D:Cadasil

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pChart

Disease Term
Synonyms Cadasilm
Documents 162
Hot Single Events 39
Hot Interactions 5

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Cadasil. They are ordered first by their relevance to Cadasil and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT161086 NOTCH3 Regulation of Notch3 1 0.51 1.06 0.14 100.00
2 INT251730 Binding of CD70 and SUGT1 1 0.01 0.85 0.49 99.92
3 INT251731 Binding of CD70 and SNRNP70 1 0.04 0.84 0.49 99.92
4 INT251729 Binding of FEN1 and EXOSC1 1 0.19 1.13 0.74 90.72
5 INT273887 Binding of Jag1 and Notch2 1 0.02 1.06 0 86.40
6 INT342165 Binding of Aqp1 and Nav1 1 0.25 0.57 1.25 5.00
7 INT219154 Binding of HMGB1 and TLR4 2 0.17 4.45 0.93 5.00
8 INT342164 Binding of Csf2 and Nkx2-1 1 0.01 0.52 0.26 5.00
9 INT336946 Binding of ITGA4 and VCAM1 1 0.03 2.02 0.21 5.00
10 INT342163 Nkx2-1 Regulation of Gene_expression of Aqp1 1 0.06 0.51 0.2 5.00
11 INT327879 Binding of Itgb1 and Postn 1 0.02 1.05 0.14 5.00
12 INT327877 Itgb1 Negative_regulation of Gene_expression of Dlk1 1 0.02 0.99 0.13 5.00
13 INT327871 Binding of Notch1 and Postn 1 0.38 1.42 0.07 5.00
14 INT327875 Binding of Col7a1 and Postn 1 0.02 0.58 0.04 5.00
15 INT327876 Postn Regulation of Gene_expression of Notch1 1 0.56 0.92 0.03 5.00
16 INT327870 Postn Positive_regulation of Gene_expression of Notch1 1 0.37 0.57 0 5.00
17 INT327873 Postn Regulation of Notch1 1 0.41 0 0 5.00
18 INT327878 Binding of Egf and Postn 1 0.18 0.37 0 5.00
19 INT273886 Binding of Dll1 and Trip12 1 0.34 0.1 0 5.00
20 INT273885 Binding of Mul1 and Cul2 1 0.06 0 0 5.00
21 INT327872 Binding of Postn and Pkn1 1 0.03 0.21 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Cadasil. They are ordered first by their pain relevance and then by number of times they were reported in Cadasil. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT49505 Binding of NOTCH3 6 0.47 6.4 1.03 100.00
2 INT136931 Negative_regulation of NOTCH3 1 0.42 1.08 0.13 100.00
3 INT83734 Negative_regulation of RLS 24 0.50 35.75 5.66 100.00
4 INT64253 Localization of NOTCH3 1 0.78 0.97 0.16 100.00
5 INT64252 Negative_regulation of Localization of NOTCH3 1 0.41 0.97 0.16 100.00
6 INT146421 Binding of Notch3 2 0.35 1.94 0.17 99.98
7 INT148562 Positive_regulation of GNAS 13 0.16 5.31 1.32 99.74
8 INT169818 Negative_regulation of Notch3 1 0.38 1.19 0.06 99.56
9 INT161085 Positive_regulation of Notch3 4 0.41 4.36 0.27 99.52
10 INT104284 Positive_regulation of Notch3 7 0.50 5.57 0.99 99.20
11 INT329021 Regulation of Gene_expression of Notch3 1 0.09 2.04 0 98.98
12 INT329022 Gene_expression of Notch3 1 0.27 2.04 0 98.98
13 INT287448 Gene_expression of Tagln 6 0.65 3.73 0.16 98.16
14 INT287445 Regulation of Tagln 2 0.29 2.59 0.08 97.96
15 INT219329 Transcription of NOTCH3 1 0.69 0.48 0.03 95.16
16 INT121954 Binding of Mthfr 17 0.44 13.47 4.66 94.84
17 INT136921 Gene_expression of NOTCH3 5 0.67 4.27 0.16 94.52
