D:Benign Monoclonal Gammopathies

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Disease Term
Synonyms Benign Monoclonal Gammapathies, BENIGN MONOCLONAL GAMMAPATHY, BENIGN MONOCLONAL GAMMOPATHY, Gammapathies Benign Monoclonal, Gammapathy Benign Monoclonal, Gammopathies Benign Monoclonal, Gammopathy Benign Monoclonal, Monoclonal Gammapathies Benign, Monoclonal Gammapathy Benign, Monoclonal Gammopathy Benign
Documents 8
Hot Single Events 15
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Benign Monoclonal Gammopathies. They are ordered first by their relevance to Benign Monoclonal Gammopathies and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT49283 Binding of IGLL1 and IFNK 1 0.02 0.9 0.1 99.76
2 INT219154 Binding of HMGB1 and TLR4 2 0.17 4.45 0.93 82.16
3 INT219150 Binding of CXCL11 and CXCR7 1 0.09 1.77 0.09 68.88
4 INT219151 IL18 Positive_regulation of CASP1 1 0.01 1.05 0.3 5.00
5 INT219156 NLRP3 Positive_regulation of IL1B 1 0.01 1.03 0.27 5.00
6 INT219194 Nlrp3 Positive_regulation of IL1B 1 0.04 1.03 0.26 5.00
7 INT219193 Nlrp3 Positive_regulation of Positive_regulation of NLRP3 1 0.24 1.03 0.26 5.00
8 INT219153 IL6 Positive_regulation of IL23A 1 0.02 0.45 0.21 5.00
9 INT171127 Binding of CD28 and IFN1@ 1 0.39 0.36 0.19 5.00
10 INT219157 Binding of KLRB1 and CLEC2D 1 0.02 0.41 0.12 5.00
11 INT219152 NLRP3 Positive_regulation of Positive_regulation of CASP1 1 0.02 0.83 0.1 5.00
12 INT219155 Binding of HLA-G and LILRB2 1 0.15 0.23 0.1 5.00
13 INT332588 Binding of RAPH1 and MND1 1 0.01 3.88 0.07 5.00
14 INT219149 FBXO8 Positive_regulation of Localization of IL10 1 0.01 0.14 0.05 5.00
15 INT219195 Binding of PDC and fc 1 0.01 0.24 0.04 5.00
16 INT332587 MND1 Positive_regulation of Binding of RAPH1 and MND1 1 0.00 2.21 0.03 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Benign Monoclonal Gammopathies. They are ordered first by their pain relevance and then by number of times they were reported in Benign Monoclonal Gammopathies. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT332592 Binding of MND1 1 0.08 9.21 0.16 99.80
2 INT49286 Binding of IFNK 2 0.25 2.48 0.34 99.76
3 INT167056 Gene_expression of CALR 29 0.75 20.05 1.25 90.32
4 INT162801 Localization of CALR 7 0.73 8.69 0.6 90.32
5 INT184269 Gene_expression of HMGB1 51 0.77 42.96 4.55 88.96
6 INT56149 Localization of CD8A 56 0.74 30.41 5.75 87.40
7 INT171133 Localization of CD28 8 0.71 3.42 1.48 87.24
8 INT184288 Localization of HMGB1 20 0.61 14.5 3.84 87.00
9 INT116902 Positive_regulation of CD28 17 0.47 13.56 4.27 86.00
10 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44 85.52
11 INT53590 Gene_expression of PRF1 33 0.58 23.46 10.02 85.04
12 INT90584 Gene_expression of GZMB 15 0.14 13.81 1.86 85.04
13 INT49285 Regulation of IFNK 1 0.18 0.81 0.06 83.32
14 INT49284 Regulation of MYOM2 2 0.08 3.27 0.13 82.92
15 INT160799 Regulation of IGFALS 11 0.29 9.09 0.7 81.44
16 INT171134 Gene_expression of CD28 67 0.65 32.55 13.61 76.72
17 INT19856 Gene_expression of CD8A 240 0.75 147.86 26.39 76.24
18 INT117223 Gene_expression of TLR4 348 0.78 206.18 54.42 75.80
19 INT143158 Negative_regulation of Gene_expression of TLR4 31 0.56 20.62 5.69 75.80
