D:Basal Cell Carcinoma

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Disease Term
Synonyms Basal Cell Carcinomas, BASAL CELL EPITHELIOMA, Basal Cell Epitheliomas, Carcinoma Basal Cell Pigmented, Carcinomas Basal Cell, Epithelioma Basal Cell, EPITHELIOMAS BASAL CELL, Rodent Ulcer, RODENT ULCERS, Ulcer Rodent, ULCERS RODENT
Documents 71
Hot Single Events 55
Hot Interactions 4

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Basal Cell Carcinoma. They are ordered first by their relevance to Basal Cell Carcinoma and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT345337 Binding of TP53 and BCC1 1 0.11 1.05 0 100.00
2 INT241588 Binding of FAS and Fas 1 0.05 2.34 0 98.72
3 INT256632 Binding of PTCH1 and Jkamp 1 0.00 2.32 0 91.36
4 INT279145 Binding of VHL and RNF139 1 0.30 1.87 0 89.12
5 INT256629 Binding of Ptch1 and Shh 7 0.42 4.22 0.19 57.72
6 INT279144 RNF139 Regulation of TSN 1 0.24 3.47 0 50.80
7 INT279143 Binding of TSN and RNF139 1 0.31 0.83 0 43.56
8 INT190052 Binding of Cdx2 and Ebp 1 0.08 0.82 0.24 5.00
9 INT190045 Binding of Ebp and Scrib 1 0.10 0.79 0.22 5.00
10 INT276228 Nrtim1 Positive_regulation of PPARG 1 0.01 2.18 0.14 5.00
11 INT256544 Pten Negative_regulation of Akt1 1 0.05 1.07 0.11 5.00
12 INT256545 Positive_regulation of Pten Negative_regulation of Akt1 1 0.05 1.07 0.11 5.00
13 INT232917 Binding of KRT8 and KRT19 2 0.16 1.04 0.08 5.00
14 INT256548 Regulation of Cd320 Positive_regulation of Ppara 1 0.28 0.43 0.05 5.00
15 INT232914 Binding of KRT2 and KRT7 1 0.15 0.63 0.05 5.00
16 INT190044 Binding of Msh2 and Msh6 2 0.32 0.77 0.05 5.00
17 INT256551 Cd320 Regulation of Cd320 Positive_regulation of Ppara 1 0.31 0.43 0.05 5.00
18 INT232916 Binding of KRT2 and KRT19 1 0.21 0.62 0.05 5.00
19 INT232907 Binding of KRT7 and KRT8 1 0.09 0.63 0.05 5.00
20 INT256547 Cd320 Positive_regulation of Ppara 1 0.47 0.43 0.05 5.00
21 INT190050 Binding of Msh2 and Pms2 2 0.32 0.49 0.04 5.00
22 INT190046 Binding of Msh3 and Pms2 2 0.25 0.5 0.04 5.00
23 INT256549 Binding of Pten and Mtor 1 0.00 1.02 0.03 5.00
24 INT190061 Binding of MLH1 and Mlh1 1 0.01 0.92 0 5.00
25 INT232918 Binding of KRT2 and KRT8 1 0.17 0.59 0 5.00
26 INT256543 Fabp4 Positive_regulation of Ppara 1 0.29 0 0 5.00
27 INT232912 Binding of KRT4 and KRT13 1 0.07 0.06 0 5.00
28 INT232910 Binding of KRT12 and KRT76 1 0.39 0.2 0 5.00
29 INT232911 Binding of KRT18 and PLAT 1 0.05 1.3 0 5.00
30 INT190049 Binding of Mlh1 and Msh3 1 0.24 0.22 0 5.00
31 INT190048 Binding of Mlh1 and Msh2 1 0.31 0.22 0 5.00
32 INT232915 Binding of KRT8 and PLAT 1 0.04 1.3 0 5.00
33 INT232909 Binding of KRT1 and KRT9 1 0.16 0.5 0 5.00
34 INT256546 Fabp5 Positive_regulation of Ppara 1 0.24 0 0 5.00
35 INT190062 Binding of MLH1 and Msh2 1 0.01 0.91 0 5.00
36 INT232913 Binding of KRT3 and NBPF14 1 0.01 0.21 0 5.00
37 INT190047 Binding of Msh2 and Msh3 1 0.24 0.23 0 5.00
38 INT232908 Binding of KRT19 and PLAT 1 0.05 1.31 0 5.00
39 INT232906 Binding of KRT1 and KRT10 1 0.18 0.51 0 5.00
40 INT200724 HDAC9 Positive_regulation of TP53 1 0.36 0.27 0 5.00
41 INT190051 Binding of Ebp and Mrc1 1 0.04 0.63 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Basal Cell Carcinoma. They are ordered first by their pain relevance and then by number of times they were reported in Basal Cell Carcinoma. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT180264 Positive_regulation of BCC1 11 0.59 12.81 0.2 100.00
