D:Carotid Stenosis

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Disease Term
Synonyms ARTERY NARROWING CAROTID, ARTERY NARROWINGS CAROTID, Artery Plaque Carotid, Artery Plaques Carotid, Artery Stenoses Carotid, Artery Stenosis Carotid, Carotid Artery Narrowing, CAROTID ARTERY NARROWINGS, Carotid Artery Plaque, Carotid Artery Plaques, Carotid Artery Stenoses
Documents 154
Hot Single Events 35
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Carotid Stenosis. They are ordered first by their relevance to Carotid Stenosis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT270789 CRP Negative_regulation of Gene_expression of TNF 1 0.34 0.87 0.36 50.00
2 INT254855 Agt Positive_regulation of Tgfb1 1 0.03 0.18 0.13 48.96
3 INT353836 Binding of CEACAM7 and ICA1 1 0.08 0.32 0.39 5.00
4 INT342457 CSF1 Negative_regulation of Gene_expression of CCR4 1 0.00 0.93 0.31 5.00
5 INT342458 CSF1 Positive_regulation of Gene_expression of CCL2 1 0.17 0.84 0.27 5.00
6 INT342456 AGT Positive_regulation of Gene_expression of CCL2 1 0.07 0.63 0.25 5.00
7 INT342459 CXCR3 Positive_regulation of CRTC1 1 0.00 0.59 0.11 5.00
8 INT337118 MCRS1 Negative_regulation of C7orf49 1 0.00 0.66 0.04 5.00
9 INT254860 Ctgf Negative_regulation of Col7a1 1 0.00 0.51 0.03 5.00
10 INT254852 Binding of Col7a1 and Smad3 1 0.01 0.57 0.03 5.00
11 INT254867 Ctgf Negative_regulation of Serpine1 1 0.04 0.51 0.03 5.00
12 INT254849 Negative_regulation of Rhoa Positive_regulation of Phosphorylation of Smad3 1 0.11 0.45 0 5.00
13 INT254866 Positive_regulation of C3 Negative_regulation of Rock1 1 0.02 0 0 5.00
14 INT254851 C3 Negative_regulation of Rhoa 1 0.06 0 0 5.00
15 INT254848 Tgfb1 Negative_regulation of Rhoa 1 0.02 0 0 5.00
16 INT254863 Tgfb1 Positive_regulation of Transcription of Smad3 1 0.03 0.23 0 5.00
17 INT254854 Positive_regulation of C3 Negative_regulation of Rhoa 1 0.05 0 0 5.00
18 INT254847 Rac1 Positive_regulation of Fbrs 1 0.09 0.81 0 5.00
19 INT254861 C3 Negative_regulation of Rock1 1 0.02 0 0 5.00
20 INT254857 Tgfb1 Positive_regulation of Phosphorylation of Smad3 1 0.03 0.44 0 5.00
21 INT254865 Rhoa Positive_regulation of Fbrs 1 0.08 0.81 0 5.00
22 INT256400 GLP1R Positive_regulation of Localization of GCG 1 0.02 0.15 0 5.00
23 INT254864 Rhoa Positive_regulation of Egfl7 1 0.02 0.82 0 5.00
24 INT227796 Binding of Acsl1 and Nos3 1 0.16 1.16 0 5.00
25 INT254856 Tgfb1 Negative_regulation of Rock1 1 0.01 0 0 5.00
26 INT254853 Rhoa Positive_regulation of Rac1 1 0.10 0.81 0 5.00
27 INT254850 Setd1a Negative_regulation of Rac1 1 0.00 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Carotid Stenosis. They are ordered first by their pain relevance and then by number of times they were reported in Carotid Stenosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT86184 Negative_regulation of Acsl1 10 0.34 20.45 2.23 100.00
2 INT75869 Gene_expression of Acsl1 24 0.45 27.76 3.66 100.00
3 INT3405 Gene_expression of BCAR1 14 0.71 8.89 4.02 100.00
4 INT55619 Binding of Acsl1 8 0.31 9.91 1.22 100.00
5 INT3404 Binding of BCAR1 10 0.33 7.97 1.33 100.00
6 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 99.96
