D:Capillary Leak Syndrome

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Disease Term
Synonyms Capillary Leak Syndromes, Clinical Capillary Leak Syndrome, Systemic Capillary Leak Syndrome
Documents 30
Hot Single Events 15
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Capillary Leak Syndrome. They are ordered first by their relevance to Capillary Leak Syndrome and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT131304 Binding of Serping1 and Sele 1 0.01 1.07 0.15 49.68
2 INT351007 Binding of IL2 and IL2RA 1 0.33 1.33 0.26 23.52
3 INT180718 Binding of SARS and ACE2 3 0.12 7.76 0.25 5.00
4 INT180715 Binding of SARS and CLEC4M 2 0.12 2.92 0.11 5.00
5 INT277692 Binding of Atp9a and Tnfrsf10b 1 0.00 1.47 0.1 5.00
6 INT250804 Binding of CCL4L1 and AP5M1 1 0.01 1.48 0.08 5.00
7 INT351011 Binding of HDAC9 and TSPYL2 1 0.04 0.63 0.08 5.00
8 INT250801 Binding of AP5M1 and MAPKAP1 1 0.00 1.48 0.08 5.00
9 INT351010 ISG20 Positive_regulation of Transcription of IL2 1 0.31 0.46 0.05 5.00
10 INT351009 IL2RG Positive_regulation of Transcription of IL2 1 0.27 0.44 0.05 5.00
11 INT351012 IL2RB Positive_regulation of Gene_expression of IL15 1 0.10 0.42 0.05 5.00
12 INT351008 IL2RB Positive_regulation of Gene_expression of IL2 1 0.18 0.42 0.05 5.00
13 INT250802 Binding of IL6 and AP5M1 1 0.01 1.47 0.05 5.00
14 INT178503 Binding of Cd36 and ecs 1 0.01 0.34 0.04 5.00
15 INT283226 Binding of ACE and CC2D1A 1 0.11 2.37 0.04 5.00
16 INT250803 Binding of SARS and MBL3P 1 0.09 1.7 0.04 5.00
17 INT178501 Angpt1 Positive_regulation of Tek 1 0.06 0.78 0.04 5.00
18 INT178502 Col18a1 Negative_regulation of ecs 1 0.01 0.52 0.03 5.00
19 INT277693 Stat6 Positive_regulation of Positive_regulation of Casp3 1 0.01 1.01 0 5.00
20 INT277691 Cdkn1a Negative_regulation of Positive_regulation of Casp3 1 0.00 1.01 0 5.00
21 INT312956 Regulation of Binding of MOCS1 and MTTP 1 0.00 0.21 0 5.00
22 INT351013 PROK1 Regulation of ISG20 1 0.01 0.76 0 5.00
23 INT191540 Binding of ABCA3 and GOPC 1 0.03 0.12 0 5.00
24 INT312955 Binding of MOCS1 and MTTP 1 0.00 0.21 0 5.00
25 INT277694 Cdkn1a Positive_regulation of Positive_regulation of Casp3 1 0.00 1.01 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Capillary Leak Syndrome. They are ordered first by their pain relevance and then by number of times they were reported in Capillary Leak Syndrome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 97.08
2 INT51646 Binding of IL3 3 0.37 3.26 0.56 94.56
3 INT61087 Positive_regulation of Gene_expression of Il2ra 12 0.35 9.1 3.25 93.52
4 INT10187 Gene_expression of Il2ra 91 0.78 52.67 16.66 93.16
5 INT6852 Localization of TNF 883 0.81 705.95 270.84 90.40
6 INT4585 Gene_expression of Serping1 19 0.46 12.4 2.35 89.32
7 INT60691 Gene_expression of Il12a 331 0.78 208.03 75.96 88.92
8 INT60690 Positive_regulation of Gene_expression of Il12a 69 0.63 41.41 20.85 88.92
9 INT7205 Positive_regulation of HBG1 65 0.69 40.35 6.37 87.60
10 INT15797 Positive_regulation of HLA-E 36 0.67 15.17 5.07 87.44
11 INT234409 Gene_expression of TSPYL2 2 0.21 5.16 0.03 86.20
12 INT250818 Positive_regulation of Localization of IFNA2 4 0.12 5.06 0.2 86.00
13 INT40189 Localization of IFNA2 6 0.74 7.7 1.04 86.00
14 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 84.32
15 INT74423 Localization of IL10 91 0.80 61.6 22.95 82.56
16 INT62496 Binding of CSF1 6 0.36 4.55 1.14 79.92
17 INT174160 Binding of Il12a 19 0.24 12.61 3.4 79.08
18 INT130290 Positive_regulation of Localization of IL10 16 0.47 9.38 4.75 77.84
19 INT188630 Gene_expression of GPR84 1 0.02 14.01 9.15 75.20
20 INT88051 Regulation of Gene_expression of IL2RG 2 0.24 1.57 0.65 73.32
21 INT52968 Regulation of Gene_expression of IL2RB 2 0.16 1.57 0 73.32
22 INT23257 Regulation of CRP 127 0.62 100.05 21.87 72.96
