D:Calculi

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pChart

Disease Term
Synonyms BILIARY URINARY STONES, Calculus
Documents 1017
Hot Single Events 46
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Calculi. They are ordered first by their relevance to Calculi and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT197467 Binding of Dpcd and Memor1 1 0.00 0.12 0 57.96
2 INT86179 TNF Positive_regulation of Localization of IL6 5 0.35 1.66 2.17 5.00
3 INT197470 Binding of Sostdc1 and Hbtq 1 0.00 0.87 0.87 5.00
4 INT292893 TNF Regulation of IL8 2 0.27 1.3 0.63 5.00
5 INT267585 TNF Regulation of IL6 2 0.16 2.44 0.37 5.00
6 INT311264 IL6 Positive_regulation of Gene_expression of PPIAP10 1 0.30 0.98 0.36 5.00
7 INT236955 Binding of Cxcr5 and Cxcl13 1 0.28 2.26 0.34 5.00
8 INT311265 RENBP Regulation of IL8 1 0.03 1.59 0.33 5.00
9 INT311263 RENBP Regulation of TNF 1 0.01 1.59 0.33 5.00
10 INT311266 RENBP Regulation of IL6 1 0.02 1.59 0.32 5.00
11 INT311268 RENBP Regulation of Gene_expression of IL8 1 0.02 1.05 0.24 5.00
12 INT252646 Binding of C6orf25 and SYT16 1 0.00 0.51 0.17 5.00
13 INT311262 RENBP Regulation of Regulation of TNF 1 0.02 0.33 0.13 5.00
14 INT311267 RENBP Regulation of Gene_expression of TNF 1 0.02 0.54 0.09 5.00
15 INT308225 Alb Positive_regulation of Binding of EIF4G2 1 0.02 0.33 0.09 5.00
16 INT339897 Binding of Bnc1 and Shc4 1 0.05 0.69 0.07 5.00
17 INT197466 Dpcd Positive_regulation of Sostdc1 1 0.00 0 0 5.00
18 INT197469 Binding of Dpcd and Hbtq 1 0.00 0 0 5.00
19 INT197468 Dpcd Positive_regulation of Hbtq 1 0.00 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Calculi. They are ordered first by their pain relevance and then by number of times they were reported in Calculi. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT1168 Binding of PROC 62 0.38 44.15 9.04 100.00
2 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18 99.92
3 INT241081 Localization of PUJO 1 0.60 0.52 0.03 99.92
4 INT23146 Negative_regulation of Aprt 8 0.56 7.53 0.71 99.76
5 INT75485 Gene_expression of Tgfbr2 10 0.57 10.98 3.76 98.68
6 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 98.60
7 INT9910 Protein_catabolism of CXCL1 1 0.02 1.18 0.44 98.58
8 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77 98.24
9 INT74446 Positive_regulation of Dync1h1 25 0.59 13 2.38 97.52
10 INT153300 Negative_regulation of Gene_expression of CRP 48 0.58 39.97 7.58 97.44
11 INT172924 Gene_expression of BOP 8 0.47 3.15 0.14 96.88
12 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 96.56
13 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 96.56
14 INT34595 Negative_regulation of Reg1 12 0.36 4.29 2.77 96.44
15 INT278590 Gene_expression of Eci1 1 0.07 0.39 0.03 96.04
16 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 95.84
17 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 95.36
18 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 95.26
19 INT87939 Gene_expression of P2RX3 23 0.75 6.15 6.62 95.08
20 INT42810 Gene_expression of CALCRL 53 0.77 10.87 15.42 95.08
21 INT28229 Gene_expression of DLG2-AS1 1 0.11 0.3 0.16 93.20
22 INT278594 Binding of BOP 5 0.29 2.01 0.17 93.12
23 INT278595 Regulation of Binding of BOP 1 0.27 0.33 0.05 93.12
24 INT251 Regulation of INS 398 0.62 232.47 55.04 93.04
25 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 92.80
26 INT15777 Gene_expression of Pvalb 66 0.78 25.97 26.13 92.44
27 INT36260 Negative_regulation of Localization of Reg1 1 0.43 0.69 0.21 92.40
28 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 92.36
29 INT32145 Localization of Reg1 7 0.73 3.2 1.7 91.88
