D:Calcification

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pChart

Disease Term
Synonyms CALCIFIC, Calcification Pathologic, CALCINOSES, Calcinosis, CALCIUM DEPOSITION, Deposit Calcium, DEPOSITION OF CALCIUM, Pathologic Calcification
Documents 2530
Hot Single Events 200
Hot Interactions 61

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Calcification. They are ordered first by their relevance to Calcification and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT353861 Binding of Mgp and Phdlc1 1 0.01 5.09 0.16 100.00
2 INT225782 Tnfrsf11b Regulation of Enpp1 1 0.12 0.74 0 100.00
3 INT225802 Binding of Enpp1 and Ppi-rs 1 0.04 1 0.03 100.00
4 INT245183 Binding of CTSB and TCF7L2 1 0.39 6.39 0.18 100.00
5 INT245185 Binding of RRAD and TCF7L2 1 0.00 6.88 0.1 100.00
6 INT245182 Binding of SPINK1 and TCF7L2 1 0.39 2.05 0.1 100.00
7 INT182771 ROS1 Positive_regulation of NFKB1 Positive_regulation of CRP 1 0.00 3.83 0.28 99.76
8 INT313505 Binding of SNRNP70 and CXADRP1 1 0.00 1.15 0.1 99.72
9 INT313504 Binding of ALOX5AP and SNRNP70 1 0.04 0.5 0.05 99.72
10 INT313503 Binding of ALOX5AP and CXADRP1 1 0.01 1.51 0.08 99.44
11 INT225801 Binding of Enpp1 and Npp 1 0.17 0.46 0.04 99.40
12 INT225807 Enpp2 Positive_regulation of ALPI 1 0.00 0.23 0 99.40
13 INT225775 Enpp1 Positive_regulation of Ppi-rs 1 0.06 2.49 0.44 99.32
14 INT225776 Enpp1 Positive_regulation of Positive_regulation of Ppi-rs 1 0.08 1.67 0.28 99.32
15 INT196038 Gene_expression of Bmp7 Positive_regulation of ALPP 1 0.03 0.1 0 98.20
16 INT313499 Binding of ALOX5AP and CRP 1 0.07 0.45 0 98.04
17 INT225783 Enpp1 Regulation of Ppi-rs 1 0.07 0.68 0.13 97.56
18 INT313554 Binding of ALOX5 and Cor 1 0.02 2.47 0.17 97.36
19 INT182775 Binding of PTH and ROS1 1 0.04 1.73 0.04 97.20
20 INT225793 Ank Positive_regulation of Ppi-rs 1 0.06 1.77 0.06 96.84
21 INT182774 Binding of ETV3 and SAE1 1 0.00 1.17 0 96.60
22 INT313502 Binding of ALOX5AP and ADIPOQ 1 0.05 0.44 0 96.12
23 INT240619 Binding of CRP and ADIPOQ 8 0.18 10.74 0.78 96.08
24 INT262997 Binding of HSD11B1 and ADIPOQ 1 0.54 2.82 0.07 96.08
25 INT225792 Gene_expression of Enpp2 Positive_regulation of Ppi-rs 1 0.01 0.21 0 95.88
26 INT200637 Binding of Abpa and Ace 1 0.01 4.62 0.22 94.88
27 INT182773 ROS1 Positive_regulation of NFKB1 Positive_regulation of IL6 1 0.00 1.9 0.14 94.64
28 INT182782 NFKB1 Positive_regulation of IL6 1 0.00 1.8 0.14 94.64
29 INT225785 Enpp3 Regulation of Ppi-rs 1 0.00 0.69 0.11 94.36
30 INT182772 ROS1 Positive_regulation of NFKB1 Positive_regulation of IL1B 1 0.00 1.89 0.14 94.16
31 INT182780 NFKB1 Positive_regulation of IL1B 1 0.00 1.8 0.14 94.16
32 INT123462 Binding of TNF and Tnfrsf11b 3 0.21 3.52 0.24 93.92
33 INT168143 Tnf Positive_regulation of PLF 1 0.02 0.63 0.06 93.72
34 INT225778 Igf1 Negative_regulation of Positive_regulation of Ppi-rs 1 0.01 0.82 0.14 93.44
35 INT313498 Binding of ALOX5 and SNRNP70 1 0.05 2.7 0.21 93.20
36 INT313501 Binding of ALOX12 and ICAM1 1 0.10 0.54 0.03 92.28
37 INT313508 Binding of ALOX12 and CRP 1 0.06 0.44 0.03 92.28
38 INT313506 Binding of ICAM1 and SNRNP70 1 0.02 1.08 0.06 92.00
39 INT242037 Binding of CRP and SNRNP70 3 0.07 4.62 0.19 92.00
40 INT262994 Binding of CRP and HSD11B1 1 0.15 3.02 0.03 91.52
41 INT148580 TNF Regulation of Gene_expression of SAMD9 1 0.48 3.01 0.5 90.80
42 INT225798 Il1 Negative_regulation of Gene_expression of Ppi-rs 1 0.01 1 0.28 90.44
43 INT225796 Il1 Negative_regulation of Ppi-rs 1 0.01 1 0.28 90.44
