D:B-cell Chronic Lymphocytic Leukemia

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Disease Term
Synonyms B Cell Chronic Lymphocytic Leukemia, B CELL LEUKEMIA CHRONIC, B CELL LEUKEMIAS CHRONIC, B Lymphocytic Leukemia Chronic, B Lymphocytic Leukemias Chronic, Chronic B Cell Leukemia, CHRONIC B CELL LEUKEMIAS, Chronic B Lymphocytic Leukemia, CHRONIC B LYMPHOCYTIC LEUKEMIAS, Chronic Lymphoblastic Leukemia, Chronic Lymphoblastic Leukemias
Documents 34
Hot Single Events 27
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for B-cell Chronic Lymphocytic Leukemia. They are ordered first by their relevance to B-cell Chronic Lymphocytic Leukemia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT305632 Binding of BCL6 and MME 1 0.00 1.37 0 86.00
2 INT347957 Binding of PTPRC and Cxcr4 1 0.39 0.37 0 69.60
3 INT193695 Il2 Positive_regulation of Ctla4 1 0.01 1.63 0.18 5.00
4 INT193693 Binding of Myd88 and Pain1 1 0.14 0.82 0.13 5.00
5 INT193697 Apaf1 Positive_regulation of CASP9 1 0.02 1.84 0.12 5.00
6 INT193691 Positive_regulation of Positive_regulation of Bcr 1 0.01 0.07 0.08 5.00
7 INT193692 IgG2a Positive_regulation of Bcr 1 0.02 0.07 0.08 5.00
8 INT193694 IgG2a Positive_regulation of Tlr9 1 0.05 0.07 0.08 5.00
9 INT193696 Binding of CD8A and Trav6-3 1 0.00 0.85 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for B-cell Chronic Lymphocytic Leukemia. They are ordered first by their pain relevance and then by number of times they were reported in B-cell Chronic Lymphocytic Leukemia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 99.44
2 INT12887 Positive_regulation of Mme 9 0.60 15.41 2.93 98.92
3 INT50765 Positive_regulation of Fcer2a 23 0.68 10.22 2.92 98.92
4 INT72890 Positive_regulation of Gene_expression of Fcer2a 12 0.17 6.81 2.25 98.92
5 INT71870 Positive_regulation of Gene_expression of Mme 6 0.48 4.27 2 98.92
6 INT20397 Positive_regulation of Itgax 12 0.46 6.48 1.19 98.92
7 INT87329 Positive_regulation of Gene_expression of Itgax 15 0.64 10.85 0.93 98.92
8 INT209602 Positive_regulation of Gene_expression of Cd22 4 0.19 3.25 0.33 98.92
9 INT202485 Positive_regulation of Cd22 4 0.19 2.28 0.3 98.92
10 INT124296 Positive_regulation of Cd19 4 0.65 3.89 0.15 98.92
11 INT202491 Positive_regulation of Gene_expression of Cd19 3 0.42 1.29 0.09 98.92
12 INT277801 Positive_regulation of Ms4a1 2 0.44 1.95 0.06 98.92
13 INT277800 Positive_regulation of Gene_expression of Ms4a1 2 0.44 2.02 0.03 98.92
14 INT277797 Positive_regulation of Cd5 2 0.17 2.85 0 98.92
15 INT62031 Gene_expression of Cd19 27 0.65 10.39 0.93 98.76
16 INT182339 Gene_expression of Ms4a1 18 0.68 16.6 0.42 98.64
17 INT117661 Gene_expression of Cd22 7 0.30 5.69 0.62 98.52
18 INT190935 Gene_expression of Cd5 2 0.25 3.02 0.04 98.16
19 INT15054 Gene_expression of Mme 48 0.77 42.52 10.63 98.06
20 INT39417 Gene_expression of Fcer2a 65 0.76 32.1 7.37 97.94
21 INT60700 Gene_expression of Itgax 93 0.71 51.89 6.57 97.74
22 INT305634 Localization of CCND1 1 0.07 2.69 0 90.64
23 INT14201 Localization of Igh-6 9 0.81 3.29 3.36 90.64
24 INT86503 Negative_regulation of Fcer2 3 0.09 2.49 0.55 88.96
25 INT207299 Binding of BCL6 6 0.30 3.5 0.41 86.00
26 INT23317 Gene_expression of Spn 20 0.48 14.51 4.01 83.44
