D:Autosomal Dominant Optic Atrophy

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Disease Term
Synonyms Dominant Optic Atrophies, Dominant Optic Atrophy, Optic Atrophies Dominant, OPTIC ATROPHY DOMINANT, OPTIC ATROPHY HEREDITARY AUTOSOMAL DOMINANT, OPTIC ATROPHY KJER TYPE, Optic Atrophy Type 1
Documents 8
Hot Single Events 6
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Autosomal Dominant Optic Atrophy. They are ordered first by their relevance to Autosomal Dominant Optic Atrophy and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT314868 Binding of Ltbp2 and Ltbp3 1 0.29 0.54 0 56.72
2 INT314870 Binding of Ltbp3 and Tgfb3 1 0.24 0.52 0 46.64
3 INT314862 Binding of Ltbp3 and Tgfb2 1 0.24 0.52 0 45.76
4 INT314865 Binding of Ltbp3 and Tgfb1 1 0.24 0.51 0 45.20
5 INT314856 Binding of Cdc7 and Cdkn2a 1 0.28 1.34 0.14 5.00
6 INT302676 Binding of OPA1 and MFN2 1 0.46 1.12 0.14 5.00
7 INT314867 Binding of Cdc7 and Cdkn2b 1 0.25 1.16 0.14 5.00
8 INT314852 Binding of Cdkn2a and Tgfbr3 1 0.28 1.15 0.14 5.00
9 INT314859 Binding of Cdkn2b and Tgfbr3 1 0.33 1.16 0.14 5.00
10 INT329015 Binding of APCS and SRGN 1 0.08 1.14 0.04 5.00
11 INT314869 Binding of Gdf11 and Tgfbr3 1 0.29 0.14 0 5.00
12 INT314863 Binding of Neurod1 and Atoh7 1 0.18 0.27 0 5.00
13 INT314850 Shh Regulation of Atoh7 1 0.45 0.22 0 5.00
14 INT314858 Binding of Gdf11 and Ltbp3 1 0.39 0.31 0 5.00
15 INT314854 Gdf11 Regulation of Atoh7 1 0.51 0.21 0 5.00
16 INT314871 Binding of Tgfbr3 and Atoh7 1 0.33 0.09 0 5.00
17 INT314855 Binding of Gdf11 and Atoh7 1 0.40 0.14 0 5.00
18 INT314851 Positive_regulation of Binding of Neurod1 and Atoh7 1 0.23 0.27 0 5.00
19 INT314866 Binding of Six1 and Sall1 1 0.39 0.76 0 5.00
20 INT302675 Binding of OPA1 and PLAA 1 0.15 0.73 0 5.00
21 INT314861 Gdf11 Regulation of Gene_expression of Atoh7 1 0.20 0.26 0 5.00
22 INT314857 Atoh7 Regulation of Pou4f2 1 0.21 0.21 0 5.00
23 INT314860 Gene_expression of Atoh7 Positive_regulation of 1190002H23Rik 1 0.02 0.27 0 5.00
24 INT314864 Binding of Neurod1 and Positive_regulation of Gene_expression of Atoh7 1 0.25 0.27 0 5.00
25 INT314853 Binding of Cdc7 and Tgfbr3 1 0.24 0.09 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Autosomal Dominant Optic Atrophy. They are ordered first by their pain relevance and then by number of times they were reported in Autosomal Dominant Optic Atrophy. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT314837 Binding of Chek2 1 0.32 2.75 0 96.08
2 INT15367 Gene_expression of OPA1 35 0.67 24.9 5.45 95.84
3 INT4228 Gene_expression of CAT 50 0.75 20.62 7.18 86.80
4 INT22132 Positive_regulation of CAT 41 0.67 18.64 10.67 86.80
5 INT14510 Gene_expression of SOD1 208 0.76 88.56 12.4 85.76
6 INT31990 Positive_regulation of SOD1 124 0.69 67.79 12.52 85.76
7 INT314829 Gene_expression of Dclk1 1 0.67 0.66 0 65.28
8 INT232634 Localization of Opa1 2 0.75 1.11 0 61.56
9 INT302684 Negative_regulation of RRM2B 1 0.17 0.73 0.08 50.56
10 INT302686 Negative_regulation of Localization of RRM2B 1 0.38 0.73 0.08 50.56
