D:Bradycardia

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Disease Term
Synonyms BRADYARRHYTHMIA, BRADYARRHYTHMIAS, Bradycardia Pulse, BRADYCARDIAS, Cardiac Arrhythmia Bradycardia, Decreased Heart Rate, Decreased Pulse Rate, Heart Rate Low, Heart Rate Slow, Heartbeat Slow Pulse, PULSE DECREASED
Documents 375
Hot Single Events 98
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Bradycardia. They are ordered first by their relevance to Bradycardia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT28845 su Negative_regulation of Positive_regulation of Scn2a1 1 0.27 1.27 0.61 99.74
2 INT36733 Positive_regulation of Prn Negative_regulation of Gene_expression of Mtap 1 0.16 0.44 0.28 92.60
3 INT214015 Negative_regulation of Binding of Dnahc8 and Ank2 1 0.04 1.09 0.04 78.60
4 INT214013 Binding of Dnahc8 and Ank2 1 0.03 1.08 0.04 77.96
5 INT66535 Binding of Pnoc and Oprl1 43 0.54 5.93 32.4 76.56
6 INT70270 Binding of ADRA2B and Pnoc 2 0.02 0.15 1.08 76.08
7 INT199734 Binding of PRB1 and REN 1 0.01 0.08 0 45.04
8 INT214012 Binding of Ank1 and Nav1 1 0.01 0.51 0.1 43.52
9 INT214011 Negative_regulation of Binding of Ank1 and Nav1 1 0.01 0.51 0.1 43.52
10 INT214014 Binding of Dysf and Nav1 1 0.00 0.5 0.1 42.08
11 INT214016 Dysf Negative_regulation of Binding of Dysf and Nav1 1 0.00 0.5 0.1 42.08
12 INT16677 Binding of Avp and Oprd1 1 0.02 0.8 0.47 41.36
13 INT297393 TRIM6-TRIM34 Regulation of CRH 1 0.01 1.42 0.19 5.00
14 INT293712 Binding of Adra2a and Atl1 1 0.06 0.83 0.15 5.00
15 INT353318 NOS1 Positive_regulation of Localization of Tbxa2r 1 0.04 0.71 0.12 5.00
16 INT241040 Slc8a1 Negative_regulation of Gene_expression of Ca2 1 0.15 1.35 0.09 5.00
17 INT353314 Edn1 Positive_regulation of Kalrn 1 0.03 0.21 0.04 5.00
18 INT353317 Edn1 Positive_regulation of RHOA 1 0.19 0.16 0.04 5.00
19 INT302908 Agtr2 Positive_regulation of Gene_expression of Agt 1 0.00 0.22 0.03 5.00
20 INT302909 Nav2 Positive_regulation of Arhgef16 1 0.02 0.52 0 5.00
21 INT199733 PRB1 Regulation of REV1 1 0.01 0 0 5.00
22 INT242674 Binding of Pde6b and Ppp3cb 1 0.00 0.6 0 5.00
23 INT199735 PRB1 Regulation of TCFL5 1 0.02 0 0 5.00
24 INT353316 Prkg1 Positive_regulation of Phosphorylation of PRKG1 1 0.00 0.06 0 5.00
25 INT277766 EGFR Regulation of Gene_expression of VEGFA 1 0.54 0.14 0 5.00
26 INT199736 PRB1 Regulation of DHX9 1 0.00 0 0 5.00
27 INT277772 Binding of EGFR and fc 1 0.01 0.57 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Bradycardia. They are ordered first by their pain relevance and then by number of times they were reported in Bradycardia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT660 Negative_regulation of REN 194 0.59 82.06 29.46 100.00
2 INT28857 Negative_regulation of Positive_regulation of Pag1 11 0.30 8.46 10.19 100.00
3 INT9832 Gene_expression of Shbg 96 0.75 56.71 12.19 100.00
4 INT21933 Regulation of Negative_regulation of Pag1 5 0.28 5.48 5.29 100.00
5 INT10170 Negative_regulation of Ns5atp9 14 0.55 3.99 3.18 100.00
6 INT38285 Positive_regulation of SCLY 8 0.36 3.32 3.96 100.00
7 INT194546 Positive_regulation of Gene_expression of Dbp 9 0.28 2.93 0.36 100.00
