D:Cardiomegaly

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Disease Term
Synonyms CARDIAC HYPERTROPHY, Enlarged Heart, Enlargement Heart, Heart Enlarged, HEART ENLARGEMENT, HEART HYPERTROPHY
Documents 45
Hot Single Events 8
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Cardiomegaly. They are ordered first by their relevance to Cardiomegaly and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT93415 Binding of Myo5b and Avpr1b 1 0.01 0.26 0.06 89.28
2 INT188318 MCPH1 Positive_regulation of Pah 3 0.02 3 0.85 5.00
3 INT329323 ecs Positive_regulation of Gene_expression of Il6 1 0.00 0.52 0.21 5.00
4 INT217661 LEP Positive_regulation of INS 2 0.25 1.85 0.19 5.00
5 INT217665 ADIPOQ Positive_regulation of INS 2 0.06 1.8 0.19 5.00
6 INT329324 KNG1 Positive_regulation of Localization of ecs 1 0.00 1.16 0.17 5.00
7 INT329317 ACE Regulation of Positive_regulation of KNG1 1 0.02 1.05 0.12 5.00
8 INT329325 ACE Regulation of Negative_regulation of Agtr2 1 0.01 0.93 0.12 5.00
9 INT267156 Binding of VDR and SUGT1 1 0.04 3.4 0.09 5.00
10 INT267154 ADIPOQ Regulation of Positive_regulation of SUGT1 1 0.03 1.18 0.08 5.00
11 INT267152 Binding of LEP and DDX12P 1 0.00 0.69 0.05 5.00
12 INT267157 LEP Positive_regulation of ADIPOQ 1 0.10 0.51 0.05 5.00
13 INT267158 Binding of IRS1 and SHMT2 1 0.02 0.46 0.05 5.00
14 INT267153 Binding of LEP and SUGT1 1 0.02 0.69 0.05 5.00
15 INT343719 Nlrp1a Positive_regulation of PAH 1 0.00 1.9 0.04 5.00
16 INT267155 Binding of INS and SUGT1 1 0.02 0.81 0.04 5.00
17 INT312956 Regulation of Binding of MOCS1 and MTTP 1 0.00 0.21 0 5.00
18 INT312955 Binding of MOCS1 and MTTP 1 0.00 0.21 0 5.00
19 INT343716 Nos3 Positive_regulation of Pde6b 1 0.20 0 0 5.00
20 INT343718 Nos3 Regulation of Pde6b 1 0.10 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Cardiomegaly. They are ordered first by their pain relevance and then by number of times they were reported in Cardiomegaly. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT33053 Positive_regulation of Cox6c 9 0.69 3.74 2.23 99.00
2 INT33054 Negative_regulation of Positive_regulation of Cox6c 1 0.58 0.7 0.38 99.00
3 INT343711 Negative_regulation of Gene_expression of Adh5 1 0.20 0.1 0.13 95.92
4 INT250289 Gene_expression of Adh5 2 0.38 1.04 0.21 95.32
5 INT251 Regulation of INS 398 0.62 232.47 55.04 93.32
6 INT67589 Gene_expression of MT1E 8 0.51 7.52 1.09 93.08
7 INT125775 Positive_regulation of Serpinb2 7 0.36 3.81 0.9 86.76
8 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 80.56
9 INT66457 Negative_regulation of Avpr1b 2 0.20 0.65 0.08 79.36
10 INT10874 Negative_regulation of Twist1 89 0.50 36.84 11.32 73.36
11 INT114498 Positive_regulation of MCPH1 10 0.43 5.82 0.91 69.76
12 INT11858 Localization of Tbxa2r 39 0.80 21.24 7.09 69.00
13 INT5160 Localization of PTAFR 61 0.80 42.6 19.16 69.00
14 INT10053 Localization of Paf 15 0.80 9.14 3.64 69.00
15 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 67.20
16 INT20631 Positive_regulation of CHKB 166 0.69 109.86 17.92 59.48
17 INT188310 Binding of Pde4b 2 0.06 0.77 0.18 59.00