23 INT27628 Gene_expression of IL2RG 28 0.75 20.95 6.16 72.48
24 INT11049 Gene_expression of IL2RB 8 0.60 3.73 0.76 72.48
25 INT171772 Binding of CPB1 13 0.32 9.92 0.75 69.28
26 INT70048 Positive_regulation of Gene_expression of IL10 90 0.55 71.34 25.66 68.40
27 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 68.40
28 INT312973 Binding of ACADVL 1 0.23 2.35 0.17 68.32
29 INT73502 Positive_regulation of IL10 154 0.69 124.87 43.5 68.00
30 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 66.56
31 INT262293 Gene_expression of CC2D1A 21 0.40 44.64 1.5 65.76
32 INT4137 Positive_regulation of C3 73 0.69 48.57 12.63 64.40
33 INT107942 Positive_regulation of C5 9 0.50 6.86 1.19 64.40
34 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 62.40
35 INT174491 Positive_regulation of Regulation of CRP 2 0.22 0.9 0.04 61.48
36 INT51896 Localization of PECAM1 11 0.47 9.8 1.78 60.88
37 INT63349 Gene_expression of PECAM1 199 0.75 166.03 36.76 59.76
38 INT70050 Negative_regulation of IL10 56 0.58 37.45 12.39 59.56
39 INT4587 Negative_regulation of Serping1 32 0.47 19.11 5.92 59.52
40 INT193609 Protein_catabolism of HBEGF 4 0.30 2.77 0.3 58.24
41 INT312976 Protein_catabolism of ACAT1 1 0.02 0.46 0 54.80
42 INT104549 Localization of Il18 16 0.78 13.01 4.64 52.80
43 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 51.84
44 INT9234 Negative_regulation of Gene_expression of IL6 171 0.59 101.61 53.15 51.84
45 INT107653 Gene_expression of ACAT1 9 0.60 4.74 1.03 50.40
46 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 50.00
47 INT10870 Regulation of IgG 67 0.59 43.27 12.74 50.00
48 INT22383 Binding of IL2 59 0.48 39.06 8.56 46.40
49 INT112784 Positive_regulation of Positive_regulation of IFNG 11 0.49 7.84 2.18 42.76
50 INT9210 Regulation of IL6 166 0.62 125.61 49.95 42.40
51 INT5055 Positive_regulation of IFNG 89 0.69 64.03 23.05 42.08
52 INT73497 Regulation of IL10 33 0.45 22.6 9.19 42.00
53 INT171773 Regulation of SELE 7 0.23 10.3 0.4 42.00
54 INT90881 Regulation of UBASH3B 2 0.26 0.9 0.21 42.00
55 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 41.12
56 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 40.00
57 INT3491 Negative_regulation of CPT2 8 0.57 4.32 0.62 39.40
58 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7 38.76
59 INT188628 Negative_regulation of Gene_expression of GPR84 1 0.01 3.51 2.21 37.96
60 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73 37.92
61 INT16359 Positive_regulation of Gene_expression of AGT 30 0.49 28.27 6.14 37.92
62 INT131301 Binding of Serping1 3 0.28 1.86 0.3 36.72
63 INT351017 Binding of IL2RG 1 0.17 0.44 0.16 36.40
64 INT289974 Binding of IL2RB 3 0.11 1.59 0.4 34.96
65 INT83896 Gene_expression of CD1A 19 0.68 15.58 2.1 33.80
66 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 33.44
67 INT97453 Negative_regulation of MOCS1 25 0.04 13.4 2.4 33.12
68 INT171562 Regulation of IL4 19 0.36 12.12 5.33 32.96
69 INT61417 Gene_expression of ITGAL 36 0.75 29.62 6.15 32.88
70 INT70673 Regulation of IL11 5 0.45 2.89 1.2 32.56
71 INT12157 Positive_regulation of SELL 16 0.67 14.54 5.74 31.36
72 INT133729 Positive_regulation of Gene_expression of ITGAL 8 0.49 2.96 0.48 30.44
73 INT253069 Binding of PROK1 4 0.36 0.89 0.34 26.96
74 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 26.36
75 INT148892 Binding of HPS1 13 0.37 19.21 3.35 25.60
76 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 25.00
77 INT54763 Binding of Il6 82 0.48 63.27 12.89 25.00
78 INT62497 Binding of Il4 7 0.26 4.19 3.88 25.00
79 INT48141 Binding of Csf3 18 0.39 9.93 1.71 25.00
80 INT10139 Positive_regulation of F13A1 64 0.56 44.75 9.69 22.32
81 INT8684 Positive_regulation of ANGPTL5 45 0.69 36.29 7.47 22.32
82 INT119827 Gene_expression of PTPN11 31 0.75 24.21 1.22 19.28
83 INT130194 Positive_regulation of PROK1 9 0.65 0.97 0.7 11.36
