D:Autosomal Recessive Polycystic Kidney

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Disease Term
Synonyms ARPKD, Autosomal Recessive Polycystic Kidney Disease, KIDNEY POLYCYSTIC AUTOSOMAL RECESSIVE, POLYCYSTIC KIDNEY DISEASE INFANTILE TYPE I, Polycystic Kidney Hepatic Disease 1 Autosomal Recessive
Documents 7
Hot Single Events 0
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Autosomal Recessive Polycystic Kidney. They are ordered first by their relevance to Autosomal Recessive Polycystic Kidney and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT241772 AVP Positive_regulation of ADCY1 1 0.09 1.08 0.15 79.24
2 INT241777 Negative_regulation of Binding of AVP and TRGV9 1 0.10 0.75 0.13 51.36
3 INT241780 Binding of AVP and TRGV9 1 0.12 2.41 0.35 51.04
4 INT241776 Binding of AVP and Positive_regulation of ADCY1 1 0.06 0.54 0.32 5.00
5 INT241248 Binding of Pkd1 and Pkd2 3 0.22 1.52 0.1 5.00
6 INT286568 Car2 Positive_regulation of Positive_regulation of Pkd1 1 0.03 0.16 0.09 5.00
7 INT241774 Binding of AVPR1A and TRGV9 1 0.02 0.48 0.09 5.00
8 INT286565 Pkd2 Positive_regulation of Positive_regulation of Pkd1 1 0.21 0.11 0.09 5.00
9 INT286592 Binding of PKD1 and P1Ehs1 1 0.00 0.16 0.06 5.00
10 INT286563 Binding of Id2 and P1Ehs1 1 0.00 0.17 0.06 5.00
11 INT286591 Binding of PKD1 and Id2 1 0.07 0.17 0.06 5.00
12 INT241775 AVP Positive_regulation of Gene_expression of AQP2 1 0.08 0.17 0 5.00
13 INT286566 Binding of Ctnnb1 and Cdh6 1 0.00 1 0 5.00
14 INT286562 Gene_expression of Pkd1 Positive_regulation of Ctnnb1 1 0.02 0.52 0 5.00
15 INT241779 AVP Positive_regulation of TRGV9 1 0.17 0.48 0 5.00
16 INT286571 Binding of Prkd1 and Pkd1 1 0.05 0.76 0 5.00
17 INT241769 AVP Regulation of Binding of AVPR1A 1 0.11 0.49 0 5.00
18 INT241771 Binding of AVP and AVPR1B 1 0.04 0.49 0 5.00
19 INT241778 AVP Positive_regulation of AVPR1A 1 0.10 1.32 0 5.00
20 INT286574 Gene_expression of Pkd1 Negative_regulation of Cdk2 1 0.10 0.09 0 5.00
21 INT286570 Pkd2 Positive_regulation of Binding of Pkd1 1 0.21 0.73 0 5.00
22 INT286501 Binding of PKD1 and LILRB1 1 0.01 1.07 0 5.00
23 INT286561 Binding of Ctnnb1 and Cdh2 1 0.00 1.06 0 5.00
24 INT286593 Binding of Pkd1 and GOPC 1 0.02 1.13 0 5.00
25 INT286589 Binding of PKHD1 and Pkd2 1 0.09 0.52 0 5.00
26 INT286567 Prkd1 Regulation of Ctnnb1 1 0.01 0.39 0 5.00
27 INT241768 Binding of AVP and AVPR1A 1 0.08 0.49 0 5.00
28 INT286573 Pkd2 Regulation of Pkd1 1 0.12 0.25 0 5.00
29 INT286564 Pkd1 Regulation of Mtor 1 0.00 0.51 0 5.00
30 INT286569 Binding of Pkd1 and Tsc2 1 0.06 1.01 0 5.00
31 INT286590 Binding of ID2 and Pkd2 1 0.13 0.13 0 5.00
32 INT241770 AVP Regulation of Binding of TRGV9 1 0.11 0.49 0 5.00
33 INT241773 AVP Regulation of Binding of AVPR1B 1 0.05 0.49 0 5.00
34 INT286572 Binding of Ctnnb1 and Pkd1 1 0.02 0.96 0 5.00
35 INT286594 Binding of LILRB1 and Pkd1 1 0.01 1.07 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Autosomal Recessive Polycystic Kidney. They are ordered first by their pain relevance and then by number of times they were reported in Autosomal Recessive Polycystic Kidney. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT176618 Gene_expression of HEY1 29 0.59 36 4.37 64.36
