54 5.00
57 INT119523 Gene_expression of EDNRB 32 0.75 26.47 5.75 5.00
58 INT60776 Regulation of EDNRA 20 0.51 16.62 5.36 5.00
59 INT78393 Gene_expression of Adm 16 0.78 8.4 4.92 5.00
60 INT7298 Gene_expression of NPPA 35 0.70 18.23 4.76 5.00
61 INT111739 Negative_regulation of Npy 15 0.43 4.9 4.65 5.00
62 INT94303 Gene_expression of Upf1 44 0.04 11.62 3.87 5.00
63 INT61680 Positive_regulation of PVR 23 0.60 23.27 3.86 5.00
64 INT176892 Binding of MR1 36 0.32 15.55 2.58 5.00
65 INT103095 Binding of ISYNA1 10 0.28 6.17 2.03 5.00
66 INT203814 Gene_expression of Lna1 8 0.65 6.48 1.95 5.00
67 INT10976 Negative_regulation of ENPP3 13 0.42 5.11 1.92 5.00
68 INT14184 Positive_regulation of CPB1 23 0.55 14.38 1.73 5.00
69 INT176888 Positive_regulation of MR1 29 0.67 11.68 1.71 5.00
70 INT119346 Positive_regulation of PTGIR 9 0.58 6.2 1.61 5.00
71 INT35132 Gene_expression of PDAP1 18 0.52 9.05 1.5 5.00
72 INT59837 Regulation of Upf1 5 0.03 1.37 1.45 5.00
73 INT103907 Negative_regulation of Upf1 15 0.37 4.3 1.4 5.00
74 INT16854 Gene_expression of Uts2r 17 0.26 3.1 1.31 5.00
75 INT203640 Regulation of MR1 7 0.34 3.8 1.26 5.00
76 INT79598 Regulation of PDE5A 16 0.60 8.68 1.17 5.00
77 INT15746 Negative_regulation of PDAP1 13 0.52 6.45 1.12 5.00
78 INT135039 Gene_expression of Cd1 11 0.60 5.66 1.05 5.00
79 INT116797 Gene_expression of Osmr 9 0.73 1.12 1 5.00
80 INT129971 Regulation of PVR 5 0.60 3.96 0.97 5.00
81 INT139515 Positive_regulation of EDNRB 15 0.67 10.35 0.93 5.00
82 INT95561 Negative_regulation of Vldlr 9 0.53 2.59 0.84 5.00
83 INT15819 Negative_regulation of RBP1 4 0.56 2.58 0.83 5.00
84 INT105344 Gene_expression of Cited2 5 0.78 3.65 0.76 5.00
85 INT64096 Negative_regulation of AHR 5 0.37 1.2 0.58 5.00
86 INT200247 Negative_regulation of Dbp 5 0.15 0.8 0.5 5.00
87 INT178834 Localization of MR1 8 0.21 6.52 0.48 5.00
88 INT225355 Gene_expression of Set 15 0.37 2.98 0.47 5.00
89 INT178830 Negative_regulation of MR1 16 0.50 7.63 0.44 5.00
90 INT279847 Negative_regulation of Cebpb 2 0.28 1.82 0.44 5.00
91 INT238058 Negative_regulation of Shbdp1 4 0.10 1.36 0.42 5.00
92 INT164328 Negative_regulation of SMARCB1 8 0.24 4.04 0.4 5.00
93 INT179214 Binding of AMIGO2 4 0.32 3.9 0.35 5.00
94 INT181059 Gene_expression of Rnase1 5 0.25 0.98 0.19 5.00
95 INT300167 Binding of FBXL15 2 0.39 5 0.19 5.00
96 INT242346 Negative_regulation of Positive_regulation of PDAP1 2 0.45 2.43 0.15 5.00
97 INT143838 Gene_expression of Pitx2 3 0.53 1.86 0.09 5.00
98 INT279840 Positive_regulation of Gene_expression of Nipbl 1 0.44 0.22 0.07 5.00
99 INT279851 Positive_regulation of Nipbl 1 0.44 0.19 0.04 5.00
100 INT205998 Binding of PDAP1 3 0.33 2.66 0.03 5.00
101 INT279869 Negative_regulation of Nipbl 1 0.43 4.3 0.03 5.00
102 INT279854 Gene_expression of Ptx3 1 0.48 0.17 0.03 5.00
103 INT244771 Gene_expression of Satb2 4 0.68 1.27 0.03 5.00
104 INT211830 Binding of PVR 3 0.32 2.26 0.03 5.00
105 INT279866 Regulation of Stag1 1 0.38 0.09 0 5.00
106 INT279868 Positive_regulation of Positive_regulation of Pcdhb1 1 0.47 0.08 0 5.00
107 INT279831 Positive_regulation of Lias 1 0.01 0.26 0 5.00
108 INT274420 Positive_regulation of Gene_expression of Zfpm2 1 0.49 0.51 0 5.00
109 INT279856 Regulation of Pcdhb1 1 0.42 0.89 0 5.00
110 INT274426 Regulation of Binding of Mir130a 1 0.32 0.41 0 5.00
