D:B-cell Acute Lymphoblastic Leukemia

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Disease Term
Synonyms Acute Lymphoblastic Leukemia Of B Cells, B Cell Acute Lymphoblastic Leukemia, B Cell Leukemia, B Cell Leukemias, B Cell Lymphocytic Leukemia, B Cell Lymphocytic Leukemias, B LYMPHOCYTIC LEUKEMIA, B Lymphocytic Leukemias, Leukemia B Cell, Leukemia B Cell Lymphocytic, Leukemia B Lymphocytic
Documents 7
Hot Single Events 13
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for B-cell Acute Lymphoblastic Leukemia. They are ordered first by their relevance to B-cell Acute Lymphoblastic Leukemia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT335022 Fgf15 Regulation of Pbx1 1 0.15 0.17 0 90.76
2 INT352148 Ift88 Negative_regulation of Bcl2l2 1 0.00 0.19 0 46.64
3 INT352149 Ift88 Negative_regulation of Bcl2l1 1 0.00 0.19 0 45.76
4 INT352150 Ift88 Negative_regulation of Bcl2 1 0.00 0.19 0 45.12
5 INT335027 Binding of Vdr and Fgf23 1 0.24 0.34 0.29 5.00
6 INT335028 Fgf15 Positive_regulation of Fgfr4 1 0.40 0.31 0.25 5.00
7 INT335015 Fgf15 Negative_regulation of Gene_expression of Cyp7a1 1 0.57 0.2 0.24 5.00
8 INT335021 Fgf23 Negative_regulation of Gene_expression of Cyp27b1 1 0.53 1.49 0.21 5.00
9 INT335025 Gm7647 Positive_regulation of Gene_expression of Fgf21 1 0.01 0.29 0.21 5.00
10 INT335020 Fgf23 Positive_regulation of Gene_expression of Cyp24a1 1 0.62 0.82 0.18 5.00
11 INT335018 Vdr Positive_regulation of Gene_expression of Fgf23 1 0.44 0.36 0.17 5.00
12 INT335026 Positive_regulation of Fgf23 Positive_regulation of Gene_expression of Cyp24a1 1 0.45 0.2 0.13 5.00
13 INT335024 Positive_regulation of Fgf23 Negative_regulation of Gene_expression of Cyp27b1 1 0.39 0.19 0.13 5.00
14 INT335023 Fgf21 Positive_regulation of Gene_expression of Igf1 1 0.49 0.65 0.05 5.00
15 INT335017 Fgf23 Positive_regulation of Fgfr1 1 0.23 0.59 0.04 5.00
16 INT172902 Binding of Bax and Bcl2 5 0.30 3.19 0.03 5.00
17 INT335016 Fgf23 Negative_regulation of Gene_expression of Slc34a3 1 0.03 0.63 0.03 5.00
18 INT335013 Fgf21 Positive_regulation of Localization of Ins1 1 0.06 0.58 0 5.00
19 INT335012 Fgf21 Positive_regulation of Gene_expression of Ins1 1 0.06 0.57 0 5.00
20 INT352151 Binding of Bak1 and Gopc 1 0.02 0.26 0 5.00
21 INT283013 Binding of Bak1 and Bcl2 4 0.06 1.03 0 5.00
22 INT335019 Fgf23 Positive_regulation of Phosphorylation of Mapk1 1 0.08 0.45 0 5.00
23 INT296929 Gene_expression of Casq1 Positive_regulation of Tmie 1 0.00 0.43 0 5.00
24 INT296930 Casq1 Negative_regulation of RYR1 1 0.00 0.38 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for B-cell Acute Lymphoblastic Leukemia. They are ordered first by their pain relevance and then by number of times they were reported in B-cell Acute Lymphoblastic Leukemia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03 100.00
2 INT100422 Negative_regulation of Gene_expression of Bcl2 46 0.58 28.86 5.7 100.00
3 INT236711 Gene_expression of Bcl6 15 0.30 12.98 0.58 100.00
4 INT172452 Gene_expression of Myc 121 0.78 69.56 1.36 98.40
5 INT172445 Positive_regulation of Gene_expression of Myc 58 0.70 39.62 0.25 98.40
6 INT100423 Gene_expression of Bax 141 0.75 98.43 24.48 98.04