30 INT59175 Localization of TNMD 4 0.70 4.14 0.71 90.00
31 INT278596 Localization of BOP 1 0.45 1.15 0.24 89.16
32 INT197459 Gene_expression of Sostdc1 10 0.01 1.04 4.11 88.84
33 INT45971 Negative_regulation of GOT1 9 0.51 6.2 2.84 88.64
34 INT138457 Gene_expression of Hbtq 13 0.02 1.68 2 88.28
35 INT32203 Negative_regulation of Crp 48 0.58 32.77 11.89 87.72
36 INT118217 Regulation of Cuzd1 2 0.30 2.36 0.91 86.92
37 INT18515 Gene_expression of Lipg 18 0.66 9.3 3.72 86.48
38 INT212876 Negative_regulation of Gene_expression of Lipg 1 0.06 0.37 0.1 86.48
39 INT33008 Gene_expression of Dync1h1 41 0.68 23.85 3.82 86.40
40 INT17562 Negative_regulation of Lipg 32 0.51 16.91 3.17 85.92
41 INT45253 Positive_regulation of Ltf 20 0.69 10.22 2.77 84.28
42 INT60407 Regulation of Reg1 1 0.09 0.77 0.1 84.04
43 INT127046 Gene_expression of P2RX7 65 0.78 34.28 14.76 83.08
44 INT2116 Negative_regulation of VSX1 29 0.36 10.67 1.89 82.56
45 INT38671 Positive_regulation of KRT20 62 0.53 40.17 5.6 82.08
46 INT88009 Gene_expression of ARTN 4 0.75 2.28 1.9 80.56
47 INT122860 Negative_regulation of HGD 3 0.57 2.03 0.42 78.72
48 INT36698 Binding of CHRM3 5 0.48 1.97 1.49 78.56
49 INT38673 Negative_regulation of KRT20 38 0.42 22.49 2.77 77.72
50 INT4860 Positive_regulation of CALCA 148 0.00 73.35 97.61 76.48
51 INT17715 Positive_regulation of CELA1 8 0.61 3.76 1 75.00
52 INT12240 Negative_regulation of PRSS1 46 0.57 29.5 10.77 75.00
53 INT36449 Negative_regulation of G6PD 74 0.59 54.15 8.85 73.88
54 INT36450 Regulation of Negative_regulation of G6PD 2 0.40 1.59 0.46 71.44
55 INT82918 Binding of AMBP 23 0.39 23.31 1.71 70.52
56 INT285 Positive_regulation of Salpa1 73 0.68 61.47 9.19 67.76
57 INT185095 Negative_regulation of Binding of Uso1 1 0.19 0.32 0 67.12
58 INT65642 Binding of Dync1h1 27 0.41 15.83 2.68 66.84
59 INT185096 Binding of Uso1 1 0.17 0.32 0 66.68
60 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 65.68
61 INT218235 Negative_regulation of Gene_expression of Dync1h1 2 0.37 0.57 0.34 65.24
62 INT89661 Gene_expression of Hrec 102 0.21 69.91 39.57 64.24
63 INT95475 Positive_regulation of P2RX3 13 0.67 6.28 5.82 63.16
64 INT2244 Positive_regulation of Localization of GAST 7 0.68 5.28 0.73 62.52
65 INT22782 Localization of PRSS1 25 0.81 14.44 7.34 61.96
66 INT2243 Localization of GAST 67 0.81 34.54 16.19 61.48
67 INT212042 Gene_expression of SCYL1 2 0.09 5.78 1.38 61.20
68 INT110569 Gene_expression of XDH 31 0.75 18.35 1.34 59.44
69 INT2604 Positive_regulation of Got1 223 0.70 154.78 49.51 58.88
70 INT3892 Positive_regulation of XDH 8 0.67 8.57 1.5 55.16
71 INT22095 Negative_regulation of Dync1h1 11 0.48 5.17 1.08 54.72
72 INT88726 Gene_expression of HPRT1 36 0.78 10.12 1.58 51.32
73 INT170444 Binding of Gopc 172 0.39 45.05 20.71 50.96
74 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 48.08
75 INT87938 Regulation of P2RX3 5 0.43 2.37 2.32 47.76
76 INT92486 Positive_regulation of Gene_expression of P2RX3 5 0.49 1.56 1.82 45.24
77 INT182810 Gene_expression of Cuzd1 5 0.44 1.49 0.53 43.84
78 INT38672 Binding of KRT20 69 0.39 48.01 6.31 42.24
79 INT278591 Localization of Eci1 1 0.09 0 0 41.24
80 INT346862 Regulation of Binding of Dync1h1 1 0.39 0.16 0.34 37.16
81 INT14480 Positive_regulation of RIT1 5 0.67 1.95 1 37.12
82 INT212041 Binding of ADAM11 2 0.35 6.32 0.34 33.92
83 INT182806 Binding of Cuzd1 3 0.24 1.45 0.53 33.52
84 INT180034 Transcription of Large 1 0.57 0.42 1.22 33.20
85 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35 32.92
86 INT138458 Binding of Hbtq 4 0.01 0.32 0.22 29.20
