D:Bronchial Hyperreactivity

Disease Term Synonyms Bronchial Hyperreactivities, Hyperreactivities Bronchial, HYPERREACTIVITY BRONCHIAL Documents 86 Hot Single Events 44 Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Bronchial Hyperreactivity. They are ordered first by their relevance to Bronchial Hyperreactivity and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Interaction String	Documents	TM Confidence	Disease Relevance	Overall Pain Relevance	Term Relevance
1	INT288537	Binding of Ccr3 and Ccl11	1	0.17	2.92	0.35	89.36
2	INT141979	Calca Negative_regulation of Gene_expression of Il1b	1	0.40	0.62	1.13	75.00
3	INT302985	HIVEP1 Positive_regulation of Positive_regulation of AHR	1	0.06	0.5	0.06	59.28
4	INT302984	MBP Positive_regulation of AHR	1	0.31	0.3	0.06	5.00
5	INT288538	Il2 Positive_regulation of Gene_expression of Bcl2	1	0.04	1.96	0.03	5.00
6	INT214886	Binding of Atcay and FIP1L1	1	0.08	4.06	0	5.00
7	INT214885	Binding of PDGFRA and Atcay	1	0.08	4.05	0	5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Bronchial Hyperreactivity. They are ordered first by their pain relevance and then by number of times they were reported in Bronchial Hyperreactivity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Event String	Documents	TM Confidence	Disease Relevance	Overall Pain Relevance	Term Relevance
1	INT15674	Positive_regulation of Gene_expression of Tac1	17	0.68	4.97	6.56	99.20
2	INT5061	Negative_regulation of Mme	306	0.59	51.97	136.9	99.08
3	INT5050	Regulation of Localization of Calca	149	0.62	41.25	148.57	99.00
4	INT11773	Gene_expression of Tac1	56	0.77	10	25.72	98.88
5	INT4758	Positive_regulation of Localization of Calca	557	0.70	138.55	411.04	98.74
6	INT3151	Localization of MBP	27	0.80	7.58	2.28	98.72
7	INT113101	Gene_expression of Ccl11	41	0.76	22.36	5.47	98.56
8	INT89294	Gene_expression of Ccr3	53	0.68	43.9	12.62	98.56
9	INT186735	Regulation of Gene_expression of Ccl11	4	0.40	2.07	0.64	98.56
10	INT189475	Regulation of Gene_expression of Ccr3	4	0.32	3.17	0.54	98.56
11	INT1912	Gene_expression of Calca	1152	0.78	453.25	739.84	98.54
12	INT2542	Localization of Calca	2008	0.81	518.3	1408.65	98.24
13	INT15166	Positive_regulation of Mme	40	0.70	13.01	16.24	98.08
14	INT53577	Negative_regulation of Localization of TNF	110	0.59	59.28	35.23	97.76
15	INT6483	Gene_expression of TNF	3152	0.78	2515.62	929.82	97.72
16	INT6852	Localization of TNF	883	0.81	705.95	270.84	97.20
17	INT13897	Localization of Sst	65	0.81	14.91	32.24	96.32
18	INT4509	Gene_expression of IgG	426	0.76	293.69	56.64	94.88
19	INT244226	Binding of Ccl11	4	0.25	1.81	0.65	94.36
20	INT5235	Negative_regulation of TNF	924	0.59	772.91	331.98	93.72
21	INT302990	Protein_catabolism of MBP	5	0.88	3.75	1.42	93.24
22	INT103061	Positive_regulation of Gene_expression of Ccl5	4	0.35	1.67	1.9	93.08
23	INT89594	Gene_expression of Ccl5	44	0.54	24.08	18.62	92.76
24	INT147413	Regulation of Sstr4	1	0.41	0.78	0.58	92.08
