D:Carotid Artery Diseases

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Disease Term
Synonyms Arterial Disease Carotid, Arterial Diseases Carotid, ARTERIAL DISEASES COMMON CAROTID, Arterial Diseases External Carotid, Arterial Diseases Internal Carotid, ARTERY DISEASE CAROTID, Artery Diseases Carotid, Artery Disorder Carotid, Artery Disorders Carotid, Atherosclerotic Disease Carotid, Atherosclerotic Diseases Carotid
Documents 92
Hot Single Events 13
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Carotid Artery Diseases. They are ordered first by their relevance to Carotid Artery Diseases and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT213263 INS Positive_regulation of EDN1 1 0.12 0.54 0.04 45.92
2 INT278292 Binding of CRP and ESR1 6 0.09 10.92 0.96 5.00
3 INT105435 TNF Positive_regulation of IL6 5 0.25 4.45 0.83 5.00
4 INT342457 CSF1 Negative_regulation of Gene_expression of CCR4 1 0.00 0.93 0.31 5.00
5 INT342458 CSF1 Positive_regulation of Gene_expression of CCL2 1 0.17 0.84 0.27 5.00
6 INT342456 AGT Positive_regulation of Gene_expression of CCL2 1 0.07 0.63 0.25 5.00
7 INT226073 Binding of CRP and SHBG 2 0.10 2.14 0.24 5.00
8 INT353861 Binding of Mgp and Phdlc1 1 0.01 5.09 0.16 5.00
9 INT342459 CXCR3 Positive_regulation of CRTC1 1 0.00 0.59 0.11 5.00
10 INT213261 TNF Positive_regulation of CRP 1 0.24 1.59 0.06 5.00
11 INT213262 IL6 Positive_regulation of CYP19A1 1 0.11 1.63 0.03 5.00
12 INT353865 Binding of CHI3L1 and Lepr 1 0.00 1.88 0.03 5.00
13 INT278291 Binding of CRP and DBP 1 0.12 1.57 0.03 5.00
14 INT278289 Binding of DBP and ESR1 1 0.03 0.82 0.03 5.00
15 INT278294 Binding of ESR1 and SHBG 1 0.01 0.82 0.03 5.00
16 INT278290 Binding of CRP and PADI4 1 0.11 1.2 0.03 5.00
17 INT278295 DBP Positive_regulation of SHBG 1 0.02 0.92 0 5.00
18 INT278293 Binding of DBP and SHBG 2 0.02 1.34 0 5.00
19 INT180294 Positive_regulation of Binding of CPB1 and S100B 1 0.09 0 0 5.00
20 INT180295 Binding of CPB1 and S100B 1 0.08 0 0 5.00
21 INT180302 Positive_regulation of Binding of S100B and Tg(EGFR)0Jlj 1 0.05 0 0 5.00
22 INT180303 Binding of S100B and Tg(EGFR)0Jlj 1 0.03 0 0 5.00
23 INT256400 GLP1R Positive_regulation of Localization of GCG 1 0.02 0.15 0 5.00
24 INT213264 INS Positive_regulation of Localization of IGF1 1 0.16 1.77 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Carotid Artery Diseases. They are ordered first by their pain relevance and then by number of times they were reported in Carotid Artery Diseases. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT160568 Positive_regulation of PADI4 7 0.45 10.5 0.41 97.56
2 INT86184 Negative_regulation of Acsl1 10 0.34 20.45 2.23 96.16
3 INT262109 Positive_regulation of Mgp 2 0.63 42.44 0.9 94.96
4 INT353857 Positive_regulation of Positive_regulation of Mgp 1 0.40 2.61 0.04 94.96
5 INT2330 Regulation of CB 78 0.10 20.46 32.6 94.92
6 INT322081 Positive_regulation of Abcd2 1 0.38 2.29 0.2 94.84
7 INT353854 Positive_regulation of Gene_expression of Mgp 1 0.63 13.92 0.73 94.32
8 INT353859 Positive_regulation of Binding of Mgp 1 0.37 2.89 0.04 94.32