87 INT161812 Positive_regulation of PER1 17 0.56 5.64 2.93 29.04
88 INT140394 Regulation of Dync1h1 7 0.39 2.59 1.25 27.20
89 INT299483 Binding of MIR920 1 0.03 0.18 0.03 24.72
90 INT299482 Binding of ZNF430 1 0.02 0.18 0.03 24.24
91 INT132853 Gene_expression of GCFC2 2 0.58 1.06 0.41 23.88
92 INT10797 Binding of CYP2D6 86 0.48 15.09 31.16 23.76
93 INT299481 Binding of MIR640 1 0.03 0.18 0.03 23.28
94 INT711 Positive_regulation of PIK3C2A 83 0.70 76.87 13.18 21.52
95 INT4435 Gene_expression of PIK3C2A 20 0.77 14.43 2.48 21.52
96 INT1940 Localization of PIK3C2A 8 0.78 7.28 1.01 21.52
97 INT11709 Positive_regulation of Gene_expression of PIK3C2A 2 0.49 1.88 0.74 21.52
98 INT254654 Positive_regulation of Localization of PIK3C2A 1 0.49 0.84 0.25 21.52
99 INT138594 Gene_expression of COP 10 0.57 1.33 0.98 21.40
100 INT278589 Binding of Eci1 1 0.04 0 0 19.88
101 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 18.28
102 INT132392 Negative_regulation of UOX 3 0.43 1.37 0.13 15.72
103 INT194532 Positive_regulation of UOX 3 0.35 0.78 0.03 15.72
104 INT48418 Localization of Dync1h1 4 0.61 1.54 0.44 9.92
105 INT278593 Regulation of BOP 1 0.16 0.08 0 6.72
106 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
107 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
108 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
109 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
110 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
111 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
112 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
113 INT22548 Positive_regulation of Casp3 483 0.70 258.78 213.07 5.00
114 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58 5.00
115 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
116 INT1114 Localization of Ins1 748 0.80 192.95 165.48 5.00
117 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
118 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
119 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
120 INT48895 Gene_expression of Il10 333 0.78 221.2 138.52 5.00
121 INT252 Localization of GH1 529 0.80 227.4 122.05 5.00
122 INT14151 Gene_expression of Casp3 311 0.78 140.26 120.68 5.00
123 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 5.00
124 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
125 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
126 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
127 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 5.00
128 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43 5.00
129 INT9382 Regulation of TRPV1 149 0.62 53.99 77.46 5.00
130 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 5.00
131 INT7134 Localization of KNG1 127 0.79 65.73 67.97 5.00
132 INT253 Regulation of PRL 184 0.62 47.27 65.79 5.00
133 INT39153 Positive_regulation of PTGS2 182 0.70 96.16 60.6 5.00
134 INT9196 Gene_expression of PTGS1 215 0.77 96.99 60.5 5.00
135 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
136 INT55344 Gene_expression of Ros1 396 0.54 217.64 59.98 5.00
137 INT6477 Gene_expression of IL1RN 213 0.77 114.69 58.62 5.00
138 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 5.00
139 INT48891 Positive_regulation of Il10 143 0.70 101.42 56.72 5.00
140 INT69876 Negative_regulation of Nfkb1 147 0.58 89.81 55.5 5.00
141 INT921 Regulation of GH1 172 0.60 52.88 51.04 5.00
142 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 5.00
143 INT531 Gene_expression of GH1 376 0.75 193.45 46.24 5.00
144 INT2275 Negative_regulation of Localization of Ins1 183 0.59 51.02 44.94 5.00
145 INT27493 Negative_regulation of Casp3 114 0.56 56.89 44.63 5.00
