D:Bundle-branch Block

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Disease Term
Synonyms ANTERIOR FASCICULAR BLOCK, ANTERIOR FASCICULAR BLOCKS, Block Anterior Fascicular, Block Bundle Branch, Block Fascicular, Block Left Bundle Branch, Block Posterior Fascicular, Block Right Bundle Branch, Blocks Anterior Fascicular, Blocks Bundle Branch, Blocks Fascicular
Documents 446
Hot Single Events 42
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Bundle-branch Block. They are ordered first by their relevance to Bundle-branch Block and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT329586 Binding of UBAP1 and ACCS 1 0.00 1.08 0.25 46.24
2 INT334894 Binding of CALCR and ARMC9 1 0.01 0.41 0 39.12
3 INT231206 Binding of KCNH2 and KCNQ1 2 0.22 1.04 0.24 36.28
4 INT264988 Binding of CYP2C19 and CYP3A4 1 0.18 0.72 1.09 5.00
5 INT264987 Binding of CYP2C9 and CYP3A4 1 0.19 0.71 1.08 5.00
6 INT329589 Serpina5 Positive_regulation of PTX3 1 0.03 1.52 0.66 5.00
7 INT248135 Binding of IDS and ACCS 1 0.09 1.12 0.51 5.00
8 INT271344 MPO Regulation of Protein_catabolism of ACCS 1 0.02 2.42 0.51 5.00
9 INT329587 Binding of PTX3 and HEY1 1 0.00 2.03 0.5 5.00
10 INT271350 MPO Positive_regulation of TIMP1 1 0.05 1.66 0.29 5.00
11 INT194045 Binding of CRP and PM20D2 1 0.01 1.64 0.27 5.00
12 INT194047 Negative_regulation of Binding of CRP and PM20D2 1 0.02 1.57 0.23 5.00
13 INT194046 Binding of IL6 and PM20D2 1 0.01 1.71 0.22 5.00
14 INT89612 Binding of FABP3 and MB 3 0.34 1.49 0.22 5.00
15 INT247656 Binding of Tnnc1 and Gdf15 1 0.02 0.94 0.16 5.00
16 INT271345 Negative_regulation of PIGF Negative_regulation of FLT1 1 0.02 1.17 0.13 5.00
17 INT231223 Binding of KCNQ1 and Nav1 1 0.03 0.59 0.11 5.00
18 INT276497 F3 Positive_regulation of F7 1 0.02 1.64 0.1 5.00
19 INT334893 ACE Negative_regulation of Gene_expression of AGT 1 0.03 1.41 0.1 5.00
20 INT271343 Binding of CRP and PAPPA 1 0.20 0.86 0.1 5.00
21 INT276495 TF Positive_regulation of F7 1 0.23 1.63 0.1 5.00
22 INT271349 ACCS Positive_regulation of PAPPA 1 0.06 0.87 0.09 5.00
23 INT276496 Binding of TF and F7 1 0.18 0.81 0.08 5.00
24 INT271347 Negative_regulation of Binding of TNNT2 and ACCS 1 0.01 0.67 0.08 5.00
25 INT271354 MPO Regulation of Gene_expression of CRP 1 0.16 1.74 0.08 5.00
26 INT271346 Binding of TNNT2 and ACCS 1 0.01 0.67 0.08 5.00
27 INT271351 MPO Positive_regulation of CRP 1 0.07 1.69 0.08 5.00
28 INT273520 NBN Positive_regulation of CDIPT 1 0.06 0.82 0.08 5.00
29 INT271355 PGF Positive_regulation of PIGF 1 0.01 0.99 0.06 5.00
30 INT106823 Binding of MBP and PAPPA 2 0.17 3.89 0.05 5.00
31 INT248134 IDS Positive_regulation of CHDH 1 0.08 1.52 0.05 5.00
32 INT273519 NBN Negative_regulation of YOD1 1 0.03 0.56 0.03 5.00
33 INT271328 FABP3 Positive_regulation of Binding of FABP3 and MB 1 0.00 0.81 0.03 5.00
34 INT191899 Binding of EXOSC10 and PNN 1 0.00 0.96 0.03 5.00
35 INT352175 USE1 Regulation of NAGA 1 0.01 0.33 0 5.00
36 INT189396 MBD4 Regulation of C11orf2 1 0.05 0.66 0 5.00
37 INT285231 Binding of CHKB and TNNT1 1 0.15 0.05 0 5.00
38 INT276493 TFPI Regulation of TF 1 0.12 0.17 0 5.00
39 INT191900 Binding of EXOSC10 and COPD 1 0.01 0.53 0 5.00
40 INT271348 Binding of CHKB and MB 1 0.01 1.01 0 5.00