25	INT87687	Positive_regulation of Trpv1	409	0.70	210.24	257.59	91.32
26	INT22000	Positive_regulation of Sst	25	0.70	14.82	13.6	91.32
27	INT2543	Positive_regulation of Calca	787	0.70	331.13	592.08	90.88
28	INT51151	Positive_regulation of Regulation of Calca	8	0.50	1.77	3.08	90.88
29	INT28265	Positive_regulation of Calca	62	0.70	29.1	41.17	88.56
30	INT5010	Gene_expression of Calca	197	0.78	85.76	118.75	88.56
31	INT114434	Gene_expression of Calcrl	10	0.78	5.81	1.83	88.56
32	INT141977	Positive_regulation of Calcrl	2	0.70	0.93	0.75	88.56
33	INT5972	Gene_expression of IL1B	948	0.78	510.91	263.97	87.92
34	INT9233	Negative_regulation of Gene_expression of IL1B	114	0.59	56.99	41.82	87.92
35	INT2540	Negative_regulation of Calca	538	0.59	172.11	384.38	87.76
36	INT9235	Negative_regulation of Gene_expression of TNF	346	0.59	252.98	118.61	87.44
37	INT25363	Negative_regulation of Trpv1	144	0.59	64.78	75.7	87.40
38	INT110365	Negative_regulation of Positive_regulation of Mme	1	0.39	0.09	0.32	86.72
39	INT5160	Localization of PTAFR	61	0.80	42.6	19.16	85.76
40	INT129037	Positive_regulation of TLX1NB	2	0.41	1.37	0.37	83.96
41	INT186742	Negative_regulation of Gene_expression of Ccl11	3	0.50	1.65	0.69	82.56
42	INT113100	Negative_regulation of Ccl11	4	0.58	4.38	0.95	82.00
43	INT14575	Positive_regulation of Ppt1	60	0.70	9.97	27.4	81.92
44	INT2649	Regulation of Calca	433	0.62	146.05	330.95	81.12
45	INT22239	Negative_regulation of TAC1	52	0.57	12.96	31.41	79.76
46	INT5008	Localization of Calca	204	0.81	80.35	125.16	79.52
47	INT76660	Gene_expression of Trpv1	691	0.78	329.46	386.42	78.72
48	INT8794	Negative_regulation of Ppt1	35	0.57	6.44	14.52	75.12
49	INT54986	Negative_regulation of Positive_regulation of Calca	2	0.43	0.93	2.02	75.00
50	INT6993	Negative_regulation of Mpo	72	0.59	61.83	19.51	75.00
51	INT58226	Negative_regulation of Gene_expression of Il1b	24	0.57	18.09	12.68	75.00
52	INT108263	Negative_regulation of Gene_expression of Mpo	12	0.52	12.89	2.22	75.00
53	INT57692	Positive_regulation of Gene_expression of Il1b	50	0.67	43.54	28.29	75.00
54	INT124606	Positive_regulation of Gene_expression of Mpo	14	0.49	12.66	3.24	75.00
55	INT61519	Gene_expression of Mpo	112	0.78	89.29	18.22	75.00
56	INT15769	Gene_expression of Il1b	146	0.78	114.51	75.35	75.00
57	INT27887	Positive_regulation of Bhr1	2	0.39	0.74	0.09	75.00
58	INT26514	Regulation of Gene_expression of Mme	2	0.41	1.18	2.27	70.00
59	INT5780	Regulation of Gene_expression of Calca	90	0.62	59.52	85.03	70.00
60	INT186731	Positive_regulation of Ccl11	10	0.45	10.09	2.44	69.36
61	INT3300	Positive_regulation of Gene_expression of Calca	179	0.70	77.76	144.2	68.08
62	INT7134	Localization of KNG1	127	0.79	65.73	67.97	67.28
63	INT11480	Positive_regulation of Localization of KNG1	15	0.30	6.39	5.5	67.28
64	INT219695	Positive_regulation of Gene_expression of COPD	24	0.40	33.04	3.42	65.36
65	INT147792	Gene_expression of COPD	230	0.70	287.13	24.1	65.08
