D:Atrophy

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pChart

Disease Term
Synonyms Atrophies
Documents 49
Hot Single Events 32
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Atrophy. They are ordered first by their relevance to Atrophy and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT206764 Binding of AQP4 and Nqo1 8 0.05 13.45 2.84 5.00
2 INT140172 Binding of Nqo1 and IgG 5 0.17 6.68 1.2 5.00
3 INT235975 Binding of AQP4 and IgG 2 0.04 4.11 0.53 5.00
4 INT291616 Cby1 Positive_regulation of Gene_expression of Smad7 1 0.00 0.79 0.38 5.00
5 INT327789 Binding of IgG and Alms1 1 0.01 1.1 0.17 5.00
6 INT327790 Binding of Nqo1 and Alms1 1 0.00 1.1 0.17 5.00
7 INT327791 Binding of AQP4 and Alms1 1 0.03 1.1 0.17 5.00
8 INT327792 Binding of IGFALS and Alms1 1 0.00 1.15 0.11 5.00
9 INT274233 Negative_regulation of Binding of Cd4 and Fasl 1 0.13 0.91 0.08 5.00
10 INT274232 Binding of Cd4 and Fasl 1 0.11 0.9 0.08 5.00
11 INT274231 Fasl Positive_regulation of Gene_expression of Cd8a 1 0.03 1.01 0.07 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Atrophy. They are ordered first by their pain relevance and then by number of times they were reported in Atrophy. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT140413 Gene_expression of AQP4 113 0.78 139.25 25.53 99.88
2 INT251679 Negative_regulation of Gene_expression of AQP4 2 0.38 10.37 0.77 99.88
3 INT327779 Regulation of Gene_expression of AQP4 5 0.48 4.5 0.6 99.88
4 INT327788 Regulation of Regulation of AQP4 1 0.21 0.75 0 99.40
5 INT13186 Positive_regulation of Il4 113 0.68 71.22 31.4 99.36
6 INT116143 Positive_regulation of Casp9 32 0.67 30.34 3.04 99.36
7 INT65500 Gene_expression of App 605 0.78 429.94 98.31 99.28
8 INT89662 Positive_regulation of Gene_expression of App 169 0.70 133.36 25.62 99.28
9 INT1472 Positive_regulation of Ins1 349 0.69 146.2 86.36 99.12
10 INT264689 Negative_regulation of IGFALS 10 0.33 12.58 0.45 98.96
11 INT240278 Localization of IGFALS 11 0.53 9.44 0.29 98.96
12 INT169747 Localization of AQP4 17 0.75 16.64 2.79 98.86
13 INT87235 Negative_regulation of Il4 54 0.48 31.51 13.15 98.36
14 INT327783 Regulation of Transcription of AQP4 1 0.35 1.03 0 98.12
15 INT327785 Transcription of AQP4 3 0.56 2.19 0.23 98.12
16 INT157960 Regulation of AQP4 11 0.48 21.36 3.06 97.84
17 INT196710 Positive_regulation of VMO1 9 0.64 3.49 3.08 96.88
18 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03 94.96
19 INT81626 Positive_regulation of Positive_regulation of Casp3 34 0.69 16.75 12.18 94.96
20 INT265514 Negative_regulation of COX1 1 0.42 0.82 0 94.72
21 INT250282 Negative_regulation of AQP4 32 0.54 32.96 9.07 94.08
22 INT196708 Negative_regulation of VMO1 2 0.34 0.92 0.83 93.80
23 INT237247 Regulation of Mri1 6 0.27 4.64 1.2 93.76
24 INT27595 Negative_regulation of EMG1 14 0.38 4.26 3.61 93.00
25 INT293883 Positive_regulation of SLA 1 0.25 0.34 0.07 91.96
26 INT196714 Binding of VMO1 4 0.30 1.51 1.46 88.92