2 INT284765 Gene_expression of BCC1 22 0.56 29.32 0.14 100.00
3 INT180265 Localization of BCC1 7 0.65 9.48 0.15 100.00
4 INT345339 Positive_regulation of Localization of BCC1 1 0.11 0.89 0 100.00
5 INT153345 Gene_expression of CELP 2 0.65 3.62 0.19 100.00
6 INT284763 Positive_regulation of Gene_expression of CELP 1 0.17 1.51 0 100.00
7 INT284766 Negative_regulation of Gene_expression of CELP 1 0.15 2.04 0 100.00
8 INT77620 Gene_expression of Fas 146 0.78 72.4 16.61 99.84
9 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 99.84
10 INT88014 Positive_regulation of Gene_expression of Fas 29 0.50 14.84 7.47 99.84
11 INT135299 Binding of PTCH1 10 0.48 12.16 0.84 99.76
12 INT21737 Binding of MC1R 129 0.48 45.45 56.54 99.76
13 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 99.72
14 INT139077 Negative_regulation of Ptch1 5 0.56 5.22 1.29 99.56
15 INT113517 Binding of Fas 16 0.37 15.86 4.62 98.72
16 INT80033 Binding of FAS 37 0.48 41.19 5.67 98.62
17 INT57748 Positive_regulation of Gene_expression of TP53 85 0.69 79.55 7.49 97.80
18 INT225959 Gene_expression of KRT15 7 0.48 2.01 0 97.72
19 INT284762 Positive_regulation of Gene_expression of BCC1 1 0.42 2.94 0 97.48
20 INT227017 Gene_expression of KRT17 2 0.45 14.84 0.41 97.44
21 INT85084 Gene_expression of KRT19 66 0.73 42.56 1.82 97.44
22 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 96.32
23 INT84546 Positive_regulation of Ppara 481 0.70 334.21 83.45 96.16
24 INT195206 Binding of BCC1 15 0.41 21.3 0.62 95.32
25 INT256628 Regulation of Nsdhl 2 0.11 4.12 0.43 94.32
26 INT67613 Positive_regulation of PPARG 94 0.70 69.15 34.38 94.12
27 INT57749 Negative_regulation of Gene_expression of TP53 39 0.56 36.79 4.45 93.76
28 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 92.08
29 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62 91.60
30 INT122039 Positive_regulation of Gene_expression of Ppara 144 0.68 113.55 28.55 91.48
31 INT115386 Gene_expression of Ppara 779 0.77 549.99 128.36 91.48
32 INT279147 Negative_regulation of RNF139 1 0.53 5.41 0.06 91.20
33 INT183055 Gene_expression of PTCH1 10 0.77 15.54 0.26 91.04
34 INT244704 Gene_expression of ARG1 65 0.75 37.74 1.9 91.04
35 INT233008 Gene_expression of KRT75 1 0.56 1.07 0.11 89.52
36 INT227013 Positive_regulation of KRT17 2 0.27 2.4 0 89.52
37 INT205973 Binding of SHH 3 0.35 1.03 0.07 89.24
38 INT213515 Binding of Shh 8 0.37 1.92 0.08 88.60
39 INT55135 Positive_regulation of Gene_expression of PTGS2 137 0.70 80.32 38.46 87.44
40 INT260448 Gene_expression of RXFP2 1 0.12 1.35 0.09 87.44
41 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 87.36
42 INT135720 Gene_expression of War 7 0.34 3.99 0.28 87.20
43 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 86.80
44 INT65919 Gene_expression of Ptch1 11 0.75 6.47 0.56 86.60
45 INT188406 Binding of Fasl 19 0.44 24.67 3.17 86.56
46 INT142416 Binding of Ptch1 6 0.34 4.92 0.74 86.52
47 INT39153 Positive_regulation of PTGS2 182 0.70 96.16 60.6 86.24
48 INT100275 Gene_expression of TBL1XR1 19 0.25 6.99 1.33 82.84
49 INT100277 Positive_regulation of Gene_expression of TBL1XR1 5 0.19 1.9 0.25 82.84
