D:Brain Death

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Disease Term
Synonyms Brain Dead, Brain Deads, Coma Depasse, Coma Irreversible, Death Brain, IRREVERSIBLE COMA
Documents 174
Hot Single Events 32
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Brain Death. They are ordered first by their relevance to Brain Death and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT202963 Binding of STC2 and CPP 1 0.02 5.16 2.04 82.24
2 INT202965 Binding of STC2 and BAG3 1 0.02 7.86 2.96 28.64
3 INT202959 Binding of BAG3 and MCRS1 1 0.11 7.46 3.14 24.64
4 INT202974 Binding of BAG3 and CPP 1 0.25 6.22 2.73 24.64
5 INT202961 MCRS1 Negative_regulation of STC2 1 0.00 1.63 0.57 17.36
6 INT202967 MCRS1 Negative_regulation of CPP 2 0.14 2.2 0.73 16.80
7 INT202972 Positive_regulation of MCRS1 Negative_regulation of CPP 1 0.16 1.64 0.57 16.80
8 INT202957 CPP Negative_regulation of MCRS1 1 0.14 1.53 0.51 9.12
9 INT102160 Binding of Mmp2 and Mmp9 3 0.28 2.87 1.75 5.00
10 INT182097 Binding of Il6 and Il1 4 0.07 4.67 1.55 5.00
11 INT202958 Binding of STC2 and MCRS1 1 0.01 3.48 1.44 5.00
12 INT182096 Positive_regulation of Binding of Il6 and Il1 2 0.09 4.26 1.31 5.00
13 INT202960 Binding of MCRS1 and CPP 1 0.14 2.49 1.13 5.00
14 INT202968 Binding of MCRS1 and CAP1 1 0.03 2.46 1.08 5.00
15 INT202962 CPP Negative_regulation of Positive_regulation of BAG3 1 0.26 1.34 0.61 5.00
16 INT202971 Binding of BAG3 and CAP1 1 0.04 1.26 0.59 5.00
17 INT202973 Binding of CAP1 and CPP 1 0.05 1.24 0.58 5.00
18 INT202970 Binding of STC2 and CAP1 1 0.00 1.25 0.58 5.00
19 INT182021 Binding of TNF and Il6 2 0.04 0.74 0.53 5.00
20 INT230532 LILRB1 Positive_regulation of Gene_expression of Mmp2 1 0.14 1.04 0.5 5.00
21 INT230533 LILRB1 Positive_regulation of Positive_regulation of Mmp9 1 0.20 1.03 0.5 5.00
22 INT202969 Positive_regulation of SGSM3 Positive_regulation of MCRS1 1 0.02 1.22 0.47 5.00
23 INT202964 SGSM3 Positive_regulation of MCRS1 1 0.03 1.21 0.47 5.00
24 INT222284 Negative_regulation of Casp1 Negative_regulation of Il18 1 0.01 0.79 0.46 5.00
25 INT222283 Negative_regulation of Casp1 Negative_regulation of Il1a 1 0.00 0.78 0.46 5.00
26 INT182100 Positive_regulation of Binding of TNF and Il6 1 0.03 0.66 0.41 5.00
27 INT285327 Binding of Cox8b and Gtf2ird2 1 0.00 0.9 0.29 5.00
28 INT222295 Binding of CPP and Cebpz 1 0.00 0.73 0.05 5.00
29 INT182098 Binding of IL8 and Il2 1 0.00 0 0.04 5.00
30 INT182099 Binding of TNF and Il2 1 0.01 0 0.04 5.00
31 INT182095 Binding of Il2 and Il6 1 0.01 0 0.04 5.00
32 INT302493 Binding of AGRP and IMPACT 1 0.25 0.53 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Brain Death. They are ordered first by their pain relevance and then by number of times they were reported in Brain Death. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT635 Negative_regulation of MAOB 51 0.59 24.5 12.66 100.00
2 INT209390 Negative_regulation of Localization of Ugcg 4 0.20 3.97 1.11 100.00
3 INT209387 Negative_regulation of Ugcg 9 0.25 7.61 0.9 100.00
4 INT154456 Negative_regulation of dds 5 0.37 5.66 0.52 100.00
5 INT175389 Positive_regulation of Ugcg 9 0.32 8.79 1.09 99.98
6 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71 99.90