41 INT273518 Binding of ALB and NBN 1 0.06 0.47 0 5.00
42 INT285232 Binding of CHKB and LDHA 1 0.06 0.1 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Bundle-branch Block. They are ordered first by their pain relevance and then by number of times they were reported in Bundle-branch Block. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT65076 Positive_regulation of SLC5A6 1 0.41 3.28 0.4 100.00
2 INT3590 Positive_regulation of AVL9 7 0.40 7.94 2.36 99.90
3 INT3589 Positive_regulation of SCN5A 101 0.57 46.01 21.73 99.90
4 INT63296 Positive_regulation of TRGV9 3 0.60 1.39 0.42 99.90
5 INT57252 Negative_regulation of PGR 22 0.43 12.95 3.33 99.12
6 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 99.08
7 INT193268 Binding of Brs3 3 0.03 1.56 2.67 97.92
8 INT647 Gene_expression of SGCG 211 0.75 78.46 55.82 97.62
9 INT118666 Negative_regulation of AVPR1B 7 0.43 2.88 0.59 96.48
10 INT45342 Binding of AVSD1 6 0.31 7.23 0.27 96.48
11 INT118668 Negative_regulation of TRGV9 6 0.37 2.58 1.23 96.24
12 INT68496 Binding of PGR 26 0.48 16.36 2.09 96.16
13 INT101906 Negative_regulation of AVL9 2 0.32 2.1 0.68 96.04
14 INT719 Negative_regulation of SGCG 96 0.57 47.91 30.22 95.48
15 INT27242 Gene_expression of PGR 153 0.75 98.77 12.79 94.96
16 INT68189 Gene_expression of TNNT1 27 0.75 14.87 4.03 94.68
17 INT176063 Positive_regulation of SQLE 4 0.36 4.28 1 94.08
18 INT9548 Gene_expression of CHKB 99 0.65 50.86 9.03 92.96
19 INT323416 Localization of NKX2-5 1 0.65 1.75 0.1 91.76
20 INT97452 Positive_regulation of MOCS1 20 0.39 11.4 2.59 91.40
21 INT22882 Negative_regulation of IMPA1 10 0.57 5.19 0.31 90.36
22 INT101687 Positive_regulation of AVPR1B 6 0.40 2.95 0.95 90.08
23 INT10353 Positive_regulation of PGR 34 0.70 21.84 3.28 90.04
24 INT93886 Positive_regulation of Gene_expression of PGR 19 0.52 15.78 1.89 90.04
25 INT199206 Negative_regulation of Ict1 9 0.05 3.67 0.21 88.08
26 INT65075 Positive_regulation of Binding of SLC5A6 1 0.41 1.63 0.22 87.96
27 INT24736 Positive_regulation of SERPINA5 17 0.49 9.55 1.47 87.44
28 INT65077 Binding of SLC5A6 1 0.31 1.63 0.22 87.32
29 INT240519 Regulation of Scn8a 3 0.06 0.9 0.71 87.00
30 INT247649 Negative_regulation of Gene_expression of Tnnc1 1 0.03 0.49 0.08 86.08
31 INT9552 Positive_regulation of TNNI3 209 0.70 128.67 19.15 85.88
32 INT77490 Positive_regulation of Tnnc1 85 0.68 43.54 9.07 85.84
33 INT93789 Gene_expression of Tnnc1 28 0.76 17.3 1.99 85.84
34 INT227663 Localization of IDS 14 0.63 7.64 1.85 85.36
35 INT8683 Positive_regulation of F3 31 0.67 42.89 6.21 84.32
36 INT193632 Positive_regulation of ARVD4 2 0.01 2.73 0.11 83.32
37 INT30209 Localization of SCN5A 24 0.72 7.95 5.35 82.00
38 INT193271 Gene_expression of Brs3 8 0.05 1.25 5.87 81.92
39 INT45427 Positive_regulation of Cacna2d2 20 0.49 11.89 4.85 81.64
40 INT85297 Positive_regulation of Gene_expression of TNNI3 29 0.50 29.77 1.68 81.56
41 INT11551 Localization of VHL 12 0.65 22.76 0.68 81.12
42 INT9550 Gene_expression of TNNI3 113 0.78 86.79 10.56 81.00
43 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 80.00
44 INT2890 Positive_regulation of MB 39 0.70 29.58 6.01 80.00
45 INT156639 Localization of Hcm 5 0.64 7.65 0.16 79.92
46 INT1530 Regulation of Gh 382 0.61 115.96 112.47 79.84
