D:Back Pain

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pChart

Disease Term
Synonyms Ache Back, Aches Back, Back Ache, Back Aches, Back Pain With Radiation, Back Pain Without Radiation, Back Pains, Backache, Backaches, PAIN BACK, Pain Syndrome Vertebrogenic
Documents 1773
Hot Single Events 65
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Back Pain. They are ordered first by their relevance to Back Pain and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT141882 Binding of CD8A and HLA-A 1 0.32 0.9 0.29 79.80
2 INT340437 Binding of SERPINH1 and HLA-DRB4 1 0.00 2.26 0.84 73.12
3 INT300192 Gene_expression of APOA1 Positive_regulation of HSD11B1 1 0.16 1.08 0.08 23.28
4 INT300193 Binding of APOA1 and INSL4 1 0.01 2.17 0.18 18.08
5 INT340439 Binding of HLA-DMA and SUGT1 1 0.00 4.1 1.16 5.00
6 INT340440 Binding of HLA-B and BTG3 1 0.05 1.57 0.47 5.00
7 INT340438 Binding of HLA-DMA and MRAP 1 0.02 1.69 0.43 5.00
8 INT323926 MRM1 Positive_regulation of MRI1 1 0.04 0.44 0.26 5.00
9 INT239087 Binding of SST and Negative_regulation of Localization of GH1 1 0.19 0.36 0.24 5.00
10 INT247439 Binding of APOA1 and HSD11B1 3 0.32 5.01 0.03 5.00
11 INT300191 Binding of C1S and HSD11B1 1 0.13 1.75 0 5.00
12 INT300195 Binding of C1S and CHDH 1 0.23 2.51 0 5.00
13 INT313384 Binding of PDLIM5 and ZMYND10 1 0.04 0.82 0 5.00
14 INT300194 HSD11B1 Negative_regulation of CHDH 1 0.08 2.19 0 5.00
15 INT300199 PCSK9 Regulation of Gene_expression of LDLR 1 0.13 0.88 0 5.00
16 INT300197 Binding of APOA1 and C1S 1 0.39 3.56 0 5.00
17 INT300196 Binding of HSD11B1 and CHDH 1 0.07 4.01 0 5.00
18 INT300198 Positive_regulation of Binding of C1S and CHDH 1 0.31 1.63 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Back Pain. They are ordered first by their pain relevance and then by number of times they were reported in Back Pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT1976 Regulation of Gene_expression of Prl 80 0.62 20.19 36 100.00
2 INT45674 Regulation of Gene_expression of Serpina6 3 0.14 0.86 1.14 100.00
3 INT45675 Regulation of Gene_expression of Shbg 6 0.15 4.65 1.03 100.00
4 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 99.90
5 INT3602 Negative_regulation of Shbg 148 0.53 69.05 11.65 99.90
6 INT45672 Negative_regulation of Serpina6 5 0.43 1.66 2.08 99.90
7 INT156 Negative_regulation of Prl 542 0.59 131.97 192.24 99.90
8 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 99.86
9 INT37528 Positive_regulation of FAM49B 7 0.67 3.78 2.33 99.56
10 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 99.34
11 INT94859 Negative_regulation of Pde5a 67 0.43 33.66 10.28 99.00
12 INT528 Gene_expression of Prl 693 0.78 217.18 192.2 98.88
13 INT9832 Gene_expression of Shbg 96 0.75 56.71 12.19 98.88
14 INT45673 Gene_expression of Serpina6 10 0.53 3.47 3 98.88
15 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 98.42
16 INT123701 Negative_regulation of VDR 61 0.59 48.94 9.67 98.32
17 INT8959 Binding of Gnb5 17 0.40 31.38 5.1 98.16
18 INT167 Regulation of Ebp 3 0.44 0.77 1.03 97.28
19 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 97.16
20 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 97.16
21 INT957 Positive_regulation of GHRH 136 0.70 36.84 40.52 97.16
22 INT10059 Binding of CSH1 17 0.35 5.28 3.37 96.56
23 INT104731 Positive_regulation of NEFL 13 0.67 9.22 1.37 96.56
24 INT78284 Positive_regulation of PTPRC 40 0.49 27.17 3.45 96.24
25 INT20594 Regulation of Cym 1 0.01 0.19 0.14 95.96
26 INT156850 Binding of VDR 40 0.47 24.86 4.87 94.96
27 INT287118 Negative_regulation of Gene_expression of VDR 3 0.36 3.53 0.66 94.08
28 INT119700 Gene_expression of VDR 88 0.75 65.33 11.5 93.92