11 INT302694 Localization of RRM2B 1 0.66 0.73 0.07 50.56
12 INT302698 Negative_regulation of MPV17 1 0.16 0.67 0.08 49.76
13 INT302690 Negative_regulation of Localization of MPV17 1 0.37 0.67 0.08 49.76
14 INT302685 Localization of MPV17 1 0.65 0.67 0.07 49.76
15 INT302705 Localization of SUCLG1 1 0.65 0.66 0.07 49.20
16 INT302702 Negative_regulation of SUCLG1 1 0.16 0.66 0.07 49.20
17 INT302691 Negative_regulation of Localization of SUCLG1 1 0.37 0.66 0.07 49.20
18 INT74550 Negative_regulation of SUCLA2 5 0.41 3.6 1.24 48.56
19 INT52460 Localization of SUCLA2 5 0.67 2.5 0.86 48.56
20 INT155170 Negative_regulation of Localization of SUCLA2 2 0.38 1.26 0.28 48.56
21 INT302696 Negative_regulation of Localization of TK2 1 0.37 0.65 0.07 47.92
22 INT302700 Localization of TK2 1 0.65 0.65 0.07 47.92
23 INT302689 Negative_regulation of TK2 1 0.16 0.65 0.07 47.92
24 INT302697 Negative_regulation of DGUOK 1 0.38 0.65 0.07 47.52
25 INT302681 Negative_regulation of Localization of DGUOK 1 0.38 0.65 0.07 47.52
26 INT302680 Localization of DGUOK 1 0.66 0.65 0.07 47.52
27 INT224340 Localization of TYMP 3 0.62 2.86 0.3 46.96
28 INT302704 Negative_regulation of Localization of TYMP 1 0.35 0.64 0.07 46.96
29 INT211378 Negative_regulation of TYMP 2 0.56 1.45 0.07 46.96
30 INT314827 Binding of Tgfb3 1 0.36 0.51 0 46.64
31 INT17094 Negative_regulation of SLC25A4 3 0.41 3.82 1.52 46.48
32 INT19047 Localization of SLC25A4 5 0.73 2.73 0.57 46.48
33 INT302699 Negative_regulation of Localization of SLC25A4 1 0.38 1.01 0.11 46.48
34 INT251828 Negative_regulation of C10orf2 3 0.37 2.87 0.41 45.76
35 INT302693 Localization of C10orf2 1 0.59 1 0.11 45.76
36 INT302695 Negative_regulation of Localization of C10orf2 1 0.33 1 0.11 45.76
37 INT314821 Binding of Tgfb2 1 0.36 0.51 0 45.76
38 INT284528 Negative_regulation of POLG2 2 0.17 2.19 0.33 45.28
39 INT302682 Localization of POLG2 1 0.67 1 0.11 45.28
40 INT302706 Negative_regulation of Localization of POLG2 1 0.38 1 0.11 45.28
41 INT48198 Binding of Tgfb1 29 0.47 19.59 2.46 45.20
42 INT17246 Negative_regulation of POLG 16 0.56 9.69 0.79 44.72
43 INT302679 Negative_regulation of Localization of POLG 1 0.39 0.99 0.11 44.72
44 INT302692 Localization of POLG 1 0.69 0.99 0.1 44.72
45 INT314833 Binding of Ltbp3 1 0.32 0.82 0 44.48
46 INT314844 Positive_regulation of Ltbp3 1 0.39 0.5 0 40.24
47 INT314838 Binding of Scyl1 1 0.30 0.45 0 34.48
48 INT242208 Regulation of Gene_expression of SRGN 7 0.29 3.15 0.52 30.24
49 INT329016 Regulation of Gene_expression of GON4L 1 0.06 1.12 0.05 30.24
50 INT329020 Regulation of GON4L 1 0.06 1.12 0.05 30.24
51 INT105571 Gene_expression of SRGN 33 0.58 14.68 1.19 28.16
52 INT227780 Gene_expression of GON4L 2 0.13 2.72 0.05 27.84
53 INT314835 Binding of Atoh7 1 0.44 0.05 0 21.96
54 INT314828 Transcription of Six6 1 0.58 1.23 0 5.76
55 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
56 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18 5.00
57 INT22454 Regulation of Crp 213 0.62 160.67 49.24 5.00