7 INT67868 Negative_regulation of Gene_expression of Tgfb1 18 0.43 14.27 5.16 99.92
8 INT48202 Gene_expression of Tgfb1 146 0.78 89.93 27.76 99.76
9 INT123466 Binding of T2dm2 21 0.37 34.87 2.91 99.68
10 INT17182 Binding of Cea 25 0.48 14.98 4.16 99.56
11 INT65390 Positive_regulation of Plat 30 0.70 23.31 9.31 99.44
12 INT199315 Binding of Plat 8 0.34 7.02 1.14 99.38
13 INT27207 Gene_expression of Psd 31 0.73 15.44 2.75 97.20
14 INT14902 Negative_regulation of XDH 38 0.55 24.19 2.86 96.24
15 INT671 Positive_regulation of Cea 221 0.69 164.5 47.79 95.00
16 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 94.80
17 INT61378 Positive_regulation of Bcar1 13 0.45 2.84 2.45 94.00
18 INT167182 Binding of Psd 9 0.41 13.08 1.06 92.52
19 INT2137 Localization of Cea 27 0.70 19.22 6.14 92.32
20 INT65260 Positive_regulation of Col7a1 95 0.69 61.73 18.42 92.32
21 INT251228 Phosphorylation of Tgfb1 4 0.15 1.18 0.24 91.52
22 INT187994 Binding of CIMT 20 0.47 12.97 2.04 91.44
23 INT59287 Positive_regulation of Eda 5 0.40 1.25 2.36 90.84
24 INT168600 Binding of Mmp9 14 0.44 12.79 6.92 90.68
25 INT97216 Positive_regulation of Psd 13 0.45 7.04 1.25 90.56
26 INT64685 Positive_regulation of Gzma 2 0.09 0.43 0.09 90.56
27 INT64684 Positive_regulation of RT1-T18 1 0.02 0.32 0.09 90.56
28 INT8684 Positive_regulation of ANGPTL5 45 0.69 36.29 7.47 87.08
29 INT96937 Gene_expression of Mmp9 191 0.75 150.3 56.01 84.68
30 INT78592 Positive_regulation of Atp9b 4 0.49 1.54 0.44 83.92
31 INT342454 Positive_regulation of Rnf130 1 0.49 0.61 0.05 83.92
32 INT111032 Binding of ACOT8 1 0.36 1.51 0.18 82.40
33 INT115384 Positive_regulation of Mmp9 121 0.68 94.74 43.02 81.96
34 INT160914 Positive_regulation of Positive_regulation of Mmp9 7 0.57 4.69 4.52 81.96
35 INT95767 Negative_regulation of Mmp9 72 0.57 49.14 17.1 80.76
36 INT48203 Positive_regulation of Tgfb1 67 0.70 41.31 11.07 79.60
37 INT351326 Gene_expression of pdw 1 0.41 0.23 0.28 78.84
38 INT56447 Positive_regulation of Icam1 64 0.64 64.14 16.16 75.32
39 INT102738 Binding of Atp9b 4 0.36 1.65 0.68 75.04
40 INT342455 Binding of Rnf130 1 0.36 0.73 0.16 75.04
41 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 75.00
42 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 75.00
43 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 75.00
44 INT99550 Regulation of FLNA 51 0.54 27.88 2.58 75.00
45 INT126672 Binding of Bcar1 7 0.20 2.67 0.98 74.80
46 INT272256 Protein_catabolism of Psd 3 0.49 2.66 0.19 68.32
47 INT72182 Gene_expression of Mcpt1 167 0.75 123.7 52.15 65.92
48 INT62543 Gene_expression of Icam1 231 0.78 187.58 52.71 65.92
49 INT180379 Gene_expression of Olr1 31 0.36 36.46 4.84 65.44
50 INT144945 Negative_regulation of Icam1 27 0.50 26.23 7.08 64.92
51 INT93663 Positive_regulation of MMP1 72 0.67 33.38 19.86 63.12
52 INT2532 Negative_regulation of Cebpz 98 0.00 53.06 28.57 56.08
53 INT14916 Binding of RASA1 15 0.37 13.64 1.44 54.08
54 INT146197 Positive_regulation of Rhoa 60 0.68 34.12 12.02 50.72
55 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 50.00
56 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 50.00
