D:Canker Sores

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Disease Term
Synonyms Aphthae, Aphthous Stomatitides, Aphthous Stomatitis, APHTHOUS ULCER, Aphthous Ulcers, Canker Sore, Periadenitis Mucosa Necrotica Recurrens, Sore Canker, Sores Canker, Stomatitides Aphthous, Stomatitis Aphthous
Documents 271
Hot Single Events 36
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Canker Sores. They are ordered first by their relevance to Canker Sores and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT185379 Binding of IRF6 and TLR2 4 0.08 2.88 0.35 57.36
2 INT185385 Binding of TLR2 and TLR4 3 0.27 3.63 0.32 57.36
3 INT182124 Binding of IRF6 and TLR4 14 0.10 16.11 4.65 57.00
4 INT333476 IL12B Positive_regulation of Localization of AFP 1 0.03 0.26 0.57 50.00
5 INT333477 CXCL10 Positive_regulation of TH1L 1 0.14 0.32 0.56 50.00
6 INT174657 IL8 Positive_regulation of Gene_expression of LTBR 1 0.01 1.53 0.3 28.00
7 INT174659 TNF Positive_regulation of Gene_expression of LTBR 1 0.22 1.54 0.3 28.00
8 INT174658 TNF Positive_regulation of Gene_expression of ITGAM 1 0.16 1.54 0.3 27.60
9 INT149117 Binding of CD80 and CTLA4 31 0.52 12.7 7.73 5.00
10 INT155484 Binding of CD86 and CTLA4 15 0.52 8.85 6.09 5.00
11 INT194647 Binding of CD28 and CD80 15 0.40 4.9 3.22 5.00
12 INT194646 Binding of CD28 and CD86 7 0.40 2.69 2.21 5.00
13 INT231769 TNF Negative_regulation of Gene_expression of HMOX1 1 0.26 4.75 1.15 5.00
14 INT205120 Binding of CD4 and CD8A 3 0.15 2.83 0.72 5.00
15 INT231763 Binding of HSPD1 and TLR2 1 0.12 2 0.19 5.00
16 INT293361 Binding of CD80 and KLRD1 1 0.00 0.38 0.16 5.00
17 INT231765 Binding of HSPD1 and TLR4 1 0.13 1.94 0.16 5.00
18 INT293359 Binding of CD86 and KLRD1 1 0.00 0.38 0.16 5.00
19 INT231757 TLR4 Positive_regulation of Negative_regulation of HMOX1 1 0.26 1.37 0.15 5.00
20 INT231761 TNF Negative_regulation of HMOX1 1 0.19 1.2 0.12 5.00
21 INT293312 CTLA4 Negative_regulation of Binding of CD28 and CD80 1 0.01 0.29 0.12 5.00
22 INT231767 Positive_regulation of CD14 Positive_regulation of Binding of IRF6 1 0.04 1.6 0.11 5.00
23 INT231770 CD14 Positive_regulation of Binding of IRF6 1 0.04 1.59 0.11 5.00
24 INT231755 CD14 Positive_regulation of Binding of IRF6 and TLR4 1 0.03 1.6 0.11 5.00
25 INT231756 Positive_regulation of TLR4 Positive_regulation of Binding of HMOX1 and TLR4 1 0.25 0.96 0.11 5.00
26 INT231764 TLR4 Negative_regulation of HMOX1 1 0.27 1.54 0.11 5.00
27 INT231768 Binding of HMOX1 and TLR4 1 0.23 0.95 0.11 5.00
28 INT231772 TNF Positive_regulation of Gene_expression of HMOX1 1 0.21 0.96 0.1 5.00
29 INT231773 IRF6 Negative_regulation of Gene_expression of HMOX1 1 0.06 1.27 0.09 5.00
30 INT336341 Binding of RTCA and ELOVL1 1 0.02 2.15 0.07 5.00
31 INT231760 TNF Positive_regulation of Protein_catabolism of HMOX1 1 0.31 0.41 0.06 5.00
32 INT231758 IRF6 Regulation of Gene_expression of HMOX1 1 0.08 0.23 0.05 5.00
33 INT293360 Binding of CSH1 and FKBP1A 1 0.00 0.14 0.05 5.00
34 INT231766 TLR4 Negative_regulation of Gene_expression of HMOX1 1 0.28 0.71 0.05 5.00
35 INT231759 IL10 Positive_regulation of Gene_expression of HMOX1 1 0.06 0.7 0.04 5.00
36 INT293353 Binding of CD8A and Cd3e 1 0.01 0.07 0.04 5.00
37 INT231775 TLR4 Regulation of Gene_expression of HMOX1 1 0.29 0.68 0.04 5.00
38 INT231771 Binding of HMOX1 and TNF 2 0.14 1.41 0.04 5.00
39 INT231774 Gene_expression of TLR4 Positive_regulation of Gene_expression of HMOX1 1 0.30 0.68 0.04 5.00
