D:Bronchial Hyperreactivity

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Disease Term
Synonyms Bronchial Hyperreactivities, Hyperreactivities Bronchial, HYPERREACTIVITY BRONCHIAL
Documents 86
Hot Single Events 44
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Bronchial Hyperreactivity. They are ordered first by their relevance to Bronchial Hyperreactivity and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT288537 Binding of Ccr3 and Ccl11 1 0.17 2.92 0.35 89.36
2 INT141979 Calca Negative_regulation of Gene_expression of Il1b 1 0.40 0.62 1.13 75.00
3 INT302985 HIVEP1 Positive_regulation of Positive_regulation of AHR 1 0.06 0.5 0.06 59.28
4 INT302984 MBP Positive_regulation of AHR 1 0.31 0.3 0.06 5.00
5 INT288538 Il2 Positive_regulation of Gene_expression of Bcl2 1 0.04 1.96 0.03 5.00
6 INT214886 Binding of Atcay and FIP1L1 1 0.08 4.06 0 5.00
7 INT214885 Binding of PDGFRA and Atcay 1 0.08 4.05 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Bronchial Hyperreactivity. They are ordered first by their pain relevance and then by number of times they were reported in Bronchial Hyperreactivity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT15674 Positive_regulation of Gene_expression of Tac1 17 0.68 4.97 6.56 99.20
2 INT5061 Negative_regulation of Mme 306 0.59 51.97 136.9 99.08
3 INT5050 Regulation of Localization of Calca 149 0.62 41.25 148.57 99.00
4 INT11773 Gene_expression of Tac1 56 0.77 10 25.72 98.88
5 INT4758 Positive_regulation of Localization of Calca 557 0.70 138.55 411.04 98.74
6 INT3151 Localization of MBP 27 0.80 7.58 2.28 98.72
7 INT113101 Gene_expression of Ccl11 41 0.76 22.36 5.47 98.56
8 INT89294 Gene_expression of Ccr3 53 0.68 43.9 12.62 98.56
9 INT186735 Regulation of Gene_expression of Ccl11 4 0.40 2.07 0.64 98.56
10 INT189475 Regulation of Gene_expression of Ccr3 4 0.32 3.17 0.54 98.56
11 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 98.54
12 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 98.24
13 INT15166 Positive_regulation of Mme 40 0.70 13.01 16.24 98.08
14 INT53577 Negative_regulation of Localization of TNF 110 0.59 59.28 35.23 97.76
15 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 97.72
16 INT6852 Localization of TNF 883 0.81 705.95 270.84 97.20
17 INT13897 Localization of Sst 65 0.81 14.91 32.24 96.32
18 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 94.88
19 INT244226 Binding of Ccl11 4 0.25 1.81 0.65 94.36
20 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 93.72
21 INT302990 Protein_catabolism of MBP 5 0.88 3.75 1.42 93.24
22 INT103061 Positive_regulation of Gene_expression of Ccl5 4 0.35 1.67 1.9 93.08
23 INT89594 Gene_expression of Ccl5 44 0.54 24.08 18.62 92.76
24 INT147413 Regulation of Sstr4 1 0.41 0.78 0.58 92.08
25 INT87687 Positive_regulation of Trpv1 409 0.70 210.24 257.59 91.32
26 INT22000 Positive_regulation of Sst 25 0.70 14.82 13.6 91.32
27 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 90.88
28 INT51151 Positive_regulation of Regulation of Calca 8 0.50 1.77 3.08 90.88
29 INT28265 Positive_regulation of Calca 62 0.70 29.1 41.17 88.56
30 INT5010 Gene_expression of Calca 197 0.78 85.76 118.75 88.56
31 INT114434 Gene_expression of Calcrl 10 0.78 5.81 1.83 88.56
32 INT141977 Positive_regulation of Calcrl 2 0.70 0.93 0.75 88.56
33 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 87.92
34 INT9233 Negative_regulation of Gene_expression of IL1B 114 0.59 56.99 41.82 87.92
35 INT2540 Negative_regulation of Calca 538 0.59 172.11 384.38 87.76
36 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 87.44
37 INT25363 Negative_regulation of Trpv1 144 0.59 64.78 75.7 87.40
