D:Brain Stem Neoplasms

From wiki-pain
Jump to: navigation, search

pChart

Disease Term
Synonyms BRAIN STEM NEOPLASM, Brain Stem Neoplasms Primary, Brain Stem Tumor, Brain Stem Tumors, Brainstem Neoplasm, Brainstem Neoplasm Primary, Brainstem Neoplasms, Brainstem Neoplasms Primary, BRAINSTEM TUMOR, BRAINSTEM TUMORS, Medullary Neoplasm
Documents 43
Hot Single Events 3
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Brain Stem Neoplasms. They are ordered first by their relevance to Brain Stem Neoplasms and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT173059 Binding of KDR and VEGFA 43 0.43 29.63 1.1 5.00
2 INT71904 Binding of ESR1 and PGR 6 0.34 3.79 0.27 5.00
3 INT220697 Binding of CHRNE and DBP 1 0.02 1.15 0.08 5.00
4 INT220698 Binding of CHRNE and SFTPA1 1 0.01 0.75 0.06 5.00
5 INT314686 TP53 Regulation of Gene_expression of MDM2 1 0.21 0.96 0.03 5.00
6 INT314677 TP53 Regulation of Positive_regulation of CDKN2A 1 0.27 0.97 0.03 5.00
7 INT314690 TP53 Regulation of Gene_expression of ZBTB7A 1 0.33 0.97 0.03 5.00
8 INT289608 Binding of CDK2 and CCNE2 5 0.06 4.89 0 5.00
9 INT314746 Akt1 Positive_regulation of Phosphorylation of MDM2 1 0.32 1.16 0 5.00
10 INT314741 Binding of VEGFA and Akt1 1 0.36 0.66 0 5.00
11 INT314692 Binding of TBX2 and TBX3 1 0.27 0.84 0 5.00
12 INT314742 Binding of RAD51 and Brca2 1 0.06 1.05 0 5.00
13 INT314693 Binding of TBX2 and TBX5 1 0.16 0.84 0 5.00
14 INT314743 Binding of RAD51 and Brca1 1 0.06 1.06 0 5.00
15 INT314740 Binding of ESR1 and Brca1 1 0.16 0.69 0 5.00
16 INT314682 Binding of TBX2 and TBX4 1 0.16 0.84 0 5.00
17 INT314687 ESR1 Regulation of PGR 1 0.27 0.88 0 5.00
18 INT314683 NUDT6 Positive_regulation of FGF1 1 0.02 1.17 0 5.00
19 INT314744 Binding of KDR and Akt1 1 0.13 0.66 0 5.00
20 INT314688 Binding of CCNE1 and CDK2 1 0.04 1.41 0 5.00
21 INT314678 Binding of CCNE1 and CCNE2 1 0.03 1.41 0 5.00
22 INT314745 Binding of TP53 and Brca1 1 0.18 1.17 0 5.00
23 INT314689 Binding of KITLG and UBR1 1 0.00 0.71 0 5.00
24 INT314691 ERBB2 Negative_regulation of TP53 1 0.28 1.23 0 5.00
25 INT314685 TBX2 Negative_regulation of CDKN2A 1 0.32 1.16 0 5.00
26 INT314680 Positive_regulation of TBX2 Negative_regulation of CDKN2A 1 0.34 1.16 0 5.00
27 INT314679 NEU1 Negative_regulation of TP53 1 0.12 1.23 0 5.00
28 INT314684 Binding of CCND1 and ESR1 1 0.22 0.42 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Brain Stem Neoplasms. They are ordered first by their pain relevance and then by number of times they were reported in Brain Stem Neoplasms. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 95.44
2 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 85.28
3 INT27242 Gene_expression of PGR 153 0.75 98.77 12.79 85.16
4 INT177586 Positive_regulation of Gene_expression of MRI1 9 0.33 4.97 2.91 79.52
5 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 75.52
6 INT57748 Positive_regulation of Gene_expression of TP53 85 0.69 79.55 7.49 75.52
7 INT102813 Regulation of Gene_expression of TP53 25 0.59 25.95 0.75 75.52
8 INT6530 Regulation of Abr 7 0.24 0.46 2.01 75.00
9 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 63.44
10 INT12250 Negative_regulation of Mtr 19 0.50 6.9 5.35 62.12
11 INT29635 Localization of Eno2 9 0.76 6.05 1.35 60.48
12 INT60585 Regulation of TP53 59 0.59 54.55 5.21 57.60
13 INT70265 Regulation of MRI1 42 0.39 30.95 14.18 52.40
14 INT97624 Positive_regulation of Adc 13 0.69 5.56 4.87 49.84
15 INT88464 Negative_regulation of CST7 11 0.31 5.33 2.17 43.04
16 INT97623 Negative_regulation of Adc 17 0.56 3.81 8.14 36.16
