D:Cardiovascular Disorder Under Development

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Disease Term
Synonyms Cardiac Abnormalities, Cardiac Abnormality, CARDIAC DISORDER, Cardiac Fibrosis, CARDIAC FIBROTIC CHANGE, CARDIOTOXICITY, Cardiovascular Abnormalities, Cardiovascular Damage, Cardiovascular Depression, Cardiovascular Disease, Cardiovascular Disorder
Documents 1114
Hot Single Events 200
Hot Interactions 13

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Cardiovascular Disorder Under Development. They are ordered first by their relevance to Cardiovascular Disorder Under Development and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT242996 Adipoq Negative_regulation of Transcription of Cd68 1 0.22 0.6 0.21 100.00
2 INT242994 Adipoq Negative_regulation of Spp1 1 0.19 0.59 0.21 100.00
3 INT235697 Binding of Clcn1 and Syn1 1 0.00 0.48 0 99.62
4 INT300305 Mapk14 Positive_regulation of Gene_expression of Ctgf 1 0.19 1.25 0.17 98.68
5 INT277864 Binding of ERBB2 and Ralbp1 1 0.28 0.57 0 96.44
6 INT277863 Binding of ERBB2 and Abcc3 1 0.01 0.28 0 96.44
7 INT242995 Agt Positive_regulation of Spp1 1 0.36 1.82 0.33 94.16
8 INT353872 Binding of KCNH1 and KCNH2 1 0.25 0.98 0 92.48
9 INT353870 Binding of KCNH1 and KCNH2 Negative_regulation of KCNH1 1 0.28 0.98 0 92.48
10 INT353871 Negative_regulation of Binding of KCNH1 and KCNH2 1 0.30 0.98 0 92.48
11 INT235693 Binding of Clcn1 and Gab2 1 0.19 2.96 0 87.00
12 INT242993 Positive_regulation of Ppara Positive_regulation of Gene_expression of Spp1 1 0.24 0.66 0.18 85.76
13 INT235695 Gab2 Positive_regulation of Clcn1 1 0.20 0.52 0 82.32
14 INT279242 Negative_regulation of Binding of GLA and SH3GL3 1 0.08 1.22 0 78.00
15 INT279240 Binding of GLA and SH3GL3 1 0.07 1.21 0 77.12
16 INT352303 Binding of AIF1 and CD68 1 0.01 0.71 0.1 70.56
17 INT341847 ERBB2 Positive_regulation of Gene_expression of ESYT1 1 0.02 1.42 0.03 69.40
18 INT242991 Agt Positive_regulation of Gene_expression of Spp1 1 0.21 0.66 0.26 68.24
19 INT242992 Binding of Agt and Ppara 1 0.20 1.44 0.42 65.08
20 INT310674 Positive_regulation of Binding of ARSB and ELF3 1 0.07 2.46 0.05 62.96
21 INT310675 Binding of ARSB and ELF3 1 0.06 2.4 0.05 62.28
22 INT133825 TNF Negative_regulation of NOS3 1 0.28 0.06 0 61.80
23 INT133824 IL1B Negative_regulation of NOS3 1 0.48 0.06 0 61.24
24 INT300306 Agt Positive_regulation of Mapk14 1 0.14 1.51 0.11 57.12
25 INT182497 IL1B Regulation of Localization of GH1 1 0.00 0.84 0.38 54.96
26 INT182492 IL1B Regulation of Gene_expression of IGF1 1 0.01 0.83 0.38 54.96
27 INT300313 TGFB1 Positive_regulation of Mapk14 1 0.01 1.5 0.11 52.80
28 INT235696 Regulation of Binding of Clcn1 and Gab2 1 0.18 0.32 0 52.00
29 INT315499 Ctnnbl1 Positive_regulation of Ldha 1 0.29 0.26 0 50.96
30 INT257342 Mapk4 Positive_regulation of Gene_expression of Ctgf 1 0.01 0.39 0.08 50.00
31 INT291837 Binding of Pecam1 and Vegfa 1 0.09 1.1 0.07 50.00
32 INT257343 Lox Regulation of Cyba 1 0.02 0.37 0.05 50.00
33 INT257338 Lox Regulation of Cybb 1 0.00 0.37 0.05 50.00
34 INT257339 Lox Regulation of Ncf1 1 0.02 0.37 0.05 50.00
35 INT257344 Gene_expression of Cyba Positive_regulation of Nox1 1 0.23 1.15 0 50.00
36 INT257341 Binding of Neu2 and Cyba 1 0.00 0.29 0 50.00
37 INT257345 Ncf1 Positive_regulation of Gene_expression of Ros1 1 0.08 0.58 0 50.00
38 INT257347 Binding of Cyba and Ncf1 1 0.17 0.29 0 50.00
39 INT257340 Binding of Cyba and Rac1 1 0.09 0.29 0 50.00
40 INT257346 Gene_expression of Lox Positive_regulation of Nox1 1 0.02 0.57 0 50.00
41 INT182489 Gene_expression of AGTR2 Positive_regulation of Gene_expression of AGTR1 1 0.26 0.92 0.4 43.88
