D:Cannabis Dependence

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Disease Term
Synonyms ABUSE CANNABIS, ABUSE HASHISH, Abuse Marihuana, Abuse Marijuana, Cannabis Abuse, CANNABIS ADDICTION, Cannabis Related Disorder, Dependence Cannabis, Dependence Marijuana, Disorder Cannabis Related, Hashish Abuse
Documents 82
Hot Single Events 23
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Cannabis Dependence. They are ordered first by their relevance to Cannabis Dependence and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT212815 WAS Positive_regulation of CNR1 1 0.01 0.62 1.16 74.40
2 INT212824 WAS Positive_regulation of Cnr1 1 0.21 0.62 1.16 74.40
3 INT351444 Grin1 Positive_regulation of Gria2 1 0.22 1.5 2.64 68.16
4 INT292598 CNR1 Regulation of ABAT 1 0.08 0.32 0.75 50.72
5 INT292599 CNR1 Regulation of Localization of ABAT 1 0.08 0.32 0.75 50.72
6 INT210982 Binding of Cnr1 and Cfp 2 0.22 1.27 1.2 5.00
7 INT351443 Cnr1 Regulation of Positive_regulation of Vta1 1 0.12 0.93 0.99 5.00
8 INT351445 Binding of Vta1 and Positive_regulation of Casp3 1 0.01 0.39 0.64 5.00
9 INT223556 Churc1 Regulation of Cnr2 1 0.00 0.8 0.54 5.00
10 INT223558 Dpcr1 Regulation of Cms1 1 0.00 0.79 0.51 5.00
11 INT351446 Gria2 Negative_regulation of Casp3 1 0.02 0.37 0.47 5.00
12 INT218783 Binding of Faah and Cfp 1 0.04 0.55 0.45 5.00
13 INT351442 Gria2 Regulation of Gene_expression of Casp3 1 0.01 0 0.18 5.00
14 INT201378 Bdnf Regulation of Gene_expression of Ltp 1 0.00 0.21 0.07 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Cannabis Dependence. They are ordered first by their pain relevance and then by number of times they were reported in Cannabis Dependence. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT290729 Positive_regulation of Depmq1 1 0.00 0.29 0.15 100.00
2 INT74377 Regulation of Cnr1 38 0.59 16.93 24.77 99.60
3 INT113317 Regulation of Cnr2 17 0.52 10.27 10.68 99.60
4 INT73117 Positive_regulation of DNMT3B 20 0.47 10.31 5.31 98.92
5 INT212821 Positive_regulation of Sugt1 5 0.02 1.25 1.34 98.44
6 INT53385 Positive_regulation of Gene_expression of FosB 26 0.70 9.18 26.33 97.12
7 INT246706 Binding of Salc1 5 0.08 3.29 0.52 96.24
8 INT21132 Gene_expression of GABRB3 36 0.33 11.32 17.61 94.96
9 INT292608 Positive_regulation of Regulation of GABRB3 1 0.05 1.58 0.45 93.64
10 INT91913 Regulation of GRIN3B 16 0.61 11.48 14.44 93.24
11 INT261712 Regulation of GABRB3 6 0.09 3.03 3.14 93.24
12 INT121531 Negative_regulation of DNMT3B 13 0.36 3.46 3.05 90.08
13 INT212818 Binding of Chrm5 5 0.35 1.34 1.15 90.00
14 INT246705 Positive_regulation of Gene_expression of Salc1 2 0.09 2.68 0.25 88.00
15 INT246700 Gene_expression of Salc1 5 0.12 3.29 0.27 87.24
16 INT65731 Gene_expression of Cnr1 234 0.78 63.82 109.34 86.76
17 INT133038 Binding of DNMT3B 26 0.40 5.97 2.83 85.76
18 INT21527 Gene_expression of FosB 47 0.78 11.2 34.39 85.20
19 INT65730 Gene_expression of Cnr2 129 0.78 60.15 63.1 84.72
20 INT75562 Regulation of FosB 8 0.52 2.38 4.07 83.36