8 INT169347 Positive_regulation of Gene_expression of SCLY 1 0.07 0.65 0.06 100.00
9 INT21103 Gene_expression of Dbp 48 0.61 22.6 5.59 100.00
10 INT29231 Regulation of Dbp 44 0.53 10.08 4.47 100.00
11 INT22798 Regulation of Shbg 64 0.60 26.71 8.76 100.00
12 INT66417 Localization of Pnoc 34 0.80 1.61 24.48 100.00
13 INT2660 Negative_regulation of Fabp6 58 0.49 33.74 18.27 100.00
14 INT10104 Negative_regulation of Edn1 43 0.59 15.63 7.2 100.00
15 INT2592 Positive_regulation of Negative_regulation of REN 3 0.24 0.34 0.64 100.00
16 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 99.96
17 INT1665 Positive_regulation of Pag1 270 0.68 186.63 229.87 99.92
18 INT28844 Negative_regulation of Scn2a1 15 0.37 3.84 3.65 99.84
19 INT8637 Negative_regulation of Dbp 112 0.50 33.28 8.4 99.80
20 INT65078 Negative_regulation of Pnoc 64 0.59 15.48 59.81 99.80
21 INT904 Positive_regulation of Ptgfr 23 0.49 7.98 5.55 99.80
22 INT2630 Positive_regulation of Shbg 134 0.70 65.26 15.19 99.76
23 INT114741 Binding of PRB1 19 0.36 5.44 1 99.76
24 INT169348 Gene_expression of SCLY 8 0.11 6.49 1.33 99.74
25 INT57150 Regulation of SCLY 3 0.45 4.2 1.12 99.74
26 INT3602 Negative_regulation of Shbg 148 0.53 69.05 11.65 99.60
27 INT25834 Positive_regulation of Dbp 59 0.68 24.34 9.32 99.56
28 INT28843 Positive_regulation of Scn2a1 31 0.68 5.35 10.7 99.48
29 INT3835 Positive_regulation of su 10 0.62 4.04 6.19 99.48
30 INT10924 Positive_regulation of Sysbp1 25 0.04 11.12 7.35 99.42
31 INT9304 Negative_regulation of Pag1 70 0.39 51.97 64.23 99.40
32 INT5136 Negative_regulation of PDYN 71 0.59 11.22 51.14 99.32
33 INT241036 Regulation of Slc8a1 5 0.22 3.43 0.37 98.84
34 INT37968 Negative_regulation of Pvrl2 1 0.13 0.87 1.12 98.60
35 INT73611 Negative_regulation of SCD 15 0.37 26.67 3.71 98.56
36 INT4207 Regulation of Avp 267 0.62 63.72 115.33 97.84
37 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 97.80
38 INT214005 Gene_expression of Ank2 1 0.78 29.4 1.88 97.68
39 INT119498 Positive_regulation of Pde6b 11 0.43 18.75 4.22 97.48
40 INT35767 Negative_regulation of Positive_regulation of D5Nam12 1 0.34 0.54 0.26 97.44
41 INT36727 Positive_regulation of Prn 1 0.41 1.18 0.81 97.32
42 INT35768 Positive_regulation of D5Nam12 1 0.36 0.54 0.26 97.12
43 INT484 Negative_regulation of ADRB2 13 0.59 2.85 3.94 96.92
44 INT40832 Localization of ADRB2 5 0.73 2.21 1.81 96.92
45 INT40833 Negative_regulation of Localization of ADRB2 2 0.40 0.58 0.38 96.92
46 INT653 Negative_regulation of Localization of REN 67 0.59 20.33 16.7 96.32
47 INT7781 Regulation of Ap2m1 3 0.60 0.26 1.9 96.32
48 INT654 Localization of REN 250 0.81 75.12 47.86 96.00
49 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 95.24
50 INT4336 Negative_regulation of Gene_expression of REN 13 0.58 7.22 1.43 94.64
51 INT661 Gene_expression of REN 100 0.78 48.21 11.36 94.04
52 INT10863 Positive_regulation of Ldlr 45 0.68 31.06 7.05 94.04
53 INT1395 Negative_regulation of Penk 537 0.59 87.33 389.81 94.00
54 INT797 Regulation of Penk 812 0.62 111.13 542.24 94.00
55 INT10056 Positive_regulation of Fabp6 77 0.59 36.99 16.8 93.60
56 INT12392 Regulation of Slc3a1 45 0.36 7.57 25.66 93.16
