D:Basal Cell Neoplasms

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Disease Term
Synonyms Basal Cell Cancer, Basal Cell Cancers, Basal Cell Neoplasm, Cancer Basal Cell, Cancers Basal Cell, CELL CANCER BASAL, Cell Cancers Basal, CELL NEOPLASM BASAL, CELL NEOPLASMS BASAL, Neoplasm Basal Cell
Documents 7
Hot Single Events 13
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Basal Cell Neoplasms. They are ordered first by their relevance to Basal Cell Neoplasms and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT262751 Binding of PTCH1 and SMO 1 0.25 1.29 0.1 77.28
2 INT306745 Binding of Il12a and IL23A 1 0.10 3.25 1.56 5.00
3 INT306732 Il17a Positive_regulation of Gene_expression of Il2 1 0.09 1.07 0.46 5.00
4 INT306731 Il22 Positive_regulation of Gene_expression of Il2 1 0.12 1.07 0.46 5.00
5 INT262760 Binding of TEP1 and CD163L1 1 0.00 1.65 0.37 5.00
6 INT306714 IL23A Positive_regulation of TNF 1 0.29 0.5 0.21 5.00
7 INT306746 Il12a Positive_regulation of TNF 1 0.24 0.5 0.21 5.00
8 INT306744 IL23A Positive_regulation of Il12a 1 0.13 0.59 0.2 5.00
9 INT256629 Binding of Ptch1 and Shh 7 0.42 4.22 0.19 5.00
10 INT306747 IL23A Positive_regulation of Il17a 1 0.05 0.51 0.16 5.00
11 INT262758 MRGPRF Positive_regulation of Transcription of NFE2L3 1 0.01 1.25 0.09 5.00
12 INT262754 MRGPRF Positive_regulation of NFE2L3 1 0.01 1.24 0.09 5.00
13 INT262755 MRGPRF Positive_regulation of NFE2L2 1 0.18 1.24 0.09 5.00
14 INT262781 Birc5 Regulation of TEP1 1 0.00 0.49 0.05 5.00
15 INT262780 Birc5 Regulation of CD163L1 1 0.00 0.49 0.05 5.00
16 INT262757 SMO Positive_regulation of Regulation of GLI1 1 0.34 0.6 0.04 5.00
17 INT262750 GLYR1 Positive_regulation of THBS1 1 0.01 0.99 0 5.00
18 INT262759 PIK3CG Positive_regulation of MTOR 1 0.38 0.54 0 5.00
19 INT176131 Binding of AKT1 and PIK3CG 2 0.15 1.08 0 5.00
20 INT262752 IGHA1 Positive_regulation of IGKV2D-19 1 0.00 1.39 0 5.00
21 INT256632 Binding of PTCH1 and Jkamp 1 0.00 2.32 0 5.00
22 INT262756 STAT3 Positive_regulation of NFE2L2 1 0.31 1.55 0 5.00
23 INT262753 Binding of MTOR and PIK3CG 1 0.20 0.82 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Basal Cell Neoplasms. They are ordered first by their pain relevance and then by number of times they were reported in Basal Cell Neoplasms. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT83735 Gene_expression of Foxm1 41 0.77 22.9 5.07 99.44
2 INT249785 Positive_regulation of Gene_expression of Foxm1 13 0.69 4.71 0.36 99.44
3 INT262770 Binding of SLC25A16 1 0.05 1.04 0 95.72
4 INT116464 Negative_regulation of Birc5 53 0.59 45.4 4.91 94.52
5 INT256921 Regulation of Top2a 1 0.21 1.28 0 94.28
6 INT9908 Negative_regulation of IAPP 29 0.57 19.37 2.12 92.60
7 INT140296 Negative_regulation of XIAP 9 0.45 13.61 1.37 92.60
8 INT121834 Gene_expression of IAPP 24 0.66 20.96 0.26 91.32
9 INT220330 Positive_regulation of Gene_expression of IAPP 3 0.43 2.12 0 91.32
