D:Brain Ischemia

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Disease Term
Synonyms Brain Ischemias, Cerebral Ischemia, Cerebral Ischemias, ENCEPHALOPATHY ISCHEMIC, Ischemia Brain, Ischemia Cerebral, Ischemias Cerebral, Ischemic Encephalopathies, Ischemic Encephalopathy
Documents 50
Hot Single Events 26
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Brain Ischemia. They are ordered first by their relevance to Brain Ischemia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT319119 SERPINE1 Negative_regulation of Positive_regulation of PLG 1 0.11 1.56 0.15 39.84
2 INT350213 Binding of Rab33b and Atg16l1 1 0.37 0.28 0.07 6.08
3 INT317836 Binding of Fibp and Pycard 1 0.00 2.68 0.98 5.00
4 INT317832 Binding of Mefv and Il1 1 0.03 3.89 0.7 5.00
5 INT317834 Binding of Pstpip1 and Il1 1 0.00 2.03 0.48 5.00
6 INT278379 Binding of Pstpip1 and Mefv 3 0.03 2.02 0.48 5.00
7 INT162954 Sema6a Regulation of Scn7a 1 0.10 0.55 0.46 5.00
8 INT317835 Nlrp3 Positive_regulation of Il18 1 0.08 1.49 0.31 5.00
9 INT317833 Nlrp3 Positive_regulation of Localization of Il1 1 0.06 1.38 0.26 5.00
10 INT317831 Binding of Mefv and Nlrx1 1 0.00 1.77 0.2 5.00
11 INT292750 Akt1 Positive_regulation of Bcl2 1 0.01 1.67 0.15 5.00
12 INT292749 Akt1 Positive_regulation of Ctnnd2 1 0.09 1.73 0.15 5.00
13 INT292748 Akt1 Negative_regulation of Positive_regulation of Casp3 1 0.01 1.81 0.15 5.00
14 INT259023 CADPS Positive_regulation of Binding of SH2B2 1 0.06 2.05 0.14 5.00
15 INT348686 Plg Positive_regulation of Protein_catabolism of Ecm1 1 0.02 0.17 0.09 5.00
16 INT348690 Atp9a Positive_regulation of Gene_expression of Fgf2 1 0.00 0.21 0.05 5.00
17 INT319120 CRP Positive_regulation of Gene_expression of SERPINE1 1 0.70 0.54 0.04 5.00
18 INT348694 Atp9a Negative_regulation of Serpine1 1 0.00 0.24 0.03 5.00
19 INT348685 Positive_regulation of Mmp9 Positive_regulation of Protein_catabolism of Plau 1 0.10 0.27 0.03 5.00
20 INT348691 Atp9a Positive_regulation of Plau 1 0.00 0.31 0.03 5.00
21 INT348687 Fgf2 Regulation of Gene_expression of Plau 1 0.14 0 0 5.00
22 INT348688 Fgf2 Regulation of Plau 1 0.14 0 0 5.00
23 INT348693 Atp9a Positive_regulation of Fgf2 1 0.00 0.07 0 5.00
24 INT348689 Fgf2 Regulation of Map3k1 1 0.09 0 0 5.00
25 INT348692 Atp9a Positive_regulation of Gene_expression of Mmp9 1 0.00 0.07 0 5.00
26 INT348695 Atp9a Positive_regulation of Mmp9 1 0.00 0.07 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Brain Ischemia. They are ordered first by their pain relevance and then by number of times they were reported in Brain Ischemia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 99.72
2 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 99.72
3 INT75999 Gene_expression of BDNF 344 0.78 114.19 83.12 99.36
4 INT103469 Positive_regulation of Gene_expression of BDNF 59 0.67 24.39 18.36 99.36
5 INT74389 Gene_expression of Gdnf 131 0.78 58.52 57.06 99.12
6 INT79981 Positive_regulation of Gene_expression of Gdnf 27 0.70 12.49 10.77 99.12
7 INT61680 Positive_regulation of PVR 23 0.60 23.27 3.86 98.84
8 INT64346 Positive_regulation of S100B 95 0.70 63.11 9.17 97.04