29 INT6511 Positive_regulation of AFP 76 0.70 70.15 7.28 93.28
30 INT252 Localization of GH1 529 0.80 227.4 122.05 92.72
31 INT425 Localization of PRL 455 0.81 189.64 144.8 92.72
32 INT10847 Gene_expression of LAMC2 39 0.75 27 12.09 92.72
33 INT10497 Gene_expression of TBR1 2 0.53 0.58 0.83 92.28
34 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 92.20
35 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 92.20
36 INT4498 Gene_expression of F2 83 0.65 57.4 10.8 92.16
37 INT26583 Positive_regulation of Cd4 40 0.54 21.96 4.83 91.92
38 INT1127 Negative_regulation of IGHG3 32 0.28 21.1 7.37 91.24
39 INT62386 Negative_regulation of Gene_expression of IGHG3 12 0.20 7.94 3.62 91.24
40 INT125840 Positive_regulation of Binding of Col2a1 1 0.43 1.21 0.45 91.16
41 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 90.52
42 INT119230 Negative_regulation of Htt 5 0.42 2.99 0.5 90.40
43 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 90.04
44 INT719 Negative_regulation of SGCG 96 0.57 47.91 30.22 89.84
45 INT102638 Regulation of VDR 21 0.44 9.92 2.54 89.60
46 INT124815 Binding of Col2a1 9 0.37 10.27 3.93 89.56
47 INT281392 Negative_regulation of TAB1 1 0.41 0.94 0.94 89.12
48 INT255232 Gene_expression of PRNT 1 0.65 1.64 0.13 88.32
49 INT9292 Positive_regulation of SGCG 93 0.67 35.13 23.48 85.76
50 INT163061 Negative_regulation of IDH2 1 0.37 0.4 0.19 85.72
51 INT163062 Negative_regulation of Binding of IDH2 1 0.37 0.4 0.19 85.72
52 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 85.36
53 INT140063 Binding of IDH2 2 0.32 1.35 0.19 85.20
54 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 85.12
55 INT47662 Localization of CHKB 34 0.81 22.63 5.14 84.48
56 INT130015 Positive_regulation of Localization of CHKB 3 0.48 1.72 0.39 84.48
57 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 84.20
58 INT725 Negative_regulation of IgG 62 0.41 37.21 8.16 83.72
59 INT2139 Negative_regulation of Cea 55 0.43 43.59 9.14 83.52
60 INT107042 Regulation of Ts1 3 0.44 1.68 0.22 81.48
61 INT107043 Positive_regulation of Phosphorylation of Ts1 1 0.19 0.5 0.12 81.48
62 INT107044 Phosphorylation of Ts1 1 0.31 0.5 0.12 81.48
63 INT1124 Negative_regulation of CD40LG 53 0.57 36.26 7 81.16
64 INT70756 Gene_expression of Adm 28 0.77 13.33 4.22 80.84
65 INT81757 Regulation of Gene_expression of Adm 6 0.44 2.86 1.16 80.84
66 INT76336 Negative_regulation of PDE5A 192 0.59 112.02 20.09 79.28
67 INT79477 Binding of HLA-DMA 19 0.26 13.78 3.47 78.32
68 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 77.20
69 INT10019 Binding of CD8A 57 0.36 31.49 10.08 77.16
70 INT69592 Positive_regulation of PSMD1 27 0.70 17.83 18.98 76.72
71 INT74254 Binding of PTPRC 16 0.36 8.37 1.27 76.32
72 INT9372 Negative_regulation of Lbp 86 0.58 46.54 41.71 75.00
73 INT1027 Gene_expression of Lbp 132 0.77 106.7 54.16 75.00
74 INT61316 Gene_expression of Coq10a 59 0.73 32.81 3.95 74.76
75 INT3795 Positive_regulation of Ighm 46 0.68 22.43 6.47 74.00
76 INT3797 Positive_regulation of Gene_expression of Ighm 16 0.47 9.4 2.01 74.00
77 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 73.88
78 INT3796 Gene_expression of Ighm 130 0.77 69.61 13.78 73.40
79 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 72.84
80 INT14301 Binding of CSF2 82 0.48 67.95 8.98 71.68
81 INT112968 Negative_regulation of Gnb5 5 0.34 7.79 1.81 71.48
82 INT1011 Positive_regulation of Ebp 3 0.50 1.59 0.86 71.36
83 INT21103 Gene_expression of Dbp 48 0.61 22.6 5.59 70.40
84 INT8640 Positive_regulation of HSD11B1 332 0.67 377.84 22.36 68.36
85 INT8637 Negative_regulation of Dbp 112 0.50 33.28 8.4 68.12
86 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 66.96
