D:Carcinosarcoma

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Disease Term
Synonyms CARCINOSARCOMAS
Documents 98
Hot Single Events 53
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Carcinosarcoma. They are ordered first by their relevance to Carcinosarcoma and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT97314 Binding of ETFA and KRT1 1 0.07 0.75 0.08 89.16
2 INT305038 CD99 Regulation of DES 1 0.12 1.25 0 74.32
3 INT350106 Binding of SLC4A3 and SLC4A1 1 0.13 2.78 0.09 36.68
4 INT304013 Binding of SUZ12 and JAZF1 1 0.30 1.89 0 26.80
5 INT351076 IK Positive_regulation of Gene_expression of Ucp3 1 0.00 0.8 0.58 5.00
6 INT156438 Cpox Positive_regulation of Nos2 3 0.14 1.24 0.4 5.00
7 INT172905 Binding of Bad and Bcl2 3 0.08 6.46 0.27 5.00
8 INT172901 Binding of Bad and Bcl2l1 3 0.13 6.51 0.27 5.00
9 INT172895 Binding of Cpox and Selenbp2 1 0.00 0.64 0.2 5.00
10 INT172903 Fgf2 Positive_regulation of Gene_expression of Tbxa2r 1 0.03 0.58 0.15 5.00
11 INT172907 Ptger2 Negative_regulation of Gene_expression of Gtf3a 1 0.00 1.19 0.15 5.00
12 INT172913 VEGFA Positive_regulation of Gene_expression of Tbxa2r 1 0.02 0.57 0.15 5.00
13 INT172899 Binding of Bcl2 and Bcl2l1 3 0.02 5.54 0.12 5.00
14 INT172911 Cpox Positive_regulation of Gene_expression of VEGFA 1 0.01 0.72 0.09 5.00
15 INT172912 CYP4A11 Regulation of Prkca 1 0.00 0.05 0.04 5.00
16 INT172902 Binding of Bax and Bcl2 5 0.30 3.19 0.03 5.00
17 INT172892 Negative_regulation of Lox Negative_regulation of Gene_expression of Mcl1 1 0.06 1.13 0.03 5.00
18 INT172909 Cpox Regulation of Lox 1 0.03 0.51 0.03 5.00
19 INT172914 Phosphorylation of Bad Negative_regulation of Binding of Bad and Bcl2l1 1 0.00 1.25 0.03 5.00
20 INT172897 Negative_regulation of Lox Positive_regulation of Positive_regulation of Casp3 1 0.04 1.19 0.03 5.00
21 INT172910 Lox Positive_regulation of Positive_regulation of Casp3 1 0.03 1.19 0.03 5.00
22 INT172896 Lox Negative_regulation of Gene_expression of Mcl1 1 0.05 1.13 0.03 5.00
23 INT172894 Negative_regulation of Lox Negative_regulation of Gene_expression of Bcl2 1 0.03 1.12 0.03 5.00
24 INT172900 Binding of Cpox and Lox 1 0.02 0.4 0.03 5.00
25 INT280543 Binding of GAST and STAT1 1 0.05 0.58 0 5.00
26 INT172906 Binding of Bax and Bcl2l1 2 0.16 2.03 0 5.00
27 INT304029 Binding of PTEN and TP53 1 0.35 0.62 0 5.00
28 INT304020 AR Regulation of TP53 1 0.24 1.11 0 5.00
29 INT304022 Binding of PIK3CG and TP53 1 0.10 0.72 0 5.00
30 INT304028 MDM2 Regulation of TP53 1 0.19 1.11 0 5.00
31 INT304014 Binding of MSI1 and SGCG 1 0.00 1.92 0 5.00
32 INT304012 Binding of AKT1 and PIK3CA 1 0.28 1.14 0 5.00
33 INT304018 Regulation of Binding of PIK3CG and TP53 1 0.12 0.73 0 5.00
34 INT304025 Binding of PIK3CA and TP53 1 0.30 0.67 0 5.00
35 INT304015 Binding of PIK3CA and PIK3CG 1 0.09 0.67 0 5.00
36 INT172908 Binding of Bad and Bax 1 0.01 1.34 0 5.00
37 INT280546 Binding of KIT and TP63 1 0.01 1.19 0 5.00
38 INT172893 Binding of Lta4h and Ltc4s 1 0.00 0.24 0 5.00
39 INT304019 Binding of AKT1 and TP53 1 0.27 0.72 0 5.00
40 INT304026 Binding of PIK3CG and PTEN 1 0.11 0.62 0 5.00
41 INT305350 Pten Regulation of Phosphorylation of Akt1 1 0.05 0.95 0 5.00
42 INT324908 TP53 Regulation of Gene_expression of BAX 1 0.47 1.33 0 5.00
43 INT305336 TP53 Negative_regulation of Phosphorylation of RB1 1 0.29 0.96 0 5.00
44 INT304027 Negative_regulation of PTEN Positive_regulation of Positive_regulation of AKT1 1 0.32 1.86 0 5.00