40 INT231762 TLR4 Positive_regulation of Gene_expression of HMOX1 1 0.30 0.68 0.04 5.00
41 INT293367 Binding of CABIN1 and Ppia 1 0.00 0.19 0.03 5.00
42 INT293358 Binding of FKBP1A and CABIN1 1 0.00 0.07 0.03 5.00
43 INT293368 Binding of CSH1 and Ppia 1 0.00 0.19 0.03 5.00
44 INT293355 Binding of Fkbp1a and CABIN1 1 0.00 0.12 0 5.00
45 INT293357 RORC Regulation of PPP2R4 1 0.00 0 0 5.00
46 INT293354 Binding of CSH1 and Fkbp1a 1 0.00 0.12 0 5.00
47 INT293366 Binding of CABIN1 and Fkbp1a 1 0.00 0.05 0 5.00
48 INT248765 Binding of RUNX1 and CSF2 1 0.02 1.36 0 5.00
49 INT293362 CSH1 Negative_regulation of Gene_expression of IL2 1 0.01 0.12 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Canker Sores. They are ordered first by their pain relevance and then by number of times they were reported in Canker Sores. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT22080 Regulation of ras 40 0.53 36.24 4.44 100.00
2 INT81688 Binding of ras 32 0.41 30.13 4.02 100.00
3 INT33220 Negative_regulation of ras 110 0.58 70.21 9.19 100.00
4 INT16205 Localization of ras 25 0.73 18.99 1.85 100.00
5 INT21685 Gene_expression of ras 115 0.66 85.6 7.76 100.00
6 INT21687 Positive_regulation of ras 143 0.58 97.34 27.31 100.00
7 INT36162 Phosphorylation of ras 5 0.70 3.87 0.72 100.00
8 INT168624 Regulation of Gene_expression of ras 7 0.39 6.49 0.08 100.00
9 INT293722 Positive_regulation of Binding of ras 2 0.49 2.19 0.05 100.00
10 INT21609 Positive_regulation of RASGRP1 58 0.50 40.78 5.47 100.00
11 INT83581 Positive_regulation of Localization of ras 5 0.49 3.07 0.56 100.00
12 INT44293 Regulation of TP63 6 0.24 2.88 0.76 100.00
13 INT12844 Binding of TP63 15 0.47 10.57 3.38 100.00
14 INT141900 Regulation of VDI 1 0.00 0.92 0.19 100.00
15 INT48235 Negative_regulation of NPEPPS 72 0.46 44.54 25.03 99.84
16 INT155857 Regulation of Negative_regulation of NPEPPS 1 0.04 0.54 0.39 99.84
17 INT48895 Gene_expression of Il10 333 0.78 221.2 138.52 99.80
18 INT19396 Regulation of Rac1 66 0.53 37.41 30.01 99.46
19 INT43721 Gene_expression of Vegfa 49 0.77 36.18 6.63 99.00
20 INT1221 Regulation of SGCG 65 0.60 24.21 22.94 98.76
21 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 98.28
22 INT23402 Binding of HLA-DOA 74 0.48 52.01 10.89 97.72
23 INT150422 Positive_regulation of Aes 24 0.43 15.63 8 96.00
24 INT105677 Binding of Vegfa 7 0.37 5.22 0.51 94.36
25 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 92.28
26 INT701 Localization of IGHE 87 0.80 40.5 10.62 91.84
27 INT67104 Localization of FCGR3A 3 0.64 1.93 0.14 91.84
28 INT170662 Localization of NPCDR1 1 0.37 1.14 0 90.80
29 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 90.28
30 INT14778 Gene_expression of FCGR3A 25 0.75 16.25 3.86 88.08
31 INT130344 Gene_expression of APOH 3 0.34 2.87 0.32 88.08
32 INT17417 Positive_regulation of Ighd 16 0.69 24.29 2.8 87.88
33 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 86.24
34 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 85.00
35 INT130431 Gene_expression of DNASE1 4 0.60 1.42 0.13 82.40
36 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 80.68
37 INT86437 Binding of IL6 154 0.48 121.22 29.3 79.68
38 INT333489 Negative_regulation of PRSS21 1 0.01 2.7 0.36 79.60
39 INT9210 Regulation of IL6 166 0.62 125.61 49.95 78.96
40 INT19399 Gene_expression of Rf 43 0.36 33.39 13.53 77.88
41 INT8063 Regulation of RASGRP1 15 0.36 9.15 1.3 75.00