7 INT102110 Positive_regulation of Gene_expression of Bax 42 0.67 35.77 9.51 98.04
8 INT102107 Negative_regulation of Gene_expression of Bax 30 0.57 29.48 7.33 95.96
9 INT192056 Binding of Pbx1 2 0.31 0.46 0.13 92.88
10 INT334975 Gene_expression of Fgf15 1 0.74 7.12 2.02 90.76
11 INT22548 Positive_regulation of Casp3 483 0.70 258.78 213.07 90.08
12 INT192055 Gene_expression of Pbx1 3 0.65 0.57 0 88.84
13 INT114702 Gene_expression of Fgf1 34 0.74 17.39 2.96 85.36
14 INT27493 Negative_regulation of Casp3 114 0.56 56.89 44.63 78.80
15 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 75.76
16 INT86705 Gene_expression of BTG3 41 0.65 37.29 8.29 75.28
17 INT764 Gene_expression of OLAH 25 0.67 25.58 8.07 75.28
18 INT33094 Regulation of Localization of Ca2 28 0.38 8.65 9.96 75.16
19 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 74.96
20 INT81640 Positive_regulation of Gene_expression of Bcl2 106 0.69 84.58 11.63 74.96
21 INT4822 Localization of Ca2 417 0.80 99.57 96.45 73.64
22 INT1033 Positive_regulation of Ca2 507 0.68 131.76 147.64 71.52
23 INT149739 Regulation of Gene_expression of Ca2 25 0.38 7.22 5.53 65.24
24 INT13286 Gene_expression of Ca2 317 0.67 71.58 65.01 64.76
25 INT200115 Negative_regulation of Gene_expression of Atp2b1 2 0.16 2.61 0 52.64
26 INT172855 Binding of Bcl2 37 0.32 23.41 1.09 52.60
27 INT172216 Binding of Bak1 5 0.25 8.48 0.33 52.60
28 INT199844 Binding of Bid 3 0.24 3.92 0.19 52.60
29 INT352131 Binding of Bcl2l11 1 0.05 4.17 0.05 52.60
30 INT88182 Gene_expression of Atp2a2 40 0.78 22.91 4.26 52.24
31 INT200114 Gene_expression of Atp2b1 2 0.29 2.6 0 52.24
32 INT334998 Positive_regulation of Fgf21 1 0.66 4.8 0.14 48.92
33 INT118371 Positive_regulation of Fgf23 15 0.69 25.34 0.85 47.48
34 INT86246 Binding of Bcl2l1 8 0.37 6.67 0.57 45.48
35 INT296919 Transcription of Slc8a1 1 0.24 1.28 0 43.52
36 INT296926 Transcription of Casq1 1 0.10 1.85 0 43.52
37 INT296918 Positive_regulation of Transcription of Slc8a1 1 0.21 1.29 0 43.52
38 INT75919 Gene_expression of Slc8a1 23 0.63 16.44 9.84 42.76
39 INT166810 Gene_expression of Casq1 2 0.10 2.16 0.08 42.76
40 INT281600 Positive_regulation of Casq1 2 0.05 0.66 0 41.96
41 INT296913 Positive_regulation of Transcription of Atp2a2 1 0.02 1.33 0 36.92
42 INT296924 Positive_regulation of Positive_regulation of Atp2a2 1 0.02 0.67 0 36.92
43 INT99427 Positive_regulation of Gene_expression of Atp2a2 5 0.64 4.13 1.14 36.32
44 INT201163 Regulation of Atp2a2 4 0.08 2.97 0.03 36.32
45 INT296910 Regulation of Gene_expression of Slc8a1 1 0.18 0.68 0 36.32
46 INT296915 Positive_regulation of Atp2b1 1 0.17 1.24 0 36.32
47 INT296920 Regulation of Transcription of Atp2b1 1 0.17 0.67 0 36.32
48 INT296925 Regulation of Atp2b1 1 0.17 0.67 0 36.32
49 INT296917 Regulation of Gene_expression of Atp2b1 1 0.17 0.67 0 36.32
50 INT296912 Positive_regulation of Atp2a2 1 0.02 0.66 0 36.32
51 INT240720 Transcription of Atp2a2 2 0.20 1.26 0 35.56
52 INT296921 Transcription of Atp2b1 1 0.26 1.24 0 35.56
53 INT241034 Negative_regulation of Gene_expression of Slc8a1 4 0.34 2.23 0.48 33.24
54 INT1032 Regulation of Ca2 202 0.52 54.91 53.03 30.52
55 INT49536 Regulation of Regulation of Ca2 6 0.38 3.89 1.13 30.52
