D:Autonomic Nervous System Disease

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Disease Term
Synonyms Ans Autonomic Nervous System Diseases, Ans Disease, ANS DISEASES, Autonomic Central Nervous System Diseases, AUTONOMIC DISEASE, AUTONOMIC DISEASES, AUTONOMIC DISORDER, Autonomic Disorders, AUTONOMIC DYSFUNCTION SEGMENTAL, Autonomic Dysfunctions Segmental, Autonomic Failure Pure
Documents 235
Hot Single Events 49
Hot Interactions 7

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Autonomic Nervous System Disease. They are ordered first by their relevance to Autonomic Nervous System Disease and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT118786 Binding of KIAA0101 and NANS 1 0.28 4.67 0.3 100.00
2 INT206764 Binding of AQP4 and Nqo1 8 0.05 13.45 2.84 97.36
3 INT108066 Binding of NTRK1 and Ngf 3 0.33 2.56 1.66 93.16
4 INT108065 Negative_regulation of Binding of Ngf and IgG-2a 1 0.01 2.38 1.2 93.16
5 INT108067 Negative_regulation of Binding of NTRK1 and Ngf 1 0.06 2.38 1.2 93.16
6 INT108064 Binding of Ngf and IgG-2a 1 0.01 2.36 1.19 93.16
7 INT18447 Binding of Ache and Chat 2 0.33 0.33 0.73 90.52
8 INT329120 Binding of KCNA1 and CNTNAP2 1 0.09 1.23 0.75 5.00
9 INT329119 Binding of CNTN2 and CNTNAP2 1 0.08 2.41 0.73 5.00
10 INT329116 Binding of LGI1 and CNTNAP2 1 0.38 1.3 0.44 5.00
11 INT189197 RASGRP1 Positive_regulation of JUN 1 0.07 1.26 0.43 5.00
12 INT329122 Binding of KCNA1 and LGI1 1 0.08 0.29 0.43 5.00
13 INT189200 Binding of CA2 and ITPR3 3 0.03 1.9 0.27 5.00
14 INT189199 JUN Positive_regulation of KRT16 1 0.31 0.58 0.22 5.00
15 INT189196 RASGRP1 Positive_regulation of SP1 1 0.05 0.63 0.21 5.00
16 INT329118 Binding of KCNA1 and CNTN2 1 0.02 0 0.14 5.00
17 INT332581 Binding of Nqo1 and MRI1 1 0.01 1.68 0.12 5.00
18 INT189195 Binding of C4A and C4B 1 0.14 2.45 0.09 5.00
19 INT325295 Binding of SGCA and C14orf166 1 0.04 0.54 0.08 5.00
20 INT329121 Binding of LGI1 and ADAM22 1 0.14 0.5 0.06 5.00
21 INT189202 Binding of C4B and HAS2 1 0.02 1.25 0.05 5.00
22 INT189198 Binding of C4A and SERPINF1 1 0.12 1.17 0.04 5.00
23 INT313273 Binding of GRIN1 and MAP2 1 0.16 0.79 0.04 5.00
24 INT351466 NMD3 Positive_regulation of Protein_catabolism of UPF1 1 0.00 0.54 0 5.00
25 INT313271 Binding of GRIN1 and GRIN2B 1 0.24 0.06 0 5.00
26 INT189203 CHGB Regulation of CA2 1 0.04 0.95 0 5.00
27 INT189201 CHGB Regulation of Localization of CA2 1 0.04 0.95 0 5.00
28 INT313272 Binding of DLG4 and GRIN1 1 0.09 0.06 0 5.00
29 INT351465 PRSS1 Regulation of Gene_expression of IKBKAP 1 0.00 0.65 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Autonomic Nervous System Disease. They are ordered first by their pain relevance and then by number of times they were reported in Autonomic Nervous System Disease. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT47390 Negative_regulation of Paf 18 0.58 14.81 9.66 100.00
2 INT27316 Negative_regulation of TPO 7 0.38 7.26 4.42 100.00
3 INT7620 Localization of TPO 4 0.26 5.35 0.88 100.00
4 INT70987 Binding of RAC1 14 0.37 12.14 2.13 99.96
5 INT1893 Localization of Gh 1041 0.79 340.23 256.58 99.84
6 INT5865 Positive_regulation of Localization of Gh 282 0.69 84.86 93.5 99.84