42 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 75.00
43 INT5650 Gene_expression of Mpo 117 0.77 80.27 26.42 74.96
44 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 73.52
45 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 73.52
46 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 73.52
47 INT19929 Negative_regulation of Positive_regulation of TNF 52 0.59 38.16 16.51 73.52
48 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 73.48
49 INT16996 Gene_expression of PRTN3 113 0.75 85.61 22.57 72.64
50 INT16997 Binding of PRTN3 34 0.48 33.44 6.45 69.20
51 INT57958 Positive_regulation of Myo5a 9 0.41 7.52 0.77 67.24
52 INT54701 Localization of Ptafr 19 0.49 18.68 3.82 65.76
53 INT7205 Positive_regulation of HBG1 65 0.69 40.35 6.37 65.48
54 INT192783 Phosphorylation of Myo5a 1 0.04 2.01 0.12 65.48
55 INT134651 Binding of TLR4 89 0.48 66.96 23.19 65.12
56 INT117223 Gene_expression of TLR4 348 0.78 206.18 54.42 65.12
57 INT151939 Gene_expression of NPCDR1 4 0.65 1.65 0 64.08
58 INT88070 Binding of Ema 7 0.18 7.39 0.31 63.60
59 INT66423 Binding of ELOVL1 52 0.40 61.63 5.16 62.72
60 INT129934 Gene_expression of G6PC 3 0.57 5.3 0.35 62.32
61 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 60.40
62 INT45975 Positive_regulation of SAA1 17 0.67 19.7 4.15 60.40
63 INT167964 Gene_expression of Aes 30 0.58 25.41 10.16 57.84
64 INT150540 Binding of TLR2 50 0.45 35.86 10.43 57.36
65 INT2036 Localization of EGF 42 0.77 21.5 9.74 53.84
66 INT27881 Binding of HSPD1 10 0.31 9.2 1.78 52.80
67 INT84701 Binding of HSP90B2P 8 0.47 7.37 1.29 52.80
68 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 50.00
69 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 50.00
70 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 50.00
71 INT46637 Gene_expression of CXCL10 172 0.78 121.94 57.74 50.00
72 INT145266 Gene_expression of IL17A 154 0.75 109.83 45.33 50.00
73 INT72651 Gene_expression of TH1L 114 0.75 80.15 35.15 50.00
74 INT52722 Localization of RETNLB 54 0.38 48.63 27.98 50.00
75 INT100861 Binding of CRP 179 0.48 175.2 26.45 50.00
76 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 50.00
77 INT94335 Positive_regulation of CXCL10 71 0.58 50.69 23 50.00
78 INT19330 Binding of HLA-A 99 0.48 76.26 22.85 50.00
79 INT170335 Gene_expression of INCENP 176 0.54 91.62 15.31 50.00
80 INT75540 Positive_regulation of TH1L 62 0.67 43.45 15.02 50.00
81 INT10709 Negative_regulation of CD4 106 0.59 95.6 14.89 50.00
82 INT137181 Gene_expression of CXCL9 25 0.65 13.09 9.56 50.00
83 INT6510 Gene_expression of AFP 130 0.78 119.2 9.19 50.00
84 INT25152 Gene_expression of SAA1 37 0.75 53.56 8.07 50.00
85 INT92234 Regulation of CXCL10 15 0.42 8.37 5.09 50.00
86 INT11298 Gene_expression of Ido1 6 0.58 6.71 4.85 50.00
87 INT25464 Binding of SAA1 11 0.42 6.89 3.72 50.00
88 INT174477 Negative_regulation of IL7 11 0.47 10.35 3.69 50.00
89 INT155011 Negative_regulation of IL17A 8 0.54 6.43 3.64 50.00
90 INT176386 Positive_regulation of Gene_expression of TH1L 14 0.32 9.17 3.4 50.00
91 INT8477 Negative_regulation of AFP 35 0.58 31.52 3.1 50.00
92 INT92648 Positive_regulation of IL12B 7 0.20 4.55 2.19 50.00
93 INT226492 Negative_regulation of IL13 11 0.28 7.17 2.04 50.00
94 INT24453 Binding of NLRP3 18 0.48 13.7 1.93 50.00
95 INT150248 Positive_regulation of Gene_expression of Ido1 2 0.43 2.68 1.77 50.00
96 INT322198 Positive_regulation of AMCN 13 0.43 7.79 1.73 50.00