47 INT273525 Regulation of NBN 1 0.49 1.28 0.05 79.20
48 INT45971 Negative_regulation of GOT1 9 0.51 6.2 2.84 78.00
49 INT251 Regulation of INS 398 0.62 232.47 55.04 77.84
50 INT110110 Gene_expression of ACCS 85 0.58 75.88 10.2 76.72
51 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 75.76
52 INT191235 Regulation of Ecg2 1 0.00 2.64 0.47 69.68
53 INT636 Binding of MRAP 54 0.48 40.36 18.77 69.08
54 INT24472 Positive_regulation of Brs3 5 0.28 1 1.73 69.04
55 INT124300 Negative_regulation of Sod2 17 0.45 12.54 0.9 67.92
56 INT11764 Positive_regulation of ENG 78 0.61 27.65 33.69 66.08
57 INT71680 Gene_expression of CCL3 43 0.75 33.7 18.01 62.96
58 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 62.24
59 INT217952 Negative_regulation of MYH7 2 0.01 1.85 0.09 62.12
60 INT24907 Gene_expression of PAPPA 42 0.75 28.32 6.63 62.08
61 INT260849 Gene_expression of NBN 9 0.67 7.11 0.16 61.68
62 INT20672 Gene_expression of CDS1 19 0.76 8.19 4.08 61.52
63 INT74158 Positive_regulation of Gene_expression of CDS1 2 0.43 1.05 0.15 61.52
64 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 61.36
65 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 61.12
66 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58 60.96
67 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 60.64
68 INT7534 Gene_expression of Ifng 193 0.78 111.02 68.6 58.64
69 INT232511 Regulation of PROM1 7 0.27 4.91 0.16 56.24
70 INT2393 Positive_regulation of Mb 174 0.69 93.59 26.79 55.68
71 INT132662 Binding of Hcm 11 0.31 14.41 0.73 55.00
72 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 54.72
73 INT24471 Regulation of Brs3 3 0.17 1.56 2.19 54.64
74 INT57424 Positive_regulation of TNNT1 42 0.67 31.84 9.7 54.40
75 INT61791 Positive_regulation of SH2B2 9 0.50 8.36 2.99 51.52
76 INT28703 Negative_regulation of TFPI 29 0.38 19.81 4.93 50.96
77 INT100360 Negative_regulation of TF 19 0.42 10.43 2.68 50.96
78 INT247653 Gene_expression of Gdf15 10 0.64 7.56 1.11 49.08
79 INT166819 Gene_expression of IMPA1 12 0.65 3.85 1.77 48.56
80 INT9840 Positive_regulation of F7 17 0.57 17.83 2.08 47.04
81 INT60279 Gene_expression of VHL 70 0.78 75.21 2.21 46.12
82 INT6782 Gene_expression of SCN5A 156 0.78 33.13 17.88 44.48
83 INT242236 Positive_regulation of Ptpn1 3 0.33 1.11 0.07 44.44
84 INT200219 Positive_regulation of VHL 18 0.50 15.38 0.67 43.56
85 INT217719 Positive_regulation of IDS 19 0.40 3.93 0.63 41.92
86 INT212271 Binding of ARMC9 14 0.27 3.29 0.43 41.60
87 INT242237 Localization of Ptpn1 1 0.16 0.34 0.05 41.04
88 INT74016 Binding of VHL 20 0.48 15.49 0.54 40.84
89 INT47662 Localization of CHKB 34 0.81 22.63 5.14 38.56
90 INT11367 Localization of MB 9 0.78 9.34 1.24 38.56
91 INT59194 Gene_expression of STS 18 0.59 6.74 1.89 38.40
92 INT9832 Gene_expression of Shbg 96 0.75 56.71 12.19 38.24
93 INT20631 Positive_regulation of CHKB 166 0.69 109.86 17.92 37.56
94 INT268232 Phosphorylation of PTGIR 4 0.11 1.91 0.95 36.08
95 INT37865 Positive_regulation of Alad 5 0.27 3.13 0.6 33.92
96 INT86023 Transcription of PPARA 60 0.66 25.8 5.7 31.76
97 INT242239 Binding of Ptpn1 1 0.08 2.01 0.68 31.52
98 INT200462 Binding of IDS 13 0.31 4.95 1 31.36
99 INT212171 Gene_expression of CDIPT 5 0.37 2.58 2.92 30.72