10 INT235686 Gene_expression of Top2a 5 0.60 4.34 0 85.72
11 INT182318 Regulation of Birc5 25 0.60 23.58 2.29 84.64
12 INT135299 Binding of PTCH1 10 0.48 12.16 0.84 82.88
13 INT256916 Regulation of Gene_expression of Top2a 1 0.47 1.2 0 80.52
14 INT262777 Localization of SMO 1 0.59 0.6 0.04 79.68
15 INT50335 Positive_regulation of Foxm1 20 0.69 5.11 2.81 77.12
16 INT262749 Negative_regulation of Transcription of Birc5 1 0.02 1.37 0.07 76.36
17 INT182314 Transcription of Birc5 4 0.69 2.69 0.37 76.04
18 INT205969 Regulation of GLI1 4 0.41 3.09 0.04 74.48
19 INT262772 Binding of SMO 1 0.27 0.59 0.05 67.36
20 INT70138 Positive_regulation of Ccnb1 7 0.41 4.31 1.26 56.20
21 INT116465 Gene_expression of Birc5 241 0.78 192.31 15.32 48.84
22 INT116463 Negative_regulation of Gene_expression of Birc5 40 0.59 33.99 2.74 48.84
23 INT256905 Positive_regulation of Ccne2 1 0.52 1.08 0 43.36
24 INT256909 Positive_regulation of Mcm7 1 0.41 1.08 0 43.36
25 INT116194 Gene_expression of Casp8 14 0.75 14.61 2.13 34.44
26 INT89963 Regulation of Fas 15 0.59 8.25 4.32 30.60
27 INT89966 Negative_regulation of Fas 26 0.58 24.83 3.5 30.60
28 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 24.16
29 INT256915 Regulation of Ccne2 1 0.34 0.98 0 24.16
30 INT81627 Gene_expression of Fas 120 0.78 115.51 15.36 19.84
31 INT256908 Regulation of ltnr2 1 0.00 0.43 0 17.36
32 INT136503 Negative_regulation of KDR 46 0.48 43.1 1.86 17.20
33 INT98784 Gene_expression of Ccnb1 11 0.59 4.53 0.75 12.72
34 INT249788 Positive_regulation of Gene_expression of Ccnb1 2 0.44 0.51 0 12.72
35 INT256906 Regulation of Gene_expression of Ccnb1 1 0.17 0.39 0 12.72
36 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 10.08
37 INT256912 Transcription of Ifnar2 1 0.55 1.04 0 8.80
38 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65 6.80
39 INT93356 Negative_regulation of Gene_expression of Trp53 28 0.53 20.61 0.8 6.80
40 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
41 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
42 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
43 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
44 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
45 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
46 INT118381 Gene_expression of Il17a 405 0.76 306.97 112.06 5.00
47 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
48 INT60691 Gene_expression of Il12a 331 0.78 208.03 75.96 5.00
49 INT11807 Gene_expression of Il2 266 0.78 112 64.97 5.00
50 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53 5.00
51 INT69036 Gene_expression of IL18 99 0.77 77.92 25.95 5.00
52 INT150022 Positive_regulation of Il17a 69 0.64 70.04 21.87 5.00
53 INT11804 Positive_regulation of Gene_expression of Il2 70 0.70 33 21.63 5.00
54 INT160564 Gene_expression of Il22 64 0.55 59.29 20.9 5.00
55 INT60690 Positive_regulation of Gene_expression of Il12a 69 0.63 41.41 20.85 5.00