44 INT225794 Il1 Negative_regulation of Gene_expression of Npp 1 0.02 0.99 0.28 90.44
45 INT225777 Il1 Negative_regulation of Npp 1 0.02 0.99 0.28 90.44
46 INT225784 Il1 Negative_regulation of Gene_expression of Enpp1 1 0.08 0.99 0.28 90.44
47 INT295121 Proc Regulation of Grxcr1 1 0.00 1.26 0.03 89.40
48 INT90387 ROS1 Positive_regulation of NFKB1 4 0.32 2.35 0.87 88.48
49 INT295129 Proc Regulation of Bmp2 1 0.00 0.48 0 88.20
50 INT295127 Proc Regulation of Igf1 1 0.00 0.48 0 88.20
51 INT225787 Ppi-rs Positive_regulation of Gene_expression of Ank 1 0.06 1.44 0.19 85.64
52 INT225799 Il1 Regulation of Ppi-rs 1 0.01 0.44 0.05 85.36
53 INT225806 Il1 Regulation of ALPI 1 0.00 0.44 0.05 84.64
54 INT225779 Il1 Regulation of Npp 1 0.03 0.43 0.05 84.64
55 INT225780 Il1 Regulation of Gene_expression of Npp 1 0.03 0.43 0.05 84.64
56 INT225790 Il1 Regulation of Gene_expression of Enpp1 1 0.07 0.43 0.05 84.64
57 INT313553 Binding of SNRNP70 and Cor 1 0.00 0.54 0.03 84.20
58 INT182804 Binding of ETV3 and T2DM 1 0.10 2.62 0 82.96
59 INT313500 Binding of SELE and SNRNP70 1 0.01 0.55 0.04 81.68
60 INT225781 Ppi-rs Positive_regulation of Gene_expression of Spp1 1 0.03 1 0.07 81.48
61 INT225791 Ppi-rs Positive_regulation of Spp1 1 0.02 0.49 0.04 81.48
62 INT355327 Binding of Nes and Prom1 1 0.11 1.49 0.06 79.56
63 INT189553 DCN Negative_regulation of Transcription of VEGFA 1 0.06 0.78 0.2 76.00
64 INT225805 Binding of SNRNP70 and Enpp1 1 0.42 1.43 0.09 75.88
65 INT225774 SNRNP70 Regulation of Binding of Insr and Enpp1 1 0.03 0.77 0.04 75.88
66 INT225808 SNRNP70 Regulation of Enpp1 1 0.30 0.71 0.04 75.88
67 INT304964 Binding of AMT and PTK2B 1 0.23 0.78 0.18 75.28
68 INT245194 Binding of RRAD and Abpa 1 0.00 6.29 0.13 75.00
69 INT200635 Binding of Ace and Spink1 1 0.37 1.4 0.05 75.00
70 INT153114 Binding of Abpa and Ctrc 1 0.00 1.22 0.4 75.00
71 INT153116 Binding of SPINK1 and Abpa 1 0.01 1.32 0.4 75.00
72 INT245193 Binding of TCF7L2 and Abpa 1 0.02 10.66 0 75.00
73 INT256632 Binding of PTCH1 and Jkamp 1 0.00 2.32 0 73.64
74 INT295122 Bmp2 Regulation of Grxcr1 1 0.02 0.66 0.06 72.96
75 INT295120 Bmp2 Regulation of Transcription of Pou1f1 1 0.24 0.66 0.06 72.96
76 INT348637 Binding of TLE4 and OLFM1 1 0.01 1.67 0.24 71.68
77 INT295124 Binding of Pou1f1 and Grxcr1 1 0.04 0.28 0 69.84
78 INT295130 Igf1 Regulation of Grxcr1 1 0.02 0.64 0.06 69.04
79 INT295128 Igf1 Regulation of Transcription of Pou1f1 1 0.16 0.64 0.06 69.04
80 INT225800 Binding of Insr and Enpp1 1 0.05 0.67 0.04 68.20
81 INT186685 Edn1 Regulation of Gene_expression of Il6 1 0.11 1.1 0 65.60
82 INT299041 SPARC Regulation of Gene_expression of NPEPPS 1 0.01 0.83 0.42 65.28
83 INT353865 Binding of CHI3L1 and Lepr 1 0.00 1.88 0.03 64.08
84 INT182783 INS Positive_regulation of Gene_expression of ETV3 1 0.01 1.89 0 63.48
85 INT295126 Proc Regulation of Transcription of Pou1f1 1 0.00 0.3 0.03 63.36
86 INT182784 IGF1 Positive_regulation of Gene_expression of INS 1 0.02 1.87 0 63.12
87 INT182778 IGF1 Positive_regulation of Gene_expression of ETV3 1 0.03 1.89 0 63.12
88 INT182777 IAPP Positive_regulation of Gene_expression of ETV3 1 0.06 1.88 0 62.68
89 INT182776 IAPP Positive_regulation of Gene_expression of INS 1 0.03 1.87 0 62.68
90 INT299040 Binding of COL7A1 and SPARC 1 0.02 0.7 0.42 60.80
91 INT296945 ADIPOQ Negative_regulation of TNF 1 0.03 1.13 0.4 59.24
92 INT215978 Binding of HPT and Pth 1 0.01 0.92 0 58.40
93 INT233397 Binding of ABCA4 and COL2A1 1 0.38 3.59 0.03 54.56
