D:Bronchiolitis Obliterans

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Disease Term
Synonyms Bronchiolitides Exudative, Bronchiolitides Proliferative, BRONCHIOLITIS EXUDATIVE, BRONCHIOLITIS PROLIFERATIVE, Exudative Bronchiolitides, Exudative Bronchiolitis, Proliferative Bronchiolitides, Proliferative Bronchiolitis
Documents 53
Hot Single Events 19
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Bronchiolitis Obliterans. They are ordered first by their relevance to Bronchiolitis Obliterans and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT311012 SNRPB Positive_regulation of Gene_expression of ROS1 1 0.00 0.27 0 98.92
2 INT243044 Mmp8 Regulation of Mmp9 1 0.05 1.45 0.91 93.56
3 INT311009 Binding of LCN2 and SNRPB 1 0.01 0.35 0.1 76.16
4 INT311011 SNRPB Positive_regulation of Gene_expression of LCN2 1 0.02 0 0 50.00
5 INT243043 Binding of Mmp9 and Timp1 1 0.05 0.25 1.86 5.00
6 INT184120 Il4 Positive_regulation of Stat6 3 0.09 2.39 0.67 5.00
7 INT332248 Ccl2 Positive_regulation of Ctgf 1 0.04 1.13 0.42 5.00
8 INT332255 Ptger2 Positive_regulation of Localization of Col7a1 1 0.00 0.92 0.31 5.00
9 INT332246 Ros1 Positive_regulation of Stat1 1 0.02 0.46 0.27 5.00
10 INT332242 Binding of Egf and Pdgfa 1 0.07 0.97 0.25 5.00
11 INT269994 Binding of Nfkb2 and Tpx2 1 0.04 0.51 0.21 5.00
12 INT269995 Positive_regulation of Binding of Nfkb2 and Tpx2 1 0.05 0.51 0.21 5.00
13 INT332247 Egf Positive_regulation of Stat6 1 0.13 1.23 0.19 5.00
14 INT332253 Il13 Positive_regulation of Stat6 1 0.08 1.18 0.19 5.00
15 INT332245 Pdgfa Positive_regulation of Stat6 1 0.07 1.22 0.19 5.00
16 INT332251 Il13 Positive_regulation of Stat1 1 0.14 1.4 0.18 5.00
17 INT221353 Tnf Positive_regulation of Gene_expression of RT1-CE1 1 0.05 0.39 0.16 5.00
18 INT332244 Il13 Positive_regulation of Gtf3a 1 0.01 1.21 0.15 5.00
19 INT198307 IL10 Positive_regulation of Gene_expression of IGHG3 2 0.01 1.21 0.15 5.00
20 INT221352 Tnf Negative_regulation of Il1a 1 0.05 0.3 0.15 5.00
21 INT332254 Pdgfa Positive_regulation of Stat3 1 0.02 0.52 0.14 5.00
22 INT332256 Pdgfa Positive_regulation of SOAT1 1 0.01 0.51 0.14 5.00
23 INT332243 Pdgfa Positive_regulation of Stat1 1 0.06 0.52 0.14 5.00
24 INT223084 Binding of Pdgfa and Pdgfb 2 0.17 0.83 0.13 5.00
25 INT332250 Stat6 Positive_regulation of Gene_expression of Pdgfa 1 0.05 1.33 0.12 5.00
26 INT332252 Stat6 Positive_regulation of Gene_expression of Il13 1 0.08 1.32 0.12 5.00
27 INT311010 SNRPB Positive_regulation of SERPINA10 1 0.00 0.69 0.07 5.00
28 INT310727 Binding of DKC1 and TERT 1 0.23 0.91 0.05 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Bronchiolitis Obliterans. They are ordered first by their pain relevance and then by number of times they were reported in Bronchiolitis Obliterans. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT96937 Gene_expression of Mmp9 191 0.75 150.3 56.01 99.84
2 INT155780 Gene_expression of Mmp8 19 0.77 15.85 6.33 99.84
3 INT184257 Positive_regulation of Gene_expression of Mmp8 7 0.49 6.32 2.74 99.84
4 INT113606 Positive_regulation of Gene_expression of Mmp9 46 0.64 44 15.07 99.84
5 INT220861 Positive_regulation of Mmp8 14 0.50 12.21 4.6 99.56