56 INT14701 Negative_regulation of IFNA1 118 0.54 84.19 20.08 5.00
57 INT88949 Positive_regulation of Il12a 79 0.60 47.68 19.98 5.00
58 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61 5.00
59 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44 5.00
60 INT9656 Regulation of Gene_expression of Il6 57 0.62 33.3 17.71 5.00
61 INT168263 Gene_expression of IL23A 57 0.58 47.1 17.67 5.00
62 INT34057 Negative_regulation of Gene_expression of IFNA1 65 0.58 43.46 17.25 5.00
63 INT93948 Negative_regulation of Gene_expression of Il12a 48 0.55 27.77 16.87 5.00
64 INT103757 Negative_regulation of Il12a 37 0.55 21.62 16.38 5.00
65 INT52107 Transcription of IL8 63 0.72 41.66 16.06 5.00
66 INT161515 Positive_regulation of Gene_expression of Il17a 50 0.64 41.52 13.82 5.00
67 INT20378 Localization of Hand1 53 0.71 41.96 13.31 5.00
68 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83 5.00
69 INT94464 Negative_regulation of Hand1 44 0.41 31.5 12.39 5.00
70 INT87239 Localization of Il12a 51 0.75 31.95 12.05 5.00
71 INT111476 Gene_expression of TP63 88 0.76 61.08 11.64 5.00
72 INT95565 Positive_regulation of IL12A 47 0.56 33.96 10.16 5.00
73 INT107307 Transcription of IFNA1 30 0.52 18.16 9.61 5.00
74 INT226463 Positive_regulation of IL23A 23 0.45 21.58 9.18 5.00
75 INT53487 Gene_expression of TSC1 81 0.58 77.71 7.94 5.00
76 INT224648 Gene_expression of Il21 15 0.39 18.71 7.47 5.00
77 INT228469 Negative_regulation of Il17a 19 0.54 18.76 6.43 5.00
78 INT93359 Positive_regulation of Trp53 90 0.70 69.77 6.24 5.00
79 INT106189 Regulation of Il12a 18 0.44 12.4 5.3 5.00
80 INT246031 Gene_expression of IL22 10 0.40 9.48 5.11 5.00
81 INT175312 Positive_regulation of Gene_expression of IL23A 17 0.45 14.8 5.05 5.00
82 INT98251 Binding of IL12A 20 0.37 16.03 4.51 5.00
83 INT75136 Binding of Akt1 27 0.27 8.81 4.15 5.00
84 INT182311 Positive_regulation of Birc5 26 0.67 25.32 4.08 5.00
85 INT296054 Positive_regulation of Il22 13 0.33 17.97 4.06 5.00
86 INT235510 Binding of Il17a 14 0.34 10.67 3.99 5.00
87 INT86919 Negative_regulation of PIK3CG 40 0.57 21.16 3.97 5.00
88 INT71602 Negative_regulation of Trp53 84 0.59 67.77 3.68 5.00
89 INT285489 Positive_regulation of Gene_expression of Il22 9 0.32 10.97 3.63 5.00
90 INT174160 Binding of Il12a 19 0.24 12.61 3.4 5.00
91 INT12844 Binding of TP63 15 0.47 10.57 3.38 5.00
92 INT184060 Negative_regulation of Stat1 28 0.58 17.44 3.19 5.00
93 INT250884 Binding of IL23A 5 0.19 7.17 3.17 5.00
94 INT41721 Negative_regulation of MTOR 40 0.58 32.49 2.83 5.00
95 INT114181 Negative_regulation of Positive_regulation of Il12a 7 0.34 3.65 2.82 5.00
96 INT89401 Negative_regulation of Phosphorylation of AKT1 68 0.58 35.61 2.8 5.00
97 INT139562 Transcription of IL18 10 0.68 6.14 2.73 5.00
98 INT77925 Negative_regulation of TEP1 21 0.53 15.23 2.62 5.00
99 INT90038 Negative_regulation of Ifnar2 4 0.35 1.69 2.58 5.00
100 INT306726 Localization of Il22 4 0.57 5.52 2.57 5.00