7 INT227762 Binding of AS3MT 2 0.13 1.19 0.15 99.84
8 INT177910 Gene_expression of AS3MT 7 0.23 6.94 1.08 99.80
9 INT286999 Positive_regulation of Gene_expression of AS3MT 1 0.17 1.14 0 99.44
10 INT37835 Negative_regulation of CPP 61 0.51 31.34 18.57 99.28
11 INT56130 Gene_expression of MC1R 259 0.78 62.7 97.55 99.08
12 INT128003 Negative_regulation of Gene_expression of MC1R 4 0.59 1.56 1.41 99.08
13 INT56860 Gene_expression of Ugcg 17 0.17 12.39 2.03 98.88
14 INT175388 Localization of Ugcg 22 0.37 13.84 2.24 98.68
15 INT66753 Negative_regulation of Positive_regulation of Tnf 45 0.59 35.28 22.33 98.64
16 INT18893 Positive_regulation of CPP 81 0.69 38.03 34.33 98.64
17 INT191252 Localization of DDR1 4 0.45 3.15 0.04 98.36
18 INT13353 Positive_regulation of Tnf 332 0.70 248.75 148.1 98.08
19 INT191253 Negative_regulation of DDR1 13 0.25 10.05 1.05 97.28
20 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 96.72
21 INT154455 Gene_expression of dds 4 0.58 3.84 0.46 94.44
22 INT165495 Negative_regulation of Gene_expression of Itga6 1 0.53 0.99 0.39 93.20
23 INT111981 Gene_expression of Itga6 2 0.70 1.14 0.38 93.20
24 INT202035 Gene_expression of LILRB1 5 0.75 4.78 1.41 93.12
25 INT51460 Negative_regulation of Gene_expression of Sele 8 0.52 10.18 2.89 91.68
26 INT49487 Gene_expression of Sele 65 0.76 68.11 19.41 91.68
27 INT129279 Negative_regulation of D17Mit246 1 0.35 2.72 0.97 89.52
28 INT286998 Negative_regulation of AS3MT 1 0.15 0.78 0.04 89.28
29 INT15470 Regulation of CPP 42 0.48 26.1 18.25 87.76
30 INT63340 Positive_regulation of Gene_expression of ICAM1 109 0.70 90.82 20.61 85.72
31 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 85.20
32 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 81.68
33 INT162253 Gene_expression of BAG3 30 0.59 20.16 7.18 79.64
34 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 78.16
35 INT168479 Binding of BAG3 13 0.36 10.68 4.21 76.72
36 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 76.56
37 INT202978 Gene_expression of STC2 11 0.50 13.46 4.06 76.56
38 INT202977 Binding of STC2 1 0.02 8.53 3.31 76.24
39 INT184895 Gene_expression of MCRS1 46 0.42 56.03 19.44 75.72
40 INT47710 Negative_regulation of GRIN1 71 0.57 25.57 34.24 75.00
41 INT145502 Binding of dds 2 0.39 4.44 0.16 75.00
42 INT22429 Positive_regulation of PDAP1 34 0.61 22.58 2.91 74.36
43 INT94007 Binding of Pphn 4 0.31 0.63 0.31 73.96
44 INT91217 Positive_regulation of BAG3 22 0.48 16.57 6.06 73.24
45 INT202976 Positive_regulation of STC2 1 0.04 9.73 3.78 72.92
46 INT201210 Negative_regulation of ISL1 2 0.02 0.4 0.16 72.40
47 INT193582 Gene_expression of PVR 21 0.58 14 2.39 71.52
48 INT230524 Binding of LILRB1 2 0.35 2.14 0.15 67.48
49 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 65.28
50 INT88005 Binding of MYOD1 6 0.30 2.08 0.42 64.72
51 INT177909 Positive_regulation of AS3MT 2 0.17 1.84 0.09 64.44
52 INT72924 Negative_regulation of MCRS1 27 0.19 33.59 10.29 64.08
53 INT175554 Binding of MCRS1 21 0.23 25.2 8.59 64.08
54 INT18894 Gene_expression of CPP 44 0.77 23.05 23.05 61.20
55 INT90177 Positive_regulation of Gene_expression of CPP 3 0.35 1.94 1.69 61.20
