D:Autolysis

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Disease Term
Synonyms Autolyses
Documents 65
Hot Single Events 39
Hot Interactions 4

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Autolysis. They are ordered first by their relevance to Autolysis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT115512 KRT79 Negative_regulation of Positive_regulation of PRSS1 1 0.02 0.72 0.12 95.28
2 INT170885 Binding of PRSS1 and RHBDD2 1 0.01 0.4 0 92.72
3 INT115511 KRT79 Positive_regulation of PRSS2 1 0.02 0.71 0.12 91.88
4 INT115513 PRSS1 Positive_regulation of PRSS2 1 0.40 0.71 0.12 91.68
5 INT201512 Binding of PRSS1 and hcp 1 0.09 1.9 0.57 52.56
6 INT115507 Binding of PRSS1 and KRT79 Positive_regulation of Positive_regulation of PRSS2 1 0.03 0.46 0.09 51.96
7 INT115509 KRT79 Positive_regulation of Positive_regulation of PRSS2 1 0.02 0.46 0.09 51.96
8 INT115514 Binding of PRSS1 and KRT79 1 0.02 1.19 0.26 49.40
9 INT115510 Binding of PRSS1 and PRSS2 1 0.41 0.8 0.18 49.12
10 INT115508 Binding of PRSS2 and KRT79 1 0.02 0.39 0.09 48.32
11 INT246136 Binding of Ins1 and Capn10 1 0.14 0.86 0.03 47.32
12 INT246140 Ins1 Positive_regulation of Transcription of Capn10 1 0.19 0.76 0 35.08
13 INT246139 Ins1 Regulation of Transcription of Capn10 1 0.18 0.76 0 35.08
14 INT246138 Ins1 Positive_regulation of Capn10 1 0.19 0.75 0 35.08
15 INT272197 Binding of CAPN3 and DYSF 1 0.42 0.38 0 15.28
16 INT201490 Gene_expression of SPINK1 Negative_regulation of PRSS1 1 0.44 0.82 0.03 12.32
17 INT233387 Binding of SPINK1 and Il12b 1 0.04 0.33 0 5.52
18 INT346412 Binding of Tesc and Sv2a 1 0.02 0.6 0.59 5.00
19 INT346416 Binding of Tesc and Svs1 1 0.00 0.07 0.42 5.00
20 INT346409 Negative_regulation of Binding of mn and Tesc 1 0.00 0.29 0.22 5.00
21 INT346408 Binding of mn and Tesc 1 0.00 0.29 0.22 5.00
22 INT190381 IL1A Regulation of Transcription of DEFB4A 1 0.06 0.93 0.18 5.00
23 INT336751 Binding of Selp and Cd40 1 0.03 2.49 0.18 5.00
24 INT346414 Thy1 Positive_regulation of Binding of Tesc 1 0.00 0.16 0.15 5.00
25 INT233386 Binding of Il12a and Il12b 1 0.01 0.48 0.15 5.00
26 INT346411 Binding of Caprin1 and Mtus1 1 0.00 0.17 0.14 5.00
27 INT346410 Binding of Caprin1 and Tesc 1 0.00 0.17 0.14 5.00
28 INT233384 Il10 Negative_regulation of Il12a 1 0.01 0.54 0.11 5.00
29 INT190382 IL1A Regulation of Regulation of DEFB4A 1 0.06 0.57 0.1 5.00
30 INT209400 Binding of F13A1 and FGG 1 0.01 1.72 0.09 5.00
31 INT346415 Binding of Mns1 and Sv2a 1 0.03 0.14 0.07 5.00
32 INT346418 Sv2a Positive_regulation of Binding of Tesc 1 0.02 0.1 0.04 5.00
33 INT346407 Negative_regulation of Binding of Tesc and Sv2a 1 0.02 0 0.03 5.00
34 INT336752 Sparc Regulation of Regulation of Ilk 1 0.30 0.71 0.03 5.00
35 INT354487 Binding of F9 and PLEK 1 0.52 0.14 0 5.00
36 INT323590 Binding of Aldh2 and Napa 1 0.01 0.16 0 5.00
37 INT323591 Negative_regulation of Binding of Aldh2 and Napa 1 0.02 0.17 0 5.00
38 INT354513 Binding of Pla2g2a and Tes 1 0.00 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Autolysis. They are ordered first by their pain relevance and then by number of times they were reported in Autolysis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT272206 Gene_expression of CAPN3 4 0.77 3.83 0.7 100.00
