D:Autoimmune Hemolytic Anemia

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Disease Term
Synonyms Agglutinin Disease Cold, AGGLUTININ DISEASES COLD, Anemia Autoimmune Hemolytic, Anemia Hemolytic Idiopathic Acquired, Anemias Autoimmune Hemolytic, AUTOIMMUNE HEMOLYTIC ANEMIAS, COLD AGGLUTININ DISEASE, Cold Agglutinin Diseases, Disease Cold Agglutinin, Diseases Cold Agglutinin, Hemolytic Anemia Autoimmune
Documents 55
Hot Single Events 19
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Autoimmune Hemolytic Anemia. They are ordered first by their relevance to Autoimmune Hemolytic Anemia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT101942 Binding of CD40 and CD40LG 16 0.23 15.24 4.01 5.00
2 INT175329 Binding of ICAM1 and ITGAL 14 0.18 10.06 2.81 5.00
3 INT175330 IL6 Positive_regulation of Gene_expression of CYP19A1 1 0.01 0.97 0.32 5.00
4 INT352163 SNRPA Positive_regulation of Localization of IL10 1 0.06 0.87 0.23 5.00
5 INT175328 FASLG Positive_regulation of FAS 1 0.01 0.9 0.17 5.00
6 INT195195 IL4 Regulation of Gene_expression of IGHE 1 0.10 0.68 0.04 5.00
7 INT195199 Gene_expression of IL4 Positive_regulation of Gene_expression of IGHE 1 0.08 1.76 0 5.00
8 INT195198 Gene_expression of IL5 Positive_regulation of Gene_expression of IGHE 1 0.09 1.76 0 5.00
9 INT195197 Gene_expression of IL9 Positive_regulation of Gene_expression of IGHE 1 0.05 1.77 0 5.00
10 INT195196 IL13 Positive_regulation of Gene_expression of IGHE 1 0.06 1.79 0 5.00
11 INT195200 IL10 Positive_regulation of Gene_expression of IGHE 1 0.07 1.78 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Autoimmune Hemolytic Anemia. They are ordered first by their pain relevance and then by number of times they were reported in Autoimmune Hemolytic Anemia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 93.16
2 INT16364 Gene_expression of HLA-DRA 234 0.78 118.81 45.01 93.16
3 INT38671 Positive_regulation of KRT20 62 0.53 40.17 5.6 93.16
4 INT28249 Positive_regulation of HLA-DRA 25 0.70 13.63 3.25 93.16
5 INT102583 Gene_expression of Gdf15 26 0.77 15.33 4.52 91.84
6 INT102582 Positive_regulation of Gene_expression of Gdf15 11 0.69 7.66 1.68 91.84
7 INT102654 Positive_regulation of Pln 10 0.48 3.53 4.19 91.64
8 INT2120 Gene_expression of CD79A 159 0.78 111.69 17.16 90.24
9 INT50765 Positive_regulation of Fcer2a 23 0.68 10.22 2.92 87.84
10 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 87.40
11 INT29898 Negative_regulation of C6orf25 16 0.29 9.58 1.33 86.88
12 INT99298 Positive_regulation of ITGA3 6 0.06 2.94 1.54 86.00
13 INT105130 Positive_regulation of Arigg3 2 0.02 2.11 0.44 86.00
14 INT102585 Positive_regulation of Gdf15 19 0.69 14.78 3.21 85.32
15 INT47540 Binding of Cp 20 0.41 15.54 7.01 84.08
16 INT105131 Gene_expression of KRT122P 8 0.58 9.1 0.7 83.20
17 INT10721 Gene_expression of BDNF-AS 119 0.76 72.8 16.29 82.84
18 INT128160 Regulation of DDIT3 3 0.57 2.45 1.29 81.28
19 INT159446 Negative_regulation of Gdf15 5 0.58 3.36 1 80.44
20 INT310513 Gene_expression of Twsg1 1 0.17 3.97 0.28 78.60
21 INT12010 Gene_expression of Cp 38 0.65 20.55 7.84 78.60
22 INT318615 Negative_regulation of Gene_expression of Cp 2 0.03 1.08 0 78.60
23 INT63067 Localization of MYC 13 0.78 6.93 0.19 77.92
24 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 77.44
25 INT19428 Gene_expression of MTRF1 42 0.08 27.17 10.43 74.96
26 INT102655 Positive_regulation of Positive_regulation of Ighm 2 0.32 0.74 0.67 68.56
27 INT3795 Positive_regulation of Ighm 46 0.68 22.43 6.47 66.72
28 INT16445 Gene_expression of IL1A 60 0.78 44.46 19.19 66.56
29 INT58468 Negative_regulation of Gene_expression of IL1A 10 0.58 9.39 5.57 66.56
30 INT69310 Negative_regulation of IL1A 10 0.43 7.83 5.05 64.96