20 INT34729 Positive_regulation of IFN1@ 233 0.67 128.04 30.38 75.12
21 INT184272 Binding of HMGB1 14 0.37 8.78 2.49 73.24
22 INT100692 Phosphorylation of STAT6 5 0.78 3.42 1.7 53.36
23 INT105569 Binding of IGFALS 13 0.25 17.31 1.36 52.16
24 INT132822 Localization of IL13 26 0.67 22.85 6.66 47.12
25 INT240280 Gene_expression of IGFALS 14 0.42 20.38 0.95 36.48
26 INT74423 Localization of IL10 91 0.80 61.6 22.95 35.04
27 INT148207 Gene_expression of CTLA4 53 0.77 29.13 12.07 33.60
28 INT169015 Gene_expression of FOXP3 50 0.60 33.18 8.4 33.60
29 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 20.16
30 INT6512 Gene_expression of PTH 103 0.77 76.29 6.33 18.00
31 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 13.28
32 INT240281 Positive_regulation of IGFALS 11 0.31 10.44 0.56 12.64
33 INT240278 Localization of IGFALS 11 0.53 9.44 0.29 10.64
34 INT332589 Localization of MND1 1 0.12 2.01 0 10.64
35 INT198568 Regulation of DCPS 17 0.34 16.26 1.86 6.40
36 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
37 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
38 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
39 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
40 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 5.00
41 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 5.00
42 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 5.00
43 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 5.00
44 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 5.00
45 INT73502 Positive_regulation of IL10 154 0.69 124.87 43.5 5.00
46 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 5.00
47 INT55583 Localization of IFNA1 135 0.78 85.07 24.13 5.00
48 INT8775 Binding of IGHE 167 0.48 102.61 23.54 5.00
49 INT19330 Binding of HLA-A 99 0.48 76.26 22.85 5.00
50 INT14700 Regulation of IFNA1 111 0.45 66.16 21.52 5.00
51 INT14701 Negative_regulation of IFNA1 118 0.54 84.19 20.08 5.00
52 INT18010 Positive_regulation of CD40LG 122 0.70 100.8 18.46 5.00
53 INT182217 Gene_expression of CCR9 8 0.75 44.81 18.15 5.00
54 INT70145 Gene_expression of Trav6-3 136 0.76 69.6 18.05 5.00
55 INT116978 Gene_expression of CCR6 53 0.78 56 17.73 5.00
56 INT2216 Gene_expression of SELL 92 0.77 59.29 17.71 5.00
57 INT45142 Gene_expression of DCPS 109 0.56 84.71 16.87 5.00
58 INT10709 Negative_regulation of CD4 106 0.59 95.6 14.89 5.00
59 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83 5.00
60 INT36287 Binding of CD4 96 0.47 58.93 11.88 5.00
61 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 5.00
62 INT24816 Binding of CD40LG 68 0.47 45.48 11.56 5.00
63 INT16449 Binding of IGHG3 67 0.48 39.55 10.59 5.00
64 INT94454 Gene_expression of CD68 73 0.72 63.94 10.43 5.00
65 INT159631 Positive_regulation of DCPS 60 0.27 43.23 10.3 5.00
66 INT10019 Binding of CD8A 57 0.36 31.49 10.08 5.00
67 INT73504 Binding of CD28 35 0.45 15.99 10.04 5.00
68 INT73497 Regulation of IL10 33 0.45 22.6 9.19 5.00
69 INT1118 Gene_expression of C6orf25 73 0.77 47.24 9.1 5.00
70 INT2280 Negative_regulation of TNFAIP1 70 0.43 69.43 8.36 5.00
71 INT17049 Localization of CD4 57 0.75 35.33 6.89 5.00