18 INT188309 Binding of Pde4dl1 1 0.22 0.2 0 59.00
19 INT1375 Negative_regulation of Pde4dl1 13 0.57 5.54 4.63 58.32
20 INT1216 Negative_regulation of Pde4b 9 0.41 2.65 2.5 57.88
21 INT68216 Binding of NF1 40 0.48 51.24 4.59 41.36
22 INT22965 Positive_regulation of Pah 42 0.61 41.41 8.84 36.16
23 INT79395 Gene_expression of Twist1 193 0.77 100.06 26.34 34.88
24 INT63932 Positive_regulation of Ephb1 537 0.70 259.67 296.14 27.64
25 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27 27.64
26 INT10534 Positive_regulation of Trib3 209 0.60 78.75 81.48 27.64
27 INT188315 Positive_regulation of Crk 1 0.49 0.09 0 27.64
28 INT15540 Positive_regulation of PDGFA 24 0.47 19.01 2.5 22.92
29 INT188317 Positive_regulation of Gene_expression of PDGFA 15 0.46 12.7 0.91 22.92
30 INT71928 Positive_regulation of Gene_expression of Smc1b 5 0.14 1.65 0.43 22.92
31 INT95117 Gene_expression of PDGFA 71 0.71 51.17 6.9 22.60
32 INT71926 Gene_expression of Smc1b 6 0.35 3.64 1.27 21.72
33 INT312967 Positive_regulation of Binding of AGL 1 0.03 0.55 0 20.68
34 INT76902 Binding of AGL 3 0.02 2.23 0.64 20.44
35 INT63935 Positive_regulation of Gene_expression of Ephb1 52 0.61 24.3 33.05 19.48
36 INT48923 Gene_expression of Ephb1 211 0.77 106.23 109.9 19.08
37 INT188308 Negative_regulation of Gene_expression of Smc1b 1 0.12 0.07 0 8.08
38 INT35745 Negative_regulation of AGL 29 0.50 9.16 2.03 6.92
39 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
40 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58 5.00
41 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 5.00
42 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
43 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 5.00
44 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
45 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
46 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
47 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43 5.00
48 INT12536 Localization of Prkcg 101 0.80 36.37 73.81 5.00
49 INT7534 Gene_expression of Ifng 193 0.78 111.02 68.6 5.00
50 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 5.00
51 INT11491 Positive_regulation of KNG1 128 0.67 60.41 58.74 5.00
52 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
53 INT65245 Gene_expression of Nos3 121 0.78 98.14 41.56 5.00
54 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 5.00
55 INT77434 Positive_regulation of Gene_expression of Nos2 151 0.69 96.76 38.94 5.00
56 INT68975 Gene_expression of Mmp9 111 0.78 79.57 38.55 5.00
57 INT63349 Gene_expression of PECAM1 199 0.75 166.03 36.76 5.00
58 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61 5.00
59 INT65055 Negative_regulation of Nfkb1 83 0.58 44.85 34.94 5.00
60 INT17381 Gene_expression of Tbxa2r 146 0.78 65.01 34.15 5.00
61 INT29503 Gene_expression of Mmp2 95 0.77 56.92 31.68 5.00
62 INT68973 Positive_regulation of Mmp9 89 0.52 58.56 30.04 5.00
63 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43 5.00
64 INT11361 Gene_expression of SERPINE1 183 0.78 136.45 27.97 5.00
65 INT15390 Positive_regulation of Edn1 64 0.70 47.36 23.8 5.00