27 INT115386 Gene_expression of Ppara 779 0.77 549.99 128.36 87.84
28 INT274229 Negative_regulation of Tnnc2 1 0.11 0.8 0.04 85.84
29 INT15684 Positive_regulation of Serpine1 65 0.70 43.51 13.67 85.08
30 INT232634 Localization of Opa1 2 0.75 1.11 0 84.60
31 INT5135 Negative_regulation of GNRH1 106 0.58 36.63 27.71 84.52
32 INT796 Gene_expression of Penk 1902 0.78 275.47 1057.59 80.80
33 INT1753 Gene_expression of Ache 38 0.78 15.31 4.58 79.88
34 INT8777 Positive_regulation of Ache 25 0.68 7.77 3.18 79.88
35 INT122039 Positive_regulation of Gene_expression of Ppara 144 0.68 113.55 28.55 78.84
36 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 77.84
37 INT20380 Gene_expression of Il5 172 0.78 104.75 34.78 77.84
38 INT51741 Regulation of Gene_expression of Il4 23 0.36 12.7 7.39 77.84
39 INT142147 Regulation of Gene_expression of Il5 4 0.22 1.58 1.07 77.84
40 INT196712 Positive_regulation of Positive_regulation of VMO1 1 0.55 0.55 0.42 77.28
41 INT98225 Regulation of Il5 8 0.45 5.07 2.06 76.96
42 INT79693 Regulation of Il4 30 0.51 21.96 8.6 76.24
43 INT254811 Localization of Col1a1 3 0.29 1.39 0.3 76.24
44 INT291615 Negative_regulation of Localization of Col1a1 1 0.06 1.28 0.3 76.24
45 INT63975 Positive_regulation of Il10 175 0.68 134.13 54.69 76.16
46 INT126513 Gene_expression of Col1a1 23 0.75 10.92 2.18 75.12
47 INT126512 Negative_regulation of Gene_expression of Col1a1 3 0.39 2.2 0.27 75.12
48 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38 74.68
49 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 73.80
50 INT54302 Positive_regulation of Gene_expression of Il4 126 0.68 86.18 30.75 73.80
51 INT126984 Positive_regulation of Gene_expression of Il5 29 0.69 20.61 6.72 73.80
52 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 73.40
53 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 72.72
54 INT728 Positive_regulation of Penk 1068 0.70 186.9 636.87 72.36
55 INT265513 Binding of Opa1 2 0.48 5.75 0 71.44
56 INT104395 Gene_expression of Cxcl9 83 0.76 73.1 19.79 70.32
57 INT315360 Negative_regulation of Negative_regulation of ELN 1 0.02 0.94 0.06 70.24
58 INT1395 Negative_regulation of Penk 537 0.59 87.33 389.81 70.16
59 INT11807 Gene_expression of Il2 266 0.78 112 64.97 68.56
60 INT283110 Localization of Dag1 5 0.73 3.14 0.61 68.56
61 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 68.32
62 INT34729 Positive_regulation of IFN1@ 233 0.67 128.04 30.38 68.32
63 INT192409 Positive_regulation of Gene_expression of IFN1@ 102 0.67 64.66 18.8 68.32
64 INT26282 Negative_regulation of ELN 9 0.51 6.37 3.76 66.56
65 INT1114 Localization of Ins1 748 0.80 192.95 165.48 65.96
66 INT271775 Positive_regulation of Gene_expression of Ache 3 0.69 5.16 0.34 63.00
67 INT274230 Localization of Tnnc2 1 0.14 0.56 0 62.00
68 INT98554 Positive_regulation of Casp8 20 0.67 21.32 2.9 60.48
69 INT109973 Positive_regulation of Tnfrsf21 4 0.19 4.06 1.78 60.48