7 INT7619 Regulation of TPO 3 0.24 3.09 0.89 99.80
8 INT110 Regulation of Adrb3 33 0.60 8.09 13.84 99.80
9 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 99.74
10 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71 99.74
11 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18 99.64
12 INT11510 Negative_regulation of Positive_regulation of Gh 28 0.52 12.71 9.16 99.64
13 INT5513 Negative_regulation of Pomc 295 0.59 60.9 158.63 99.62
14 INT36263 Positive_regulation of CEL 53 0.69 34.88 12.87 99.40
15 INT1894 Negative_regulation of Localization of Gh 168 0.58 64.12 43.56 99.12
16 INT9292 Positive_regulation of SGCG 93 0.67 35.13 23.48 99.12
17 INT237655 Binding of Sfn 1 0.42 3.62 2.55 99.04
18 INT12951 Negative_regulation of Cat 126 0.57 64.39 20.61 98.16
19 INT10841 Positive_regulation of Gene_expression of Gh 101 0.59 45.39 16.96 97.88
20 INT164512 Regulation of MPZ 12 0.30 8.38 1.53 97.78
21 INT89425 Positive_regulation of HLA-DRB3 2 0.59 2.38 0.42 97.24
22 INT114330 Binding of MPZ 21 0.32 25.58 2.14 96.80
23 INT164511 Negative_regulation of Binding of MPZ 2 0.36 1.64 0.29 96.80
24 INT1218 Negative_regulation of Maob 24 0.59 9.76 9.39 96.76
25 INT53906 Positive_regulation of Negative_regulation of Gh 9 0.50 6.72 2.73 96.36
26 INT9246 Positive_regulation of Cat 113 0.70 52.73 18.04 96.04
27 INT1316 Positive_regulation of Acot1 129 0.60 18.86 56.13 96.04
28 INT1079 Positive_regulation of Ache 104 0.70 23.52 30.28 96.04
29 INT4851 Positive_regulation of Chat 53 0.70 9.21 15.11 96.04
30 INT683 Positive_regulation of AVP 173 0.70 74.55 46.41 95.40
31 INT149405 Binding of MAG 1 0.01 1.65 0.13 94.36
32 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26 93.56
33 INT6625 Negative_regulation of Pth 96 0.58 57.6 8.24 93.56
34 INT157959 Binding of AQP4 32 0.48 43.44 7.44 92.64
35 INT19078 Binding of Ngf 78 0.48 31.03 44.33 91.44
36 INT30022 Positive_regulation of Acot7 3 0.19 0.19 1.37 91.44
37 INT41789 Negative_regulation of Moxd2 6 0.57 4.03 2.49 91.28
38 INT49 Negative_regulation of Ren 129 0.59 37.48 35.62 90.76
39 INT1080 Negative_regulation of Ache 343 0.59 108.51 72.4 90.08
40 INT28325 Negative_regulation of Tst 13 0.51 12.41 3.16 89.44
41 INT1166 Negative_regulation of Dbh 56 0.59 12.54 28.26 87.60
42 INT141233 Negative_regulation of Positive_regulation of Dbh 2 0.42 0.39 1.33 87.60
43 INT16150 Positive_regulation of NKG7 10 0.69 10.26 1.73 86.84
44 INT86646 Positive_regulation of SCN10A 71 0.69 50.61 13.24 86.40
45 INT14849 Binding of IgG-2a 12 0.39 5.96 6.06 86.40
46 INT3382 Positive_regulation of Dbh 33 0.70 11.64 21.67 85.96
47 INT203636 Positive_regulation of CD2AP 4 0.13 1.27 0.28 85.04
48 INT9764 Gene_expression of Adrb3 10 0.62 4.14 2.33 82.48
49 INT682 Negative_regulation of AVP 97 0.59 50.67 23.91 80.56
50 INT250282 Negative_regulation of AQP4 32 0.54 32.96 9.07 79.92
51 INT140411 Gene_expression of Nqo1 45 0.60 62.35 8.7 79.92
52 INT84703 Negative_regulation of Nqo1 8 0.38 7.1 4.05 79.92
53 INT19396 Regulation of Rac1 66 0.53 37.41 30.01 79.88
54 INT140170 Binding of Nqo1 24 0.38 36.16 6.79 76.92
55 INT157772 Gene_expression of ASF1B 3 0.07 2.78 0.49 72.12