6 INT115384 Positive_regulation of Mmp9 121 0.68 94.74 43.02 99.16
7 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 98.80
8 INT23653 Binding of Egf 22 0.36 11.34 4.12 98.04
9 INT199559 Binding of Erbb2 5 0.36 4.23 0.36 98.04
10 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 97.80
11 INT76406 Gene_expression of Hmox1 140 0.78 85.86 17.15 96.64
12 INT164595 Binding of LCN2 8 0.37 6.03 0.6 95.12
13 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 92.68
14 INT96068 Positive_regulation of Timp1 30 0.58 23.94 8.17 92.40
15 INT97096 Regulation of Hmox1 18 0.61 6.42 3.9 87.88
16 INT146758 Gene_expression of LCN2 45 0.78 38.29 2.97 84.80
17 INT146757 Positive_regulation of Gene_expression of LCN2 5 0.69 7.21 0.72 84.80
18 INT168600 Binding of Mmp9 14 0.44 12.79 6.92 81.28
19 INT243030 Binding of Mmp8 1 0.10 2.4 1.82 80.48
20 INT311016 Regulation of Binding of LCN2 1 0.39 0.35 0.09 77.60
21 INT311015 Regulation of Gene_expression of LCN2 1 0.54 0.83 0.13 77.00
22 INT180525 Regulation of LCN2 4 0.54 4.37 0.18 76.56
23 INT337539 Gene_expression of IPCEF1 1 0.01 1.47 0.38 75.68
24 INT146759 Positive_regulation of LCN2 18 0.69 18.44 1.08 74.24
25 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 74.20
26 INT86780 Positive_regulation of Hmox1 145 0.70 117.09 31.18 74.08
27 INT270351 Negative_regulation of Ctsk 3 0.07 1.67 0.08 72.48
28 INT337765 Positive_regulation of Ctsk 1 0.06 0.57 0.03 72.48
29 INT10925 Positive_regulation of PIP 5 0.49 1.28 0.17 70.24
30 INT115130 Gene_expression of PDZK1IP1 5 0.65 1.95 1.79 69.80
31 INT115129 Positive_regulation of Gene_expression of PDZK1IP1 2 0.49 0.91 0.14 69.80
32 INT64123 Gene_expression of PIP 16 0.70 5.77 0.86 69.60
33 INT166451 Positive_regulation of Gene_expression of PIP 2 0.50 0.8 0.1 69.60
34 INT5788 Gene_expression of IL2RA 60 0.75 40.67 9.98 69.00
35 INT81293 Positive_regulation of Gene_expression of Hmox1 53 0.70 41.54 7.25 65.44
36 INT166452 Localization of PIP 1 0.74 0.5 0.09 57.88
37 INT128842 Localization of PDZK1IP1 3 0.73 0.5 0.7 57.52
38 INT130603 Binding of Timp1 9 0.35 8.52 3.04 54.64
39 INT311013 Negative_regulation of Gene_expression of LCN2 1 0.43 0.94 0.14 51.16
40 INT138915 Gene_expression of Stat1 144 0.77 69.53 5.85 47.04
41 INT138917 Positive_regulation of Gene_expression of Stat1 63 0.69 36.76 1.71 47.04
42 INT143234 Gene_expression of Nfkbia 10 0.62 5.2 5.02 39.04
43 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 35.28
44 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 34.72
45 INT4369 Gene_expression of Ldha 157 0.76 88.12 22.45 34.64
46 INT99742 Negative_regulation of Gene_expression of Hmox1 12 0.58 9.94 1.77 33.36
47 INT22708 Gene_expression of MUC1 297 0.78 232.71 24.19 33.12
48 INT3988 Positive_regulation of Gene_expression of IGHE 98 0.68 91.46 9.61 19.28
49 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 18.52
50 INT243034 Positive_regulation of Rarb 1 0.04 4.07 2.52 17.76
51 INT183450 Positive_regulation of GUCY2C 6 0.04 4.45 1.88 16.52
52 INT57875 Positive_regulation of Positive_regulation of Egr1 6 0.49 2.74 1.75 15.36
53 INT57876 Positive_regulation of Egr1 46 0.70 25.6 9.41 14.36
