D:Bone Cancer

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Disease Term
Synonyms Bone Cancers, BONE CARCINOMA, BONE CARCINOMAS, BONE DISEASE, Bone Diseases, Bone Disorder, Bone Disorders, BONE DYSFUNCTIONS, Bone Dysplasia, Bone Dysplasias, BONE HYPERPLASIA
Documents 1986
Hot Single Events 200
Hot Interactions 45

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Bone Cancer. They are ordered first by their relevance to Bone Cancer and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT351364 LPA Positive_regulation of Trpv1 1 0.02 1.15 0.78 100.00
2 INT254434 Binding of Lrp5 and Best1 3 0.29 2.53 0 100.00
3 INT186672 IL8 Positive_regulation of Transcription of PTH 1 0.01 1.83 0.85 99.76
4 INT186673 IL8 Positive_regulation of Positive_regulation of PTH 1 0.01 0.92 0.42 99.76
5 INT89475 TGFB1 Positive_regulation of Gene_expression of PTHLH 3 0.61 3.64 0.21 98.44
6 INT351366 LPA Positive_regulation of Rab38 1 0.00 0.95 1.53 98.28
7 INT208152 Binding of CDK4 and MDM2 1 0.01 1.11 0 98.28
8 INT351374 Mir470 Negative_regulation of Ntrk3 1 0.00 1.55 0.7 98.18
9 INT351375 Mir470 Negative_regulation of Ntrk2 1 0.01 1.54 0.7 98.18
10 INT351376 Mir470 Negative_regulation of Ntrk1 1 0.01 1.54 0.7 98.18
11 INT225263 S100a7a Regulation of Phosphorylation of Egf 1 0.04 0.84 0 98.04
12 INT351352 Binding of Trpv1 and Lpar1 1 0.21 5.86 4.62 97.08
13 INT295005 Binding of TNFRSF11A and Tnfsf11 3 0.20 2.02 0.09 95.88
14 INT295006 Binding of TNFRSF11A and Tnfrsf11b 2 0.10 1.6 0.04 95.88
15 INT295003 Binding of Tnfrsf11b and Tnfsf11 3 0.22 1.85 0.08 95.68
16 INT307100 Trpv1 Regulation of Binding of Trpa1 1 0.31 1.81 0.97 94.80
17 INT307103 Trpa1 Regulation of Binding of Trpv1 1 0.31 1.81 0.97 94.80
18 INT93293 Ngf Regulation of Trpv1 2 0.28 0.71 1.9 92.88
19 INT262572 Ngf Positive_regulation of Mapk1 2 0.04 0.52 0.81 92.88
20 INT262564 Ngf Positive_regulation of Pik3r1 1 0.08 0.36 0.8 92.88
21 INT262579 Ngf Positive_regulation of Prkca 1 0.07 0.36 0.8 92.88
22 INT262580 Ngf Positive_regulation of Hspg2 1 0.03 0.35 0.72 92.88
23 INT77646 Binding of Ngf and Ntrk1 23 0.40 7.85 9.26 91.68
24 INT205611 Gm6668 Negative_regulation of Fgfr1 1 0.01 1.59 0 90.80
25 INT205612 Gm6668 Negative_regulation of Pdgfrb 1 0.00 1.57 0 90.00
26 INT314369 Tnfsf11 Negative_regulation of Gene_expression of Tnfrsf11b 1 0.08 2.2 0.05 89.68
27 INT123462 Binding of TNF and Tnfrsf11b 3 0.21 3.52 0.24 89.48
28 INT123461 Binding of TNFSF10 and Tnfrsf11b 1 0.00 1.34 0.08 89.48
29 INT205614 Gm6668 Negative_regulation of Kdr 1 0.01 1.5 0 89.12
30 INT351367 LPA Regulation of Trpv1 1 0.01 0.83 0.69 88.48
31 INT205613 Gm6668 Negative_regulation of Akt1 1 0.00 0.94 0 88.32
32 INT140659 Phax Positive_regulation of Trpv1 3 0.49 0.68 2.18 87.60
33 INT343546 Negative_regulation of ROCK1 Negative_regulation of Gene_expression of PTHLH 1 0.16 3.28 0.03 86.64
34 INT352547 Binding of CFTR and DMD 1 0.01 1.42 0.35 85.04
35 INT314370 Adipoq Positive_regulation of Tnfrsf11a 1 0.04 1.26 0.03 83.76
36 INT88279 Ngf Positive_regulation of Ntrk1 5 0.76 3.06 5.23 83.68
37 INT351379 Ngf Positive_regulation of Binding of Ngf and Ntrk1 1 0.38 0.63 1.21 83.68
38 INT314374 Binding of Ptprc and Thy1 1 0.04 0.85 0 83.52
39 INT314371 Binding of Cd34 and Thy1 1 0.08 0.9 0 83.52
40 INT314373 Binding of Cd34 and Eng 1 0.08 0.9 0 83.16
41 INT314372 Binding of Eng and Ptprc 1 0.04 0.84 0 83.16
42 INT145775 Ngf Positive_regulation of Trpv1 11 0.72 7.71 11.25 83.12
43 INT342385 Positive_regulation of Binding of Lrp5 and Vdr 1 0.53 0.98 0 81.60
44 INT245110 Binding of MMP9 and Mmp9 1 0.08 1.53 0 81.32