17 INT282214 Negative_regulation of Gene_expression of Adc 2 0.07 1.34 0.21 36.16
18 INT282215 Negative_regulation of Regulation of Adc 1 0.07 0.39 0.04 36.16
19 INT51083 Gene_expression of Adc 14 0.53 8.24 2.25 35.76
20 INT206031 Regulation of Adc 7 0.33 6.85 1.48 35.76
21 INT2597 Negative_regulation of ACHE 82 0.59 46.36 8.62 5.76
22 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
23 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 5.00
24 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
25 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
26 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
27 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
28 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82 5.00
29 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
30 INT14823 Gene_expression of MET 103 0.75 51.92 32.48 5.00
31 INT5117 Negative_regulation of Gene_expression of IL2 118 0.59 52.33 29.96 5.00
32 INT20462 Binding of ESR1 210 0.44 102.7 26.34 5.00
33 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 5.00
34 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52 5.00
35 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 5.00
36 INT56749 Gene_expression of PCNA 219 0.77 111.25 18.42 5.00
37 INT68681 Transcription of VEGFA 132 0.71 80.47 17.03 5.00
38 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79 5.00
39 INT92354 Localization of ESR1 77 0.75 33.04 15.51 5.00
40 INT73916 Gene_expression of Esr1 58 0.77 26.59 15.15 5.00
41 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36 5.00
42 INT94774 Regulation of CDKN2A 43 0.60 44.41 13.99 5.00
43 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61 5.00
44 INT79545 Positive_regulation of Gene_expression of ESR1 82 0.64 39.42 12.18 5.00
45 INT170601 Positive_regulation of Gene_expression of GOPC 122 0.43 42.79 11.68 5.00
46 INT1118 Gene_expression of C6orf25 73 0.77 47.24 9.1 5.00
47 INT36798 Gene_expression of Mki67 178 0.77 132 8.24 5.00
48 INT15687 Regulation of ESR1 91 0.60 40.42 7.95 5.00
49 INT24978 Binding of SFTPA1 22 0.47 15.09 7.76 5.00
50 INT1150 Gene_expression of ecs 42 0.59 29.38 7.73 5.00
51 INT182440 Gene_expression of CCNE2 39 0.53 22.07 7.44 5.00
52 INT1126 Negative_regulation of CD79A 46 0.59 31.07 6 5.00
53 INT75501 Gene_expression of CCND1 90 0.76 60.86 5.93 5.00
54 INT20280 Positive_regulation of Esr1 32 0.69 18.37 5.69 5.00
55 INT125467 Positive_regulation of Gene_expression of CDKN2A 35 0.63 39.07 5.56 5.00
56 INT10006 Regulation of Mtr 9 0.23 3.56 5.42 5.00
57 INT89794 Positive_regulation of CDKN2A 58 0.67 50.18 5.38 5.00
58 INT15376 Positive_regulation of Gene_expression of ERBB2 215 0.70 168.54 5.23 5.00
59 INT99549 Gene_expression of CDKN1B 30 0.75 17 5.15 5.00
60 INT11158 Positive_regulation of Gene_expression of EGFR 165 0.70 131.26 4.93 5.00
61 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62 5.00
62 INT133630 Negative_regulation of Gene_expression of ESR1 42 0.52 23.89 4.57 5.00
63 INT75688 Binding of KITLG 24 0.30 11.73 4.06 5.00
64 INT86369 Positive_regulation of Gene_expression of PCNA 40 0.67 26.66 3.57 5.00
65 INT168677 Negative_regulation of ACOT1 14 0.27 6.29 3.52 5.00
66 INT178631 Phosphorylation of ESR1 21 0.75 9.16 3.36 5.00
67 INT20419 Negative_regulation of Gene_expression of MYC 19 0.57 9.7 3.29 5.00
68 INT10353 Positive_regulation of PGR 34 0.70 21.84 3.28 5.00
69 INT75500 Negative_regulation of Gene_expression of CCND1 21 0.57 11.59 3.24 5.00
70 INT8103 Binding of TP53 46 0.44 40.2 2.96 5.00
