D:Breast Disease

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Disease Term
Synonyms Breast Disease Endocrine, Breast Diseases, BREAST DISEASES ENDOCRINE, Breast Disorder, Breast Disorders, Disease Breast, Disease Endocrine Breast, DISEASE OF BREAST, DISEASES BREAST, Diseases Endocrine Breast, Endocrine Breast Disease
Documents 244
Hot Single Events 46
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Breast Disease. They are ordered first by their relevance to Breast Disease and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT52836 ESR1 Positive_regulation of HSD17B7 1 0.43 0.41 0.09 87.24
2 INT222299 Binding of CYP19A1 and AIS 2 0.25 1.65 0.31 72.84
3 INT182194 Binding of IL8 and CXCR2 10 0.56 7.14 4.16 54.04
4 INT230336 IL4 Regulation of IL5 2 0.04 0.82 0.67 50.00
5 INT230337 IL1B Regulation of IL5 1 0.04 0.57 0.28 50.00
6 INT230342 IL6 Regulation of IL4 1 0.02 0.57 0.28 50.00
7 INT230333 IL6 Regulation of IL13 1 0.03 0.57 0.28 50.00
8 INT230339 IL6 Regulation of IL5 1 0.03 0.57 0.28 50.00
9 INT230341 IL9 Regulation of IL5 1 0.06 0.57 0.28 50.00
10 INT230334 IL1B Regulation of IL9 1 0.02 0.57 0.28 50.00
11 INT230343 IL1B Regulation of IL13 1 0.02 0.57 0.28 50.00
12 INT230335 IL6 Regulation of IL9 1 0.03 0.57 0.28 50.00
13 INT230340 IL13 Regulation of IL5 1 0.05 0.57 0.28 50.00
14 INT230338 IL1B Regulation of IL4 1 0.02 0.57 0.28 50.00
15 INT234179 Binding of DDR1 and ESR1 1 0.05 0.86 0 36.96
16 INT208572 Binding of IL8 and CXCR1 6 0.33 5.2 3.08 5.00
17 INT181492 NGF Regulation of TRPV1 1 0.21 0.93 1.31 5.00
18 INT181494 TRPV3 Regulation of Gene_expression of NGF 1 0.24 0.7 1.07 5.00
19 INT181493 TRPV4 Regulation of Gene_expression of NGF 1 0.24 0.7 1.07 5.00
20 INT318737 Binding of CXCR1 and CXCL6 1 0.25 1.37 0.67 5.00
21 INT318738 Binding of CXCR2 and CXCL6 1 0.32 1.39 0.67 5.00
22 INT222301 Binding of ERBB2 and ESR1 5 0.36 5.07 0.29 5.00
23 INT71904 Binding of ESR1 and PGR 6 0.34 3.79 0.27 5.00
24 INT192219 CASP3 Regulation of ESR1 1 0.03 1.19 0.19 5.00
25 INT222300 Binding of ERBB2 and PGR 2 0.34 1.89 0.17 5.00
26 INT220394 MRXS5 Positive_regulation of Gene_expression of CYP19A1 1 0.00 0.89 0.09 5.00
27 INT220412 Cpox Positive_regulation of Gene_expression of CYP19A1 1 0.01 0.9 0.09 5.00
28 INT306241 Ins1 Negative_regulation of Gene_expression of PCK1 1 0.00 0.91 0.08 5.00
29 INT306238 Tead1 Regulation of Ins1 1 0.00 1.04 0.05 5.00
30 INT313597 Binding of BRCA2 and TOX3 1 0.11 0.7 0 5.00
31 INT234182 Binding of BRCA2 and PALB2 1 0.41 1.43 0 5.00
32 INT234180 Binding of BRCA1 and BRIP1 1 0.33 1.37 0 5.00
33 INT313596 ESR1 Positive_regulation of Gene_expression of PGR 1 0.05 1 0 5.00
34 INT220411 Ptger2 Positive_regulation of Cyp19a1 1 0.09 0.83 0 5.00
35 INT234178 Binding of BRCA1 and BRCA2 2 0.40 1.52 0 5.00
36 INT220410 Ptger2 Positive_regulation of Rtcd1 1 0.00 0.83 0 5.00
37 INT287268 Binding of ERBB2 and ERBB3 5 0.16 2.74 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Breast Disease. They are ordered first by their pain relevance and then by number of times they were reported in Breast Disease. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT5135 Negative_regulation of GNRH1 106 0.58 36.63 27.71 100.00