84 INT6481 Binding of TNF 624 0.48 510.2 214.82 10.60
85 INT178500 Negative_regulation of Aggf1 2 0.04 1.21 0 7.20
86 INT178488 Localization of Aggf1 9 0.08 6.18 0.5 6.48
87 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
88 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
89 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 5.00
90 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
91 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03 5.00
92 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
93 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 5.00
94 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
95 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
96 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
97 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
98 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 5.00
99 INT1760 Gene_expression of PTGER2 524 0.57 226.94 96.4 5.00
100 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 5.00
101 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
102 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.00
103 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
104 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
105 INT7534 Gene_expression of Ifng 193 0.78 111.02 68.6 5.00
106 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 5.00
107 INT11807 Gene_expression of Il2 266 0.78 112 64.97 5.00
108 INT67981 Positive_regulation of CCL2 165 0.70 136.84 61.85 5.00
109 INT39153 Positive_regulation of PTGS2 182 0.70 96.16 60.6 5.00
110 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53 5.00
111 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
112 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 5.00
113 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53 5.00
114 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 5.00
115 INT72651 Gene_expression of TH1L 114 0.75 80.15 35.15 5.00
116 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67 5.00
117 INT10763 Localization of IL2 157 0.80 81.11 33.21 5.00
118 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 5.00
119 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 5.00
120 INT9993 Positive_regulation of Gene_expression of IL2 131 0.69 46.27 30.04 5.00
121 INT90792 Localization of Il10 144 0.80 87.88 30.03 5.00
122 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 5.00
123 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
124 INT59449 Negative_regulation of Timp1 76 0.42 54.86 26.99 5.00
125 INT1761 Positive_regulation of PTGER2 135 0.49 90.17 26.26 5.00
126 INT23937 Gene_expression of EDNRA 103 0.65 55.63 24.67 5.00
127 INT86295 Gene_expression of Mmp2 114 0.76 73.68 24.25 5.00
128 INT10835 Regulation of IL8 79 0.49 53.04 24.14 5.00
129 INT79061 Positive_regulation of NOS2 92 0.65 58.89 23.96 5.00
130 INT49196 Gene_expression of SELE 105 0.78 107.29 22.92 5.00
131 INT15796 Regulation of IL2 66 0.61 25.43 20.62 5.00
132 INT20379 Localization of Il4 85 0.73 51.22 20.55 5.00
133 INT62042 Positive_regulation of Gene_expression of IL4 67 0.56 42.05 20.39 5.00
134 INT88949 Positive_regulation of Il12a 79 0.60 47.68 19.98 5.00
135 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 5.00
136 INT19509 Localization of Ifng 55 0.78 28.25 18.67 5.00
137 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 5.00
138 INT35086 Positive_regulation of Gene_expression of Ifng 40 0.69 22.55 18.35 5.00
139 INT20631 Positive_regulation of CHKB 166 0.69 109.86 17.92 5.00
140 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9 5.00
141 INT32515 Negative_regulation of B4GALNT1 82 0.43 28.1 17.46 5.00
142 INT21532 Negative_regulation of Gene_expression of Il2 47 0.59 20.43 16.96 5.00
143 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79 5.00