94 INT318132 Binding of ATRX and HBE1 1 0.00 1.47 0 54.32
95 INT307698 Binding of Crp and pad 1 0.04 3.71 0.12 53.04
96 INT225786 Enpp3 Positive_regulation of Ppi-rs 1 0.00 0.32 0.05 51.56
97 INT200640 Agtr2 Positive_regulation of Gene_expression of TGFB1 1 0.03 1.35 0.29 50.00
98 INT200639 Ace Positive_regulation of Gene_expression of TGFB1 1 0.06 1.36 0.29 50.00
99 INT200631 AGT Positive_regulation of Gene_expression of TGFB1 1 0.06 1.36 0.29 50.00
100 INT200634 Binding of Agtr2 and Ace2 1 0.00 0.91 0.06 50.00
101 INT200641 Binding of ACE and Agtr1a 1 0.12 0.92 0.06 50.00
102 INT200638 Binding of ACE and Agtr2 1 0.10 0.93 0.06 50.00
103 INT105613 Binding of Abpa and Spink1 1 0.01 0.06 0 50.00
104 INT321594 Bmp2 Regulation of Gene_expression of Lxn 1 0.42 1.71 0 48.24
105 INT333991 Binding of FLNA and SELL 1 0.00 1.69 0.55 45.96
106 INT173558 CTSK Positive_regulation of Protein_catabolism of COL5A2 1 0.00 0.53 0.22 44.32
107 INT315031 Binding of Cacna1f and Vsig2 1 0.02 0 0 39.52
108 INT196022 Bmp7 Regulation of Bmp4 1 0.06 0.06 0 36.48
109 INT283462 Binding of DLAT and HLA-DRB1 1 0.07 1.06 0.03 34.76
110 INT262996 ADIPOQ Regulation of INS 1 0.13 1.25 0.1 33.92
111 INT186355 Il23a Positive_regulation of Gene_expression of Il17a 4 0.12 3 1.24 30.96
112 INT285561 Il23a Positive_regulation of Gene_expression of Il22 2 0.06 2.45 0.93 30.96
113 INT196023 Bmp2 Negative_regulation of Gene_expression of Bmp4 1 0.09 0.07 0 26.40
114 INT295119 Negative_regulation of Binding of Pou1f1 and Slc20a2 1 0.42 0 0 22.68
115 INT295123 Binding of Pou1f1 and Slc20a2 1 0.37 0 0 22.16
116 INT189551 Binding of COL5A2 and DCN 1 0.00 0.72 0 21.36
117 INT322891 Sox9 Regulation of Transcription of Col2a1 1 0.10 0.12 0.04 21.32
118 INT196021 Bmp2 Positive_regulation of Gene_expression of Bmp4 1 0.09 0.08 0 20.20
119 INT198307 IL10 Positive_regulation of Gene_expression of IGHG3 2 0.01 1.21 0.15 14.72
120 INT250910 Thbs2 Regulation of Tgm2 1 0.04 0.3 0.13 13.36
121 INT315029 Binding of Calm3 and Cacna1f 1 0.04 0 0 12.28
122 INT315033 Binding of Calm3 and Vsig2 1 0.00 0 0 12.00
123 INT250911 Thbs2 Regulation of Mmp2 1 0.05 0.3 0.13 10.80
124 INT289878 Binding of MMD and SEPN1 1 0.16 1.27 0 9.32
125 INT95730 Binding of CP and SPINK1 2 0.19 5.65 4.02 5.00
126 INT130721 Binding of IL1B and IL1RN 6 0.05 5.29 2.85 5.00
127 INT151849 IL10 Negative_regulation of Gene_expression of IL8 4 0.14 3.26 1.54 5.00
128 INT285569 TNF Negative_regulation of Gene_expression of Il6 1 0.03 2.83 1.46 5.00
129 INT83422 Binding of FANCB and IGHG3 3 0.12 5.09 1.22 5.00
130 INT224410 Binding of CRP and CIMT 3 0.42 10.46 1.2 5.00
131 INT225067 Binding of ETF1 and IGHG3 1 0.03 4.52 1.17 5.00
132 INT267588 IL10 Negative_regulation of Gene_expression of IL6 1 0.01 2.25 1.11 5.00
133 INT267597 IL10 Negative_regulation of Gene_expression of TNF 1 0.03 2.24 1.1 5.00
134 INT243494 Binding of Vta1 and LOC308670 1 0.01 0.06 1.06 5.00
135 INT182125 Binding of CD14 and TLR4 7 0.25 3.78 1.03 5.00
136 INT54972 Binding of EDNRA and EDNRB 7 0.52 3.31 0.97 5.00
137 INT278292 Binding of CRP and ESR1 6 0.09 10.92 0.96 5.00
138 INT267630 Il1 Regulation of Gene_expression of IL8 1 0.00 0.44 0.71 5.00
139 INT285562 Binding of Il27ra and Il27 1 0.10 2.19 0.67 5.00
140 INT170832 Cftr Regulation of Scnn1a 2 0.16 1.2 0.67 5.00
141 INT185997 Binding of FANCB and fc 2 0.01 2.51 0.63 5.00
142 INT178097 Binding of EDN1 and EDNRA 7 0.21 5.97 0.62 5.00