66	INT11292	Gene_expression of Mme	77	0.78	20.98	35.85	62.64
67	INT11042	Localization of Tbxa2r	26	0.76	10.15	7.24	60.56
68	INT725	Negative_regulation of IgG	62	0.41	37.21	8.16	57.36
69	INT115921	Positive_regulation of AHR	22	0.49	12.03	3.53	55.20
70	INT104935	Localization of AHR	6	0.74	2.54	0.53	55.20
71	INT125312	Positive_regulation of COPD	134	0.59	162.55	20.27	54.72
72	INT186738	Positive_regulation of Gene_expression of Ccl11	14	0.67	8.55	1.45	54.08
73	INT289306	Positive_regulation of Serpinb1b	6	0.41	2.83	0.48	49.32
74	INT4887	Gene_expression of Tac4	70	0.77	11.66	40.97	45.64
75	INT4895	Positive_regulation of Gene_expression of Tac4	16	0.69	2.46	11.51	45.64
76	INT4890	Gene_expression of Ppt1	51	0.77	8.93	21.83	25.00
77	INT4888	Positive_regulation of Gene_expression of Ppt1	9	0.54	2.78	5.83	25.00
78	INT60016	Negative_regulation of Il2rb	2	0.02	2.26	0.08	12.56
79	INT21532	Negative_regulation of Gene_expression of Il2	47	0.59	20.43	16.96	11.84
80	INT11807	Gene_expression of Il2	266	0.78	112	64.97	7.76
81	INT60436	Negative_regulation of COPD	76	0.37	84.22	9.08	5.24
82	INT9659	Gene_expression of Il6	991	0.78	715.11	265.57	5.00
83	INT10194	Positive_regulation of IL6	702	0.70	600.62	183.38	5.00
84	INT15516	Gene_expression of Crp	711	0.77	615.33	173.09	5.00
85	INT7533	Gene_expression of Tlr4	720	0.78	343.22	121.57	5.00
86	INT7180	Negative_regulation of Trib3	180	0.51	68.48	88.01	5.00
87	INT5056	Gene_expression of IFNG	216	0.78	137.52	74.57	5.00
88	INT4960	Positive_regulation of CSF2	285	0.70	256.73	65.73	5.00
89	INT3375	Gene_expression of IGHE	535	0.77	387.47	65.46	5.00
90	INT48901	Negative_regulation of IL6	186	0.57	136.33	57.87	5.00
91	INT5781	Gene_expression of Edn1	190	0.78	99.1	46	5.00
92	INT157666	Positive_regulation of GOPC	335	0.60	120.19	42.75	5.00
93	INT11939	Negative_regulation of Il6	138	0.59	87.46	41.24	5.00
94	INT3987	Positive_regulation of IGHE	316	0.70	283.2	40.16	5.00
95	INT77307	Gene_expression of Bcl2	399	0.77	319.77	38	5.00
96	INT73498	Gene_expression of IL13	117	0.44	83.85	32.26	5.00
97	INT56809	Binding of Tlr4	184	0.48	106.02	31.18	5.00
98	INT11554	Negative_regulation of CSF2	129	0.59	108.55	29.44	5.00
99	INT69157	Gene_expression of IL5	127	0.77	102.58	26.81	5.00
100	INT10836	Negative_regulation of IL8	95	0.59	52.59	24.71	5.00
101	INT8775	Binding of IGHE	167	0.48	102.61	23.54	5.00
102	INT78057	Localization of Tlr4	140	0.77	67.75	21.72	5.00
103	INT11804	Positive_regulation of Gene_expression of Il2	70	0.70	33	21.63	5.00
104	INT12265	Positive_regulation of IgG	168	0.63	104.89	19.76	5.00
105	INT11803	Positive_regulation of Il2	62	0.70	31.44	18.93	5.00
106	INT28951	Negative_regulation of IGF1	133	0.59	75.77	18.9	5.00
107	INT20622	Gene_expression of LDHA	107	0.76	77.97	16.3	5.00
108	INT9220	Gene_expression of Ighg1	125	0.77	85.74	15.92	5.00
109	INT43906	Regulation of Tlr4	71	0.53	35.18	15.49	5.00
110	INT20381	Localization of Il2	71	0.77	34.23	13.03	5.00