101 INT182312 Positive_regulation of Gene_expression of Birc5 26 0.69 25.3 2.32 5.00
102 INT250888 Negative_regulation of IL23A 4 0.30 6.13 2.15 5.00
103 INT101243 Regulation of STAT3 12 0.62 9.98 1.92 5.00
104 INT56925 Negative_regulation of TSC1 54 0.52 63.39 1.87 5.00
105 INT121784 Regulation of Gene_expression of Fas 7 0.38 5.68 1.86 5.00
106 INT208561 Gene_expression of Shh 51 0.78 9.57 1.77 5.00
107 INT113985 Positive_regulation of TP63 9 0.50 8.79 1.62 5.00
108 INT168681 Gene_expression of BMS1 5 0.37 2.7 1.62 5.00
109 INT193823 Positive_regulation of Gene_expression of TP63 7 0.18 7.74 1.57 5.00
110 INT110028 Transcription of Il12a 6 0.49 1.48 1.51 5.00
111 INT41719 Gene_expression of MTOR 27 0.77 19.43 1.44 5.00
112 INT285482 Negative_regulation of Il22 3 0.30 3.02 1.37 5.00
113 INT306739 Positive_regulation of Gene_expression of IL22 2 0.28 2.2 1.36 5.00
114 INT169907 Gene_expression of Rb1 25 0.60 21.95 1.32 5.00
115 INT139077 Negative_regulation of Ptch1 5 0.56 5.22 1.29 5.00
116 INT285470 Regulation of Il22 4 0.11 4.18 1.21 5.00
117 INT278117 Negative_regulation of TP63 5 0.32 3.38 1.13 5.00
118 INT135042 Gene_expression of Tg(MMTV-Notch4)3Rnc 9 0.15 5.17 1.13 5.00
119 INT237904 Negative_regulation of Localization of Hand1 5 0.24 3.52 1.09 5.00
120 INT306735 Positive_regulation of Positive_regulation of IL23A 4 0.26 3.25 1.04 5.00
121 INT155696 Gene_expression of PIK3CG 16 0.65 8.54 1.02 5.00
122 INT306723 Binding of Il22 3 0.11 2.44 0.97 5.00
123 INT182313 Regulation of Gene_expression of Birc5 18 0.60 15.34 0.96 5.00
124 INT167176 Regulation of Cdc2b 3 0.45 1.56 0.87 5.00
125 INT163758 Regulation of Stat1 17 0.54 5.23 0.87 5.00
126 INT256920 Binding of Irf3 2 0.36 1.38 0.84 5.00
127 INT114877 Gene_expression of Cdk4 12 0.69 5.98 0.79 5.00
128 INT44293 Regulation of TP63 6 0.24 2.88 0.76 5.00
129 INT142416 Binding of Ptch1 6 0.34 4.92 0.74 5.00
130 INT174553 Localization of Stat1 17 0.80 6.62 0.73 5.00
131 INT158303 Transcription of IL23A 2 0.52 0.81 0.72 5.00
132 INT306740 Localization of IL23A 3 0.58 2.66 0.69 5.00
133 INT153257 Regulation of Ptch1 6 0.36 5.92 0.67 5.00
134 INT306730 Regulation of Gene_expression of Il22 1 0.06 1.04 0.62 5.00
135 INT128498 Regulation of CCND1 17 0.39 12.51 0.58 5.00
136 INT306729 Negative_regulation of Ccl20 1 0.05 1.01 0.57 5.00
137 INT306725 Negative_regulation of Defb4 1 0.01 1.02 0.57 5.00
138 INT65919 Gene_expression of Ptch1 11 0.75 6.47 0.56 5.00
139 INT132781 Phosphorylation of PIK3CG 8 0.52 4.83 0.53 5.00
140 INT306741 Positive_regulation of Positive_regulation of TP63 2 0.05 1.16 0.49 5.00
141 INT61727 Gene_expression of B2 4 0.17 2.03 0.48 5.00
142 INT256628 Regulation of Nsdhl 2 0.11 4.12 0.43 5.00
143 INT299802 Negative_regulation of Transcription of IFNA1 2 0.09 0.54 0.41 5.00
144 INT196916 Negative_regulation of Rb1 13 0.42 14.29 0.4 5.00
145 INT262768 Negative_regulation of CD163L1 1 0.02 1.63 0.4 5.00