45 INT351365 LPA Positive_regulation of Localization of Il6 1 0.00 1.79 0.54 80.12
46 INT121226 Ngf Regulation of Gene_expression of Trpv1 2 0.62 0.7 1.44 79.20
47 INT342381 Binding of Lrp5 and Vdr 1 0.55 0.97 0 78.88
48 INT289793 Binding of Comp and Ecm1 1 0.05 2.5 0.12 78.40
49 INT289790 Binding of Col7a1 and Comp 1 0.14 1.2 0.12 78.40
50 INT289794 Binding of Comp and Fn1 1 0.07 2.59 0.12 78.40
51 INT351349 Prkcg Positive_regulation of Binding of Lpar1 1 0.15 2 2.82 76.16
52 INT106676 Binding of Trpv1 and Phax 18 0.34 4.19 12.36 76.16
53 INT301289 Positive_regulation of Clec5a Positive_regulation of Gene_expression of Atp6v0d2 1 0.02 1.01 0.28 76.00
54 INT321891 Dkk1 Negative_regulation of Wnt2 1 0.12 0.94 0.05 75.24
55 INT351351 Prkcg Regulation of Lpar1 1 0.12 0.58 0.72 75.20
56 INT352269 Binding of Jund and Adora1 1 0.15 1.2 1.25 75.20
57 INT351350 Prkaca Regulation of Lpar1 1 0.04 0.58 0.72 74.88
58 INT335888 Lrp5 Negative_regulation of Gene_expression of Tph1 1 0.22 0.15 0.21 73.56
59 INT182644 Binding of CXCR4 and Cxcr4 1 0.10 0.66 0.09 73.12
60 INT154989 Phax Positive_regulation of Positive_regulation of Ephb1 1 0.22 0.92 0.69 71.80
61 INT321890 Slc3a2 Regulation of Dkk1 1 0.01 0.93 0.04 70.96
62 INT128221 Binding of IL6ST and Il6 2 0.00 0.73 0.17 69.76
63 INT209881 Binding of TNFRSF11B and TNFSF11 8 0.36 8.92 0.86 68.48
64 INT182636 Binding of TNFSF11 and TNFRSF11A 16 0.29 17.5 0.84 65.68
65 INT192275 Binding of BRD4 and C15orf55 1 0.27 0.61 0.04 65.08
66 INT182635 Binding of CCR5 and CCL5 2 0.09 4.19 3 65.04
67 INT182634 Binding of CCR5 and MIP 2 0.39 1.29 0.2 65.04
68 INT225262 Egf Regulation of Gene_expression of S100a7a 1 0.04 3.31 0.06 63.88
69 INT145661 Ptger2 Positive_regulation of Gene_expression of VEGFA 4 0.27 2.73 0.6 63.84
70 INT225258 Egf Positive_regulation of Gene_expression of S100a7a 1 0.07 1.7 0 60.48
71 INT203638 Binding of MR1 and GOPC 1 0.04 1.43 0.05 58.60
72 INT351373 Ngf Positive_regulation of Gene_expression of Ntrk1 1 0.35 0.41 1.18 57.80
73 INT351378 Gene_expression of Ngf Positive_regulation of Ntrk1 1 0.35 0.41 1.18 57.80
74 INT351377 Gene_expression of Ngf Positive_regulation of Gene_expression of Ntrk1 1 0.35 0.41 1.18 57.80
75 INT75355 Negative_regulation of GCG Regulation of Gh 1 0.01 1.26 0.18 57.12
76 INT75356 GCG Regulation of Gh 1 0.01 1.25 0.18 57.12
77 INT278242 MSC Regulation of Gene_expression of Cd36 1 0.08 1.17 0 55.08
78 INT343548 GLI2 Positive_regulation of Gene_expression of PTHLH 1 0.28 0.94 0 54.20
79 INT343549 GLI2 Positive_regulation of GYPA 1 0.05 0.95 0 54.20
80 INT343541 PTHLH Positive_regulation of GYPA 1 0.03 0.95 0 53.84
81 INT341666 ALPI Positive_regulation of ENPEP 1 0.01 1.05 0 53.24
82 INT289789 Comp Positive_regulation of Gene_expression of Rer1 1 0.55 0.8 0.03 52.68
83 INT245111 MMP9 Positive_regulation of Localization of Gtf3a 1 0.00 0.99 0 50.88
84 INT351380 Ngf Regulation of TPM1 1 0.44 2.17 2.11 50.00
85 INT341294 DRG1 Positive_regulation of Atf3 1 0.01 0 0.1 50.00
86 INT189992 Binding of Ptger2 and Pawr 1 0.00 2.89 0 50.00
87 INT189993 Binding of Bcl2 and Ptger2 1 0.00 1.43 0 50.00
88 INT312289 Binding of Col9a1 and Comp 1 0.09 1.38 0 48.08
89 INT312291 Binding of Comp and Matn3 1 0.06 1.37 0 48.08
90 INT239080 Binding of PPY and KAT2B 1 0.02 2.38 0 42.40
91 INT128214 Binding of Il6 and Stap1 1 0.00 0 0.04 41.36
92 INT174104 Binding of HSPG2 and Ache 1 0.16 0.98 0.09 38.12
93 INT269759 PTH Positive_regulation of DMD 2 0.06 0.37 0.03 37.48
94 INT344383 Olfr360 Regulation of Gene_expression of Efnb1 1 0.01 1.27 0.74 30.48
95 INT185733 Hpse Positive_regulation of Gene_expression of Tnfrsf11b 1 0.20 0.24 0 29.96