27 INT35027 Positive_regulation of Gene_expression of Igh-6 6 0.02 4.26 2.24 81.60
28 INT14867 Gene_expression of Igh-6 47 0.67 30.05 11.75 78.96
29 INT264641 Binding of AES 25 0.42 18.56 6.98 78.24
30 INT226691 Positive_regulation of Gene_expression of Cxcr4 14 0.57 7.9 0.9 75.84
31 INT126481 Gene_expression of Cxcr4 69 0.77 34.99 6 75.44
32 INT38670 Positive_regulation of Gene_expression of KRT20 68 0.69 23.25 5.55 64.16
33 INT191018 Positive_regulation of Gene_expression of Cd79a 12 0.26 8.01 1.05 64.16
34 INT39416 Gene_expression of Cd79a 81 0.64 45.17 6.08 64.16
35 INT200443 Positive_regulation of AES 27 0.60 22.46 3.22 60.20
36 INT188844 Gene_expression of AES 44 0.58 33.94 5.85 60.16
37 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 53.52
38 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 53.24
39 INT102572 Gene_expression of Ccnd1 79 0.69 56.37 7.34 52.84
40 INT1124 Negative_regulation of CD40LG 53 0.57 36.26 7 51.68
41 INT35910 Binding of Mme 8 0.37 4.79 3.16 51.60
42 INT236711 Gene_expression of Bcl6 15 0.30 12.98 0.58 51.24
43 INT277796 Binding of Bcl6 1 0.17 1.33 0 51.24
44 INT725 Negative_regulation of IgG 62 0.41 37.21 8.16 46.08
45 INT15804 Gene_expression of ISG20 83 0.75 44.33 10.58 44.88
46 INT57338 Gene_expression of ITGAX 31 0.75 24.62 4.39 44.88
47 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 42.40
48 INT3795 Positive_regulation of Ighm 46 0.68 22.43 6.47 42.00
49 INT277799 Binding of Ms4a1 6 0.42 3.59 0 40.88
50 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 39.32
51 INT1127 Negative_regulation of IGHG3 32 0.28 21.1 7.37 37.68
52 INT1126 Negative_regulation of CD79A 46 0.59 31.07 6 37.04
53 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
54 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
55 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 5.00
56 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 5.00
57 INT27096 Positive_regulation of Nfkb1 325 0.70 195.11 109.06 5.00
58 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
59 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43 5.00
60 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 5.00
61 INT11807 Gene_expression of Il2 266 0.78 112 64.97 5.00
62 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 5.00
63 INT63975 Positive_regulation of Il10 175 0.68 134.13 54.69 5.00
64 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53 5.00
65 INT19775 Localization of Il1 183 0.78 145.5 50.91 5.00
66 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
67 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 5.00
68 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 5.00
69 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 5.00
70 INT13186 Positive_regulation of Il4 113 0.68 71.22 31.4 5.00
71 INT21900 Gene_expression of Mthfd1 150 0.75 69.47 27.03 5.00
72 INT17331 Positive_regulation of JUN 132 0.69 60.4 27.03 5.00
73 INT83797 Gene_expression of Bcl2l1 124 0.77 94.55 22.39 5.00
74 INT84732 Positive_regulation of Hand2 81 0.69 62.07 22 5.00
75 INT2006 Gene_expression of fc 104 0.34 64.91 19.08 5.00
76 INT11803 Positive_regulation of Il2 62 0.70 31.44 18.93 5.00
77 INT9220 Gene_expression of Ighg1 125 0.77 85.74 15.92 5.00