2 INT177594 Binding of TRGV9 7 0.14 3.28 0.33 50.88
3 INT241790 Negative_regulation of AVPR1A 6 0.57 4.62 0.35 47.84
4 INT241292 Transcription of TRGV9 2 0.16 1.13 0.12 44.16
5 INT112425 Gene_expression of TRGV9 15 0.58 7.34 2.49 32.12
6 INT684 Binding of AVP 38 0.48 13.9 8.85 22.64
7 INT695 Binding of POMC 304 0.48 56.66 126.85 5.00
8 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
9 INT397 Localization of SST 232 0.81 58.05 101.19 5.00
10 INT3537 Positive_regulation of Car2 413 0.56 103.51 94.35 5.00
11 INT214 Localization of AVP 370 0.81 208.51 91.09 5.00
12 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.00
13 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 5.00
14 INT30170 Gene_expression of Car2 330 0.66 77.26 46.76 5.00
15 INT683 Positive_regulation of AVP 173 0.70 74.55 46.41 5.00
16 INT17561 Localization of Car2 303 0.79 60.95 44.52 5.00
17 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
18 INT685 Regulation of AVP 124 0.62 34.9 39.91 5.00
19 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 5.00
20 INT70437 Negative_regulation of Mdk 115 0.57 41.03 35.72 5.00
21 INT3679 Gene_expression of AVP 171 0.78 72.9 35.23 5.00
22 INT5426 Negative_regulation of RTCA 58 0.51 12.34 25.74 5.00
23 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 5.00
24 INT682 Negative_regulation of AVP 97 0.59 50.67 23.91 5.00
25 INT6127 Regulation of Localization of AVP 60 0.62 15.12 20.84 5.00
26 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45 5.00
27 INT213 Negative_regulation of Localization of AVP 46 0.59 19.78 16.79 5.00
28 INT6129 Positive_regulation of Localization of AVP 63 0.70 30.44 16.64 5.00
29 INT98647 Positive_regulation of Mdk 65 0.59 32.93 15.67 5.00
30 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 5.00
31 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 5.00
32 INT170601 Positive_regulation of Gene_expression of GOPC 122 0.43 42.79 11.68 5.00
33 INT81640 Positive_regulation of Gene_expression of Bcl2 106 0.69 84.58 11.63 5.00
34 INT44550 Positive_regulation of Gene_expression of AVP 38 0.70 22.27 8.62 5.00
35 INT111607 Gene_expression of CDH1 103 0.75 90.45 7.77 5.00
36 INT87022 Gene_expression of Apc 68 0.67 46.98 5.22 5.00
37 INT24080 Negative_regulation of Mtor 64 0.37 41.56 5.19 5.00
38 INT11158 Positive_regulation of Gene_expression of EGFR 165 0.70 131.26 4.93 5.00
39 INT187286 Binding of HEY1 17 0.32 31.21 4.52 5.00
40 INT3817 Negative_regulation of Apc 29 0.58 22.12 3.91 5.00
41 INT31757 Negative_regulation of Egf 18 0.41 9.7 2.94 5.00
42 INT104182 Gene_expression of ABCC2 19 0.76 5.92 2.88 5.00
43 INT10848 Negative_regulation of Gene_expression of AVP 13 0.59 6.76 2.71 5.00
44 INT4686 Gene_expression of Cys1 32 0.66 36.24 2.49 5.00
45 INT174979 Phosphorylation of GOPC 45 0.51 10.11 2.28 5.00
46 INT46160 Regulation of Positive_regulation of AVP 4 0.53 0.99 2.14 5.00
47 INT80862 Negative_regulation of CYP3A5 5 0.57 1.66 2.13 5.00