96 INT225260 S100a7a Positive_regulation of Phosphorylation of Egfr 1 0.07 0.18 0 29.48
97 INT278229 MSC Positive_regulation of Gene_expression of ALB 1 0.06 0.3 0 26.80
98 INT289795 Binding of COMP and Comp 1 0.02 0.99 0 20.20
99 INT140660 Phax Negative_regulation of Trpv1 2 0.08 0.58 0.84 18.96
100 INT298006 CHDM Positive_regulation of Gene_expression of PDGFRB 1 0.16 1.08 0.07 17.96
101 INT301292 Negative_regulation of Clec5a Negative_regulation of TNF 1 0.05 1.04 0.27 17.36
102 INT252895 PTTG1 Regulation of Gene_expression of VEGFA 1 0.03 0.15 0 16.00
103 INT209409 Binding of CALM1 and NHS 2 0.27 0.58 1.32 9.52
104 INT335882 Dkk1 Negative_regulation of Wnt2 1 0.02 0.15 0 8.96
105 INT182194 Binding of IL8 and CXCR2 10 0.56 7.14 4.16 5.00
106 INT208572 Binding of IL8 and CXCR1 6 0.33 5.2 3.08 5.00
107 INT344386 Efnb1 Positive_regulation of Phosphorylation of Ephb2 1 0.15 2.85 2.13 5.00
108 INT262558 Phax Positive_regulation of Trpv1 1 0.01 1.26 1.92 5.00
109 INT262568 Prkaca Regulation of Trpv1 2 0.10 0.65 1.38 5.00
110 INT121096 Binding of Calca and Trpv1 3 0.37 1.23 1.29 5.00
111 INT242623 Binding of Ntf3 and Ntrk3 5 0.22 1.31 1.29 5.00
112 INT310066 Negative_regulation of Pain1 Positive_regulation of Faah 1 0.03 1.32 1.23 5.00
113 INT310069 Negative_regulation of Pain1 Positive_regulation of Mgll 1 0.02 1.32 1.23 5.00
114 INT310068 Pain1 Positive_regulation of Faah 1 0.03 1.3 1.22 5.00
115 INT310067 Pain1 Positive_regulation of Mgll 1 0.02 1.29 1.21 5.00
116 INT230019 Binding of HLA-B and ERAL1 1 0.00 2.23 1.1 5.00
117 INT344389 Ephb2 Positive_regulation of Phosphorylation of Grin2b 1 0.16 1.46 0.98 5.00
118 INT344381 Olfr360 Negative_regulation of Gene_expression of Grin2b 1 0.01 1.17 0.93 5.00
119 INT344390 Olfr360 Negative_regulation of Phosphorylation of Grin2b 1 0.01 1.17 0.93 5.00
120 INT344388 Efnb1 Positive_regulation of Phosphorylation of Grin2b 1 0.40 1.45 0.92 5.00
121 INT281651 Phax Positive_regulation of Gene_expression of Trpv1 1 0.09 0.89 0.79 5.00
122 INT245564 Runx3 Negative_regulation of Ntrk2 3 0.61 1.61 0.79 5.00
123 INT262582 F2rl1 Regulation of Positive_regulation of Prkca 1 0.03 0.58 0.78 5.00
124 INT262562 F2rl1 Regulation of Trpv1 1 0.12 0.58 0.77 5.00
125 INT207391 Il17a Positive_regulation of Gene_expression of Tnfsf11 2 0.05 1.19 0.77 5.00
126 INT262563 Negative_regulation of Pax3 Regulation of Calca 1 0.01 0.75 0.76 5.00
127 INT262569 Pax3 Regulation of Calca 1 0.00 0.75 0.76 5.00
128 INT262577 Localization of Ngf Positive_regulation of Positive_regulation of Mapk14 1 0.05 0.92 0.75 5.00
129 INT262578 Prkaca Positive_regulation of Localization of Calca 1 0.03 0.71 0.75 5.00
130 INT262573 Par2 Regulation of Positive_regulation of Prkca 1 0.05 0.57 0.72 5.00
131 INT262581 Prkca Positive_regulation of Phosphorylation of Trpv1 1 0.13 0.28 0.71 5.00
132 INT186674 Binding of BGLAP and CYP27A1 1 0.01 1.91 0.71 5.00
133 INT262574 Gnaq Positive_regulation of Prkca 1 0.00 0.57 0.71 5.00
134 INT262566 Par2 Regulation of Trpv1 1 0.20 0.57 0.71 5.00
135 INT262571 Phosphorylation of Trpv1 Positive_regulation of Localization of Calca 1 0.17 0.71 0.7 5.00
136 INT262570 Binding of Pax3 and Trpv1 1 0.02 1.05 0.67 5.00
137 INT262576 Binding of Calca and Trpv1 1 0.13 1.05 0.66 5.00
138 INT344387 Efnb2 Positive_regulation of Phosphorylation of Tyr 1 0.01 1.05 0.66 5.00
139 INT259088 Trpv1 Positive_regulation of Calca 1 0.32 1.02 0.65 5.00
140 INT281650 Trpv1 Positive_regulation of Localization of Calca 1 0.12 0.71 0.61 5.00
141 INT252869 Binding of Trpv1 and Phax 2 0.01 0.18 0.6 5.00
142 INT281648 Negative_regulation of Binding of Trpv1 and Fig4 1 0.14 0.69 0.55 5.00