2 INT1926 Positive_regulation of PLAT 54 0.66 31.42 6.49 99.92
3 INT1920 Positive_regulation of Positive_regulation of PLAT 3 0.40 2.29 0.22 99.88
4 INT158 Localization of Prl 2431 0.81 378.96 952.2 99.56
5 INT23010 Positive_regulation of CYP19A1 28 0.58 24.18 5.37 99.28
6 INT1922 Positive_regulation of CEACAM7 32 0.70 33.31 2.72 99.00
7 INT119062 Negative_regulation of BRCA1 12 0.49 13.7 1.36 98.88
8 INT147583 Gene_expression of AIS 82 0.58 48.7 7.11 98.24
9 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79 98.00
10 INT78199 Gene_expression of Neu1 65 0.75 62.88 7.16 97.90
11 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 97.90
12 INT144430 Gene_expression of Erbb2 137 0.77 103.87 8.66 97.90
13 INT156 Negative_regulation of Prl 542 0.59 131.97 192.24 97.12
14 INT528 Gene_expression of Prl 693 0.78 217.18 192.2 97.12
15 INT1925 Gene_expression of PLAT 47 0.75 34.76 7.88 96.56
16 INT1921 Gene_expression of CEACAM7 47 0.78 43.23 2.53 96.56
17 INT162 Regulation of Prl 794 0.62 165.01 322.24 95.04
18 INT111113 Binding of CYP19A1 15 0.36 9.17 2.12 94.56
19 INT96034 Negative_regulation of Proc 11 0.33 10.21 1.18 92.84
20 INT172556 Negative_regulation of Localization of Proc 3 0.01 5.81 0.19 92.84
21 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 91.80
22 INT325185 Gene_expression of PPP3R1 1 0.58 1.54 0.14 91.64
23 INT172559 Localization of Proc 16 0.02 21.49 2.08 91.52
24 INT36132 Negative_regulation of pid 12 0.43 15.15 1.73 91.48
25 INT425 Localization of PRL 455 0.81 189.64 144.8 90.84
26 INT100664 Negative_regulation of MKI67 12 0.10 9.77 0 90.76
27 INT14724 Negative_regulation of CYP19A1 233 0.59 96.56 18.26 90.32
28 INT79270 Gene_expression of MKI67 113 0.77 63.52 3.38 89.60
29 INT237250 Regulation of Gene_expression of Fus 1 0.34 1.45 0.11 89.36
30 INT67097 Gene_expression of MIB1 20 0.75 21.06 1.03 89.32
31 INT231240 Gene_expression of Fus 2 0.56 20.05 3.9 88.96
32 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52 88.00
33 INT162380 Negative_regulation of CXCR2 11 0.57 6.98 2.76 87.60
34 INT3725 Localization of Fshb 10 0.68 2.24 1.04 84.00
35 INT15687 Regulation of ESR1 91 0.60 40.42 7.95 83.28
36 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 82.72
37 INT9089 Positive_regulation of Ceacam1 17 0.69 7.09 2.49 81.92
38 INT27575 Positive_regulation of CEACAM1 2 0.45 1.57 0.03 81.92
39 INT154732 Positive_regulation of Pip 7 0.41 5.93 0.6 81.64
40 INT1793 Localization of CGA 379 0.81 67.38 114.69 81.36
41 INT20200 Positive_regulation of Serpinc1 25 0.68 17.08 4.98 81.20
42 INT1919 Regulation of Regulation of CEACAM7 1 0.23 0.98 0.1 80.84
43 INT7475 Positive_regulation of Hdl1 138 0.67 175.81 15.05 80.76
44 INT1924 Regulation of PLAT 11 0.60 6.3 3.16 80.40
45 INT119904 Regulation of CYP19A1 25 0.62 9.36 8.34 80.32
46 INT1923 Regulation of CEACAM7 9 0.41 7.36 0.31 80.08
47 INT2262 Negative_regulation of Lhb 142 0.59 25.47 44.81 77.72
48 INT2629 Localization of Shbg 27 0.72 15.12 3.2 76.88
49 INT44818 Negative_regulation of Localization of Shbg 6 0.53 2.29 1.05 76.88
50 INT325183 Negative_regulation of Binding of PPP3R1 1 0.37 0.61 0.03 76.24
51 INT325181 Binding of PPP3R1 1 0.32 0.86 0.03 76.24
52 INT1794 Regulation of Localization of CGA 136 0.57 13.39 59.07 75.28
