D:Autoimmune Lymphoproliferative Syndrome

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Disease Term
Synonyms Autoimmune Lymphoproliferative Syndrome Type 1 Autosomal Dominant, Autoimmune Lymphoproliferative Syndrome Type 2b, Autoimmune Lymphoproliferative Syndrome Type 2b Alps2b, Autoimmune Lymphoproliferative Syndromes, Canale Smith Syndrome, Caspase 8 Deficiencies, CASPASE 8 DEFICIENCY, Deficiencies Caspase 8, Deficiency Caspase 8, Lymphoproliferative Syndrome Autoimmune, Lymphoproliferative Syndromes Autoimmune
Documents 5
Hot Single Events 11
Hot Interactions 3

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Autoimmune Lymphoproliferative Syndrome. They are ordered first by their relevance to Autoimmune Lymphoproliferative Syndrome and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT91813 Binding of FAS and FASLG 4 0.23 9.89 0.99 92.40
2 INT193697 Apaf1 Positive_regulation of CASP9 1 0.02 1.84 0.12 91.92
3 INT193695 Il2 Positive_regulation of Ctla4 1 0.01 1.63 0.18 80.80
4 INT205120 Binding of CD4 and CD8A 3 0.15 2.83 0.72 5.00
5 INT330522 Binding of CD8A and TNFSF10 1 0.17 1.24 0.48 5.00
6 INT330515 TNFSF10 Regulation of Gene_expression of CD4 1 0.29 1.24 0.4 5.00
7 INT330518 TNFSF10 Regulation of CD4 1 0.29 1.24 0.4 5.00
8 INT330519 Binding of CD8A and DICER1 1 0.08 0.99 0.38 5.00
9 INT330516 Binding of CD8A and CCR6 1 0.07 0.99 0.38 5.00
10 INT330517 Binding of CD8A and HLA-DRB4 1 0.08 0.99 0.38 5.00
11 INT330521 Binding of CD4 and TNFSF10 1 0.20 0.73 0.24 5.00
12 INT330520 Positive_regulation of Binding of CD8A and TNFSF10 1 0.19 0.62 0.21 5.00
13 INT193693 Binding of Myd88 and Pain1 1 0.14 0.82 0.13 5.00
14 INT193691 Positive_regulation of Positive_regulation of Bcr 1 0.01 0.07 0.08 5.00
15 INT193692 IgG2a Positive_regulation of Bcr 1 0.02 0.07 0.08 5.00
16 INT193694 IgG2a Positive_regulation of Tlr9 1 0.05 0.07 0.08 5.00
17 INT193696 Binding of CD8A and Trav6-3 1 0.00 0.85 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Autoimmune Lymphoproliferative Syndrome. They are ordered first by their pain relevance and then by number of times they were reported in Autoimmune Lymphoproliferative Syndrome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT11803 Positive_regulation of Il2 62 0.70 31.44 18.93 99.46
2 INT80033 Binding of FAS 37 0.48 41.19 5.67 99.42
3 INT98132 Regulation of FAS 16 0.42 20.57 2.06 96.68
4 INT130775 Regulation of FASLG 4 0.30 5.8 1.82 96.68
5 INT95136 Binding of FASLG 6 0.33 8.01 2.41 92.40
6 INT116856 Gene_expression of TNFSF10 110 0.75 115.76 21.48 90.00
7 INT89966 Negative_regulation of Fas 26 0.58 24.83 3.5 89.24
8 INT133766 Negative_regulation of Fasl 11 0.56 11.28 2.27 89.24
9 INT112694 Negative_regulation of Positive_regulation of Fas 5 0.42 4.3 0.89 89.24
10 INT81629 Positive_regulation of Fas 58 0.70 59.63 12.94 88.72
11 INT99942 Positive_regulation of Fasl 37 0.68 32.61 6.92 88.72
12 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 79.20
13 INT157401 Gene_expression of Ctla4 21 0.65 15.43 3.2 79.12
14 INT111223 Positive_regulation of HMOX1 47 0.70 39.14 10.92 73.32
15 INT323752 Negative_regulation of FASLG 2 0.18 2.36 0.43 68.72
16 INT130926 Negative_regulation of TNFSF10 9 0.36 10.18 1.3 68.44
17 INT99780 Positive_regulation of Cxcl10 43 0.69 39.67 13.27 68.00
18 INT116528 Gene_expression of HMOX1 106 0.78 86.13 12.8 61.20
19 INT116527 Positive_regulation of Gene_expression of HMOX1 29 0.70 25.79 4.87 61.20
20 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44 48.24
21 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31 47.52
22 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 11.12