143 INT352270 Tnf Positive_regulation of GZMA 1 0.13 2.43 0.55 5.00
144 INT190702 CD40 Positive_regulation of Gene_expression of F3 1 0.00 1.4 0.55 5.00
145 INT281647 Binding of Trpv1 and Fig4 1 0.12 0.68 0.55 5.00
146 INT254279 Il13 Positive_regulation of Gene_expression of Tnfsf11 1 0.05 0.79 0.54 5.00
147 INT254280 Il4 Positive_regulation of Gene_expression of Tnfsf11 1 0.05 0.79 0.54 5.00
148 INT352268 Tnf Positive_regulation of Arl6ip6 1 0.02 2.42 0.54 5.00
149 INT281649 Negative_regulation of Binding of Calca and Trpv1 1 0.13 0.67 0.54 5.00
150 INT245558 Runx3 Regulation of Ngfr 1 0.06 1 0.53 5.00
151 INT245553 Runx1 Positive_regulation of Gene_expression of Ntrk1 2 0.45 1.41 0.52 5.00
152 INT262565 Prkaca Regulation of Negative_regulation of Trpv1 1 0.05 0.21 0.5 5.00
153 INT313376 Cnr1 Positive_regulation of Phosphorylation of Mapk14 1 0.20 0.38 0.5 5.00
154 INT172081 TNF Regulation of IFNA1 1 0.03 1.13 0.5 5.00
155 INT313375 Cnr2 Positive_regulation of Phosphorylation of Mapk14 1 0.18 0.39 0.5 5.00
156 INT313373 Cnr2 Positive_regulation of Gene_expression of Gfap 1 0.32 0.39 0.5 5.00
157 INT172082 TNF Regulation of SFTPA1 1 0.05 0.85 0.5 5.00
158 INT313371 Cnr1 Positive_regulation of Gene_expression of Gfap 1 0.35 0.39 0.5 5.00
159 INT301285 Binding of Tyrobp and Clec5a 1 0.32 1.63 0.49 5.00
160 INT263917 Binding of SST and Sstr5 2 0.02 0.56 0.45 5.00
161 INT262575 Trpv1 Positive_regulation of Prkca 1 0.13 0.17 0.44 5.00
162 INT313377 Trib3 Regulation of Gene_expression of Gfap 1 0.01 0.37 0.44 5.00
163 INT313378 Trib3 Regulation of Phosphorylation of Mapk14 1 0.01 0.37 0.44 5.00
164 INT313380 Binding of Cnr1 and Trpv1 1 0.36 0.09 0.39 5.00
165 INT208571 CCL21 Positive_regulation of Gene_expression of CCL16 1 0.51 0.63 0.38 5.00
166 INT254278 Binding of Il13 and Il4 1 0.02 0.74 0.38 5.00
167 INT297352 KLF2 Regulation of PPARA 1 0.12 1.31 0.35 5.00
168 INT297351 EWSR1 Positive_regulation of PPARA 1 0.41 1.81 0.33 5.00
169 INT210597 Negative_regulation of Binding of TNFSF11 and TNFRSF11A 3 0.26 5.66 0.33 5.00
170 INT311997 Regulation of STAM Regulation of BGLAP 1 0.00 0.61 0.32 5.00
171 INT222299 Binding of CYP19A1 and AIS 2 0.25 1.65 0.31 5.00
172 INT311991 STAM Regulation of BGLAP 1 0.00 0.61 0.31 5.00
173 INT313374 Cnr1 Regulation of Gene_expression of Cnr2 1 0.36 0 0.3 5.00
174 INT245563 Negative_regulation of Runx1 Regulation of Ret 1 0.39 0.76 0.29 5.00
175 INT245554 Tbx15 Positive_regulation of Gene_expression of Ntrk1 1 0.02 0.65 0.29 5.00
176 INT245556 Runx1 Regulation of Ret 1 0.56 0.76 0.29 5.00
177 INT301277 Il6 Positive_regulation of Positive_regulation of Clec5a 1 0.16 0.37 0.29 5.00
178 INT245562 Ntrk3 Regulation of Runx3 1 0.40 0.77 0.29 5.00
179 INT301287 Positive_regulation of Clec5a Positive_regulation of Gene_expression of Il6 1 0.14 0.58 0.29 5.00
180 INT220870 Timp3 Negative_regulation of Adamts4 1 0.03 0.15 0.27 5.00
181 INT220871 Timp3 Negative_regulation of Adamts1 1 0.01 0.15 0.27 5.00
182 INT301276 Il6 Positive_regulation of Gene_expression of Tnfrsf11a 1 0.06 0.37 0.26 5.00
183 INT257577 CALCA Positive_regulation of DMD 1 0.01 0.57 0.26 5.00
184 INT301280 Il6 Positive_regulation of Gene_expression of Acp5 1 0.04 0.37 0.26 5.00
185 INT301291 Il6 Positive_regulation of Gene_expression of TNF 1 0.01 0.37 0.26 5.00
186 INT254283 Il10 Negative_regulation of Nfatc1 1 0.02 0.31 0.25 5.00
187 INT245571 Runx1 Positive_regulation of Tbx15 Positive_regulation of Ntrk1 1 0.02 0.91 0.25 5.00
188 INT245557 Runx1 Positive_regulation of Gene_expression of Tbx15 1 0.02 0.75 0.25 5.00