21 INT99077 Transcription of FosB 2 0.50 1.04 1.67 83.36
22 INT101959 Regulation of Rorb 10 0.14 5.18 3.17 82.96
23 INT211905 Negative_regulation of RIOK3 2 0.07 2.25 0.48 81.00
24 INT290728 Gene_expression of Depmq1 1 0.01 0.79 0.92 79.52
25 INT292609 Negative_regulation of Positive_regulation of DNMT3B 1 0.22 1.3 0.07 78.72
26 INT264628 Regulation of GABBR1 3 0.26 1.39 0.62 78.48
27 INT87699 Positive_regulation of WAS 16 0.45 5.84 8.03 77.32
28 INT88587 Positive_regulation of Chrna6 10 0.46 3 7.35 77.32
29 INT131767 Positive_regulation of CHRNA7 4 0.31 0.87 1.47 77.32
30 INT3854 Binding of SCD 16 0.41 11.14 3.7 75.00
31 INT6323 Positive_regulation of Gabrg1 213 0.70 45.08 124.34 74.64
32 INT62630 Positive_regulation of CNR1 86 0.70 40.34 51.51 73.56
33 INT65733 Positive_regulation of Cnr1 125 0.70 40.27 67.33 73.56
34 INT6056 Negative_regulation of Gene_expression of Fos 601 0.59 193.05 386.84 72.12
35 INT265696 Negative_regulation of Transcription of Oxt 2 0.39 0.57 1.11 72.12
36 INT167600 Gene_expression of Chrm5 15 0.72 2.4 5.48 71.12
37 INT59674 Gene_expression of Chrna6 8 0.47 2.12 3.94 70.76
38 INT5202 Positive_regulation of Gene_expression of Fos 1163 0.70 319.28 684 70.44
39 INT2838 Positive_regulation of Gene_expression of Oxt 27 0.67 6.25 6.83 70.44
40 INT101537 Gene_expression of Vta1 19 0.50 1.88 20.76 70.24
41 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 70.04
42 INT927 Gene_expression of Oxt 184 0.78 44.71 35.79 70.04
43 INT6894 Gene_expression of CNR1 168 0.78 74.07 62.84 68.52
44 INT151758 Gene_expression of PYCARD 91 0.63 14.54 24.27 68.32
45 INT267652 Negative_regulation of Gene_expression of PYCARD 6 0.37 2.35 1.22 68.32
46 INT343446 Regulation of Salc1 1 0.08 0.6 0.12 67.60
47 INT48456 Localization of WAS 6 0.56 1.63 3.95 67.44
48 INT186144 Positive_regulation of Transcription of Oxt 3 0.29 2.07 1.65 67.40
49 INT74632 Transcription of Oxt 11 0.64 3.93 3.56 67.00
50 INT215149 Binding of Sbds 5 0.22 0.44 0.48 66.88
51 INT937 Positive_regulation of Oxt 195 0.70 37.82 49.3 65.92
52 INT125980 Binding of CFD 8 0.42 10.96 1.39 65.28
53 INT111100 Gene_expression of Dusp1 18 0.76 14.81 5.21 65.00
54 INT212822 Negative_regulation of Chrm5 5 0.42 0.86 2.96 63.72
55 INT87698 Gene_expression of WAS 25 0.58 8.75 11.83 63.68
56 INT7341 Positive_regulation of Grin1 169 0.70 65.86 118.38 61.28
57 INT31774 Positive_regulation of Vta1 67 0.44 14.52 71.79 61.28
58 INT48832 Positive_regulation of Grip2 48 0.69 12.13 25.99 61.28
59 INT212820 Transcription of Chrm5 1 0.68 0.36 0.91 60.60
60 INT212819 Regulation of Chrm5 2 0.44 1.64 2.22 58.08
61 INT212817 Regulation of Regulation of Chrm5 1 0.44 0.13 0.81 58.08
62 INT6417 Negative_regulation of ABAT 49 0.51 19.6 36.81 57.76
63 INT21131 Negative_regulation of Gene_expression of ABAT 6 0.42 4.93 2.83 57.76
64 INT19488 Localization of ABAT 56 0.69 21.51 50.56 57.04
65 INT155989 Negative_regulation of Localization of ABAT 7 0.38 1.29 6.95 57.04
66 INT11246 Binding of Grin1 65 0.48 14.53 36.93 53.92