38 INT110365 Negative_regulation of Positive_regulation of Mme 1 0.39 0.09 0.32 86.72
39 INT5160 Localization of PTAFR 61 0.80 42.6 19.16 85.76
40 INT129037 Positive_regulation of TLX1NB 2 0.41 1.37 0.37 83.96
41 INT186742 Negative_regulation of Gene_expression of Ccl11 3 0.50 1.65 0.69 82.56
42 INT113100 Negative_regulation of Ccl11 4 0.58 4.38 0.95 82.00
43 INT14575 Positive_regulation of Ppt1 60 0.70 9.97 27.4 81.92
44 INT2649 Regulation of Calca 433 0.62 146.05 330.95 81.12
45 INT22239 Negative_regulation of TAC1 52 0.57 12.96 31.41 79.76
46 INT5008 Localization of Calca 204 0.81 80.35 125.16 79.52
47 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42 78.72
48 INT8794 Negative_regulation of Ppt1 35 0.57 6.44 14.52 75.12
49 INT54986 Negative_regulation of Positive_regulation of Calca 2 0.43 0.93 2.02 75.00
50 INT6993 Negative_regulation of Mpo 72 0.59 61.83 19.51 75.00
51 INT58226 Negative_regulation of Gene_expression of Il1b 24 0.57 18.09 12.68 75.00
52 INT108263 Negative_regulation of Gene_expression of Mpo 12 0.52 12.89 2.22 75.00
53 INT57692 Positive_regulation of Gene_expression of Il1b 50 0.67 43.54 28.29 75.00
54 INT124606 Positive_regulation of Gene_expression of Mpo 14 0.49 12.66 3.24 75.00
55 INT61519 Gene_expression of Mpo 112 0.78 89.29 18.22 75.00
56 INT15769 Gene_expression of Il1b 146 0.78 114.51 75.35 75.00
57 INT27887 Positive_regulation of Bhr1 2 0.39 0.74 0.09 75.00
58 INT26514 Regulation of Gene_expression of Mme 2 0.41 1.18 2.27 70.00
59 INT5780 Regulation of Gene_expression of Calca 90 0.62 59.52 85.03 70.00
60 INT186731 Positive_regulation of Ccl11 10 0.45 10.09 2.44 69.36
61 INT3300 Positive_regulation of Gene_expression of Calca 179 0.70 77.76 144.2 68.08
62 INT7134 Localization of KNG1 127 0.79 65.73 67.97 67.28
63 INT11480 Positive_regulation of Localization of KNG1 15 0.30 6.39 5.5 67.28
64 INT219695 Positive_regulation of Gene_expression of COPD 24 0.40 33.04 3.42 65.36
65 INT147792 Gene_expression of COPD 230 0.70 287.13 24.1 65.08
66 INT11292 Gene_expression of Mme 77 0.78 20.98 35.85 62.64
67 INT11042 Localization of Tbxa2r 26 0.76 10.15 7.24 60.56
68 INT725 Negative_regulation of IgG 62 0.41 37.21 8.16 57.36
69 INT115921 Positive_regulation of AHR 22 0.49 12.03 3.53 55.20
70 INT104935 Localization of AHR 6 0.74 2.54 0.53 55.20
71 INT125312 Positive_regulation of COPD 134 0.59 162.55 20.27 54.72
72 INT186738 Positive_regulation of Gene_expression of Ccl11 14 0.67 8.55 1.45 54.08
73 INT289306 Positive_regulation of Serpinb1b 6 0.41 2.83 0.48 49.32
74 INT4887 Gene_expression of Tac4 70 0.77 11.66 40.97 45.64
75 INT4895 Positive_regulation of Gene_expression of Tac4 16 0.69 2.46 11.51 45.64
76 INT4890 Gene_expression of Ppt1 51 0.77 8.93 21.83 25.00
77 INT4888 Positive_regulation of Gene_expression of Ppt1 9 0.54 2.78 5.83 25.00
78 INT60016 Negative_regulation of Il2rb 2 0.02 2.26 0.08 12.56
79 INT21532 Negative_regulation of Gene_expression of Il2 47 0.59 20.43 16.96 11.84
80 INT11807 Gene_expression of Il2 266 0.78 112 64.97 7.76
81 INT60436 Negative_regulation of COPD 76 0.37 84.22 9.08 5.24
82 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
83 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
84 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 5.00
85 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57 5.00
86 INT7180 Negative_regulation of Trib3 180 0.51 68.48 88.01 5.00
87 INT5056 Gene_expression of IFNG 216 0.78 137.52 74.57 5.00
88 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 5.00
89 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 5.00
