D:Brain Disease

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pChart

Disease Term
Synonyms Brain Diseases, BRAIN DISORDER, Brain Disorders, BRAIN PATHOLOGY, CENTRAL NERVOUS SYSTEM DISORDERS INTRACRANIAL, Central Nervous System Intracranial Disorders, Cns Disorder Intracranial, Cns Disorders Intracranial, Disease Of The Brain, Disorder Of The Brain, Disorders Of The Brain
Documents 555
Hot Single Events 200
Hot Interactions 11

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Brain Disease. They are ordered first by their relevance to Brain Disease and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT302364 Binding of Arx and Reln 1 0.32 1.25 0 99.98
2 INT302370 Binding of Arx and Dcx 1 0.35 1.25 0 99.98
3 INT302373 Binding of Arx and Tuba1a 1 0.30 1.26 0 99.98
4 INT302368 Binding of Arx and Pafah1b1 1 0.27 1.25 0 99.98
5 INT261391 Binding of Nsdhl and P4hb 1 0.02 1.3 0.1 97.72
6 INT261380 Nsdhl Negative_regulation of P4hb 1 0.02 1.36 0.11 94.72
7 INT111134 Binding of Krit1 and Rap1a 1 0.07 0.81 0.1 93.64
8 INT233397 Binding of ABCA4 and COL2A1 1 0.38 3.59 0.03 92.56
9 INT10881 SGCG Negative_regulation of Avp 1 0.21 0.09 0.17 91.00
10 INT261390 Binding of Nsdhl and Bdnf 1 0.05 1.33 0.12 82.80
11 INT243214 Myst2 Negative_regulation of Gene_expression of Ptgs2 1 0.01 1.4 0.28 81.76
12 INT184874 Drd1a Regulation of Gene_expression of Drd2 1 0.13 0.97 0.51 79.60
13 INT202965 Binding of STC2 and BAG3 1 0.02 7.86 2.96 75.08
14 INT140386 Spp1 Positive_regulation of NFKB1 1 0.21 1.29 0.3 75.00
15 INT140385 Spp1 Negative_regulation of FOXO3 1 0.04 1.29 0.3 75.00
16 INT261398 Nsdhl Positive_regulation of Binding of Nsdhl and Med1 1 0.01 2.14 0.09 66.80
17 INT261393 Binding of Nsdhl and Med1 1 0.02 1 0.04 66.80
18 INT341218 Binding of Eif4e and Eif4ebp1 1 0.19 2.65 1.23 66.68
19 INT253637 TNF Regulation of Transcription of HIVEP1 1 0.07 1.72 0.26 66.48
20 INT261396 Nsdhl Positive_regulation of Transcription of Esr1 1 0.02 2.1 0.09 64.56
21 INT296293 Prkaca Regulation of Positive_regulation of Creb1 1 0.16 0.62 0.55 64.48
22 INT296291 Prkaca Regulation of Localization of Calm3 1 0.09 0.62 0.55 64.48
23 INT296273 Prkaca Regulation of Localization of Camk4 1 0.16 0.62 0.55 64.48
24 INT261371 Nsdhl Negative_regulation of Positive_regulation of Bdnf 1 0.06 1.18 0.09 64.40
25 INT296302 Camk4 Regulation of Localization of Calm3 1 0.15 0.31 0.28 64.16
26 INT296287 Camk4 Regulation of Positive_regulation of Creb1 1 0.27 0.31 0.27 64.16
27 INT296284 Calm3 Regulation of Positive_regulation of Creb1 1 0.09 0.31 0.28 63.88
28 INT296281 Calm3 Regulation of Localization of Camk4 1 0.13 0.31 0.28 63.88
29 INT210982 Binding of Cnr1 and Cfp 2 0.22 1.27 1.2 59.36
30 INT341220 Eif4e Positive_regulation of Eif4ebp1 1 0.20 0.42 0.06 53.72
31 INT296277 Binding of Car2 and Kcnip3 5 0.18 1.09 2.06 51.48
32 INT274080 Binding of ARHGAP4 and Map3k5 1 0.41 1.92 0.2 50.88
33 INT201378 Bdnf Regulation of Gene_expression of Ltp 1 0.00 0.21 0.07 50.00
34 INT296276 Binding of Preb and Kcnip3 1 0.02 0.06 0.16 45.96
35 INT296294 Binding of Kcnip3 and Dre 1 0.13 0.06 0.16 45.96
36 INT316052 Notch1 Regulation of Binding of Cd8a 1 0.01 0.86 0.15 45.12
37 INT316053 Notch1 Regulation of Binding of Cd4 1 0.02 0.86 0.15 45.12
38 INT316050 Binding of Notch1 and Regulation of Binding of Cd8a 1 0.01 0.86 0.15 45.12
39 INT316051 Binding of Notch1 and Regulation of Binding of Cd4 1 0.02 0.86 0.15 45.12
40 INT316059 Ps Regulation of Binding of Cd4 1 0.06 0.86 0.13 44.48
41 INT316058 Ps Regulation of Binding of Cd8a 1 0.02 0.86 0.13 44.48