9 INT28929 Negative_regulation of PVR 22 0.57 16.64 1.07 96.60
10 INT102187 Gene_expression of SH2B2 23 0.59 26.54 4.39 95.92
11 INT92001 Regulation of Gene_expression of Gdnf 12 0.62 6.62 6.65 95.28
12 INT125766 Regulation of S100b 7 0.38 4.31 1.33 94.28
13 INT28182 Gene_expression of Acla1 1 0.56 1.15 0.4 93.96
14 INT350211 Gene_expression of Tfb2m 1 0.08 0.71 0.35 93.96
15 INT11361 Gene_expression of SERPINE1 183 0.78 136.45 27.97 93.64
16 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 93.64
17 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 93.64
18 INT62400 Positive_regulation of Localization of Il1 34 0.67 35.53 7.96 93.36
19 INT19775 Localization of Il1 183 0.78 145.5 50.91 92.96
20 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 92.56
21 INT77793 Positive_regulation of Gdnf 54 0.70 23.76 25.08 92.56
22 INT211830 Binding of PVR 3 0.32 2.26 0.03 90.88
23 INT141148 Gene_expression of BMP7 24 0.71 14.34 3.44 90.44
24 INT84932 Negative_regulation of APP 29 0.57 28.45 7.2 87.80
25 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05 81.68
26 INT8111 Localization of EPO 32 0.81 19.53 2.54 80.88
27 INT45597 Negative_regulation of Epo 22 0.59 12.47 2.35 78.28
28 INT82883 Positive_regulation of Ccl2 105 0.69 84.96 42.27 76.24
29 INT11012 Positive_regulation of Creb1 258 0.70 84.4 132 75.00
30 INT69764 Positive_regulation of Cnr1 126 0.70 67.8 91.49 75.00
31 INT76621 Positive_regulation of Cnr2 32 0.69 17.77 26.57 75.00
32 INT16260 Gene_expression of Bdnf 671 0.78 283.44 339.1 75.00
33 INT11009 Phosphorylation of Creb1 458 0.82 111.34 221.97 75.00
34 INT16253 Positive_regulation of Gene_expression of Bdnf 196 0.70 92.67 113.01 75.00
35 INT11011 Positive_regulation of Phosphorylation of Creb1 190 0.70 49.25 112.01 75.00
36 INT48244 Gene_expression of Il4 172 0.76 132.38 73.42 75.00
37 INT106175 Positive_regulation of Positive_regulation of Creb1 37 0.70 13.89 22.46 75.00
38 INT60044 Gene_expression of Syn1 38 0.78 4.98 14.61 75.00
39 INT63401 Gene_expression of Il5 33 0.72 18.66 8.2 75.00
40 INT63727 Positive_regulation of Gene_expression of Syn1 4 0.50 2.1 3.31 75.00
41 INT35584 Binding of ACLY 22 0.35 31.78 7.17 69.60
42 INT36221 Positive_regulation of Nlrp3 25 0.68 19.7 4.5 69.24
43 INT28183 Positive_regulation of Acla1 1 0.66 0.88 0.23 68.32
44 INT6810 Gene_expression of ENO2 70 0.78 54.8 8.35 55.68
45 INT85285 Positive_regulation of Gene_expression of ENO2 4 0.50 4.15 0.61 55.68
46 INT15652 Positive_regulation of ENO2 37 0.68 33.39 5.02 55.28
47 INT350209 Gene_expression of Rab33b 1 0.78 1.87 0.86 52.16
48 INT168641 Gene_expression of Iba1 24 0.63 12.21 6.7 51.20
49 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 51.00
50 INT82169 Negative_regulation of S100b 2 0.31 0.69 0.08 50.56
51 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 50.00
52 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 50.00
53 INT82878 Gene_expression of Ccl2 201 0.78 164.95 101.35 50.00
54 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 50.00
55 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 50.00
56 INT77652 Negative_regulation of Gene_expression of IL8 99 0.59 67.57 30.21 50.00