189 INT245561 Gene_expression of Runx1 Positive_regulation of Gene_expression of Tbx15 1 0.02 0.8 0.25 5.00
190 INT239087 Binding of SST and Negative_regulation of Localization of GH1 1 0.19 0.36 0.24 5.00
191 INT245567 Tbx15 Positive_regulation of Ntrk1 1 0.02 0.9 0.24 5.00
192 INT297376 Binding of RARS and Rxra 1 0.01 3.27 0.24 5.00
193 INT245555 Runx1 Negative_regulation of Cdkn1a 1 0.29 1.17 0.23 5.00
194 INT245565 Runx1 Negative_regulation of Negative_regulation of Cdkn1a 1 0.29 1.17 0.23 5.00
195 INT250553 Binding of RS1 and SUGT1 3 0.00 3.36 0.22 5.00
196 INT270135 Binding of ESR1 and RALA 1 0.11 0.37 0.22 5.00
197 INT254281 Il4 Negative_regulation of Gene_expression of Acp5 1 0.02 0.41 0.22 5.00
198 INT172083 TNF Regulation of Regulation of IFNA1 1 0.03 0.91 0.22 5.00
199 INT301279 Tnfsf11 Regulation of Gene_expression of Mmp9 1 0.13 0.34 0.21 5.00
200 INT301281 Tnfsf11 Regulation of Gene_expression of Clec5a 1 0.22 0.34 0.21 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Bone Cancer. They are ordered first by their pain relevance and then by number of times they were reported in Bone Cancer. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT351355 Positive_regulation of Localization of Lpar1 1 0.25 3.94 2.87 100.00
2 INT97848 Positive_regulation of Localization of Trpv1 18 0.50 7.66 13.36 100.00
3 INT307095 Negative_regulation of Regulation of Prmt1 1 0.02 0.93 0.63 100.00
4 INT307096 Regulation of Prmt1 1 0.01 0.92 0.63 100.00
5 INT87686 Positive_regulation of Gene_expression of Trpv1 101 0.70 72.41 69.15 99.98
6 INT112539 Positive_regulation of Gene_expression of Hmgb1 2 0.70 3.55 2.95 99.98
7 INT83602 Positive_regulation of Gene_expression of TRPV1 114 0.70 51.19 56.35 99.98
8 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 99.98
9 INT93534 Gene_expression of Tnfsf11 185 0.77 119.26 33.66 99.96
10 INT78935 Localization of Cacna1c 3 0.48 1.25 0.97 99.96
11 INT21214 Negative_regulation of Gene_expression of PENK 21 0.58 9.14 9.53 99.96
12 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 99.96
13 INT48077 Positive_regulation of Localization of Il1b 17 0.69 8.8 7.68 99.90
14 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 99.86
15 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 99.86
16 INT93144 Gene_expression of CCR1 18 0.75 14.69 6.84 99.86
17 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 99.84
18 INT111948 Positive_regulation of Gria1 23 0.61 7.55 12.03 99.84
19 INT211970 Negative_regulation of Best1 49 0.14 37.33 2.32 99.84
20 INT63341 Negative_regulation of ICAM1 42 0.59 30.45 9.5 99.84
21 INT89054 Positive_regulation of Gene_expression of Trpv1 156 0.70 90.78 102.03 99.82
22 INT112541 Gene_expression of Hmgb1 2 0.78 4.75 3.8 99.82
23 INT65733 Positive_regulation of Cnr1 125 0.70 40.27 67.33 99.82
24 INT87932 Positive_regulation of Gene_expression of Cnr1 28 0.69 8.86 16.38 99.82
25 INT132887 Positive_regulation of Phosphorylation of Grin1 3 0.49 1.73 3.08 99.82
26 INT64202 Positive_regulation of Trpv1 643 0.70 249.66 397.42 99.80
27 INT351354 Localization of Lpar1 1 0.40 6.93 5.05 99.80
28 INT5317 Positive_regulation of PGE 24 0.46 8.27 5.49 99.80
29 INT34904 Negative_regulation of Gtf3a 48 0.15 38.88 13.73 99.80
30 INT80408 Negative_regulation of Prkcb 3 0.14 2.17 1.88 99.80
31 INT10824 Negative_regulation of Cyp19a1 38 0.57 25.18 3.56 99.80
32 INT58061 Gene_expression of Trpv1 1117 0.78 451.54 637.59 99.78
33 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42 99.78
34 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81 99.78
35 INT80075 Regulation of Gene_expression of Trpv1 55 0.62 32.42 36.88 99.78