2 INT3327 Protein_catabolism of PRSS1 22 1.00 6.96 4.29 100.00
3 INT95361 Negative_regulation of Protein_catabolism of PRSS1 1 0.43 0.66 0.08 100.00
4 INT3333 Positive_regulation of Protein_catabolism of PRSS1 3 0.49 2.23 1.29 100.00
5 INT342958 Positive_regulation of Gene_expression of CAPN3 1 0.69 0.66 0.35 100.00
6 INT115518 Protein_catabolism of KRT79 1 0.05 0.71 0.11 100.00
7 INT342956 Positive_regulation of Negative_regulation of CAPN3 1 0.46 0.16 0.06 99.98
8 INT73558 Regulation of IK 23 0.23 12.02 8.73 99.90
9 INT346376 Localization of Tesc 1 0.03 1 0.22 99.80
10 INT314671 Regulation of Srpx2 1 0.38 0.1 0 99.76
11 INT342960 Regulation of CAPN3 1 0.45 0.39 0.18 99.74
12 INT272202 Negative_regulation of CAPN3 4 0.59 0.99 0.2 99.74
13 INT342957 Positive_regulation of CAPN3 1 0.43 0.18 0 99.56
14 INT342954 Positive_regulation of Positive_regulation of CAPN3 1 0.43 0.1 0 99.56
15 INT1032 Regulation of Ca2 202 0.52 54.91 53.03 99.40
16 INT19799 Binding of Ca2 71 0.48 13.69 12.92 99.40
17 INT342959 Protein_catabolism of CAPN3 1 0.87 0.41 0.16 99.24
18 INT342961 Negative_regulation of Gene_expression of CAPN3 1 0.43 0.1 0 99.20
19 INT170090 Gene_expression of ICT1 6 0.07 3.96 0.37 99.08
20 INT235196 Protein_catabolism of VIM 5 0.62 2.68 0.17 98.96
21 INT12243 Positive_regulation of PRSS1 91 0.70 52.87 19.48 98.90
22 INT36554 Gene_expression of PRSS1 70 0.78 50.25 15.33 98.40
23 INT70608 Positive_regulation of Protein_catabolism of Nefm 1 0.18 0.43 0 98.28
24 INT70607 Protein_catabolism of Nefm 1 0.26 0.43 0 98.28
25 INT71497 Binding of Hspa1b 3 0.08 1.43 0.58 98.00
26 INT70609 Protein_catabolism of Cast 1 0.89 0.34 0.07 96.80
27 INT80549 Binding of ICAM1 53 0.47 42.76 9.72 96.08
28 INT46548 Negative_regulation of Acer3 1 0.06 0.5 0.08 94.32
29 INT46546 Binding of Cdc34 1 0.33 0.49 0.08 92.12
30 INT148702 Positive_regulation of UPF1 29 0.31 12.9 1.91 92.08
31 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 92.08
32 INT133172 Gene_expression of Il12b 98 0.75 52.16 10.68 91.00
33 INT12240 Negative_regulation of PRSS1 46 0.57 29.5 10.77 90.32
34 INT1429 Gene_expression of PDYN 308 0.78 61.33 175.65 89.68
35 INT12241 Negative_regulation of Positive_regulation of PRSS1 6 0.43 5.39 3.22 89.20
36 INT36835 Regulation of Ctsa 5 0.27 3.85 2.87 89.20
37 INT346369 Gene_expression of Tesc 1 0.03 1.37 0.18 82.40
38 INT115515 Positive_regulation of PRSS2 5 0.69 5.76 1.13 82.08
39 INT21078 Positive_regulation of Pxk 9 0.70 0.78 2.04 80.36
40 INT34138 Positive_regulation of Atp2a3 1 0.14 0.24 0.11 79.20
41 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 79.12
42 INT115517 Binding of PRSS2 1 0.48 1.08 0.18 78.72
43 INT46547 Positive_regulation of Cdc34 1 0.48 0.53 0.1 78.24
44 INT201509 Regulation of Protein_catabolism of PRSS1 1 0.61 1.2 0.14 76.80
45 INT346401 Positive_regulation of Localization of Rce1 1 0.01 0.61 0.03 76.48
46 INT246079 Localization of Rce1 3 0.05 0.8 0.13 75.96
47 INT34140 Negative_regulation of Vcp 2 0.10 0.23 1.32 75.80
48 INT6979 Positive_regulation of CA2 206 0.67 50.79 44.97 75.08
49 INT52264 Gene_expression of IK 180 0.77 90.87 51.87 72.56
50 INT342955 Protein_catabolism of SPTBN1 1 0.02 0.37 0.18 72.52
51 INT35864 Regulation of PRSS1 19 0.61 8.14 3.63 72.08