54 INT310728 Binding of DKC1 1 0.25 2.36 0.38 11.44
55 INT149138 Binding of PDX1 27 0.37 32.62 9.33 10.68
56 INT82450 Negative_regulation of Hmox1 33 0.55 19.07 8.12 6.36
57 INT82568 Protein_catabolism of Hmox1 5 0.86 1.03 0.79 6.36
58 INT171060 Gene_expression of PDX1 72 0.75 72.57 17.97 5.40
59 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
60 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
61 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 5.00
62 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
63 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
64 INT626 Localization of CALCA 289 0.81 125.39 221.15 5.00
65 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
66 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
67 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59 5.00
68 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 5.00
69 INT13353 Positive_regulation of Tnf 332 0.70 248.75 148.1 5.00
70 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
71 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
72 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
73 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 5.00
74 INT27096 Positive_regulation of Nfkb1 325 0.70 195.11 109.06 5.00
75 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
76 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
77 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
78 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
79 INT10272 Gene_expression of Il1b 194 0.78 121.02 103.03 5.00
80 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
81 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5 5.00
82 INT5056 Gene_expression of IFNG 216 0.78 137.52 74.57 5.00
83 INT10274 Positive_regulation of Il1b 123 0.70 79.76 73.56 5.00
84 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
85 INT39565 Gene_expression of Ptger2 424 0.75 229.28 72.68 5.00
86 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71 5.00
87 INT49995 Positive_regulation of Gene_expression of Tnf 187 0.70 125.07 70.54 5.00
88 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
89 INT1425 Gene_expression of Rbm39 143 0.58 51.32 65.44 5.00
90 INT11937 Localization of Il6 228 0.81 139.83 64.39 5.00
91 INT55344 Gene_expression of Ros1 396 0.54 217.64 59.98 5.00
92 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81 5.00
93 INT48891 Positive_regulation of Il10 143 0.70 101.42 56.72 5.00
94 INT5770 Binding of Rbm39 88 0.41 13.23 55.5 5.00
95 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 5.00
96 INT12345 Gene_expression of Il2 142 0.78 59.17 51.21 5.00
97 INT73502 Positive_regulation of IL10 154 0.69 124.87 43.5 5.00
98 INT5307 Regulation of Tnf 87 0.62 78.71 43.4 5.00
99 INT100939 Gene_expression of Il13 176 0.73 125.1 43.38 5.00
100 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 5.00
101 INT48222 Positive_regulation of Localization of IL8 123 0.59 78.04 37.2 5.00
102 INT63349 Gene_expression of PECAM1 199 0.75 166.03 36.76 5.00
103 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 5.00
104 INT3679 Gene_expression of AVP 171 0.78 72.9 35.23 5.00