143 INT285467 Negative_regulation of Binding of IL1B and IL1RN 1 0.05 1.33 0.61 5.00
144 INT267625 Binding of KNG1 and Klk1 2 0.21 2.23 0.61 5.00
145 INT225065 Binding of ETF1 and FANCB 1 0.01 2.07 0.59 5.00
146 INT201512 Binding of PRSS1 and hcp 1 0.09 1.9 0.57 5.00
147 INT225083 Binding of ETF1 and fc 1 0.00 2.13 0.57 5.00
148 INT173555 TIMP1 Negative_regulation of MMP7 1 0.01 0 0.56 5.00
149 INT173556 TIMP1 Negative_regulation of MMP9 1 0.02 0 0.56 5.00
150 INT173557 TIMP1 Negative_regulation of MMP3 1 0.02 0 0.56 5.00
151 INT225082 Binding of IGHG3 and fc 6 0.01 3.6 0.55 5.00
152 INT173554 TIMP1 Negative_regulation of MMP1 1 0.03 0 0.55 5.00
153 INT173553 TIMP1 Negative_regulation of MMP2 1 0.05 0 0.55 5.00
154 INT171905 TNF Positive_regulation of Gene_expression of Il1 2 0.23 1.08 0.54 5.00
155 INT173597 Negative_regulation of Binding of MMP2 and Mmp13 1 0.14 0.83 0.48 5.00
156 INT173595 Binding of MMP2 and Mmp13 1 0.12 0.83 0.48 5.00
157 INT229127 SPINK1 Positive_regulation of PRSS1 1 0.53 1.59 0.48 5.00
158 INT173596 Binding of MMP3 and Mmp13 1 0.06 0.84 0.48 5.00
159 INT173598 Negative_regulation of Binding of MMP3 and Mmp13 1 0.06 0.84 0.48 5.00
160 INT229128 Binding of CP and PRSS1 1 0.14 0.77 0.47 5.00
161 INT206538 Trem2 Regulation of Gene_expression of Cd80 1 0.17 1.26 0.44 5.00
162 INT206536 Trem2 Positive_regulation of Gene_expression of Cd80 1 0.30 1.26 0.44 5.00
163 INT303857 DDR1 Positive_regulation of IL8 1 0.05 1.5 0.42 5.00
164 INT303858 DDR1 Positive_regulation of CXCR2 1 0.11 1.5 0.42 5.00
165 INT285560 Il23a Positive_regulation of Il17a 1 0.09 1.45 0.39 5.00
166 INT285571 Binding of IL8 and Il17a 1 0.04 1.03 0.38 5.00
167 INT267585 TNF Regulation of IL6 2 0.16 2.44 0.37 5.00
168 INT267595 IL12A Positive_regulation of IFN1@ 1 0.03 0.69 0.36 5.00
169 INT285568 Binding of TNF and Tnfsf10 1 0.12 1.39 0.36 5.00
170 INT285557 Eae2 Positive_regulation of Cia1 1 0.02 1.85 0.36 5.00
171 INT285465 IL7 Positive_regulation of TNF 1 0.04 0.67 0.35 5.00
172 INT254344 Binding of Col2a1 and Ncoa5 1 0.00 0.98 0.35 5.00
173 INT352547 Binding of CFTR and DMD 1 0.01 1.42 0.35 5.00
174 INT285570 Binding of IL8 and Cdkn1c 1 0.11 0.76 0.34 5.00
175 INT267589 IL2 Positive_regulation of Gene_expression of IL12A 1 0.01 0.69 0.34 5.00
176 INT285565 Positive_regulation of Zeb1 Negative_regulation of IL2 1 0.02 0.62 0.33 5.00
177 INT174266 TNF Regulation of Gene_expression of F3 1 0.00 3.2 0.33 5.00
178 INT285558 Binding of Il11ra1 and Il27 1 0.05 1.1 0.33 5.00
179 INT285566 F8 Negative_regulation of IL2 1 0.00 0.62 0.33 5.00
180 INT333993 Binding of Vcam1 and Vwf 1 0.00 1.32 0.33 5.00
181 INT285563 Zeb1 Negative_regulation of IL2 1 0.01 0.62 0.33 5.00
182 INT174265 IL18 Regulation of Gene_expression of F3 1 0.00 3.21 0.33 5.00
183 INT223962 Tnf Negative_regulation of Gene_expression of Bglap 1 0.21 1.21 0.32 5.00
184 INT223964 Tnf Negative_regulation of Bglap 1 0.21 1.2 0.32 5.00
185 INT342457 CSF1 Negative_regulation of Gene_expression of CCR4 1 0.00 0.93 0.31 5.00
186 INT285567 Binding of IL1B and Cdc42 1 0.03 0.77 0.31 5.00
187 INT285564 Binding of IL1B and Ripk2 1 0.04 0.76 0.31 5.00
188 INT229635 SPINK5 Positive_regulation of NF1 1 0.01 2.17 0.3 5.00
189 INT335027 Binding of Vdr and Fgf23 1 0.24 0.34 0.29 5.00
190 INT185092 CRP Positive_regulation of ESR1 1 0.06 2.83 0.28 5.00
191 INT223965 Binding of AMY2A and Bglap 1 0.05 1.5 0.28 5.00
192 INT267628 IL4 Positive_regulation of IgG 1 0.00 1.42 0.27 5.00