72 INT159632 Localization of DCPS 24 0.21 18.24 6.8 5.00
73 INT23174 Gene_expression of NLRP3 51 0.72 35.49 6.47 5.00
74 INT81049 Positive_regulation of CASP1 44 0.67 19.97 5.69 5.00
75 INT171562 Regulation of IL4 19 0.36 12.12 5.33 5.00
76 INT45753 Localization of CD40LG 45 0.79 32.31 5.28 5.00
77 INT130290 Positive_regulation of Localization of IL10 16 0.47 9.38 4.75 5.00
78 INT36221 Positive_regulation of Nlrp3 25 0.68 19.7 4.5 5.00
79 INT99020 Gene_expression of Nlrp3 23 0.75 18.86 4.4 5.00
80 INT5148 Regulation of CD40LG 25 0.44 21.58 4.05 5.00
81 INT204529 Positive_regulation of TLR9 18 0.62 15.62 3.99 5.00
82 INT173519 Positive_regulation of Localization of IFNA1 27 0.49 24.48 3.9 5.00
83 INT35175 Localization of IL18 18 0.80 12.96 3.83 5.00
84 INT143494 Binding of DCPS 24 0.29 24.41 3.67 5.00
85 INT15982 Positive_regulation of NLRP3 25 0.65 23.19 3.57 5.00
86 INT85130 Regulation of IL5 14 0.27 8.37 3.55 5.00
87 INT73500 Regulation of IL13 12 0.36 10.37 3.53 5.00
88 INT182233 Gene_expression of CCR4 14 0.43 6.55 3.31 5.00
89 INT52021 Regulation of IGHG3 34 0.39 22.43 3.3 5.00
90 INT43907 Binding of CD79A 28 0.48 28.11 3.04 5.00
91 INT156148 Gene_expression of CTGF 16 0.78 9.98 2.87 5.00
92 INT57957 Localization of TXNRD1 14 0.64 4.01 2.7 5.00
93 INT203048 Gene_expression of PDCD1 13 0.78 8.5 2.62 5.00
94 INT65472 Binding of HLA-G 9 0.36 6.06 2.6 5.00
95 INT219180 Gene_expression of TLR7 13 0.68 9.51 2.21 5.00
96 INT182230 Binding of CCR9 3 0.36 4.32 2.19 5.00
97 INT39453 Negative_regulation of TCN2 12 0.59 3.98 2.13 5.00
98 INT156720 Localization of CD1D 7 0.68 1.1 2.09 5.00
99 INT15580 Gene_expression of TCN2 16 0.44 7.59 1.97 5.00
100 INT18007 Positive_regulation of C6orf25 23 0.66 14.98 1.95 5.00
101 INT219191 Localization of IL22 5 0.31 3.6 1.88 5.00
102 INT3911 Gene_expression of TNFAIP1 29 0.65 21.68 1.85 5.00
103 INT126759 Negative_regulation of Nlrp3 5 0.41 2.95 1.58 5.00
104 INT23171 Negative_regulation of NLRP3 7 0.37 4.15 1.53 5.00
105 INT219183 Localization of IL26 3 0.39 3.61 1.49 5.00
106 INT116900 Positive_regulation of PRF1 5 0.49 4 1.39 5.00
107 INT128769 Negative_regulation of Localization of IFNA1 8 0.24 6.85 1.35 5.00
108 INT219159 Positive_regulation of TLR7 8 0.55 2.37 1.32 5.00
109 INT126907 Positive_regulation of Gene_expression of CD68 8 0.42 10.94 1.23 5.00
110 INT87988 Gene_expression of ASAH1 9 0.77 9.75 1.18 5.00
111 INT219168 Positive_regulation of Localization of HMGB1 5 0.36 4 1.16 5.00
112 INT191527 Positive_regulation of Gene_expression of NLRP3 6 0.50 8.65 1.15 5.00
113 INT187161 Binding of SLEB1 9 0.05 11.8 1.09 5.00
114 INT147336 Gene_expression of HLA-G 12 0.75 7.27 1.08 5.00
115 INT56151 Positive_regulation of Positive_regulation of CD8A 11 0.34 9.74 0.94 5.00
116 INT219135 Positive_regulation of Gene_expression of Nlrp3 4 0.49 3.52 0.93 5.00
117 INT70027 Positive_regulation of Gene_expression of C6orf25 10 0.62 7.21 0.83 5.00
118 INT219184 Localization of IL17F 2 0.05 1.62 0.78 5.00
119 INT116981 Localization of CCL20 3 0.80 3.49 0.74 5.00
120 INT186798 Regulation of TLR3 5 0.42 3.13 0.69 5.00
121 INT230410 Negative_regulation of Gene_expression of TNFAIP1 3 0.16 3.67 0.63 5.00