57 INT68373 Negative_regulation of FLNA 59 0.57 60.46 9.55 50.00
58 INT113948 Gene_expression of FLNA 32 0.73 36.06 4.81 50.00
59 INT39948 Binding of FLNA 45 0.42 58.05 4.27 50.00
60 INT63880 Positive_regulation of FLNA 29 0.59 13.88 3.97 50.00
61 INT201818 Regulation of CDH2 3 0.09 1.89 0.04 50.00
62 INT96269 Positive_regulation of Mcpt1 71 0.61 52.38 20.4 47.68
63 INT62546 Positive_regulation of Gene_expression of Icam1 60 0.70 59.52 16.9 47.68
64 INT96271 Positive_regulation of Gene_expression of Mcpt1 30 0.53 21.34 11.06 47.68
65 INT207850 Positive_regulation of Regulation of Mcpt1 2 0.20 1.65 1.1 47.68
66 INT56445 Regulation of Icam1 14 0.39 15.4 5.32 47.28
67 INT112967 Regulation of Mcpt1 15 0.54 13.03 8.58 46.84
68 INT217070 Gene_expression of Acsm3 8 0.25 6.27 1.75 43.28
69 INT43900 Gene_expression of RASA1 13 0.58 12 2.03 42.32
70 INT198877 Regulation of Gene_expression of Lrp1 2 0.32 0.62 0.17 40.12
71 INT198885 Gene_expression of Lrp1 33 0.57 10.2 1.91 39.68
72 INT104221 Regulation of Gene_expression of CRP 30 0.45 20.01 4.07 38.88
73 INT161766 Localization of Psd 7 0.75 3.53 0.96 37.12
74 INT134748 Positive_regulation of SV2A 7 0.46 2.89 0.82 35.60
75 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 30.40
76 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 30.40
77 INT1533 Negative_regulation of AGT 105 0.42 46.54 16.92 30.08
78 INT11957 Negative_regulation of LPA 52 0.59 39.09 6.84 25.00
79 INT47893 Positive_regulation of MILR1 2 0.21 0.06 0.15 25.00
80 INT185156 Gene_expression of T2dm2 9 0.45 10.44 0.56 19.64
81 INT48199 Regulation of Tgfb1 17 0.54 9.57 2.74 16.88
82 INT170738 Binding of Icam1 23 0.37 25.49 4.09 9.20
83 INT134811 Gene_expression of ICA1 22 0.44 6.47 2.42 5.68
84 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
85 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
86 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 5.00
87 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02 5.00
88 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
89 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 5.00
90 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
91 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
92 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
93 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
94 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
95 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 5.00
96 INT940 Negative_regulation of Ptgs1 219 0.59 104.34 95.97 5.00
97 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.00
98 INT1080 Negative_regulation of Ache 343 0.59 108.51 72.4 5.00
99 INT171145 Positive_regulation of Fig4 274 0.59 93.55 69.81 5.00
100 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 5.00
101 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 5.00
102 INT6477 Gene_expression of IL1RN 213 0.77 114.69 58.62 5.00
103 INT46637 Gene_expression of CXCL10 172 0.78 121.94 57.74 5.00
104 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
105 INT52611 Negative_regulation of Ptgs2 142 0.59 66.31 52.71 5.00