23 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
24 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
25 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 5.00
26 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43 5.00
27 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
28 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 5.00
29 INT11807 Gene_expression of Il2 266 0.78 112 64.97 5.00
30 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 5.00
31 INT63975 Positive_regulation of Il10 175 0.68 134.13 54.69 5.00
32 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53 5.00
33 INT19775 Localization of Il1 183 0.78 145.5 50.91 5.00
34 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 5.00
35 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
36 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 5.00
37 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 5.00
38 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 5.00
39 INT13186 Positive_regulation of Il4 113 0.68 71.22 31.4 5.00
40 INT21900 Gene_expression of Mthfd1 150 0.75 69.47 27.03 5.00
41 INT17331 Positive_regulation of JUN 132 0.69 60.4 27.03 5.00
42 INT19856 Gene_expression of CD8A 240 0.75 147.86 26.39 5.00
43 INT83797 Gene_expression of Bcl2l1 124 0.77 94.55 22.39 5.00
44 INT84732 Positive_regulation of Hand2 81 0.69 62.07 22 5.00
45 INT116978 Gene_expression of CCR6 53 0.78 56 17.73 5.00
46 INT9220 Gene_expression of Ighg1 125 0.77 85.74 15.92 5.00
47 INT5904 Localization of MPO 62 0.81 36.37 14.64 5.00
48 INT60197 Gene_expression of JUN 90 0.78 42.32 14.61 5.00
49 INT100938 Positive_regulation of Il13 47 0.69 42.11 14.36 5.00
50 INT31990 Positive_regulation of SOD1 124 0.69 67.79 12.52 5.00
51 INT112003 Localization of ROS1 94 0.73 66.32 12.16 5.00
52 INT81640 Positive_regulation of Gene_expression of Bcl2 106 0.69 84.58 11.63 5.00
53 INT20603 Positive_regulation of TNFRSF10B 40 0.67 32.61 11.44 5.00
54 INT15804 Gene_expression of ISG20 83 0.75 44.33 10.58 5.00
55 INT58449 Binding of Mthfd1 47 0.47 22.02 10.29 5.00
56 INT94784 Binding of ROS1 113 0.40 71.57 10.26 5.00
57 INT10019 Binding of CD8A 57 0.36 31.49 10.08 5.00
58 INT3988 Positive_regulation of Gene_expression of IGHE 98 0.68 91.46 9.61 5.00
59 INT97439 Positive_regulation of Il5 46 0.60 25.6 9.47 5.00
60 INT3846 Positive_regulation of GSR 60 0.50 35.16 9.37 5.00
61 INT70017 Positive_regulation of BCL2 87 0.67 66.62 8.68 5.00
62 INT61628 Negative_regulation of Gene_expression of IL4 31 0.55 20.96 8.18 5.00
63 INT193663 Binding of Pain1 9 0.36 8.84 8.04 5.00
64 INT160562 Localization of Cd4 49 0.71 27.58 6.78 5.00
65 INT23246 Gene_expression of HLA-DRB4 37 0.64 36.79 6.61 5.00
66 INT53196 Binding of Cd4 44 0.47 27.28 5.85 5.00
67 INT84704 Positive_regulation of Nqo1 18 0.70 18.64 5.65 5.00
68 INT150528 Positive_regulation of Gene_expression of TNFSF10 26 0.67 30.71 5.43 5.00
69 INT59891 Positive_regulation of GSTK1 46 0.67 17.66 5.33 5.00
70 INT16405 Regulation of CD8A 38 0.45 19.04 5.31 5.00
71 INT68244 Positive_regulation of Ighg1 60 0.61 48.86 5.01 5.00
72 INT149093 Positive_regulation of TNFSF10 31 0.49 34.61 4.56 5.00
73 INT188672 Positive_regulation of Tlr9 15 0.67 13.1 4.48 5.00
74 INT83794 Positive_regulation of Gene_expression of Bcl2l1 26 0.69 16.89 4.28 5.00
75 INT138698 Gene_expression of Txn1 15 0.77 11.71 4.24 5.00
76 INT57645 Gene_expression of GSTK1 54 0.62 21.05 4.2 5.00
77 INT26233 Binding of GSR 45 0.46 18.22 3.74 5.00
78 INT130295 Gene_expression of Abcg2 21 0.75 9.75 3.42 5.00
79 INT135773 Negative_regulation of Gene_expression of HMOX1 31 0.53 28.31 3.32 5.00