42 INT199667 Cep290 Regulation of Atf4 1 0.04 1.96 0.09 43.00
43 INT199666 Cntln Regulation of Atf4 1 0.00 1.95 0.09 42.28
44 INT315399 Adcyap1 Positive_regulation of Binding of IFNA1 1 0.02 0 0.06 38.48
45 INT261376 Nsdhl Positive_regulation of Gene_expression of Nrgn 1 0.06 0.86 0.08 29.36
46 INT313778 Gene_expression of Crhq1 Negative_regulation of Localization of Crh 1 0.05 0.66 0.71 28.60
47 INT335743 Binding of PDB1 and Salpa1 1 0.01 1.66 0.09 28.20
48 INT335742 Binding of PDB1 and Dpyd 1 0.02 1.75 0.09 28.20
49 INT326585 Binding of GYPA and SLC6A3 1 0.13 0.86 2.64 28.08
50 INT228333 Binding of IFNA1 and IRF9 2 0.04 0.53 0.09 26.08
51 INT288350 IFNA1 Positive_regulation of Localization of Il6 1 0.01 1.49 0.46 5.24
52 INT179502 Binding of Cd14 and Tlr4 29 0.39 13.77 5.73 5.00
53 INT296275 Binding of Dlg4 and Kcnip3 1 0.39 3.58 5.6 5.00
54 INT181455 Binding of Ccr5 and Ccl5 11 0.39 12.13 3.66 5.00
55 INT189488 Binding of Ccr1 and Ccl5 8 0.40 9.26 3.27 5.00
56 INT202959 Binding of BAG3 and MCRS1 1 0.11 7.46 3.14 5.00
57 INT170367 Binding of Grin1 and Grin2a 5 0.23 1.72 2.79 5.00
58 INT202974 Binding of BAG3 and CPP 1 0.25 6.22 2.73 5.00
59 INT189490 Binding of Ccr3 and Ccl5 1 0.33 8.54 2.6 5.00
60 INT202963 Binding of STC2 and CPP 1 0.02 5.16 2.04 5.00
61 INT115048 Kcnip3 Regulation of Gene_expression of Pdyn 2 0.27 0.71 1.78 5.00
62 INT296280 Binding of Car2 and Dlg4 1 0.19 0.45 1.71 5.00
63 INT172206 Binding of Slc6a3 and ADHD1 2 0.03 2.76 1.61 5.00
64 INT202958 Binding of STC2 and MCRS1 1 0.01 3.48 1.44 5.00
65 INT281479 Drd2 Positive_regulation of Penk 1 0.23 0.4 1.3 5.00
66 INT251142 Binding of Dlg4 and Grin2a 3 0.30 0.5 1.24 5.00
67 INT261410 Slc7a2 Positive_regulation of Ltp 1 0.06 0.08 1.21 5.00
68 INT330379 Gene_expression of IL10 Negative_regulation of Positive_regulation of MAPK14 1 0.00 1.95 1.18 5.00
69 INT202960 Binding of MCRS1 and CPP 1 0.14 2.49 1.13 5.00
70 INT202968 Binding of MCRS1 and CAP1 1 0.03 2.46 1.08 5.00
71 INT218840 Cysltr1 Positive_regulation of Ltp 2 0.02 1.04 1.06 5.00
72 INT238091 Binding of GRIP1 and Mmp24 1 0.00 0 0.98 5.00
73 INT238092 Binding of SHBG and Mmp24 1 0.04 0 0.98 5.00
74 INT36683 Gh1 Regulation of Gnrhr 3 0.08 1.25 0.95 5.00
75 INT296283 Kcnip3 Regulation of Positive_regulation of Cysltr1 1 0.01 0.85 0.94 5.00
76 INT296278 Insrr Positive_regulation of Cysltr1 1 0.00 0.99 0.92 5.00
77 INT281482 Drd2 Positive_regulation of Drd2 Positive_regulation of Penk 1 0.21 0.27 0.87 5.00
78 INT197470 Binding of Sostdc1 and Hbtq 1 0.00 0.87 0.87 5.00
79 INT228255 Binding of Akt1 and Pten 2 0.43 1.78 0.8 5.00
80 INT296299 Positive_regulation of Cysltr1 Positive_regulation of Positive_regulation of Rbm39 1 0.00 0.59 0.79 5.00
81 INT296279 Positive_regulation of Rbm39 Positive_regulation of Positive_regulation of Car2 1 0.01 0.58 0.78 5.00
82 INT261413 Positive_regulation of GRIN1 Positive_regulation of Positive_regulation of Creb1 1 0.00 0.81 0.77 5.00
83 INT296297 Positive_regulation of Cysltr1 Positive_regulation of Positive_regulation of Car2 1 0.01 0.59 0.77 5.00
84 INT224280 Bdnf Positive_regulation of Creb1 3 0.30 0.62 0.77 5.00
85 INT210984 Cfp Positive_regulation of Positive_regulation of Dio1 1 0.07 0.81 0.75 5.00
86 INT210979 Grm5 Positive_regulation of Cysltr1 1 0.00 0.76 0.75 5.00
87 INT210980 Cysltr1 Positive_regulation of Positive_regulation of Dio1 1 0.00 0.81 0.75 5.00
88 INT202967 MCRS1 Negative_regulation of CPP 2 0.14 2.2 0.73 5.00
89 INT296285 Binding of Car1 and Grin2b 1 0.14 0.32 0.72 5.00
90 INT296292 Binding of Car1 and Grin2a 1 0.14 0.32 0.72 5.00