193 INT342458 CSF1 Positive_regulation of Gene_expression of CCL2 1 0.17 0.84 0.27 5.00
194 INT267586 IL4 Positive_regulation of IGHE 1 0.00 1.42 0.27 5.00
195 INT206535 Binding of Trem2 and Tg(CAG-EGFP)D4Nagy 1 0.03 0.5 0.27 5.00
196 INT267632 Il1 Positive_regulation of Gene_expression of PLA2G6 1 0.00 0.86 0.25 5.00
197 INT267624 Klk1 Positive_regulation of KNG1 1 0.05 0.52 0.25 5.00
198 INT267584 TNF Positive_regulation of Gene_expression of PLA2G6 1 0.08 0.87 0.25 5.00
199 INT267631 IRF6 Positive_regulation of Gene_expression of Il1 1 0.00 0.96 0.25 5.00
200 INT342456 AGT Positive_regulation of Gene_expression of CCL2 1 0.07 0.63 0.25 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Calcification. They are ordered first by their pain relevance and then by number of times they were reported in Calcification. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT337100 Gene_expression of Mgp 3 0.71 45.04 1.64 100.00
2 INT262109 Positive_regulation of Mgp 2 0.63 42.44 0.9 100.00
3 INT353854 Positive_regulation of Gene_expression of Mgp 1 0.63 13.92 0.73 100.00
4 INT91544 Gene_expression of CHI3L1 60 0.75 77.72 13.9 100.00
5 INT125884 Positive_regulation of CHI3L1 15 0.62 34.04 4.43 100.00
6 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 100.00
7 INT353858 Binding of Mgp 1 0.38 7.16 0.11 100.00
8 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 100.00
9 INT170557 Gene_expression of Lepr 16 0.67 17.26 2.78 100.00
10 INT353852 Negative_regulation of Mgp 1 0.34 3 0.1 100.00
11 INT171145 Positive_regulation of Fig4 274 0.59 93.55 69.81 100.00
12 INT123459 Gene_expression of Tnfrsf11b 35 0.58 24.16 7.26 100.00
13 INT131019 Binding of T2DM 6 0.47 6.97 0.31 100.00
14 INT20936 Binding of MGP 13 0.40 3.55 3.59 100.00
15 INT353859 Positive_regulation of Binding of Mgp 1 0.37 2.89 0.04 100.00
16 INT353857 Positive_regulation of Positive_regulation of Mgp 1 0.40 2.61 0.04 100.00
17 INT353856 Regulation of Mgp 1 0.22 1.85 0.06 100.00
18 INT812 Localization of INS 1026 0.81 515.6 145.31 100.00
19 INT316779 Positive_regulation of Gene_expression of MGP 1 0.17 1.52 0.35 100.00
20 INT105021 Binding of GOPC 187 0.40 60.39 20.38 100.00
21 INT182753 Positive_regulation of Binding of 1 0.49 1.88 0 100.00
22 INT182786 Positive_regulation of Binding of ETV3 1 0.12 1.88 0 100.00
23 INT3823 Positive_regulation of ALPI 27 0.69 19.49 2.15 100.00
24 INT164464 Positive_regulation of Sec1 3 0.10 1.25 0 100.00
25 INT225760 Localization of Ank 1 0.60 0.88 0.05 100.00
26 INT17086 Binding of HSD11B1 84 0.47 122.28 6.16 100.00
27 INT8640 Positive_regulation of HSD11B1 332 0.67 377.84 22.36 100.00
28 INT281427 Positive_regulation of MGP 5 0.67 1.35 0.09 100.00
29 INT248755 Binding of SS18L1 1 0.31 5.25 0.35 100.00
30 INT180031 Gene_expression of IBGC1 1 0.05 1.38 0.2 100.00
31 INT23573 Binding of NDUFA5 3 0.47 2.12 0.21 100.00
32 INT30738 Negative_regulation of Gene_expression of ALB 32 0.59 19.01 5.04 100.00
33 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 100.00
34 INT35098 Localization of Enpp1 4 0.75 0.81 0.67 100.00
35 INT295102 Positive_regulation of Localization of Pou1f1 1 0.49 0.97 0 100.00
36 INT295096 Localization of Pou1f1 1 0.79 1.48 0 100.00
37 INT42244 Regulation of Gene_expression of PTH 5 0.45 3.95 0.34 100.00
38 INT266818 Localization of Grxcr1 7 0.12 3.9 0 100.00
39 INT34592 Positive_regulation of Gene_expression of ALPP 51 0.67 20.62 5.68 100.00
40 INT4342 Localization of ALPP 27 0.69 15.19 5.32 100.00