57 INT82882 Localization of Ccl2 61 0.80 41.96 28 50.00
58 INT48853 Positive_regulation of BDNF 82 0.69 43.92 27.99 50.00
59 INT69157 Gene_expression of IL5 127 0.77 102.58 26.81 50.00
60 INT48144 Gene_expression of Fgf2 117 0.78 43 20.48 50.00
61 INT68683 Regulation of Gene_expression of VEGFA 143 0.62 104.19 20.14 50.00
62 INT8423 Gene_expression of Cntf 29 0.69 11.69 8.4 50.00
63 INT56404 Gene_expression of EDA 16 0.75 7.09 4.24 50.00
64 INT81458 Positive_regulation of Cntf 11 0.47 4.18 3.18 50.00
65 INT287241 Positive_regulation of BMP7 10 0.43 2.68 1.38 50.00
66 INT141150 Localization of BMP7 4 0.56 2.84 0.76 50.00
67 INT186511 Gene_expression of ABRA 1 0.19 1.92 0.42 40.16
68 INT11636 Positive_regulation of SERPINE1 85 0.69 68.73 14.8 39.84
69 INT4561 Gene_expression of PLG 32 0.75 17.59 6.21 39.84
70 INT12104 Positive_regulation of PLG 45 0.68 28.94 4.81 39.84
71 INT17741 Gene_expression of MBP 67 0.78 23.67 9.65 37.84
72 INT194242 Positive_regulation of Gene_expression of MBP 9 0.45 4.1 1.71 37.84
73 INT541 Positive_regulation of MBP 31 0.67 28.56 12.24 37.44
74 INT350208 Localization of Rab33b 1 0.75 1.11 0.44 36.64
75 INT11360 Localization of SERPINE1 41 0.80 33.98 5.61 33.12
76 INT72924 Negative_regulation of MCRS1 27 0.19 33.59 10.29 30.16
77 INT106745 Localization of CRP 65 0.81 66.44 15.21 26.64
78 INT17493 Binding of Ar 14 0.48 3.62 0.6 23.28
79 INT74425 Gene_expression of SPHAR 8 0.08 7.81 2.15 18.92
80 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 18.00
81 INT350207 Positive_regulation of Rab33b 1 0.69 2.43 0.91 17.76
82 INT63932 Positive_regulation of Ephb1 537 0.70 259.67 296.14 5.00
83 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
84 INT22548 Positive_regulation of Casp3 483 0.70 258.78 213.07 5.00
85 INT63934 Phosphorylation of Ephb1 377 0.82 150.52 188.66 5.00
86 INT94952 Positive_regulation of Mapk14 305 0.70 197.83 186.61 5.00
87 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
88 INT65054 Positive_regulation of Nfkb1 285 0.70 149.33 126.73 5.00
89 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
90 INT48923 Gene_expression of Ephb1 211 0.77 106.23 109.9 5.00
91 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
92 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
93 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
94 INT97701 Phosphorylation of Mapk14 191 0.82 115.33 100.46 5.00
95 INT94953 Negative_regulation of Mapk14 156 0.59 104.77 91.51 5.00
96 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 5.00
97 INT10166 Localization of Tnf 237 0.81 153.95 88.64 5.00
98 INT54571 Positive_regulation of NFKB1 263 0.70 138.99 87.32 5.00
99 INT99070 Gene_expression of Mapk14 147 0.78 103.99 79.59 5.00
100 INT17546 Negative_regulation of Ngf 135 0.59 60.28 77.19 5.00
101 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 5.00
102 INT55344 Gene_expression of Ros1 396 0.54 217.64 59.98 5.00
103 INT48891 Positive_regulation of Il10 143 0.70 101.42 56.72 5.00
104 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03 5.00
105 INT117713 Phosphorylation of Akt1 275 0.82 95.82 54.34 5.00