9 INT337100 Gene_expression of Mgp 3 0.71 45.04 1.64 93.36
10 INT180497 Binding of MRI1 45 0.42 28.35 14.77 93.16
11 INT353858 Binding of Mgp 1 0.38 7.16 0.11 90.56
12 INT75869 Gene_expression of Acsl1 24 0.45 27.76 3.66 84.88
13 INT671 Positive_regulation of Cea 221 0.69 164.5 47.79 84.52
14 INT126672 Binding of Bcar1 7 0.20 2.67 0.98 77.24
15 INT10863 Positive_regulation of Ldlr 45 0.68 31.06 7.05 72.92
16 INT25402 Binding of Ptcra 10 0.34 3.54 1.85 63.40
17 INT304778 Regulation of SCARF2 1 0.05 0.53 0 62.48
18 INT178890 Localization of CHDH 12 0.62 15.76 1.49 62.04
19 INT61378 Positive_regulation of Bcar1 13 0.45 2.84 2.45 56.16
20 INT14086 Binding of SERPINB1 18 0.34 4.32 3.13 53.36
21 INT20622 Gene_expression of LDHA 107 0.76 77.97 16.3 52.80
22 INT20633 Positive_regulation of Gene_expression of LDHA 15 0.49 15.94 1.42 52.80
23 INT178888 Gene_expression of CHDH 41 0.65 38.66 2.51 43.88
24 INT17742 Localization of S100B 44 0.80 17.14 4.65 41.92
25 INT229750 Positive_regulation of Gene_expression of CHDH 9 0.30 9.38 0.03 41.76
26 INT17182 Binding of Cea 25 0.48 14.98 4.16 41.68
27 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 35.08
28 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 35.08
29 INT242921 Positive_regulation of Aoc2-ps1 1 0.12 1.82 0.04 34.00
30 INT55619 Binding of Acsl1 8 0.31 9.91 1.22 28.96
31 INT39407 Binding of OLR1 18 0.48 14.79 2.51 22.76
32 INT16214 Localization of F13A1 36 0.74 21.8 4.87 20.88
33 INT304779 Positive_regulation of ACADS 1 0.50 1.1 0.12 15.20
34 INT14916 Binding of RASA1 15 0.37 13.64 1.44 13.04
35 INT158 Localization of Prl 2431 0.81 378.96 952.2 5.00
36 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 5.00
37 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
38 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
39 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
40 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 5.00
41 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02 5.00
42 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
43 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
44 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
45 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
46 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
47 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
48 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
49 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
50 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 5.00
51 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 5.00
52 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.00
53 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
54 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 5.00
55 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 5.00
56 INT6477 Gene_expression of IL1RN 213 0.77 114.69 58.62 5.00
57 INT46637 Gene_expression of CXCL10 172 0.78 121.94 57.74 5.00
58 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 5.00