50 INT122041 Binding of Ppara 308 0.48 189.17 51.48 82.64
51 INT216873 Binding of TBL1XR1 3 0.36 4.44 0.4 82.40
52 INT73625 Gene_expression of PPARG 108 0.78 104.85 21.42 81.28
53 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 81.28
54 INT73626 Positive_regulation of Gene_expression of PPARG 22 0.70 18.82 4.4 81.28
55 INT239083 Binding of PPY 9 0.32 7.59 2.9 80.80
56 INT176498 Positive_regulation of Gene_expression of KLK5 2 0.31 0.14 0 79.96
57 INT232944 Transcription of KRT75 1 0.43 0.59 0.18 79.68
58 INT176496 Gene_expression of KLK5 4 0.41 0.22 0 79.68
59 INT146179 Gene_expression of KRT6A 23 0.75 9.39 0.52 77.96
60 INT232990 Localization of KRT6A 1 0.43 0.37 0 77.96
61 INT232985 Positive_regulation of Localization of KRT6A 1 0.29 0.37 0 77.96
62 INT86639 Gene_expression of KRT16 19 0.68 12.44 7.79 77.88
63 INT232999 Positive_regulation of Localization of KRT16 1 0.32 0.37 0 77.84
64 INT232956 Localization of KRT16 1 0.47 0.37 0 77.84
65 INT256631 Positive_regulation of PTCH1 2 0.13 1.97 0 77.72
66 INT176497 Regulation of KLK5 2 0.28 0.45 0.22 76.28
67 INT145594 Gene_expression of Mtx1 64 0.57 35.33 30.35 75.32
68 INT227515 Regulation of Gene_expression of Mtx1 5 0.38 4.34 3.24 75.32
69 INT232989 Gene_expression of KRT71 1 0.46 0.45 0.17 74.96
70 INT206467 Gene_expression of IARS 11 0.33 6.65 0.93 74.52
71 INT279150 Gene_expression of RNF139 1 0.71 11.45 0 72.36
72 INT279156 Gene_expression of TSN 1 0.64 5.67 0 72.36
73 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 72.32
74 INT194462 Localization of Ppara 94 0.78 68.33 12.09 71.20
75 INT52264 Gene_expression of IK 180 0.77 90.87 51.87 70.64
76 INT165841 Gene_expression of BPIFA4P 17 0.65 6.48 2.38 70.64
77 INT232987 Gene_expression of KRT85 1 0.10 1.2 0.11 70.16
78 INT256626 Regulation of Ptch2 1 0.28 1.11 0 69.48
79 INT60585 Regulation of TP53 59 0.59 54.55 5.21 68.08
80 INT232995 Negative_regulation of Gene_expression of KRT15 1 0.32 0.37 0 67.44
81 INT208561 Gene_expression of Shh 51 0.78 9.57 1.77 66.60
82 INT232799 Regulation of Gene_expression of Shh 3 0.27 1.04 0.16 66.60
83 INT233004 Localization of KRT17 1 0.36 0.19 0 63.68
84 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 62.88
85 INT179307 Regulation of GNAS 7 0.01 1.93 0.05 62.64
86 INT256627 Regulation of Negative_regulation of Ptch2 1 0.32 1.33 0 62.24
87 INT200219 Positive_regulation of VHL 18 0.50 15.38 0.67 62.08
88 INT68094 Negative_regulation of SERPINB3 12 0.43 10.55 1.49 61.36
89 INT256625 Negative_regulation of Ptch2 1 0.42 1.27 0 60.80
90 INT218956 Regulation of RNF123 3 0.01 1.06 0.03 60.68
91 INT232951 Gene_expression of KRT81 1 0.39 0.31 0.11 59.84
92 INT62169 Positive_regulation of MC1R 72 0.69 14.56 27.52 59.36
93 INT97797 Localization of TLR4 18 0.77 13.78 6 52.24
94 INT236786 Positive_regulation of Localization of TLR4 2 0.45 1.89 0.57 52.24
95 INT279159 Regulation of RNF139 1 0.56 2.98 0 51.12
96 INT117220 Positive_regulation of TLR4 64 0.69 53.61 17.33 49.68
97 INT232955 Gene_expression of KRT38 1 0.47 0.12 0.13 47.24
98 INT133648 Regulation of HDAC9 14 0.60 10.01 2.18 46.60
99 INT106382 Gene_expression of NME1 13 0.66 5.18 0.56 45.92
100 INT200733 Gene_expression of METTL1 1 0.04 1.03 0 45.92