56 INT166811 Regulation of Casq1 3 0.04 1.18 0.1 30.52
57 INT296909 Regulation of Transcription of Casq1 1 0.08 1.15 0 30.52
58 INT119936 Transcription of Ca2 13 0.59 1.71 1.47 29.80
59 INT352129 Negative_regulation of Ift88 1 0.00 0.72 0.05 29.40
60 INT296914 Regulation of Pln 2 0.19 3.08 1.23 23.92
61 INT267804 Gene_expression of Pln 4 0.47 1.45 0.51 23.92
62 INT296923 Regulation of Gene_expression of Pln 1 0.15 0.63 0 23.92
63 INT6508 Gene_expression of RYR1 34 0.77 11.11 2.04 23.56
64 INT138467 Gene_expression of Ryr2 5 0.55 2.36 0.98 22.76
65 INT138466 Regulation of Gene_expression of Ryr2 3 0.28 1.62 0.39 22.76
66 INT84496 Regulation of Positive_regulation of Ephb1 18 0.61 10.16 13.92 18.56
67 INT241036 Regulation of Slc8a1 5 0.22 3.43 0.37 17.96
68 INT63932 Positive_regulation of Ephb1 537 0.70 259.67 296.14 16.24
69 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
70 INT14151 Gene_expression of Casp3 311 0.78 140.26 120.68 5.00
71 INT48923 Gene_expression of Ephb1 211 0.77 106.23 109.9 5.00
72 INT2520 Negative_regulation of Ca2 271 0.57 72.13 83.71 5.00
73 INT92434 Phosphorylation of Mapk1 287 0.82 91.65 83.46 5.00
74 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 5.00
75 INT3214 Localization of Ins1 527 0.80 196.9 79.26 5.00
76 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71 5.00
77 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 5.00
78 INT84495 Positive_regulation of Positive_regulation of Ephb1 85 0.70 46.12 54.11 5.00
79 INT3213 Gene_expression of Ins1 511 0.76 357.59 53.32 5.00
80 INT3216 Positive_regulation of Localization of Ins1 170 0.69 56.78 35.63 5.00
81 INT14559 Gene_expression of Igf1 254 0.78 112 34.17 5.00
82 INT18322 Negative_regulation of Ins1 132 0.58 88.49 22.59 5.00
83 INT83797 Gene_expression of Bcl2l1 124 0.77 94.55 22.39 5.00
84 INT93734 Positive_regulation of Gene_expression of Bcl2 76 0.70 61.95 18.46 5.00
85 INT86673 Positive_regulation of Bcl2 77 0.70 57.74 17.37 5.00
86 INT38253 Localization of Trib3 35 0.63 10.28 15.42 5.00
87 INT109511 Gene_expression of Bax 133 0.78 113.22 14.36 5.00
88 INT19799 Binding of Ca2 71 0.48 13.69 12.92 5.00
89 INT38255 Localization of Chkb 32 0.80 10.98 11.07 5.00
90 INT92680 Gene_expression of Fgf2 59 0.77 28.11 8.12 5.00
91 INT127853 Localization of Ephb1 20 0.74 5.47 7.96 5.00
92 INT98837 Positive_regulation of Bax 72 0.61 63.14 6.41 5.00
93 INT57232 Binding of Casp3 22 0.36 9.42 6.2 5.00
94 INT109513 Positive_regulation of Gene_expression of Bax 37 0.67 29.52 5.06 5.00
95 INT99504 Negative_regulation of Bax 19 0.56 8.89 4.44 5.00
96 INT72747 Localization of IgG 55 0.53 30.88 4.19 5.00
97 INT38256 Negative_regulation of Localization of Chkb 10 0.56 3.58 4.11 5.00
98 INT112692 Localization of Bax 31 0.80 20.97 3.98 5.00
99 INT116143 Positive_regulation of Casp9 32 0.67 30.34 3.04 5.00
100 INT163780 Gene_expression of Nucb2 11 0.77 5.1 2.94 5.00
101 INT39908 Gene_expression of Cyp27b1 16 0.69 4.8 2.83 5.00
102 INT45253 Positive_regulation of Ltf 20 0.69 10.22 2.77 5.00
103 INT70253 Negative_regulation of Gene_expression of Ca2 29 0.49 16.31 2.69 5.00
104 INT118518 Positive_regulation of Slc8a1 7 0.56 5.31 2.59 5.00