45 INT304017 Regulation of Binding of AKT1 and TP53 1 0.32 0.73 0 5.00
46 INT304023 SFRP1 Regulation of Binding of MSI1 1 0.04 1.78 0 5.00
47 INT304016 SFRP4 Regulation of Binding of MSI1 1 0.04 1.78 0 5.00
48 INT324909 Negative_regulation of TP53 Positive_regulation of Negative_regulation of BAX 1 0.36 1.33 0 5.00
49 INT304024 Binding of AKT1 and PTEN 1 0.33 1.08 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Carcinosarcoma. They are ordered first by their pain relevance and then by number of times they were reported in Carcinosarcoma. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT330572 Phosphorylation of CD68 1 0.60 1.26 0.04 99.88
2 INT5206 Gene_expression of AR 316 0.78 113.83 27.29 99.86
3 INT94454 Gene_expression of CD68 73 0.72 63.94 10.43 99.32
4 INT91209 Binding of VIM 15 0.36 12.02 0.53 99.00
5 INT97367 Gene_expression of Nav1 243 0.78 132.97 286.66 98.76
6 INT20421 Positive_regulation of MYC 19 0.67 10.43 1.9 98.68
7 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36 98.32
8 INT117675 Transcription of Nav1 46 0.72 30.23 44.01 98.20
9 INT82450 Negative_regulation of Hmox1 33 0.55 19.07 8.12 97.70
10 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 96.96
11 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 96.96
12 INT190204 Positive_regulation of Gene_expression of MMP12 22 0.67 31.31 13.69 96.96
13 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 96.76
14 INT20492 Gene_expression of MMP12 89 0.76 81.36 46.12 96.76
15 INT102429 Negative_regulation of Gene_expression of Nav1 19 0.59 20.09 28.09 96.08
16 INT65262 Gene_expression of Lox 47 0.74 36.59 5.65 95.60
17 INT154233 Negative_regulation of Lox 32 0.56 38.89 3.17 95.32
18 INT4988 Gene_expression of KRT1 64 0.77 43.4 4.12 94.88
19 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 93.68
20 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 93.68
21 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66 92.60
22 INT70242 Localization of HCC 18 0.66 23.95 2.35 91.88
23 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 91.64
24 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 91.28
25 INT183933 Binding of CD68 8 0.31 8.74 1.06 90.32
26 INT109967 Gene_expression of Mmv7 21 0.35 15.66 1.7 90.08
27 INT35391 Negative_regulation of Nefm 7 0.27 3.17 1.73 90.00
28 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81 89.60
29 INT11161 Gene_expression of HLA-DRB1 121 0.78 75.33 20.96 89.60
30 INT91527 Gene_expression of CTSK 38 0.78 22.21 7.42 89.60
31 INT81578 Gene_expression of TRAP 25 0.72 9.75 2.82 89.60
32 INT21682 Binding of CD34 18 0.47 13.19 1.47 89.60
33 INT5841 Gene_expression of Vim 181 0.72 138.54 16.33 89.12
34 INT111476 Gene_expression of TP63 88 0.76 61.08 11.64 89.12
35 INT59784 Binding of DES 22 0.47 19.48 2.27 89.12
36 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 89.08
37 INT131931 Binding of KRT7 13 0.36 19.24 0.5 88.48
38 INT82568 Protein_catabolism of Hmox1 5 0.86 1.03 0.79 86.08
39 INT28084 Positive_regulation of VIM 49 0.67 35.12 5.15 85.64
40 INT10048 Positive_regulation of SERPINA1 11 0.68 8.59 2.43 85.64
41 INT97245 Gene_expression of AKT1 217 0.77 119.63 15.59 84.64
42 INT17915 Gene_expression of Insr 141 0.75 47.45 48.59 83.60
43 INT97315 Positive_regulation of LGALS3 2 0.58 1.6 0.66 82.52
44 INT171666 Regulation of GOPC 117 0.39 40.41 15.47 82.44