67 INT18981 Gene_expression of ABAT 78 0.68 38.35 61.36 53.76
68 INT215152 Regulation of Sbds 2 0.16 0.11 0.27 52.96
69 INT1577 Negative_regulation of Gene_expression of PRL 24 0.59 7.7 3.15 52.84
70 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 52.40
71 INT155988 Regulation of Localization of ABAT 5 0.24 2.19 6.59 50.44
72 INT7114 Positive_regulation of Ltp 1192 0.62 290.76 755.77 49.56
73 INT70816 Negative_regulation of Fos 32 0.58 13 11.18 48.80
74 INT49210 Transcription of GAD1 8 0.60 3.48 2.06 48.64
75 INT292607 Negative_regulation of Transcription of GAD1 1 0.02 0.72 0.36 48.64
76 INT292610 Negative_regulation of Transcription of ABAT 1 0.09 0.72 0.36 48.64
77 INT292605 Transcription of ABAT 1 0.15 0.71 0.32 48.64
78 INT193383 Gene_expression of SLC43A3 7 0.35 0.9 0.73 45.44
79 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 39.36
80 INT292606 Phosphorylation of PTPRK 1 0.04 0.12 0.8 35.52
81 INT212816 Positive_regulation of Chrm5 1 0.46 0.19 0.6 34.40
82 INT155878 Regulation of Gene_expression of Cnr2 4 0.62 7.57 7.25 32.96
83 INT7628 Gene_expression of Ltp 273 0.77 70.21 147.87 32.84
84 INT8152 Gene_expression of Vta1 40 0.58 19.9 46.28 32.68
85 INT124020 Negative_regulation of Gene_expression of WAS 2 0.06 0.25 0.05 31.92
86 INT117244 Gene_expression of GABBR1 5 0.33 2.19 4.36 31.76
87 INT6354 Localization of Gabrg1 321 0.74 41.41 186.74 24.24
88 INT16850 Negative_regulation of Localization of Gabrg1 73 0.51 8.28 47.89 24.24
89 INT29708 Gene_expression of Gria1 177 0.78 56.36 77.37 11.16
90 INT74745 Gene_expression of Grm8 30 0.68 9.85 14.52 11.16
91 INT114510 Positive_regulation of Gria2 36 0.57 14.91 14.85 7.12
92 INT796 Gene_expression of Penk 1902 0.78 275.47 1057.59 5.00
93 INT158 Localization of Prl 2431 0.81 378.96 952.2 5.00
94 INT728 Positive_regulation of Penk 1068 0.70 186.9 636.87 5.00
95 INT443 Localization of POMC 1020 0.81 284.52 443.17 5.00
96 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42 5.00
97 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 5.00
98 INT162 Regulation of Prl 794 0.62 165.01 322.24 5.00
99 INT4941 Positive_regulation of Oprd1 345 0.70 74.26 304.41 5.00
100 INT5379 Gene_expression of Fos 656 0.78 255.5 292.54 5.00
101 INT2909 Positive_regulation of Abat 334 0.70 62.1 256.43 5.00
102 INT9987 Gene_expression of Abat 296 0.78 95.46 226.34 5.00
103 INT767 Localization of Gnrhr 565 0.80 106.68 214.57 5.00
104 INT22548 Positive_regulation of Casp3 483 0.70 258.78 213.07 5.00
105 INT798 Positive_regulation of Gene_expression of Penk 394 0.70 78.53 203.07 5.00
106 INT156 Negative_regulation of Prl 542 0.59 131.97 192.24 5.00
107 INT4937 Negative_regulation of Oprd1 224 0.59 44.51 171.11 5.00
108 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
109 INT49134 Gene_expression of Grin1 270 0.78 84.78 148.61 5.00
110 INT14151 Gene_expression of Casp3 311 0.78 140.26 120.68 5.00
111 INT92669 Gene_expression of Bdnf 309 0.78 178.26 116.68 5.00
112 INT7944 Positive_regulation of Fos 193 0.70 60.69 98.31 5.00