70 INT70814 Negative_regulation of Il2 40 0.56 13.36 7.22 59.20
71 INT20102 Gene_expression of Serpine1 102 0.78 65.99 12.61 54.20
72 INT84546 Positive_regulation of Ppara 481 0.70 334.21 83.45 53.68
73 INT71115 Positive_regulation of Gene_expression of Serpine1 20 0.70 15.32 1.97 53.52
74 INT256399 Positive_regulation of ND4 1 0.01 1.36 0 52.24
75 INT250272 Positive_regulation of Gene_expression of AQP4 11 0.54 9.79 1.85 51.64
76 INT90792 Localization of Il10 144 0.80 87.88 30.03 49.60
77 INT20379 Localization of Il4 85 0.73 51.22 20.55 49.60
78 INT170754 Localization of IFN1@ 121 0.78 66.78 15.6 49.60
79 INT211701 Positive_regulation of Mri1 20 0.34 20.64 6.69 46.12
80 INT28576 Binding of MLN 18 0.48 5.45 2.26 45.52
81 INT52047 Gene_expression of APOE 50 0.78 34.75 3.52 45.20
82 INT140414 Positive_regulation of AQP4 25 0.64 23.43 2.47 44.64
83 INT95414 Positive_regulation of Alms1 40 0.41 20.3 8.1 43.24
84 INT137614 Gene_expression of Lgals3 70 0.77 66.13 12.53 42.16
85 INT123885 Positive_regulation of Lgals3 23 0.57 24.38 6.32 42.16
86 INT252209 Positive_regulation of Gene_expression of Lgals3 10 0.57 8.29 1.62 42.16
87 INT10478 Protein_catabolism of Alms1 25 0.47 12.95 7.19 42.04
88 INT175580 Localization of APOE 10 0.76 18.84 0.65 41.28
89 INT39758 Gene_expression of Fn1 57 0.65 34.38 6.02 38.64
90 INT92835 Gene_expression of Col4a1 22 0.49 13.5 2.27 38.64
91 INT170314 Positive_regulation of Gene_expression of Col4a1 7 0.18 3.52 0.49 38.64
92 INT75932 Binding of Csf2 45 0.37 33.2 8.01 37.44
93 INT181386 Positive_regulation of Cxcl12 12 0.69 15.35 2.84 37.36
94 INT274228 Positive_regulation of Positive_regulation of Cxcl12 4 0.44 2.82 0.23 37.36
95 INT240281 Positive_regulation of IGFALS 11 0.31 10.44 0.56 34.56
96 INT264686 Positive_regulation of Gene_expression of IGFALS 2 0.28 2.21 0.27 34.56
97 INT240280 Gene_expression of IGFALS 14 0.42 20.38 0.95 33.04
98 INT39919 Negative_regulation of MLN 9 0.36 2.91 1.06 32.40
99 INT79902 Gene_expression of AQP1 33 0.78 24.72 4.55 24.84
100 INT15941 Negative_regulation of Serpine1 42 0.58 21.07 4.95 20.60
101 INT19393 Gene_expression of Gfm1 31 0.51 18.9 3.2 15.44
102 INT127714 Negative_regulation of GEM 6 0.37 2.24 1.01 14.88
103 INT22389 Regulation of MLN 9 0.61 4.39 3.08 14.68
104 INT36177 Binding of Alms1 70 0.31 35.47 13.81 10.60
105 INT230495 Regulation of Gene_expression of Alms1 4 0.04 4.53 0.53 6.92
106 INT327784 Regulation of Gene_expression of IGFALS 1 0.07 1.21 0.13 6.92
107 INT24225 Gene_expression of Alms1 93 0.62 52.75 16.93 6.32
108 INT5207 Negative_regulation of Alms1 70 0.41 41.56 13.68 6.32
109 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
110 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
111 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 5.00
112 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 5.00
113 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
114 INT77855 Gene_expression of Pain1 55 0.75 67.42 54.1 5.00