66 INT74682 Positive_regulation of Mmp2 72 0.69 40.46 21.73 5.00
67 INT4535 Localization of PROC 106 0.73 76.24 21.1 5.00
68 INT82434 Positive_regulation of LEP 117 0.70 95.45 20.22 5.00
69 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59 5.00
70 INT27670 Negative_regulation of Ace 122 0.57 79.21 18.08 5.00
71 INT71680 Gene_expression of CCL3 43 0.75 33.7 18.01 5.00
72 INT9656 Regulation of Gene_expression of Il6 57 0.62 33.3 17.71 5.00
73 INT32515 Negative_regulation of B4GALNT1 82 0.43 28.1 17.46 5.00
74 INT3364 Binding of SGCG 87 0.47 31.93 17.24 5.00
75 INT3002 Binding of SUGT1 62 0.24 55.9 14.91 5.00
76 INT18773 Localization of ALB 117 0.80 69.18 13.8 5.00
77 INT13823 Gene_expression of Egf 97 0.78 39.99 12.99 5.00
78 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83 5.00
79 INT2673 Negative_regulation of PROC 93 0.57 50.34 12.79 5.00
80 INT121242 Positive_regulation of Gene_expression of Nos3 37 0.69 31.96 12.71 5.00
81 INT73431 Positive_regulation of Nos3 82 0.65 53.22 11.61 5.00
82 INT48009 Gene_expression of Pde6b 38 0.68 15.03 11.41 5.00
83 INT68976 Positive_regulation of Gene_expression of Mmp9 34 0.42 28.21 11.28 5.00
84 INT52233 Transcription of Jun 37 0.66 6.39 11.15 5.00
85 INT32007 Gene_expression of ECT 56 0.62 18.94 11.13 5.00
86 INT4605 Negative_regulation of Gene_expression of INS 220 0.58 139.66 10.75 5.00
87 INT74681 Positive_regulation of Gene_expression of Mmp2 23 0.55 15.58 10.74 5.00
88 INT86361 Positive_regulation of Positive_regulation of NOS1 39 0.53 18.93 10.42 5.00
89 INT100379 Positive_regulation of HIF1A 69 0.69 57.31 10.4 5.00
90 INT15449 Positive_regulation of Plat 32 0.69 12.76 9.71 5.00
91 INT11859 Positive_regulation of Tbxa2r 44 0.61 22.62 9.61 5.00
92 INT18145 Positive_regulation of Gene_expression of Tbxa2r 30 0.66 18.91 9.52 5.00
93 INT17101 Positive_regulation of Gene_expression of Edn1 24 0.69 24.9 8.86 5.00
94 INT12095 Negative_regulation of Edn1 26 0.59 12.01 8.79 5.00
95 INT19185 Negative_regulation of Cd4 80 0.51 61.32 8.51 5.00
96 INT62944 Regulation of Icam1 33 0.47 23.52 7.94 5.00
97 INT172789 Regulation of Gene_expression of Nos3 15 0.53 16.23 7.86 5.00
98 INT47994 Negative_regulation of Lipg 45 0.50 27.19 7.24 5.00
99 INT137454 Gene_expression of ADIPOQ 88 0.78 85.32 6.2 5.00
100 INT135170 Positive_regulation of Hif1a 86 0.67 99.4 6.07 5.00
101 INT29368 Binding of ECT 25 0.41 11.65 5.81 5.00
102 INT21647 Negative_regulation of Positive_regulation of KNG1 11 0.43 5.54 5.73 5.00
103 INT63351 Negative_regulation of Gene_expression of PECAM1 19 0.52 16.06 5.73 5.00
104 INT84909 Positive_regulation of SUGT1 22 0.08 22.01 5.43 5.00
105 INT32389 Regulation of ecs 11 0.49 7.23 5.43 5.00
106 INT82354 Positive_regulation of PECAM1 25 0.34 22.93 4.69 5.00
107 INT87632 Positive_regulation of Gene_expression of PECAM1 32 0.45 29.47 4.66 5.00
108 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62 5.00
109 INT84911 Gene_expression of SUGT1 43 0.11 19.85 4.54 5.00
110 INT119498 Positive_regulation of Pde6b 11 0.43 18.75 4.22 5.00