52 INT1396 Binding of Penk 355 0.48 22.79 269.65 70.52
53 INT34139 Binding of Nrd1 2 0.28 0.4 1.4 70.52
54 INT20631 Positive_regulation of CHKB 166 0.69 109.86 17.92 65.84
55 INT4342 Localization of ALPP 27 0.69 15.19 5.32 65.52
56 INT73223 Gene_expression of UPF1 78 0.41 31.44 9.94 64.88
57 INT170886 Gene_expression of AIRE 2 0.49 4.63 0.19 64.52
58 INT45692 Positive_regulation of Gene_expression of PRSS1 8 0.49 4.07 1.73 64.24
59 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 63.68
60 INT1033 Positive_regulation of Ca2 507 0.68 131.76 147.64 62.40
61 INT48222 Positive_regulation of Localization of IL8 123 0.59 78.04 37.2 62.12
62 INT68373 Negative_regulation of FLNA 59 0.57 60.46 9.55 61.96
63 INT233007 Negative_regulation of VIM 6 0.41 3.46 0.36 61.96
64 INT12339 Localization of IL8 437 0.81 251.87 117.39 61.84
65 INT137675 Binding of Srpx2 5 0.37 0.6 1.01 60.60
66 INT246120 Gene_expression of Capn10 1 0.62 8.84 0.1 60.44
67 INT17246 Negative_regulation of POLG 16 0.56 9.69 0.79 59.80
68 INT158837 Binding of POLG 4 0.37 4.69 0.44 59.80
69 INT171998 Binding of DMD 58 0.47 38.13 3.35 58.72
70 INT272207 Binding of DYSF 1 0.36 0.56 0 58.72
71 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 57.20
72 INT18483 Protein_catabolism of Tyr 4 0.97 0.58 0.6 52.24
73 INT115516 Positive_regulation of Positive_regulation of PRSS2 1 0.69 0.92 0.18 51.96
74 INT59454 Regulation of Gene_expression of CSF2 22 0.52 19.67 2.69 51.52
75 INT133028 Gene_expression of TLR2 209 0.73 131.92 36.17 51.28
76 INT185398 Negative_regulation of Gene_expression of TLR2 34 0.55 27.21 4.73 51.28
77 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 50.00
78 INT246129 Binding of Capn10 1 0.34 1.69 0.03 49.92
79 INT24946 Binding of PRSS1 23 0.47 16.75 6.41 49.40
80 INT246132 Negative_regulation of Transcription of Capn10 1 0.41 1.51 0 40.20
81 INT246135 Negative_regulation of Capn10 1 0.30 0.76 0 40.20
82 INT246123 Transcription of Capn10 1 0.50 3.89 0 39.88
83 INT63340 Positive_regulation of Gene_expression of ICAM1 109 0.70 90.82 20.61 35.08
84 INT81733 Transcription of Ins1 9 0.50 6.27 1.41 35.08
85 INT123640 Binding of LGMD1H 2 0.01 0.87 0.06 34.88
86 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 34.72
87 INT78659 Gene_expression of Thim 17 0.28 14.34 4.4 34.08
88 INT246127 Regulation of Transcription of Capn10 1 0.19 0.75 0 31.00
89 INT246133 Regulation of Capn10 1 0.43 0.74 0 31.00
90 INT242903 Gene_expression of SPI1 5 0.13 9.68 0.63 30.80
91 INT38885 Regulation of ICT1 3 0.20 2.02 0.26 29.32
92 INT86584 Phosphorylation of S100A8 10 0.80 4.99 0.41 26.20
93 INT115519 Localization of PRSS2 1 0.80 0.56 0.17 25.00
94 INT82743 Gene_expression of SPINK1 48 0.78 44.28 8.77 20.44
95 INT143422 Negative_regulation of Gene_expression of SPINK1 2 0.39 2.5 0.22 20.44
96 INT37907 Positive_regulation of Capns1 9 0.41 3.55 4.1 20.08
97 INT133174 Positive_regulation of Gene_expression of Il12b 29 0.15 13.04 2.92 16.96
98 INT103977 Positive_regulation of Gene_expression of SPINK1 7 0.50 7.38 2.66 12.32
99 INT91815 Positive_regulation of Positive_regulation of PRSS1 6 0.49 3.79 0.75 11.16
100 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
101 INT97367 Gene_expression of Nav1 243 0.78 132.97 286.66 5.00
102 INT94450 Gene_expression of Nav1 359 0.78 131.85 275.46 5.00