106 INT40777 Positive_regulation of Akt1 163 0.69 59.41 49.43 5.00
107 INT170646 Negative_regulation of Fig4 213 0.37 81.29 46.92 5.00
108 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 5.00
109 INT81498 Positive_regulation of Gene_expression of CCL2 107 0.70 53.89 45.22 5.00
110 INT47939 Gene_expression of Selp 171 0.76 87.54 39.03 5.00
111 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 5.00
112 INT104392 Gene_expression of Cxcl10 113 0.75 106.86 34.12 5.00
113 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 5.00
114 INT65698 Localization of CCL2 118 0.81 77.54 32.69 5.00
115 INT62830 Gene_expression of VCAM1 149 0.78 125.23 32.4 5.00
116 INT121663 Gene_expression of CXCR3 76 0.77 50.96 30.62 5.00
117 INT72923 Positive_regulation of MCRS1 72 0.50 99.19 30.36 5.00
118 INT660 Negative_regulation of REN 194 0.59 82.06 29.46 5.00
119 INT9199 Positive_regulation of CEBPZ 111 0.67 30.99 28.45 5.00
120 INT177581 Regulation of Fig4 113 0.41 39.26 27.75 5.00
121 INT116861 Gene_expression of Apoe 182 0.78 100.41 27.26 5.00
122 INT100861 Binding of CRP 179 0.48 175.2 26.45 5.00
123 INT17625 Localization of GCG 210 0.80 55.69 24.97 5.00
124 INT58192 Positive_regulation of MRI1 86 0.61 53.81 24.68 5.00
125 INT100423 Gene_expression of Bax 141 0.75 98.43 24.48 5.00
126 INT94335 Positive_regulation of CXCL10 71 0.58 50.69 23 5.00
127 INT8640 Positive_regulation of HSD11B1 332 0.67 377.84 22.36 5.00
128 INT23257 Regulation of CRP 127 0.62 100.05 21.87 5.00
129 INT16396 Negative_regulation of CEBPZ 76 0.48 30.03 21.6 5.00
130 INT76924 Positive_regulation of Slc17a5 71 0.70 41.21 19.31 5.00
131 INT192409 Positive_regulation of Gene_expression of IFN1@ 102 0.67 64.66 18.8 5.00
132 INT80755 Gene_expression of CD40 88 0.75 53.68 17.86 5.00
133 INT132997 Localization of Mmp9 59 0.80 45.9 17.61 5.00
134 INT84464 Gene_expression of DPP4 101 0.78 56.15 17.53 5.00
135 INT3206 Positive_regulation of Got1 39 0.69 19.36 17.02 5.00
136 INT1767 Positive_regulation of PROC 83 0.67 54.14 17 5.00
137 INT65211 Binding of Prkcg 38 0.48 14.75 16.92 5.00
138 INT110767 Localization of Mcpt1 43 0.68 24.3 16.74 5.00
139 INT10834 Binding of IL8 65 0.48 41.66 16.53 5.00
140 INT14152 Gene_expression of Slc17a5 46 0.61 20.01 15.9 5.00
141 INT3793 Regulation of CEBPZ 59 0.61 20.91 15.83 5.00
142 INT106745 Localization of CRP 65 0.81 66.44 15.21 5.00
143 INT75540 Positive_regulation of TH1L 62 0.67 43.45 15.02 5.00
144 INT180497 Binding of MRI1 45 0.42 28.35 14.77 5.00
145 INT11340 Positive_regulation of SLC17A5 120 0.67 113.52 14.5 5.00
146 INT184890 Regulation of MCRS1 35 0.22 44.35 13.78 5.00
147 INT15684 Positive_regulation of Serpine1 65 0.70 43.51 13.67 5.00
148 INT22213 Localization of Gpt 52 0.78 34.05 12.94 5.00
149 INT20102 Gene_expression of Serpine1 102 0.78 65.99 12.61 5.00
150 INT92686 Gene_expression of Ctgf 51 0.77 34.4 11.93 5.00
151 INT73959 Positive_regulation of NOSTRIN 49 0.61 31.1 11.27 5.00
152 INT94438 Gene_expression of OLR1 86 0.78 80.38 11.03 5.00
153 INT62895 Gene_expression of NOSTRIN 51 0.75 28.8 10.68 5.00
154 INT170333 Binding of IFN1@ 68 0.47 49.01 9.72 5.00