57 INT13989 Negative_regulation of Slc3a1 27 0.24 5.34 16.76 93.16
58 INT36729 Negative_regulation of Positive_regulation of Prn 1 0.25 0.43 0.28 92.60
59 INT4521 Positive_regulation of PBOV1 4 0.02 1.18 0.24 92.56
60 INT4519 Negative_regulation of Positive_regulation of PBOV1 2 0.01 0.4 0.2 92.56
61 INT2978 Gene_expression of Tbxa2r 76 0.77 28.4 21.27 92.32
62 INT36730 Negative_regulation of Mtap 1 0.24 0.5 0.52 91.72
63 INT1734 Negative_regulation of HSD11B1 116 0.57 125.13 10.52 91.48
64 INT4520 Negative_regulation of PBOV1 1 0.01 0.33 0.15 91.44
65 INT36728 Gene_expression of Mtap 1 0.33 0.51 0.52 91.12
66 INT14546 Positive_regulation of Localization of Ca2 93 0.67 31.09 18.72 90.56
67 INT11302 Regulation of Mtap 3 0.22 1.2 0.91 90.08
68 INT36880 Negative_regulation of PRB1 9 0.37 1.37 0.38 90.04
69 INT105803 Regulation of IHG1 1 0.24 0.44 1 89.92
70 INT4822 Localization of Ca2 417 0.80 99.57 96.45 89.48
71 INT5940 Negative_regulation of Avp 236 0.59 67.86 101.2 89.44
72 INT58602 Gene_expression of HMI 34 0.65 25.26 3.74 89.32
73 INT443 Localization of POMC 1020 0.81 284.52 443.17 89.04
74 INT1197 Negative_regulation of Localization of POMC 109 0.59 28.29 48.02 89.04
75 INT36732 Regulation of Gene_expression of Prn 1 0.23 0.26 0.27 88.72
76 INT75919 Gene_expression of Slc8a1 23 0.63 16.44 9.84 88.68
77 INT796 Gene_expression of Penk 1902 0.78 275.47 1057.59 88.32
78 INT4358 Positive_regulation of Localization of Avp 195 0.70 30.79 77.58 88.20
79 INT112387 Positive_regulation of Rnf103 1 0.38 0.38 0.92 88.12
80 INT1108 Gene_expression of PPY 58 0.75 36.57 10.76 88.08
81 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77 87.68
82 INT477 Localization of Avp 813 0.81 131.58 300.4 87.52
83 INT36731 Gene_expression of Prn 3 0.35 2.05 0.36 87.52
84 INT14124 Negative_regulation of Adra1a 34 0.59 7.48 10.85 87.40
85 INT937 Positive_regulation of Oxt 195 0.70 37.82 49.3 87.28
86 INT298 Negative_regulation of ADRB3 23 0.59 6.82 7.56 86.76
87 INT43441 Binding of Hps4 7 0.24 0.46 7.43 86.36
88 INT1261 Localization of Adh1 63 0.81 19.36 16.09 84.20
89 INT66527 Positive_regulation of Npy2r 2 0.31 0.47 1.44 84.20
90 INT72350 Positive_regulation of Npy1r 15 0.63 6.28 6.55 84.20
91 INT86646 Positive_regulation of SCN10A 71 0.69 50.61 13.24 83.60
92 INT5458 Negative_regulation of Tbxa2r 31 0.54 10.58 8.89 81.68
93 INT19639 Negative_regulation of Gene_expression of Tbxa2r 17 0.55 7.69 5.01 81.68
94 INT12608 Regulation of CNR1 62 0.60 24.36 36.02 81.60
95 INT97807 Negative_regulation of Regulation of CNR1 2 0.09 0.89 2.51 81.60
96 INT209753 Binding of Tro 2 0.31 1.27 0.45 80.48
97 INT214009 Positive_regulation of Gene_expression of Ank2 1 0.70 2.86 0 80.20
98 INT33717 Regulation of Localization of Adh1 15 0.54 3.3 2.91 80.08
99 INT68337 Regulation of RNLS 2 0.45 0.74 1.3 78.88
100 INT37969 Positive_regulation of Pvrl2 1 0.14 0.48 0.76 77.84
101 INT4438 Negative_regulation of Localization of Adh1 18 0.59 6.23 6.95 77.28
102 INT4598 Negative_regulation of Adh1 15 0.54 4.69 5.33 77.28
103 INT213995 Positive_regulation of Ank2 1 0.50 2.86 0 77.08
104 INT338494 Localization of RNLS 1 0.79 1.84 0.46 76.88