18 INT169180 Binding of SNRNP70 204 0.47 119.1 29.3 94.08
19 INT6481 Binding of TNF 624 0.48 510.2 214.82 93.88
20 INT251733 Binding of CD70 1 0.27 0.76 0.22 93.76
21 INT107611 Regulation of Notch3 2 0.42 0.89 0.23 93.20
22 INT83797 Gene_expression of Bcl2l1 124 0.77 94.55 22.39 92.68
23 INT83798 Negative_regulation of Gene_expression of Bcl2l1 28 0.58 20.26 4.21 92.68
24 INT54924 Gene_expression of RLS 67 0.62 83.2 14.25 92.40
25 INT121347 Binding of GNAS 8 0.13 3.99 1.47 92.24
26 INT22548 Positive_regulation of Casp3 483 0.70 258.78 213.07 92.08
27 INT101726 Gene_expression of Notch3 4 0.77 4.87 0.64 91.28
28 INT251735 Binding of FEN1 1 0.17 1.13 0.74 90.72
29 INT251734 Localization of CD70 1 0.69 3.93 2.42 90.28
30 INT113676 Gene_expression of NRP1 22 0.72 10.81 1.71 90.00
31 INT32933 Gene_expression of GNAS 57 0.32 10.58 4.03 89.24
32 INT52633 Negative_regulation of Notch1 4 0.42 2.99 1.84 89.12
33 INT71168 Positive_regulation of CRYAB 1 0.38 0.68 0.06 87.48
34 INT110209 Localization of Notch3 2 0.75 1.82 0.15 85.28
35 INT273867 Binding of Jag1 18 0.45 3.14 0.25 82.88
36 INT9900 Positive_regulation of Vwf 80 0.69 51.85 18.13 82.12
37 INT122812 Gene_expression of SNRNP70 130 0.75 67 12.5 80.68
38 INT191164 Gene_expression of CD70 5 0.66 3.01 0.59 80.68
39 INT104283 Negative_regulation of Gene_expression of Notch3 1 0.39 0.84 0.06 80.56
40 INT8866 Positive_regulation of TAT 30 0.67 18.06 5.57 70.00
41 INT11710 Positive_regulation of SERPINC1 6 0.59 6.15 1.47 70.00
42 INT75742 Binding of RLS 86 0.42 95.27 19.04 68.28
43 INT13544 Localization of LTA 9 0.78 6.34 1.8 68.20
44 INT219752 Localization of EXOSC1 4 0.78 6.92 1.19 66.12
45 INT241191 Positive_regulation of Kctd1 2 0.06 4.28 0.16 59.44
46 INT327857 Positive_regulation of Protein_catabolism of Psmd1 1 0.01 0.68 0 52.96
47 INT327868 Protein_catabolism of Psmd1 1 0.02 0.68 0 52.08
48 INT232397 Protein_catabolism of Notch1 3 0.64 1.56 0 52.08
49 INT83607 Positive_regulation of CSAD 13 0.59 14.24 8.07 52.00
50 INT6830 Positive_regulation of Notch1 20 0.55 7.91 1.57 49.44
51 INT35143 Negative_regulation of ANGPTL5 28 0.54 18.59 3.14 45.12
52 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 36.96
53 INT84909 Positive_regulation of SUGT1 22 0.08 22.01 5.43 36.96
54 INT272837 Phosphorylation of Kctd1 1 0.11 1.56 0.07 36.88
55 INT85328 Negative_regulation of Aqp1 5 0.54 6.02 4.94 26.80
56 INT98613 Gene_expression of CSAD 7 0.53 7.86 4.8 23.00
57 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 21.44
58 INT85326 Positive_regulation of Aqp1 7 0.65 5.9 3.71 17.92
59 INT193945 Binding of Notch1 7 0.15 1.28 0.19 17.28
60 INT85952 Positive_regulation of AR 168 0.67 64.36 20.66 14.88
61 INT17237 Regulation of Esr1 74 0.43 49.09 17.25 13.84
62 INT198059 Positive_regulation of CACNA1I 1 0.34 2.46 1.15 9.52
63 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