45 INT111477 Gene_expression of KRT7 90 0.74 86.76 4.07 82.40
46 INT44478 Negative_regulation of PTEN 32 0.57 27.45 0.63 81.76
47 INT75137 Regulation of Akt1 74 0.48 37.89 9.7 81.64
48 INT111607 Gene_expression of CDH1 103 0.75 90.45 7.77 81.20
49 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 81.20
50 INT48219 Gene_expression of SLC4A1 34 0.75 33.18 2.84 81.12
51 INT104330 Negative_regulation of CDKN1A 57 0.58 39.93 5.88 80.96
52 INT92141 Negative_regulation of CDKN2A 53 0.57 44.23 2.48 80.96
53 INT140637 Negative_regulation of IFI27 11 0.40 9.48 0.69 80.96
54 INT304056 Gene_expression of SNAI2 1 0.65 0.66 0 79.36
55 INT304059 Gene_expression of GEMIN2 1 0.12 0.66 0 79.36
56 INT64766 Gene_expression of TWIST1 41 0.76 37.89 3.4 79.36
57 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 78.68
58 INT18672 Gene_expression of Ncam1 54 0.78 36.64 18.79 78.00
59 INT84894 Gene_expression of Calb2 45 0.73 24.65 7.81 75.80
60 INT97366 Regulation of Nav1 38 0.62 23.63 38.17 75.68
61 INT97368 Negative_regulation of Nav1 62 0.59 41.56 60.27 75.48
62 INT194993 Binding of RB1 15 0.37 10.96 0.4 75.20
63 INT14446 Binding of TRAFD1 2 0.03 0.93 0.11 75.20
64 INT2792 Gene_expression of Mb 91 0.76 41.56 10.25 75.00
65 INT27242 Gene_expression of PGR 153 0.75 98.77 12.79 74.20
66 INT111605 Positive_regulation of CDH1 12 0.50 7.95 1.15 73.84
67 INT305345 Positive_regulation of Snai2 1 0.16 1.4 0 73.84
68 INT236621 Regulation of KRAS 7 0.53 6.16 0 73.28
69 INT304076 Regulation of Localization of KRAS 2 0.36 2.39 0 73.28
70 INT180396 Localization of KRAS 3 0.69 2.89 0 73.28
71 INT172873 Gene_expression of Alox8 1 0.14 1.32 0 73.08
72 INT179885 Regulation of PTEN 8 0.26 11.88 2.18 72.80
73 INT161322 Localization of PTEN 9 0.73 5.65 0.57 72.80
74 INT304062 Regulation of Localization of PTEN 1 0.43 1.29 0 72.80
75 INT72782 Positive_regulation of HCC 41 0.40 63.74 2.46 72.68
76 INT304047 Positive_regulation of Transcription of TWIST1 1 0.10 0.57 0 72.32
77 INT304067 Positive_regulation of Transcription of GEMIN2 1 0.09 0.57 0 72.32
78 INT304046 Positive_regulation of Transcription of SNAI2 1 0.49 0.57 0 72.32
79 INT57748 Positive_regulation of Gene_expression of TP53 85 0.69 79.55 7.49 72.24
80 INT68269 Gene_expression of CD99 49 0.77 47.38 3.86 71.92
81 INT304055 Transcription of TWIST1 1 0.14 0.57 0 71.36
82 INT139237 Negative_regulation of Gene_expression of CDH1 23 0.57 24.31 1.28 70.76
83 INT304065 Transcription of GEMIN2 1 0.12 0.57 0 70.48
84 INT304049 Transcription of SNAI2 1 0.67 0.56 0 69.92
85 INT307 Regulation of Ptger1 14 0.42 4.57 2.72 69.76
86 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61 69.52
87 INT4991 Positive_regulation of Vim 74 0.69 69.84 8.33 68.36
88 INT23955 Regulation of Vim 16 0.25 14.21 2.04 68.36
89 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 62.72
90 INT330573 Gene_expression of ART1 1 0.01 0.5 0 62.16
91 INT17459 Positive_regulation of Gene_expression of FOS 182 0.67 53.45 96.38 60.88
92 INT89774 Gene_expression of NR4A1 13 0.77 9.47 1.02 59.20
93 INT280564 Negative_regulation of Gene_expression of PSMB9 5 0.54 5.99 0.41 57.48
94 INT109721 Gene_expression of Syt2 1 0.04 2.42 0.21 57.16
95 INT106616 Gene_expression of PSMB9 35 0.72 28.4 2.29 57.08
96 INT125467 Positive_regulation of Gene_expression of CDKN2A 35 0.63 39.07 5.56 55.68
97 INT154527 Gene_expression of POU5F1 180 0.78 34.01 4.34 55.44