146 INT186272 Positive_regulation of Positive_regulation of Il12a 7 0.26 4.45 0.36 5.00
147 INT237161 Regulation of Ccnb1 5 0.17 2.71 0.32 5.00
148 INT306727 Positive_regulation of Positive_regulation of Il22 1 0.12 1.26 0.3 5.00
149 INT183055 Gene_expression of PTCH1 10 0.77 15.54 0.26 5.00
150 INT156207 Negative_regulation of Phosphorylation of MTOR 5 0.58 2.33 0.25 5.00
151 INT306742 Negative_regulation of Positive_regulation of IL23A 1 0.22 0.52 0.24 5.00
152 INT119080 Negative_regulation of PTK2 15 0.56 8.88 0.23 5.00
153 INT217832 Negative_regulation of Gene_expression of TSC1 5 0.04 5.45 0.21 5.00
154 INT156204 Phosphorylation of MTOR 15 0.82 3.99 0.21 5.00
155 INT170847 Gene_expression of Ccne2 6 0.58 2.98 0.21 5.00
156 INT232799 Regulation of Gene_expression of Shh 3 0.27 1.04 0.16 5.00
157 INT176246 Regulation of Cdk2 6 0.30 3.31 0.15 5.00
158 INT236916 Gene_expression of Ccnd2 5 0.46 2.48 0.14 5.00
159 INT172476 Transcription of NFE2L2 7 0.69 2.47 0.11 5.00
160 INT306736 Negative_regulation of Transcription of IL18 2 0.38 0.31 0.11 5.00
161 INT306724 Negative_regulation of Transcription of Il12a 1 0.18 0.3 0.1 5.00
162 INT256913 Gene_expression of Hr 6 0.46 35.3 0.1 5.00
163 INT306733 Negative_regulation of Transcription of IL23A 1 0.22 0.31 0.1 5.00
164 INT262775 Negative_regulation of Phosphorylation of PIK3CG 1 0.28 1.1 0.09 5.00
165 INT213515 Binding of Shh 8 0.37 1.92 0.08 5.00
166 INT262774 Negative_regulation of DLST 1 0.23 0.43 0.07 5.00
167 INT230866 Negative_regulation of Gene_expression of PIK3CG 2 0.28 1.37 0.07 5.00
168 INT205973 Binding of SHH 3 0.35 1.03 0.07 5.00
169 INT262778 Transcription of NFE2L3 1 0.02 1.24 0.06 5.00
170 INT256923 Regulation of Gene_expression of Casp8 2 0.11 2.31 0.04 5.00
171 INT179759 Gene_expression of IGKV2D-19 2 0.46 5.38 0.04 5.00
172 INT262776 Localization of SLAMF6 1 0.01 0.59 0.03 5.00
173 INT262767 Localization of MRGPRF 1 0.33 0.59 0.03 5.00
174 INT262779 Localization of PTK2 3 0.71 2.75 0 5.00
175 INT256907 Negative_regulation of Ifit2 1 0.26 1.71 0 5.00
176 INT262771 Negative_regulation of ZNF765 1 0.01 0.78 0 5.00
177 INT256914 Regulation of Oas2 1 0.22 0.92 0 5.00
178 INT256922 Regulation of Irgm1 1 0.03 0.91 0 5.00
179 INT256911 Gene_expression of Btn2a2 1 0.01 0.53 0 5.00
180 INT256625 Negative_regulation of Ptch2 1 0.42 1.27 0 5.00
181 INT256917 Localization of Ifnar2 1 0.60 0.99 0 5.00
182 INT256627 Regulation of Negative_regulation of Ptch2 1 0.32 1.33 0 5.00
183 INT256904 Negative_regulation of Ifi203 1 0.42 0.85 0 5.00
184 INT256935 Regulation of CCNT1 1 0.01 0.43 0 5.00
185 INT256925 Protein_catabolism of Ccnb1 1 0.24 0.74 0 5.00
186 INT256626 Regulation of Ptch2 1 0.28 1.11 0 5.00
187 INT256918 Negative_regulation of Irf1 1 0.24 1.71 0 5.00
188 INT256631 Positive_regulation of PTCH1 2 0.13 1.97 0 5.00
189 INT256919 Regulation of Mx1 1 0.21 0.92 0 5.00
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