105 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 5.00
106 INT104392 Gene_expression of Cxcl10 113 0.75 106.86 34.12 5.00
107 INT13186 Positive_regulation of Il4 113 0.68 71.22 31.4 5.00
108 INT145426 Positive_regulation of Ros1 185 0.56 106.76 27.21 5.00
109 INT59449 Negative_regulation of Timp1 76 0.42 54.86 26.99 5.00
110 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 5.00
111 INT19856 Gene_expression of CD8A 240 0.75 147.86 26.39 5.00
112 INT10273 Positive_regulation of Gene_expression of Il1b 47 0.68 31.15 26.21 5.00
113 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 5.00
114 INT5948 Regulation of Il1b 44 0.60 22.8 25.4 5.00
115 INT68758 Positive_regulation of Ros1 125 0.46 82.72 25.27 5.00
116 INT86295 Gene_expression of Mmp2 114 0.76 73.68 24.25 5.00
117 INT27933 Gene_expression of NCOR2 65 0.72 31.35 24.23 5.00
118 INT72370 Gene_expression of Timp1 82 0.65 57.52 24.16 5.00
119 INT66758 Binding of Nfkb1 97 0.48 50.65 23.65 5.00
120 INT8775 Binding of IGHE 167 0.48 102.61 23.54 5.00
121 INT35716 Positive_regulation of NCOR2 45 0.60 18 23.54 5.00
122 INT50039 Positive_regulation of Il4 48 0.55 34.8 23.34 5.00
123 INT5055 Positive_regulation of IFNG 89 0.69 64.03 23.05 5.00
124 INT48081 Localization of Il1b 46 0.80 21.59 22.4 5.00
125 INT150022 Positive_regulation of Il17a 69 0.64 70.04 21.87 5.00
126 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 5.00
127 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31 5.00
128 INT72060 Positive_regulation of Gene_expression of Ros1 127 0.41 76.76 20.91 5.00
129 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
130 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44 5.00
131 INT19509 Localization of Ifng 55 0.78 28.25 18.67 5.00
132 INT56301 Positive_regulation of IL4 68 0.56 54.51 18.65 5.00
133 INT65260 Positive_regulation of Col7a1 95 0.69 61.73 18.42 5.00
134 INT5967 Negative_regulation of Il1a 51 0.57 27.09 18.24 5.00
135 INT132997 Localization of Mmp9 59 0.80 45.9 17.61 5.00
136 INT95767 Negative_regulation of Mmp9 72 0.57 49.14 17.1 5.00
137 INT25223 Positive_regulation of Gene_expression of IFNG 41 0.67 36.97 15.89 5.00
138 INT96775 Gene_expression of Pdgfa 42 0.54 29.78 15.46 5.00
139 INT24670 Gene_expression of FGF2 121 0.78 85.64 15.12 5.00
140 INT129584 Positive_regulation of Stat3 97 0.68 87.07 14.86 5.00
141 INT100938 Positive_regulation of Il13 47 0.69 42.11 14.36 5.00
142 INT36262 Positive_regulation of Tbce 35 0.49 28.79 14.33 5.00
143 INT10173 Binding of Tnf 45 0.48 35.6 14.32 5.00
144 INT22098 Positive_regulation of Il2 27 0.69 14.77 14.1 5.00
145 INT64048 Positive_regulation of Positive_regulation of Tnf 32 0.70 21.24 13.74 5.00
146 INT56651 Binding of HLA-DRB1 58 0.48 52.25 13.68 5.00
147 INT120901 Positive_regulation of Gene_expression of Il13 36 0.57 31.63 13.36 5.00
148 INT99780 Positive_regulation of Cxcl10 43 0.69 39.67 13.27 5.00
149 INT170601 Positive_regulation of Gene_expression of GOPC 122 0.43 42.79 11.68 5.00
150 INT49509 Negative_regulation of Ptger2 53 0.42 24.87 11.66 5.00
151 INT16449 Binding of IGHG3 67 0.48 39.55 10.59 5.00
152 INT29740 Gene_expression of ANG 55 0.78 24.53 9.86 5.00