78 INT60197 Gene_expression of JUN 90 0.78 42.32 14.61 5.00
79 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36 5.00
80 INT100938 Positive_regulation of Il13 47 0.69 42.11 14.36 5.00
81 INT99780 Positive_regulation of Cxcl10 43 0.69 39.67 13.27 5.00
82 INT81629 Positive_regulation of Fas 58 0.70 59.63 12.94 5.00
83 INT31990 Positive_regulation of SOD1 124 0.69 67.79 12.52 5.00
84 INT27268 Localization of Gtf3a 71 0.21 56.93 12.51 5.00
85 INT112003 Localization of ROS1 94 0.73 66.32 12.16 5.00
86 INT81640 Positive_regulation of Gene_expression of Bcl2 106 0.69 84.58 11.63 5.00
87 INT58449 Binding of Mthfd1 47 0.47 22.02 10.29 5.00
88 INT10019 Binding of CD8A 57 0.36 31.49 10.08 5.00
89 INT3988 Positive_regulation of Gene_expression of IGHE 98 0.68 91.46 9.61 5.00
90 INT97439 Positive_regulation of Il5 46 0.60 25.6 9.47 5.00
91 INT3846 Positive_regulation of GSR 60 0.50 35.16 9.37 5.00
92 INT193663 Binding of Pain1 9 0.36 8.84 8.04 5.00
93 INT80220 Positive_regulation of Bcl2 71 0.58 57.73 7.86 5.00
94 INT99942 Positive_regulation of Fasl 37 0.68 32.61 6.92 5.00
95 INT160562 Localization of Cd4 49 0.71 27.58 6.78 5.00
96 INT53196 Binding of Cd4 44 0.47 27.28 5.85 5.00
97 INT84704 Positive_regulation of Nqo1 18 0.70 18.64 5.65 5.00
98 INT59891 Positive_regulation of GSTK1 46 0.67 17.66 5.33 5.00
99 INT201130 Localization of AES 31 0.63 25.45 5.12 5.00
100 INT68244 Positive_regulation of Ighg1 60 0.61 48.86 5.01 5.00
101 INT116150 Positive_regulation of Ddit3 26 0.67 22.58 5.01 5.00
102 INT284 Positive_regulation of Ggt6 18 0.67 13.56 4.62 5.00
103 INT188672 Positive_regulation of Tlr9 15 0.67 13.1 4.48 5.00
104 INT83794 Positive_regulation of Gene_expression of Bcl2l1 26 0.69 16.89 4.28 5.00
105 INT138698 Gene_expression of Txn1 15 0.77 11.71 4.24 5.00
106 INT83798 Negative_regulation of Gene_expression of Bcl2l1 28 0.58 20.26 4.21 5.00
107 INT57645 Gene_expression of GSTK1 54 0.62 21.05 4.2 5.00
108 INT172131 Positive_regulation of Gene_expression of fc 20 0.14 14.23 3.84 5.00
109 INT36799 Negative_regulation of Ighm 21 0.41 17.47 3.65 5.00
110 INT89966 Negative_regulation of Fas 26 0.58 24.83 3.5 5.00
111 INT130295 Gene_expression of Abcg2 21 0.75 9.75 3.42 5.00
112 INT20419 Negative_regulation of Gene_expression of MYC 19 0.57 9.7 3.29 5.00
113 INT81453 Positive_regulation of Gene_expression of JUN 18 0.50 9.39 3.23 5.00
114 INT157401 Gene_expression of Ctla4 21 0.65 15.43 3.2 5.00
115 INT140555 Positive_regulation of Localization of ROS1 29 0.55 23.82 3.14 5.00
116 INT93936 Gene_expression of Pgp 10 0.59 3.43 3.04 5.00
117 INT40315 Gene_expression of Abcc1 10 0.76 5.66 2.53 5.00
118 INT147349 Localization of Bcl2 13 0.65 7.83 2.31 5.00
119 INT133766 Negative_regulation of Fasl 11 0.56 11.28 2.27 5.00
120 INT101641 Gene_expression of Mcl1 25 0.54 20.3 2.23 5.00
121 INT117934 Gene_expression of Cd38 11 0.68 6.5 1.95 5.00
122 INT226637 Negative_regulation of Cxcr4 41 0.48 24.42 1.91 5.00
123 INT188678 Binding of Tlr7 14 0.32 6.6 1.89 5.00
124 INT56925 Negative_regulation of TSC1 54 0.52 63.39 1.87 5.00
125 INT59876 Regulation of fc 10 0.14 3.66 1.82 5.00
126 INT172961 Localization of Egf 26 0.71 16.74 1.81 5.00
127 INT61913 Binding of IgG2a 10 0.47 5.04 1.64 5.00