115 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 5.00
116 INT29743 Negative_regulation of App 91 0.59 65.56 31.26 5.00
117 INT5117 Negative_regulation of Gene_expression of IL2 118 0.59 52.33 29.96 5.00
118 INT6660 Positive_regulation of Jun 148 0.69 67.58 29.73 5.00
119 INT66200 Gene_expression of Gfap 215 0.78 88.04 28.25 5.00
120 INT115385 Negative_regulation of Ppara 154 0.58 129.05 27.58 5.00
121 INT93626 Gene_expression of Fasl 118 0.75 115.24 25.11 5.00
122 INT8775 Binding of IGHE 167 0.48 102.61 23.54 5.00
123 INT11625 Localization of App 98 0.78 55.46 20.86 5.00
124 INT111401 Positive_regulation of Gene_expression of Tg(CAG-EGFP)D4Nagy 134 0.61 34.87 20.15 5.00
125 INT16794 Binding of App 103 0.48 64.87 19.79 5.00
126 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 5.00
127 INT22900 Positive_regulation of Cd4 126 0.67 82.77 16.43 5.00
128 INT1752 Negative_regulation of Ache 109 0.59 42.05 15.73 5.00
129 INT81627 Gene_expression of Fas 120 0.78 115.51 15.36 5.00
130 INT81629 Positive_regulation of Fas 58 0.70 59.63 12.94 5.00
131 INT93620 Positive_regulation of Gene_expression of Fasl 51 0.66 59.45 12.04 5.00
132 INT35164 Negative_regulation of IGHE 96 0.58 76.3 9.74 5.00
133 INT46273 Gene_expression of PRNP 103 0.78 110.34 9.25 5.00
134 INT20664 Binding of ACE 60 0.48 35.27 9.16 5.00
135 INT20371 Gene_expression of Cd8a 125 0.60 67.59 8.97 5.00
136 INT140411 Gene_expression of Nqo1 45 0.60 62.35 8.7 5.00
137 INT20205 Binding of IgG 108 0.46 66.68 8.57 5.00
138 INT725 Negative_regulation of IgG 62 0.41 37.21 8.16 5.00
139 INT2971 Regulation of IGHE 42 0.61 28.81 7.87 5.00
140 INT157959 Binding of AQP4 32 0.48 43.44 7.44 5.00
141 INT99942 Positive_regulation of Fasl 37 0.68 32.61 6.92 5.00
142 INT140170 Binding of Nqo1 24 0.38 36.16 6.79 5.00
143 INT50255 Regulation of Cd4 39 0.49 29.73 6.77 5.00
144 INT168641 Gene_expression of Iba1 24 0.63 12.21 6.7 5.00
145 INT84704 Positive_regulation of Nqo1 18 0.70 18.64 5.65 5.00
146 INT93484 Negative_regulation of Positive_regulation of Jun 30 0.58 9.31 5.18 5.00
147 INT89546 Phosphorylation of NEFH 10 0.76 3.49 5.08 5.00
148 INT168640 Positive_regulation of Gene_expression of Iba1 9 0.33 8.3 4.55 5.00
149 INT81628 Positive_regulation of Gene_expression of Fas 32 0.67 38.13 4.23 5.00
150 INT72747 Localization of IgG 55 0.53 30.88 4.19 5.00
151 INT116622 Positive_regulation of Nefh 17 0.39 11.98 3.86 5.00
152 INT115890 Gene_expression of Nefh 28 0.68 11.55 3.84 5.00
153 INT120072 Gene_expression of Smad7 38 0.74 20.87 3.69 5.00
154 INT36799 Negative_regulation of Ighm 21 0.41 17.47 3.65 5.00
155 INT11627 Positive_regulation of Localization of App 14 0.62 6.27 3.64 5.00
156 INT51848 Transcription of TGFB1 17 0.69 9.57 3.53 5.00
157 INT188406 Binding of Fasl 19 0.44 24.67 3.17 5.00
158 INT206760 Localization of Nqo1 8 0.09 15.76 2.4 5.00
159 INT194504 Gene_expression of Smad2 27 0.65 7.45 2.25 5.00