105 INT33431 Localization of Dnahc8 8 0.67 3.49 1.68 76.56
106 INT214002 Localization of Slc8a1 1 0.34 1.07 0.04 76.24
107 INT2540 Negative_regulation of Calca 538 0.59 172.11 384.38 75.92
108 INT480 Negative_regulation of Localization of Avp 151 0.59 27.64 63.72 75.92
109 INT36040 Localization of Itpr3 21 0.70 4.87 7.77 75.40
110 INT4735 Gene_expression of Acot1 80 0.71 13.22 26.68 75.00
111 INT48008 Negative_regulation of Pde6b 9 0.15 6.12 4.11 74.64
112 INT173576 Negative_regulation of FDPS 25 0.57 8.42 1.91 74.28
113 INT2140 Regulation of REN 104 0.62 28.24 24.49 73.08
114 INT2451 Positive_regulation of Avp 355 0.70 102.66 147.69 72.96
115 INT1456 Regulation of Oprl1 61 0.62 19.5 52.87 72.64
116 INT214007 Negative_regulation of Ank2 1 0.43 2.63 0.14 71.64
117 INT13227 Regulation of Ns5atp9 9 0.61 3.51 3.92 69.48
118 INT9748 Negative_regulation of Sysbp1 28 0.35 8.93 3.87 69.04
119 INT19603 Gene_expression of Sysbp1 4 0.15 0.55 1.49 69.04
120 INT9764 Gene_expression of Adrb3 10 0.62 4.14 2.33 68.52
121 INT1033 Positive_regulation of Ca2 507 0.68 131.76 147.64 66.96
122 INT213997 Negative_regulation of Gene_expression of Ank2 1 0.43 5.06 0.22 65.44
123 INT84572 Gene_expression of Zmat3 67 0.07 37.61 5.86 62.76
124 INT214008 Negative_regulation of Ank1 4 0.03 1.49 0.09 62.40
125 INT6067 Positive_regulation of Positive_regulation of Oprd1 37 0.69 6.56 36.58 62.20
126 INT4941 Positive_regulation of Oprd1 345 0.70 74.26 304.41 61.56
127 INT142491 Positive_regulation of Positive_regulation of SCN10A 6 0.61 3.48 0.35 61.16
128 INT62374 Gene_expression of NGF 158 0.78 77.87 76.45 58.08
129 INT84924 Positive_regulation of Gene_expression of NGF 29 0.68 17.91 16.46 58.08
130 INT214 Localization of AVP 370 0.81 208.51 91.09 57.60
131 INT6127 Regulation of Localization of AVP 60 0.62 15.12 20.84 57.60
132 INT685 Regulation of AVP 124 0.62 34.9 39.91 57.28
133 INT16676 Regulation of Negative_regulation of Avp 2 0.45 1.03 0.75 57.04
134 INT169322 Positive_regulation of Mylk 1 0.47 0.23 0.08 53.60
135 INT65187 Positive_regulation of PNN 2 0.02 1.12 0.77 53.24
136 INT1596 Negative_regulation of Oprl1 61 0.57 13.5 38.41 52.68
137 INT7608 Positive_regulation of Adra2a 66 0.70 17.81 35.15 52.48
138 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 50.28
139 INT8684 Positive_regulation of ANGPTL5 45 0.69 36.29 7.47 50.28
140 INT1080 Negative_regulation of Ache 343 0.59 108.51 72.4 49.12
141 INT29411 Positive_regulation of ADRB2 13 0.65 5.42 8.78 46.96
142 INT3533 Binding of REN 24 0.37 10.84 2.16 45.04
143 INT4937 Negative_regulation of Oprd1 224 0.59 44.51 171.11 42.08
144 INT46 Localization of Ren 233 0.81 46.15 62.44 40.24
145 INT50 Negative_regulation of Localization of Ren 87 0.59 14.94 30.22 40.24
146 INT241037 Regulation of Col3a1 2 0.05 1.94 0.14 39.68
147 INT338501 Gene_expression of RNLS 1 0.77 3.74 1.44 35.60
148 INT894 Binding of Avp 84 0.48 29.16 29.63 33.44
149 INT36400 Regulation of SCN10A 7 0.62 2.73 1.97 33.44
150 INT251742 Regulation of Positive_regulation of SCN10A 1 0.27 1.37 0.06 33.44
151 INT134902 Positive_regulation of Tymp 11 0.37 3.06 0.53 32.04