71 INT51150 Positive_regulation of HTC2 10 0.67 6.8 2.95 5.00
72 INT31541 Regulation of Esr1 15 0.54 4.12 2.82 5.00
73 INT85078 Positive_regulation of PCNA 36 0.49 17.06 2.81 5.00
74 INT90875 Negative_regulation of CCND1 31 0.42 26.22 2.66 5.00
75 INT92141 Negative_regulation of CDKN2A 53 0.57 44.23 2.48 5.00
76 INT34830 Regulation of PGR 14 0.45 6.99 2.32 5.00
77 INT50558 Negative_regulation of PCNA 31 0.57 13.97 2.3 5.00
78 INT37394 Localization of ecs 9 0.34 6.41 2.11 5.00
79 INT120220 Gene_expression of ANIB1 4 0.65 1.82 1.92 5.00
80 INT65855 Localization of TP53 18 0.76 17.08 1.89 5.00
81 INT93886 Positive_regulation of Gene_expression of PGR 19 0.52 15.78 1.89 5.00
82 INT48792 Regulation of ERBB2 48 0.57 36.56 1.8 5.00
83 INT14149 Binding of C6orf25 11 0.48 9.04 1.71 5.00
84 INT65684 Gene_expression of MDM2 30 0.62 24.94 1.55 5.00
85 INT306844 Localization of CCNE2 6 0.21 3.81 1.52 5.00
86 INT52962 Binding of ERBB2 77 0.47 50.03 1.49 5.00
87 INT96838 Negative_regulation of Gene_expression of ERBB2 25 0.57 15.83 1.34 5.00
88 INT63905 Regulation of RB1 13 0.62 12.67 1.28 5.00
89 INT201466 Positive_regulation of Gene_expression of CCNE2 13 0.20 8.62 1.26 5.00
90 INT8511 Localization of Esr1 6 0.80 3.27 1.26 5.00
91 INT160013 Gene_expression of CCND2 7 0.42 5.98 1.18 5.00
92 INT142829 Transcription of CREB1 9 0.46 3.37 1.03 5.00
93 INT86559 Negative_regulation of KITLG 8 0.41 3.54 0.99 5.00
94 INT11160 Regulation of Gene_expression of EGFR 27 0.62 22.05 0.96 5.00
95 INT44375 Negative_regulation of ZBTB7A 3 0.57 0.95 0.95 5.00
96 INT201465 Positive_regulation of CCNE2 6 0.13 3.13 0.92 5.00
97 INT37105 Binding of CHRNE 3 0.31 6.88 0.87 5.00
98 INT71649 Localization of ERBB2 23 0.78 13.63 0.83 5.00
99 INT70027 Positive_regulation of Gene_expression of C6orf25 10 0.62 7.21 0.83 5.00
100 INT173082 Positive_regulation of Binding of VEGFA 20 0.48 11.16 0.79 5.00
101 INT54546 Binding of CREB1 9 0.41 3.44 0.72 5.00
102 INT69283 Gene_expression of PHEX 25 0.75 7.81 0.64 5.00
103 INT128498 Regulation of CCND1 17 0.39 12.51 0.58 5.00
104 INT94165 Negative_regulation of RB1 30 0.52 27.29 0.51 5.00
105 INT75498 Positive_regulation of Gene_expression of CCND1 21 0.68 19.4 0.51 5.00
106 INT45878 Gene_expression of NEU1 14 0.65 7.28 0.47 5.00
107 INT139399 Regulation of Gene_expression of PCNA 14 0.56 6.06 0.43 5.00
108 INT155490 Binding of Mki67 13 0.19 13.38 0.41 5.00
109 INT69282 Binding of PHEX 4 0.15 1.43 0.41 5.00
110 INT15588 Regulation of PHEX 4 0.26 1.48 0.39 5.00
111 INT189755 Gene_expression of CCND3 42 0.65 10.88 0.39 5.00
112 INT83212 Positive_regulation of Gene_expression of Mki67 21 0.55 17.53 0.39 5.00
113 INT101902 Negative_regulation of Mki67 12 0.39 7.92 0.34 5.00
114 INT36797 Regulation of Mki67 13 0.24 8.76 0.3 5.00
115 INT166755 Localization of PHEX 2 0.73 1.16 0.28 5.00
116 INT282213 Negative_regulation of Regulation of Mtr 1 0.01 0.82 0.27 5.00
117 INT153772 Negative_regulation of Localization of ESR1 7 0.54 4.42 0.27 5.00
118 INT220699 Positive_regulation of CHRNE 5 0.32 2.26 0.26 5.00
119 INT186057 Binding of CCND1 8 0.31 5.92 0.26 5.00
120 INT314729 Regulation of Localization of TP53 1 0.30 2.5 0.25 5.00
121 INT113989 Regulation of Gene_expression of CCND1 11 0.44 7.57 0.24 5.00
122 INT179889 Negative_regulation of CDKN1B 4 0.57 1.71 0.21 5.00
123 INT88744 Positive_regulation of Gene_expression of MDM2 9 0.43 7.82 0.2 5.00
124 INT63067 Localization of MYC 13 0.78 6.93 0.19 5.00
125 INT89690 Binding of Brca2 2 0.37 1.8 0.18 5.00