160 INT237252 Localization of Mri1 7 0.45 4.42 2.23 5.00
161 INT2611 Negative_regulation of AQP1 17 0.39 10.04 2.15 5.00
162 INT23188 Localization of Serpine1 22 0.79 16.06 1.96 5.00
163 INT167035 Regulation of Cd8a 25 0.41 16.78 1.9 5.00
164 INT47714 Regulation of Nqo1 12 0.24 11.12 1.71 5.00
165 INT77818 Positive_regulation of EMG1 24 0.54 2.73 1.59 5.00
166 INT255251 Negative_regulation of Smad2 12 0.32 5.69 1.44 5.00
167 INT211054 Positive_regulation of AQP1 3 0.33 4.53 1.41 5.00
168 INT116625 Phosphorylation of Nefh 13 0.79 5.94 1.4 5.00
169 INT141131 Positive_regulation of Gene_expression of PRNP 12 0.61 16.6 1.36 5.00
170 INT239215 Binding of Agt 9 0.38 6.75 1.35 5.00
171 INT181509 Negative_regulation of Psen1 17 0.57 11.53 1.35 5.00
172 INT129619 Phosphorylation of Smad2 34 0.61 11.6 1.34 5.00
173 INT128061 Negative_regulation of Gene_expression of Serpine1 16 0.43 13.13 1.29 5.00
174 INT106709 Binding of LAMB2 13 0.06 4.89 1.26 5.00
175 INT154095 Positive_regulation of Gene_expression of Nefh 6 0.58 5.35 1.01 5.00
176 INT166889 Positive_regulation of Gene_expression of AQP1 10 0.70 6.43 0.99 5.00
177 INT178175 Positive_regulation of Gene_expression of Cd8a 17 0.43 13.05 0.78 5.00
178 INT291617 Negative_regulation of Transcription of TGFB1 2 0.15 0.61 0.76 5.00
179 INT17470 Negative_regulation of NDUFC1 3 0.05 3.43 0.75 5.00
180 INT251319 Negative_regulation of Gene_expression of Fn1 4 0.07 1.82 0.74 5.00
181 INT145514 Localization of Nefh 5 0.32 2.23 0.72 5.00
182 INT265318 Negative_regulation of Gene_expression of Smad2 8 0.26 2.16 0.72 5.00
183 INT269896 Positive_regulation of Gene_expression of Smad2 9 0.40 2.15 0.69 5.00
184 INT327776 Negative_regulation of Gene_expression of Nqo1 2 0.02 2.39 0.69 5.00
185 INT196711 Localization of VMO1 2 0.60 0.61 0.61 5.00
186 INT196713 Gene_expression of VMO1 2 0.54 1.11 0.59 5.00
187 INT139780 Binding of AQP1 7 0.32 4.62 0.54 5.00
188 INT125821 Regulation of Positive_regulation of IGHE 6 0.40 5.38 0.53 5.00
189 INT327786 Negative_regulation of Gene_expression of AQP1 3 0.29 4.21 0.44 5.00
190 INT200606 Regulation of Gene_expression of Serpine1 4 0.38 2.07 0.35 5.00
191 INT101539 Regulation of EMG1 23 0.48 0.99 0.33 5.00
192 INT172783 Regulation of Localization of Serpine1 3 0.30 3.83 0.32 5.00
193 INT251949 Negative_regulation of Gene_expression of PRNP 6 0.43 4.16 0.3 5.00
194 INT167206 Positive_regulation of Positive_regulation of Casp8 4 0.49 2.11 0.26 5.00
195 INT232628 Gene_expression of Opa1 10 0.78 17.01 0.26 5.00
196 INT181133 Negative_regulation of Gene_expression of Cd8a 7 0.37 2.65 0.25 5.00
197 INT327787 Gene_expression of AQP9 4 0.28 2.5 0.23 5.00
198 INT183713 Localization of EMG1 5 0.58 0.37 0.19 5.00
199 INT183714 Gene_expression of EMG1 17 0.60 1.59 0.19 5.00
200 INT327780 Negative_regulation of Negative_regulation of AQP4 1 0.33 1.12 0.18 5.00
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