103 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
104 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
105 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
106 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
107 INT24326 Gene_expression of Ngf 346 0.78 218.67 184.71 5.00
108 INT49441 Negative_regulation of Cpox 494 0.59 303.22 177.46 5.00
109 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 5.00
110 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
111 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
112 INT49439 Gene_expression of Cpox 508 0.73 326.97 130.17 5.00
113 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03 5.00
114 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 5.00
115 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
116 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
117 INT3537 Positive_regulation of Car2 413 0.56 103.51 94.35 5.00
118 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43 5.00
119 INT1472 Positive_regulation of Ins1 349 0.69 146.2 86.36 5.00
120 INT92434 Phosphorylation of Mapk1 287 0.82 91.65 83.46 5.00
121 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5 5.00
122 INT60691 Gene_expression of Il12a 331 0.78 208.03 75.96 5.00
123 INT3657 Gene_expression of Ins1 514 0.78 321.69 75.76 5.00
124 INT39565 Gene_expression of Ptger2 424 0.75 229.28 72.68 5.00
125 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 5.00
126 INT7134 Localization of KNG1 127 0.79 65.73 67.97 5.00
127 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 5.00
128 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42 5.00
129 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
130 INT1200 Negative_regulation of Ins1 274 0.58 155.17 56.14 5.00
131 INT53083 Gene_expression of Ptgs2 153 0.78 90.04 50.39 5.00
132 INT92437 Positive_regulation of Phosphorylation of Mapk1 113 0.70 32.19 40.29 5.00
133 INT116321 Regulation of Nav1 38 0.62 26.62 37.97 5.00
134 INT62827 Positive_regulation of ICAM1 184 0.70 180.95 36.28 5.00
135 INT90792 Localization of Il10 144 0.80 87.88 30.03 5.00
136 INT65597 Negative_regulation of Casp3 69 0.59 39.19 29.32 5.00
137 INT102429 Negative_regulation of Gene_expression of Nav1 19 0.59 20.09 28.09 5.00
138 INT83708 Negative_regulation of MAPK1 156 0.57 84.93 27.85 5.00
139 INT115909 Positive_regulation of Gene_expression of Nav1 25 0.70 16.58 27.63 5.00
140 INT47075 Positive_regulation of Ptger2 142 0.70 78.55 25.47 5.00
141 INT10835 Regulation of IL8 79 0.49 53.04 24.14 5.00
142 INT17962 Regulation of Car2 124 0.41 33.98 22.71 5.00
143 INT69322 Negative_regulation of MAPK14 70 0.54 42.92 22.71 5.00
144 INT8483 Positive_regulation of Positive_regulation of TNF 73 0.67 60.35 22.03 5.00
145 INT10536 Gene_expression of Trib3 67 0.66 27.08 21.58 5.00
146 INT60690 Positive_regulation of Gene_expression of Il12a 69 0.63 41.41 20.85 5.00
147 INT78901 Localization of CCL5 67 0.78 40.79 20.59 5.00
148 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 5.00
149 INT23533 Gene_expression of CA2 110 0.75 30.81 19.4 5.00
150 INT84464 Gene_expression of DPP4 101 0.78 56.15 17.53 5.00
151 INT134298 Gene_expression of Ptges2 96 0.54 56.52 17.19 5.00
