D:Bronchiectasis

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Disease Term
Synonyms ACQUIRED BRONCHIECTASIS, Bronchiectases, Bronchiectasis Disorder, Congenital Bronchiectasis
Documents 258
Hot Single Events 108
Hot Interactions 5

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Bronchiectasis. They are ordered first by their relevance to Bronchiectasis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT284570 Binding of Avp and Il6 1 0.04 2.17 0.13 97.52
2 INT202422 IL8 Positive_regulation of Localization of ELANE 1 0.02 0.91 0.24 95.68
3 INT322208 HRCT1 Positive_regulation of PDX1 1 0.01 1.31 0.34 93.64
4 INT318387 Binding of Slc40a1 and Hrct1 1 0.02 0.88 0.08 92.04
5 INT243044 Mmp8 Regulation of Mmp9 1 0.05 1.45 0.91 80.80
6 INT230437 Binding of PDX1 and HRCT1 1 0.04 2.45 0.43 34.68
7 INT149117 Binding of CD80 and CTLA4 31 0.52 12.7 7.73 5.00
8 INT155484 Binding of CD86 and CTLA4 15 0.52 8.85 6.09 5.00
9 INT243043 Binding of Mmp9 and Timp1 1 0.05 0.25 1.86 5.00
10 INT187290 Binding of HEY1 and Gtf3a 1 0.00 6.18 0.83 5.00
11 INT186713 IK Positive_regulation of Gene_expression of NOS1 1 0.00 0.55 0.49 5.00
12 INT186711 IK Positive_regulation of Localization of IL8 1 0.00 0.39 0.44 5.00
13 INT248146 PLA2G6 Negative_regulation of Phosphorylation of PLA2G4A 1 0.07 0.72 0.4 5.00
14 INT230438 Binding of PDX1 and HAUS7 1 0.02 2.29 0.35 5.00
15 INT352547 Binding of CFTR and DMD 1 0.01 1.42 0.35 5.00
16 INT190826 ELANE Positive_regulation of Localization of MUC1 1 0.07 0 0.29 5.00
17 INT346957 HDAC9 Positive_regulation of Gene_expression of GSR 1 0.03 1.28 0.27 5.00
18 INT190827 KCNA1 Regulation of Localization of MUC1 1 0.05 0.08 0.22 5.00
19 INT310939 Binding of ELANE and COPD 1 0.08 1.51 0.2 5.00
20 INT310938 Binding of ELANE and HRCT1 1 0.02 1.5 0.2 5.00
21 INT310937 Binding of CD8A and COPD 1 0.16 1.21 0.16 5.00
22 INT248147 PLAT Positive_regulation of Gene_expression of CPOX 1 0.00 0.51 0.15 5.00
23 INT194383 Il13 Positive_regulation of Gene_expression of Il4 1 0.00 1.75 0.13 5.00
24 INT352555 DKK1 Positive_regulation of Wnt2 1 0.01 0.25 0.1 5.00
25 INT194385 Il13 Positive_regulation of Gene_expression of IGHE 1 0.00 0.8 0.09 5.00
26 INT322207 CCL18 Regulation of Gene_expression of COL7A1 1 0.07 0.88 0.09 5.00
27 INT186729 Csf2 Positive_regulation of PPARA 1 0.06 1.04 0.08 5.00
28 INT186712 INCENP Positive_regulation of PPARA 1 0.01 1.05 0.08 5.00
29 INT322206 CCL18 Positive_regulation of Gene_expression of COL7A1 1 0.05 0.28 0.05 5.00
30 INT310727 Binding of DKC1 and TERT 1 0.23 0.91 0.05 5.00
31 INT269759 PTH Positive_regulation of DMD 2 0.06 0.37 0.03 5.00
32 INT352392 Binding of ENOSF1 and Recql4 1 0.02 6.62 0 5.00
33 INT304618 Binding of Lta and Omt2a 1 0.01 0.19 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Bronchiectasis. They are ordered first by their pain relevance and then by number of times they were reported in Bronchiectasis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT147793 Localization of COPD 70 0.64 89.01 7.3 100.00
2 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 99.98
3 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 99.92
4 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53 99.92