98 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 54.40
99 INT172860 Positive_regulation of Alox8 1 0.09 1.08 0 52.72
100 INT20664 Binding of ACE 60 0.48 35.27 9.16 52.44
101 INT43084 Binding of Ace 10 0.46 4.7 1.93 52.44
102 INT117674 Regulation of Gene_expression of Nav1 16 0.62 11.5 22.01 52.32
103 INT86780 Positive_regulation of Hmox1 145 0.70 117.09 31.18 51.80
104 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 49.04
105 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 47.44
106 INT8413 Gene_expression of Ptgs1 248 0.78 110.17 108.58 46.72
107 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3 46.40
108 INT89794 Positive_regulation of CDKN2A 58 0.67 50.18 5.38 44.56
109 INT2036 Localization of EGF 42 0.77 21.5 9.74 43.76
110 INT11157 Binding of EGF 88 0.48 53.73 21.25 42.48
111 INT75501 Gene_expression of CCND1 90 0.76 60.86 5.93 41.92
112 INT110633 Binding of Nav1 15 0.42 4.34 9.38 41.52
113 INT47030 Negative_regulation of ARMC9 22 0.38 13.08 0.47 39.92
114 INT11814 Positive_regulation of Alb 43 0.63 31.71 6.28 38.32
115 INT29327 Positive_regulation of Ace 13 0.67 8.79 4.33 38.32
116 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 34.60
117 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 34.00
118 INT179300 Negative_regulation of TGFB1I1 1 0.06 1.92 0 33.88
119 INT90875 Negative_regulation of CCND1 31 0.42 26.22 2.66 33.68
120 INT11158 Positive_regulation of Gene_expression of EGFR 165 0.70 131.26 4.93 33.16
121 INT57749 Negative_regulation of Gene_expression of TP53 39 0.56 36.79 4.45 30.40
122 INT107985 Gene_expression of MLH1 29 0.67 31.31 1.46 29.28
123 INT181744 Negative_regulation of Gene_expression of MLH1 3 0.05 7.67 0.12 29.28
124 INT209451 Regulation of Gene_expression of TP63 3 0.16 4.32 0 27.72
125 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 26.80
126 INT190186 Negative_regulation of Gene_expression of MMP12 5 0.38 5.37 2.17 26.80
127 INT132760 Gene_expression of Pgr 47 0.66 28.17 2.85 24.72
128 INT65684 Gene_expression of MDM2 30 0.62 24.94 1.55 24.08
129 INT268686 Gene_expression of JAZF1 2 0.68 9.33 0 21.88
130 INT305352 Gene_expression of HOXA11 1 0.23 1.22 0 21.52
131 INT8546 Positive_regulation of MUC16 99 0.69 74.98 11.26 21.28
132 INT6511 Positive_regulation of AFP 76 0.70 70.15 7.28 21.28
133 INT250899 Gene_expression of Thbs2 17 0.75 4.97 0.13 21.20
134 INT170313 Gene_expression of Mmp1a 50 0.65 38.53 21.36 21.12
135 INT170324 Negative_regulation of Gene_expression of Mmp1a 8 0.13 6.28 2.94 21.12
136 INT172554 Positive_regulation of Gene_expression of Mmp1a 7 0.16 4.48 2.05 21.12
137 INT105336 Regulation of AKT1 52 0.56 32.53 4.89 20.40
138 INT108204 Regulation of PIK3CG 9 0.12 4.16 0.75 20.40
139 INT95328 Gene_expression of Gstp1 11 0.61 8.59 0.48 19.32
140 INT87406 Gene_expression of GSTP1 16 0.77 11.37 0.35 19.32
141 INT305348 Gene_expression of Peg3 2 0.25 2.36 0.31 19.32
142 INT304050 Gene_expression of SUZ12 1 0.54 6.53 0 19.24
143 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 18.72
144 INT9658 Negative_regulation of Gene_expression of Il6 110 0.59 66.29 32.58 18.72
145 INT120761 Positive_regulation of GSTP1 3 0.50 3.4 0.19 17.04
146 INT172858 Negative_regulation of Alox5ap 1 0.09 2.11 0.08 16.32
147 INT172678 Gene_expression of NUPL2 20 0.75 5.06 2.85 13.12
148 INT21788 Positive_regulation of ERBB2 49 0.66 28.88 1.68 12.64