100 INT98687 Gene_expression of Calr 38 0.61 7.03 1.59 29.92
101 INT198961 Gene_expression of SPINK7 5 0.18 6.02 0.05 25.32
102 INT36411 Positive_regulation of Ecg2 4 0.03 3.5 0.36 22.84
103 INT139366 Gene_expression of PROM1 98 0.77 67.84 3.39 22.16
104 INT78210 Gene_expression of MCC 7 0.65 1.8 0.98 20.52
105 INT114709 Gene_expression of Fga 5 0.58 0.92 0.22 17.88
106 INT16167 Negative_regulation of DMD 186 0.57 108.71 15.25 17.36
107 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 16.16
108 INT78182 Positive_regulation of ACCS 43 0.43 46.39 6.78 13.32
109 INT34143 Regulation of IMPA1 14 0.44 4.83 0.58 12.04
110 INT100861 Binding of CRP 179 0.48 175.2 26.45 7.92
111 INT199209 Regulation of Ict1 4 0.05 2.53 0.03 5.72
112 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
113 INT87687 Positive_regulation of Trpv1 409 0.70 210.24 257.59 5.00
114 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
115 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
116 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02 5.00
117 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
118 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
119 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
120 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
121 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 5.00
122 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 5.00
123 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 5.00
124 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
125 INT9382 Regulation of TRPV1 149 0.62 53.99 77.46 5.00
126 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.00
127 INT1080 Negative_regulation of Ache 343 0.59 108.51 72.4 5.00
128 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 5.00
129 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 5.00
130 INT1169 Negative_regulation of Bche 322 0.59 149.22 61.27 5.00
131 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
132 INT1536 Negative_regulation of NA 244 0.55 52.67 59.79 5.00
133 INT6623 Gene_expression of NA 231 0.78 45.78 59.36 5.00
134 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 5.00
135 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 5.00
136 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 5.00
137 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81 5.00
138 INT48232 Gene_expression of MMP1 245 0.78 96.31 57.72 5.00
139 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 5.00
140 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
141 INT9234 Negative_regulation of Gene_expression of IL6 171 0.59 101.61 53.15 5.00
142 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 5.00
143 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
144 INT9210 Regulation of IL6 166 0.62 125.61 49.95 5.00
145 INT22454 Regulation of Crp 213 0.62 160.67 49.24 5.00
146 INT51163 Gene_expression of Gal 119 0.78 67.48 49.23 5.00
147 INT26500 Gene_expression of MMP2 201 0.78 110.57 46.9 5.00
148 INT98498 Binding of Trpv1 75 0.48 33.67 44.4 5.00
149 INT2774 Binding of Crp 241 0.48 195.89 44.39 5.00
150 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
151 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 5.00