106 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 5.00
107 INT49552 Negative_regulation of Positive_regulation of Casp3 76 0.55 36.04 44.78 5.00
108 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 5.00
109 INT27798 Gene_expression of Ntrk2 111 0.78 56.08 42.68 5.00
110 INT50957 Negative_regulation of Il6 134 0.59 79.08 42.67 5.00
111 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 5.00
112 INT173693 Localization of Gopc 249 0.65 70.49 38.81 5.00
113 INT68975 Gene_expression of Mmp9 111 0.78 79.57 38.55 5.00
114 INT11439 Positive_regulation of Csf2 105 0.69 62.63 37.77 5.00
115 INT97702 Positive_regulation of Phosphorylation of Mapk14 69 0.69 49.21 36.81 5.00
116 INT84260 Positive_regulation of Mapk8 124 0.69 72.84 35.98 5.00
117 INT95734 Phosphorylation of Mapk8 108 0.82 49.92 33.52 5.00
118 INT63935 Positive_regulation of Gene_expression of Ephb1 52 0.61 24.3 33.05 5.00
119 INT17886 Negative_regulation of Il1 95 0.57 70.91 31.25 5.00
120 INT56809 Binding of Tlr4 184 0.48 106.02 31.18 5.00
121 INT72923 Positive_regulation of MCRS1 72 0.50 99.19 30.36 5.00
122 INT68973 Positive_regulation of Mmp9 89 0.52 58.56 30.04 5.00
123 INT9199 Positive_regulation of CEBPZ 111 0.67 30.99 28.45 5.00
124 INT112707 Negative_regulation of Akt1 89 0.59 28.85 27.76 5.00
125 INT14690 Localization of CSF2 124 0.80 85.17 27.26 5.00
126 INT605 Regulation of Acot1 61 0.62 10.7 26.34 5.00
127 INT76095 Positive_regulation of ISYNA1 117 0.55 79.73 25.86 5.00
128 INT70048 Positive_regulation of Gene_expression of IL10 90 0.55 71.34 25.66 5.00
129 INT40776 Gene_expression of Akt1 99 0.77 34.91 24.39 5.00
130 INT15511 Gene_expression of Tnfrsf1a 84 0.76 63.3 24.03 5.00
131 INT25607 Binding of Il1 82 0.47 64.4 23.9 5.00
132 INT99069 Positive_regulation of Gene_expression of Mapk14 42 0.53 29.84 23.16 5.00
133 INT23257 Regulation of CRP 127 0.62 100.05 21.87 5.00
134 INT16396 Negative_regulation of CEBPZ 76 0.48 30.03 21.6 5.00
135 INT99068 Gene_expression of Mapk8 62 0.78 33.57 21.25 5.00
136 INT82434 Positive_regulation of LEP 117 0.70 95.45 20.22 5.00
137 INT20129 Regulation of Il1 53 0.53 44.14 19.89 5.00
138 INT78024 Gene_expression of ACLY 73 0.75 59.15 18.54 5.00
139 INT93734 Positive_regulation of Gene_expression of Bcl2 76 0.70 61.95 18.46 5.00
140 INT18010 Positive_regulation of CD40LG 122 0.70 100.8 18.46 5.00
141 INT86673 Positive_regulation of Bcl2 77 0.70 57.74 17.37 5.00
142 INT104493 Negative_regulation of Mapk8 56 0.53 27.76 16.86 5.00
143 INT77620 Gene_expression of Fas 146 0.78 72.4 16.61 5.00
144 INT1020 Negative_regulation of BCHE 109 0.59 44.86 16.4 5.00
145 INT80972 Gene_expression of Tp53 104 0.78 102.74 16.02 5.00
146 INT2843 Gene_expression of Epo 100 0.78 62.01 14.66 5.00
147 INT61548 Positive_regulation of Fgf2 72 0.70 32.18 14.49 5.00
148 INT10173 Binding of Tnf 45 0.48 35.6 14.32 5.00
149 INT184890 Regulation of MCRS1 35 0.22 44.35 13.78 5.00
150 INT18012 Gene_expression of EPO 169 0.78 108.36 13.75 5.00
151 INT15921 Positive_regulation of Serpine1 85 0.68 81.24 13.4 5.00
152 INT69035 Positive_regulation of Casp1 43 0.69 25.18 10.67 5.00
153 INT43009 Gene_expression of Scn7a 45 0.68 7.85 10.29 5.00
