D:Basal Cell Nevus Syndrome

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pChart

Disease Term
Synonyms Basal Cell Carcinoma Syndrome, Bcns, Carcinoma Syndrome Multiple Basal Cell Nevus Syndrome, FAMILIAL CUTANEOMANDIBULAR POLYONCOSIS, Fifth Phacomatosis, Gorlin Goltz Syndrome, GORLIN SYNDROME, Gorlin Syndrome 2, HEREDITARY CUTANEOMANDIBULAR POLYONCOSIS, JAW CYSTS BASAL CELL TUMORS SKELETAL ANOMALIES SYNDROME, Multiple Basal Cell
Documents 33
Hot Single Events 30
Hot Interactions 3

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Basal Cell Nevus Syndrome. They are ordered first by their relevance to Basal Cell Nevus Syndrome and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT256632 Binding of PTCH1 and Jkamp 1 0.00 2.32 0 100.00
2 INT345343 PTCH1 Regulation of Negative_regulation of SMO 1 0.09 2.3 0.13 97.36
3 INT260066 Binding of PHF2 and XPA 1 0.20 1.04 0 90.24
4 INT260067 Binding of PTCH1 and XPA 1 0.26 1.08 0 78.00
5 INT256629 Binding of Ptch1 and Shh 7 0.42 4.22 0.19 77.68
6 INT260070 Binding of PHF2 and SPTLC1 1 0.17 1.93 0.1 68.92
7 INT352525 SLC25A16 Negative_regulation of SMO 1 0.00 1.1 0 47.20
8 INT260072 Binding of BRCA2 and FANCC 1 0.37 0.63 0 26.56
9 INT260071 Binding of FANCC and XPA 1 0.24 0.76 0 23.44
10 INT355542 Binding of XRCC3 and BCC1 1 0.00 1.19 0.07 5.00
11 INT241588 Binding of FAS and Fas 1 0.05 2.34 0 5.00
12 INT260069 Binding of FANCC and PHF2 1 0.28 0.37 0 5.00
13 INT260074 Binding of BRCA2 and PTCH1 1 0.40 0.15 0 5.00
14 INT260073 Binding of FANCC and PTCH1 1 0.33 0.49 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Basal Cell Nevus Syndrome. They are ordered first by their pain relevance and then by number of times they were reported in Basal Cell Nevus Syndrome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT183055 Gene_expression of PTCH1 10 0.77 15.54 0.26 100.00
2 INT135299 Binding of PTCH1 10 0.48 12.16 0.84 100.00
3 INT256631 Positive_regulation of PTCH1 2 0.13 1.97 0 100.00
4 INT256628 Regulation of Nsdhl 2 0.11 4.12 0.43 99.84
5 INT139077 Negative_regulation of Ptch1 5 0.56 5.22 1.29 98.28
6 INT260086 Negative_regulation of MSRA 3 0.41 2.36 0.33 98.16
7 INT119063 Gene_expression of BRCA1 24 0.67 30.04 4.17 97.56
8 INT260083 Regulation of PTCH1 11 0.27 4.46 0.09 97.36
9 INT99176 Positive_regulation of Fap 4 0.13 7.5 0.22 96.86
10 INT216120 Negative_regulation of SMO 2 0.49 3.05 0.27 95.04
11 INT345344 Regulation of SMO 1 0.23 1.07 0.06 95.04
12 INT260080 Negative_regulation of Gene_expression of PTCH1 1 0.58 2.09 0 94.32
13 INT256626 Regulation of Ptch2 1 0.28 1.11 0 94.00
14 INT10797 Binding of CYP2D6 86 0.48 15.09 31.16 93.76
15 INT205968 Negative_regulation of PTCH1 2 0.58 2.35 0 90.40
16 INT260076 Binding of XPA 1 0.20 1.1 0 89.88
17 INT205973 Binding of SHH 3 0.35 1.03 0.07 87.84
18 INT213515 Binding of Shh 8 0.37 1.92 0.08 87.20
19 INT153257 Regulation of Ptch1 6 0.36 5.92 0.67 86.96
20 INT242822 Transcription of Fap 1 0.18 1.2 0 86.80
21 INT21737 Binding of MC1R 129 0.48 45.45 56.54 85.76
22 INT195206 Binding of BCC1 15 0.41 21.3 0.62 85.76
23 INT142416 Binding of Ptch1 6 0.34 4.92 0.74 85.12
24 INT49441 Negative_regulation of Cpox 494 0.59 303.22 177.46 83.76
25 INT940 Negative_regulation of Ptgs1 219 0.59 104.34 95.97 83.36
26 INT65919 Gene_expression of Ptch1 11 0.75 6.47 0.56 83.20
27 INT260075 Binding of PHF2 1 0.32 0.75 0 82.68
28 INT256627 Regulation of Negative_regulation of Ptch2 1 0.32 1.33 0 82.24
29 INT256625 Negative_regulation of Ptch2 1 0.42 1.27 0 82.24
30 INT56925 Negative_regulation of TSC1 54 0.52 63.39 1.87 81.20