42 INT227796 Binding of Acsl1 and Nos3 1 0.16 1.16 0 43.16
43 INT126227 Hsp90aa1 Positive_regulation of Nos1 1 0.03 0.73 0.25 41.24
44 INT297215 Gene_expression of Ppp3ca Positive_regulation of Ppp3r1 1 0.36 0.22 0 40.80
45 INT297212 Gene_expression of Ppp3ca Positive_regulation of Nfatc1 1 0.38 0.22 0 38.56
46 INT101339 ZAK Regulation of Gene_expression of AXL 1 0.01 0.32 0.12 25.00
47 INT251775 AGK Negative_regulation of INSRR 1 0.00 1.1 0.07 22.16
48 INT332685 Trib3 Positive_regulation of Binding of Ros1 1 0.01 0.74 0.12 18.64
49 INT285979 Ros1 Positive_regulation of Trib3 2 0.02 2.18 0.2 15.52
50 INT332687 Ros1 Positive_regulation of Crk 1 0.17 0.77 0.12 14.96
51 INT310412 Binding of CP and TF 1 0.14 1.66 0.13 11.36
52 INT271071 Binding of ACTA1 and Hypism 1 0.00 1.54 0.15 8.80
53 INT84921 Binding of NGF and NTRK1 13 0.50 6.39 6.1 5.00
54 INT127128 Binding of CNR1 and CNR2 8 0.39 3.98 3.97 5.00
55 INT220062 Binding of NGF and TNFRSF1B 1 0.10 2.21 2.81 5.00
56 INT220061 Binding of TRPV1 and TRPA1 1 0.15 1.7 2.69 5.00
57 INT103548 Binding of TRPV1 and TRPV3 3 0.37 1.82 2.28 5.00
58 INT254205 Binding of Myd88 and Tlr4 12 0.19 3.17 1.54 5.00
59 INT220058 NGF Positive_regulation of Gene_expression of BDNF 1 0.12 1.31 1.48 5.00
60 INT220059 NGF Positive_regulation of Positive_regulation of BDNF 1 0.11 1.31 1.48 5.00
61 INT220060 Negative_regulation of Binding of NGF and NTRK1 1 0.08 1.11 1.39 5.00
62 INT105970 GH1 Regulation of Ghsr 1 0.04 1.16 0.84 5.00
63 INT220056 Binding of NTF3 and NTRK1 1 0.07 1.12 0.78 5.00
64 INT220063 Binding of NTF3 and NTRK2 1 0.09 1.13 0.78 5.00
65 INT220057 Binding of NTS and TNFRSF1B 1 0.08 1.23 0.76 5.00
66 INT170558 Binding of Myoc and Narf 1 0.04 3.03 0.63 5.00
67 INT330984 Negative_regulation of CYP2D6 Positive_regulation of Localization of CYP1A2 1 0.46 0 0.62 5.00
68 INT139901 Ins1 Positive_regulation of Akt1 9 0.31 4.58 0.6 5.00
69 INT137141 Binding of HIVEP1 and ITIH4 2 0.16 1.44 0.56 5.00
70 INT144035 IL6 Positive_regulation of STAT3 4 0.31 2.58 0.56 5.00
71 INT351332 Positive_regulation of Il4 Positive_regulation of Gene_expression of Il10 1 0.09 1.78 0.53 5.00
72 INT105971 GH1 Regulation of Ghrl 1 0.03 0.75 0.52 5.00
73 INT285344 Il10 Negative_regulation of Gene_expression of Tnf 1 0.15 1.91 0.49 5.00
74 INT292873 Binding of Fas and Fasl 5 0.26 15.74 0.49 5.00
75 INT241679 EIF2AK3 Positive_regulation of Atf4 1 0.06 0.46 0.4 5.00
76 INT276216 Binding of Akt1 and Ins1 2 0.03 2.61 0.4 5.00
77 INT241614 CCNA2 Regulation of PRB3 1 0.06 0 0.37 5.00
78 INT268225 TBXA2R Positive_regulation of NAAA 1 0.07 0.98 0.35 5.00
79 INT297352 KLF2 Regulation of PPARA 1 0.12 1.31 0.35 5.00
80 INT268224 TBXA2R Positive_regulation of Gene_expression of NAAA 1 0.08 0.98 0.35 5.00
81 INT177426 Izumo1 Positive_regulation of Positive_regulation of Fig4 1 0.16 0.59 0.34 5.00
82 INT297351 EWSR1 Positive_regulation of PPARA 1 0.41 1.81 0.33 5.00
83 INT306323 Tlr4 Positive_regulation of Ticam1 3 0.25 0.55 0.3 5.00
84 INT187361 Binding of Gabrg1 and Kcnn3 1 0.36 0.13 0.3 5.00
85 INT285327 Binding of Cox8b and Gtf2ird2 1 0.00 0.9 0.29 5.00
86 INT222301 Binding of ERBB2 and ESR1 5 0.36 5.07 0.29 5.00
87 INT299956 Binding of PPARA and EPC1 1 0.09 0.34 0.29 5.00
88 INT182499 Binding of AGTR1 and AGTR2 3 0.20 2.79 0.28 5.00
89 INT71904 Binding of ESR1 and PGR 6 0.34 3.79 0.27 5.00
90 INT170560 Binding of Renbp and Narf 1 0.01 1.69 0.27 5.00
91 INT269313 Binding of Ptafr and Gp6 1 0.00 0.48 0.26 5.00
92 INT105966 GH1 Regulation of GHS 1 0.03 0.37 0.25 5.00
93 INT297376 Binding of RARS and Rxra 1 0.01 3.27 0.24 5.00