101 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9 45.40
102 INT279151 Regulation of TSN 1 0.37 3.34 0 44.12
103 INT200735 Regulation of NME1 1 0.60 1.03 0 43.36
104 INT200739 Regulation of METTL1 1 0.01 1.03 0 42.96
105 INT153257 Regulation of Ptch1 6 0.36 5.92 0.67 42.60
106 INT232922 Gene_expression of Krt71 1 0.65 0 0 40.16
107 INT232921 Gene_expression of Krt6b 2 0.65 1.5 0 40.16
108 INT279152 Positive_regulation of RNF139 1 0.46 1.29 0 39.96
109 INT175423 Positive_regulation of TSC1 25 0.36 21.81 0.45 34.68
110 INT50670 Gene_expression of CPOX 763 0.76 442.13 195.02 31.20
111 INT86640 Positive_regulation of Gene_expression of KRT16 5 0.61 2.5 2.99 27.72
112 INT189228 Positive_regulation of KRT16 5 0.44 1.89 0.41 27.72
113 INT146180 Positive_regulation of Gene_expression of KRT6A 2 0.49 1.43 0.16 27.72
114 INT232981 Positive_regulation of Gene_expression of KRT17 1 0.25 1.06 0.05 27.72
115 INT232997 Positive_regulation of KRT6A 1 0.40 0.82 0 27.72
116 INT284764 Positive_regulation of Transcription of BCC1 1 0.42 1.58 0 26.88
117 INT284767 Transcription of BCC1 1 0.57 1.58 0 26.88
118 INT232954 Binding of KRT15 1 0.17 0 0 26.88
119 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 22.44
120 INT232964 Gene_expression of KRT28 4 0.48 3.88 0.13 22.44
121 INT232996 Gene_expression of KRT27 1 0.44 0 0.07 22.44
122 INT232974 Gene_expression of KRT25 1 0.36 0 0.06 22.44
123 INT4756 Positive_regulation of Nrtim1 37 0.33 14.6 24.12 17.72
124 INT92139 Binding of MLH1 12 0.42 15.62 1 17.28
125 INT176501 Binding of KLK5 2 0.23 0.17 0.14 14.72
126 INT172173 Protein_catabolism of TNF 16 0.96 9.95 3.79 13.44
127 INT58755 Binding of PAM 6 0.34 3.09 0.97 12.92
128 INT232977 Gene_expression of KRT77 1 0.75 3.41 0 11.84
129 INT197167 Positive_regulation of Localization of Ppara 18 0.67 9.51 1.21 11.52
130 INT233006 Binding of KRT17 1 0.28 0.8 0.04 11.44
131 INT174240 Negative_regulation of TYMS 12 0.57 6.35 1.82 9.36
132 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 7.52
133 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
134 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
135 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 5.00
136 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
137 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
138 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
139 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
140 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
141 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
142 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 5.00
143 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 5.00
144 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
145 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
146 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18 5.00
147 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 5.00
148 INT48232 Gene_expression of MMP1 245 0.78 96.31 57.72 5.00
149 INT96914 Phosphorylation of Mapk14 168 0.82 108.46 53.32 5.00
150 INT62543 Gene_expression of Icam1 231 0.78 187.58 52.71 5.00
151 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 5.00
152 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 5.00