91 INT296289 Grin2a Regulation of Negative_regulation of Kcnip3 1 0.30 0.3 0.72 5.00
92 INT296290 Binding of Car1 and Grin1 1 0.11 0.32 0.72 5.00
93 INT296282 Grin2b Regulation of Negative_regulation of Kcnip3 1 0.30 0.3 0.72 5.00
94 INT296295 Binding of Grin1 and Grin2b 1 0.16 0.31 0.71 5.00
95 INT296298 Grin2b Regulation of Negative_regulation of Hmmr 1 0.03 0.29 0.71 5.00
96 INT296288 Grin2a Regulation of Negative_regulation of Hmmr 1 0.03 0.29 0.71 5.00
97 INT142994 Binding of UPF1 and FCMTE1 1 0.00 0.91 0.7 5.00
98 INT261378 Nsdhl Negative_regulation of Gene_expression of Flvcr2 1 0.01 0.34 0.7 5.00
99 INT187522 ATIC Negative_regulation of Gene_expression of Nos2 1 0.02 1.46 0.7 5.00
100 INT210981 Calb1 Positive_regulation of Cysltr1 1 0.00 0.81 0.69 5.00
101 INT209593 Negative_regulation of Adcy1 Negative_regulation of Positive_regulation of Ltp 1 0.10 0 0.69 5.00
102 INT210985 Positive_regulation of Calb1 Positive_regulation of Cysltr1 1 0.00 0.81 0.69 5.00
103 INT210983 Calb1 Positive_regulation of Cnr1 1 0.01 0.81 0.68 5.00
104 INT231533 IL4 Positive_regulation of LRP5 1 0.00 0.87 0.67 5.00
105 INT326586 SLC18A2 Negative_regulation of DDC 1 0.28 0.91 0.66 5.00
106 INT231534 Binding of JAK1 and SOAT1 1 0.01 0.6 0.64 5.00
107 INT302441 Binding of GRIN1 and Grin2b 1 0.10 1.27 0.63 5.00
108 INT333544 CTSB Regulation of Protein_catabolism of APP 1 0.01 0.53 0.62 5.00
109 INT333543 CTSB Regulation of APP 1 0.01 0.53 0.62 5.00
110 INT202962 CPP Negative_regulation of Positive_regulation of BAG3 1 0.26 1.34 0.61 5.00
111 INT202971 Binding of BAG3 and CAP1 1 0.04 1.26 0.59 5.00
112 INT261372 Gsk3b Regulation of Gene_expression of Ifi205 1 0.00 0.24 0.58 5.00
113 INT202973 Binding of CAP1 and CPP 1 0.05 1.24 0.58 5.00
114 INT202970 Binding of STC2 and CAP1 1 0.00 1.25 0.58 5.00
115 INT202972 Positive_regulation of MCRS1 Negative_regulation of CPP 1 0.16 1.64 0.57 5.00
116 INT202961 MCRS1 Negative_regulation of STC2 1 0.00 1.63 0.57 5.00
117 INT223556 Churc1 Regulation of Cnr2 1 0.00 0.8 0.54 5.00
118 INT209591 Car2 Positive_regulation of Positive_regulation of Ltp 1 0.05 0 0.54 5.00
119 INT209592 Car2 Positive_regulation of Localization of Ltp 1 0.05 0 0.54 5.00
120 INT184878 Binding of Lmo1 and ADHD1 2 0.04 2.33 0.53 5.00
121 INT179503 Cd14 Regulation of Positive_regulation of Tlr4 1 0.38 0.58 0.52 5.00
122 INT223558 Dpcr1 Regulation of Cms1 1 0.00 0.79 0.51 5.00
123 INT202957 CPP Negative_regulation of MCRS1 1 0.14 1.53 0.51 5.00
124 INT179507 Tlr4 Positive_regulation of Tlr2 2 0.17 1.07 0.49 5.00
125 INT36684 Gh1 Regulation of Prl 2 0.18 1.25 0.48 5.00
126 INT202969 Positive_regulation of SGSM3 Positive_regulation of MCRS1 1 0.02 1.22 0.47 5.00
127 INT202964 SGSM3 Positive_regulation of MCRS1 1 0.03 1.21 0.47 5.00
128 INT312813 Binding of F2rl1 and Tpsab1 1 0.01 0.26 0.46 5.00
129 INT317427 IFN1@ Positive_regulation of ISYNA1 1 0.12 0.49 0.45 5.00
130 INT184877 Negative_regulation of Binding of Slc6a3 and ADHD1 1 0.01 0.69 0.45 5.00
131 INT319554 Sgk1 Regulation of Cdkn1a 1 0.26 0.09 0.45 5.00
132 INT341226 Gopc Regulation of Shc3 1 0.00 0.68 0.45 5.00
133 INT341211 Gopc Regulation of Shc1 1 0.02 0.68 0.45 5.00
134 INT312814 TNF Positive_regulation of Spg21 1 0.00 0.6 0.45 5.00
135 INT302369 Binding of Arx and Dlx1 1 0.34 0 0.43 5.00
136 INT261374 Nsdhl Regulation of Esr2 1 0.05 0.76 0.41 5.00
137 INT316063 Ps Positive_regulation of IL8 1 0.09 1.33 0.41 5.00
138 INT261370 Nsdhl Regulation of Esr1 1 0.01 0.75 0.41 5.00
139 INT316065 Eif1 Positive_regulation of IL8 1 0.01 1.34 0.41 5.00