41 INT34593 Negative_regulation of Localization of ALPP 2 0.50 0.85 0.64 100.00
42 INT63498 Protein_catabolism of CRYGD 1 0.30 0.41 0 100.00
43 INT295083 Positive_regulation of Localization of Grxcr1 1 0.05 0.49 0 100.00
44 INT44998 Regulation of Eef1a2 6 0.42 2.37 2.65 99.96
45 INT123458 Positive_regulation of Tnfrsf11b 9 0.43 14.3 2.01 99.92
46 INT8021 Gene_expression of Enpp1 43 0.78 31.46 10.8 99.88
47 INT6512 Gene_expression of PTH 103 0.77 76.29 6.33 99.82
48 INT182791 Binding of CPLX1 1 0.04 2.85 0.3 99.82
49 INT126577 Gene_expression of Ppi-rs 25 0.14 19.1 2.74 99.80
50 INT171989 Gene_expression of Ank 8 0.78 11.76 4.36 99.80
51 INT34590 Gene_expression of ALPP 199 0.75 89.85 15.1 99.80
52 INT13396 Gene_expression of DMD 125 0.75 57.81 5.45 99.80
53 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 99.76
54 INT129762 Binding of HTN1 5 0.03 5.68 0.19 99.76
55 INT145305 Positive_regulation of Bmp2 12 0.69 8.65 0.24 99.74
56 INT151839 Positive_regulation of Bmp7 2 0.27 0.24 0 99.74
57 INT224529 Positive_regulation of Gene_expression of Enpp1 15 0.70 12.75 1.81 99.72
58 INT169180 Binding of SNRNP70 204 0.47 119.1 29.3 99.72
59 INT225757 Positive_regulation of Gene_expression of Ank 1 0.64 4.71 0.75 99.72
60 INT224530 Positive_regulation of Enpp1 12 0.70 7.03 5.82 99.70
61 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 99.66
62 INT222148 Regulation of Positive_regulation of Eef1a2 1 0.02 1.35 0.03 99.64
63 INT44997 Positive_regulation of Eef1a2 16 0.40 8.84 5.37 99.64
64 INT35527 Regulation of Binding of Eef1a2 3 0.17 1.38 0.21 99.60
65 INT30170 Gene_expression of Car2 330 0.66 77.26 46.76 99.60
66 INT23654 Binding of SPINK1 27 0.48 30.85 11.53 99.56
67 INT103378 Binding of Spink1 24 0.40 15.3 6.19 99.56
68 INT70820 Binding of CTRC 3 0.42 1.88 1.3 99.56
69 INT176519 Regulation of Gene_expression of Spp1 7 0.58 8.54 0.35 99.54
70 INT182801 Positive_regulation of CPLX1 1 0.04 2.92 0.03 99.54
71 INT97128 Localization of SPP1 32 0.80 21.75 4.02 99.52
72 INT15610 Localization of GOPC 223 0.65 68.26 28.7 99.52
73 INT182787 Binding of ETV3 14 0.37 25.44 0.37 99.46
74 INT68926 Binding of ALOX5AP 8 0.36 4.02 0.84 99.44
75 INT4551 Localization of DMRTA1 3 0.54 1.94 1.51 99.44
76 INT4552 Regulation of Localization of DMRTA1 1 0.03 0.72 0.33 99.44
77 INT88559 Negative_regulation of Spink1 25 0.56 21.81 9.28 99.44
78 INT49266 Positive_regulation of Arigg4 37 0.47 53.79 11.2 99.42
79 INT148070 Positive_regulation of Ppi-rs 14 0.08 9.46 1.67 99.40
80 INT225751 Positive_regulation of Positive_regulation of Ppi-rs 1 0.07 1.45 0.21 99.40
81 INT110427 Gene_expression of Spp1 199 0.78 176.11 23.31 99.38
82 INT136791 Negative_regulation of Spp1 24 0.59 23.6 3.33 99.38
83 INT123799 Regulation of Gene_expression of Galnt3 1 0.48 1.43 0.07 99.38
84 INT114490 Gene_expression of PDLIM7 17 0.78 11.35 1.42 99.36
85 INT189629 Negative_regulation of TIMP3 14 0.48 7.63 3.91 99.32
86 INT179644 Gene_expression of RENBP 26 0.35 13.74 1.38 99.30
87 INT172001 Gene_expression of ANKH 2 0.38 11.92 3.12 99.28
88 INT68445 Gene_expression of ENPP1 10 0.70 10.8 3.3 99.28
89 INT12915 Gene_expression of MGP 18 0.75 7.53 4.15 99.28
90 INT35526 Binding of Eef1a2 14 0.34 5.82 1.61 99.28
91 INT155833 Gene_expression of Cma1 9 0.58 15.28 2.04 99.28
92 INT225773 Regulation of Gene_expression of Ppi-rs 1 0.03 0.62 0.13 99.28
93 INT123800 Gene_expression of Galnt3 1 0.61 1.43 0.07 99.26
94 INT125477 Gene_expression of HHIP 91 0.78 31.18 12.57 99.24