48 INT81641 Gene_expression of Ctnnb1 23 0.72 14.93 1.97 5.00
49 INT65545 Localization of EGFR 35 0.79 20.8 1.88 5.00
50 INT110434 Positive_regulation of Gene_expression of Apc 20 0.50 11.37 1.3 5.00
51 INT139237 Negative_regulation of Gene_expression of CDH1 23 0.57 24.31 1.28 5.00
52 INT118668 Negative_regulation of TRGV9 6 0.37 2.58 1.23 5.00
53 INT100328 Gene_expression of AQP2 6 0.75 2.41 1.21 5.00
54 INT188396 Positive_regulation of Positive_regulation of GOPC 13 0.42 1.78 1.21 5.00
55 INT157765 Negative_regulation of CDH1 32 0.53 35.72 1.15 5.00
56 INT151774 Positive_regulation of Mtor 38 0.45 20.15 1.01 5.00
57 INT101687 Positive_regulation of AVPR1B 6 0.40 2.95 0.95 5.00
58 INT25539 Regulation of Gene_expression of AVP 9 0.45 2.74 0.89 5.00
59 INT124850 Gene_expression of Tpt1 42 0.77 14.51 0.79 5.00
60 INT134207 Gene_expression of Ptk2 56 0.73 31.97 0.78 5.00
61 INT114880 Negative_regulation of Cdk2 7 0.35 3.89 0.77 5.00
62 INT129174 Gene_expression of PKD1 24 0.67 14.91 0.74 5.00
63 INT27220 Binding of CYP3A5 4 0.47 0.53 0.73 5.00
64 INT241788 Positive_regulation of Gene_expression of AQP2 3 0.67 1.26 0.7 5.00
65 INT1939 Localization of Cys1 6 0.73 5.9 0.64 5.00
66 INT137850 Gene_expression of PKD2 9 0.65 6.68 0.63 5.00
67 INT241235 Binding of Pkd2 11 0.48 2.43 0.55 5.00
68 INT241243 Gene_expression of Pkd2 30 0.77 9.05 0.53 5.00
69 INT134208 Negative_regulation of Ptk2 19 0.58 23.59 0.52 5.00
70 INT81645 Positive_regulation of Gene_expression of Ctnnb1 6 0.63 3.78 0.47 5.00
71 INT286550 Negative_regulation of Prkd1 4 0.42 3.68 0.45 5.00
72 INT209189 Binding of AVPR1A 5 0.29 1.94 0.43 5.00
73 INT76958 Positive_regulation of Ctnnb1 14 0.64 5.48 0.41 5.00
74 INT150826 Positive_regulation of Pkd1 9 0.37 3.65 0.35 5.00
75 INT283683 Binding of Id2 5 0.35 0.8 0.35 5.00
76 INT226835 Gene_expression of Cdh2 14 0.22 8.04 0.31 5.00
77 INT241240 Gene_expression of Pkd1 18 0.54 12.2 0.27 5.00
78 INT241238 Positive_regulation of Pkd2 5 0.46 1.44 0.24 5.00
79 INT286538 Gene_expression of Prkd1 7 0.56 3.97 0.24 5.00
80 INT282798 Binding of Prkd1 2 0.18 2.11 0.19 5.00
81 INT208476 Binding of Pkd1 13 0.39 7.23 0.17 5.00
82 INT112424 Gene_expression of AVPR1B 6 0.65 1.35 0.16 5.00
83 INT286532 Localization of Prkd1 3 0.58 3.02 0.16 5.00
84 INT230524 Binding of LILRB1 2 0.35 2.14 0.15 5.00
85 INT286548 Positive_regulation of Prkd1 7 0.36 4.35 0.15 5.00
86 INT200585 Negative_regulation of Binding of AVP 3 0.39 0.61 0.14 5.00
87 INT241783 Positive_regulation of AVPR1A 2 0.67 1.34 0.14 5.00
88 INT271941 Binding of Tsc2 12 0.24 2.96 0.11 5.00
89 INT283708 Localization of Id2 2 0.71 0.72 0.11 5.00
90 INT283560 Negative_regulation of Gene_expression of Ptk2 6 0.40 4.84 0.09 5.00
91 INT286583 Localization of PKD2 1 0.35 0.17 0.06 5.00
92 INT235057 Positive_regulation of Negative_regulation of Apc 2 0.30 0.66 0.05 5.00
93 INT211006 Binding of PKD1 6 0.22 2.69 0.05 5.00
94 INT286547 Negative_regulation of Kif3a 1 0.15 0.48 0.05 5.00
95 INT286535 Regulation of Prkd1 3 0.33 2.24 0.04 5.00