94 INT325028 TNF Negative_regulation of Ptgs1 1 0.00 1.79 0.23 5.00
95 INT325008 TNF Negative_regulation of Gene_expression of NOSTRIN 1 0.00 1.78 0.23 5.00
96 INT325007 TNF Negative_regulation of NOSTRIN 1 0.00 1.78 0.23 5.00
97 INT177425 Binding of Fig4 and Izumo1 1 0.12 0.59 0.23 5.00
98 INT299155 Smcp Negative_regulation of Spp1 1 0.00 0.7 0.22 5.00
99 INT285341 Mtx1 Regulation of Gene_expression of Tnf 1 0.03 0.78 0.22 5.00
100 INT299156 Smcp Negative_regulation of Tnc 1 0.05 0.7 0.22 5.00
101 INT285340 Mtx1 Regulation of Tnf 1 0.03 0.78 0.22 5.00
102 INT354544 Avp Positive_regulation of ADCY1 1 0.24 2.23 0.22 5.00
103 INT285342 Mtx1 Regulation of Il10 1 0.03 0.78 0.22 5.00
104 INT285343 Mtx1 Regulation of Il6 1 0.04 0.78 0.22 5.00
105 INT299154 Smcp Negative_regulation of Lgals3 1 0.04 0.69 0.22 5.00
106 INT241822 Binding of CD4 and HIVEP1 3 0.01 2.73 0.21 5.00
107 INT252357 Binding of THBS1 and Cd36 2 0.01 2.4 0.21 5.00
108 INT254219 Binding of Myd88 and Tlr2 2 0.16 0.6 0.2 5.00
109 INT351086 Negative_regulation of ERBB2 Positive_regulation of Gene_expression of ESR1 1 0.10 0.75 0.19 5.00
110 INT351089 FOXO3 Positive_regulation of Gene_expression of ESR1 1 0.04 0.74 0.19 5.00
111 INT316203 Ghsr Positive_regulation of Transcription of Agrp 1 0.02 1.5 0.19 5.00
112 INT217661 LEP Positive_regulation of INS 2 0.25 1.85 0.19 5.00
113 INT217665 ADIPOQ Positive_regulation of INS 2 0.06 1.8 0.19 5.00
114 INT126944 Binding of PKD2 and Pkd1 2 0.08 2.09 0.19 5.00
115 INT173430 Binding of FLT4 and VEGFA 10 0.25 9.38 0.19 5.00
116 INT330986 CYP2C9 Positive_regulation of Gene_expression of CYP3A4 1 0.39 0 0.18 5.00
117 INT330985 CYP2C9 Positive_regulation of Gene_expression of CYP2C19 1 0.34 0 0.18 5.00
118 INT351088 Negative_regulation of ERBB2 Positive_regulation of FOXO3 1 0.17 0.66 0.18 5.00
119 INT274386 Binding of CD4 and ERVW-1 1 0.05 3.07 0.18 5.00
120 INT222300 Binding of ERBB2 and PGR 2 0.34 1.89 0.17 5.00
121 INT350363 Gatm Negative_regulation of NOS1 1 0.00 0.31 0.17 5.00
122 INT298641 PPARA Regulation of STAT3 1 0.23 0.98 0.16 5.00
123 INT243524 Positive_regulation of Binding of NTF3 and SOX10 1 0.01 0.54 0.14 5.00
124 INT331628 Binding of HLA-DQA2 and Pain1 1 0.01 2.13 0.14 5.00
125 INT217667 LEP Negative_regulation of Localization of INS 1 0.15 1.18 0.14 5.00
126 INT331627 Binding of HLA-DRB3 and Pain1 1 0.00 2.15 0.14 5.00
127 INT243525 Binding of NTF3 and SOX10 1 0.01 0.54 0.14 5.00
128 INT217664 LEP Negative_regulation of INS 1 0.15 1.18 0.14 5.00
129 INT298639 GDE1 Negative_regulation of AKT1 1 0.00 1.14 0.14 5.00
130 INT332689 Binding of Edn1 and Ros1 1 0.08 0.71 0.14 5.00
131 INT182494 TNF Positive_regulation of OLR1 1 0.05 2.51 0.13 5.00
132 INT175398 Binding of ERBB2 and VEGFA 2 0.16 1.34 0.13 5.00
133 INT182493 HGS Positive_regulation of OLR1 1 0.00 2.51 0.13 5.00
134 INT331612 ETV4 Positive_regulation of Gene_expression of TGFB1 1 0.00 1.32 0.12 5.00
135 INT182496 AGT Positive_regulation of Phosphorylation of STAT3 1 0.03 0.79 0.12 5.00
136 INT341827 Binding of ESR1 and TNC 1 0.14 0.63 0.11 5.00
137 INT294742 Lep Positive_regulation of Localization of Icam1 1 0.15 0.48 0.11 5.00
138 INT299158 Binding of Lgals3 and Renbp 1 0.00 0.64 0.11 5.00
139 INT286683 Gopc Positive_regulation of MBD2 1 0.01 1.07 0.11 5.00
140 INT299955 Binding of KDR and FTSJ3 1 0.04 1.07 0.09 5.00
141 INT249117 Binding of Abl1 and Bcr 4 0.36 2.22 0.09 5.00
142 INT341826 Binding of ERBB2 and TNC 1 0.18 0.63 0.09 5.00
143 INT332688 Ros1 Positive_regulation of Binding of Edn1 1 0.10 0.57 0.09 5.00
144 INT220394 MRXS5 Positive_regulation of Gene_expression of CYP19A1 1 0.00 0.89 0.09 5.00