140 INT333512 Binding of GPI and MCF2L 1 0.09 0.75 0.41 5.00
141 INT187487 Cebpg Positive_regulation of Gene_expression of Nos2 1 0.03 0.38 0.4 5.00
142 INT296296 Binding of Grin2b and Kcnip3 1 0.24 0 0.4 5.00
143 INT296300 Binding of Grin1 and Kcnip3 1 0.18 0 0.4 5.00
144 INT296301 Binding of Grin2a and Kcnip3 1 0.27 0 0.4 5.00
145 INT187519 ATIC Negative_regulation of Gene_expression of Ros1 1 0.00 1.48 0.39 5.00
146 INT187521 ATIC Positive_regulation of Prkag1 1 0.01 1.07 0.37 5.00
147 INT189493 Tnf Positive_regulation of Localization of Darc 1 0.00 0.53 0.37 5.00
148 INT189491 Icam1 Positive_regulation of Transcription of Ccl5 1 0.19 0.64 0.36 5.00
149 INT231535 Binding of JAK2 and SOAT1 1 0.01 0.3 0.35 5.00
150 INT302371 Dlx1 Regulation of Gene_expression of Arx 1 0.28 0 0.35 5.00
151 INT187488 Positive_regulation of Ros1 Positive_regulation of Gene_expression of Nos2 1 0.01 0.88 0.35 5.00
152 INT189492 Ifng Positive_regulation of Localization of Darc 1 0.00 0.53 0.34 5.00
153 INT189489 Il1b Positive_regulation of Localization of Darc 1 0.00 0.53 0.34 5.00
154 INT315400 IFNA1 Positive_regulation of Phosphorylation of Stat1 1 0.02 0.4 0.33 5.00
155 INT326587 GYPA Regulation of DDC 1 0.08 0.83 0.33 5.00
156 INT341215 Binding of Eif4e and Eif4g3 1 0.10 0.41 0.33 5.00
157 INT189494 Negative_regulation of Ccr5 Negative_regulation of Gene_expression of Hand1 1 0.16 0.66 0.32 5.00
158 INT330377 Positive_regulation of Binding of TLR2 and TLR9 1 0.09 2.79 0.32 5.00
159 INT330381 Binding of TLR2 and TLR9 1 0.07 2.77 0.32 5.00
160 INT315385 Adcyap1 Positive_regulation of Phosphorylation of Bad 1 0.05 0.44 0.32 5.00
161 INT330389 Positive_regulation of Binding of TLR2 and TLR8 1 0.08 2.78 0.32 5.00
162 INT315387 Adcyap1 Positive_regulation of Phosphorylation of Gopc 1 0.03 0.44 0.32 5.00
163 INT341214 Tas2r130 Positive_regulation of Phosphorylation of Eif4ebp1 1 0.00 0.68 0.31 5.00
164 INT330383 Binding of TLR2 and TLR3 1 0.07 2.77 0.31 5.00
165 INT330378 Positive_regulation of Binding of TLR2 and TLR3 1 0.10 2.78 0.31 5.00
166 INT330387 Binding of TLR2 and TLR8 1 0.06 2.77 0.31 5.00
167 INT187523 IRF6 Positive_regulation of Gene_expression of Cpox 1 0.00 1.38 0.31 5.00
168 INT315394 IFNA1 Positive_regulation of Gene_expression of Socs1 1 0.01 0.41 0.31 5.00
169 INT315392 IFNA1 Positive_regulation of Stat1 1 0.02 0.4 0.3 5.00
170 INT315398 IFNA1 Positive_regulation of Socs1 1 0.01 0.41 0.3 5.00
171 INT215683 P2ry2 Positive_regulation of Gene_expression of Il6 1 0.02 0.76 0.29 5.00
172 INT293900 TYRP1 Regulation of IGKC 1 0.01 0.11 0.27 5.00
173 INT288497 Binding of Tlr7 and Tlr9 1 0.21 0.97 0.27 5.00
174 INT302439 Binding of ras and Rtn4r 1 0.04 0.08 0.27 5.00
175 INT315393 Bdnf Positive_regulation of Gene_expression of IFNA1 1 0.01 0.37 0.26 5.00
176 INT302438 Binding of Raf1 and Rtn4r 1 0.04 0.08 0.26 5.00
177 INT261375 Binding of Nsdhl and Pparg 1 0.05 1.03 0.25 5.00
178 INT187518 Positive_regulation of ATIC Positive_regulation of Prkag1 1 0.01 0.99 0.25 5.00
179 INT261394 Nsdhl Negative_regulation of nt 1 0.01 1.69 0.24 5.00
180 INT319556 Positive_regulation of Jun Negative_regulation of Positive_regulation of gr 1 0.05 0.17 0.24 5.00
181 INT319557 Jun Negative_regulation of gr 1 0.05 0.05 0.23 5.00
182 INT261389 Nsdhl Positive_regulation of Esr2 1 0.06 1.04 0.23 5.00
183 INT328228 Binding of Cpox and Hmox1 1 0.03 0.83 0.23 5.00
184 INT283948 SALL1 Positive_regulation of Positive_regulation of Ptgfrn 1 0.00 0.21 0.22 5.00
185 INT302367 Dlx2 Regulation of Gene_expression of Arx 1 0.59 0.23 0.22 5.00