111 INT65926 Positive_regulation of Gene_expression of Egf 26 0.70 12.91 4.18 5.00
112 INT48008 Negative_regulation of Pde6b 9 0.15 6.12 4.11 5.00
113 INT1149 Binding of ecs 19 0.37 13.67 3.9 5.00
114 INT105975 Gene_expression of ACACA 16 0.75 5.73 3.86 5.00
115 INT84852 Transcription of Nfkb1 12 0.67 4.28 3.84 5.00
116 INT2936 Gene_expression of AGL 36 0.49 9.55 3.63 5.00
117 INT59900 Binding of MATN3 13 0.42 17.19 3.59 5.00
118 INT31925 Negative_regulation of Agtr2 13 0.43 7.59 2.94 5.00
119 INT32623 Negative_regulation of Regulation of INS 16 0.43 10.96 2.9 5.00
120 INT110811 Positive_regulation of Mmp1 5 0.60 2.96 2.83 5.00
121 INT97452 Positive_regulation of MOCS1 20 0.39 11.4 2.59 5.00
122 INT136335 Regulation of Mmp10 4 0.11 1.53 2.54 5.00
123 INT127458 Positive_regulation of PAH 24 0.58 27.25 2.53 5.00
124 INT76713 Regulation of Gene_expression of PECAM1 16 0.40 14.52 2.51 5.00
125 INT128773 Regulation of Gene_expression of Pde6b 4 0.45 1.41 2.5 5.00
126 INT111451 Regulation of ADIPOQ 24 0.56 18.81 2.47 5.00
127 INT97453 Negative_regulation of MOCS1 25 0.04 13.4 2.4 5.00
128 INT73809 Regulation of Nos3 18 0.45 10.05 2.27 5.00
129 INT142626 Negative_regulation of Localization of ALB 9 0.55 6.63 2.24 5.00
130 INT48007 Regulation of Pde6b 6 0.39 4.4 2.2 5.00
131 INT100381 Positive_regulation of Positive_regulation of HIF1A 12 0.49 12.05 2.17 5.00
132 INT141299 Negative_regulation of Gene_expression of Nos3 9 0.55 5.38 2.17 5.00
133 INT37394 Localization of ecs 9 0.34 6.41 2.11 5.00
134 INT76532 Binding of Nos3 13 0.37 9.32 1.87 5.00
135 INT56925 Negative_regulation of TSC1 54 0.52 63.39 1.87 5.00
136 INT48722 Negative_regulation of Gene_expression of SERPINE1 12 0.43 7.66 1.85 5.00
137 INT56028 Regulation of Ncam1 6 0.38 3.6 1.78 5.00
138 INT108798 Negative_regulation of Positive_regulation of ALPP 9 0.25 4.26 1.46 5.00
139 INT188305 Protein_catabolism of Col4a2 3 0.12 2.45 1.43 5.00
140 INT140858 Negative_regulation of SUGT1 9 0.05 8.41 1.4 5.00
141 INT33520 Negative_regulation of CYC1 11 0.57 5.36 1.26 5.00
142 INT212983 Positive_regulation of Positive_regulation of Nos3 9 0.51 7.08 1.23 5.00
143 INT61993 Gene_expression of NF1 29 0.78 34.47 1.23 5.00
144 INT136337 Positive_regulation of Mmp10 1 0.12 0.91 1.2 5.00
145 INT17802 Transcription of Edn1 6 0.24 6.31 1.18 5.00
146 INT86063 Positive_regulation of Positive_regulation of Mmp9 4 0.35 2.34 1.17 5.00
147 INT87233 Gene_expression of ECE1 12 0.65 3.54 1.12 5.00
148 INT127459 Negative_regulation of PAH 18 0.56 15.15 1.05 5.00
149 INT107653 Gene_expression of ACAT1 9 0.60 4.74 1.03 5.00
150 INT19849 Positive_regulation of Smc1b 8 0.50 4.09 1.01 5.00
151 INT60122 Negative_regulation of MADD 3 0.11 2.23 0.93 5.00
152 INT122652 Regulation of B4GALNT1 5 0.11 1.76 0.88 5.00
153 INT297531 Negative_regulation of Ece1 5 0.32 5.49 0.87 5.00
154 INT173422 Gene_expression of ETFDH 11 0.45 5.78 0.78 5.00
155 INT122572 Phosphorylation of Nos3 37 0.65 25.23 0.75 5.00
156 INT186523 Binding of ETFDH 10 0.25 5.63 0.72 5.00
157 INT19848 Regulation of Smc1b 4 0.61 2.06 0.71 5.00