36 INT351356 Positive_regulation of Gene_expression of Lpar1 1 0.35 1.98 1.41 99.76
37 INT64918 Gene_expression of Gria2 108 0.74 29.95 29.67 99.74
38 INT151120 Negative_regulation of Tlr4 18 0.59 21.09 14.46 99.72
39 INT295467 Negative_regulation of Gene_expression of Tlr4 11 0.58 7.94 6.83 99.72
40 INT118734 Gene_expression of Tlr4 70 0.78 55.7 28.19 99.68
41 INT146991 Positive_regulation of Gene_expression of Tlr4 21 0.69 20.76 8.69 99.68
42 INT118742 Positive_regulation of Tlr4 32 0.69 27.55 11.09 99.68
43 INT205198 Positive_regulation of Lpar1 2 0.35 7.35 6.37 99.68
44 INT161529 Regulation of Gene_expression of Tlr4 3 0.45 2.7 0.69 99.68
45 INT66198 Negative_regulation of Gene_expression of Gfap 13 0.59 10.33 3.41 99.68
46 INT66200 Gene_expression of Gfap 215 0.78 88.04 28.25 99.68
47 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 99.64
48 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26 99.64
49 INT22083 Regulation of Pth 55 0.62 22.32 8.9 99.64
50 INT62067 Negative_regulation of Gene_expression of Pth 13 0.41 8.24 0.61 99.64
51 INT2289 Gene_expression of PENK 203 0.78 55.62 79.49 99.64
52 INT5319 Positive_regulation of PTGFR 9 0.32 4.96 1.44 99.64
53 INT7056 Positive_regulation of Gene_expression of PENK 35 0.70 14.31 18.21 99.64
54 INT279122 Regulation of Gene_expression of COMP 3 0.39 8.82 3.19 99.64
55 INT279119 Regulation of Gene_expression of MATN3 1 0.45 0.83 0 99.64
56 INT170646 Negative_regulation of Fig4 213 0.37 81.29 46.92 99.62
57 INT121987 Phosphorylation of Grin1 11 0.80 4.73 8.88 99.62
58 INT205203 Gene_expression of Lpar1 6 0.39 11.83 8.08 99.52
59 INT25363 Negative_regulation of Trpv1 144 0.59 64.78 75.7 99.52
60 INT295469 Localization of Tlr4 3 0.75 2.22 1.88 99.52
61 INT205609 Negative_regulation of Gm6668 1 0.01 0.75 0 99.52
62 INT131408 Positive_regulation of Negative_regulation of Bdkrb1 1 0.49 1.7 1.32 99.48
63 INT101225 Positive_regulation of Gria2 62 0.64 28.1 23.93 99.48
64 INT170351 Positive_regulation of Gene_expression of Gria2 13 0.67 3.67 3.27 99.48
65 INT5596 Negative_regulation of Gene_expression of Pdyn 41 0.59 5.34 24.36 99.48
66 INT3179 Positive_regulation of SCT 15 0.50 4.79 1.98 99.48
67 INT65731 Gene_expression of Cnr1 234 0.78 63.82 109.34 99.40
68 INT68708 Negative_regulation of RHCE 4 0.26 2.53 0.48 99.40
69 INT107575 Positive_regulation of Gene_expression of Atf3 25 0.69 27.37 14.55 99.38
70 INT129157 Positive_regulation of Atf3 48 0.69 35.42 22.87 99.38
71 INT129156 Positive_regulation of Sf3a3 9 0.08 10.89 7.01 99.38
72 INT149349 Regulation of Atf3 8 0.45 10 3.85 99.36
73 INT48081 Localization of Il1b 46 0.80 21.59 22.4 99.36
74 INT6624 Gene_expression of Pth 135 0.76 110.27 27.54 99.34
75 INT118741 Transcription of Cd14 3 0.66 3.32 2.57 99.32
76 INT68913 Gene_expression of Cd14 55 0.76 38.99 15.67 99.32
77 INT99163 Positive_regulation of Cd14 18 0.49 16.02 7.91 99.32
78 INT92821 Positive_regulation of Gene_expression of Cd14 15 0.66 9.82 4.5 99.32
79 INT118739 Positive_regulation of Transcription of Cd14 2 0.64 1.11 0.94 99.32
80 INT87687 Positive_regulation of Trpv1 409 0.70 210.24 257.59 99.28
81 INT1168 Binding of PROC 62 0.38 44.15 9.04 99.28
82 INT6625 Negative_regulation of Pth 96 0.58 57.6 8.24 99.24
83 INT5597 Gene_expression of Pdyn 433 0.78 62.97 235.47 99.24
84 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 99.20
85 INT52464 Negative_regulation of Bdkrb1 9 0.57 8.71 5.87 99.20
86 INT168279 Regulation of Tlr4 17 0.54 8.97 5.5 99.20
87 INT9347 Localization of Il1b 58 0.81 26.13 31.53 99.18
88 INT82829 Gene_expression of COMP 104 0.78 57 9.81 99.16
89 INT143276 Phosphorylation of Gria2 42 0.80 16.07 15.2 99.14