31 INT191112 Regulation of Cd68 3 0.12 3.27 1.49 64.16
32 INT219990 Regulation of Cd163 1 0.15 0.9 0.39 64.16
33 INT192918 Negative_regulation of HAMP 3 0.57 2.29 0.09 62.56
34 INT71634 Gene_expression of SLC6A3 45 0.78 13.48 15.23 61.84
35 INT119053 Positive_regulation of SLC6A3 15 0.65 2.51 4 61.84
36 INT756 Gene_expression of C3 138 0.75 100.6 19.2 60.80
37 INT25493 Gene_expression of TFPI 74 0.76 39.44 14.78 60.52
38 INT49975 Binding of SLC6A3 34 0.47 9.86 12.41 55.64
39 INT310527 Gene_expression of MDFIC 1 0.05 1.87 0.29 54.80
40 INT12264 Positive_regulation of Positive_regulation of IgG 6 0.30 2.01 1.09 51.72
41 INT164171 Gene_expression of Cd163 18 0.49 12.45 4.63 49.52
42 INT219992 Positive_regulation of Gene_expression of Cd163 1 0.27 0.95 0.41 49.52
43 INT29094 Binding of C3 39 0.37 12.65 2.27 47.12
44 INT8547 Gene_expression of MUC16 116 0.78 75.97 12.18 44.96
45 INT8545 Negative_regulation of MUC16 19 0.57 15.96 2.81 44.96
46 INT94881 Negative_regulation of Gene_expression of MUC16 4 0.42 2.51 0.61 44.96
47 INT13186 Positive_regulation of Il4 113 0.68 71.22 31.4 38.04
48 INT297528 Transcription of HAMP 3 0.69 3.64 0.5 37.76
49 INT310522 Regulation of Transcription of HAMP 1 0.60 1.36 0.05 37.76
50 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 36.16
51 INT219168 Positive_regulation of Localization of HMGB1 5 0.36 4 1.16 36.16
52 INT355765 Positive_regulation of Localization of Hmgb1 1 0.10 0.75 0.24 36.16
53 INT6852 Localization of TNF 883 0.81 705.95 270.84 35.60
54 INT6849 Localization of IL1B 229 0.81 112.56 69.63 35.60
55 INT184288 Localization of HMGB1 20 0.61 14.5 3.84 35.60
56 INT19189 Localization of IL1A 14 0.78 9.02 3.78 35.60
57 INT167657 Localization of Hmgb1 3 0.75 3.48 1.67 35.60
58 INT573 Negative_regulation of C3 60 0.59 41.37 7.78 32.40
59 INT156522 Gene_expression of NAPEPLD 11 0.75 4.25 2.87 31.28
60 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 26.20
61 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 25.00
62 INT54302 Positive_regulation of Gene_expression of Il4 126 0.68 86.18 30.75 25.00
63 INT46221 Positive_regulation of Gene_expression of IgG 46 0.53 33.66 7.7 25.00
64 INT39417 Gene_expression of Fcer2a 65 0.76 32.1 7.37 25.00
65 INT72890 Positive_regulation of Gene_expression of Fcer2a 12 0.17 6.81 2.25 25.00
66 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
67 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
68 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
69 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
70 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
71 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
72 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
73 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
74 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
75 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
76 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
77 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
78 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
79 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 5.00
80 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
81 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 5.00
82 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
83 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 5.00
84 INT9234 Negative_regulation of Gene_expression of IL6 171 0.59 101.61 53.15 5.00
85 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 5.00
86 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 5.00
87 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 5.00
88 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 5.00