56 INT654 Localization of REN 250 0.81 75.12 47.86 72.08
57 INT1372 Regulation of Localization of REN 50 0.62 5.76 9.81 72.08
58 INT3738 Regulation of Epo 25 0.61 13.73 6.18 70.44
59 INT149404 Positive_regulation of MAG 1 0.01 1.65 0.12 67.76
60 INT180497 Binding of MRI1 45 0.42 28.35 14.77 65.72
61 INT65697 Positive_regulation of GRIN3B 23 0.69 12.52 13.78 65.24
62 INT136397 Gene_expression of bt2 1 0.08 1.29 0.14 64.24
63 INT254614 Positive_regulation of Csf1r 1 0.26 1.31 0.65 63.12
64 INT14501 Gene_expression of CST3 28 0.75 25.77 5.16 61.52
65 INT143551 Binding of KCNA1 13 0.46 8.81 2.81 60.80
66 INT203637 Binding of CD2AP 1 0.04 0.57 0.03 60.80
67 INT11377 Positive_regulation of Ngf 331 0.70 206.5 238 55.84
68 INT189249 Localization of BGN 2 0.08 2.14 0.8 55.12
69 INT17546 Negative_regulation of Ngf 135 0.59 60.28 77.19 53.72
70 INT10847 Gene_expression of LAMC2 39 0.75 27 12.09 53.64
71 INT67912 Gene_expression of GRIN1 75 0.77 28.99 29.28 53.48
72 INT351510 Regulation of Regulation of IKBKAP 1 0.27 0.45 0 51.60
73 INT351501 Regulation of IKBKAP 18 0.62 12.5 0 51.60
74 INT140413 Gene_expression of AQP4 113 0.78 139.25 25.53 48.24
75 INT110638 Negative_regulation of COMT 43 0.59 21.03 21.05 47.88
76 INT5561 Negative_regulation of GRIN2D 10 0.50 2.46 4.88 46.88
77 INT47127 Gene_expression of BGN 11 0.75 17.09 6.25 44.56
78 INT31874 Negative_regulation of Gene_expression of Abat 31 0.42 12.22 20.31 44.32
79 INT9987 Gene_expression of Abat 296 0.78 95.46 226.34 43.76
80 INT142491 Positive_regulation of Positive_regulation of SCN10A 6 0.61 3.48 0.35 41.04
81 INT132335 Gene_expression of KCNA1 36 0.77 18.31 13.36 40.44
82 INT329151 Positive_regulation of Gene_expression of KCNA1 1 0.11 1.18 0.24 40.44
83 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 40.24
84 INT2649 Regulation of Calca 433 0.62 146.05 330.95 40.20
85 INT98788 Negative_regulation of EPHB1 11 0.37 3.65 1.64 39.24
86 INT111263 Gene_expression of Gnb5 8 0.75 8.51 3 37.52
87 INT251746 Protein_catabolism of Ssr1 1 0.26 0.26 0 35.72
88 INT59466 Gene_expression of ISYNA1 204 0.77 112.57 35.48 35.36
89 INT73594 Positive_regulation of Gene_expression of ISYNA1 61 0.55 31.35 13.45 35.36
90 INT309249 Regulation of OGDHL 1 0.01 0.6 0.3 34.00
91 INT116763 Gene_expression of IKBKAP 63 0.78 54.53 0.79 33.84
92 INT116762 Positive_regulation of Gene_expression of IKBKAP 10 0.70 9.79 0.19 33.84
93 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 33.68
94 INT25 Positive_regulation of LAMC2 19 0.67 8.64 7.06 33.24
95 INT132613 Gene_expression of LGI1 2 0.71 5.9 4.15 32.24
96 INT329148 Gene_expression of CNTNAP2 17 0.76 6 2.95 32.24
97 INT329150 Regulation of Gene_expression of LGI1 1 0.41 0.87 0.11 32.24
98 INT329160 Regulation of Gene_expression of CNTNAP2 1 0.44 0.87 0.11 32.24
99 INT309251 Gene_expression of OGDHL 1 0.01 0.64 0.29 32.16
100 INT8959 Binding of Gnb5 17 0.40 31.38 5.1 29.92
101 INT132334 Negative_regulation of Gene_expression of KCNA1 4 0.43 1.52 1.14 29.72
102 INT172458 Regulation of Gopc 155 0.53 62.57 24.86 28.64
103 INT254616 Regulation of Pdia6 1 0.25 0.69 0.07 28.64