111 INT274416 Localization of Mir208a 1 0.16 0.54 0 5.00
112 INT279834 Negative_regulation of Pcdhb7 1 0.30 0.09 0 5.00
113 INT279881 Negative_regulation of Gene_expression of PCDHB@ 1 0.05 0.09 0 5.00
114 INT274424 Gene_expression of Tbx20 1 0.05 0.27 0 5.00
115 INT279845 Regulation of Nipbl 1 0.39 0.28 0 5.00
116 INT279839 Regulation of Transcription of Pcdhb1 1 0.42 0.05 0 5.00
117 INT279841 Transcription of Nipbl 1 0.63 1.21 0 5.00
118 INT279857 Localization of Nipbl 1 0.65 0 0 5.00
119 INT274412 Transcription of Zfpm2 1 0.53 0 0 5.00
120 INT279861 Positive_regulation of Gene_expression of Rnase1 1 0.15 0 0 5.00
121 INT279858 Gene_expression of Tcof1 1 0.40 0.47 0 5.00
122 INT279860 Binding of Pcdhb7 1 0.26 0.09 0 5.00
123 INT274418 Regulation of Gene_expression of Zfpm2 1 0.45 1.42 0 5.00
124 INT274404 Binding of Gata4 2 0.16 0.89 0 5.00
125 INT274428 Regulation of Binding of Zfpm2 1 0.45 0.15 0 5.00
126 INT279832 Gene_expression of Pcdhb1 1 0.72 0.06 0 5.00
127 INT279870 Transcription of Hbb-bh1 1 0.25 0 0 5.00
128 INT279833 Transcription of Pcdhb1 1 0.67 0 0 5.00
129 INT279882 Regulation of PCDHB@ 1 0.06 0.89 0 5.00
130 INT274403 Gene_expression of Mir375 7 0.11 1.07 0 5.00
131 INT279864 Regulation of Ctcf 1 0.14 0.18 0 5.00
132 INT274425 Negative_regulation of Gene_expression of Zfpm2 1 0.42 0.06 0 5.00
133 INT274411 Positive_regulation of Zfpm2 1 0.46 0.53 0 5.00
134 INT279867 Binding of Rec8 1 0.01 0.81 0 5.00
135 INT274415 Regulation of Gene_expression of Lna1 1 0.44 0.26 0 5.00
136 INT279849 Binding of Pds5b 1 0.32 0.93 0 5.00
137 INT274429 Gene_expression of Mir24-1 7 0.20 5.43 0 5.00
138 INT279883 Gene_expression of PCDHB@ 1 0.10 0.19 0 5.00
139 INT274407 Positive_regulation of Gene_expression of Mir130a 1 0.49 5.1 0 5.00
140 INT279871 Negative_regulation of Transcription of Nipbl 1 0.43 1.22 0 5.00
141 INT274422 Negative_regulation of Localization of Mir208a 1 0.09 0.55 0 5.00
142 INT279855 Positive_regulation of Pcdhb1 1 0.47 0.08 0 5.00
143 INT279830 Regulation of Transcription of Nipbl 1 0.39 0.62 0 5.00
144 INT279835 Regulation of Transcription of Hbb-bh1 1 0.16 0 0 5.00
145 INT274414 Regulation of Zfpm2 1 0.61 0.59 0 5.00
146 INT274409 Negative_regulation of Gene_expression of Tbx20 1 0.03 0.27 0 5.00
147 INT279850 Gene_expression of Trps1 1 0.38 0.47 0 5.00
148 INT279837 Regulation of Gene_expression of Nipbl 1 0.39 0 0 5.00
149 INT274419 Regulation of Gene_expression of Mir130a 1 0.32 1.02 0 5.00
150 INT279843 Negative_regulation of Ebf1 1 0.37 0.6 0 5.00
151 INT274408 Binding of Zfpm2 1 0.37 0.77 0 5.00
152 INT193155 Gene_expression of PTP4A2 1 0.47 0.2 0 5.00
153 INT274427 Negative_regulation of Gene_expression of Mir130a 1 0.30 0.14 0 5.00
154 INT279865 Transcription of Ctcf 1 0.36 0 0 5.00
155 INT193152 Positive_regulation of CRAMP1L 1 0.13 0 0 5.00
156 INT274413 Regulation of Mir130a 1 0.32 0.21 0 5.00
157 INT279838 Protein_catabolism of Rec8 1 0.02 0.81 0 5.00
158 INT274423 Positive_regulation of Gene_expression of Uts2r 3 0.09 0.58 0 5.00
159 INT274410 Binding of Mir130a 1 0.27 0.66 0 5.00
160 INT279859 Regulation of Pcdhb2 1 0.54 0 0 5.00
161 INT279863 Localization of Pds5a 1 0.47 0.93 0 5.00
162 INT279844 Localization of Pds5b 1 0.65 0.94 0 5.00
163 INT279842 Regulation of Rec8 1 0.01 0.6 0 5.00
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