D:Cartilage Diseases

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pChart

Disease Term
Synonyms CARTILAGE DISEASE, Disease Cartilage, Diseases Cartilage
Documents 14
Hot Single Events 4
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Cartilage Diseases. They are ordered first by their relevance to Cartilage Diseases and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT287894 VEGFA Positive_regulation of Localization of BMP4 1 0.04 2.49 0.2 5.00
2 INT287890 THEMIS Regulation of Gene_expression of EPHB2 1 0.00 0.87 0.14 5.00
3 INT287883 FOS Regulation of Gene_expression of EPHB2 1 0.01 0.87 0.14 5.00
4 INT287884 WNT5A Positive_regulation of THEMIS 1 0.00 0.08 0.13 5.00
5 INT287878 Binding of CREB1 and CREBBP 2 0.01 0.16 0.12 5.00
6 INT287881 THEMIS Positive_regulation of PRKCA 1 0.00 0.07 0.12 5.00
7 INT287893 VEGFA Positive_regulation of Localization of WISP1 1 0.03 1.23 0.1 5.00
8 INT287887 WNT1 Positive_regulation of Localization of BMP4 1 0.04 1.13 0.1 5.00
9 INT287886 Negative_regulation of THEMIS Negative_regulation of PRKCA 1 0.00 1.19 0.08 5.00
10 INT287879 Binding of WNT5A and FZD5 1 0.06 1.16 0.08 5.00
11 INT287880 Binding of CREB1 and EP300 1 0.01 0 0.08 5.00
12 INT287877 WNT1 Positive_regulation of Localization of WISP1 1 0.03 0.56 0.05 5.00
13 INT287889 WNT1 Positive_regulation of KRT20 1 0.00 0.56 0.05 5.00
14 INT287892 PRDX2 Positive_regulation of HNF4A 1 0.00 0.52 0 5.00
15 INT287875 EP300 Negative_regulation of HDAC9 1 0.04 0.51 0 5.00
16 INT287882 Binding of CREBBP and HNF4A 1 0.01 0.85 0 5.00
17 INT287885 Binding of DVL1 and AXIN1 1 0.02 0 0 5.00
18 INT287891 Binding of CDH1 and KRT20 1 0.00 0.5 0 5.00
19 INT287874 Binding of TCF4 and TP53 1 0.02 0.54 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Cartilage Diseases. They are ordered first by their pain relevance and then by number of times they were reported in Cartilage Diseases. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT16130 Binding of IGF1 67 0.48 27.43 2.95 96.24
2 INT11659 Gene_expression of COL2A1 164 0.78 78.49 22.58 95.04
3 INT158124 Gene_expression of COL5A2 136 0.69 72.3 12.44 86.92
4 INT103094 Binding of PPARA 308 0.47 177.26 34.75 81.84
5 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 75.12
6 INT322094 Positive_regulation of Gene_expression of RAPH1 1 0.07 0.32 0 68.92
7 INT193199 Gene_expression of RAPH1 6 0.60 4.55 0.36 67.64
8 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 67.44
9 INT173159 Localization of PPARA 96 0.74 64.55 10.26 50.88
10 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 5.00
11 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
12 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 5.00
13 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
14 INT52712 Negative_regulation of PRKCA 64 0.57 23.11 28.43 5.00
15 INT81210 Positive_regulation of PRKG1 71 0.70 26.83 19.89 5.00
16 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9 5.00
17 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 5.00
18 INT124371 Negative_regulation of Gsk3b 170 0.55 87.92 15.51 5.00
19 INT124372 Gene_expression of Gsk3b 164 0.75 95.64 14.35 5.00
20 INT114274 Gene_expression of Rxra 67 0.70 36.77 12.5 5.00
21 INT170601 Positive_regulation of Gene_expression of GOPC 122 0.43 42.79 11.68 5.00
22 INT57057 Gene_expression of APC 131 0.78 122.24 8.7 5.00
23 INT89677 Gene_expression of PRKG1 38 0.78 13.98 8.56 5.00
24 INT111607 Gene_expression of CDH1 103 0.75 90.45 7.77 5.00
25 INT16631 Negative_regulation of APC 46 0.57 30.53 7.11 5.00