152 INT67719 Positive_regulation of Col1a1 21 0.44 8.87 3.12 27.44
153 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42 26.72
154 INT66416 Regulation of Pnoc 66 0.61 17.32 68.91 26.40
155 INT7059 Regulation of Adra2a 89 0.62 18.24 48.43 25.00
156 INT10285 Binding of ADRA1D 102 0.47 25.82 31.11 25.00
157 INT7779 Negative_regulation of Adra2a 47 0.58 9.45 28 25.00
158 INT50227 Positive_regulation of Adora2a 32 0.50 5.17 12.75 25.00
159 INT73101 Regulation of RT1-Hb-ps1 3 0.09 4.73 1.25 23.68
160 INT302907 Transcription of Nav2 1 0.72 0.85 0.03 19.60
161 INT351955 Gene_expression of Tro 1 0.44 1.38 0.33 16.08
162 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 9.68
163 INT2005 Positive_regulation of Gene_expression of PRL 55 0.70 21.4 13.44 9.68
164 INT53733 Positive_regulation of FGFR3 6 0.45 1.32 2.76 9.68
165 INT330397 Positive_regulation of Gene_expression of FGFR3 1 0.14 0.2 0.16 9.68
166 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 8.88
167 INT36314 Gene_expression of FGFR3 11 0.73 6.21 2.23 8.88
168 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
169 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
170 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
171 INT87687 Positive_regulation of Trpv1 409 0.70 210.24 257.59 5.00
172 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
173 INT1114 Localization of Ins1 748 0.80 192.95 165.48 5.00
174 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 5.00
175 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57 5.00
176 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 5.00
177 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 5.00
178 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
179 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 5.00
180 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 5.00
181 INT1472 Positive_regulation of Ins1 349 0.69 146.2 86.36 5.00
182 INT2520 Negative_regulation of Ca2 271 0.57 72.13 83.71 5.00
183 INT9382 Regulation of TRPV1 149 0.62 53.99 77.46 5.00
184 INT3657 Gene_expression of Ins1 514 0.78 321.69 75.76 5.00
185 INT171145 Positive_regulation of Fig4 274 0.59 93.55 69.81 5.00
186 INT13286 Gene_expression of Ca2 317 0.67 71.58 65.01 5.00
187 INT10706 Regulation of Il6 150 0.62 93.23 62.34 5.00
188 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
189 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 5.00
190 INT2276 Regulation of Ins1 234 0.61 103.78 54.05 5.00
191 INT1032 Regulation of Ca2 202 0.52 54.91 53.03 5.00
192 INT170646 Negative_regulation of Fig4 213 0.37 81.29 46.92 5.00
193 INT2275 Negative_regulation of Localization of Ins1 183 0.59 51.02 44.94 5.00
194 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
195 INT98498 Binding of Trpv1 75 0.48 33.67 44.4 5.00
196 INT1474 Regulation of Localization of Ins1 132 0.61 25.96 43.07 5.00
197 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
198 INT2531 Positive_regulation of Cebpz 166 0.00 43.08 38.86 5.00
199 INT14009 Gene_expression of Sst 66 0.77 19.6 37.3 5.00
200 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19 5.00
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