96 INT247803 Positive_regulation of Cdh2 2 0.11 2.03 0.04 5.00
97 INT177599 Binding of AVPR1B 2 0.04 0.49 0.04 5.00
98 INT286543 Localization of Pkd1 5 0.52 3.74 0.04 5.00
99 INT238180 Binding of Ptk2 5 0.35 2.99 0.04 5.00
100 INT286581 Gene_expression of PKHD1 1 0.24 0.19 0.03 5.00
101 INT286533 Negative_regulation of Gene_expression of Cdh2 1 0.11 1.4 0.03 5.00
102 INT282568 Positive_regulation of Cdk2 6 0.34 2.95 0.03 5.00
103 INT241787 Negative_regulation of AQP2 1 0.57 1.38 0.03 5.00
104 INT241241 Positive_regulation of Gene_expression of Pkd2 3 0.50 1.3 0.03 5.00
105 INT286580 Positive_regulation of Gene_expression of PKHD1 1 0.16 0.1 0.03 5.00
106 INT286551 Binding of Pxn 1 0.08 0.94 0 5.00
107 INT286556 Binding of Neat1 1 0.05 0.94 0 5.00
108 INT286582 Localization of BBS1 1 0.02 0.74 0 5.00
109 INT286577 Binding of ID2 1 0.19 0.12 0 5.00
110 INT286555 Binding of Ift88 1 0.30 0.08 0 5.00
111 INT286588 Positive_regulation of Localization of PKHD1 1 0.16 0.79 0 5.00
112 INT258949 Localization of OFD1 2 0.41 3.87 0 5.00
113 INT283691 Binding of Aatf 2 0.03 0.19 0 5.00
114 INT286541 Negative_regulation of Cdh2 1 0.03 1.09 0 5.00
115 INT286545 Positive_regulation of Gene_expression of Pkd1 1 0.42 1.55 0 5.00
116 INT286576 Binding of PKHD1 1 0.12 0.63 0 5.00
117 INT286558 Transcription of Nek8 1 0.46 0.7 0 5.00
118 INT286539 Localization of Nek8 1 0.57 0.73 0 5.00
119 INT286552 Positive_regulation of Localization of Nek8 1 0.38 0.73 0 5.00
120 INT286549 Regulation of Tsc2 1 0.11 0.42 0 5.00
121 INT286578 Localization of ALMS1 1 0.22 0.75 0 5.00
122 INT271919 Gene_expression of Tsc2 6 0.39 2.23 0 5.00
123 INT286557 Regulation of Binding of Aatf 1 0.02 0 0 5.00
124 INT120527 Localization of ABCC2 3 0.78 1.03 0 5.00
125 INT286585 Positive_regulation of Localization of ALMS1 1 0.15 0.75 0 5.00
126 INT286542 Binding of Vcl 1 0.04 0.94 0 5.00
127 INT286544 Localization of Ift88 1 0.52 1.26 0 5.00
128 INT286537 Gene_expression of Cdh6 1 0.04 0.98 0 5.00
129 INT150827 Regulation of Pkd1 4 0.32 2.18 0 5.00
130 INT286554 Negative_regulation of Gene_expression of Pkd1 1 0.35 1.77 0 5.00
131 INT286534 Negative_regulation of Gene_expression of Prkd1 2 0.31 0.89 0 5.00
132 INT286586 Positive_regulation of Localization of OFD1 1 0.12 0.74 0 5.00
133 INT286540 Localization of Btk 1 0.28 1.26 0 5.00
134 INT286587 Negative_regulation of LAMA3 1 0.01 1.01 0 5.00
135 INT286559 Positive_regulation of Gene_expression of Cdh2 1 0.04 1.04 0 5.00
136 INT286584 Positive_regulation of PKHD1 1 0.13 1.01 0 5.00
137 INT286536 Positive_regulation of Positive_regulation of Prkd1 1 0.08 1.28 0 5.00
138 INT271915 Negative_regulation of Pkd1 8 0.36 6.44 0 5.00
139 INT283566 Localization of Ptk2 5 0.75 0.93 0 5.00
140 INT169921 Negative_regulation of Gene_expression of Tpt1 3 0.25 1.38 0 5.00
141 INT286579 Localization of PKHD1 1 0.24 0.79 0 5.00
142 INT286553 Transcription of Prkd1 1 0.12 0.7 0 5.00
143 INT286546 Negative_regulation of Gene_expression of Pkd2 2 0.27 0.57 0 5.00
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