5 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 99.58
6 INT168600 Binding of Mmp9 14 0.44 12.79 6.92 99.40
7 INT243030 Binding of Mmp8 1 0.10 2.4 1.82 99.40
8 INT95565 Positive_regulation of IL12A 47 0.56 33.96 10.16 99.36
9 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31 99.28
10 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44 99.28
11 INT147792 Gene_expression of COPD 230 0.70 287.13 24.1 99.10
12 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 99.04
13 INT36263 Positive_regulation of CEL 53 0.69 34.88 12.87 99.04
14 INT4465 Gene_expression of CEL 116 0.77 98.35 23.58 98.80
15 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 98.76
16 INT36287 Binding of CD4 96 0.47 58.93 11.88 98.64
17 INT202428 Positive_regulation of Binding of CD4 4 0.37 2.11 0.68 98.64
18 INT158295 Transcription of CD8A 11 0.53 4.02 0.7 98.60
19 INT202426 Transcription of CD4 6 0.69 3.96 0.49 98.60
20 INT202427 Negative_regulation of Localization of CD4 2 0.32 3.1 0.56 98.60
21 INT17049 Localization of CD4 57 0.75 35.33 6.89 98.60
22 INT19856 Gene_expression of CD8A 240 0.75 147.86 26.39 98.52
23 INT477 Localization of Avp 813 0.81 131.58 300.4 98.16
24 INT19511 Localization of Il6 212 0.81 118.17 67.67 98.16
25 INT151099 Negative_regulation of CFTR 12 0.59 10.28 3.79 98.12
26 INT244343 Localization of NTM 16 0.73 14.26 0.26 97.92
27 INT202424 Gene_expression of HRCT1 3 0.07 3.47 0.36 97.80
28 INT894 Binding of Avp 84 0.48 29.16 29.63 97.52
29 INT150395 Binding of MEFV 55 0.44 31.18 3.42 97.40
30 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 97.00
31 INT63839 Binding of CRS 31 0.41 34.05 4.7 96.72
32 INT84307 Binding of Cftr 31 0.47 26.19 12.8 96.36
33 INT49235 Localization of DNASE1 7 0.81 1.69 1.04 96.36
34 INT108328 Negative_regulation of Gene_expression of CEL 6 0.57 2.56 0.63 96.28
35 INT51474 Binding of Il6 55 0.48 44.99 20.52 96.24
36 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 96.16
37 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 96.16
38 INT17805 Regulation of Localization of ELANE 7 0.59 1.88 1.08 95.68
39 INT2609 Localization of ELANE 111 0.81 50.22 26.63 95.68
40 INT52350 Gene_expression of CD14 184 0.75 71.37 33.13 95.68
41 INT97138 Positive_regulation of Gene_expression of CD14 17 0.48 9.07 3.35 95.68
42 INT27551 Gene_expression of SERPINH1 45 0.62 42.87 9.04 95.32
43 INT2389 Regulation of PTGS1 86 0.61 31.23 28.95 94.76
44 INT133028 Gene_expression of TLR2 209 0.73 131.92 36.17 94.48
45 INT133030 Positive_regulation of Gene_expression of TLR2 53 0.65 38.15 10.65 94.48
46 INT56985 Gene_expression of MEFV 56 0.71 46.71 9.47 94.44
47 INT18995 Binding of CEL 23 0.47 14.46 4.5 94.40
48 INT244342 Gene_expression of NTM 1 0.58 0.95 0 94.36
49 INT59862 Phosphorylation of CEL 2 0.70 0.53 0.3 93.84
50 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 93.80
51 INT115384 Positive_regulation of Mmp9 121 0.68 94.74 43.02 93.76
52 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 93.76
53 INT96937 Gene_expression of Mmp9 191 0.75 150.3 56.01 93.76
54 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 93.72
55 INT89113 Regulation of Cftr 11 0.62 6.83 4.01 93.36
56 INT83911 Negative_regulation of Gene_expression of SERPINA1 3 0.43 5.2 2.07 93.20