104 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 27.16
105 INT70356 Gene_expression of GRIN2D 10 0.74 2.11 4.7 25.00
106 INT78749 Gene_expression of SCN10A 25 0.75 9.23 16.5 21.76
107 INT251741 Regulation of Gene_expression of SCN10A 1 0.45 1.08 0.06 21.76
108 INT251742 Regulation of Positive_regulation of SCN10A 1 0.27 1.37 0.06 21.76
109 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 20.92
110 INT6128 Positive_regulation of Localization of POMC 256 0.70 68.77 121.64 20.92
111 INT443 Localization of POMC 1020 0.81 284.52 443.17 19.60
112 INT143612 Positive_regulation of AIC 13 0.70 2.95 6.15 17.24
113 INT351498 Negative_regulation of Binding of IKBKAP 1 0.37 0.51 0 12.88
114 INT248374 Binding of IKBKAP 10 0.42 10.45 1.9 11.04
115 INT351488 Regulation of Binding of IKBKAP 1 0.45 1.06 0 11.04
116 INT5653 Positive_regulation of ELANE 136 0.70 72.78 27.94 7.52
117 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 5.00
118 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81 5.00
119 INT46460 Gene_expression of NAV1 288 0.78 135.51 305.75 5.00
120 INT2211 Negative_regulation of Abat 267 0.59 66.51 200.98 5.00
121 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
122 INT2910 Regulation of Abat 169 0.62 36.95 153.53 5.00
123 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 5.00
124 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
125 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
126 INT214 Localization of AVP 370 0.81 208.51 91.09 5.00
127 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 5.00
128 INT8347 Gene_expression of SST 181 0.78 104.59 65.45 5.00
129 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
130 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
131 INT1536 Negative_regulation of NA 244 0.55 52.67 59.79 5.00
132 INT6623 Gene_expression of NA 231 0.78 45.78 59.36 5.00
133 INT129303 Positive_regulation of NAV1 54 0.70 36.92 57.45 5.00
134 INT74389 Gene_expression of Gdnf 131 0.78 58.52 57.06 5.00
135 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
136 INT9556 Negative_regulation of NAV1 47 0.59 28.49 49.33 5.00
137 INT42980 Gene_expression of GAD1 139 0.69 94.77 45.11 5.00
138 INT27493 Negative_regulation of Casp3 114 0.56 56.89 44.63 5.00
139 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
140 INT122953 Gene_expression of COMT 65 0.77 25.84 40.49 5.00
141 INT685 Regulation of AVP 124 0.62 34.9 39.91 5.00
142 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 5.00
143 INT1931 Positive_regulation of Gene_expression of POMC 116 0.70 37.26 38.67 5.00
144 INT3679 Gene_expression of AVP 171 0.78 72.9 35.23 5.00
145 INT47710 Negative_regulation of GRIN1 71 0.57 25.57 34.24 5.00
146 INT5489 Localization of CA2 172 0.80 39.46 33.56 5.00
147 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 5.00
148 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
149 INT1196 Positive_regulation of Positive_regulation of POMC 51 0.70 15.99 28.58 5.00
150 INT6624 Gene_expression of Pth 135 0.76 110.27 27.54 5.00
151 INT116226 Regulation of NAV1 20 0.51 14.32 25.61 5.00
152 INT61664 Regulation of GRIN1 38 0.60 16.45 25.35 5.00