155 INT132036 Negative_regulation of DPP4 126 0.59 63.24 9.51 5.00
156 INT102110 Positive_regulation of Gene_expression of Bax 42 0.67 35.77 9.51 5.00
157 INT26492 Negative_regulation of Localization of GCG 73 0.58 22.2 9.48 5.00
158 INT20664 Binding of ACE 60 0.48 35.27 9.16 5.00
159 INT2139 Negative_regulation of Cea 55 0.43 43.59 9.14 5.00
160 INT52442 Binding of Ptgs1 16 0.35 9.05 8.78 5.00
161 INT22383 Binding of IL2 59 0.48 39.06 8.56 5.00
162 INT8637 Negative_regulation of Dbp 112 0.50 33.28 8.4 5.00
163 INT162393 Gene_expression of SMUG1 58 0.75 38.78 7.7 5.00
164 INT153300 Negative_regulation of Gene_expression of CRP 48 0.58 39.97 7.58 5.00
165 INT134967 Gene_expression of Ecm1 66 0.29 38.4 7.16 5.00
166 INT93003 Binding of CD40 28 0.47 20.25 7.13 5.00
167 INT32709 Negative_regulation of Hbb 30 0.54 18.27 6.97 5.00
168 INT61120 Positive_regulation of Gene_expression of Tgfb1 34 0.70 21.15 6.93 5.00
169 INT36053 Positive_regulation of Positive_regulation of IL1B 22 0.70 11.41 6.84 5.00
170 INT16395 Gene_expression of CEBPZ 30 0.57 11.02 6.66 5.00
171 INT171749 Positive_regulation of Gene_expression of CXCR3 18 0.58 11.03 6.51 5.00
172 INT166707 Protein_catabolism of Col7a1 24 0.74 20.47 6.39 5.00
173 INT17262 Negative_regulation of Plat 17 0.59 15.14 6.36 5.00
174 INT65265 Positive_regulation of Gene_expression of Col7a1 48 0.69 23.81 6.16 5.00
175 INT179810 Protein_catabolism of Ecm1 30 0.11 18.28 5.75 5.00
176 INT120550 Negative_regulation of Rock1 27 0.42 18.38 5.66 5.00
177 INT21103 Gene_expression of Dbp 48 0.61 22.6 5.59 5.00
178 INT48201 Localization of Tgfb1 27 0.59 13.65 5.54 5.00
179 INT144946 Localization of Icam1 21 0.75 21.84 5.33 5.00
180 INT48200 Transcription of Tgfb1 13 0.69 3.85 5.24 5.00
181 INT111594 Positive_regulation of Gene_expression of NOSTRIN 20 0.32 8.69 5 5.00
182 INT16214 Localization of F13A1 36 0.74 21.8 4.87 5.00
183 INT104668 Negative_regulation of Plat 27 0.49 17.18 4.83 5.00
184 INT92682 Positive_regulation of Gene_expression of Ctgf 17 0.69 12.16 4.51 5.00
185 INT29231 Regulation of Dbp 44 0.53 10.08 4.47 5.00
186 INT134968 Localization of Ecm1 20 0.32 27.27 4.31 5.00
187 INT69681 Negative_regulation of Tgfb1 42 0.51 22.28 4 5.00
188 INT4012 Negative_regulation of Psd 23 0.52 14.12 3.81 5.00
189 INT120072 Gene_expression of Smad7 38 0.74 20.87 3.69 5.00
190 INT92678 Positive_regulation of Ecm1 30 0.09 28.41 3.68 5.00
191 INT16263 Regulation of Serpine1 13 0.45 5.24 3.6 5.00
192 INT137180 Binding of CXCR3 10 0.41 4.24 3.53 5.00
193 INT92681 Positive_regulation of Ctgf 13 0.69 9.78 3.47 5.00
194 INT38303 Binding of Gpt 21 0.47 15.84 3.43 5.00
195 INT113604 Negative_regulation of Gene_expression of Ctgf 19 0.58 9.37 3.43 5.00
196 INT237054 Negative_regulation of Gene_expression of Cxcl10 11 0.56 10.26 3.4 5.00
197 INT207449 Negative_regulation of OLR1 23 0.42 17.17 3.37 5.00
198 INT182233 Gene_expression of CCR4 14 0.43 6.55 3.31 5.00
199 INT70958 Binding of NOS3 19 0.37 11.84 3.29 5.00
200 INT146194 Negative_regulation of Rhoa 21 0.42 11.05 3.22 5.00
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