57 INT220861 Positive_regulation of Mmp8 14 0.50 12.21 4.6 92.96
58 INT184257 Positive_regulation of Gene_expression of Mmp8 7 0.49 6.32 2.74 92.96
59 INT155780 Gene_expression of Mmp8 19 0.77 15.85 6.33 92.96
60 INT96068 Positive_regulation of Timp1 30 0.58 23.94 8.17 92.80
61 INT91764 Positive_regulation of Gene_expression of PLA2G4A 8 0.69 5.43 1.52 92.76
62 INT64864 Gene_expression of PLA2G4A 18 0.77 10.45 4.09 92.76
63 INT28238 Positive_regulation of Hrct1 5 0.38 3.66 0.5 92.76
64 INT10049 Negative_regulation of SERPINA1 56 0.59 44.52 9.93 92.64
65 INT4391 Gene_expression of SERPINA1 47 0.78 41.43 9.7 92.64
66 INT68032 Regulation of Hrct1 3 0.36 2.78 0.67 92.52
67 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 91.36
68 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 91.20
69 INT310726 Localization of Terc 1 0.24 0.27 0 90.80
70 INT274377 Localization of TERT 3 0.70 0.78 0 90.80
71 INT7093 Negative_regulation of CYP2B6 146 0.58 37.3 48.39 90.72
72 INT9196 Gene_expression of PTGS1 215 0.77 96.99 60.5 90.44
73 INT202425 Negative_regulation of Transcription of CEL 1 0.03 0.49 0.21 90.36
74 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 90.32
75 INT153300 Negative_regulation of Gene_expression of CRP 48 0.58 39.97 7.58 90.28
76 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 90.04
77 INT76127 Transcription of CEL 5 0.71 2.02 0.7 89.96
78 INT139982 Positive_regulation of BACE2 6 0.42 4.33 1.48 89.68
79 INT149295 Regulation of NOTCH1 10 0.13 4.26 1.22 89.68
80 INT113606 Positive_regulation of Gene_expression of Mmp9 46 0.64 44 15.07 89.64
81 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 89.40
82 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 89.40
83 INT23245 Positive_regulation of Gene_expression of CEL 19 0.69 14.81 4.92 89.36
84 INT6852 Localization of TNF 883 0.81 705.95 270.84 89.16
85 INT302520 Negative_regulation of Gene_expression of Slc28a1 2 0.12 1.85 0.19 89.00
86 INT212624 Gene_expression of Slc28a1 9 0.53 3.47 0.44 88.64
87 INT9234 Negative_regulation of Gene_expression of IL6 171 0.59 101.61 53.15 88.40
88 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 88.20
89 INT77282 Positive_regulation of Cftr 23 0.69 21.8 9.65 87.16
90 INT47514 Localization of Avpr2 7 0.61 4.43 1.24 86.92
91 INT24326 Gene_expression of Ngf 346 0.78 218.67 184.71 85.68
92 INT7886 Regulation of Localization of Avp 146 0.62 14.53 72.99 85.64
93 INT48222 Positive_regulation of Localization of IL8 123 0.59 78.04 37.2 85.44
94 INT12082 Localization of IL6 365 0.81 241.78 105.78 85.00
95 INT12339 Localization of IL8 437 0.81 251.87 117.39 84.64
96 INT138802 Gene_expression of CFTR 36 0.70 18.8 7.02 84.56
97 INT19330 Binding of HLA-A 99 0.48 76.26 22.85 84.40
98 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 83.28
99 INT112830 Binding of Tg(EGFR)5Jlj 3 0.03 2.39 1.07 83.20
100 INT75832 Positive_regulation of Positive_regulation of IL8 30 0.70 20.77 6.05 82.56
101 INT190833 Regulation of KCNA1 8 0.53 6.61 4.66 82.36
102 INT16969 Negative_regulation of CRS 28 0.37 14.77 3.35 82.16
103 INT5653 Positive_regulation of ELANE 136 0.70 72.78 27.94 81.84
104 INT22823 Positive_regulation of Positive_regulation of ELANE 12 0.45 6.89 3.35 81.84