158 INT268451 Positive_regulation of Gene_expression of ECE1 3 0.49 1.99 0.67 5.00
159 INT110806 Positive_regulation of Mmp8 7 0.46 1.64 0.67 5.00
160 INT202715 Binding of NMS 3 0.27 6.92 0.65 5.00
161 INT3491 Negative_regulation of CPT2 8 0.57 4.32 0.62 5.00
162 INT5261 Localization of AGL 10 0.36 3.17 0.61 5.00
163 INT98609 Negative_regulation of PYGM 11 0.43 6.21 0.6 5.00
164 INT202716 Gene_expression of NMS 4 0.49 4.56 0.57 5.00
165 INT74630 Negative_regulation of ACADVL 8 0.58 2.49 0.53 5.00
166 INT69947 Negative_regulation of MTAP 5 0.40 2.63 0.48 5.00
167 INT329319 Positive_regulation of Transcription of Ece1 1 0.08 2.64 0.48 5.00
168 INT153067 Positive_regulation of Positive_regulation of Hif1a 10 0.49 11.83 0.47 5.00
169 INT152425 Positive_regulation of Positive_regulation of Pde6b 2 0.18 1.74 0.46 5.00
170 INT175423 Positive_regulation of TSC1 25 0.36 21.81 0.45 5.00
171 INT160514 Regulation of Positive_regulation of Pah 1 0.22 1.62 0.45 5.00
172 INT119499 Regulation of Positive_regulation of Pde6b 2 0.11 0.8 0.43 5.00
173 INT144095 Localization of Nos3 8 0.57 4.5 0.43 5.00
174 INT93926 Gene_expression of Ece1 3 0.27 2.31 0.42 5.00
175 INT324886 Transcription of Ece1 2 0.37 1.95 0.4 5.00
176 INT121475 Regulation of Negative_regulation of Twist1 3 0.14 2.43 0.24 5.00
177 INT329320 Positive_regulation of Gene_expression of Ece1 1 0.09 1.31 0.24 5.00
178 INT124714 Localization of PFKM 2 0.37 1.45 0.21 5.00
179 INT249115 Localization of Pde6b 6 0.68 1.09 0.21 5.00
180 INT177938 Negative_regulation of NF1 9 0.43 10.3 0.2 5.00
181 INT112171 Regulation of MB 2 0.22 0.23 0.19 5.00
182 INT267166 Binding of DDX12P 1 0.01 3.34 0.18 5.00
183 INT343714 Negative_regulation of Positive_regulation of Pde6b 1 0.15 1.87 0.17 5.00
184 INT312973 Binding of ACADVL 1 0.23 2.35 0.17 5.00
185 INT218167 Positive_regulation of Gene_expression of ETFDH 1 0.33 1.19 0.15 5.00
186 INT172209 Regulation of HAL 3 0.25 2.23 0.13 5.00
187 INT212996 Negative_regulation of Positive_regulation of Nos3 3 0.35 2.11 0.12 5.00
188 INT188311 Negative_regulation of Regulation of Smc1b 1 0.12 0.56 0.1 5.00
189 INT161127 Localization of SLC22A16 2 0.73 1.34 0.1 5.00
190 INT112328 Negative_regulation of PHKG1 2 0.46 0.83 0.1 5.00
191 INT170744 Positive_regulation of Transcription of Edn1 2 0.20 1.3 0.1 5.00
192 INT309385 Positive_regulation of Phosphorylation of Nos3 5 0.48 2.98 0.09 5.00
193 INT267163 Positive_regulation of Gene_expression of SUGT1 1 0.06 1.48 0.09 5.00
194 INT188304 Positive_regulation of Positive_regulation of Pah 1 0.18 0.75 0.09 5.00
195 INT3492 Negative_regulation of CPT1A 2 0.39 0.24 0.08 5.00
196 INT80667 Gene_expression of PFKM 4 0.57 2.13 0.07 5.00
197 INT153679 Regulation of AGL 4 0.04 1.49 0.07 5.00
198 INT329321 Positive_regulation of Positive_regulation of Tbxa2r 1 0.26 1.76 0.07 5.00
199 INT267169 Positive_regulation of Binding of SUGT1 1 0.06 2.22 0.07 5.00
200 INT343709 Positive_regulation of Negative_regulation of Pde6b 1 0.16 0.87 0.06 5.00
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