89 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 5.00
90 INT12892 Negative_regulation of TIMP1 136 0.58 83.13 36.54 5.00
91 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 5.00
92 INT62830 Gene_expression of VCAM1 149 0.78 125.23 32.4 5.00
93 INT73498 Gene_expression of IL13 117 0.44 83.85 32.26 5.00
94 INT166203 Positive_regulation of Cia1 62 0.43 75.94 31.37 5.00
95 INT50230 Positive_regulation of Localization of IL6 105 0.70 69.21 29.52 5.00
96 INT69157 Gene_expression of IL5 127 0.77 102.58 26.81 5.00
97 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 5.00
98 INT4465 Gene_expression of CEL 116 0.77 98.35 23.58 5.00
99 INT74423 Localization of IL10 91 0.80 61.6 22.95 5.00
100 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52 5.00
101 INT71047 Gene_expression of CYP19A1 122 0.78 68.78 22.21 5.00
102 INT23257 Regulation of CRP 127 0.62 100.05 21.87 5.00
103 INT63340 Positive_regulation of Gene_expression of ICAM1 109 0.70 90.82 20.61 5.00
104 INT78901 Localization of CCL5 67 0.78 40.79 20.59 5.00
105 INT62042 Positive_regulation of Gene_expression of IL4 67 0.56 42.05 20.39 5.00
106 INT51055 Positive_regulation of TIMP1 103 0.69 50.07 19.86 5.00
107 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 5.00
108 INT9552 Positive_regulation of TNNI3 209 0.70 128.67 19.15 5.00
109 INT70614 Gene_expression of FAS 118 0.75 112.33 19.01 5.00
110 INT56301 Positive_regulation of IL4 68 0.56 54.51 18.65 5.00
111 INT80755 Gene_expression of CD40 88 0.75 53.68 17.86 5.00
112 INT45142 Gene_expression of DCPS 109 0.56 84.71 16.87 5.00
113 INT75929 Gene_expression of IL9 61 0.43 24.71 16.17 5.00
114 INT11340 Positive_regulation of SLC17A5 120 0.67 113.52 14.5 5.00
115 INT1758 Positive_regulation of Gene_expression of TIMP1 62 0.69 31.72 13.98 5.00
116 INT3796 Gene_expression of Ighm 130 0.77 69.61 13.78 5.00
117 INT173505 Localization of Hand2 63 0.57 45.32 13.66 5.00
118 INT4931 Localization of IFNG 53 0.78 33.25 13.65 5.00
119 INT11699 Binding of HLA-E 85 0.47 52.51 13.41 5.00
120 INT36263 Positive_regulation of CEL 53 0.69 34.88 12.87 5.00
121 INT89404 Regulation of Negative_regulation of TNF 30 0.45 24.47 12.71 5.00
122 INT79545 Positive_regulation of Gene_expression of ESR1 82 0.64 39.42 12.18 5.00
123 INT24816 Binding of CD40LG 68 0.47 45.48 11.56 5.00
124 INT65713 Localization of ICAM1 42 0.81 39.55 11.49 5.00
125 INT4240 Positive_regulation of CCL5 32 0.58 20.55 10.65 5.00
126 INT701 Localization of IGHE 87 0.80 40.5 10.62 5.00
127 INT58904 Localization of TH1L 40 0.68 27.11 10.52 5.00
128 INT35164 Negative_regulation of IGHE 96 0.58 76.3 9.74 5.00
129 INT80549 Binding of ICAM1 53 0.47 42.76 9.72 5.00
130 INT3988 Positive_regulation of Gene_expression of IGHE 98 0.68 91.46 9.61 5.00
131 INT132586 Negative_regulation of Hand2 40 0.30 26.58 9.28 5.00
132 INT1118 Gene_expression of C6orf25 73 0.77 47.24 9.1 5.00
133 INT27551 Gene_expression of SERPINH1 45 0.62 42.87 9.04 5.00
134 INT36449 Negative_regulation of G6PD 74 0.59 54.15 8.85 5.00
135 INT2241 Negative_regulation of CEL 56 0.58 29.32 8.83 5.00
136 INT20205 Binding of IgG 108 0.46 66.68 8.57 5.00
137 INT2512 Negative_regulation of Cp 27 0.51 10.15 8.37 5.00
138 INT119904 Regulation of CYP19A1 25 0.62 9.36 8.34 5.00
139 INT39170 Gene_expression of TSPO 76 0.78 24.11 8.05 5.00
140 INT15687 Regulation of ESR1 91 0.60 40.42 7.95 5.00
141 INT69160 Positive_regulation of IL5 41 0.65 36.04 7.75 5.00
142 INT153300 Negative_regulation of Gene_expression of CRP 48 0.58 39.97 7.58 5.00
143 INT95133 Gene_expression of FASLG 38 0.75 44.09 7.51 5.00
144 INT93003 Binding of CD40 28 0.47 20.25 7.13 5.00
145 INT1124 Negative_regulation of CD40LG 53 0.57 36.26 7 5.00