64 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42 5.00
65 INT94450 Gene_expression of Nav1 359 0.78 131.85 275.46 5.00
66 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
67 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 5.00
68 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
69 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 5.00
70 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43 5.00
71 INT1080 Negative_regulation of Ache 343 0.59 108.51 72.4 5.00
72 INT96622 Localization of Trpv1 110 0.81 59.82 63.25 5.00
73 INT1169 Negative_regulation of Bche 322 0.59 149.22 61.27 5.00
74 INT96937 Gene_expression of Mmp9 191 0.75 150.3 56.01 5.00
75 INT111051 Negative_regulation of Nav1 64 0.59 25.51 47.27 5.00
76 INT66331 Gene_expression of Cacna1a 101 0.78 49.58 46.32 5.00
77 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 5.00
78 INT25383 Gene_expression of Csf2 222 0.76 152.93 43.32 5.00
79 INT48075 Positive_regulation of Il1b 71 0.67 48.63 40.48 5.00
80 INT26698 Positive_regulation of Cacna1a 37 0.67 26.33 39.1 5.00
81 INT47939 Gene_expression of Selp 171 0.76 87.54 39.03 5.00
82 INT49214 Gene_expression of Cd4 269 0.78 154.22 34.05 5.00
83 INT62830 Gene_expression of VCAM1 149 0.78 125.23 32.4 5.00
84 INT104567 Gene_expression of Aqp1 47 0.78 44.84 28.68 5.00
85 INT73670 Gene_expression of Vcam1 128 0.78 123.79 24.96 5.00
86 INT134651 Binding of TLR4 89 0.48 66.96 23.19 5.00
87 INT109650 Gene_expression of Aqp4 87 0.78 51.52 20.72 5.00
88 INT31136 Binding of Cacna1a 28 0.45 30.76 17.35 5.00
89 INT111050 Negative_regulation of Gene_expression of Nav1 23 0.58 5.97 17.06 5.00
90 INT24225 Gene_expression of Alms1 93 0.62 52.75 16.93 5.00
91 INT9220 Gene_expression of Ighg1 125 0.77 85.74 15.92 5.00
92 INT11685 Regulation of CSF2 99 0.59 58.82 15.9 5.00
93 INT112207 Binding of Nav1 27 0.47 7.1 15.43 5.00
94 INT113606 Positive_regulation of Gene_expression of Mmp9 46 0.64 44 15.07 5.00
95 INT9191 Localization of EDN1 94 0.81 57.01 14.78 5.00
96 INT50056 Positive_regulation of Dll1 13 0.67 3.16 13.7 5.00
97 INT5207 Negative_regulation of Alms1 70 0.41 41.56 13.68 5.00
98 INT104569 Gene_expression of Aqp2 23 0.60 16.56 12.23 5.00
99 INT73829 Positive_regulation of Gene_expression of VCAM1 41 0.61 35.96 11.92 5.00
100 INT73431 Positive_regulation of Nos3 82 0.65 53.22 11.61 5.00
101 INT73959 Positive_regulation of NOSTRIN 49 0.61 31.1 11.27 5.00
102 INT75765 Positive_regulation of Gene_expression of Cacna1a 17 0.70 17.51 10.91 5.00
103 INT67048 Gene_expression of ITGA4 58 0.75 28.93 10.16 5.00
104 INT24328 Gene_expression of Egf 97 0.75 59.65 9.42 5.00
105 INT20664 Binding of ACE 60 0.48 35.27 9.16 5.00
106 INT56019 Gene_expression of Dll1 11 0.78 3.38 8.71 5.00
107 INT81444 Positive_regulation of Gene_expression of Vcam1 40 0.70 46.38 8.58 5.00
108 INT95414 Positive_regulation of Alms1 40 0.41 20.3 8.1 5.00
109 INT75932 Binding of Csf2 45 0.37 33.2 8.01 5.00