128 INT254298 Protein_catabolism of AES 6 0.55 9.79 1.43 5.00
129 INT60542 Positive_regulation of Gene_expression of GSTK1 11 0.39 6.21 1.13 5.00
130 INT201277 Gene_expression of Nhlrc1 5 0.14 2.05 1.1 5.00
131 INT19628 Regulation of Xdh 6 0.45 1.9 1.07 5.00
132 INT251837 Gene_expression of tb 3 0.06 2.94 0.97 5.00
133 INT130297 Positive_regulation of Gene_expression of Abcc1 3 0.56 1.06 0.97 5.00
134 INT135260 Negative_regulation of Pgp 4 0.42 1.13 0.95 5.00
135 INT193666 Gene_expression of Gpr83 2 0.14 0.92 0.91 5.00
136 INT112694 Negative_regulation of Positive_regulation of Fas 5 0.42 4.3 0.89 5.00
137 INT133323 Positive_regulation of Mod2 8 0.13 5.55 0.72 5.00
138 INT61910 Binding of Slc3a2 6 0.01 3 0.7 5.00
139 INT117416 Gene_expression of FAM20C 3 0.65 1.55 0.65 5.00
140 INT193665 Positive_regulation of Stat4 4 0.47 1.83 0.65 5.00
141 INT193672 Gene_expression of Prdx2 3 0.50 2.75 0.64 5.00
142 INT158329 Positive_regulation of Gene_expression of Mcl1 9 0.32 7.53 0.54 5.00
143 INT186290 Binding of Pvrl1 8 0.11 4.82 0.46 5.00
144 INT193674 Binding of Bcr 10 0.47 4.3 0.36 5.00
145 INT46843 Binding of Trf 10 0.47 3.45 0.35 5.00
146 INT126479 Regulation of Cxcr4 11 0.58 10.75 0.34 5.00
147 INT67140 Regulation of Mod2 3 0.41 2.54 0.34 5.00
148 INT193669 Gene_expression of Pvrl1 13 0.22 6.4 0.33 5.00
149 INT226647 Negative_regulation of Gene_expression of Cxcr4 4 0.40 3.31 0.31 5.00
150 INT181738 Positive_regulation of Localization of Gtf3a 4 0.02 2.46 0.25 5.00
151 INT193667 Regulation of Localization of Cd4 2 0.43 1.01 0.21 5.00
152 INT277802 Gene_expression of Rit1 3 0.35 4.59 0.21 5.00
153 INT187883 Gene_expression of Mod2 8 0.18 4.59 0.15 5.00
154 INT172476 Transcription of NFE2L2 7 0.69 2.47 0.11 5.00
155 INT193676 Positive_regulation of Gene_expression of Prdx2 2 0.06 1.31 0.09 5.00
156 INT193687 Gene_expression of TIMM8A 2 0.49 1.27 0.04 5.00
157 INT193686 Positive_regulation of Positive_regulation of GLRX2 1 0.04 0.79 0.04 5.00
158 INT193678 Regulation of Transcription of NFE2L2 1 0.06 0.69 0.04 5.00
159 INT193677 Positive_regulation of Gene_expression of TIMM8A 1 0.03 0.91 0.04 5.00
160 INT193685 Positive_regulation of GLRX2 2 0.24 1.11 0.04 5.00
161 INT193680 Negative_regulation of GLRX2 1 0.03 0.8 0.04 5.00
162 INT193675 Regulation of Gene_expression of Mod2 1 0.05 0.89 0.03 5.00
163 INT193688 Positive_regulation of Gene_expression of GLRX2 1 0.04 0.7 0.03 5.00
164 INT193683 Gene_expression of GLRX2 1 0.05 0.7 0.03 5.00
165 INT193671 Gene_expression of Txnrd2 1 0.01 1.02 0 5.00
166 INT165212 Regulation of Gene_expression of Cxcr4 4 0.48 1.33 0 5.00
167 INT193679 Positive_regulation of Gene_expression of FAM20C 1 0.49 1.18 0 5.00
168 INT347956 Negative_regulation of Regulation of Cxcr4 1 0.40 1.25 0 5.00
169 INT347954 Positive_regulation of Gene_expression of tb 1 0.04 0.38 0 5.00
170 INT347955 Localization of tb 1 0.06 0.37 0 5.00
171 INT277798 Negative_regulation of Gene_expression of Ms4a1 1 0.51 0.14 0 5.00
172 INT193670 Regulation of Csda 1 0.60 0.54 0 5.00
173 INT277795 Regulation of Binding of Ms4a1 2 0.24 0.67 0 5.00
174 INT226677 Regulation of Negative_regulation of Cxcr4 3 0.25 2.54 0 5.00
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