145 INT299953 Binding of CD34 and FTSJ3 1 0.04 1.07 0.09 5.00
146 INT232559 Map3k1 Positive_regulation of Esr1 1 0.19 0.26 0.09 5.00
147 INT223088 Binding of ELF3 and NAGLU 1 0.14 0.84 0.09 5.00
148 INT257870 Agt Positive_regulation of Akt1 2 0.18 1.5 0.09 5.00
149 INT232557 Erbb2 Positive_regulation of Esr1 1 0.23 0.26 0.09 5.00
150 INT223089 Binding of IDS and NAGLU 1 0.26 0.72 0.09 5.00
151 INT220412 Cpox Positive_regulation of Gene_expression of CYP19A1 1 0.01 0.9 0.09 5.00
152 INT341825 Binding of TNC and PGR 1 0.14 0.63 0.09 5.00
153 INT298634 Binding of IL6 and STAT3 1 0.04 1.41 0.08 5.00
154 INT244640 AGK Negative_regulation of KIT 1 0.00 0.69 0.08 5.00
155 INT251777 Negative_regulation of TXK Positive_regulation of PDGFA 1 0.04 1 0.08 5.00
156 INT244639 AGK Negative_regulation of PDGFRB 1 0.01 0.69 0.08 5.00
157 INT251773 TXK Positive_regulation of PDGFA 1 0.04 1 0.08 5.00
158 INT300304 Positive_regulation of Mapk14 Positive_regulation of Agt 1 0.14 1.5 0.08 5.00
159 INT244638 AGK Negative_regulation of KDR 1 0.00 0.68 0.08 5.00
160 INT294743 Lep Positive_regulation of Transcription of Il6 1 0.18 0.42 0.07 5.00
161 INT294740 Lep Positive_regulation of Transcription of Ccl2 1 0.08 0.42 0.07 5.00
162 INT351651 Enpep Positive_regulation of Agt 1 0.22 0.93 0.07 5.00
163 INT201378 Bdnf Regulation of Gene_expression of Ltp 1 0.00 0.21 0.07 5.00
164 INT331626 Edn1 Positive_regulation of Itk 1 0.00 0.57 0.07 5.00
165 INT351655 Avp Positive_regulation of Agt 1 0.11 0.94 0.07 5.00
166 INT182488 OLR1 Positive_regulation of OLR1 Positive_regulation of Gene_expression of AGTR1 1 0.00 1.27 0.07 5.00
167 INT356379 DMD Positive_regulation of Negative_regulation of Utrn 1 0.54 0.84 0.07 5.00
168 INT331629 Binding of TGFB1 and Positive_regulation of Gene_expression of Itk 1 0.00 0.84 0.07 5.00
169 INT182491 OLR1 Positive_regulation of HGS 1 0.00 1.22 0.07 5.00
170 INT297210 Nfatc1 Regulation of Myoz1 1 0.06 0.51 0.07 5.00
171 INT300308 Positive_regulation of Mapk14 Positive_regulation of Trib3 1 0.03 1.42 0.07 5.00
172 INT300309 Akt1 Regulation of Rorb 1 0.05 3.28 0.06 5.00
173 INT273288 Psen1 Regulation of Prdx2 1 0.01 0.7 0.06 5.00
174 INT251776 Negative_regulation of TXK Negative_regulation of ERBB4 1 0.04 1.07 0.06 5.00
175 INT350482 Tirap Regulation of TICAM2 1 0.05 0.06 0.06 5.00
176 INT350477 Tlr4 Positive_regulation of Positive_regulation of Irf3 1 0.22 0.12 0.06 5.00
177 INT300310 Akt1 Regulation of Foxo3 1 0.21 1.5 0.06 5.00
178 INT297214 Myoz1 Regulation of Gene_expression of Car2 1 0.03 0.5 0.06 5.00
179 INT350481 Tlr4 Positive_regulation of Gene_expression of Myd88 1 0.26 0.06 0.06 5.00
180 INT251774 Negative_regulation of TXK Negative_regulation of EGFR 1 0.07 1.06 0.06 5.00
181 INT244641 PDGFA Regulation of MTOR 1 0.07 2.55 0.06 5.00
182 INT269501 Nos1 Regulation of Lta 1 0.28 0.26 0.05 5.00
183 INT350478 Tirap Regulation of Ticam1 1 0.07 0.06 0.05 5.00
184 INT298638 IL6 Positive_regulation of IL6R 1 0.00 0.9 0.05 5.00
185 INT251778 Negative_regulation of TXK Positive_regulation of KDR 1 0.03 0.99 0.05 5.00
186 INT297211 Negative_regulation of Myoz1 Negative_regulation of Gene_expression of Car2 1 0.03 0.6 0.05 5.00
187 INT279889 Il6 Regulation of Socs3 1 0.21 0.17 0.05 5.00
188 INT217666 ADIPOQ Regulation of Gene_expression of INS 1 0.03 1.99 0.05 5.00
189 INT336132 Binding of AGTR1 and ANG 1 0.00 0.38 0.05 5.00
190 INT298635 PPARA Negative_regulation of Localization of ZDHHC2 1 0.01 0.21 0.05 5.00
191 INT299954 Negative_regulation of LXN Negative_regulation of FTSJ3 1 0.00 0.75 0.05 5.00
192 INT251779 TXK Positive_regulation of KDR 1 0.03 0.99 0.05 5.00