153 INT47459 Gene_expression of Rac1 101 0.68 45.27 24.33 5.00
154 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73 5.00
155 INT8580 Gene_expression of ELANE 132 0.75 62.98 21.79 5.00
156 INT6127 Regulation of Localization of AVP 60 0.62 15.12 20.84 5.00
157 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
158 INT11243 Localization of NPY 33 0.78 11.18 19.24 5.00
159 INT756 Gene_expression of C3 138 0.75 100.6 19.2 5.00
160 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9 5.00
161 INT6782 Gene_expression of SCN5A 156 0.78 33.13 17.88 5.00
162 INT6791 Binding of NA 55 0.46 5.36 17.59 5.00
163 INT7580 Positive_regulation of Mbp 54 0.70 23.37 17.14 5.00
164 INT213 Negative_regulation of Localization of AVP 46 0.59 19.78 16.79 5.00
165 INT653 Negative_regulation of Localization of REN 67 0.59 20.33 16.7 5.00
166 INT6129 Positive_regulation of Localization of AVP 63 0.70 30.44 16.64 5.00
167 INT1020 Negative_regulation of BCHE 109 0.59 44.86 16.4 5.00
168 INT10721 Gene_expression of BDNF-AS 119 0.76 72.8 16.29 5.00
169 INT114507 Negative_regulation of Gene_expression of NAV1 17 0.43 7.24 15.93 5.00
170 INT11685 Regulation of CSF2 99 0.59 58.82 15.9 5.00
171 INT85639 Positive_regulation of Tg(CAG-EGFP)D4Nagy 95 0.43 24.83 15.69 5.00
172 INT71634 Gene_expression of SLC6A3 45 0.78 13.48 15.23 5.00
173 INT18513 Binding of GRIN1 32 0.47 9.44 15.08 5.00
174 INT22301 Positive_regulation of Gene_expression of CSF2 66 0.63 59.49 14.24 5.00
175 INT69435 Negative_regulation of ROS1 74 0.51 50.38 13.71 5.00
176 INT655 Positive_regulation of Localization of REN 86 0.70 32.41 13.56 5.00
177 INT7465 Negative_regulation of Mbp 53 0.58 19.12 13.27 5.00
178 INT49975 Binding of SLC6A3 34 0.47 9.86 12.41 5.00
179 INT8548 Gene_expression of HP 86 0.77 47.62 11.94 5.00
180 INT39587 Gene_expression of CP 42 0.65 31.48 11.87 5.00
181 INT661 Gene_expression of REN 100 0.78 48.21 11.36 5.00
182 INT15238 Positive_regulation of NPY 24 0.67 11.86 11.26 5.00
183 INT16449 Binding of IGHG3 67 0.48 39.55 10.59 5.00
184 INT104441 Binding of NOVA2 72 0.42 16.41 10.51 5.00
185 INT110178 Phosphorylation of MAPK14 40 0.68 19.38 10.37 5.00
186 INT73223 Gene_expression of UPF1 78 0.41 31.44 9.94 5.00
187 INT6065 Localization of GRIN1 15 0.74 3.15 9.81 5.00
188 INT11047 Positive_regulation of Positive_regulation of IL6 45 0.66 28.7 9.37 5.00
189 INT95342 Gene_expression of GRIN2B 21 0.75 4.99 9.32 5.00
190 INT44550 Positive_regulation of Gene_expression of AVP 38 0.70 22.27 8.62 5.00
191 INT86639 Gene_expression of KRT16 19 0.68 12.44 7.79 5.00
192 INT32579 Binding of C4B 14 0.36 14.99 7.79 5.00
193 INT32580 Gene_expression of C4B 24 0.75 17.95 7.75 5.00
194 INT189230 Gene_expression of GSN 12 0.75 25.04 7.6 5.00
195 INT6906 Negative_regulation of SCN5A 64 0.43 20.64 7.3 5.00
196 INT15872 Positive_regulation of EPO 74 0.70 45.35 6.67 5.00
197 INT49212 Negative_regulation of GAD1 23 0.59 22.15 6.54 5.00
198 INT7464 Regulation of Mbp 25 0.62 6.62 6.43 5.00
199 INT57232 Binding of Casp3 22 0.36 9.42 6.2 5.00
200 INT14486 Localization of Mbp 23 0.74 11.24 6.14 5.00
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