105 INT125312 Positive_regulation of COPD 134 0.59 162.55 20.27 81.48
106 INT170528 Negative_regulation of Gene_expression of CD4 25 0.41 17.98 3.6 80.44
107 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 80.28
108 INT330760 Positive_regulation of Gene_expression of LETMD1 1 0.04 1.46 0.38 80.12
109 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 79.76
110 INT61171 Gene_expression of S100A8 92 0.76 57.74 9.98 78.72
111 INT94042 Positive_regulation of Gene_expression of S100A8 15 0.67 13.52 2.44 78.72
112 INT166710 Positive_regulation of Gene_expression of CFTR 9 0.46 3.72 2.03 78.72
113 INT330759 Gene_expression of LETMD1 1 0.04 1.39 0.35 78.72
114 INT2451 Positive_regulation of Avp 355 0.70 102.66 147.69 78.56
115 INT61624 Positive_regulation of Gene_expression of IL12A 50 0.56 33.07 13.07 78.16
116 INT61619 Gene_expression of IL12A 194 0.77 146.07 41.97 78.16
117 INT179686 Regulation of Gene_expression of COPD 10 0.34 14.1 1.52 78.16
118 INT73572 Positive_regulation of S100A8 10 0.67 6.6 1 77.84
119 INT16966 Positive_regulation of CRS 23 0.60 22.5 3.49 76.96
120 INT151102 Positive_regulation of CFTR 22 0.61 15.27 5.12 76.64
121 INT330761 Positive_regulation of LETMD1 1 0.03 1.36 0.34 76.64
122 INT108798 Negative_regulation of Positive_regulation of ALPP 9 0.25 4.26 1.46 76.24
123 INT45975 Positive_regulation of SAA1 17 0.67 19.7 4.15 73.72
124 INT171060 Gene_expression of PDX1 72 0.75 72.57 17.97 72.32
125 INT171059 Localization of PDX1 8 0.56 6.7 1.9 72.32
126 INT10835 Regulation of IL8 79 0.49 53.04 24.14 72.08
127 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 72.00
128 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 71.76
129 INT17151 Positive_regulation of Abpa 2 0.05 2.42 0.95 71.36
130 INT1429 Gene_expression of PDYN 308 0.78 61.33 175.65 71.20
131 INT25634 Binding of Mpo 21 0.48 14.78 4.39 70.96
132 INT5650 Gene_expression of Mpo 117 0.77 80.27 26.42 70.68
133 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 70.64
134 INT103842 Gene_expression of Cftr 53 0.78 59.59 21.82 70.28
135 INT100650 Gene_expression of Recql4 2 0.42 1.72 0.28 69.76
136 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 69.68
137 INT28872 Positive_regulation of CSRP1 49 0.70 47.23 11.7 67.96
138 INT60436 Negative_regulation of COPD 76 0.37 84.22 9.08 67.88
139 INT4931 Localization of IFNG 53 0.78 33.25 13.65 67.76
140 INT170757 Positive_regulation of Gene_expression of Cftr 3 0.51 11.41 4.75 66.32
141 INT24891 Gene_expression of SYP 55 0.75 45.76 7.53 65.60
142 INT169575 Regulation of H1FNT 3 0.07 3.41 0.74 64.96
143 INT50670 Gene_expression of CPOX 763 0.76 442.13 195.02 64.60
144 INT9994 Negative_regulation of Localization of C6orf25 3 0.09 1.54 0.13 63.84
145 INT101891 Negative_regulation of Cftr 25 0.58 24.09 9.55 63.52
146 INT55687 Localization of TIMP1 47 0.74 30.24 12.31 63.12
147 INT55690 Positive_regulation of Localization of TIMP1 8 0.50 4.77 3.28 63.12
148 INT9995 Localization of C6orf25 13 0.69 6.48 2.29 62.88
149 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 62.72
150 INT32165 Binding of CALM1 92 0.48 24.19 29.57 62.12
151 INT158099 Positive_regulation of Regulation of Hrct1 1 0.41 1.31 0.13 62.00