152 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 5.00
153 INT11939 Negative_regulation of Il6 138 0.59 87.46 41.24 5.00
154 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 5.00
155 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
156 INT4449 Positive_regulation of NA 179 0.55 40.26 37.82 5.00
157 INT63349 Gene_expression of PECAM1 199 0.75 166.03 36.76 5.00
158 INT12892 Negative_regulation of TIMP1 136 0.58 83.13 36.54 5.00
159 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53 5.00
160 INT5743 Localization of NA 104 0.59 14.35 35.29 5.00
161 INT103094 Binding of PPARA 308 0.47 177.26 34.75 5.00
162 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19 5.00
163 INT16960 Gene_expression of Crp 166 0.76 116.21 34.07 5.00
164 INT99610 Localization of MMP9 126 0.79 48.46 32.67 5.00
165 INT62830 Gene_expression of VCAM1 149 0.78 125.23 32.4 5.00
166 INT88318 Gene_expression of CXCR4 208 0.77 189.67 31.72 5.00
167 INT94388 Gene_expression of GDF15 124 0.77 79.48 31.42 5.00
168 INT608 Negative_regulation of KNG1 98 0.43 72.36 31.23 5.00
169 INT86437 Binding of IL6 154 0.48 121.22 29.3 5.00
170 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6 5.00
171 INT10799 Localization of ENG 63 0.78 18.67 27.28 5.00
172 INT129956 Gene_expression of MMP13 145 0.72 60.48 26.98 5.00
173 INT73047 Positive_regulation of MMP9 133 0.68 73.22 26.42 5.00
174 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 5.00
175 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 5.00
176 INT147792 Gene_expression of COPD 230 0.70 287.13 24.1 5.00
177 INT49196 Gene_expression of SELE 105 0.78 107.29 22.92 5.00
178 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73 5.00
179 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91 5.00
180 INT23257 Regulation of CRP 127 0.62 100.05 21.87 5.00
181 INT73625 Gene_expression of PPARG 108 0.78 104.85 21.42 5.00
182 INT101517 Negative_regulation of PPARA 168 0.57 112.24 21.41 5.00
183 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31 5.00
184 INT60779 Negative_regulation of CYP3A 63 0.59 8.38 21.27 5.00
185 INT4535 Localization of PROC 106 0.73 76.24 21.1 5.00
186 INT125312 Positive_regulation of COPD 134 0.59 162.55 20.27 5.00
187 INT52457 Gene_expression of ABCB1 129 0.78 38.68 19.88 5.00
188 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 5.00
189 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59 5.00
190 INT14306 Positive_regulation of Gal 36 0.70 21.66 18.51 5.00
191 INT18010 Positive_regulation of CD40LG 122 0.70 100.8 18.46 5.00
192 INT70970 Binding of COPD 144 0.42 180.34 18.29 5.00
193 INT55880 Negative_regulation of Gene_expression of CCL2 49 0.59 22.37 18.09 5.00
194 INT50403 Negative_regulation of CYP2C19 55 0.59 8.97 17.79 5.00
195 INT2216 Gene_expression of SELL 92 0.77 59.29 17.71 5.00
196 INT103245 Positive_regulation of Gene_expression of MMP9 64 0.68 36.86 15.7 5.00
197 INT59929 Negative_regulation of CYP2C9 60 0.59 16.33 15.39 5.00
198 INT26501 Positive_regulation of Gene_expression of MMP2 51 0.67 39 15.16 5.00
199 INT505 Positive_regulation of GPT 89 0.67 69.38 14.94 5.00
200 INT74587 Gene_expression of MMP8 31 0.78 24.4 14.91 5.00
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