186 INT319555 gr Positive_regulation of Positive_regulation of Hpse 1 0.09 0.11 0.22 5.00
187 INT326583 GYPA Negative_regulation of Binding of GYPA and SLC6A3 1 0.03 0.22 0.22 5.00
188 INT187485 Trib3 Positive_regulation of Prkag1 1 0.00 0.97 0.22 5.00
189 INT187486 Binding of Prkag1 and Stk11 1 0.01 0.95 0.22 5.00
190 INT188746 Binding of CSF2 and HIVEP1 1 0.04 3.99 0.21 5.00
191 INT316054 Eif1 Positive_regulation of Il6 1 0.00 0.78 0.21 5.00
192 INT330382 IFNA1 Positive_regulation of Gene_expression of IL10 1 0.06 0.83 0.21 5.00
193 INT316062 Ps Positive_regulation of Il6 1 0.04 0.77 0.21 5.00
194 INT315384 Adcyap1 Negative_regulation of Positive_regulation of Casp3 1 0.02 0.53 0.2 5.00
195 INT312815 IL1B Positive_regulation of Localization of Il6 1 0.00 0.33 0.2 5.00
196 INT315386 Adcyap1 Positive_regulation of Bad 1 0.03 0.52 0.2 5.00
197 INT316064 Binding of RBPJ and Csl 1 0.16 0.33 0.2 5.00
198 INT330371 Binding of TLR3 and Ifx 1 0.17 1.12 0.2 5.00
199 INT333510 Positive_regulation of STON1 Positive_regulation of GPI 1 0.10 0.38 0.19 5.00
200 INT184868 Binding of Slc6a3 and Lmo1 1 0.02 0.72 0.19 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Brain Disease. They are ordered first by their pain relevance and then by number of times they were reported in Brain Disease. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT342468 Positive_regulation of MAFD1 2 0.03 1.48 0.04 100.00
2 INT116996 Regulation of Pgp 9 0.51 7.51 8.01 100.00
3 INT546 Binding of ALB 311 0.48 85.98 60.14 100.00
4 INT225965 Localization of Aqp4 26 0.81 18.85 3.75 99.92
5 INT206031 Regulation of Adc 7 0.33 6.85 1.48 99.92
6 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 99.78
7 INT24225 Gene_expression of Alms1 93 0.62 52.75 16.93 99.76
8 INT62960 Gene_expression of P2rx2 149 0.77 58.31 59.16 99.74
9 INT3622 Regulation of CTSB 34 0.58 16.08 8.76 99.72
10 INT162254 Regulation of BAG3 28 0.41 18.12 4.75 99.66
11 INT93120 Localization of Gfap 21 0.78 8.42 3.7 99.60
12 INT69743 Gene_expression of Hmox2 36 0.78 20.77 14.26 99.56
13 INT76405 Positive_regulation of Hmox2 21 0.43 12.77 8.99 99.56
14 INT262487 Positive_regulation of Gene_expression of Aqp9 6 0.32 5.29 0.24 99.52
15 INT202983 Regulation of STC2 1 0.03 11.98 3.33 99.50
16 INT233399 Binding of ABCA4 9 0.46 9.49 0.07 99.42
17 INT84732 Positive_regulation of Hand2 81 0.69 62.07 22 99.38
18 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 99.36
19 INT228298 Gene_expression of INVS 10 0.65 6.44 0.43 99.36
20 INT37889 Gene_expression of P2ry2 75 0.65 26.01 23.8 99.32
21 INT49439 Gene_expression of Cpox 508 0.73 326.97 130.17 99.24
22 INT67039 Positive_regulation of Cpox 144 0.65 98.4 33.77 99.24
23 INT243533 Positive_regulation of SOX10 1 0.35 3.93 0.92 99.16
24 INT341172 Regulation of Eif4ebp1 1 0.20 4.42 0.74 99.16
25 INT130837 Gene_expression of Aqp4 205 0.78 151.23 29.63 99.12
26 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 99.04
27 INT109010 Negative_regulation of Ifnb1 1 0.12 2.47 1.56 98.92
28 INT163486 Negative_regulation of Gene_expression of Slco1c1 2 0.20 0.82 1.24 98.88
29 INT89084 Gene_expression of Slco1c1 15 0.51 4.92 6.02 98.88
30 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 98.88
31 INT55583 Localization of IFNA1 135 0.78 85.07 24.13 98.88
32 INT94464 Negative_regulation of Hand1 44 0.41 31.5 12.39 98.88
33 INT156132 Gene_expression of Aqp9 26 0.49 14.33 3.48 98.68
34 INT114 Binding of Oprl1 139 0.48 23 103.35 98.64
35 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 98.64
36 INT24326 Gene_expression of Ngf 346 0.78 218.67 184.71 98.48