193 INT244328 ELF3 Negative_regulation of Positive_regulation of SH3GL3 3 0.20 1.26 0.04 5.00
194 INT325027 Apoc3 Negative_regulation of Pnlip 1 0.01 1.02 0.04 5.00
195 INT241536 Binding of Abcb1b and Abcg2 1 0.10 0.17 0.04 5.00
196 INT298683 ecs Positive_regulation of Gene_expression of VEGFA 1 0.02 1.41 0.04 5.00
197 INT332684 Binding of Edn1 and Lep 1 0.09 1.11 0.04 5.00
198 INT296893 Nps Negative_regulation of Gene_expression of REN 1 0.00 1.05 0.04 5.00
199 INT213903 Binding of EGFR and ERBB2 10 0.37 5.03 0.04 5.00
200 INT325026 Apoc3 Negative_regulation of Lpl 1 0.03 1.01 0.04 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Cardiovascular Disorder Under Development. They are ordered first by their pain relevance and then by number of times they were reported in Cardiovascular Disorder Under Development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT176517 Negative_regulation of Gene_expression of Spp1 18 0.59 15.31 2.28 100.00
2 INT122901 Positive_regulation of Spp1 67 0.67 58.03 7.49 100.00
3 INT242987 Positive_regulation of Localization of Spp1 3 0.60 7.04 0.59 100.00
4 INT19466 Negative_regulation of Clcn1 6 0.52 3.39 1.22 100.00
5 INT296814 Negative_regulation of Gene_expression of Wbcq1 1 0.03 1.13 0.3 100.00
6 INT296816 Positive_regulation of Gene_expression of Wbcq1 1 0.03 1.13 0.3 100.00
7 INT65211 Binding of Prkcg 38 0.48 14.75 16.92 100.00
8 INT72337 Positive_regulation of Positive_regulation of Nos2 37 0.65 17.02 8.11 99.98
9 INT296806 Positive_regulation of Gene_expression of Scn5a 1 0.50 2.73 0.45 99.98
10 INT284882 Positive_regulation of Scn5a 3 0.50 1.73 0.44 99.98
11 INT110427 Gene_expression of Spp1 199 0.78 176.11 23.31 99.96
12 INT3811 Negative_regulation of PAEP 36 0.50 23.7 5.18 99.96
13 INT7779 Negative_regulation of Adra2a 47 0.58 9.45 28 99.96
14 INT128695 Regulation of Gene_expression of Mapk14 14 0.44 11.49 7.14 99.92
15 INT28021 Positive_regulation of Adipoq 42 0.67 30.79 3.58 99.90
16 INT1952 Negative_regulation of Positive_regulation of Tlr4 33 0.51 15.8 7.41 99.90
17 INT113104 Gene_expression of SCFV 18 0.65 7.13 1.2 99.88
18 INT186593 Gene_expression of SFRP5 1 0.16 3.94 0.46 99.88
19 INT39975 Gene_expression of Thtpa 3 0.00 0.81 0.8 99.88
20 INT296807 Gene_expression of Wbcq1 1 0.04 1.13 0.3 99.84
21 INT1752 Negative_regulation of Ache 109 0.59 42.05 15.73 99.76
22 INT102547 Gene_expression of Cd68 25 0.75 14.47 5.22 99.74
23 INT99070 Gene_expression of Mapk14 147 0.78 103.99 79.59 99.68
24 INT99069 Positive_regulation of Gene_expression of Mapk14 42 0.53 29.84 23.16 99.68
25 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42 99.58
26 INT93129 Negative_regulation of KCNH2 42 0.54 9.63 10.85 99.50
27 INT5297 Regulation of IFNA2 20 0.56 10.81 5.13 99.48
28 INT17879 Positive_regulation of Ppap2a 17 0.53 9.72 3.8 99.44
29 INT291341 Phosphorylation of Ifnar1 2 0.03 0.99 0.22 99.38
30 INT167085 Negative_regulation of ERBB2 67 0.57 44.6 1.48 99.36
31 INT70134 Negative_regulation of TXK 124 0.23 81.96 9.59 99.36
32 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 99.36
33 INT101008 Gene_expression of Scn5a 5 0.75 26.93 6.06 99.28
34 INT89142 Gene_expression of Lox 28 0.67 15.36 5.2 99.24
35 INT242989 Regulation of Gene_expression of Fn1 3 0.10 2.42 0.66 99.24
36 INT117457 Positive_regulation of Gene_expression of Lox 9 0.39 6.97 2.08 99.24
37 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87 99.22
38 INT268844 Positive_regulation of Gene_expression of Pitpnc1 1 0.07 0.57 0 99.18
39 INT12765 Positive_regulation of Phosphorylation of Prkcg 59 0.66 20.16 34.67 99.12