146 INT21579 Negative_regulation of Gene_expression of TIMP1 25 0.57 12.41 6.94 5.00
147 INT132822 Localization of IL13 26 0.67 22.85 6.66 5.00
148 INT83451 Positive_regulation of Gene_expression of CD40LG 26 0.60 22.81 6.25 5.00
149 INT128406 Gene_expression of Pax1 11 0.60 7.18 5.91 5.00
150 INT80033 Binding of FAS 37 0.48 41.19 5.67 5.00
151 INT23401 Gene_expression of HLA-DOA 91 0.30 38.21 5.52 5.00
152 INT65712 Positive_regulation of Localization of ICAM1 14 0.70 16.72 5.5 5.00
153 INT64888 Negative_regulation of HBM 52 0.16 34.33 5.45 5.00
154 INT69156 Localization of IL5 21 0.68 14.95 5.37 5.00
155 INT87322 Binding of ITGAL 23 0.47 15.73 4.68 5.00
156 INT133630 Negative_regulation of Gene_expression of ESR1 42 0.52 23.89 4.57 5.00
157 INT7083 Positive_regulation of HBM 35 0.66 20.96 4.3 5.00
158 INT50595 Positive_regulation of HRASLS 16 0.49 9.65 4.24 5.00
159 INT87027 Positive_regulation of Localization of IFNG 12 0.67 5.78 3.35 5.00
160 INT93915 Positive_regulation of Gene_expression of CD40 14 0.44 12.45 3.35 5.00
161 INT102741 Gene_expression of Atp9b 20 0.75 8.01 3.34 5.00
162 INT125237 Negative_regulation of Gene_expression of CD40LG 16 0.54 9.9 3.27 5.00
163 INT133809 Negative_regulation of Gene_expression of CYP19A1 9 0.43 7.67 2.99 5.00
164 INT78467 Negative_regulation of IL12A 18 0.38 11.29 2.98 5.00
165 INT85078 Positive_regulation of PCNA 36 0.49 17.06 2.81 5.00
166 INT67796 Negative_regulation of CTLA4 13 0.39 8.36 2.39 5.00
167 INT172078 Localization of Cd3e 22 0.37 9.88 2.27 5.00
168 INT71048 Transcription of CYP19A1 11 0.72 8.74 2.24 5.00
169 INT219180 Gene_expression of TLR7 13 0.68 9.51 2.21 5.00
170 INT3797 Positive_regulation of Gene_expression of Ighm 16 0.47 9.4 2.01 5.00
171 INT175361 Gene_expression of HPX 1 0.06 1.56 1.95 5.00
172 INT18007 Positive_regulation of C6orf25 23 0.66 14.98 1.95 5.00
173 INT219987 Positive_regulation of Positive_regulation of Cia1 3 0.05 4.41 1.81 5.00
174 INT177471 Localization of MTRF1 5 0.06 3.46 1.4 5.00
175 INT64952 Binding of HLA-DQA2 11 0.10 7.23 1.39 5.00
176 INT219159 Positive_regulation of TLR7 8 0.55 2.37 1.32 5.00
177 INT254308 Negative_regulation of TNFSF13B 10 0.42 5.12 1.25 5.00
178 INT132453 Binding of TF 31 0.36 12.98 1.22 5.00
179 INT74443 Positive_regulation of PML 11 0.53 12.52 1.21 5.00
180 INT205995 Gene_expression of SLC7A7 11 0.75 10.61 1.21 5.00
181 INT182343 Binding of Cd163 3 0.26 2.34 0.97 5.00
182 INT219993 Regulation of Gene_expression of Atp9b 1 0.44 2.3 0.96 5.00
183 INT23105 Gene_expression of MS4A1 5 0.75 5.17 0.95 5.00
184 INT204156 Gene_expression of HAMP 7 0.75 8.1 0.94 5.00
185 INT115964 Negative_regulation of ITGAL 7 0.34 3.76 0.86 5.00
186 INT170603 Negative_regulation of Gene_expression of CD40 5 0.32 2.18 0.78 5.00
187 INT175362 Binding of HPX 1 0.03 0.5 0.65 5.00
188 INT97130 Negative_regulation of CD40 5 0.35 1.96 0.63 5.00
189 INT234954 Negative_regulation of DSG1 22 0.42 19.5 0.62 5.00
190 INT310529 Positive_regulation of MDFIC 1 0.05 6.21 0.52 5.00
191 INT83641 Binding of CD63 4 0.19 1 0.45 5.00
192 INT161692 Regulation of NAPEPLD 2 0.17 0.9 0.45 5.00
193 INT219988 Regulation of Binding of Cd163 1 0.24 0.84 0.42 5.00
194 INT219991 Negative_regulation of Gene_expression of Atp9b 2 0.41 0.9 0.41 5.00
195 INT136180 Binding of MTOR 9 0.35 5.01 0.38 5.00
196 INT50530 Binding of MDFIC 2 0.17 1.88 0.38 5.00
197 INT306940 Positive_regulation of HAMP 3 0.49 5.06 0.36 5.00
198 INT352167 Negative_regulation of Positive_regulation of CEL 1 0.04 1.07 0.31 5.00
199 INT241859 Protein_catabolism of SLC40A1 2 0.02 1.22 0.31 5.00
200 INT310530 Positive_regulation of Gene_expression of HAMP 3 0.49 4.16 0.28 5.00
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