105 INT314554 Gene_expression of Fgf21 3 0.74 7.97 2.48 5.00
106 INT176205 Gene_expression of Cyp7a1 8 0.69 2.5 2.45 5.00
107 INT101641 Gene_expression of Mcl1 25 0.54 20.3 2.23 5.00
108 INT154970 Localization of Bax 15 0.74 11.12 2.11 5.00
109 INT3179 Positive_regulation of SCT 15 0.50 4.79 1.98 5.00
110 INT112698 Gene_expression of Bid 8 0.64 6.52 1.97 5.00
111 INT99426 Negative_regulation of Gene_expression of Atp2a2 19 0.59 13.7 1.96 5.00
112 INT2409 Binding of SCT 7 0.48 2.69 1.94 5.00
113 INT197372 Gene_expression of Tmie 16 0.51 9.08 1.9 5.00
114 INT135540 Negative_regulation of Bax 16 0.48 11.8 1.89 5.00
115 INT101108 Localization of Bcl2 16 0.72 11.68 1.86 5.00
116 INT135959 Negative_regulation of Gene_expression of Igf1 37 0.56 21.16 1.41 5.00
117 INT262123 Gene_expression of Cyp24a1 17 0.67 6.67 1.38 5.00
118 INT123754 Gene_expression of Bcl2l2 4 0.65 4.36 1.38 5.00
119 INT332832 Positive_regulation of Gene_expression of Fgf21 2 0.66 3.18 1.29 5.00
120 INT228128 Gene_expression of Bcl2l11 31 0.67 18.31 1.25 5.00
121 INT170900 Regulation of Positive_regulation of Gopc 10 0.20 3.44 1.24 5.00
122 INT120421 Gene_expression of Fgf13 6 0.68 0.45 1.12 5.00
123 INT118373 Gene_expression of Fgf23 16 0.77 29.62 1.04 5.00
124 INT80500 Localization of Slc8a1 4 0.61 1.37 1.02 5.00
125 INT93094 Gene_expression of Bak1 13 0.52 13.94 1.02 5.00
126 INT76472 Gene_expression of Dntt 14 0.65 8.51 0.95 5.00
127 INT334977 Regulation of Gene_expression of Cyp7a1 2 0.40 0.43 0.94 5.00
128 INT228130 Positive_regulation of Bcl2l11 14 0.49 10 0.9 5.00
129 INT114704 Positive_regulation of Fgf1 13 0.50 8.89 0.89 5.00
130 INT135542 Positive_regulation of Bak1 17 0.43 16.12 0.88 5.00
131 INT164669 Positive_regulation of Nucb2 3 0.31 1.67 0.84 5.00
132 INT262107 Binding of Vdr 9 0.48 6.56 0.71 5.00
133 INT335005 Regulation of Gene_expression of Fgf15 1 0.58 0.8 0.66 5.00
134 INT184030 Gene_expression of Socs2 8 0.74 3.54 0.63 5.00
135 INT262093 Positive_regulation of Gene_expression of Cyp7a1 2 0.44 0.81 0.55 5.00
136 INT211608 Negative_regulation of Nucb2 4 0.12 2.8 0.55 5.00
137 INT184038 Negative_regulation of Socs2 5 0.31 1.68 0.51 5.00
138 INT32137 Regulation of Negative_regulation of Ca2 7 0.36 2.17 0.49 5.00
139 INT241035 Positive_regulation of Gene_expression of Slc8a1 4 0.41 1.89 0.47 5.00
140 INT303541 Gene_expression of Fgfr4 2 0.62 0.72 0.43 5.00
141 INT221191 Negative_regulation of Localization of Bax 4 0.38 2.85 0.33 5.00
142 INT334987 Positive_regulation of Fgf15 1 0.66 2.32 0.31 5.00
143 INT140379 Positive_regulation of Gene_expression of Bak1 4 0.27 2.27 0.31 5.00
144 INT135880 Positive_regulation of Gene_expression of Fgf23 4 0.46 7.52 0.29 5.00
145 INT149737 Positive_regulation of Regulation of Ca2 3 0.58 1 0.27 5.00
146 INT334990 Regulation of Positive_regulation of Fgfr4 1 0.36 0.25 0.25 5.00
147 INT334992 Positive_regulation of Fgfr4 1 0.40 0.24 0.25 5.00
148 INT335010 Positive_regulation of Gene_expression of Fgf15 1 0.48 0.2 0.24 5.00
149 INT135543 Negative_regulation of Positive_regulation of Bax 5 0.30 6.4 0.23 5.00
150 INT334978 Binding of Nucb2 2 0.07 0.26 0.22 5.00
151 INT120423 Positive_regulation of Gene_expression of Fgf13 2 0.44 0.09 0.22 5.00