26 INT125143 Gene_expression of EPHB2 40 0.71 13.27 6.97 5.00
27 INT192225 Gene_expression of HDAC9 35 0.58 32.82 6.36 5.00
28 INT3819 Positive_regulation of Apc 36 0.69 27.03 6.02 5.00
29 INT116055 Phosphorylation of PRKG1 33 0.80 2.22 5.58 5.00
30 INT57064 Positive_regulation of APC 72 0.66 48.5 5.08 5.00
31 INT181186 Binding of Rxra 78 0.35 14.93 4.87 5.00
32 INT20552 Negative_regulation of Gene_expression of COL2A1 29 0.56 11.92 4.81 5.00
33 INT135374 Binding of Gsk3b 46 0.48 24.36 4.75 5.00
34 INT75523 Regulation of MAPK8 21 0.33 11.18 4.28 5.00
35 INT167284 Phosphorylation of Gsk3b 88 0.82 36.03 4.21 5.00
36 INT12915 Gene_expression of MGP 18 0.75 7.53 4.15 5.00
37 INT89678 Positive_regulation of Gene_expression of PRKG1 15 0.70 5.99 3.84 5.00
38 INT63121 Binding of APC 29 0.41 23.02 3.8 5.00
39 INT135373 Regulation of Gsk3b 35 0.62 18.11 3.53 5.00
40 INT170606 Regulation of Gene_expression of GOPC 31 0.37 6.08 3.31 5.00
41 INT68445 Gene_expression of ENPP1 10 0.70 10.8 3.3 5.00
42 INT172001 Gene_expression of ANKH 2 0.38 11.92 3.12 5.00
43 INT38673 Negative_regulation of KRT20 38 0.42 22.49 2.77 5.00
44 INT60750 Gene_expression of HNF4A 12 0.65 8.29 2.68 5.00
45 INT20551 Negative_regulation of COL2A1 31 0.55 21.98 2.66 5.00
46 INT171511 Gene_expression of EP300 14 0.53 4.17 2.29 5.00
47 INT109327 Negative_regulation of KIT 42 0.57 43.2 2.15 5.00
48 INT161382 Localization of KRT20 25 0.61 12.97 2.13 5.00
49 INT8462 Binding of MUC7 11 0.36 1.79 2.11 5.00
50 INT141833 Gene_expression of WNT1 14 0.75 10.57 2.1 5.00
51 INT171514 Binding of EP300 13 0.32 4.32 2.01 5.00
52 INT125080 Positive_regulation of Positive_regulation of TP53 21 0.58 16.16 1.98 5.00
53 INT316778 Positive_regulation of Gene_expression of ENPP1 1 0.62 7.2 1.97 5.00
54 INT199724 Positive_regulation of Gene_expression of Rxra 11 0.45 6.22 1.88 5.00
55 INT316776 Positive_regulation of Gene_expression of ANKH 1 0.31 5.29 1.49 5.00
56 INT272884 Gene_expression of Hdac2 19 0.43 14.55 1.48 5.00
57 INT101990 Negative_regulation of Positive_regulation of TP53 5 0.33 3.69 1.42 5.00
58 INT224501 Positive_regulation of Gene_expression of EPHB2 9 0.49 4.29 1.39 5.00
59 INT139237 Negative_regulation of Gene_expression of CDH1 23 0.57 24.31 1.28 5.00
60 INT172630 Binding of HNF4A 16 0.05 7.78 1.22 5.00
61 INT134663 Gene_expression of SOX9 40 0.75 9.07 1.2 5.00
62 INT150074 Gene_expression of WNT5A 8 0.75 6.3 1.17 5.00
63 INT123877 Negative_regulation of ABL1 40 0.57 27.94 1.17 5.00
64 INT167283 Negative_regulation of Phosphorylation of Gsk3b 12 0.59 7.94 1.16 5.00
65 INT118258 Positive_regulation of ENPP1 3 0.62 4.26 1.16 5.00
66 INT111605 Positive_regulation of CDH1 12 0.50 7.95 1.15 5.00
67 INT11658 Regulation of Gene_expression of COL2A1 9 0.62 3.09 1.11 5.00
68 INT172616 Regulation of HNF4A 9 0.06 4.25 1.02 5.00
69 INT190361 Protein_catabolism of PPARA 12 0.97 3.01 0.87 5.00
70 INT287954 Gene_expression of DVL1 8 0.24 2.48 0.83 5.00
71 INT167285 Positive_regulation of Phosphorylation of Gsk3b 17 0.50 5.92 0.82 5.00
72 INT114956 Gene_expression of CREBBP 5 0.31 1.56 0.75 5.00
73 INT40369 Gene_expression of LRP5 8 0.55 5.63 0.74 5.00
74 INT272883 Positive_regulation of Gene_expression of Hdac2 5 0.30 4.64 0.7 5.00
75 INT47038 Gene_expression of SFRP1 14 0.67 9.6 0.63 5.00
76 INT184222 Negative_regulation of SOX9 7 0.41 2.68 0.58 5.00
77 INT164196 Binding of LRP1 5 0.47 2.59 0.53 5.00
78 INT316777 Binding of LRRC26 1 0.06 2.09 0.51 5.00
79 INT275642 Negative_regulation of HNF4A 4 0.05 2.08 0.44 5.00