152 INT17511 Negative_regulation of PRTN3 19 0.41 12 3.3 60.52
153 INT2673 Negative_regulation of PROC 93 0.57 50.34 12.79 58.80
154 INT230441 Positive_regulation of HRCT1 1 0.05 0.74 0.12 58.00
155 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 57.92
156 INT5940 Negative_regulation of Avp 236 0.59 67.86 101.2 56.88
157 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 55.84
158 INT27933 Gene_expression of NCOR2 65 0.72 31.35 24.23 55.84
159 INT101517 Negative_regulation of PPARA 168 0.57 112.24 21.41 55.48
160 INT186174 Negative_regulation of Hrct1 1 0.02 1.29 0.28 55.12
161 INT59900 Binding of MATN3 13 0.42 17.19 3.59 54.00
162 INT719 Negative_regulation of SGCG 96 0.57 47.91 30.22 53.84
163 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 52.40
164 INT59465 Negative_regulation of ISYNA1 41 0.49 21.9 9.46 52.40
165 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 51.92
166 INT62041 Negative_regulation of Gene_expression of IGHE 37 0.58 37.86 5.27 51.52
167 INT4535 Localization of PROC 106 0.73 76.24 21.1 50.64
168 INT153668 Negative_regulation of Gene_expression of BTK 2 0.41 2.23 0.46 50.64
169 INT153674 Gene_expression of BTK 14 0.75 8.4 0.49 50.16
170 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 50.00
171 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59 48.20
172 INT15540 Positive_regulation of PDGFA 24 0.47 19.01 2.5 48.20
173 INT52264 Gene_expression of IK 180 0.77 90.87 51.87 48.00
174 INT187286 Binding of HEY1 17 0.32 31.21 4.52 47.52
175 INT62044 Binding of Lta 16 0.30 7.49 1.01 47.48
176 INT157252 Binding of Omt2a 3 0.32 1.83 0.2 47.48
177 INT22875 Regulation of CRS 16 0.39 14.33 2.69 46.64
178 INT230645 Binding of PLEC 3 0.47 0.8 0.12 44.92
179 INT70450 Binding of KRT5 6 0.47 5.72 0.08 44.92
180 INT192563 Gene_expression of HAT1 8 0.38 4.47 1.71 44.48
181 INT174851 Positive_regulation of COL5A2 46 0.54 12.73 5.48 43.60
182 INT24978 Binding of SFTPA1 22 0.47 15.09 7.76 42.80
183 INT243034 Positive_regulation of Rarb 1 0.04 4.07 2.52 42.48
184 INT130603 Binding of Timp1 9 0.35 8.52 3.04 41.88
185 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 41.80
186 INT192225 Gene_expression of HDAC9 35 0.58 32.82 6.36 40.96
187 INT216289 Positive_regulation of BTK 1 0.48 1.03 0 40.92
188 INT186727 Negative_regulation of Localization of PPARA 4 0.35 4.56 0.69 39.88
189 INT173159 Localization of PPARA 96 0.74 64.55 10.26 39.52
190 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67 39.00
191 INT73502 Positive_regulation of IL10 154 0.69 124.87 43.5 38.64
192 INT25152 Gene_expression of SAA1 37 0.75 53.56 8.07 38.36
193 INT192761 Positive_regulation of Gene_expression of SAA1 5 0.40 7.45 0.82 38.36
194 INT14184 Positive_regulation of CPB1 23 0.55 14.38 1.73 37.92
195 INT180392 Positive_regulation of SARS2 1 0.32 0.9 0 37.24
196 INT82354 Positive_regulation of PECAM1 25 0.34 22.93 4.69 36.84
197 INT155860 Positive_regulation of ENOSF1 5 0.19 3.15 0.95 36.56
198 INT155861 Negative_regulation of ENOSF1 3 0.42 3.29 0.63 36.56
199 INT99550 Regulation of FLNA 51 0.54 27.88 2.58 35.12
200 INT49802 Localization of MUC1 75 0.81 44.74 8.87 32.92
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