122 INT15981 Positive_regulation of Positive_regulation of NLRP3 2 0.44 1.02 0.62 5.00
123 INT219136 Positive_regulation of Positive_regulation of Nlrp3 3 0.49 2.61 0.58 5.00
124 INT219165 Localization of TSLP 1 0.21 1.11 0.52 5.00
125 INT73731 Binding of RAPH1 9 0.33 14.58 0.5 5.00
126 INT171132 Binding of HLA-F 1 0.05 0.6 0.5 5.00
127 INT219172 Localization of IL25 1 0.12 0.99 0.49 5.00
128 INT219178 Negative_regulation of Localization of HMGB1 1 0.22 1.26 0.45 5.00
129 INT264689 Negative_regulation of IGFALS 10 0.33 12.58 0.45 5.00
130 INT266786 Binding of ASAH1 2 0.11 3.87 0.44 5.00
131 INT219170 Gene_expression of IL25 1 0.11 0.76 0.44 5.00
132 INT80754 Localization of PRF1 6 0.78 2.78 0.42 5.00
133 INT219171 Negative_regulation of Positive_regulation of TLR9 1 0.18 1.3 0.39 5.00
134 INT219182 Negative_regulation of Positive_regulation of TLR7 1 0.24 1.3 0.39 5.00
135 INT219187 Negative_regulation of Binding of CCR9 1 0.16 1.37 0.38 5.00
136 INT219181 Negative_regulation of ITGA1 1 0.05 1.34 0.32 5.00
137 INT219134 Negative_regulation of Positive_regulation of Nlrp3 2 0.41 1.42 0.3 5.00
138 INT219162 Localization of CTGF 1 0.50 2.62 0.29 5.00
139 INT109451 Binding of PRF1 2 0.35 2.25 0.27 5.00
140 INT171130 Protein_catabolism of CD8A 1 0.83 0.47 0.27 5.00
141 INT171131 Protein_catabolism of CD28 1 0.73 0.47 0.27 5.00
142 INT219173 Negative_regulation of Gene_expression of NLRP3 1 0.19 1.02 0.26 5.00
143 INT219174 Negative_regulation of Positive_regulation of NLRP3 1 0.19 1.02 0.26 5.00
144 INT219133 Negative_regulation of Gene_expression of Nlrp3 1 0.41 1.02 0.26 5.00
145 INT219175 Localization of TLR7 2 0.49 1.32 0.25 5.00
146 INT36479 Binding of NR0B2 2 0.36 3.5 0.21 5.00
147 INT219161 Localization of CXCL9 2 0.44 0.61 0.2 5.00
148 INT219192 Positive_regulation of Regulation of CD40LG 2 0.43 2.9 0.17 5.00
149 INT229301 Gene_expression of NR0B2 3 0.18 3.49 0.16 5.00
150 INT219160 Positive_regulation of CTGF 2 0.29 2.95 0.15 5.00
151 INT219176 Gene_expression of CLEC2D 2 0.23 0.62 0.13 5.00
152 INT219189 Positive_regulation of Regulation of IFNA1 2 0.10 0.53 0.13 5.00
153 INT219179 Positive_regulation of Regulation of IL10 1 0.08 0.45 0.13 5.00
154 INT219164 Regulation of Positive_regulation of CD40LG 1 0.04 1.51 0.13 5.00
155 INT175556 Regulation of Positive_regulation of PTH 3 0.39 2.34 0.12 5.00
156 INT155154 Binding of CD1D 2 0.36 1.7 0.12 5.00
157 INT219163 Gene_expression of LILRB2 1 0.23 0.23 0.1 5.00
158 INT219190 Binding of LILRB2 1 0.14 0.23 0.1 5.00
159 INT219167 Gene_expression of TNFSF4 1 0.23 1.35 0.08 5.00
160 INT283245 Gene_expression of MND1 2 0.11 1.94 0.07 5.00
161 INT332590 Negative_regulation of Gene_expression of TCN2 1 0.05 1.2 0.06 5.00
162 INT219166 Positive_regulation of Gene_expression of RAG2 1 0.23 1.17 0.05 5.00
163 INT219188 Gene_expression of RAG2 1 0.30 1.17 0.05 5.00
164 INT219185 Localization of KHSRPP1 1 0.01 0.13 0.05 5.00
165 INT219169 Positive_regulation of Localization of CD1D 1 0.22 0.65 0.03 5.00
166 INT219186 Negative_regulation of KLF1 1 0.01 0.31 0 5.00
167 INT332591 Positive_regulation of MND1 1 0.11 1.56 0 5.00
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