40 INT70724 Positive_regulation of Negative_regulation of ADRB1 1 0.38 0.2 0.86 99.10
41 INT70726 Positive_regulation of Negative_regulation of ADRB2 1 0.49 0.2 0.86 99.10
42 INT285325 Regulation of Coq10a 1 0.29 1.34 0.45 99.04
43 INT268841 Gene_expression of Pitpnc1 1 0.10 1.39 0 98.96
44 INT242990 Transcription of Cd68 2 0.41 1.43 0.55 98.90
45 INT484 Negative_regulation of ADRB2 13 0.59 2.85 3.94 98.86
46 INT115386 Gene_expression of Ppara 779 0.77 549.99 128.36 98.80
47 INT65452 Negative_regulation of Cacna1c 8 0.09 0.8 1.44 98.80
48 INT190611 Gene_expression of Cnn1 13 0.56 5.87 0.75 98.80
49 INT299965 Regulation of EPC1 7 0.23 4.44 0.53 98.78
50 INT87780 Gene_expression of Gja1 22 0.77 5.84 4.24 98.76
51 INT26975 Gene_expression of Adipoq 113 0.75 106.71 14.46 98.66
52 INT146043 Positive_regulation of Gene_expression of Adipoq 39 0.67 29.93 6.12 98.66
53 INT25666 Negative_regulation of ADRB1 11 0.44 3.12 2.33 98.64
54 INT70970 Binding of COPD 144 0.42 180.34 18.29 98.60
55 INT127914 Gene_expression of AGTR2 23 0.68 26.87 4.69 98.52
56 INT60568 Negative_regulation of Mtx1 5 0.38 3.6 2.87 98.52
57 INT39758 Gene_expression of Fn1 57 0.65 34.38 6.02 98.44
58 INT291342 Negative_regulation of Mpeg1 3 0.40 5.76 0.2 98.44
59 INT268847 Binding of Top2a 2 0.24 0.6 0 98.28
60 INT83006 Gene_expression of AGTR1 59 0.75 54.46 7.27 98.20
61 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 98.12
62 INT158296 Positive_regulation of Gene_expression of Ctgf 5 0.47 4.82 0.47 98.10
63 INT268846 Negative_regulation of Top2a 6 0.29 3.06 0.07 98.08
64 INT103260 Positive_regulation of Nps 35 0.48 23.8 5.67 98.08
65 INT91703 Negative_regulation of Myoz1 78 0.58 53.78 13.5 98.04
66 INT16395 Gene_expression of CEBPZ 30 0.57 11.02 6.66 97.96
67 INT324672 Negative_regulation of Gene_expression of CEBPZ 2 0.36 2.75 0.48 97.96
68 INT140091 Gene_expression of Ctgf 26 0.78 14.21 2.39 97.90
69 INT76752 Negative_regulation of TOP2B 8 0.42 6.2 0.14 97.76
70 INT176516 Localization of Spp1 28 0.76 19.39 1.9 97.64
71 INT86780 Positive_regulation of Hmox1 145 0.70 117.09 31.18 97.64
72 INT12003 Gene_expression of Ang 4 0.64 3.87 0.44 97.60
73 INT112704 Positive_regulation of Hif1a 25 0.67 21.49 4.23 97.40
74 INT3578 Negative_regulation of TPR 7 0.42 4.18 2.41 97.32
75 INT81293 Positive_regulation of Gene_expression of Hmox1 53 0.70 41.54 7.25 97.28
76 INT27933 Gene_expression of NCOR2 65 0.72 31.35 24.23 97.24
77 INT88182 Gene_expression of Atp2a2 40 0.78 22.91 4.26 97.20
78 INT99427 Positive_regulation of Gene_expression of Atp2a2 5 0.64 4.13 1.14 97.20
79 INT251799 Negative_regulation of HUWE1 1 0.01 0.88 0.09 97.16
80 INT1303 Negative_regulation of Npr1 278 0.55 35.1 156.78 96.96
81 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 96.96
82 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 96.92
83 INT1179 Negative_regulation of Ace 157 0.59 67.03 30.46 96.92
84 INT50670 Gene_expression of CPOX 763 0.76 442.13 195.02 96.92
85 INT174688 Binding of Tlr2 45 0.42 36.65 5.25 96.88
86 INT70721 Negative_regulation of SRRT 1 0.09 0.19 0.91 96.84
87 INT171070 Positive_regulation of Hey2 8 0.05 10.12 1.96 96.80
88 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 96.80
89 INT173159 Localization of PPARA 96 0.74 64.55 10.26 96.68
90 INT111195 Negative_regulation of Gene_expression of Agtr1a 7 0.58 3.2 3.16 96.64
91 INT16960 Gene_expression of Crp 166 0.76 116.21 34.07 96.56
92 INT26996 Positive_regulation of Gene_expression of Crp 21 0.68 21.55 2.75 96.56
93 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18 96.50
94 INT14733 Positive_regulation of Gene_expression of TGFB1 71 0.69 49.89 22.2 96.50