58 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 5.00
59 INT2774 Binding of Crp 241 0.48 195.89 44.39 5.00
60 INT37296 Binding of Esr1 117 0.43 62.51 27.33 5.00
61 INT17041 Gene_expression of PER1 24 0.66 5.31 7.12 5.00
62 INT33854 Localization of OPA1 19 0.65 10.55 5.04 5.00
63 INT34870 Positive_regulation of OPA1 18 0.59 10.66 5 5.00
64 INT32933 Gene_expression of GNAS 57 0.32 10.58 4.03 5.00
65 INT24883 Regulation of OPA1 14 0.45 9.73 3.44 5.00
66 INT19393 Gene_expression of Gfm1 31 0.51 18.9 3.2 5.00
67 INT5913 Binding of OPA1 12 0.41 9.33 2.92 5.00
68 INT39856 Binding of Neurod1 8 0.47 1.44 2.88 5.00
69 INT168188 Gene_expression of PLXNA2 13 0.58 9 2.73 5.00
70 INT57970 Positive_regulation of Rb1 17 0.67 7.03 2.36 5.00
71 INT18853 Negative_regulation of APCS 13 0.57 4.51 2.3 5.00
72 INT169907 Gene_expression of Rb1 25 0.60 21.95 1.32 5.00
73 INT237247 Regulation of Mri1 6 0.27 4.64 1.2 5.00
74 INT159409 Gene_expression of PLAA 2 0.54 6.14 0.89 5.00
75 INT169911 Phosphorylation of Rb1 35 0.73 18.58 0.79 5.00
76 INT276227 Gene_expression of UBL4A 9 0.20 7.12 0.64 5.00
77 INT144701 Gene_expression of Cdkn2a 15 0.75 8.42 0.53 5.00
78 INT156254 Gene_expression of Six1 7 0.67 1.52 0.51 5.00
79 INT196426 Gene_expression of Cdkn2b 6 0.67 4.29 0.29 5.00
80 INT301935 Gene_expression of UCK2 5 0.13 4.4 0.27 5.00
81 INT232628 Gene_expression of Opa1 10 0.78 17.01 0.26 5.00
82 INT241687 Binding of Cdkn2a 5 0.31 5.26 0.18 5.00
83 INT194332 Localization of MFN2 2 0.74 1.45 0.15 5.00
84 INT302703 Binding of PLAA 1 0.13 0.87 0.15 5.00
85 INT302683 Negative_regulation of PLAA 1 0.15 0.4 0.13 5.00
86 INT285504 Gene_expression of Cdc7 2 0.44 1.31 0.1 5.00
87 INT177342 Negative_regulation of SRGN 15 0.28 5.66 0.04 5.00
88 INT329018 Binding of SRGN 1 0.23 1.21 0.03 5.00
89 INT329019 Negative_regulation of Binding of SRGN 1 0.28 1.22 0.03 5.00
90 INT314842 Phosphorylation of Cdkn2b 1 0.71 0.61 0.03 5.00
91 INT314840 Regulation of Gene_expression of Atoh7 1 0.41 0.26 0 5.00
92 INT314846 Gene_expression of Pbld1 1 0.30 0.37 0 5.00
93 INT302701 Positive_regulation of PLAA 1 0.18 0 0 5.00
94 INT329017 Binding of GON4L 1 0.04 0.43 0 5.00
95 INT265513 Binding of Opa1 2 0.48 5.75 0 5.00
96 INT302688 Transcription of OPA1 1 0.68 0.3 0 5.00
97 INT314847 Gene_expression of Six6 1 0.55 0.37 0 5.00
98 INT314820 Binding of Cdc7 1 0.32 0.09 0 5.00
99 INT302687 Regulation of PLAA 1 0.19 0.24 0 5.00
100 INT314824 Localization of Ltbp3 1 0.66 0.26 0 5.00
101 INT314839 Binding of Tgfbr3 1 0.42 0.09 0 5.00
102 INT314843 Positive_regulation of Gene_expression of Atoh7 1 0.63 0.27 0 5.00
103 INT314823 Negative_regulation of Ltbp3 1 0.38 0.1 0 5.00
104 INT314836 Gene_expression of Tgfbr3 1 0.59 0.09 0 5.00
105 INT314825 Gene_expression of Atoh7 1 0.71 1.46 0 5.00
106 INT265514 Negative_regulation of COX1 1 0.42 0.82 0 5.00
107 INT274268 Localization of OPA2 1 0.12 1.48 0 5.00
108 INT232633 Regulation of Gene_expression of Opa1 2 0.27 2.6 0 5.00
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