146 INT85943 Negative_regulation of Nos2 161 0.59 108.56 42.65 5.00
147 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 5.00
148 INT65889 Gene_expression of RETNLB 73 0.34 60.98 38.3 5.00
149 INT3971 Positive_regulation of Alb 175 0.70 98.46 36.45 5.00
150 INT48896 Positive_regulation of Gene_expression of Il10 73 0.70 43.14 35.5 5.00
151 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 5.00
152 INT6484 Binding of IL1B 122 0.47 75.84 35.07 5.00
153 INT985 Negative_regulation of GH1 213 0.57 89.53 32.39 5.00
154 INT724 Negative_regulation of Alb 151 0.59 93.57 29.65 5.00
155 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
156 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 5.00
157 INT100861 Binding of CRP 179 0.48 175.2 26.45 5.00
158 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 5.00
159 INT61664 Regulation of GRIN1 38 0.60 16.45 25.35 5.00
160 INT10836 Negative_regulation of IL8 95 0.59 52.59 24.71 5.00
161 INT63419 Gene_expression of PTGES 109 0.77 40.83 23.67 5.00
162 INT956 Negative_regulation of PRL 94 0.59 42.72 23.01 5.00
163 INT72060 Positive_regulation of Gene_expression of Ros1 127 0.41 76.76 20.91 5.00
164 INT74286 Regulation of Il10 42 0.44 28.06 19.44 5.00
165 INT16445 Gene_expression of IL1A 60 0.78 44.46 19.19 5.00
166 INT56749 Gene_expression of PCNA 219 0.77 111.25 18.42 5.00
167 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 5.00
168 INT1060 Negative_regulation of Pla2g1b 50 0.57 22.91 18.12 5.00
169 INT10834 Binding of IL8 65 0.48 41.66 16.53 5.00
170 INT73916 Gene_expression of Esr1 58 0.77 26.59 15.15 5.00
171 INT13752 Binding of Scn4a 24 0.36 5.68 14.16 5.00
172 INT59870 Gene_expression of F3 51 0.65 51.83 14.01 5.00
173 INT39733 Localization of NFKB1 59 0.79 22.76 13.99 5.00
174 INT18773 Localization of ALB 117 0.80 69.18 13.8 5.00
175 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61 5.00
176 INT49266 Positive_regulation of Arigg4 37 0.47 53.79 11.2 5.00
177 INT5464 Regulation of CALCRL 24 0.16 4.2 11.19 5.00
178 INT178306 Negative_regulation of Gene_expression of Gopc 71 0.37 26.43 9.74 5.00
179 INT1224 Gene_expression of Fabp6 34 0.64 23.69 9.08 5.00
180 INT57549 Gene_expression of GNPTAB 49 0.65 57.5 9.05 5.00
181 INT75907 Binding of LEP 53 0.46 46.65 8.44 5.00
182 INT98178 Localization of Casp3 32 0.65 21.01 7.77 5.00
183 INT19475 Positive_regulation of IL1A 20 0.67 17.99 7.57 5.00
184 INT103289 Binding of Il10 15 0.35 13.67 7.42 5.00
185 INT91906 Regulation of Gene_expression of Il10 13 0.58 8.92 7.06 5.00
186 INT57232 Binding of Casp3 22 0.36 9.42 6.2 5.00
187 INT20280 Positive_regulation of Esr1 32 0.69 18.37 5.69 5.00
188 INT125467 Positive_regulation of Gene_expression of CDKN2A 35 0.63 39.07 5.56 5.00
189 INT28088 Binding of Alb 34 0.47 11.06 5.48 5.00
190 INT91754 Gene_expression of Cp 42 0.77 21.97 5.38 5.00
191 INT197458 Positive_regulation of Sostdc1 11 0.01 3.02 4.87 5.00
192 INT57274 Positive_regulation of Gene_expression of COL7A1 50 0.69 24.19 4.72 5.00
193 INT76884 Positive_regulation of Cp 22 0.69 12.84 4.6 5.00
194 INT59083 Positive_regulation of Gene_expression of IL1A 11 0.70 9.09 4.48 5.00
195 INT28030 Binding of Otc 5 0.37 2.72 4.3 5.00
196 INT20230 Negative_regulation of Positive_regulation of Alb 15 0.56 12.44 4.11 5.00
197 INT156137 Gene_expression of Col1a2 28 0.73 13.3 3.99 5.00
198 INT181347 Gene_expression of Cxcl13 9 0.63 9.08 3.75 5.00
199 INT72798 Binding of ADA 12 0.47 7.84 3.39 5.00
200 INT343990 Negative_regulation of UQCRC2 1 0.17 9.55 3.28 5.00
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