113 INT69764 Positive_regulation of Cnr1 126 0.70 67.8 91.49 5.00
114 INT1639 Negative_regulation of OPRM1 107 0.59 13.86 90.37 5.00
115 INT74376 Gene_expression of Cnr1 173 0.78 73.43 89.7 5.00
116 INT10534 Positive_regulation of Trib3 209 0.60 78.75 81.48 5.00
117 INT13036 Positive_regulation of Positive_regulation of Ltp 105 0.51 23.71 77.66 5.00
118 INT6490 Negative_regulation of ADCY1 145 0.58 26.25 70.96 5.00
119 INT5573 Negative_regulation of Gene_expression of Penk 113 0.59 21.83 64.66 5.00
120 INT82055 Positive_regulation of Creb1 176 0.70 60.2 58.39 5.00
121 INT13277 Regulation of Positive_regulation of Ltp 83 0.52 19.68 55.78 5.00
122 INT19 Regulation of Gnrhr 131 0.62 36.4 55.66 5.00
123 INT4957 Negative_regulation of Grin1 87 0.59 24.51 53.21 5.00
124 INT66040 Positive_regulation of Bdnf 114 0.69 67.67 51.81 5.00
125 INT50334 Negative_regulation of Cnr1 84 0.58 30.86 51.75 5.00
126 INT57021 Positive_regulation of Gene_expression of Grin1 62 0.70 24.77 47.31 5.00
127 INT49552 Negative_regulation of Positive_regulation of Casp3 76 0.55 36.04 44.78 5.00
128 INT1564 Localization of OPRM1 41 0.80 8.03 44.67 5.00
129 INT63383 Binding of Cnr1 77 0.48 22.28 44.61 5.00
130 INT6357 Positive_regulation of Localization of Gabrg1 53 0.41 7.03 39.21 5.00
131 INT82054 Positive_regulation of Grin2b 56 0.70 17.45 37.14 5.00
132 INT95646 Negative_regulation of Faah 63 0.59 25.61 36.78 5.00
133 INT13501 Binding of Drd2 65 0.48 23.76 35.6 5.00
134 INT66005 Regulation of Cnr1 47 0.61 19.21 34.52 5.00
135 INT106554 Positive_regulation of Gene_expression of Bdnf 73 0.70 42.58 30.77 5.00
136 INT56525 Gene_expression of Gria2 74 0.75 23.15 28.6 5.00
137 INT93033 Negative_regulation of Grin2b 48 0.58 20.94 28.54 5.00
138 INT111359 Localization of Cnr1 55 0.81 11.25 27.41 5.00
139 INT75418 Negative_regulation of Cnr1 41 0.59 14.65 27.28 5.00
140 INT80470 Negative_regulation of Gene_expression of Grin1 33 0.59 10.22 27.15 5.00
141 INT56053 Negative_regulation of Bdnf 77 0.58 64.4 26.83 5.00
142 INT86789 Gene_expression of P2rx4 46 0.77 30.66 25.68 5.00
143 INT6441 Positive_regulation of CRH 98 0.69 57.22 24.12 5.00
144 INT29704 Regulation of Casp3 51 0.56 22.13 22.79 5.00
145 INT16851 Regulation of Localization of Gabrg1 34 0.39 4.34 22.29 5.00
146 INT153613 Gene_expression of Napepld 42 0.77 6.7 20.94 5.00
147 INT102203 Transcription of Bdnf 35 0.71 18.26 20.59 5.00
148 INT7581 Binding of ADHD1 132 0.46 135.1 19.73 5.00
149 INT101578 Regulation of Cnr2 26 0.62 16.7 19.12 5.00
150 INT120446 Positive_regulation of Cnr2 32 0.70 16.3 18.91 5.00
151 INT11524 Negative_regulation of Gabrd 39 0.58 6.25 18.8 5.00
152 INT66004 Binding of Cnr2 35 0.48 12.82 18.63 5.00
153 INT5198 Negative_regulation of Vta1 21 0.59 4.78 18.07 5.00
154 INT170051 Positive_regulation of Gene_expression of Gopc 150 0.43 56.75 16.93 5.00
155 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 5.00
156 INT114395 Positive_regulation of Nlrp1a 15 0.45 4.61 15.37 5.00