31 INT158754 Gene_expression of XPA 3 0.57 4.24 0.2 78.72
32 INT260081 Negative_regulation of Transcription of PHF2 1 0.37 0.63 0 76.68
33 INT260085 Transcription of PHF2 1 0.60 1.36 0 76.36
34 INT68565 Gene_expression of Fap 14 0.57 24.39 1.14 66.04
35 INT232799 Regulation of Gene_expression of Shh 3 0.27 1.04 0.16 65.20
36 INT208561 Gene_expression of Shh 51 0.78 9.57 1.77 65.20
37 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 62.16
38 INT180265 Localization of BCC1 7 0.65 9.48 0.15 57.16
39 INT68094 Negative_regulation of SERPINB3 12 0.43 10.55 1.49 48.40
40 INT80339 Gene_expression of PHF2 3 0.73 2.3 0.26 45.68
41 INT238184 Gene_expression of FANCC 6 0.60 2.92 0.19 45.68
42 INT214981 Binding of FANCC 3 0.33 2.71 0.38 43.44
43 INT180264 Positive_regulation of BCC1 11 0.59 12.81 0.2 37.36
44 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 33.36
45 INT70614 Gene_expression of FAS 118 0.75 112.33 19.01 33.36
46 INT201239 Gene_expression of FOXM1 9 0.51 4.07 0.19 29.20
47 INT120247 Gene_expression of FOXE1 3 0.48 2.39 0.1 29.20
48 INT309533 Negative_regulation of BCC1 3 0.25 2.62 0.03 19.44
49 INT214984 Regulation of FANCC 2 0.40 3.19 0.23 16.08
50 INT260084 Negative_regulation of FANCC 1 0.39 0.44 0 16.08
51 INT284765 Gene_expression of BCC1 22 0.56 29.32 0.14 6.96
52 INT39153 Positive_regulation of PTGS2 182 0.70 96.16 60.6 5.56
53 INT55135 Positive_regulation of Gene_expression of PTGS2 137 0.70 80.32 38.46 5.56
54 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 5.24
55 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 5.00
56 INT117220 Positive_regulation of TLR4 64 0.69 53.61 17.33 5.00
57 INT77620 Gene_expression of Fas 146 0.78 72.4 16.61 5.00
58 INT88014 Positive_regulation of Gene_expression of Fas 29 0.50 14.84 7.47 5.00
59 INT97797 Localization of TLR4 18 0.77 13.78 6 5.00
60 INT80033 Binding of FAS 37 0.48 41.19 5.67 5.00
61 INT87022 Gene_expression of Apc 68 0.67 46.98 5.22 5.00
62 INT113517 Binding of Fas 16 0.37 15.86 4.62 5.00
63 INT188406 Binding of Fasl 19 0.44 24.67 3.17 5.00
64 INT244704 Gene_expression of ARG1 65 0.75 37.74 1.9 5.00
65 INT90926 Positive_regulation of GLI2 12 0.45 4.99 1.74 5.00
66 INT220177 Binding of Apc 21 0.37 15.34 1.37 5.00
67 INT152951 Negative_regulation of LEF1 5 0.41 3.22 1.31 5.00
68 INT110434 Positive_regulation of Gene_expression of Apc 20 0.50 11.37 1.3 5.00
69 INT68564 Binding of Fap 6 0.32 6.75 0.65 5.00
70 INT236786 Positive_regulation of Localization of TLR4 2 0.45 1.89 0.57 5.00
71 INT214985 Localization of FANCC 6 0.55 1.43 0.43 5.00
72 INT225667 Transcription of Apc 3 0.52 3.73 0.32 5.00
73 INT260079 Transcription of FANCC 2 0.62 1.55 0.26 5.00
74 INT19359 Binding of BRCA2 5 0.47 2.63 0.19 5.00
75 INT242819 Negative_regulation of Gene_expression of Apc 4 0.37 5.6 0.1 5.00
76 INT140494 Negative_regulation of Fap 3 0.37 2.3 0.08 5.00
77 INT183070 Transcription of PTCH1 2 0.68 0.95 0.04 5.00
78 INT242821 Negative_regulation of Localization of Fap 1 0.11 1.91 0 5.00
79 INT260088 Negative_regulation of Transcription of PTCH1 1 0.43 0.4 0 5.00
80 INT345345 Gene_expression of MMS 1 0.17 1.36 0 5.00
81 INT260090 Regulation of XPA 1 0.17 0.96 0 5.00
82 INT260087 Regulation of Regulation of PHF2 1 0.23 0.19 0 5.00
83 INT242820 Localization of Fap 1 0.20 1.9 0 5.00
84 INT260089 Localization of PTCH1 1 0.70 0.37 0 5.00
85 INT352526 Protein_catabolism of BCC1 1 0.51 0.65 0 5.00
86 INT260077 Transcription of XPA 1 0.43 0.33 0 5.00
87 INT260078 Regulation of PHF2 1 0.23 1.65 0 5.00
88 INT242823 Binding of CTNND2 1 0.36 6 0 5.00
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