95 INT159127 Gene_expression of Nps 49 0.75 16.91 12.06 96.48
96 INT122902 Positive_regulation of Gene_expression of Spp1 54 0.70 56.3 6.33 96.40
97 INT5511 Negative_regulation of Gene_expression of Pomc 47 0.59 12.08 23.02 96.28
98 INT940 Negative_regulation of Ptgs1 219 0.59 104.34 95.97 96.20
99 INT6906 Negative_regulation of SCN5A 64 0.43 20.64 7.3 96.20
100 INT14731 Positive_regulation of TGFB1 78 0.67 52.57 22.23 96.18
101 INT269264 Regulation of Mt1 6 0.21 2.71 0.2 96.16
102 INT269262 Positive_regulation of Regulation of Mt1 1 0.23 0.62 0.04 96.16
103 INT84546 Positive_regulation of Ppara 481 0.70 334.21 83.45 96.14
104 INT12537 Positive_regulation of Localization of Prkcg 36 0.70 14.57 33.81 96.04
105 INT17086 Binding of HSD11B1 84 0.47 122.28 6.16 95.92
106 INT51921 Gene_expression of Cpox 501 0.73 229.81 157.81 95.92
107 INT53949 Positive_regulation of Gene_expression of Cpox 82 0.65 38.12 25.93 95.92
108 INT131112 Phosphorylation of Casp3 7 0.63 4.1 2.46 95.88
109 INT76406 Gene_expression of Hmox1 140 0.78 85.86 17.15 95.80
110 INT22083 Regulation of Pth 55 0.62 22.32 8.9 95.76
111 INT35486 Regulation of PTGER2 39 0.36 19.03 6.75 95.76
112 INT12536 Localization of Prkcg 101 0.80 36.37 73.81 95.72
113 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 95.60
114 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 95.60
115 INT284878 Regulation of Scn5a 2 0.27 1.15 0.09 95.60
116 INT957 Positive_regulation of GHRH 136 0.70 36.84 40.52 95.52
117 INT69698 Binding of Ctnnbl1 2 0.22 0.76 0.36 95.52
118 INT25271 Positive_regulation of MTG1 21 0.67 13.59 5.96 95.48
119 INT9550 Gene_expression of TNNI3 113 0.78 86.79 10.56 95.44
120 INT102146 Phosphorylation of Bax 4 0.66 3.48 2.35 95.44
121 INT242988 Positive_regulation of Transcription of Spp1 4 0.28 3.28 0.92 95.36
122 INT123877 Negative_regulation of ABL1 40 0.57 27.94 1.17 95.28
123 INT300291 Phosphorylation of Sirt1 1 0.77 6.07 0.45 95.24
124 INT12763 Phosphorylation of Prkcg 167 0.82 38.91 89.63 95.20
125 INT39587 Gene_expression of CP 42 0.65 31.48 11.87 95.08
126 INT3529 Regulation of GOT1 6 0.52 2.4 1.01 94.96
127 INT197485 Regulation of Positive_regulation of GOT1 1 0.01 0.44 0.04 94.96
128 INT197486 Positive_regulation of Regulation of GOT1 1 0.01 0.44 0.04 94.96
129 INT176513 Transcription of Spp1 5 0.63 4.32 0.67 94.88
130 INT812 Localization of INS 1026 0.81 515.6 145.31 94.80
131 INT2274 Regulation of Localization of INS 101 0.62 41.55 34.79 94.80
132 INT29368 Binding of ECT 25 0.41 11.65 5.81 94.72
133 INT4097 Localization of Pth 66 0.81 47.17 4.36 94.56
134 INT79703 Gene_expression of Agtr1a 46 0.76 14.18 13.77 94.52
135 INT11121 Positive_regulation of NPPA 64 0.70 34.09 11.96 94.52
136 INT20631 Positive_regulation of CHKB 166 0.69 109.86 17.92 94.52
137 INT54167 Negative_regulation of Positive_regulation of NPPA 4 0.42 1.26 0.63 94.52
138 INT189750 Negative_regulation of Positive_regulation of CHKB 4 0.26 2.36 0.38 94.52
139 INT2630 Positive_regulation of Shbg 134 0.70 65.26 15.19 94.44
140 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 94.40
141 INT1278 Negative_regulation of Ldha 93 0.59 37.66 19.36 94.36
142 INT53950 Phosphorylation of Tp53 8 0.61 9.4 0.6 94.36
143 INT356391 Negative_regulation of Gene_expression of Fli1 1 0.09 1.54 0.14 94.32
144 INT336136 Negative_regulation of PHB2 1 0.08 1.01 0.09 94.24
145 INT886 Gene_expression of Pomc 676 0.78 129.87 295.98 94.20
146 INT84427 Positive_regulation of Gene_expression of TSPO 15 0.64 5.05 3.58 94.12
147 INT97701 Phosphorylation of Mapk14 191 0.82 115.33 100.46 94.08