157 INT74375 Positive_regulation of Gene_expression of Cnr1 24 0.70 14.25 13.66 5.00
158 INT30961 Binding of HTR2A 33 0.47 11.44 12.86 5.00
159 INT107033 Gene_expression of Slc37a4 66 0.62 27.34 12.35 5.00
160 INT27507 Positive_regulation of Dio1 23 0.44 3.43 12.11 5.00
161 INT184853 Gene_expression of ADHD1 87 0.65 89.2 11.8 5.00
162 INT53201 Negative_regulation of gr 35 0.50 17.76 10.62 5.00
163 INT13499 Gene_expression of Agtr2 68 0.76 35.64 10.59 5.00
164 INT1934 Positive_regulation of Cys1 68 0.68 60.56 10.47 5.00
165 INT93036 Negative_regulation of Grin2a 23 0.50 7.1 10.32 5.00
166 INT106565 Negative_regulation of Gene_expression of Cnr1 19 0.59 6.98 9.93 5.00
167 INT8527 Positive_regulation of Positive_regulation of Fos 20 0.70 6.87 9.62 5.00
168 INT152668 Negative_regulation of EP300 13 0.38 7.78 9.03 5.00
169 INT168396 Transcription of Cnr2 12 0.72 7.69 8.74 5.00
170 INT34268 Binding of WAS 14 0.47 4.41 8.67 5.00
171 INT75907 Binding of LEP 53 0.46 46.65 8.44 5.00
172 INT78766 Negative_regulation of Gria2 20 0.52 6.27 8.12 5.00
173 INT61866 Positive_regulation of Gene_expression of Vta1 6 0.36 5.02 7.88 5.00
174 INT1150 Gene_expression of ecs 42 0.59 29.38 7.73 5.00
175 INT105505 Binding of Vta1 10 0.34 0.59 7.38 5.00
176 INT114394 Negative_regulation of Positive_regulation of Nlrp1a 4 0.42 1.09 7.37 5.00
177 INT86898 Negative_regulation of Gene_expression of Cnr1 13 0.55 3.33 7.25 5.00
178 INT102207 Positive_regulation of Transcription of Bdnf 13 0.69 5.49 7.18 5.00
179 INT36726 Regulation of Gene_expression of Ltp 14 0.46 4.81 7.05 5.00
180 INT168399 Localization of Cnr2 12 0.81 4.37 6.77 5.00
181 INT134585 Negative_regulation of Cnr2 10 0.43 3.98 6.16 5.00
182 INT157932 Positive_regulation of ADHD1 46 0.48 52.18 6.13 5.00
183 INT34370 Positive_regulation of Cfp 26 0.46 15.21 6.12 5.00
184 INT99438 Positive_regulation of Atf6b 12 0.49 4.28 5.97 5.00
185 INT67693 Binding of Grin2a 9 0.38 1.74 5.68 5.00
186 INT85946 Localization of Gria2 10 0.61 1.23 5.09 5.00
187 INT57368 Regulation of ADHD1 39 0.50 42.23 5.01 5.00
188 INT133919 Positive_regulation of Gene_expression of Cnr2 6 0.70 4.53 4.88 5.00
189 INT114511 Positive_regulation of Gene_expression of Gria2 14 0.41 3.9 4.71 5.00
190 INT189842 Negative_regulation of Gene_expression of Cnr2 8 0.59 4.21 4.67 5.00
191 INT1753 Gene_expression of Ache 38 0.78 15.31 4.58 5.00
192 INT133231 Regulation of PYCARD 18 0.39 5.02 4.44 5.00
193 INT34624 Negative_regulation of REM1 22 0.38 9.25 4.22 5.00
194 INT90983 Regulation of Gene_expression of Cnr1 8 0.45 2.59 4.03 5.00
195 INT41878 Positive_regulation of EP300 13 0.61 5.24 3.95 5.00
196 INT210975 Regulation of Cfp 10 0.24 5.3 3.93 5.00
197 INT183560 Binding of GABRB3 12 0.23 2.59 3.77 5.00
198 INT25029 Positive_regulation of Positive_regulation of CRH 7 0.49 6.77 3.52 5.00
199 INT102573 Protein_catabolism of Faah 8 0.80 2.89 3.52 5.00
200 INT191113 Positive_regulation of Transcription of Cnr2 3 0.50 3.76 3.47 5.00
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