80 INT109191 Positive_regulation of ANKH 1 0.50 1.36 0.44 5.00
81 INT204012 Regulation of Negative_regulation of Gsk3b 4 0.42 4.51 0.39 5.00
82 INT234421 Binding of TCF4 13 0.18 2.3 0.37 5.00
83 INT163489 Binding of CDH1 13 0.19 8.63 0.35 5.00
84 INT316779 Positive_regulation of Gene_expression of MGP 1 0.17 1.52 0.35 5.00
85 INT127871 Regulation of Gene_expression of CDH1 4 0.44 2.34 0.34 5.00
86 INT106253 Positive_regulation of HNF4A 14 0.29 3.88 0.34 5.00
87 INT287929 Negative_regulation of THEMIS 1 0.01 2.44 0.3 5.00
88 INT287931 Positive_regulation of Gene_expression of DVL1 2 0.09 0.08 0.29 5.00
89 INT183208 Transcription of HNF4A 7 0.11 3.15 0.28 5.00
90 INT173655 Binding of LRP5 10 0.39 3.06 0.22 5.00
91 INT197429 Gene_expression of TCF4 6 0.33 3.8 0.18 5.00
92 INT57065 Negative_regulation of Positive_regulation of APC 3 0.22 2.43 0.17 5.00
93 INT66933 Binding of AXIN1 6 0.32 1.8 0.16 5.00
94 INT152666 Negative_regulation of CREBBP 2 0.06 0.52 0.14 5.00
95 INT287917 Phosphorylation of HNF4A 1 0.08 0.07 0.13 5.00
96 INT287922 Phosphorylation of DVL1 4 0.20 1.21 0.12 5.00
97 INT287919 Negative_regulation of SGPP1 2 0.07 0.93 0.12 5.00
98 INT287914 Binding of LRP6 2 0.15 0.28 0.11 5.00
99 INT287912 Localization of BMP4 1 0.18 1.13 0.1 5.00
100 INT287943 Negative_regulation of Transcription of TCF4 1 0.15 0 0.09 5.00
101 INT234413 Transcription of TCF4 3 0.34 1 0.09 5.00
102 INT287918 Negative_regulation of Binding of TCF4 1 0.15 0 0.09 5.00
103 INT184220 Negative_regulation of Gene_expression of SOX9 4 0.36 0.58 0.09 5.00
104 INT171528 Binding of CREBBP 3 0.07 0.47 0.08 5.00
105 INT287927 Positive_regulation of THEMIS 1 0.01 3.23 0.07 5.00
106 INT287926 Binding of THEMIS 1 0.00 1.59 0.06 5.00
107 INT287947 Binding of DVL1 3 0.10 0.95 0.06 5.00
108 INT173650 Localization of WISP1 2 0.15 0.65 0.05 5.00
109 INT217905 Phosphorylation of CSNK1A1 3 0.54 2.14 0.05 5.00
110 INT272249 Negative_regulation of Negative_regulation of COL2A1 1 0.06 0 0.05 5.00
111 INT287945 Regulation of THEMIS 1 0.00 1.7 0.05 5.00
112 INT287913 Positive_regulation of Gene_expression of SFRP1 2 0.25 2.12 0.05 5.00
113 INT287925 Regulation of Binding of HNF4A 1 0.06 1.1 0.05 5.00
114 INT287946 Positive_regulation of Gene_expression of FZD5 2 0.20 1.69 0.04 5.00
115 INT287956 Regulation of WNT1 2 0.26 2.38 0.04 5.00
116 INT287924 Negative_regulation of WIF1 1 0.13 1.62 0.04 5.00
117 INT287936 Regulation of Gene_expression of WNT1 1 0.20 1.06 0.04 5.00
118 INT287920 Positive_regulation of DVL1 3 0.49 1.29 0.03 5.00
119 INT287941 Gene_expression of FZD5 2 0.23 2.94 0.03 5.00
120 INT287933 Negative_regulation of Binding of CDH1 1 0.03 0.65 0.03 5.00
121 INT287932 Negative_regulation of Binding of AXIN1 1 0.12 0 0 5.00
122 INT287949 Positive_regulation of Positive_regulation of CDH1 3 0.06 1.4 0 5.00
123 INT287950 Negative_regulation of Positive_regulation of CDH1 1 0.03 0.56 0 5.00
124 INT287939 Positive_regulation of Negative_regulation of TCF4 1 0.17 0.52 0 5.00
125 INT287916 Negative_regulation of TCF4 1 0.20 0.52 0 5.00
126 INT287952 Positive_regulation of Gene_expression of TCF4 1 0.17 0.69 0 5.00
127 INT287937 Positive_regulation of Positive_regulation of DVL1 2 0.12 0.52 0 5.00
128 INT206742 Negative_regulation of PRDX2 5 0.04 5.04 0 5.00
129 INT195681 Positive_regulation of Negative_regulation of APC 5 0.47 3.9 0 5.00
130 INT287915 Positive_regulation of Positive_regulation of HNF4A 1 0.06 0.37 0 5.00
131 INT287935 Positive_regulation of Binding of AXIN1 1 0.14 0 0 5.00
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