153 INT126031 Negative_regulation of Gene_expression of MMP9 40 0.57 22.71 9.79 5.00
154 INT35164 Negative_regulation of IGHE 96 0.58 76.3 9.74 5.00
155 INT114874 Gene_expression of Stat3 78 0.76 53.99 9.49 5.00
156 INT24328 Gene_expression of Egf 97 0.75 59.65 9.42 5.00
157 INT140224 Localization of Ccl2 32 0.72 26.91 9.39 5.00
158 INT60436 Negative_regulation of COPD 76 0.37 84.22 9.08 5.00
159 INT25381 Localization of Csf2 62 0.76 47.48 9.03 5.00
160 INT158796 Positive_regulation of SMUG1 67 0.70 38.97 8.98 5.00
161 INT150867 Regulation of COPD 54 0.48 71.38 8.8 5.00
162 INT104394 Positive_regulation of Gene_expression of Cxcl10 28 0.65 25.64 8.79 5.00
163 INT111397 Localization of Timp1 17 0.70 11.67 8.76 5.00
164 INT44550 Positive_regulation of Gene_expression of AVP 38 0.70 22.27 8.62 5.00
165 INT79693 Regulation of Il4 30 0.51 21.96 8.6 5.00
166 INT86705 Gene_expression of BTG3 41 0.65 37.29 8.29 5.00
167 INT8694 Binding of Lgals3 38 0.48 14.82 8.05 5.00
168 INT126478 Gene_expression of Cxcl12 78 0.77 58.69 8.01 5.00
169 INT62452 Regulation of Il2 14 0.61 12.11 7.64 5.00
170 INT76892 Gene_expression of FGFR1 45 0.69 23.6 7.56 5.00
171 INT8684 Positive_regulation of ANGPTL5 45 0.69 36.29 7.47 5.00
172 INT121496 Gene_expression of TERT 107 0.78 45.6 7.42 5.00
173 INT53189 Gene_expression of VSX1 32 0.69 10.59 7.21 5.00
174 INT138922 Positive_regulation of Stat1 57 0.69 28.35 7.2 5.00
175 INT76120 Gene_expression of Ptprc 102 0.59 30.42 7.02 5.00
176 INT49506 Regulation of Ptger2 29 0.44 17.38 6.75 5.00
177 INT13520 Binding of HLA-DRB4 30 0.42 32.65 6.74 5.00
178 INT23246 Gene_expression of HLA-DRB4 37 0.64 36.79 6.61 5.00
179 INT181525 Localization of Il13 24 0.66 21.51 6.55 5.00
180 INT166707 Protein_catabolism of Col7a1 24 0.74 20.47 6.39 5.00
181 INT2442 Localization of Mb 38 0.80 24.74 6.33 5.00
182 INT65265 Positive_regulation of Gene_expression of Col7a1 48 0.69 23.81 6.16 5.00
183 INT126481 Gene_expression of Cxcr4 69 0.77 34.99 6 5.00
184 INT15132 Gene_expression of TNFRSF1A 33 0.75 20.09 5.93 5.00
185 INT86111 Positive_regulation of Positive_regulation of VEGFA 38 0.69 33.81 5.78 5.00
186 INT3306 Localization of Tbce 16 0.12 8.24 5.71 5.00
187 INT96778 Positive_regulation of Pdgfa 22 0.46 12.7 5.31 5.00
188 INT6476 Gene_expression of TNFRSF1B 21 0.67 18.22 5.25 5.00
189 INT62525 Positive_regulation of SELE 38 0.70 46 5.25 5.00
190 INT134966 Localization of Col7a1 23 0.42 16.4 5.24 5.00
191 INT95131 Binding of Cd4 27 0.37 21.62 5.07 5.00
192 INT19187 Gene_expression of Lgals3 24 0.73 19.72 5.03 5.00
193 INT26583 Positive_regulation of Cd4 40 0.54 21.96 4.83 5.00
194 INT58766 Gene_expression of ANGPT2 41 0.67 21.65 4.82 5.00
195 INT82354 Positive_regulation of PECAM1 25 0.34 22.93 4.69 5.00
196 INT2065 Binding of BTG3 15 0.36 10.9 4.65 5.00
197 INT101594 Positive_regulation of Cd40 36 0.69 16.14 4.56 5.00
198 INT186270 Regulation of Il13 13 0.43 11.58 4.19 5.00
199 INT96776 Positive_regulation of Gene_expression of Pdgfa 8 0.40 7.79 3.93 5.00
200 INT180922 Negative_regulation of Mmp8 4 0.43 8.35 3.72 5.00
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