144 INT22900 Positive_regulation of Cd4 126 0.67 82.77 16.43 5.00
145 INT103757 Negative_regulation of Il12a 37 0.55 21.62 16.38 5.00
146 INT20622 Gene_expression of LDHA 107 0.76 77.97 16.3 5.00
147 INT3400 Positive_regulation of pr 57 0.68 36.9 16.24 5.00
148 INT59929 Negative_regulation of CYP2C9 60 0.59 16.33 15.39 5.00
149 INT81627 Gene_expression of Fas 120 0.78 115.51 15.36 5.00
150 INT20665 Gene_expression of ACE 87 0.78 51.71 14.19 5.00
151 INT172171 Gene_expression of IL15 47 0.37 46.23 13.41 5.00
152 INT7532 Negative_regulation of Gene_expression of Ifng 33 0.59 18.56 13.14 5.00
153 INT1148 Positive_regulation of ecs 38 0.48 25.27 13.1 5.00
154 INT20381 Localization of Il2 71 0.77 34.23 13.03 5.00
155 INT105670 Gene_expression of AAVS1 131 0.75 49.24 12.95 5.00
156 INT51014 Transcription of IL2 42 0.71 21.56 12.7 5.00
157 INT69158 Localization of IL4 48 0.71 31.3 11.98 5.00
158 INT15350 Localization of Prl 22 0.81 6.86 10.74 5.00
159 INT15804 Gene_expression of ISG20 83 0.75 44.33 10.58 5.00
160 INT5788 Gene_expression of IL2RA 60 0.75 40.67 9.98 5.00
161 INT49660 Positive_regulation of EGR1 54 0.69 32.17 9.89 5.00
162 INT81929 Negative_regulation of Gene_expression of IL10 41 0.57 27.99 9.87 5.00
163 INT62269 Gene_expression of Cdkn1a 60 0.73 35.78 9.84 5.00
164 INT3988 Positive_regulation of Gene_expression of IGHE 98 0.68 91.46 9.61 5.00
165 INT114874 Gene_expression of Stat3 78 0.76 53.99 9.49 5.00
166 INT1150 Gene_expression of ecs 42 0.59 29.38 7.73 5.00
167 INT16869 Positive_regulation of Prl 24 0.70 15.7 7.63 5.00
168 INT57748 Positive_regulation of Gene_expression of TP53 85 0.69 79.55 7.49 5.00
169 INT18909 Positive_regulation of Cd8a 92 0.60 56.55 7.35 5.00
170 INT102572 Gene_expression of Ccnd1 79 0.69 56.37 7.34 5.00
171 INT83006 Gene_expression of AGTR1 59 0.75 54.46 7.27 5.00
172 INT11747 Positive_regulation of IL2RA 22 0.67 16.55 6.95 5.00
173 INT16389 Gene_expression of Plg 80 0.67 36.88 6.74 5.00
174 INT10785 Gene_expression of Prl 35 0.78 20.64 6.7 5.00
175 INT117142 Gene_expression of Thbs1 58 0.72 45.02 6.51 5.00
176 INT63170 Positive_regulation of Selp 27 0.68 24.1 6.3 5.00
177 INT74109 Positive_regulation of Sele 26 0.48 22.32 5.84 5.00
178 INT17892 Gene_expression of Myc 57 0.75 36.37 5.82 5.00
179 INT62270 Positive_regulation of Gene_expression of Cdkn1a 30 0.47 18.73 5.69 5.00
180 INT32389 Regulation of ecs 11 0.49 7.23 5.43 5.00
181 INT125066 Negative_regulation of HDAC4 56 0.49 41.55 5.42 5.00
182 INT60776 Regulation of EDNRA 20 0.51 16.62 5.36 5.00
183 INT97692 Positive_regulation of HDAC9 17 0.45 14.88 5.11 5.00
184 INT141275 Negative_regulation of Gene_expression of Hand1 18 0.34 15.83 5.05 5.00
185 INT105393 Positive_regulation of Localization of VEGFA 66 0.70 45.45 4.9 5.00
186 INT17324 Negative_regulation of Plg 26 0.38 13.5 4.05 5.00
187 INT15802 Positive_regulation of Gene_expression of ISG20 16 0.42 8.16 4.03 5.00
188 INT1149 Binding of ecs 19 0.37 13.67 3.9 5.00
189 INT105975 Gene_expression of ACACA 16 0.75 5.73 3.86 5.00
190 INT2936 Gene_expression of AGL 36 0.49 9.55 3.63 5.00
191 INT170528 Negative_regulation of Gene_expression of CD4 25 0.41 17.98 3.6 5.00
192 INT12923 Negative_regulation of Atp9a 17 0.35 7.87 3.52 5.00
193 INT89966 Negative_regulation of Fas 26 0.58 24.83 3.5 5.00
194 INT62268 Positive_regulation of Cdkn1a 33 0.67 14.12 3.26 5.00
195 INT76024 Negative_regulation of Cyp3a11 7 0.53 2.96 3.16 5.00
196 INT92814 Negative_regulation of NOS3 25 0.51 20.67 3.07 5.00
197 INT146758 Gene_expression of LCN2 45 0.78 38.29 2.97 5.00
198 INT31450 Binding of HIST1H1B 20 0.37 10.21 2.84 5.00
199 INT90875 Negative_regulation of CCND1 31 0.42 26.22 2.66 5.00
200 INT155889 Binding of Nps 22 0.42 9.79 2.6 5.00
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