95 INT182788 Gene_expression of ETV3 8 0.40 11.33 0.36 99.20
96 INT61753 Binding of HBN1 13 0.09 21.66 1.38 99.20
97 INT144490 Regulation of Gene_expression of Tnfsf11 14 0.58 14.09 2.39 99.20
98 INT207851 Regulation of Enpp1 5 0.45 4.42 2.96 99.20
99 INT65489 Regulation of Gene_expression of Crp 28 0.59 29.17 7.56 99.20
100 INT160705 Positive_regulation of Enpp3 2 0.20 1.26 0.56 99.20
101 INT37541 Gene_expression of SPP1 113 0.77 68.54 11.35 99.18
102 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 99.16
103 INT119400 Phosphorylation of Car2 19 0.52 8.47 11.63 99.16
104 INT196870 Positive_regulation of Phosphorylation of Car2 6 0.26 3.43 2.63 99.16
105 INT9945 Negative_regulation of Csf2 35 0.51 17.85 11.22 99.16
106 INT96965 Positive_regulation of PLF 4 0.49 4.37 1.45 99.16
107 INT266822 Negative_regulation of Grxcr1 10 0.10 8.12 0.17 99.16
108 INT278737 Positive_regulation of Transcription of Bmp2 1 0.47 1.4 0 99.14
109 INT132315 Positive_regulation of DLL1 6 0.67 3.4 2.45 99.14
110 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 99.12
111 INT9950 Gene_expression of OTOR 11 0.65 10.05 2.23 99.12
112 INT171964 Positive_regulation of Gene_expression of Tnfrsf11a 5 0.37 4.11 1.73 99.12
113 INT180032 Positive_regulation of CFM1 1 0.02 1.07 0.1 99.12
114 INT225771 Negative_regulation of Gene_expression of Enpp1 4 0.43 3.68 0.13 99.08
115 INT158409 Gene_expression of T2DM 3 0.65 9.58 0.56 99.08
116 INT16449 Binding of IGHG3 67 0.48 39.55 10.59 99.08
117 INT262546 Positive_regulation of Binding of Calm3 2 0.11 0.3 0.39 99.08
118 INT126576 Regulation of Ppi-rs 8 0.10 6.05 1.68 99.04
119 INT16960 Gene_expression of Crp 166 0.76 116.21 34.07 99.04
120 INT107597 Binding of Enpp1 5 0.37 3.35 2.23 98.96
121 INT55606 Binding of Ace 14 0.37 10.73 1.82 98.96
122 INT9118 Gene_expression of Ceacam1 37 0.75 17.19 6.12 98.92
123 INT128920 Gene_expression of Runx2 4 0.74 2.6 0.92 98.92
124 INT50673 Positive_regulation of Gene_expression of CPOX 156 0.54 97.31 37.03 98.88
125 INT207430 Localization of COL10A1 1 0.07 0.69 0.18 98.88
126 INT134864 Binding of Calm3 20 0.27 1.86 6.86 98.86
127 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26 98.80
128 INT96424 Transcription of Bmp2 6 0.69 6.34 1.11 98.80
129 INT148588 Positive_regulation of Protein_catabolism of SAMD9 1 0.44 0.74 0.1 98.80
130 INT148587 Protein_catabolism of SAMD9 1 0.94 0.73 0.1 98.80
131 INT180098 Regulation of Egfl7 8 0.03 5.74 0.41 98.78
132 INT225767 Negative_regulation of Ank 1 0.40 2.51 0.34 98.76
133 INT100861 Binding of CRP 179 0.48 175.2 26.45 98.76
134 INT183937 Positive_regulation of Ank 3 0.50 3.39 1.81 98.76
135 INT171998 Binding of DMD 58 0.47 38.13 3.35 98.72
136 INT126575 Negative_regulation of Ppi-rs 21 0.14 12.94 3.2 98.68
137 INT171962 Gene_expression of Tnfrsf11a 40 0.72 31.1 7.84 98.68
138 INT206518 Gene_expression of Trem2 1 0.78 16.79 6.92 98.64
139 INT96423 Gene_expression of Bmp2 61 0.78 25.07 3.01 98.60
140 INT182794 Gene_expression of CPLX1 1 0.06 5.57 0.17 98.60
141 INT163623 Localization of Galnt3 2 0.63 1.42 0 98.60
142 INT93534 Gene_expression of Tnfsf11 185 0.77 119.26 33.66 98.56
143 INT3537 Positive_regulation of Car2 413 0.56 103.51 94.35 98.56
144 INT250115 Gene_expression of Hoxb7 1 0.61 1.19 0 98.56
145 INT173801 Gene_expression of Ik 11 0.36 1.31 0.51 98.56
146 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 98.52
147 INT58288 Positive_regulation of Gene_expression of Crp 83 0.61 82.23 23.7 98.52