111	INT10870	Regulation of IgG	67	0.59	43.27	12.74	5.00
112	INT22030	Negative_regulation of Cysltr1	31	0.39	21.83	12.49	5.00
113	INT541	Positive_regulation of MBP	31	0.67	28.56	12.24	5.00
114	INT49266	Positive_regulation of Arigg4	37	0.47	53.79	11.2	5.00
115	INT94859	Negative_regulation of Pde5a	67	0.43	33.66	10.28	5.00
116	INT35164	Negative_regulation of IGHE	96	0.58	76.3	9.74	5.00
117	INT17741	Gene_expression of MBP	67	0.78	23.67	9.65	5.00
118	INT3988	Positive_regulation of Gene_expression of IGHE	98	0.68	91.46	9.61	5.00
119	INT61264	Regulation of Jun	36	0.61	18.42	8.71	5.00
120	INT20205	Binding of IgG	108	0.46	66.68	8.57	5.00
121	INT166881	Positive_regulation of Ccr1	31	0.69	18.14	7.9	5.00
122	INT71308	Gene_expression of CCL11	33	0.76	25.66	7.83	5.00
123	INT69160	Positive_regulation of IL5	41	0.65	36.04	7.75	5.00
124	INT46221	Positive_regulation of Gene_expression of IgG	46	0.53	33.66	7.7	5.00
125	INT10104	Negative_regulation of Edn1	43	0.59	15.63	7.2	5.00
126	INT14637	Negative_regulation of MBP	19	0.43	7.06	7.18	5.00
127	INT132822	Localization of IL13	26	0.67	22.85	6.66	5.00
128	INT73499	Positive_regulation of IL13	23	0.39	20.03	6.53	5.00
129	INT25385	Positive_regulation of Localization of Il2	17	0.45	9.53	6.45	5.00
130	INT157622	Positive_regulation of Localization of Tlr4	34	0.48	22.63	5.09	5.00
131	INT68244	Positive_regulation of Ighg1	60	0.61	48.86	5.01	5.00
132	INT89590	Negative_regulation of Gene_expression of Ccl5	8	0.36	3.97	4.67	5.00
133	INT73503	Positive_regulation of Gene_expression of IL13	16	0.37	14.6	4.23	5.00
134	INT9223	Localization of Ighg1	22	0.78	11.03	3.67	5.00
135	INT123564	Negative_regulation of Rock2	13	0.59	9.61	3.58	5.00
136	INT536	Binding of MBP	17	0.48	6.52	3.56	5.00
137	INT85130	Regulation of IL5	14	0.27	8.37	3.55	5.00
138	INT28528	Gene_expression of MSMB	25	0.65	7.66	3.49	5.00
139	INT84020	Positive_regulation of RNASE3	17	0.47	11.92	2.92	5.00
140	INT11815	Regulation of Il2	16	0.59	4.81	2.83	5.00
141	INT152434	Localization of CCL11	6	0.78	9.47	2.68	5.00
142	INT173504	Positive_regulation of Gene_expression of Ighg1	16	0.47	7.2	2.36	5.00
143	INT181361	Localization of Ccl11	5	0.54	3.67	2.16	5.00
144	INT14	Regulation of LDHA	22	0.57	15.26	2.14	5.00
145	INT179256	Positive_regulation of Localization of IL13	7	0.42	7.04	2.14	5.00
146	INT47626	Negative_regulation of Serpinb1b	4	0.37	3.79	2.13	5.00
147	INT68243	Regulation of Gene_expression of IgG	10	0.44	4.93	2.04	5.00
148	INT40104	Binding of Cysltr1	11	0.38	4.56	1.95	5.00
149	INT101148	Gene_expression of UCHL1	20	0.70	9.61	1.8	5.00
150	INT14092	Gene_expression of Serpinb1b	3	0.40	2.26	1.77	5.00
151	INT134197	Regulation of AHR	11	0.44	4.82	1.76	5.00
152	INT191862	Phosphorylation of Tlr4	17	0.79	6.89	1.74	5.00
153	INT100586	Localization of Il2rb	6	0.15	3.18	1.64	5.00
154	INT107641	Negative_regulation of Ighg1	19	0.39	11.44	1.54	5.00
155	INT24768	Negative_regulation of Gene_expression of Edn1	10	0.43	2.85	1.48	5.00