59 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
60 INT251 Regulation of INS 398 0.62 232.47 55.04 5.00
61 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
62 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 5.00
63 INT81498 Positive_regulation of Gene_expression of CCL2 107 0.70 53.89 45.22 5.00
64 INT16364 Gene_expression of HLA-DRA 234 0.78 118.81 45.01 5.00
65 INT2774 Binding of Crp 241 0.48 195.89 44.39 5.00
66 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 5.00
67 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 5.00
68 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 5.00
69 INT104392 Gene_expression of Cxcl10 113 0.75 106.86 34.12 5.00
70 INT16960 Gene_expression of Crp 166 0.76 116.21 34.07 5.00
71 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 5.00
72 INT65698 Localization of CCL2 118 0.81 77.54 32.69 5.00
73 INT62830 Gene_expression of VCAM1 149 0.78 125.23 32.4 5.00
74 INT121663 Gene_expression of CXCR3 76 0.77 50.96 30.62 5.00
75 INT100861 Binding of CRP 179 0.48 175.2 26.45 5.00
76 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 5.00
77 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 5.00
78 INT17625 Localization of GCG 210 0.80 55.69 24.97 5.00
79 INT58192 Positive_regulation of MRI1 86 0.61 53.81 24.68 5.00
80 INT58288 Positive_regulation of Gene_expression of Crp 83 0.61 82.23 23.7 5.00
81 INT94335 Positive_regulation of CXCL10 71 0.58 50.69 23 5.00
82 INT8640 Positive_regulation of HSD11B1 332 0.67 377.84 22.36 5.00
83 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91 5.00
84 INT10442 Negative_regulation of CNR1 47 0.59 20.88 20.2 5.00
85 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44 5.00
86 INT192409 Positive_regulation of Gene_expression of IFN1@ 102 0.67 64.66 18.8 5.00
87 INT80755 Gene_expression of CD40 88 0.75 53.68 17.86 5.00
88 INT84464 Gene_expression of DPP4 101 0.78 56.15 17.53 5.00
89 INT38056 Localization of Crp 71 0.78 53.14 17.03 5.00
90 INT10834 Binding of IL8 65 0.48 41.66 16.53 5.00
91 INT62681 Negative_regulation of LEP 93 0.59 66.97 15.77 5.00
92 INT170335 Gene_expression of INCENP 176 0.54 91.62 15.31 5.00
93 INT5333 Gene_expression of NPEPPS 45 0.65 26.34 15.25 5.00
94 INT75540 Positive_regulation of TH1L 62 0.67 43.45 15.02 5.00
95 INT505 Positive_regulation of GPT 89 0.67 69.38 14.94 5.00
96 INT11636 Positive_regulation of SERPINE1 85 0.69 68.73 14.8 5.00
97 INT100139 Positive_regulation of Gene_expression of PPARA 160 0.63 97.78 14.53 5.00
98 INT11340 Positive_regulation of SLC17A5 120 0.67 113.52 14.5 5.00
99 INT91544 Gene_expression of CHI3L1 60 0.75 77.72 13.9 5.00
100 INT17565 Regulation of Gpt 85 0.60 43.64 13.68 5.00
101 INT14572 Binding of INS 205 0.48 175.43 13.38 5.00
102 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83 5.00
103 INT32203 Negative_regulation of Crp 48 0.58 32.77 11.89 5.00
104 INT1735 Gene_expression of HSD11B1 199 0.75 257.87 11.5 5.00
105 INT94438 Gene_expression of OLR1 86 0.78 80.38 11.03 5.00
106 INT4605 Negative_regulation of Gene_expression of INS 220 0.58 139.66 10.75 5.00