90 INT96917 Positive_regulation of Mapk14 261 0.70 173.29 88.79 99.12
91 INT6481 Binding of TNF 624 0.48 510.2 214.82 99.10
92 INT6478 Negative_regulation of Binding of TNF 36 0.58 30.42 13.31 99.10
93 INT93532 Regulation of Tnfsf11 14 0.42 10.75 2.39 99.04
94 INT89045 Negative_regulation of P2RX2 4 0.41 2.75 2.88 99.04
95 INT3824 Negative_regulation of PTH 40 0.59 28.58 3.39 99.04
96 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 99.00
97 INT9381 Positive_regulation of TRPV1 523 0.70 187.4 276.05 99.00
98 INT236487 Positive_regulation of Gene_expression of Grina 2 0.08 1.77 1.45 99.00
99 INT93451 Positive_regulation of Gene_expression of Grin2b 43 0.70 29.09 31.89 99.00
100 INT131844 Gene_expression of MATN3 12 0.78 9.65 0.92 99.00
101 INT17701 Gene_expression of PTHLH 103 0.78 64.23 8.85 98.98
102 INT118740 Transcription of Itgam 5 0.70 5.11 4.14 98.96
103 INT118735 Positive_regulation of Transcription of Itgam 2 0.49 4.24 3.11 98.96
104 INT66025 Gene_expression of Itgam 61 0.78 31.26 26.08 98.96
105 INT108098 Positive_regulation of Itgam 19 0.70 8.09 8.86 98.96
106 INT88077 Localization of Tnfrsf11b 4 0.80 5.22 3.22 98.90
107 INT129158 Gene_expression of Sf3a3 5 0.13 6.47 3.67 98.88
108 INT103300 Negative_regulation of Gene_expression of CRTAC1 3 0.44 2.87 0.7 98.88
109 INT102638 Regulation of VDR 21 0.44 9.92 2.54 98.88
110 INT49520 Gene_expression of P2rx3 121 0.78 61.15 49.24 98.86
111 INT38731 Localization of Trpv1 138 0.81 52.73 90.49 98.84
112 INT62071 Positive_regulation of Gene_expression of PTHLH 13 0.70 19.32 1.73 98.84
113 INT92518 Gene_expression of Grin2b 131 0.78 65.52 80.91 98.80
114 INT14126 Gene_expression of Grina 13 0.67 4.63 4.57 98.80
115 INT261611 Localization of DEL15Q24 1 0.02 0.79 0.06 98.80
116 INT78879 Positive_regulation of EWSR1 4 0.50 2.97 0.47 98.80
117 INT158696 Regulation of Ewsr1 1 0.40 0.7 0.08 98.78
118 INT54571 Positive_regulation of NFKB1 263 0.70 138.99 87.32 98.72
119 INT78579 Negative_regulation of P2rx3 23 0.59 10.13 10.78 98.68
120 INT89048 Gene_expression of P2RX2 28 0.75 8.75 7.9 98.68
121 INT107576 Gene_expression of Atf3 114 0.78 72.42 38.64 98.68
122 INT50972 Negative_regulation of Ntrk1 39 0.51 32.22 17.29 98.66
123 INT162782 Regulation of Tnfrsf11b 2 0.24 2.09 0.18 98.64
124 INT158123 Negative_regulation of Gene_expression of COL5A2 19 0.46 15.27 2.23 98.62
125 INT151099 Negative_regulation of CFTR 12 0.59 10.28 3.79 98.60
126 INT22066 Gene_expression of Phax 40 0.78 22.51 25.91 98.52
127 INT266828 Negative_regulation of Fgf23 3 0.42 5.63 0.04 98.52
128 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 98.48
129 INT6512 Gene_expression of PTH 103 0.77 76.29 6.33 98.48
130 INT53927 Positive_regulation of Localization of PTH 8 0.69 5.33 0.09 98.48
131 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59 98.48
132 INT4860 Positive_regulation of CALCA 148 0.00 73.35 97.61 98.48
133 INT23463 Positive_regulation of Gene_expression of CALCA 47 0.70 18.14 28.76 98.48
134 INT330532 Binding of Ckds 1 0.00 1.23 0 98.48
135 INT20055 Gene_expression of CRTAC1 19 0.58 15.49 4.73 98.46
136 INT97368 Negative_regulation of Nav1 62 0.59 41.56 60.27 98.44
137 INT30738 Negative_regulation of Gene_expression of ALB 32 0.59 19.01 5.04 98.32
138 INT79234 Positive_regulation of CCL3 15 0.67 11.43 4.15 98.32
139 INT138690 Negative_regulation of ENO3 1 0.20 0.75 0.09 98.28
140 INT185284 Binding of CDK4 7 0.25 4.79 0.07 98.28
141 INT5895 Gene_expression of Oprm1 525 0.78 120.67 407.29 98.24
142 INT53525 Positive_regulation of NXT1 11 0.35 4.81 2.41 98.24
143 INT134646 Gene_expression of Tnfsf11 19 0.69 14.77 4.16 98.24