80 INT81453 Positive_regulation of Gene_expression of JUN 18 0.50 9.39 3.23 5.00
81 INT140555 Positive_regulation of Localization of ROS1 29 0.55 23.82 3.14 5.00
82 INT93936 Gene_expression of Pgp 10 0.59 3.43 3.04 5.00
83 INT9146 Gene_expression of FOLH1 26 0.75 10.76 2.85 5.00
84 INT190280 Gene_expression of DICER1 12 0.65 9.54 2.67 5.00
85 INT40315 Gene_expression of Abcc1 10 0.76 5.66 2.53 5.00
86 INT101641 Gene_expression of Mcl1 25 0.54 20.3 2.23 5.00
87 INT312696 Regulation of Gene_expression of CCR6 4 0.57 7.95 2.13 5.00
88 INT104931 Binding of TNFSF10 15 0.36 17.44 2.07 5.00
89 INT58691 Positive_regulation of Gene_expression of CD8A 26 0.50 15.19 1.97 5.00
90 INT125869 Regulation of Gene_expression of TNFSF10 5 0.38 8.77 1.9 5.00
91 INT188678 Binding of Tlr7 14 0.32 6.6 1.89 5.00
92 INT56925 Negative_regulation of TSC1 54 0.52 63.39 1.87 5.00
93 INT125865 Regulation of TNFSF10 12 0.44 15.75 1.81 5.00
94 INT61913 Binding of IgG2a 10 0.47 5.04 1.64 5.00
95 INT130774 Transcription of FASLG 5 0.67 2.02 1.22 5.00
96 INT330526 Positive_regulation of Gene_expression of DICER1 5 0.30 3.34 1.18 5.00
97 INT60542 Positive_regulation of Gene_expression of GSTK1 11 0.39 6.21 1.13 5.00
98 INT19628 Regulation of Xdh 6 0.45 1.9 1.07 5.00
99 INT130297 Positive_regulation of Gene_expression of Abcc1 3 0.56 1.06 0.97 5.00
100 INT135260 Negative_regulation of Pgp 4 0.42 1.13 0.95 5.00
101 INT143114 Positive_regulation of Gene_expression of HLA-DRB4 5 0.29 5.2 0.92 5.00
102 INT193666 Gene_expression of Gpr83 2 0.14 0.92 0.91 5.00
103 INT133323 Positive_regulation of Mod2 8 0.13 5.55 0.72 5.00
104 INT117416 Gene_expression of FAM20C 3 0.65 1.55 0.65 5.00
105 INT193665 Positive_regulation of Stat4 4 0.47 1.83 0.65 5.00
106 INT193672 Gene_expression of Prdx2 3 0.50 2.75 0.64 5.00
107 INT130387 Binding of CAT 4 0.36 2.39 0.55 5.00
108 INT158329 Positive_regulation of Gene_expression of Mcl1 9 0.32 7.53 0.54 5.00
109 INT186290 Binding of Pvrl1 8 0.11 4.82 0.46 5.00
110 INT330523 Regulation of Binding of TNFSF10 1 0.36 1.21 0.39 5.00
111 INT193674 Binding of Bcr 10 0.47 4.3 0.36 5.00
112 INT46843 Binding of Trf 10 0.47 3.45 0.35 5.00
113 INT330525 Positive_regulation of DICER1 2 0.17 1.34 0.34 5.00
114 INT67140 Regulation of Mod2 3 0.41 2.54 0.34 5.00
115 INT193669 Gene_expression of Pvrl1 13 0.22 6.4 0.33 5.00
116 INT330524 Negative_regulation of Gene_expression of HLA-DRB4 1 0.18 1.56 0.22 5.00
117 INT193667 Regulation of Localization of Cd4 2 0.43 1.01 0.21 5.00
118 INT187883 Gene_expression of Mod2 8 0.18 4.59 0.15 5.00
119 INT172476 Transcription of NFE2L2 7 0.69 2.47 0.11 5.00
120 INT193676 Positive_regulation of Gene_expression of Prdx2 2 0.06 1.31 0.09 5.00
121 INT250476 Negative_regulation of Transcription of FASLG 1 0.22 0.76 0.06 5.00
122 INT193687 Gene_expression of TIMM8A 2 0.49 1.27 0.04 5.00
123 INT193686 Positive_regulation of Positive_regulation of GLRX2 1 0.04 0.79 0.04 5.00
124 INT193678 Regulation of Transcription of NFE2L2 1 0.06 0.69 0.04 5.00
125 INT193677 Positive_regulation of Gene_expression of TIMM8A 1 0.03 0.91 0.04 5.00
126 INT193685 Positive_regulation of GLRX2 2 0.24 1.11 0.04 5.00
127 INT193680 Negative_regulation of GLRX2 1 0.03 0.8 0.04 5.00
128 INT193675 Regulation of Gene_expression of Mod2 1 0.05 0.89 0.03 5.00
129 INT193688 Positive_regulation of Gene_expression of GLRX2 1 0.04 0.7 0.03 5.00
130 INT193683 Gene_expression of GLRX2 1 0.05 0.7 0.03 5.00
131 INT193671 Gene_expression of Txnrd2 1 0.01 1.02 0 5.00
132 INT193679 Positive_regulation of Gene_expression of FAM20C 1 0.49 1.18 0 5.00
133 INT193670 Regulation of Csda 1 0.60 0.54 0 5.00
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