107 INT1734 Negative_regulation of HSD11B1 116 0.57 125.13 10.52 5.00
108 INT144391 Gene_expression of RETN 42 0.75 40.48 10.47 5.00
109 INT167964 Gene_expression of Aes 30 0.58 25.41 10.16 5.00
110 INT170333 Binding of IFN1@ 68 0.47 49.01 9.72 5.00
111 INT132036 Negative_regulation of DPP4 126 0.59 63.24 9.51 5.00
112 INT26492 Negative_regulation of Localization of GCG 73 0.58 22.2 9.48 5.00
113 INT64346 Positive_regulation of S100B 95 0.70 63.11 9.17 5.00
114 INT20664 Binding of ACE 60 0.48 35.27 9.16 5.00
115 INT2139 Negative_regulation of Cea 55 0.43 43.59 9.14 5.00
116 INT1118 Gene_expression of C6orf25 73 0.77 47.24 9.1 5.00
117 INT34777 Localization of IGF1 82 0.80 42.68 8.62 5.00
118 INT22383 Binding of IL2 59 0.48 39.06 8.56 5.00
119 INT75907 Binding of LEP 53 0.46 46.65 8.44 5.00
120 INT162393 Gene_expression of SMUG1 58 0.75 38.78 7.7 5.00
121 INT153300 Negative_regulation of Gene_expression of CRP 48 0.58 39.97 7.58 5.00
122 INT65489 Regulation of Gene_expression of Crp 28 0.59 29.17 7.56 5.00
123 INT93003 Binding of CD40 28 0.47 20.25 7.13 5.00
124 INT32709 Negative_regulation of Hbb 30 0.54 18.27 6.97 5.00
125 INT36053 Positive_regulation of Positive_regulation of IL1B 22 0.70 11.41 6.84 5.00
126 INT16068 Gene_expression of SERPINB1 27 0.60 20.51 6.56 5.00
127 INT171749 Positive_regulation of Gene_expression of CXCR3 18 0.58 11.03 6.51 5.00
128 INT11826 Positive_regulation of LDLR 62 0.62 45.09 6.21 5.00
129 INT137454 Gene_expression of ADIPOQ 88 0.78 85.32 6.2 5.00
130 INT2137 Localization of Cea 27 0.70 19.22 6.14 5.00
131 INT4144 Gene_expression of SHBG 64 0.68 39.94 6.08 5.00
132 INT11360 Localization of SERPINE1 41 0.80 33.98 5.61 5.00
133 INT65356 Localization of LEP 46 0.79 41.17 5.43 5.00
134 INT74614 Positive_regulation of Apoa1 16 0.68 23.95 5.04 5.00
135 INT4146 Binding of SHBG 49 0.47 31 4.71 5.00
136 INT171011 Localization of RETN 12 0.73 19.2 4.64 5.00
137 INT125884 Positive_regulation of CHI3L1 15 0.62 34.04 4.43 5.00
138 INT9098 Positive_regulation of DBP 30 0.69 15.77 4.26 5.00
139 INT146355 Negative_regulation of Aes 15 0.51 7.83 4.25 5.00
140 INT104221 Regulation of Gene_expression of CRP 30 0.45 20.01 4.07 5.00
141 INT89394 Phosphorylation of INS 37 0.82 35.84 3.9 5.00
142 INT34720 Positive_regulation of SHBG 58 0.69 32.4 3.83 5.00
143 INT83431 Binding of ADIPOQ 35 0.48 33.63 3.83 5.00
144 INT83433 Positive_regulation of ADIPOQ 40 0.69 34 3.67 5.00
145 INT12598 Binding of DBP 20 0.48 13.11 3.62 5.00
146 INT137180 Binding of CXCR3 10 0.41 4.24 3.53 5.00
147 INT237054 Negative_regulation of Gene_expression of Cxcl10 11 0.56 10.26 3.4 5.00
148 INT207449 Negative_regulation of OLR1 23 0.42 17.17 3.37 5.00
149 INT182233 Gene_expression of CCR4 14 0.43 6.55 3.31 5.00
150 INT70958 Binding of NOS3 19 0.37 11.84 3.29 5.00
151 INT107514 Positive_regulation of Akr1b1 6 0.70 7.64 3.21 5.00
152 INT66191 Gene_expression of DBP 42 0.66 22.25 3.18 5.00
153 INT164633 Gene_expression of EGFL7 23 0.53 10.46 3.1 5.00
154 INT550 Negative_regulation of LDLR 66 0.43 44.71 3.04 5.00