90 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 5.00
91 INT5781 Gene_expression of Edn1 190 0.78 99.1 46 5.00
92 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
93 INT11939 Negative_regulation of Il6 138 0.59 87.46 41.24 5.00
94 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 5.00
95 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 5.00
96 INT73498 Gene_expression of IL13 117 0.44 83.85 32.26 5.00
97 INT56809 Binding of Tlr4 184 0.48 106.02 31.18 5.00
98 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 5.00
99 INT69157 Gene_expression of IL5 127 0.77 102.58 26.81 5.00
100 INT10836 Negative_regulation of IL8 95 0.59 52.59 24.71 5.00
101 INT8775 Binding of IGHE 167 0.48 102.61 23.54 5.00
102 INT78057 Localization of Tlr4 140 0.77 67.75 21.72 5.00
103 INT11804 Positive_regulation of Gene_expression of Il2 70 0.70 33 21.63 5.00
104 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 5.00
105 INT11803 Positive_regulation of Il2 62 0.70 31.44 18.93 5.00
106 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9 5.00
107 INT20622 Gene_expression of LDHA 107 0.76 77.97 16.3 5.00
108 INT9220 Gene_expression of Ighg1 125 0.77 85.74 15.92 5.00
109 INT43906 Regulation of Tlr4 71 0.53 35.18 15.49 5.00
110 INT20381 Localization of Il2 71 0.77 34.23 13.03 5.00
111 INT10870 Regulation of IgG 67 0.59 43.27 12.74 5.00
112 INT22030 Negative_regulation of Cysltr1 31 0.39 21.83 12.49 5.00
113 INT541 Positive_regulation of MBP 31 0.67 28.56 12.24 5.00
114 INT49266 Positive_regulation of Arigg4 37 0.47 53.79 11.2 5.00
115 INT94859 Negative_regulation of Pde5a 67 0.43 33.66 10.28 5.00
116 INT35164 Negative_regulation of IGHE 96 0.58 76.3 9.74 5.00
117 INT17741 Gene_expression of MBP 67 0.78 23.67 9.65 5.00
118 INT3988 Positive_regulation of Gene_expression of IGHE 98 0.68 91.46 9.61 5.00
119 INT61264 Regulation of Jun 36 0.61 18.42 8.71 5.00
120 INT20205 Binding of IgG 108 0.46 66.68 8.57 5.00
121 INT166881 Positive_regulation of Ccr1 31 0.69 18.14 7.9 5.00
122 INT71308 Gene_expression of CCL11 33 0.76 25.66 7.83 5.00
123 INT69160 Positive_regulation of IL5 41 0.65 36.04 7.75 5.00
124 INT46221 Positive_regulation of Gene_expression of IgG 46 0.53 33.66 7.7 5.00
125 INT10104 Negative_regulation of Edn1 43 0.59 15.63 7.2 5.00
126 INT14637 Negative_regulation of MBP 19 0.43 7.06 7.18 5.00
127 INT132822 Localization of IL13 26 0.67 22.85 6.66 5.00
128 INT73499 Positive_regulation of IL13 23 0.39 20.03 6.53 5.00
129 INT25385 Positive_regulation of Localization of Il2 17 0.45 9.53 6.45 5.00
130 INT157622 Positive_regulation of Localization of Tlr4 34 0.48 22.63 5.09 5.00
131 INT68244 Positive_regulation of Ighg1 60 0.61 48.86 5.01 5.00
132 INT89590 Negative_regulation of Gene_expression of Ccl5 8 0.36 3.97 4.67 5.00
133 INT73503 Positive_regulation of Gene_expression of IL13 16 0.37 14.6 4.23 5.00
134 INT9223 Localization of Ighg1 22 0.78 11.03 3.67 5.00
135 INT123564 Negative_regulation of Rock2 13 0.59 9.61 3.58 5.00
136 INT536 Binding of MBP 17 0.48 6.52 3.56 5.00
137 INT85130 Regulation of IL5 14 0.27 8.37 3.55 5.00
138 INT28528 Gene_expression of MSMB 25 0.65 7.66 3.49 5.00
139 INT84020 Positive_regulation of RNASE3 17 0.47 11.92 2.92 5.00
140 INT11815 Regulation of Il2 16 0.59 4.81 2.83 5.00
141 INT152434 Localization of CCL11 6 0.78 9.47 2.68 5.00
142 INT173504 Positive_regulation of Gene_expression of Ighg1 16 0.47 7.2 2.36 5.00
143 INT181361 Localization of Ccl11 5 0.54 3.67 2.16 5.00
144 INT14 Regulation of LDHA 22 0.57 15.26 2.14 5.00
145 INT179256 Positive_regulation of Localization of IL13 7 0.42 7.04 2.14 5.00