87 INT1829 Gene_expression of CFH 71 0.75 64.24 2.49 66.96
88 INT34585 Negative_regulation of Positive_regulation of HSD11B1 31 0.57 43.54 2.47 65.60
89 INT5841 Gene_expression of Vim 181 0.72 138.54 16.33 65.48
90 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 65.48
91 INT6810 Gene_expression of ENO2 70 0.78 54.8 8.35 65.48
92 INT574 Negative_regulation of C1S 9 0.47 11.25 1.41 65.00
93 INT49759 Negative_regulation of CETP 43 0.58 52 2.68 64.80
94 INT44816 Regulation of Serpina6 16 0.62 3.63 8.02 64.72
95 INT78710 Positive_regulation of GPKOW 2 0.01 2.06 1.59 64.24
96 INT677 Positive_regulation of CST3 20 0.67 17.47 6 63.24
97 INT52113 Gene_expression of CETP 25 0.69 25.71 0.99 62.52
98 INT6625 Negative_regulation of Pth 96 0.58 57.6 8.24 61.32
99 INT36263 Positive_regulation of CEL 53 0.69 34.88 12.87 60.96
100 INT341865 Negative_regulation of Nhlrc1 1 0.09 0.54 0.32 60.44
101 INT341866 Negative_regulation of Positive_regulation of Nhlrc1 1 0.09 0.54 0.32 60.44
102 INT78213 Gene_expression of Cspt 3 0.40 2.41 0.29 60.40
103 INT118102 Positive_regulation of Nhlrc1 4 0.40 1.19 1.21 60.20
104 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 57.08
105 INT660 Negative_regulation of REN 194 0.59 82.06 29.46 57.08
106 INT16184 Negative_regulation of CHKB 20 0.53 10.61 1.42 50.20
107 INT195984 Localization of LARS 3 0.42 0.93 0.53 50.00
108 INT145970 Negative_regulation of MSD 11 0.50 4.7 2.26 49.88
109 INT165645 Positive_regulation of Negative_regulation of Pde5a 3 0.37 1.58 0.74 42.64
110 INT443 Localization of POMC 1020 0.81 284.52 443.17 42.60
111 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 42.52
112 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 42.36
113 INT109110 Positive_regulation of Pde5a 29 0.63 11.16 16.65 41.84
114 INT84911 Gene_expression of SUGT1 43 0.11 19.85 4.54 36.00
115 INT130889 Regulation of KRT7 4 0.07 3.74 0.39 35.44
116 INT317061 Regulation of Gene_expression of KRT7 2 0.19 0.99 0.03 35.44
117 INT111477 Gene_expression of KRT7 90 0.74 86.76 4.07 33.60
118 INT323931 Regulation of MRM1 1 0.12 1.29 1.15 33.60
119 INT17237 Regulation of Esr1 74 0.43 49.09 17.25 32.96
120 INT38056 Localization of Crp 71 0.78 53.14 17.03 32.96
121 INT2038 Localization of Esr1 104 0.79 40.12 13.27 32.96
122 INT531 Gene_expression of GH1 376 0.75 193.45 46.24 31.44
123 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 31.16
124 INT20239 Regulation of APOA1 10 0.60 10.98 0.51 27.00
125 INT8669 Positive_regulation of Afp 66 0.70 58.21 7.67 26.72
126 INT30850 Gene_expression of MORF4 3 0.65 1.08 0.78 26.60
127 INT1735 Gene_expression of HSD11B1 199 0.75 257.87 11.5 26.56
128 INT21712 Positive_regulation of APOA1 32 0.67 21.64 2.64 25.60
129 INT41986 Positive_regulation of Gene_expression of HSD11B1 26 0.49 32.84 1.52 25.60
130 INT72672 Positive_regulation of Gene_expression of APOA1 4 0.67 3.81 0.89 25.60
131 INT72676 Gene_expression of APOA1 34 0.75 34.15 1.67 25.16
132 INT19396 Regulation of Rac1 66 0.53 37.41 30.01 25.00
133 INT22798 Regulation of Shbg 64 0.60 26.71 8.76 25.00
134 INT75682 Regulation of Chrna7 14 0.45 10.24 5.25 25.00
135 INT9730 Binding of LHB 4 0.35 2.38 1.19 25.00
136 INT27408 Phosphorylation of POMC 9 0.80 2.18 5.88 23.56
137 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 23.04
138 INT3206 Positive_regulation of Got1 39 0.69 19.36 17.02 21.36
139 INT14598 Gene_expression of Tpsab1 40 0.73 14.55 5.4 20.48
140 INT1020 Negative_regulation of BCHE 109 0.59 44.86 16.4 20.16
141 INT34590 Gene_expression of ALPP 199 0.75 89.85 15.1 19.32
142 INT22024 Negative_regulation of HBG1 45 0.58 26 6.8 17.56
143 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 17.08