152 INT303539 Binding of Fgfr1 3 0.45 0.96 0.2 5.00
153 INT282088 Localization of Bak1 6 0.54 3.78 0.19 5.00
154 INT334995 Localization of Nucb2 1 0.12 0.65 0.18 5.00
155 INT334996 Positive_regulation of Localization of Nucb2 1 0.07 0.18 0.18 5.00
156 INT118372 Regulation of Fgf23 4 0.55 3.31 0.15 5.00
157 INT258953 Negative_regulation of Gene_expression of Bcl6 1 0.19 1.53 0.14 5.00
158 INT236693 Positive_regulation of Gene_expression of Bcl6 3 0.15 2.06 0.14 5.00
159 INT214132 Regulation of Nucb2 2 0.04 0.33 0.14 5.00
160 INT334985 Binding of Fgf15 1 0.30 0.53 0.13 5.00
161 INT296902 Regulation of Gene_expression of Tmie 2 0.23 1.23 0.12 5.00
162 INT258955 Localization of Bcl6 1 0.23 0.83 0.11 5.00
163 INT319782 Localization of Bid 2 0.30 1.06 0.1 5.00
164 INT275179 Localization of Bad 2 0.69 0.66 0.09 5.00
165 INT334999 Regulation of Fgf21 1 0.43 2.33 0.09 5.00
166 INT344260 Localization of BCL2L11 2 0.11 2.41 0.06 5.00
167 INT266828 Negative_regulation of Fgf23 3 0.42 5.63 0.04 5.00
168 INT205607 Regulation of Fgf1 4 0.24 3.34 0.04 5.00
169 INT303538 Positive_regulation of Fgfr1 3 0.65 0.92 0.03 5.00
170 INT295973 Gene_expression of Slc34a3 2 0.05 0.96 0.03 5.00
171 INT335006 Negative_regulation of Gene_expression of Fgf21 1 0.41 1.33 0.03 5.00
172 INT335007 Protein_catabolism of Fgf23 1 0.59 1.28 0.03 5.00
173 INT334980 Negative_regulation of Fgf21 1 0.41 2.31 0.03 5.00
174 INT334994 Gene_expression of Slc34a1 1 0.10 0.62 0.03 5.00
175 INT352130 Localization of Bmf 1 0.73 0 0.03 5.00
176 INT334982 Phosphorylation of Fgf23 1 0.73 1.21 0 5.00
177 INT335003 Negative_regulation of Localization of Fgf23 1 0.39 2.37 0 5.00
178 INT286389 Positive_regulation of Fgf13 2 0.42 0.33 0 5.00
179 INT334997 Localization of Fgf23 1 0.72 3.56 0 5.00
180 INT296911 Positive_regulation of Gene_expression of Casq1 1 0.09 1.49 0 5.00
181 INT352146 Binding of BCL2L11 1 0.07 0.36 0 5.00
182 INT296922 Negative_regulation of Casq1 1 0.06 0.38 0 5.00
183 INT296927 Localization of Casq1 1 0.10 0.32 0 5.00
184 INT296901 Positive_regulation of Gene_expression of Tmie 2 0.29 1.29 0 5.00
185 INT163623 Localization of Galnt3 2 0.63 1.42 0 5.00
186 INT334988 Localization of Fgf21 1 0.71 0.08 0 5.00
187 INT296916 Negative_regulation of Gene_expression of Casq1 1 0.06 0.44 0 5.00
188 INT335001 Positive_regulation of Gene_expression of Fgf4 1 0.13 0 0 5.00
189 INT334983 Localization of Fgf15 1 0.71 0.08 0 5.00
190 INT334991 Positive_regulation of Positive_regulation of Fgf23 1 0.39 1.5 0 5.00
191 INT334993 Negative_regulation of Gene_expression of Fgf23 1 0.38 4.1 0 5.00
192 INT334984 Regulation of Gene_expression of Fgf21 1 0.43 0.67 0 5.00
193 INT334986 Negative_regulation of Gene_expression of Nucb2 1 0.06 1.21 0 5.00
194 INT296908 Regulation of Regulation of Slc8a1 1 0.12 0.61 0 5.00
195 INT164464 Positive_regulation of Sec1 3 0.10 1.25 0 5.00
196 INT334974 Phosphorylation of Galnt3 1 0.68 1.26 0 5.00
197 INT335000 Positive_regulation of Gene_expression of Nucb2 1 0.07 1.21 0 5.00
198 INT331697 Gene_expression of Fgf4 6 0.58 1.57 0 5.00
199 INT331699 Positive_regulation of Fgf4 2 0.45 0.69 0 5.00
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