149 INT57252 Negative_regulation of PGR 22 0.43 12.95 3.33 10.72
150 INT172556 Negative_regulation of Localization of Proc 3 0.01 5.81 0.19 8.96
151 INT172559 Localization of Proc 16 0.02 21.49 2.08 8.44
152 INT62331 Gene_expression of TNFRSF8 26 0.72 17.75 2.08 6.96
153 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52 6.88
154 INT6510 Gene_expression of AFP 130 0.78 119.2 9.19 6.56
155 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 6.00
156 INT109005 Gene_expression of Proc 61 0.75 37.86 8.49 5.48
157 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
158 INT49441 Negative_regulation of Cpox 494 0.59 303.22 177.46 5.00
159 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 5.00
160 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 5.00
161 INT49439 Gene_expression of Cpox 508 0.73 326.97 130.17 5.00
162 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03 5.00
163 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 5.00
164 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
165 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 5.00
166 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 5.00
167 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43 5.00
168 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
169 INT60691 Gene_expression of Il12a 331 0.78 208.03 75.96 5.00
170 INT39565 Gene_expression of Ptger2 424 0.75 229.28 72.68 5.00
171 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
172 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
173 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
174 INT9196 Gene_expression of PTGS1 215 0.77 96.99 60.5 5.00
175 INT31116 Gene_expression of Casp3 192 0.78 78.21 57.43 5.00
176 INT52264 Gene_expression of IK 180 0.77 90.87 51.87 5.00
177 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82 5.00
178 INT60695 Positive_regulation of Gene_expression of Il10 154 0.70 120.28 43.07 5.00
179 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 5.00
180 INT63349 Gene_expression of PECAM1 199 0.75 166.03 36.76 5.00
181 INT17381 Gene_expression of Tbxa2r 146 0.78 65.01 34.15 5.00
182 INT48924 Positive_regulation of Mapk3 107 0.67 50.53 34.05 5.00
183 INT67039 Positive_regulation of Cpox 144 0.65 98.4 33.77 5.00
184 INT11325 Gene_expression of HLA-E 209 0.76 98.05 33.72 5.00
185 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
186 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 5.00
187 INT72375 Phosphorylation of Mapk3 87 0.80 43.66 30.27 5.00
188 INT115909 Positive_regulation of Gene_expression of Nav1 25 0.70 16.58 27.63 5.00
189 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 5.00
190 INT20462 Binding of ESR1 210 0.44 102.7 26.34 5.00
191 INT47075 Positive_regulation of Ptger2 142 0.70 78.55 25.47 5.00
192 INT172458 Regulation of Gopc 155 0.53 62.57 24.86 5.00
193 INT86295 Gene_expression of Mmp2 114 0.76 73.68 24.25 5.00
194 INT22708 Gene_expression of MUC1 297 0.78 232.71 24.19 5.00
195 INT72370 Gene_expression of Timp1 82 0.65 57.52 24.16 5.00
196 INT9292 Positive_regulation of SGCG 93 0.67 35.13 23.48 5.00
197 INT69993 Positive_regulation of Gene_expression of Cpox 93 0.55 69.4 22.05 5.00
198 INT73593 Gene_expression of BAX 173 0.76 147.81 20.94 5.00
199 INT50814 Positive_regulation of Mmp2 72 0.68 51.37 20.42 5.00
200 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61 5.00
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