56 INT123970 Negative_regulation of BAG3 11 0.38 5.29 2.6 60.12
57 INT22785 Negative_regulation of PRNP 12 0.57 5.09 1.57 59.92
58 INT12082 Localization of IL6 365 0.81 241.78 105.78 53.96
59 INT11764 Positive_regulation of ENG 78 0.61 27.65 33.69 52.28
60 INT178884 Positive_regulation of dds 1 0.40 1.76 0.18 50.00
61 INT46833 Positive_regulation of SGSM3 56 0.67 24.49 30.31 38.24
62 INT72923 Positive_regulation of MCRS1 72 0.50 99.19 30.36 37.44
63 INT13362 Gene_expression of NFKBIL1 12 0.59 3.79 3.99 36.40
64 INT177630 Regulation of Gene_expression of NFKBIL1 1 0.37 0.92 0.09 36.40
65 INT47909 Binding of CPP 32 0.48 24.9 13.79 32.04
66 INT93309 Positive_regulation of CAP1 17 0.43 11.4 9.13 26.16
67 INT193281 Binding of CAP1 7 0.07 4.57 3.53 18.72
68 INT202984 Negative_regulation of STC2 1 0.02 1.63 0.56 18.24
69 INT189313 Localization of STC2 2 0.29 2.35 0.62 17.36
70 INT103463 Localization of CPP 16 0.66 9.63 4.08 16.80
71 INT159673 Positive_regulation of Localization of CPP 4 0.41 3.43 1.34 16.80
72 INT285324 Negative_regulation of Cox8b 1 0.07 1.59 0.37 14.60
73 INT184890 Regulation of MCRS1 35 0.22 44.35 13.78 13.48
74 INT11047 Positive_regulation of Positive_regulation of IL6 45 0.66 28.7 9.37 11.48
75 INT85233 Localization of SGSM3 11 0.78 10.91 3.41 5.32
76 INT184894 Localization of MCRS1 9 0.47 10.04 3.31 5.32
77 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
78 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
79 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
80 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 5.00
81 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
82 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08 5.00
83 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 5.00
84 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
85 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
86 INT48895 Gene_expression of Il10 333 0.78 221.2 138.52 5.00
87 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87 5.00
88 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
89 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 5.00
90 INT64636 Positive_regulation of Gene_expression of Nos2 242 0.70 147.52 79.53 5.00
91 INT5969 Gene_expression of Il1a 221 0.75 96.31 71.38 5.00
92 INT11807 Gene_expression of Il2 266 0.78 112 64.97 5.00
93 INT11937 Localization of Il6 228 0.81 139.83 64.39 5.00
94 INT48952 Negative_regulation of Nos2 204 0.59 101.73 53.15 5.00
95 INT12345 Gene_expression of Il2 142 0.78 59.17 51.21 5.00
96 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
97 INT170646 Negative_regulation of Fig4 213 0.37 81.29 46.92 5.00
98 INT25610 Positive_regulation of Gene_expression of Il1 136 0.67 104.43 43.86 5.00
99 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 5.00
100 INT68975 Gene_expression of Mmp9 111 0.78 79.57 38.55 5.00
101 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61 5.00
102 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53 5.00
103 INT62827 Positive_regulation of ICAM1 184 0.70 180.95 36.28 5.00
104 INT7675 Gene_expression of ENG 146 0.77 45.35 34.6 5.00
105 INT234 Binding of Alb 151 0.48 52.34 32.97 5.00
106 INT64171 Regulation of CPOX 109 0.36 55.36 32.96 5.00