155 INT102233 Gene_expression of MMP7 40 0.76 15.78 2.93 5.00
156 INT32623 Negative_regulation of Regulation of INS 16 0.43 10.96 2.9 5.00
157 INT77602 Binding of VCAM1 8 0.41 8.66 2.86 5.00
158 INT131929 Positive_regulation of Gene_expression of S100B 25 0.67 12.61 2.83 5.00
159 INT170557 Gene_expression of Lepr 16 0.67 17.26 2.78 5.00
160 INT204340 Localization of ADIPOQ 20 0.75 25.18 2.64 5.00
161 INT125885 Positive_regulation of Gene_expression of CHI3L1 8 0.49 10.8 2.64 5.00
162 INT23775 Regulation of S100B 24 0.62 16.75 2.57 5.00
163 INT134811 Gene_expression of ICA1 22 0.44 6.47 2.42 5.00
164 INT132419 Positive_regulation of ANXA5 9 0.59 5.22 2.38 5.00
165 INT125138 Positive_regulation of RETN 13 0.67 11.94 2.34 5.00
166 INT28486 Positive_regulation of Phdlc1 18 0.40 14.4 2.17 5.00
167 INT43900 Gene_expression of RASA1 13 0.58 12 2.03 5.00
168 INT45176 Negative_regulation of LPL 34 0.59 22.22 2.01 5.00
169 INT158022 Binding of CHI3L1 10 0.43 14.18 1.94 5.00
170 INT14182 Gene_expression of CPB1 26 0.67 10.06 1.9 5.00
171 INT28173 Localization of DBP 8 0.73 3.4 1.83 5.00
172 INT58563 Negative_regulation of S100B 13 0.51 11.75 1.77 5.00
173 INT217070 Gene_expression of Acsm3 8 0.25 6.27 1.75 5.00
174 INT10207 Gene_expression of PADI4 22 0.75 23.49 1.74 5.00
175 INT143850 Gene_expression of S100a1 19 0.73 9.52 1.54 5.00
176 INT178889 Negative_regulation of CHDH 38 0.48 36.69 1.53 5.00
177 INT242212 Gene_expression of GLP1R 29 0.65 11.36 1.52 5.00
178 INT93350 Binding of Lepr 17 0.05 27.21 1.5 5.00
179 INT187411 Gene_expression of Cd320 23 0.75 12.1 1.39 5.00
180 INT51064 Regulation of Gene_expression of S100B 13 0.60 5.02 1.34 5.00
181 INT155007 Positive_regulation of Gene_expression of RETN 4 0.27 9.17 1.3 5.00
182 INT62896 Binding of NOSTRIN 4 0.30 2.86 1.3 5.00
183 INT19635 Localization of SHBG 7 0.78 2.83 1.29 5.00
184 INT145312 Localization of CHI3L1 8 0.78 12.71 1.26 5.00
185 INT145960 Positive_regulation of GLP1R 19 0.58 7.25 1.19 5.00
186 INT224415 Gene_expression of CIMT 28 0.57 12.35 1.15 5.00
187 INT213277 Positive_regulation of Gene_expression of ADIPOQ 14 0.50 17.7 1.14 5.00
188 INT161706 Negative_regulation of Gene_expression of S100B 8 0.43 2.69 1.06 5.00
189 INT228770 Gene_expression of amd 16 0.57 21.49 1.05 5.00
190 INT217341 Negative_regulation of Gene_expression of CXCL10 6 0.25 4.97 1.04 5.00
191 INT51066 Binding of S100B 24 0.48 13.5 0.97 5.00
192 INT115069 Positive_regulation of Localization of Cea 5 0.34 3.31 0.95 5.00
193 INT80296 Gene_expression of CCL7 4 0.43 1.65 0.93 5.00
194 INT185837 Regulation of Gene_expression of MMP7 6 0.44 2.87 0.92 5.00
195 INT102988 Regulation of CHI3L1 5 0.48 7.23 0.86 5.00
196 INT124210 Negative_regulation of CHI3L1 7 0.12 4.39 0.85 5.00
197 INT122811 Binding of Ecd 11 0.31 3.01 0.84 5.00
198 INT191926 Negative_regulation of Lepr 13 0.48 17.68 0.8 5.00
199 INT180300 Positive_regulation of Positive_regulation of S100B 3 0.50 2.07 0.79 5.00
200 INT84979 Regulation of CHDH 22 0.38 22.34 0.78 5.00
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