148 INT104207 Positive_regulation of Gene_expression of Tnfsf11 43 0.69 25.8 7.35 98.52
149 INT9694 Positive_regulation of Csf2 102 0.68 70.09 33.07 98.52
150 INT316777 Binding of LRRC26 1 0.06 2.09 0.51 98.52
151 INT93533 Positive_regulation of Tnfsf11 53 0.50 36.93 10.53 98.52
152 INT148590 Regulation of SAMD9 1 0.43 0.81 0.09 98.52
153 INT7812 Negative_regulation of SRI 10 0.59 4.28 1.46 98.52
154 INT188645 Binding of ALOX12 2 0.30 3.07 0.09 98.44
155 INT353862 Positive_regulation of Positive_regulation of CHI3L1 1 0.08 2.51 0.14 98.40
156 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 98.38
157 INT29833 Binding of Spna1 39 0.27 19.4 1.74 98.38
158 INT89484 Gene_expression of TNFRSF11B 119 0.76 53.57 19.67 98.36
159 INT50670 Gene_expression of CPOX 763 0.76 442.13 195.02 98.32
160 INT335003 Negative_regulation of Localization of Fgf23 1 0.39 2.37 0 98.32
161 INT207427 Negative_regulation of COL10A1 4 0.36 2.12 0.22 98.32
162 INT34595 Negative_regulation of Reg1 12 0.36 4.29 2.77 98.28
163 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 98.24
164 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 98.24
165 INT28872 Positive_regulation of CSRP1 49 0.70 47.23 11.7 98.20
166 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 98.20
167 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 98.16
168 INT158294 Regulation of KL 1 0.37 1.06 0.09 98.16
169 INT155889 Binding of Nps 22 0.42 9.79 2.6 98.16
170 INT111081 Gene_expression of CA1 19 0.75 51.09 26.64 98.12
171 INT311552 Positive_regulation of Gene_expression of CA1 3 0.67 21.83 11.2 98.12
172 INT10476 Binding of ALOX5 26 0.36 7.69 3.2 98.12
173 INT16428 Positive_regulation of Gtf3a 135 0.20 106.44 26.67 98.10
174 INT180163 Positive_regulation of Nfasc 49 0.40 31.96 9.41 98.10
175 INT49325 Gene_expression of Cd34 102 0.78 82.75 8.97 98.08
176 INT5841 Gene_expression of Vim 181 0.72 138.54 16.33 98.08
177 INT25123 Negative_regulation of COL7A1 42 0.58 19.98 5.96 98.08
178 INT180033 Regulation of CFM1 2 0.21 1.09 0.1 98.04
179 INT334997 Localization of Fgf23 1 0.72 3.56 0 98.00
180 INT110599 Gene_expression of Bglap 49 0.74 41.23 6.97 98.00
181 INT52297 Gene_expression of Ucma 2 0.65 1.3 0.41 97.96
182 INT158540 Negative_regulation of HTN1 4 0.34 7.25 1.22 97.92
183 INT182752 Negative_regulation of T2DM 1 0.41 2.06 0.29 97.92
184 INT200203 Regulation of Pou1f1 2 0.60 1.37 0.03 97.92
185 INT225754 Positive_regulation of Gene_expression of Ppi-rs 1 0.07 3.96 0.66 97.90
186 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 97.90
187 INT122902 Positive_regulation of Gene_expression of Spp1 54 0.70 56.3 6.33 97.90
188 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 97.90
189 INT306911 Positive_regulation of Ephx2 4 0.69 5.39 0.63 97.90
190 INT229632 Binding of PADI4 21 0.48 37.45 0.34 97.74
191 INT105199 Regulation of REG3A 1 0.60 0.75 0.06 97.72
192 INT71418 Binding of CES1 42 0.40 29.78 5.01 97.68
193 INT216454 Binding of Lif 2 0.27 0.85 0.07 97.68
194 INT221201 Binding of Ppi-rs 5 0.04 4.02 0.78 97.52
195 INT176517 Negative_regulation of Gene_expression of Spp1 18 0.59 15.31 2.28 97.52
196 INT8724 Positive_regulation of Mln 21 0.66 14.12 6.17 97.52
197 INT209753 Binding of Tro 2 0.31 1.27 0.45 97.50
198 INT6625 Negative_regulation of Pth 96 0.58 57.6 8.24 97.48
199 INT356388 Positive_regulation of Negative_regulation of Pth 1 0.21 1.91 0 97.48
200 INT161840 Gene_expression of Tnfrsf11b 17 0.78 12.44 2.63 97.44
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