97 INT164152 Negative_regulation of PSMD2 9 0.37 3.41 1.56 50.00
98 INT43019 Regulation of PHGDH 4 0.26 2.46 1.53 50.00
99 INT160606 Localization of AFP 6 0.74 3.39 1.29 50.00
100 INT226444 Negative_regulation of CCL11 3 0.41 2.32 1.12 50.00
101 INT192761 Positive_regulation of Gene_expression of SAA1 5 0.40 7.45 0.82 50.00
102 INT150251 Transcription of FOXP3 7 0.61 0.43 0.76 50.00
103 INT24029 Regulation of AFP 7 0.44 6.45 0.51 50.00
104 INT333486 Negative_regulation of SPAG17 1 0.00 0.65 0.47 50.00
105 INT61611 Positive_regulation of ANC 17 0.41 4.43 0.31 50.00
106 INT194049 Positive_regulation of Binding of CRP 3 0.48 4.48 0.24 50.00
107 INT150252 Negative_regulation of IL2RA 3 0.41 1.73 0.23 50.00
108 INT333490 Localization of PRSS21 1 0.02 4.07 0.16 50.00
109 INT191794 Positive_regulation of ALLC 3 0.11 2.16 0.16 50.00
110 INT333485 Transcription of PRSS21 1 0.01 3.57 0.15 50.00
111 INT150253 Positive_regulation of Transcription of FOXP3 2 0.39 0 0.15 50.00
112 INT333484 Negative_regulation of ALLC 1 0.11 0.71 0.15 50.00
113 INT150250 Transcription of IDO1 2 0.69 0.08 0.09 50.00
114 INT333488 Positive_regulation of Positive_regulation of AMCN 1 0.25 1.14 0.04 50.00
115 INT333492 Positive_regulation of Positive_regulation of ANC 1 0.19 1.14 0.04 50.00
116 INT333491 Positive_regulation of Binding of SAA1 1 0.29 1.05 0.04 50.00
117 INT150246 Negative_regulation of Gene_expression of Ido1 1 0.07 0 0 50.00
118 INT150247 Transcription of Ido1 1 0.10 0 0 50.00
119 INT150249 Negative_regulation of Transcription of Ido1 1 0.08 0 0 50.00
120 INT157950 Negative_regulation of Regulation of ras 1 0.15 0 0 50.00
121 INT117204 Gene_expression of Tcm 39 0.58 10.58 4.88 49.68
122 INT102658 Negative_regulation of Gene_expression of CSF2 42 0.50 38.63 8.32 45.64
123 INT160251 Gene_expression of Myo5a 48 0.63 37.14 3.16 41.48
124 INT160258 Negative_regulation of Myo5a 3 0.35 3.96 0.09 41.48
125 INT192791 Negative_regulation of MVK 3 0.16 5.64 0.25 39.64
126 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 38.48
127 INT192071 Gene_expression of Carg1 10 0.13 9.4 0.36 37.32
128 INT154768 Negative_regulation of ATM 10 0.57 7.05 0.39 36.20
129 INT14572 Binding of INS 205 0.48 175.43 13.38 34.00
130 INT27230 Gene_expression of LTBR 10 0.75 8.57 2.34 28.00
131 INT10915 Gene_expression of ITGAM 164 0.78 92.42 29.78 27.60
132 INT24889 Negative_regulation of CABIN1 36 0.48 16.76 4.73 26.64
133 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 25.00
134 INT52800 Negative_regulation of Gene_expression of Tnf 142 0.59 92.27 55.47 25.00
135 INT39416 Gene_expression of Cd79a 81 0.64 45.17 6.08 22.00
136 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 20.40
137 INT36286 Binding of Cd3e 33 0.36 10.11 3.21 17.40
138 INT23577 Localization of IgG-2a 8 0.73 5.32 3.1 17.20
139 INT14849 Binding of IgG-2a 12 0.39 5.96 6.06 16.52
140 INT45753 Localization of CD40LG 45 0.79 32.31 5.28 15.44
141 INT51840 Positive_regulation of Localization of CD40LG 8 0.69 9.59 1.58 15.44
142 INT57720 Localization of IGHG3 33 0.74 20.24 6.25 14.80
143 INT192785 Regulation of Myo5a 4 0.05 9.05 0.93 14.40
144 INT135773 Negative_regulation of Gene_expression of HMOX1 31 0.53 28.31 3.32 12.28
145 INT116528 Gene_expression of HMOX1 106 0.78 86.13 12.8 11.72
146 INT47949 Positive_regulation of ELOVL1 19 0.42 29.78 3.3 11.20
147 INT16364 Gene_expression of HLA-DRA 234 0.78 118.81 45.01 5.48