152 INT2120 Gene_expression of CD79A 159 0.78 111.69 17.16 5.00
153 INT170051 Positive_regulation of Gene_expression of Gopc 150 0.43 56.75 16.93 5.00
154 INT93948 Negative_regulation of Gene_expression of Il12a 48 0.55 27.77 16.87 5.00
155 INT19929 Negative_regulation of Positive_regulation of TNF 52 0.59 38.16 16.51 5.00
156 INT113384 Regulation of Gene_expression of Nav1 20 0.62 8.57 16.15 5.00
157 INT11685 Regulation of CSF2 99 0.59 58.82 15.9 5.00
158 INT1752 Negative_regulation of Ache 109 0.59 42.05 15.73 5.00
159 INT34590 Gene_expression of ALPP 199 0.75 89.85 15.1 5.00
160 INT109031 Positive_regulation of Eif2ak3 44 0.69 21.11 14.72 5.00
161 INT12135 Gene_expression of PLEK 62 0.75 34.13 12.47 5.00
162 INT11793 Negative_regulation of CA2 78 0.57 19.63 12.35 5.00
163 INT178338 Gene_expression of Tbx15 50 0.65 38.65 12.19 5.00
164 INT111948 Positive_regulation of Gria1 23 0.61 7.55 12.03 5.00
165 INT170601 Positive_regulation of Gene_expression of GOPC 122 0.43 42.79 11.68 5.00
166 INT148639 Gene_expression of Uchl1 30 0.59 16.76 11.54 5.00
167 INT23654 Binding of SPINK1 27 0.48 30.85 11.53 5.00
168 INT14204 Protein_catabolism of KNG1 41 0.96 20.94 11.47 5.00
169 INT56448 Regulation of ICAM1 52 0.60 55.1 10.96 5.00
170 INT150540 Binding of TLR2 50 0.45 35.86 10.43 5.00
171 INT69867 Gene_expression of Mip 36 0.75 24.54 10.38 5.00
172 INT78895 Regulation of CCL5 30 0.46 20.45 10.18 5.00
173 INT123142 Gene_expression of DEFB4A 54 0.76 36.14 10.02 5.00
174 INT14881 Gene_expression of Car3 49 0.73 14.89 9.94 5.00
175 INT106510 Gene_expression of Ptges 70 0.75 36.18 9.75 5.00
176 INT3366 Localization of PLEK 44 0.78 15.83 9.55 5.00
177 INT63338 Regulation of Gene_expression of ICAM1 42 0.62 28.26 9.06 5.00
178 INT9548 Gene_expression of CHKB 99 0.65 50.86 9.03 5.00
179 INT14301 Binding of CSF2 82 0.48 67.95 8.98 5.00
180 INT10969 Positive_regulation of PLEK 33 0.67 16.96 8.35 5.00
181 INT116605 Binding of Nos2 28 0.37 16.88 8.18 5.00
182 INT141656 Regulation of Eae1 22 0.39 32.62 8.12 5.00
183 INT2093 Gene_expression of GAST 50 0.78 32.32 7.98 5.00
184 INT154094 Negative_regulation of Eae1 25 0.18 30.42 7.89 5.00
185 INT19475 Positive_regulation of IL1A 20 0.67 17.99 7.57 5.00
186 INT64280 Positive_regulation of Ptger1 22 0.67 14.9 7.49 5.00
187 INT8684 Positive_regulation of ANGPTL5 45 0.69 36.29 7.47 5.00
188 INT22782 Localization of PRSS1 25 0.81 14.44 7.34 5.00
189 INT1123 Positive_regulation of CD79A 74 0.70 51.96 7.14 5.00
190 INT138802 Gene_expression of CFTR 36 0.70 18.8 7.02 5.00
191 INT195145 Positive_regulation of Gene_expression of CA2 25 0.37 7.2 6.59 5.00
192 INT9951 Gene_expression of ANGPTL5 45 0.53 37.2 6.44 5.00
193 INT15812 Localization of CALCB 10 0.30 8.77 6.36 5.00
194 INT150023 Positive_regulation of Il23a 25 0.38 18.33 6.32 5.00
195 INT63170 Positive_regulation of Selp 27 0.68 24.1 6.3 5.00
196 INT142904 Negative_regulation of Ptges2 14 0.47 9.49 6.15 5.00
197 INT75832 Positive_regulation of Positive_regulation of IL8 30 0.70 20.77 6.05 5.00
198 INT26585 Gene_expression of Vim 117 0.77 39.97 6 5.00
199 INT173974 Positive_regulation of Localization of Il10 25 0.68 16.81 5.87 5.00
200 INT60032 Negative_regulation of Pla2g2a 29 0.58 12.42 5.75 5.00
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