37 INT27954 Positive_regulation of Gene_expression of Ngf 87 0.70 57.91 51.96 98.48
38 INT3275 Negative_regulation of Slco1c1 28 0.37 10.93 5.15 98.24
39 INT190480 Positive_regulation of Localization of Ros1 11 0.34 8.29 1.81 98.16
40 INT18012 Gene_expression of EPO 169 0.78 108.36 13.75 98.12
41 INT50730 Positive_regulation of can 2 0.30 5.37 0.19 98.12
42 INT261366 Binding of P4hb 1 0.04 1.3 0.1 97.64
43 INT139872 Regulation of Notch1 14 0.45 7.69 2.82 97.52
44 INT335724 Positive_regulation of Localization of Tardbp 3 0.47 4.9 0.25 97.12
45 INT194462 Localization of Ppara 94 0.78 68.33 12.09 97.12
46 INT197167 Positive_regulation of Localization of Ppara 18 0.67 9.51 1.21 97.12
47 INT149441 Positive_regulation of MCF2L 5 0.61 3.96 1.82 97.06
48 INT6852 Localization of TNF 883 0.81 705.95 270.84 96.84
49 INT5502 Positive_regulation of Gene_expression of Crh 69 0.70 43.06 42.23 96.80
50 INT55142 Positive_regulation of P4hb 3 0.36 1.38 0.28 96.70
51 INT16260 Gene_expression of Bdnf 671 0.78 283.44 339.1 96.64
52 INT100821 Localization of Ros1 59 0.60 45.26 11.92 96.36
53 INT145426 Positive_regulation of Ros1 185 0.56 106.76 27.21 96.36
54 INT5610 Positive_regulation of Insr 140 0.69 37.26 86.24 96.32
55 INT438 Gene_expression of Crh 376 0.78 159.11 169.17 96.24
56 INT20131 Negative_regulation of Mthfs 18 0.57 7.93 10.54 96.24
57 INT78704 Binding of CCL11 10 0.37 11.38 1.44 96.00
58 INT145948 Binding of CCL24 2 0.33 2.1 1.17 96.00
59 INT11439 Positive_regulation of Csf2 105 0.69 62.63 37.77 95.88
60 INT5207 Negative_regulation of Alms1 70 0.41 41.56 13.68 95.80
61 INT243536 Positive_regulation of EARS2 1 0.11 1.42 0.52 95.64
62 INT292763 Localization of Tardbp 6 0.80 12.51 0.91 95.36
63 INT95427 Positive_regulation of Mmp3 39 0.70 15.28 13.36 95.28
64 INT172689 Localization of Mmp3 15 0.68 5.52 3.32 95.28
65 INT16455 Gene_expression of Drd2 116 0.78 22.71 38.47 94.80
66 INT57039 Positive_regulation of Gene_expression of Drd2 16 0.50 1.98 9.48 94.80
67 INT237045 Positive_regulation of Vcp 7 0.62 6.96 0.12 94.76
68 INT29762 Negative_regulation of P4hb 4 0.21 1.41 0.86 94.72
69 INT135373 Regulation of Gsk3b 35 0.62 18.11 3.53 94.64
70 INT36177 Binding of Alms1 70 0.31 35.47 13.81 94.52
71 INT174987 Binding of AIRN 12 0.32 6.79 1.21 94.24
72 INT96693 Binding of COL2A1 45 0.46 37.11 2.61 94.00
73 INT137052 Positive_regulation of PYCARD 30 0.43 4.72 6.17 93.92
74 INT69821 Negative_regulation of Hrh3 4 0.43 3.59 1.15 93.92
75 INT335733 Positive_regulation of Tardbp 8 0.69 28.41 0.41 93.88
76 INT84546 Positive_regulation of Ppara 481 0.70 334.21 83.45 93.76
77 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 93.76
78 INT176317 Transcription of CAP1 3 0.16 1.8 1.15 93.68
79 INT135316 Gene_expression of Hrh3 9 0.74 5.66 3.14 93.52
80 INT273295 Negative_regulation of Gene_expression of Hrh3 1 0.41 1.05 0.03 93.52
81 INT190585 Gene_expression of Eif4ebp2 2 0.54 1.06 0.15 93.36
82 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34 93.20
83 INT341165 Phosphorylation of Eif4ebp2 1 0.02 1.24 0.17 92.68
84 INT36212 Positive_regulation of Csad 11 0.61 12.31 9.94 92.64
85 INT112986 Positive_regulation of S100b 19 0.70 17.61 6.86 92.64
86 INT20499 Positive_regulation of EPHA8 1 0.41 0.54 0.27 92.64
87 INT316 Regulation of Cebpz 105 0.00 27.21 35.41 92.56
88 INT21952 Gene_expression of GDNF 42 0.78 20.32 9.62 92.44
89 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 92.44
90 INT181356 Positive_regulation of Gene_expression of Ccr5 11 0.66 8.3 2.24 92.32
91 INT143258 Positive_regulation of Gene_expression of Ccr3 4 0.49 3.16 1.27 92.32