156	INT19483	Positive_regulation of Ppcs	3	0.37	14.1	1.36	5.00
157	INT18934	Gene_expression of GER	16	0.66	14.71	1.29	5.00
158	INT22403	Regulation of MSMB	10	0.39	2.5	1.28	5.00
159	INT207134	Positive_regulation of tryptase	11	0.47	11.16	1.21	5.00
160	INT208247	Negative_regulation of BDP1	1	0.01	0.99	1.02	5.00
161	INT208244	Regulation of Gene_expression of Ccl5	1	0.26	1.92	1.01	5.00
162	INT46169	Transcription of IgG	14	0.67	7.71	1.01	5.00
163	INT17151	Positive_regulation of Abpa	2	0.05	2.42	0.95	5.00
164	INT208243	Positive_regulation of Phosphorylation of Tlr4	5	0.31	3.74	0.86	5.00
165	INT138459	Gene_expression of MN1	2	0.60	0.92	0.85	5.00
166	INT32835	Negative_regulation of Pde3a	5	0.10	3.65	0.82	5.00
167	INT119102	Gene_expression of PDGFRA	13	0.75	11.99	0.81	5.00
168	INT118254	Negative_regulation of Ppcs	4	0.39	2.49	0.79	5.00
169	INT34489	Localization of CAPRIN1	4	0.70	1.2	0.78	5.00
170	INT113102	Transcription of Ccl11	4	0.52	2.48	0.77	5.00
171	INT274193	Negative_regulation of PES1	7	0.57	3.25	0.77	5.00
172	INT186739	Regulation of Ccl11	4	0.39	1.99	0.75	5.00
173	INT155704	Positive_regulation of MITF	10	0.45	7.51	0.7	5.00
174	INT64096	Negative_regulation of AHR	5	0.37	1.2	0.58	5.00
175	INT127273	Gene_expression of AMH	24	0.78	9.53	0.47	5.00
176	INT294416	Binding of Serpinb1b	1	0.05	0.89	0.46	5.00
177	INT9024	Negative_regulation of CAPRIN1	2	0.03	0.73	0.39	5.00
178	INT145801	Negative_regulation of Binding of Cysltr1	2	0.39	1.89	0.35	5.00
179	INT20629	Negative_regulation of Gene_expression of LDHA	4	0.41	1.78	0.34	5.00
180	INT141617	Regulation of Cysltr1	2	0.10	1.33	0.26	5.00
181	INT211181	Protein_catabolism of IGHE	1	0.07	1.28	0.25	5.00
182	INT214883	Binding of Atcay	2	0.10	1.1	0.22	5.00
183	INT254040	Regulation of FGF9	2	0.57	1.04	0.21	5.00
184	INT288535	Positive_regulation of Localization of Ccl11	1	0.32	1.19	0.21	5.00
185	INT216361	Negative_regulation of Gene_expression of MBP	3	0.43	0.9	0.19	5.00
186	INT238695	Binding of POLK	1	0.03	0	0.16	5.00
187	INT238696	Positive_regulation of Binding of POLK	1	0.05	0	0.16	5.00
188	INT108463	Binding of Ppcs	6	0.37	3.16	0.15	5.00
189	INT238679	Negative_regulation of Localization of Ighg1	2	0.39	0.61	0.15	5.00
190	INT113434	Negative_regulation of Gene_expression of UCHL1	4	0.53	1.34	0.12	5.00
191	INT119103	Gene_expression of FIP1L1	2	0.49	2.95	0.11	5.00
192	INT287199	Gene_expression of OCIAD1	2	0.04	0.34	0.11	5.00
193	INT179176	Negative_regulation of Asl	1	0.30	0.79	0.1	5.00
194	INT274191	Gene_expression of Ppcs	1	0.04	1.44	0.09	5.00
195	INT179175	Positive_regulation of Asl	1	0.38	0.39	0.09	5.00
196	INT113431	Negative_regulation of UCHL1	2	0.39	0.62	0.08	5.00
197	INT270687	Negative_regulation of Regulation of IL5	2	0.25	0.91	0.07	5.00
198	INT274190	Positive_regulation of Binding of Ppcs	1	0.03	0.54	0.04	5.00
199	INT302991	Localization of OCIAD1	1	0.05	0.08	0.04	5.00
200	INT302994	Regulation of Negative_regulation of CAPRIN1	1	0.02	0.74	0.03	5.00