144 INT294998 Positive_regulation of Gene_expression of Tnfsf11 5 0.62 2.98 0.79 98.24
145 INT117204 Gene_expression of Tcm 39 0.58 10.58 4.88 98.20
146 INT16167 Negative_regulation of DMD 186 0.57 108.71 15.25 98.18
147 INT64201 Negative_regulation of Trpv1 203 0.59 79.18 119.75 98.16
148 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 98.16
149 INT114018 Binding of CD200 5 0.47 2.12 0.52 98.14
150 INT68269 Gene_expression of CD99 49 0.77 47.38 3.86 98.12
151 INT152223 Binding of BEST1 10 0.29 6.67 1.46 98.12
152 INT301267 Binding of Clec5a 2 0.37 1.17 0.35 98.12
153 INT209424 Binding of Tyrobp 5 0.43 2.03 0.33 98.12
154 INT2544 Localization of PTH 39 0.81 30.55 2.22 98.08
155 INT134889 Negative_regulation of TNFRSF11A 9 0.42 12.65 1.76 98.08
156 INT107525 Positive_regulation of Faah 5 0.60 1.54 2.78 98.08
157 INT128587 Localization of Mapk14 15 0.81 8.41 6.1 98.08
158 INT6852 Localization of TNF 883 0.81 705.95 270.84 98.00
159 INT144430 Gene_expression of Erbb2 137 0.77 103.87 8.66 98.00
160 INT209435 Regulation of Tyrobp 2 0.40 1.55 0.37 97.96
161 INT244657 Regulation of Lch 3 0.40 6.63 0.13 97.92
162 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 97.88
163 INT119729 Binding of Tnfsf11 31 0.35 24.02 7.45 97.84
164 INT297804 Regulation of Lrp5 6 0.60 2.31 0.27 97.84
165 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 97.76
166 INT111156 Negative_regulation of Dkk1 21 0.58 20.08 4.27 97.76
167 INT163500 Transcription of Grin2b 3 0.67 3.63 3.8 97.76
168 INT110633 Binding of Nav1 15 0.42 4.34 9.38 97.72
169 INT167657 Localization of Hmgb1 3 0.75 3.48 1.67 97.68
170 INT2867 Gene_expression of CALCA 247 0.78 78.78 138.47 97.68
171 INT153814 Localization of LPA 19 0.65 18.25 7.68 97.64
172 INT93016 Binding of TNFRSF11A 29 0.47 19.67 4.17 97.64
173 INT158124 Gene_expression of COL5A2 136 0.69 72.3 12.44 97.64
174 INT56448 Regulation of ICAM1 52 0.60 55.1 10.96 97.60
175 INT219876 Positive_regulation of PHPT1 1 0.01 1.25 0 97.56
176 INT13938 Positive_regulation of Nkx1-1 64 0.68 30.83 58.75 97.52
177 INT144490 Regulation of Gene_expression of Tnfsf11 14 0.58 14.09 2.39 97.48
178 INT162781 Positive_regulation of Tnfrsf11b 5 0.27 1.91 0.09 97.48
179 INT137846 Regulation of Tnfsf11 5 0.48 1.62 0.42 97.48
180 INT22715 Positive_regulation of Gene_expression of Pth 29 0.64 22.53 2.31 97.40
181 INT167180 Phosphorylation of TNFRSF11A 1 0.79 1.03 0.09 97.36
182 INT207735 Negative_regulation of TPM1 3 0.57 2.77 0.83 97.32
183 INT78877 Gene_expression of EWSR1 10 0.75 11.16 0.97 97.28
184 INT110854 Phosphorylation of Egf 8 0.75 5.62 0.67 97.24
185 INT225248 Positive_regulation of Phosphorylation of Egf 2 0.32 2.02 0.34 97.24
186 INT125627 Gene_expression of TTF1 11 0.78 12.68 0.78 97.20
187 INT113346 Binding of MDM2 10 0.35 5.73 0.15 97.16
188 INT93533 Positive_regulation of Tnfsf11 53 0.50 36.93 10.53 97.14
189 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 97.12
190 INT143945 Localization of EWSR1 5 0.78 3.39 0.06 97.04
191 INT20129 Regulation of Il1 53 0.53 44.14 19.89 97.00
192 INT70673 Regulation of IL11 5 0.45 2.89 1.2 97.00
193 INT9660 Regulation of TNF 363 0.62 312.94 139.99 97.00
194 INT159643 Regulation of Gan 3 0.25 3.02 1.2 96.96
195 INT219927 Regulation of Prtg 1 0.13 0.65 0.13 96.96
196 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 96.92
197 INT181604 Localization of WT1 1 0.63 1.41 0.03 96.88
198 INT95668 Positive_regulation of Tnfrsf11a 12 0.47 10.14 1.34 96.86
199 INT103914 Phosphorylation of Egfr 35 0.82 16.98 4.31 96.76
200 INT169756 Binding of CFTR 9 0.35 9.65 4.55 96.72
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