53 INT13313 Regulation of PRLR 7 0.07 1.65 4.77 75.00
54 INT157 Positive_regulation of Localization of Prl 790 0.70 104.54 374.78 74.32
55 INT200443 Positive_regulation of AES 27 0.60 22.46 3.22 74.08
56 INT38564 Binding of AIS 36 0.38 27.77 9.31 72.84
57 INT55335 Binding of Cpox 49 0.34 15.48 18.46 71.36
58 INT161 Regulation of Localization of Prl 615 0.62 65.37 298.66 71.08
59 INT5622 Gene_expression of Nppa 101 0.78 49.46 25.31 68.88
60 INT83295 Positive_regulation of Cd68 21 0.39 14.55 2.46 68.64
61 INT127890 Positive_regulation of Negative_regulation of CYP19A1 6 0.50 1.41 0.45 68.16
62 INT27242 Gene_expression of PGR 153 0.75 98.77 12.79 67.76
63 INT79545 Positive_regulation of Gene_expression of ESR1 82 0.64 39.42 12.18 67.76
64 INT15376 Positive_regulation of Gene_expression of ERBB2 215 0.70 168.54 5.23 67.76
65 INT76890 Gene_expression of FGFR2 42 0.65 13.91 1.08 67.76
66 INT99718 Positive_regulation of Gene_expression of FGFR2 9 0.49 4.47 0.12 67.76
67 INT78990 Regulation of Cpox 72 0.57 35.22 18.16 65.32
68 INT10353 Positive_regulation of PGR 34 0.70 21.84 3.28 63.04
69 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 60.80
70 INT191252 Localization of DDR1 4 0.45 3.15 0.04 57.76
71 INT188844 Gene_expression of AES 44 0.58 33.94 5.85 55.68
72 INT237247 Regulation of Mri1 6 0.27 4.64 1.2 53.76
73 INT22128 Positive_regulation of HIVEP1 61 0.43 70.52 6.07 53.20
74 INT16323 Gene_expression of pr 62 0.66 36.14 38.26 53.04
75 INT222308 Regulation of IGF1R 3 0.12 2.18 0 50.68
76 INT117348 Regulation of EGFR 75 0.61 47.73 3.09 50.68
77 INT48792 Regulation of ERBB2 48 0.57 36.56 1.8 50.68
78 INT159 Negative_regulation of Localization of Prl 416 0.59 55.34 171.8 50.00
79 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 50.00
80 INT19856 Gene_expression of CD8A 240 0.75 147.86 26.39 50.00
81 INT2386 Gene_expression of Pgr 112 0.78 45.46 22.19 50.00
82 INT129 Localization of OXTR 51 0.80 11.08 15.36 50.00
83 INT111607 Gene_expression of CDH1 103 0.75 90.45 7.77 50.00
84 INT15131 Gene_expression of CD2 20 0.75 9.47 5.01 50.00
85 INT128 Negative_regulation of Localization of OXTR 7 0.59 2.92 2.86 50.00
86 INT86370 Regulation of CDH1 10 0.54 13.89 0.7 50.00
87 INT159190 Gene_expression of KRT5 31 0.65 26.67 0.56 50.00
88 INT182828 Positive_regulation of HDDC3 5 0.16 0.67 0.55 50.00
89 INT57881 Binding of Tead1 2 0.25 1.63 0.7 48.40
90 INT180580 Binding of HEYL 7 0.17 4.49 1.15 48.16
91 INT46777 Localization of FECD7 1 0.61 2.09 0.16 45.52
92 INT133630 Negative_regulation of Gene_expression of ESR1 42 0.52 23.89 4.57 45.04
93 INT6133 Negative_regulation of Serpinc1 56 0.58 42.8 8.35 44.88
94 INT57252 Negative_regulation of PGR 22 0.43 12.95 3.33 43.28
95 INT167085 Negative_regulation of ERBB2 67 0.57 44.6 1.48 43.28
96 INT96838 Negative_regulation of Gene_expression of ERBB2 25 0.57 15.83 1.34 43.28
97 INT172529 Negative_regulation of Gene_expression of PGR 24 0.48 16.69 1.04 43.28
98 INT180588 Gene_expression of HEYL 13 0.52 8.37 1.19 42.36
99 INT49439 Gene_expression of Cpox 508 0.73 326.97 130.17 42.08
100 INT20462 Binding of ESR1 210 0.44 102.7 26.34 41.32
101 INT92354 Localization of ESR1 77 0.75 33.04 15.51 38.76