92 INT39229 Regulation of Alox5 6 0.57 3.2 1.72 91.84
93 INT291679 Regulation of Transcription of Alox5 1 0.25 0.94 0.28 91.84
94 INT167679 Gene_expression of Ccr5 74 0.75 59.03 18.16 91.84
95 INT89294 Gene_expression of Ccr3 53 0.68 43.9 12.62 91.84
96 INT94029 Positive_regulation of Grin2b 58 0.70 24.2 42.52 91.68
97 INT1898 Regulation of Crh 220 0.62 61.33 102.64 91.64
98 INT133842 Binding of SOX10 3 0.38 5.79 1.02 91.20
99 INT174101 Protein_catabolism of Ache 3 0.66 2.45 0.22 91.12
100 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 91.00
101 INT30312 Binding of Pdyn 30 0.37 4.2 18.23 90.96
102 INT291677 Transcription of Alox5 1 0.58 3.91 0.91 90.88
103 INT54052 Gene_expression of App 33 0.78 25.08 14.7 90.80
104 INT5016 Negative_regulation of Crh 129 0.59 36.74 59.28 90.64
105 INT119412 Gene_expression of Snca 15 0.66 11.27 3.39 90.64
106 INT210975 Regulation of Cfp 10 0.24 5.3 3.93 90.60
107 INT69075 Regulation of Calb1 6 0.02 2.43 2.31 90.60
108 INT84932 Negative_regulation of APP 29 0.57 28.45 7.2 90.40
109 INT124860 Gene_expression of Bace1 330 0.78 157.11 31.65 90.36
110 INT115386 Gene_expression of Ppara 779 0.77 549.99 128.36 90.32
111 INT91692 Positive_regulation of Binding of ZAK 1 0.44 0.76 0.31 90.04
112 INT293031 Binding of Gluco3 1 0.08 0.86 0.32 89.88
113 INT228662 Gene_expression of Eif4ebp1 2 0.65 0.91 0.26 89.88
114 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82 89.64
115 INT88197 Binding of ZAK 9 0.46 6.23 3.54 89.24
116 INT16651 Localization of SEMA6A 5 0.68 1.72 2.03 88.92
117 INT193832 Localization of Ps 19 0.13 6.96 8.04 88.72
118 INT44378 Gene_expression of GSTM1 69 0.76 34.61 8.81 88.64
119 INT71308 Gene_expression of CCL11 33 0.76 25.66 7.83 88.40
120 INT145949 Gene_expression of CCL24 2 0.54 2.39 0.68 88.40
121 INT145880 Regulation of Regulation of Pgp 1 0.37 1.26 1.45 88.28
122 INT233398 Localization of TIMP3 2 0.45 1.31 0.26 88.16
123 INT183817 Localization of BEST1 6 0.26 5.22 0.16 88.16
124 INT342014 Localization of LPPR1 1 0.06 0.45 0.03 87.72
125 INT342013 Positive_regulation of Localization of LPPR1 1 0.04 0.45 0.03 87.72
126 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 87.60
127 INT86717 Negative_regulation of Positive_regulation of NOS1 18 0.30 8.88 5.2 87.60
128 INT197322 Protein_catabolism of Apoe 6 0.71 3.52 0.51 87.60
129 INT31719 Negative_regulation of Ctsa 6 0.47 6.1 1.43 87.56
130 INT22128 Positive_regulation of HIVEP1 61 0.43 70.52 6.07 87.44
131 INT98624 Regulation of Aqp4 27 0.62 30.76 3.77 87.36
132 INT69570 Binding of Prnp 75 0.48 44.26 4.37 87.36
133 INT159140 Positive_regulation of Gene_expression of Tjp1 11 0.61 5.04 0.5 87.36
134 INT190664 Regulation of Binding of Prnp 3 0.52 4.29 0.1 87.36
135 INT159144 Positive_regulation of Gene_expression of Ocln 1 0.27 1.04 0.09 87.36
136 INT168409 Positive_regulation of Ccl5 47 0.64 45.84 10.83 87.32
137 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 87.20
138 INT149031 Gene_expression of Tjp1 43 0.75 19.1 2.06 87.08
139 INT159143 Gene_expression of Ocln 14 0.42 5.25 0.57 87.08
140 INT68267 Gene_expression of CACNA1A 22 0.75 11.39 8.65 87.04
141 INT103959 Gene_expression of ATP1A2 3 0.67 2.47 1.68 87.04
142 INT9292 Positive_regulation of SGCG 93 0.67 35.13 23.48 86.96
143 INT10879 Positive_regulation of Avp 39 0.65 14.01 8.76 86.60
144 INT278418 Binding of Emp1 1 0.27 0.47 0.26 86.52
145 INT342020 Positive_regulation of LPPR1 1 0.05 1.75 0.2 86.48
146 INT149292 Localization of NOTCH1 7 0.54 6.11 1.14 86.40
147 INT149294 Regulation of Localization of NOTCH1 1 0.10 0.9 0.55 86.40