148 INT97702 Positive_regulation of Phosphorylation of Mapk14 69 0.69 49.21 36.81 94.08
149 INT117713 Phosphorylation of Akt1 275 0.82 95.82 54.34 94.04
150 INT281594 Phosphorylation of Foxo3 3 0.67 21.16 0.95 94.04
151 INT356389 Gene_expression of Fli1 1 0.13 1.53 0.13 93.80
152 INT269260 Regulation of Gene_expression of Mecr 1 0.62 2.19 0.04 93.68
153 INT17470 Negative_regulation of NDUFC1 3 0.05 3.43 0.75 93.64
154 INT79915 Positive_regulation of Agt 27 0.56 12.97 1.96 93.52
155 INT39170 Gene_expression of TSPO 76 0.78 24.11 8.05 93.48
156 INT62950 Gene_expression of NPPB 73 0.75 65.91 6.54 93.20
157 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 93.20
158 INT99426 Negative_regulation of Gene_expression of Atp2a2 19 0.59 13.7 1.96 93.12
159 INT101147 Gene_expression of Uchl1 31 0.76 14.73 13.22 93.12
160 INT91147 Positive_regulation of Positive_regulation of Ppara 30 0.69 19.31 5.56 93.04
161 INT236104 Positive_regulation of Negative_regulation of Ppara 6 0.59 6.91 0.91 93.00
162 INT10534 Positive_regulation of Trib3 209 0.60 78.75 81.48 92.80
163 INT181194 Regulation of Gene_expression of PPARA 31 0.44 21.27 5.96 92.80
164 INT48891 Positive_regulation of Il10 143 0.70 101.42 56.72 92.72
165 INT2323 Gene_expression of Trh 146 0.78 29.92 49.5 92.64
166 INT183425 Negative_regulation of Protein_catabolism of Pde2a 1 0.09 0.84 0.05 92.64
167 INT269254 Gene_expression of Mecr 1 0.78 10.69 0.14 92.56
168 INT269253 Positive_regulation of Gene_expression of Mecr 1 0.70 6.95 0.06 92.56
169 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 92.52
170 INT9131 Positive_regulation of Prkcg 431 0.70 130.8 302.41 92.40
171 INT9525 Regulation of Positive_regulation of Prkcg 20 0.62 7.82 16.18 92.40
172 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91 92.36
173 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 92.32
174 INT235679 Negative_regulation of Positive_regulation of Gab2 1 0.36 0.44 0 92.24
175 INT16129 Positive_regulation of Binding of GNRH1 4 0.40 4.37 0.63 92.16
176 INT72060 Positive_regulation of Gene_expression of Ros1 127 0.41 76.76 20.91 92.16
177 INT183439 Protein_catabolism of Pde2a 1 0.14 0.84 0.05 92.08
178 INT52962 Binding of ERBB2 77 0.47 50.03 1.49 92.04
179 INT9781 Binding of INSRR 64 0.31 19.1 25.2 92.04
180 INT4369 Gene_expression of Ldha 157 0.76 88.12 22.45 91.84
181 INT3920 Localization of Ldha 241 0.81 83.08 58.72 91.84
182 INT143459 Negative_regulation of Ddx39b 1 0.17 0.57 0.59 91.84
183 INT23598 Binding of SCN5A 32 0.40 16 5.35 91.84
184 INT286676 Positive_regulation of Regulation of Maob 1 0.40 1.32 0.23 91.84
185 INT91247 Binding of PIRT 1 0.01 0.09 0.18 91.84
186 INT9973 Binding of MMVP1 14 0.48 22.66 1.79 91.76
187 INT86602 Binding of KCNH2 14 0.36 4.65 2.58 91.64
188 INT9246 Positive_regulation of Cat 113 0.70 52.73 18.04 91.60
189 INT258759 Regulation of Localization of ADHD1 3 0.38 4.71 0.32 91.56
190 INT182513 Regulation of AGTR2 4 0.14 4.31 0.91 91.52
191 INT55344 Gene_expression of Ros1 396 0.54 217.64 59.98 91.44
192 INT301438 Negative_regulation of Smyd2 1 0.58 0.73 0.05 91.44
193 INT5135 Negative_regulation of GNRH1 106 0.58 36.63 27.71 91.40
194 INT17996 Binding of Crp 40 0.37 31.4 7.8 91.36
195 INT143460 Negative_regulation of Cybb 2 0.43 3.12 1.86 91.32
196 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 91.32
197 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 91.28
198 INT235682 Binding of Gab2 1 0.41 2.37 0.13 91.20
199 INT235687 Positive_regulation of Gab2 1 0.59 1.52 0.63 91.20
200 INT12681 Regulation of Trib3 76 0.53 23.92 26.58 91.20
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