107 INT9658 Negative_regulation of Gene_expression of Il6 110 0.59 66.29 32.58 5.00
108 INT29503 Gene_expression of Mmp2 95 0.77 56.92 31.68 5.00
109 INT68973 Positive_regulation of Mmp9 89 0.52 58.56 30.04 5.00
110 INT86437 Binding of IL6 154 0.48 121.22 29.3 5.00
111 INT5966 Localization of Il1a 50 0.78 22.91 26.54 5.00
112 INT47075 Positive_regulation of Ptger2 142 0.70 78.55 25.47 5.00
113 INT3589 Positive_regulation of SCN5A 101 0.57 46.01 21.73 5.00
114 INT74682 Positive_regulation of Mmp2 72 0.69 40.46 21.73 5.00
115 INT74286 Regulation of Il10 42 0.44 28.06 19.44 5.00
116 INT10565 Gene_expression of MRXS5 94 0.53 37.35 19.08 5.00
117 INT87861 Gene_expression of Il18 33 0.78 30.44 18.42 5.00
118 INT6782 Gene_expression of SCN5A 156 0.78 33.13 17.88 5.00
119 INT21532 Negative_regulation of Gene_expression of Il2 47 0.59 20.43 16.96 5.00
120 INT10187 Gene_expression of Il2ra 91 0.78 52.67 16.66 5.00
121 INT11685 Regulation of CSF2 99 0.59 58.82 15.9 5.00
122 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 5.00
123 INT170335 Gene_expression of INCENP 176 0.54 91.62 15.31 5.00
124 INT49532 Regulation of Gene_expression of Il6 43 0.61 25.8 14.99 5.00
125 INT116528 Gene_expression of HMOX1 106 0.78 86.13 12.8 5.00
126 INT52905 Gene_expression of Cd4 84 0.78 45.68 12.75 5.00
127 INT32595 Positive_regulation of Gene_expression of Il2 30 0.70 6.55 12.56 5.00
128 INT48335 Negative_regulation of NOSTRIN 38 0.56 16.22 12.05 5.00
129 INT10654 Negative_regulation of SGSM3 31 0.57 12.24 11.7 5.00
130 INT73959 Positive_regulation of NOSTRIN 49 0.61 31.1 11.27 5.00
131 INT74681 Positive_regulation of Gene_expression of Mmp2 23 0.55 15.58 10.74 5.00
132 INT74272 Localization of CPOX 39 0.63 25.12 10.53 5.00
133 INT49129 Positive_regulation of GFAP 35 0.69 28.78 10.38 5.00
134 INT12344 Negative_regulation of Gene_expression of Il2 28 0.59 15.53 10.23 5.00
135 INT11859 Positive_regulation of Tbxa2r 44 0.61 22.62 9.61 5.00
136 INT45914 Gene_expression of Apcs 22 0.65 24.25 8.48 5.00
137 INT24141 Negative_regulation of Apcs 24 0.59 16.82 8.29 5.00
138 INT34009 Binding of Tbxa2r 33 0.36 17.98 8.01 5.00
139 INT50040 Localization of Il4 15 0.67 8.26 7.69 5.00
140 INT81586 Negative_regulation of Casp1 11 0.57 6.55 6.45 5.00
141 INT50070 Negative_regulation of NFKBIL1 14 0.48 3.76 5.92 5.00
142 INT71220 Positive_regulation of Casp1 15 0.38 10.23 5.84 5.00
143 INT12066 Localization of Il2 16 0.75 3.06 5.7 5.00
144 INT81796 Binding of AGRP 62 0.36 37.19 5.3 5.00
145 INT15652 Positive_regulation of ENO2 37 0.68 33.39 5.02 5.00
146 INT26583 Positive_regulation of Cd4 40 0.54 21.96 4.83 5.00
147 INT162254 Regulation of BAG3 28 0.41 18.12 4.75 5.00
148 INT24889 Negative_regulation of CABIN1 36 0.48 16.76 4.73 5.00
149 INT69966 Positive_regulation of Negative_regulation of CPOX 11 0.45 6.18 4.64 5.00
150 INT75530 Regulation of SGSM3 11 0.60 7.22 4.48 5.00
151 INT38859 Gene_expression of SGSM3 14 0.75 12.98 4.09 5.00
152 INT17548 Negative_regulation of Serpine1 30 0.57 24.69 3.93 5.00
153 INT61680 Positive_regulation of PVR 23 0.60 23.27 3.86 5.00
154 INT60933 Positive_regulation of Apcs 16 0.67 11.69 3.68 5.00