153 INT103094 Binding of PPARA 308 0.47 177.26 34.75 5.00
154 INT666 Gene_expression of Jun 124 0.78 54.61 33.67 5.00
155 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
156 INT81530 Gene_expression of Nfkb1 93 0.78 48.58 32.58 5.00
157 INT62830 Gene_expression of VCAM1 149 0.78 125.23 32.4 5.00
158 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7 5.00
159 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 5.00
160 INT115385 Negative_regulation of Ppara 154 0.58 129.05 27.58 5.00
161 INT79395 Gene_expression of Twist1 193 0.77 100.06 26.34 5.00
162 INT14733 Positive_regulation of Gene_expression of TGFB1 71 0.69 49.89 22.2 5.00
163 INT101517 Negative_regulation of PPARA 168 0.57 112.24 21.41 5.00
164 INT11346 Binding of Mtx1 39 0.41 24.88 21.21 5.00
165 INT96269 Positive_regulation of Mcpt1 71 0.61 52.38 20.4 5.00
166 INT93663 Positive_regulation of MMP1 72 0.67 33.38 19.86 5.00
167 INT70145 Gene_expression of Trav6-3 136 0.76 69.6 18.05 5.00
168 INT111531 Negative_regulation of Phosphorylation of Mapk14 37 0.50 20 17.68 5.00
169 INT62546 Positive_regulation of Gene_expression of Icam1 60 0.70 59.52 16.9 5.00
170 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 5.00
171 INT171666 Regulation of GOPC 117 0.39 40.41 15.47 5.00
172 INT81627 Gene_expression of Fas 120 0.78 115.51 15.36 5.00
173 INT12087 Regulation of Localization of TNF 44 0.62 28.71 15.17 5.00
174 INT79227 Negative_regulation of Gene_expression of Icam1 45 0.59 41.65 14.97 5.00
175 INT103096 Regulation of PPARA 113 0.60 62.47 14.57 5.00
176 INT109511 Gene_expression of Bax 133 0.78 113.22 14.36 5.00
177 INT92823 Positive_regulation of Gene_expression of MMP1 65 0.68 25.69 14.31 5.00
178 INT1758 Positive_regulation of Gene_expression of TIMP1 62 0.69 31.72 13.98 5.00
179 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 5.00
180 INT122037 Regulation of Ppara 93 0.62 56.28 12.89 5.00
181 INT114274 Gene_expression of Rxra 67 0.70 36.77 12.5 5.00
182 INT81640 Positive_regulation of Gene_expression of Bcl2 106 0.69 84.58 11.63 5.00
183 INT10874 Negative_regulation of Twist1 89 0.50 36.84 11.32 5.00
184 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 5.00
185 INT1108 Gene_expression of PPY 58 0.75 36.57 10.76 5.00
186 INT151168 Gene_expression of Pten 60 0.78 35.63 10.54 5.00
187 INT173159 Localization of PPARA 96 0.74 64.55 10.26 5.00
188 INT3180 Positive_regulation of PPY 39 0.63 25.57 10.15 5.00
189 INT73504 Binding of CD28 35 0.45 15.99 10.04 5.00
190 INT101105 Positive_regulation of FUT1 62 0.30 55.96 9.28 5.00
191 INT89677 Gene_expression of PRKG1 38 0.78 13.98 8.56 5.00
192 INT43820 Positive_regulation of Twist1 75 0.59 42.15 8.47 5.00
193 INT13085 Positive_regulation of ACE 50 0.70 44.2 8.31 5.00
194 INT36798 Gene_expression of Mki67 178 0.77 132 8.24 5.00
195 INT24232 Localization of Mtx1 24 0.65 8.06 7.99 5.00
196 INT53487 Gene_expression of TSC1 81 0.58 77.71 7.94 5.00
197 INT80220 Positive_regulation of Bcl2 71 0.58 57.73 7.86 5.00
198 INT181817 Negative_regulation of Gene_expression of Ppara 58 0.58 43.24 7.67 5.00
199 INT11652 Gene_expression of Rara 30 0.58 24.96 6.98 5.00
200 INT125143 Gene_expression of EPHB2 40 0.71 13.27 6.97 5.00
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