110 INT197447 Negative_regulation of Psmd1 12 0.33 4.33 7.66 5.00
111 INT327801 Positive_regulation of Gene_expression of Aqp2 6 0.44 7.67 7.24 5.00
112 INT10478 Protein_catabolism of Alms1 25 0.47 12.95 7.19 5.00
113 INT152030 Gene_expression of Postn 10 0.55 8.09 7.08 5.00
114 INT58607 Negative_regulation of Dll1 9 0.43 1.89 7.06 5.00
115 INT70287 Positive_regulation of Gene_expression of Dll1 6 0.70 3.58 6.55 5.00
116 INT39416 Gene_expression of Cd79a 81 0.64 45.17 6.08 5.00
117 INT3819 Positive_regulation of Apc 36 0.69 27.03 6.02 5.00
118 INT63042 Binding of Apoe 59 0.48 31.23 5.88 5.00
119 INT18677 Gene_expression of F3 50 0.65 30.86 5.86 5.00
120 INT123726 Positive_regulation of Notch1 23 0.70 7.2 5.65 5.00
121 INT156134 Regulation of Gene_expression of Aqp1 5 0.59 7.2 5.3 5.00
122 INT87022 Gene_expression of Apc 68 0.67 46.98 5.22 5.00
123 INT8959 Binding of Gnb5 17 0.40 31.38 5.1 5.00
124 INT10694 Binding of Bche 19 0.48 8.03 4.85 5.00
125 INT12194 Gene_expression of Trf 38 0.69 18.1 4.56 5.00
126 INT69217 Gene_expression of Notch1 20 0.78 7.8 4.41 5.00
127 INT197364 Gene_expression of MCAT 18 0.16 24.11 4.27 5.00
128 INT160023 Regulation of Aqp4 9 0.45 8.41 4.19 5.00
129 INT3817 Negative_regulation of Apc 29 0.58 22.12 3.91 5.00
130 INT184288 Localization of HMGB1 20 0.61 14.5 3.84 5.00
131 INT179542 Positive_regulation of C3 27 0.52 19.39 3.83 5.00
132 INT98624 Regulation of Aqp4 27 0.62 30.76 3.77 5.00
133 INT67726 Gene_expression of Notch1 36 0.75 9.77 3.54 5.00
134 INT104570 Localization of Aqp1 8 0.77 5.83 3.51 5.00
135 INT156132 Gene_expression of Aqp9 26 0.49 14.33 3.48 5.00
136 INT86082 Localization of Htr1b 4 0.73 2.77 3.46 5.00
137 INT131748 Binding of Csad 5 0.32 5.23 3.32 5.00
138 INT134786 Gene_expression of Adam10 17 0.68 7.61 3.29 5.00
139 INT111263 Gene_expression of Gnb5 8 0.75 8.51 3 5.00
140 INT55148 Binding of Dll1 5 0.48 0.66 2.97 5.00
141 INT184365 Negative_regulation of C3 19 0.43 13.86 2.89 5.00
142 INT139872 Regulation of Notch1 14 0.45 7.69 2.82 5.00
143 INT262476 Gene_expression of Aqp8 21 0.34 7.94 2.76 5.00
144 INT141721 Binding of Aqp1 5 0.37 1.77 2.15 5.00
145 INT50057 Regulation of Notch1 3 0.39 0.87 2.14 5.00
146 INT127777 Positive_regulation of Mthfr 4 0.38 3.8 2.09 5.00
147 INT92129 Positive_regulation of Gene_expression of F3 13 0.08 12.13 2.02 5.00
148 INT157927 Gene_expression of Scn1a 5 0.64 6.55 2.02 5.00
149 INT173512 Positive_regulation of Gene_expression of Alms1 12 0.44 8.66 1.95 5.00
150 INT216670 Negative_regulation of Postn 3 0.35 1.54 1.9 5.00
151 INT140036 Positive_regulation of Gene_expression of Notch1 6 0.61 2 1.86 5.00
152 INT184006 Gene_expression of Ighg2b 21 0.71 7.97 1.86 5.00
153 INT197360 Regulation of MCAT 6 0.09 7.86 1.78 5.00
154 INT169136 Regulation of Csad 3 0.24 2.02 1.75 5.00
155 INT97062 Binding of PML 10 0.41 11.63 1.65 5.00
156 INT194912 Regulation of Binding of Csf2 3 0.10 3.03 1.41 5.00