102 INT49441 Negative_regulation of Cpox 494 0.59 303.22 177.46 38.00
103 INT78005 Negative_regulation of Binding of Cpox 7 0.31 3.19 1.7 38.00
104 INT50290 Binding of Cpox 29 0.27 17.19 8.01 37.56
105 INT237248 Negative_regulation of Gene_expression of Fus 1 0.32 0.71 0 36.72
106 INT10139 Positive_regulation of F13A1 64 0.56 44.75 9.69 31.04
107 INT899 Gene_expression of F13A1 122 0.70 78.02 16.26 30.24
108 INT24876 Gene_expression of CD34 172 0.78 91.02 12.39 29.40
109 INT21681 Positive_regulation of CD34 54 0.66 33.95 4.14 29.40
110 INT172566 Gene_expression of Brca2 2 0.64 0.43 0.04 28.80
111 INT172565 Gene_expression of Brca1 1 0.59 0.44 0 28.80
112 INT71047 Gene_expression of CYP19A1 122 0.78 68.78 22.21 26.72
113 INT133809 Negative_regulation of Gene_expression of CYP19A1 9 0.43 7.67 2.99 26.72
114 INT439 Localization of Gnrh1 976 0.81 100.96 363.25 25.00
115 INT2122 Negative_regulation of Localization of Gnrh1 226 0.59 26.92 92.04 25.00
116 INT119098 Positive_regulation of TRPV3 20 0.68 10.12 9.01 22.48
117 INT149385 Positive_regulation of TRPV4 11 0.69 7.22 6.02 22.48
118 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 22.12
119 INT28642 Gene_expression of CXCR2 60 0.78 38.69 18.11 20.48
120 INT103547 Gene_expression of TRPV3 47 0.78 17.06 13.34 19.92
121 INT118440 Gene_expression of TRPV4 20 0.71 7.33 6.01 19.92
122 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 19.44
123 INT6884 Negative_regulation of pr 20 0.42 13.18 7.97 14.24
124 INT9196 Gene_expression of PTGS1 215 0.77 96.99 60.5 10.08
125 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81 5.00
126 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 5.00
127 INT9381 Positive_regulation of TRPV1 523 0.70 187.4 276.05 5.00
128 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
129 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
130 INT1114 Localization of Ins1 748 0.80 192.95 165.48 5.00
131 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
132 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 5.00
133 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
134 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
135 INT1760 Gene_expression of PTGER2 524 0.57 226.94 96.4 5.00
136 INT1472 Positive_regulation of Ins1 349 0.69 146.2 86.36 5.00
137 INT62374 Gene_expression of NGF 158 0.78 77.87 76.45 5.00
138 INT3657 Gene_expression of Ins1 514 0.78 321.69 75.76 5.00
139 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 5.00
140 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 5.00
141 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 5.00
142 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03 5.00
143 INT2276 Regulation of Ins1 234 0.61 103.78 54.05 5.00
144 INT5623 Positive_regulation of Nppa 174 0.70 69.96 52.33 5.00
145 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
146 INT89 Positive_regulation of Gast 187 0.70 80.49 42.07 5.00
147 INT67039 Positive_regulation of Cpox 144 0.65 98.4 33.77 5.00
148 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
149 INT9658 Negative_regulation of Gene_expression of Il6 110 0.59 66.29 32.58 5.00
150 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 5.00
151 INT77652 Negative_regulation of Gene_expression of IL8 99 0.59 67.57 30.21 5.00