144 INT46168 Positive_regulation of Sepp1 12 0.50 8.02 7.47 14.48
145 INT4605 Negative_regulation of Gene_expression of INS 220 0.58 139.66 10.75 7.88
146 INT323927 Gene_expression of MRM1 1 0.19 0.31 0.31 7.76
147 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 7.52
148 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 6.72
149 INT504 Gene_expression of GPT 42 0.75 27.54 3.99 6.60
150 INT182720 Binding of SHE 18 0.26 9.15 2.24 6.56
151 INT20622 Gene_expression of LDHA 107 0.76 77.97 16.3 5.60
152 INT300227 Positive_regulation of Binding of ABCA1 1 0.41 1.85 0.19 5.20
153 INT300220 Positive_regulation of Binding of ABCG1 1 0.34 1.96 0.19 5.20
154 INT158 Localization of Prl 2431 0.81 378.96 952.2 5.00
155 INT1045 Localization of LH 1211 0.81 87.04 456.25 5.00
156 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
157 INT159 Negative_regulation of Localization of Prl 416 0.59 55.34 171.8 5.00
158 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
159 INT1047 Negative_regulation of LH 314 0.59 53.71 135.89 5.00
160 INT695 Binding of POMC 304 0.48 56.66 126.85 5.00
161 INT7395 Localization of GNRH1 399 0.81 62.88 117.68 5.00
162 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 5.00
163 INT2123 Positive_regulation of Gnrh1 209 0.70 24.2 68.97 5.00
164 INT1046 Gene_expression of LH 180 0.77 29.75 66.87 5.00
165 INT253 Regulation of PRL 184 0.62 47.27 65.79 5.00
166 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9 5.00
167 INT9196 Gene_expression of PTGS1 215 0.77 96.99 60.5 5.00
168 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
169 INT647 Gene_expression of SGCG 211 0.75 78.46 55.82 5.00
170 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 5.00
171 INT249 Localization of GHRH 215 0.80 78.02 51.87 5.00
172 INT5118 Regulation of SST 97 0.62 34.35 51.74 5.00
173 INT2197 Gene_expression of Gnrh1 184 0.78 40.04 50.57 5.00
174 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
175 INT22454 Regulation of Crp 213 0.62 160.67 49.24 5.00
176 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 5.00
177 INT2774 Binding of Crp 241 0.48 195.89 44.39 5.00
178 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 5.00
179 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 5.00
180 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 5.00
181 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
182 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 5.00
183 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67 5.00
184 INT11325 Gene_expression of HLA-E 209 0.76 98.05 33.72 5.00
185 INT248 Positive_regulation of Localization of GH1 137 0.69 49.25 32.92 5.00
186 INT691 Binding of SST 67 0.48 24.66 32.67 5.00
187 INT985 Negative_regulation of GH1 213 0.57 89.53 32.39 5.00
188 INT132161 Gene_expression of MTX1 48 0.58 26.55 32.32 5.00
189 INT37296 Binding of Esr1 117 0.43 62.51 27.33 5.00
190 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 5.00
191 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 5.00
192 INT79395 Gene_expression of Twist1 193 0.77 100.06 26.34 5.00
193 INT7394 Positive_regulation of Localization of GNRH1 67 0.69 7.22 25.29 5.00
194 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77 5.00
195 INT58288 Positive_regulation of Gene_expression of Crp 83 0.61 82.23 23.7 5.00
196 INT1221 Regulation of SGCG 65 0.60 24.21 22.94 5.00
197 INT71047 Gene_expression of CYP19A1 122 0.78 68.78 22.21 5.00
198 INT16303 Negative_regulation of Localization of GH1 89 0.59 37.31 22.15 5.00
199 INT955 Gene_expression of GHRH 126 0.78 59.91 20.74 5.00
200 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
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