146 INT47626 Negative_regulation of Serpinb1b 4 0.37 3.79 2.13 5.00
147 INT68243 Regulation of Gene_expression of IgG 10 0.44 4.93 2.04 5.00
148 INT40104 Binding of Cysltr1 11 0.38 4.56 1.95 5.00
149 INT101148 Gene_expression of UCHL1 20 0.70 9.61 1.8 5.00
150 INT14092 Gene_expression of Serpinb1b 3 0.40 2.26 1.77 5.00
151 INT134197 Regulation of AHR 11 0.44 4.82 1.76 5.00
152 INT191862 Phosphorylation of Tlr4 17 0.79 6.89 1.74 5.00
153 INT100586 Localization of Il2rb 6 0.15 3.18 1.64 5.00
154 INT107641 Negative_regulation of Ighg1 19 0.39 11.44 1.54 5.00
155 INT24768 Negative_regulation of Gene_expression of Edn1 10 0.43 2.85 1.48 5.00
156 INT19483 Positive_regulation of Ppcs 3 0.37 14.1 1.36 5.00
157 INT18934 Gene_expression of GER 16 0.66 14.71 1.29 5.00
158 INT22403 Regulation of MSMB 10 0.39 2.5 1.28 5.00
159 INT207134 Positive_regulation of tryptase 11 0.47 11.16 1.21 5.00
160 INT208247 Negative_regulation of BDP1 1 0.01 0.99 1.02 5.00
161 INT208244 Regulation of Gene_expression of Ccl5 1 0.26 1.92 1.01 5.00
162 INT46169 Transcription of IgG 14 0.67 7.71 1.01 5.00
163 INT17151 Positive_regulation of Abpa 2 0.05 2.42 0.95 5.00
164 INT208243 Positive_regulation of Phosphorylation of Tlr4 5 0.31 3.74 0.86 5.00
165 INT138459 Gene_expression of MN1 2 0.60 0.92 0.85 5.00
166 INT32835 Negative_regulation of Pde3a 5 0.10 3.65 0.82 5.00
167 INT119102 Gene_expression of PDGFRA 13 0.75 11.99 0.81 5.00
168 INT118254 Negative_regulation of Ppcs 4 0.39 2.49 0.79 5.00
169 INT34489 Localization of CAPRIN1 4 0.70 1.2 0.78 5.00
170 INT113102 Transcription of Ccl11 4 0.52 2.48 0.77 5.00
171 INT274193 Negative_regulation of PES1 7 0.57 3.25 0.77 5.00
172 INT186739 Regulation of Ccl11 4 0.39 1.99 0.75 5.00
173 INT155704 Positive_regulation of MITF 10 0.45 7.51 0.7 5.00
174 INT64096 Negative_regulation of AHR 5 0.37 1.2 0.58 5.00
175 INT127273 Gene_expression of AMH 24 0.78 9.53 0.47 5.00
176 INT294416 Binding of Serpinb1b 1 0.05 0.89 0.46 5.00
177 INT9024 Negative_regulation of CAPRIN1 2 0.03 0.73 0.39 5.00
178 INT145801 Negative_regulation of Binding of Cysltr1 2 0.39 1.89 0.35 5.00
179 INT20629 Negative_regulation of Gene_expression of LDHA 4 0.41 1.78 0.34 5.00
180 INT141617 Regulation of Cysltr1 2 0.10 1.33 0.26 5.00
181 INT211181 Protein_catabolism of IGHE 1 0.07 1.28 0.25 5.00
182 INT214883 Binding of Atcay 2 0.10 1.1 0.22 5.00
183 INT254040 Regulation of FGF9 2 0.57 1.04 0.21 5.00
184 INT288535 Positive_regulation of Localization of Ccl11 1 0.32 1.19 0.21 5.00
185 INT216361 Negative_regulation of Gene_expression of MBP 3 0.43 0.9 0.19 5.00
186 INT238695 Binding of POLK 1 0.03 0 0.16 5.00
187 INT238696 Positive_regulation of Binding of POLK 1 0.05 0 0.16 5.00
188 INT108463 Binding of Ppcs 6 0.37 3.16 0.15 5.00
189 INT238679 Negative_regulation of Localization of Ighg1 2 0.39 0.61 0.15 5.00
190 INT113434 Negative_regulation of Gene_expression of UCHL1 4 0.53 1.34 0.12 5.00
191 INT119103 Gene_expression of FIP1L1 2 0.49 2.95 0.11 5.00
192 INT287199 Gene_expression of OCIAD1 2 0.04 0.34 0.11 5.00
193 INT179176 Negative_regulation of Asl 1 0.30 0.79 0.1 5.00
194 INT274191 Gene_expression of Ppcs 1 0.04 1.44 0.09 5.00
195 INT179175 Positive_regulation of Asl 1 0.38 0.39 0.09 5.00
196 INT113431 Negative_regulation of UCHL1 2 0.39 0.62 0.08 5.00
197 INT270687 Negative_regulation of Regulation of IL5 2 0.25 0.91 0.07 5.00
198 INT274190 Positive_regulation of Binding of Ppcs 1 0.03 0.54 0.04 5.00
199 INT302991 Localization of OCIAD1 1 0.05 0.08 0.04 5.00
200 INT302994 Regulation of Negative_regulation of CAPRIN1 1 0.02 0.74 0.03 5.00
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