154 INT99505 Gene_expression of Bcl2l1 42 0.77 33.12 10.15 5.00
155 INT25608 Regulation of Gene_expression of Il1 37 0.44 27.76 10.1 5.00
156 INT169997 Positive_regulation of Gene_expression of Tp53 37 0.70 47.3 9.85 5.00
157 INT38564 Binding of AIS 36 0.38 27.77 9.31 5.00
158 INT120967 Negative_regulation of Phosphorylation of Akt1 47 0.57 23.67 8.98 5.00
159 INT55342 Negative_regulation of Gene_expression of Ros1 49 0.37 31.62 8.93 5.00
160 INT6499 Localization of Ntrk2 44 0.79 11.78 8.75 5.00
161 INT104481 Regulation of Mapk8 21 0.50 13.87 8.41 5.00
162 INT39457 Positive_regulation of SOAT1 32 0.67 22.8 8.28 5.00
163 INT25152 Gene_expression of SAA1 37 0.75 53.56 8.07 5.00
164 INT99071 Positive_regulation of Gene_expression of Mapk8 16 0.55 9.87 7.58 5.00
165 INT17501 Negative_regulation of F2 70 0.58 32.23 7.51 5.00
166 INT26462 Gene_expression of DNAH8 44 0.78 19.36 7.31 5.00
167 INT4228 Gene_expression of CAT 50 0.75 20.62 7.18 5.00
168 INT91509 Localization of CYC1 39 0.78 34.74 7.17 5.00
169 INT54662 Positive_regulation of Positive_regulation of Il1 21 0.43 19.33 7.14 5.00
170 INT147583 Gene_expression of AIS 82 0.58 48.7 7.11 5.00
171 INT17029 Regulation of Scn7a 23 0.45 3.89 7.02 5.00
172 INT16395 Gene_expression of CEBPZ 30 0.57 11.02 6.66 5.00
173 INT71116 Gene_expression of Plau 29 0.77 4.94 6.45 5.00
174 INT171691 Protein_catabolism of Ecm1 31 0.20 11.57 6.38 5.00
175 INT90077 Gene_expression of Casp1 29 0.76 20.79 6.26 5.00
176 INT8683 Positive_regulation of F3 31 0.67 42.89 6.21 5.00
177 INT64689 Positive_regulation of Gene_expression of Fgf2 30 0.70 12.05 6.2 5.00
178 INT3738 Regulation of Epo 25 0.61 13.73 6.18 5.00
179 INT157932 Positive_regulation of ADHD1 46 0.48 52.18 6.13 5.00
180 INT56149 Localization of CD8A 56 0.74 30.41 5.75 5.00
181 INT100422 Negative_regulation of Gene_expression of Bcl2 46 0.58 28.86 5.7 5.00
182 INT118870 Positive_regulation of STAT1 36 0.67 26.18 5.46 5.00
183 INT112713 Gene_expression of Hif1a 24 0.75 20.48 5.45 5.00
184 INT114180 Negative_regulation of Il1rn 22 0.57 11.06 5.44 5.00
185 INT95120 Positive_regulation of CASP9 76 0.67 67.55 5.33 5.00
186 INT174688 Binding of Tlr2 45 0.42 36.65 5.25 5.00
187 INT6476 Gene_expression of TNFRSF1B 21 0.67 18.22 5.25 5.00
188 INT57368 Regulation of ADHD1 39 0.50 42.23 5.01 5.00
189 INT1901 Binding of Mefv 24 0.48 32.26 4.5 5.00
190 INT11634 Regulation of SERPINE1 24 0.62 20.06 4.26 5.00
191 INT45975 Positive_regulation of SAA1 17 0.67 19.7 4.15 5.00
192 INT104221 Regulation of Gene_expression of CRP 30 0.45 20.01 4.07 5.00
193 INT17548 Negative_regulation of Serpine1 30 0.57 24.69 3.93 5.00
194 INT48143 Gene_expression of Fgf1 32 0.78 8.2 3.72 5.00
195 INT93399 Gene_expression of Ccnd1 38 0.58 21 3.65 5.00
196 INT105222 Positive_regulation of Plau 18 0.54 8.52 3.5 5.00
197 INT87517 Gene_expression of LDLR 73 0.69 37.35 3.32 5.00
198 INT61547 Regulation of Fgf2 21 0.47 7.23 3.24 5.00
199 INT175262 Binding of SH2B2 18 0.36 22.85 3.18 5.00
200 INT77670 Positive_regulation of ACLY 24 0.49 21.68 3.12 5.00
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