157 INT327824 Positive_regulation of Gene_expression of Aqp1 4 0.67 5.4 1.37 5.00
158 INT159784 Gene_expression of Mapk9 8 0.61 6.28 1.37 5.00
159 INT16239 Negative_regulation of Trf 9 0.32 4.06 1.35 5.00
160 INT99653 Gene_expression of CACNA1I 2 0.29 2.22 1.34 5.00
161 INT110784 Protein_catabolism of Notch1 8 0.21 2.32 1.31 5.00
162 INT110434 Positive_regulation of Gene_expression of Apc 20 0.50 11.37 1.3 5.00
163 INT74443 Positive_regulation of PML 11 0.53 12.52 1.21 5.00
164 INT135527 Negative_regulation of Gene_expression of Cd4 17 0.43 6.72 1.09 5.00
165 INT158542 Gene_expression of HTN1 10 0.75 10.69 1.07 5.00
166 INT171686 Binding of asp1 8 0.31 11.88 1.07 5.00
167 INT81043 Negative_regulation of Kctd1 9 0.57 7.68 1.06 5.00
168 INT67156 Binding of ITGA4 6 0.14 2.63 1.03 5.00
169 INT198062 Regulation of CACNA1I 1 0.20 2.94 1.03 5.00
170 INT235929 Regulation of Positive_regulation of Alms1 2 0.02 2.84 1.02 5.00
171 INT93244 Localization of CSAD 2 0.60 1.59 1 5.00
172 INT129425 Negative_regulation of Ldlr 22 0.42 17.15 0.97 5.00
173 INT170163 Negative_regulation of ACSM3 5 0.16 3.56 0.96 5.00
174 INT6833 Binding of Notch1 4 0.36 0.05 0.94 5.00
175 INT10827 Gene_expression of Apob 16 0.78 13.08 0.9 5.00
176 INT144273 Negative_regulation of Binding of Bche 2 0.59 2.21 0.89 5.00
177 INT137276 Binding of Acads 3 0.32 1.82 0.84 5.00
178 INT10828 Regulation of Apob 7 0.39 7.55 0.83 5.00
179 INT68247 Gene_expression of Ighg3 6 0.65 1.76 0.79 5.00
180 INT198058 Binding of CACNA1I 1 0.16 1.35 0.71 5.00
181 INT28308 Localization of SLC17A5 10 0.73 6.77 0.7 5.00
182 INT139089 Negative_regulation of Gene_expression of Dll1 2 0.43 0 0.69 5.00
183 INT140037 Positive_regulation of Positive_regulation of Notch1 2 0.22 1.34 0.69 5.00
184 INT120591 Positive_regulation of Acads 2 0.40 1.25 0.56 5.00
185 INT105722 Binding of Kctd1 4 0.35 4.4 0.43 5.00
186 INT15762 Negative_regulation of asp1 6 0.37 0.71 0.4 5.00
187 INT319970 Gene_expression of Mapk12 2 0.08 1.47 0.38 5.00
188 INT198061 Localization of MCAT 1 0.15 0.75 0.37 5.00
189 INT109613 Regulation of Kctd1 3 0.23 1.59 0.37 5.00
190 INT342161 Positive_regulation of Gene_expression of Mapk9 1 0.09 0.63 0.35 5.00
191 INT231102 Gene_expression of Mul1 8 0.21 1.66 0.35 5.00
192 INT198060 Localization of CACNA1I 1 0.37 0.71 0.32 5.00
193 INT246100 Positive_regulation of Gene_expression of Adam10 4 0.61 1.2 0.3 5.00
194 INT336951 Positive_regulation of Binding of PML 1 0.09 2.02 0.28 5.00
195 INT243208 Negative_regulation of Protein_catabolism of Alms1 2 0.06 2.21 0.26 5.00
196 INT285702 Negative_regulation of Tpmt 2 0.28 1.4 0.19 5.00
197 INT267653 Gene_expression of Kctd1 3 0.09 3.56 0.16 5.00
198 INT327863 Binding of Postn 1 0.30 1.27 0.14 5.00
199 INT327856 Gene_expression of Dlk1 1 0.45 0.97 0.13 5.00
200 INT327860 Positive_regulation of Gene_expression of Dlk1 1 0.35 1.04 0.13 5.00
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