148 INT189477 Positive_regulation of Ccr3 1 0.49 4.8 0.72 86.32
149 INT111073 Gene_expression of Psen1 167 0.76 78.65 15.83 86.08
150 INT193863 Gene_expression of Ncstn 7 0.29 3.88 0.66 86.08
151 INT237402 Positive_regulation of Gene_expression of Ncstn 3 0.26 2.78 0.48 86.08
152 INT153268 Positive_regulation of Ccr5 25 0.66 19 7.02 85.96
153 INT181507 Positive_regulation of Psen1 22 0.49 7.59 2.04 85.68
154 INT149295 Regulation of NOTCH1 10 0.13 4.26 1.22 85.68
155 INT11325 Gene_expression of HLA-E 209 0.76 98.05 33.72 85.48
156 INT27762 Positive_regulation of Gene_expression of EPO 18 0.70 17.67 1.45 85.44
157 INT113996 Gene_expression of RS1 23 0.72 7.7 3.16 85.36
158 INT316044 Positive_regulation of Ncstn 1 0.20 1.37 0.32 85.36
159 INT159141 Negative_regulation of Gene_expression of Tjp1 7 0.57 5.44 0.62 85.20
160 INT159145 Negative_regulation of Gene_expression of Ocln 4 0.32 3.07 0.34 85.20
161 INT5503 Negative_regulation of Gene_expression of Crh 38 0.59 16.82 21.34 85.12
162 INT47712 Positive_regulation of App 135 0.69 101.38 28.94 85.04
163 INT65500 Gene_expression of App 605 0.78 429.94 98.31 84.92
164 INT103882 Gene_expression of MECP2 17 0.76 10.47 0.96 84.80
165 INT69217 Gene_expression of Notch1 20 0.78 7.8 4.41 84.72
166 INT46016 Gene_expression of Ngfr 69 0.77 41.22 19.8 84.48
167 INT283838 Gene_expression of Erbb4 5 0.59 2.37 0.42 84.48
168 INT316046 Gene_expression of Ephb2 1 0.47 0.57 0.23 84.48
169 INT169205 Gene_expression of Ps 23 0.58 15.88 9.99 84.40
170 INT180497 Binding of MRI1 45 0.42 28.35 14.77 84.40
171 INT122500 Protein_catabolism of Slco1c1 17 0.52 16.7 1.7 84.12
172 INT82448 Gene_expression of S100a8 246 0.77 236.72 84.02 84.12
173 INT71633 Negative_regulation of SLC6A3 25 0.59 10.5 10.69 83.80
174 INT163405 Positive_regulation of Binding of ROS1 15 0.27 9.39 2.58 83.68
175 INT228659 Phosphorylation of Eif4ebp1 10 0.80 27.53 6.87 83.44
176 INT134915 Binding of Aif1 4 0.36 1.72 1.72 83.44
177 INT335734 Binding of Sh2b1 1 0.06 0.83 0.13 83.44
178 INT262476 Gene_expression of Aqp8 21 0.34 7.94 2.76 83.28
179 INT104564 Gene_expression of Aqp3 8 0.65 4.92 1.99 83.28
180 INT235939 Gene_expression of Aqp5 8 0.45 4.7 1.06 83.28
181 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 83.20
182 INT335731 Gene_expression of Vcp 1 0.73 12.21 0.18 83.16
183 INT335729 Gene_expression of Vmn1r155 1 0.01 2.54 0 83.16
184 INT149296 Negative_regulation of CDC42BPA 1 0.01 0.91 0.55 83.12
185 INT94784 Binding of ROS1 113 0.40 71.57 10.26 83.04
186 INT264244 Gene_expression of Cpz 10 0.58 3.24 1.09 82.44
187 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 82.36
188 INT172808 Positive_regulation of Positive_regulation of ROS1 35 0.40 31.39 2.27 82.36
189 INT26472 Regulation of Oprm1 191 0.62 35.84 173.1 82.00
190 INT53083 Gene_expression of Ptgs2 153 0.78 90.04 50.39 81.76
191 INT9973 Binding of MMVP1 14 0.48 22.66 1.79 81.52
192 INT193836 Regulation of Ps 4 0.09 1.89 1.5 81.48
193 INT76698 Positive_regulation of Pgp 7 0.42 7.37 6.02 81.44
194 INT151168 Gene_expression of Pten 60 0.78 35.63 10.54 81.44
195 INT85965 Binding of Cd40lg 26 0.45 16.76 4.52 81.44
196 INT151171 Positive_regulation of Pten 20 0.55 13.3 3.54 81.44
197 INT145879 Positive_regulation of Gene_expression of Pgp 2 0.30 1.23 1.63 81.44
198 INT151169 Positive_regulation of Gene_expression of Pten 15 0.45 12.88 1.53 81.44
199 INT105287 Positive_regulation of Slco1c1 24 0.34 15.41 6.81 81.28
200 INT106721 Regulation of Adcy1 6 0.45 2.32 4.17 81.16
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