155 INT64030 Gene_expression of Cd8a 15 0.56 4.8 3.63 5.00
156 INT67468 Regulation of SCN5A 27 0.44 4.4 3.47 5.00
157 INT202983 Regulation of STC2 1 0.03 11.98 3.33 5.00
158 INT61087 Positive_regulation of Gene_expression of Il2ra 12 0.35 9.1 3.25 5.00
159 INT17749 Positive_regulation of Gene_expression of MRXS5 15 0.23 8.02 3.15 5.00
160 INT17750 Localization of MRXS5 15 0.56 6.65 3.1 5.00
161 INT305617 Positive_regulation of Gene_expression of MCRS1 1 0.05 7.16 2.91 5.00
162 INT10189 Negative_regulation of Gene_expression of Il2ra 8 0.32 8.05 2.91 5.00
163 INT36489 Regulation of Apcs 12 0.58 10.6 2.78 5.00
164 INT222289 Localization of Il18 4 0.30 3.24 2.58 5.00
165 INT3308 Localization of PTGER1 9 0.73 5.32 2.55 5.00
166 INT188756 Positive_regulation of AGRP 43 0.60 23.67 2.51 5.00
167 INT76341 Negative_regulation of Positive_regulation of Ptger2 12 0.25 6.63 2.42 5.00
168 INT5968 Positive_regulation of Localization of Il1a 4 0.65 1.36 2.42 5.00
169 INT3315 Negative_regulation of Positive_regulation of INS 31 0.57 14.73 2.27 5.00
170 INT11580 Binding of Cebpz 8 0.40 7.16 2.19 5.00
171 INT83468 Gene_expression of ELK3 22 0.66 2.91 2.03 5.00
172 INT98888 Negative_regulation of Gene_expression of Il18 3 0.43 1.72 2.02 5.00
173 INT59302 Positive_regulation of POR 19 0.49 15.18 1.95 5.00
174 INT135961 Positive_regulation of Hc 8 0.67 3.67 1.87 5.00
175 INT15916 Positive_regulation of Ptgis 11 0.39 6.6 1.74 5.00
176 INT94892 Regulation of NOSTRIN 7 0.31 2.99 1.72 5.00
177 INT3818 Regulation of Apc 13 0.39 12.52 1.68 5.00
178 INT29557 Localization of MIA3 23 0.57 6.78 1.6 5.00
179 INT289202 Gene_expression of TRIO 5 0.23 1.21 1.49 5.00
180 INT171975 Negative_regulation of Gene_expression of INCENP 8 0.05 5.24 1.35 5.00
181 INT52589 Positive_regulation of Gene_expression of SCN5A 14 0.49 3.84 1.33 5.00
182 INT127283 Regulation of Gene_expression of HMOX1 14 0.61 11.8 1.28 5.00
183 INT305616 Negative_regulation of Gene_expression of MCRS1 1 0.04 3.56 1.23 5.00
184 INT74625 Gene_expression of IL36B 4 0.37 2.04 1.19 5.00
185 INT18922 Gene_expression of Klk1c7 5 0.18 1.44 1.18 5.00
186 INT40057 Binding of MRXS5 4 0.31 1.75 1.17 5.00
187 INT176317 Transcription of CAP1 3 0.16 1.8 1.15 5.00
188 INT34141 Positive_regulation of IMPA1 8 0.50 2.38 1.12 5.00
189 INT28929 Negative_regulation of PVR 22 0.57 16.64 1.07 5.00
190 INT202981 Positive_regulation of Binding of MCRS1 3 0.18 4.05 1.02 5.00
191 INT305620 Regulation of Positive_regulation of MCRS1 1 0.17 2.48 0.99 5.00
192 INT230779 Negative_regulation of Positive_regulation of MCRS1 2 0.04 3.78 0.92 5.00
193 INT186181 Gene_expression of ZC3H12A 4 0.08 2.91 0.85 5.00
194 INT13329 Localization of NFKBIL1 3 0.69 0 0.82 5.00
195 INT202979 Negative_regulation of Gene_expression of BAG3 1 0.27 1.75 0.82 5.00
196 INT162256 Positive_regulation of Binding of CPP 2 0.60 1.94 0.81 5.00
197 INT230516 Negative_regulation of Localization of Il2 5 0.15 2.64 0.79 5.00
198 INT182091 Negative_regulation of Binding of MRXS5 1 0.02 0.61 0.78 5.00
199 INT123463 Gene_expression of ATP5G3 5 0.37 2.25 0.75 5.00
200 INT276424 Negative_regulation of IMPACT 4 0.32 2.6 0.72 5.00
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