152 INT23435 Positive_regulation of NGF 54 0.70 32.41 30.11 5.00
153 INT651 Positive_regulation of PTGS1 93 0.69 37.27 29.18 5.00
154 INT2389 Regulation of PTGS1 86 0.61 31.23 28.95 5.00
155 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 5.00
156 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
157 INT1761 Positive_regulation of PTGER2 135 0.49 90.17 26.26 5.00
158 INT50490 Regulation of PTGS2 80 0.48 39.51 25.85 5.00
159 INT10836 Negative_regulation of IL8 95 0.59 52.59 24.71 5.00
160 INT22708 Gene_expression of MUC1 297 0.78 232.71 24.19 5.00
161 INT10835 Regulation of IL8 79 0.49 53.04 24.14 5.00
162 INT17275 Gene_expression of HIVEP1 267 0.75 232.07 24.06 5.00
163 INT9079 Gene_expression of PPBP 52 0.75 31.2 21.52 5.00
164 INT170313 Gene_expression of Mmp1a 50 0.65 38.53 21.36 5.00
165 INT73593 Gene_expression of BAX 173 0.76 147.81 20.94 5.00
166 INT10833 Regulation of Gene_expression of IL8 68 0.62 38.74 18.46 5.00
167 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3 5.00
168 INT10834 Binding of IL8 65 0.48 41.66 16.53 5.00
169 INT84924 Positive_regulation of Gene_expression of NGF 29 0.68 17.91 16.46 5.00
170 INT9197 Binding of PTGS1 44 0.48 18.48 16.26 5.00
171 INT52107 Transcription of IL8 63 0.72 41.66 16.06 5.00
172 INT12950 Gene_expression of Cat 85 0.75 35.94 15.76 5.00
173 INT170335 Gene_expression of INCENP 176 0.54 91.62 15.31 5.00
174 INT109535 Gene_expression of Vegfa 116 0.75 84.61 14.89 5.00
175 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36 5.00
176 INT16321 Gene_expression of Cd3e 111 0.72 49.9 14.21 5.00
177 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61 5.00
178 INT20632 Gene_expression of TNC 72 0.78 30.43 13.16 5.00
179 INT9832 Gene_expression of Shbg 96 0.75 56.71 12.19 5.00
180 INT92574 Gene_expression of CXCL5 51 0.78 24.87 11.89 5.00
181 INT69029 Gene_expression of PTPRC 127 0.75 74.26 11.57 5.00
182 INT66606 Gene_expression of CXCR1 34 0.75 27.79 11.36 5.00
183 INT10798 Positive_regulation of CYP2D6 24 0.56 5.82 11.31 5.00
184 INT1763 Regulation of Gene_expression of PTGER2 43 0.36 23.98 10.95 5.00
185 INT85048 Regulation of NGF 19 0.62 11.61 10.5 5.00
186 INT134625 Gene_expression of Kdr 116 0.71 53.13 10.09 5.00
187 INT144689 Regulation of RCT 49 0.53 25.91 9.6 5.00
188 INT69321 Regulation of Gene_expression of PTGS2 27 0.61 13.27 9.53 5.00
189 INT73596 Positive_regulation of Gene_expression of BAX 43 0.67 40.97 9.22 5.00
190 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 5.00
191 INT80420 Gene_expression of IFI27 145 0.78 63.61 8.83 5.00
192 INT70017 Positive_regulation of BCL2 87 0.67 66.62 8.68 5.00
193 INT109005 Gene_expression of Proc 61 0.75 37.86 8.49 5.00
194 INT70896 Gene_expression of PDGFB 48 0.65 33.55 8.39 5.00
195 INT65959 Positive_regulation of Gene_expression of BCL2 75 0.70 77.3 8.27 5.00
196 INT93844 Gene_expression of Ptgir 19 0.77 12.12 7.66 5.00
197 INT91445 Regulation of Bcl2 50 0.56 38.8 7.41 5.00
198 INT134624 Gene_expression of Flt1 77 0.66 48.86 7.27 5.00
199 INT6210 Binding of Nppa 39 0.47 14.35 7.21 5.00
200 INT30443 Positive_regulation of AIS 30 0.54 22.59 7.2 5.00
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