148 INT82451 Negative_regulation of HMOX1 18 0.51 13.29 5.74 5.20
149 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
150 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
151 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
152 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
153 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
154 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 5.00
155 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
156 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
157 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
158 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
159 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
160 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
161 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
162 INT5056 Gene_expression of IFNG 216 0.78 137.52 74.57 5.00
163 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
164 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 5.00
165 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
166 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 5.00
167 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 5.00
168 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
169 INT9234 Negative_regulation of Gene_expression of IL6 171 0.59 101.61 53.15 5.00
170 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 5.00
171 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
172 INT2604 Positive_regulation of Got1 223 0.70 154.78 49.51 5.00
173 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 5.00
174 INT13354 Transcription of TNF 108 0.72 85.81 42.32 5.00
175 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 5.00
176 INT88322 Gene_expression of CCR5 111 0.78 77.36 39.84 5.00
177 INT163134 Gene_expression of ACR 78 0.65 30.39 38.48 5.00
178 INT12892 Negative_regulation of TIMP1 136 0.58 83.13 36.54 5.00
179 INT133028 Gene_expression of TLR2 209 0.73 131.92 36.17 5.00
180 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67 5.00
181 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19 5.00
182 INT4403 Binding of CYP2B6 113 0.48 21.17 33.83 5.00
183 INT52350 Gene_expression of CD14 184 0.75 71.37 33.13 5.00
184 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7 5.00
185 INT5117 Negative_regulation of Gene_expression of IL2 118 0.59 52.33 29.96 5.00
186 INT8097 Gene_expression of EGF 122 0.77 75.94 28.47 5.00
187 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27 5.00
188 INT22045 Gene_expression of IRF6 158 0.75 58.07 27.81 5.00
189 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6 5.00
190 INT64499 Positive_regulation of IRF6 123 0.49 52.73 27.51 5.00
191 INT16428 Positive_regulation of Gtf3a 135 0.20 106.44 26.67 5.00
192 INT73047 Positive_regulation of MMP9 133 0.68 73.22 26.42 5.00
193 INT19856 Gene_expression of CD8A 240 0.75 147.86 26.39 5.00
194 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31 5.00
195 INT15796 Regulation of IL2 66 0.61 25.43 20.62 5.00
196 INT52457 Gene_expression of ABCB1 129 0.78 38.68 19.88 5.00
197 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59 5.00
198 INT756 Gene_expression of C3 138 0.75 100.6 19.2 5.00
199 INT51054 Negative_regulation of Localization of IL6 45 0.59 24.48 18.97 5.00
200 INT117220 Positive_regulation of TLR4 64 0.69 53.61 17.33 5.00
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