126 INT89689 Binding of Brca1 2 0.37 2.55 0.18 5.00
127 INT201464 Regulation of CCNE2 3 0.08 2.79 0.16 5.00
128 INT314724 Regulation of Localization of RB1 1 0.15 1.25 0.13 5.00
129 INT197627 Localization of RB1 3 0.69 4.16 0.13 5.00
130 INT37103 Gene_expression of CHRNE 5 0.67 4.32 0.12 5.00
131 INT201462 Binding of CDK2 12 0.39 5.2 0.12 5.00
132 INT314712 Negative_regulation of Localization of MYC 2 0.22 1.43 0.11 5.00
133 INT187590 Gene_expression of Brca1 12 0.65 4.94 0.11 5.00
134 INT284989 Localization of INTS2 2 0.43 1.64 0.11 5.00
135 INT314718 Negative_regulation of Localization of ERBB2 1 0.37 1.13 0.11 5.00
136 INT314714 Negative_regulation of Localization of INTS2 1 0.24 1.14 0.11 5.00
137 INT213913 Gene_expression of NCOA3 3 0.50 1.11 0.1 5.00
138 INT225189 Binding of CCNE2 5 0.10 2.27 0.1 5.00
139 INT220702 Protein_catabolism of CHRNE 1 0.64 1.22 0.08 5.00
140 INT220704 Protein_catabolism of ACOT1 1 0.02 1.19 0.08 5.00
141 INT174155 Negative_regulation of Brca1 4 0.36 1.77 0.07 5.00
142 INT220700 Gene_expression of MUSK 3 0.75 6.67 0.07 5.00
143 INT253882 Positive_regulation of Localization of Esr1 1 0.30 1.21 0.06 5.00
144 INT171527 Gene_expression of NCOR1 3 0.51 0.49 0.06 5.00
145 INT207806 Phosphorylation of Atm 8 0.81 3.07 0.06 5.00
146 INT314713 Positive_regulation of Gene_expression of ZBTB7A 1 0.49 1.92 0.05 5.00
147 INT311668 Regulation of Regulation of TP53 2 0.36 3.58 0.04 5.00
148 INT314711 Positive_regulation of DMTF1 1 0.01 0.95 0.03 5.00
149 INT314732 Positive_regulation of Negative_regulation of DMTF1 1 0.02 0.97 0.03 5.00
150 INT314733 Negative_regulation of DMTF1 1 0.02 0.95 0.03 5.00
151 INT314719 Gene_expression of TBX2 1 0.54 6.86 0.03 5.00
152 INT314737 Gene_expression of ZBTB7A 1 0.75 0.96 0.03 5.00
153 INT314726 Positive_regulation of TBX2 1 0.38 1.15 0 5.00
154 INT314735 Transcription of TBR1 1 0.00 0.8 0 5.00
155 INT314708 Gene_expression of Brca2 1 0.41 1.75 0 5.00
156 INT220701 Regulation of Negative_regulation of ACHE 2 0.25 1.06 0 5.00
157 INT314720 Positive_regulation of BARD1 1 0.17 1.18 0 5.00
158 INT314723 Transcription of TBX6 1 0.34 0.81 0 5.00
159 INT314707 Regulation of Transcription of Brca2 1 0.27 0.56 0 5.00
160 INT314728 Positive_regulation of Binding of CCNE2 1 0.14 0.7 0 5.00
161 INT171516 Gene_expression of NCOA2 4 0.25 0.63 0 5.00
162 INT314706 Transcription of Brca1 1 0.43 0.53 0 5.00
163 INT212457 Phosphorylation of Brca1 2 0.51 0.96 0 5.00
164 INT314709 Negative_regulation of Fbxo4 1 0.41 0.71 0 5.00
165 INT314715 Positive_regulation of Gene_expression of CCND2 2 0.23 1.24 0 5.00
166 INT314710 Gene_expression of ZNF639 1 0.01 1 0 5.00
167 INT314705 Transcription of Brca2 1 0.42 0.56 0 5.00
168 INT314739 Transcription of TBX1 1 0.32 0.8 0 5.00
169 INT314725 Gene_expression of CCNE1 3 0.52 2.45 0 5.00
170 INT189752 Negative_regulation of Gene_expression of CCND3 6 0.09 1.89 0 5.00
171 INT314738 Gene_expression of BRCA3 1 0.30 1.29 0 5.00
172 INT314731 Positive_regulation of Gene_expression of TBX2 1 0.41 3.42 0 5.00
173 INT314716 Positive_regulation of Gene_expression of CCNE1 1 0.16 1.48 0 5.00
174 INT220703 Regulation of MUSK 1 0.34 1.48 0 5.00
175 INT293773 Positive_regulation of Gene_expression of CCND3 9 0.10 2.72 0 5.00
176 INT314734 Regulation of TBX2 1 0.10 1.22 0 5.00
177 INT276370 Phosphorylation of MDM2 2 0.50 1.99 0 5.00
178 INT314717 Positive_regulation of ZNF639 1 0.01 1.12 0 5.00
179 INT314727 Positive_regulation of BAP1 1 0.14 1.18 0 5.00
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox