D:Castlemans Disease

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Disease Term
Synonyms Angiofollicular Lymph Node Hyperplasia, Angiofollicular Lymphoid Hyperplasia, Angiofollicular Lymphoid Hyperplasias, ANGIOLYMPHOID HYPERPLASIA, Angiomatous Lymphoid Hamartoma, Benign Angiofollicular Hyperplasia, BENIGN LYMPH NODE GROWTH, Benign Lymph Node Tumor, Benign Lymph Node Tumors, BENIGN LYMPH NODE TUMOUR, BENIGN LYMPH NODE TUMOURS
Documents 39
Hot Single Events 18
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Castlemans Disease. They are ordered first by their relevance to Castlemans Disease and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT204246 ETFA Regulation of CD68 1 0.37 1.05 0.04 94.16
2 INT204247 S100B Regulation of CD68 1 0.03 1.05 0.04 94.16
3 INT115367 Binding of IL6 and IL6R 12 0.07 8.16 2.36 5.00
4 INT218309 Binding of CRP and IL6 3 0.23 4.78 1.36 5.00
5 INT206074 Binding of IL6 and IL6ST 7 0.32 3.79 1.01 5.00
6 INT254360 Binding of EPAS1 and HIF1A 3 0.39 3.36 0.46 5.00
7 INT276301 Binding of CCL21 and CXCL13 1 0.04 1.85 0.18 5.00
8 INT276304 PRDM1 Regulation of TSC1 1 0.01 1.29 0.09 5.00
9 INT276391 Prdm1 Regulation of TSC1 1 0.00 1.29 0.09 5.00
10 INT276375 Binding of Prdm1 and MIR9-1 1 0.12 1.12 0.08 5.00
11 INT276383 Binding of PRDM1 and Mirlet7a-1 1 0.39 1.12 0.08 5.00
12 INT276334 Binding of Prdm1 and Mirlet7a-1 1 0.12 1.13 0.08 5.00
13 INT276384 Binding of Mirlet7a-1 and MIR9-1 1 0.39 1.12 0.08 5.00
14 INT276337 Timp1 Positive_regulation of Il10 1 0.01 0.76 0.05 5.00
15 INT276386 Gtf3a Regulation of PTPN6 1 0.00 0.86 0.04 5.00
16 INT276381 Timp1 Positive_regulation of CD44 1 0.07 0.72 0.04 5.00
17 INT276392 Timp1 Regulation of PTPN6 1 0.02 0.87 0.04 5.00
18 INT276376 Gtf3a Regulation of CD44 1 0.00 0.86 0.04 5.00
19 INT276385 Timp1 Regulation of CD44 1 0.04 0.87 0.04 5.00
20 INT276377 Binding of Lgals1 and KRT20 1 0.00 1.11 0.03 5.00
21 INT276388 Il22 Positive_regulation of STAT3 1 0.03 1.3 0.03 5.00
22 INT276305 Binding of LGALS1 and KRT20 1 0.01 1.11 0.03 5.00
23 INT276389 Binding of Trp53 and KRT20 1 0.01 0.97 0.03 5.00
24 INT276382 Binding of CIB1 and Skp2 1 0.01 0.57 0 5.00
25 INT276300 TAT Regulation of Gene_expression of VEGFA 1 0.14 1.58 0 5.00
26 INT276390 Positive_regulation of CD40 Positive_regulation of Gene_expression of Pdcd1 1 0.01 1.06 0 5.00
27 INT276378 CD40 Positive_regulation of Gene_expression of Pdcd1 1 0.01 1.06 0 5.00
28 INT276387 ALK Positive_regulation of Gene_expression of Il22ra1 1 0.00 1.55 0 5.00
29 INT276380 Binding of PIM1 and Trp53 1 0.01 0.66 0 5.00
30 INT276379 Binding of SKP2 and Cdkn1b 1 0.02 0.57 0 5.00
31 INT276303 Negative_regulation of AKT1 Negative_regulation of CCND1 1 0.01 0.58 0 5.00
32 INT276336 Skp2 Regulation of Cdkn1b 1 0.00 0.57 0 5.00
33 INT276374 Skp2 Regulation of Protein_catabolism of CIB1 1 0.00 0.58 0 5.00
34 INT276335 Binding of Cdkn1b and Skp2 1 0.00 0.57 0 5.00
35 INT276333 Binding of Il10rb and Il22ra1 1 0.00 1.25 0 5.00
36 INT276302 Binding of SKP2 and CIB1 1 0.03 0.57 0 5.00
37 INT276393 Skp2 Regulation of CIB1 1 0.00 0.57 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Castlemans Disease. They are ordered first by their pain relevance and then by number of times they were reported in Castlemans Disease. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 99.20
2 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 99.20
3 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 98.82
4 INT229679 Localization of Plec 4 0.65 1.64 0.35 95.00
5 INT229678 Regulation of Localization of Plec 1 0.25 0.78 0.07 95.00
6 INT10706 Regulation of Il6 150 0.62 93.23 62.34 94.04
7 INT9210 Regulation of IL6 166 0.62 125.61 49.95 92.56
8 INT10612 Localization of NLRP3 13 0.78 8.91 2.27 92.48
9 INT257406 Localization of TNFRSF1A 3 0.46 2.6 0.55 92.48
10 INT257407 Localization of MVK 1 0.22 1.78 0.18 92.48
11 INT80005 Gene_expression of MVK 4 0.09 1.79 1.34 92.04
12 INT15132 Gene_expression of TNFRSF1A 33 0.75 20.09 5.93 91.84
13 INT23174 Gene_expression of NLRP3 51 0.72 35.49 6.47 91.28
14 INT16364 Gene_expression of HLA-DRA 234 0.78 118.81 45.01 89.36
15 INT122988 Gene_expression of CLU 28 0.75 24.07 1.21 88.72
16 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 87.44
17 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 87.20
18 INT200851 Binding of Plec 8 0.44 4.77 0.46 81.52
19 INT183817 Localization of BEST1 6 0.26 5.22 0.16 76.80
20 INT9234 Negative_regulation of Gene_expression of IL6 171 0.59 101.61 53.15 72.36
21 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 69.84
22 INT83896 Gene_expression of CD1A 19 0.68 15.58 2.1 69.84
23 INT204256 Gene_expression of HCLS1 1 0.03 5.24 0.07 66.40
24 INT211097 Negative_regulation of Binding of Pnp 1 0.08 1.27 0.08 64.00
25 INT40322 Binding of Pnp 12 0.38 11.13 1.78 62.88
26 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 56.08
27 INT2120 Gene_expression of CD79A 159 0.78 111.69 17.16 56.08
28 INT19491 Gene_expression of CD19 44 0.75 28.8 3.47 56.08
29 INT153260 Gene_expression of CD22 19 0.70 8.35 0.39 56.08
30 INT173939 Negative_regulation of IL6R 9 0.11 5.92 1.83 54.48
31 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 54.00
32 INT174816 Binding of IL6R 14 0.09 11.26 3.63 52.40
33 INT68228 Positive_regulation of TNFRSF8 5 0.56 6.26 0.84 51.72
34 INT107118 Positive_regulation of ALK 4 0.49 3.64 0.52 51.72
35 INT846 Positive_regulation of B2M 42 0.70 29.78 8.06 49.76
36 INT39417 Gene_expression of Fcer2a 65 0.76 32.1 7.37 46.56
37 INT167381 Localization of DES 4 0.73 4.15 0.77 45.36
38 INT204254 Localization of KIT 8 0.73 6.78 0.61 45.36
39 INT134223 Localization of CD99 4 0.73 4.42 0.16 45.36
40 INT204255 Localization of MYOG 1 0.18 1.82 0.03 45.36
41 INT45818 Gene_expression of C4A 35 0.75 26.4 3.52 44.80
42 INT204253 Binding of TTF1 1 0.16 1.71 0 43.92
43 INT205269 Positive_regulation of Plec 8 0.43 1.78 1.55 43.12
44 INT12325 Gene_expression of Plec 47 0.72 11.92 13.35 36.96
45 INT66852 Gene_expression of Fcer2 15 0.14 9.74 1.27 22.72
46 INT229677 Binding of Pan3 1 0.01 1.44 0.21 21.00
47 INT70954 Negative_regulation of Cd3e 11 0.41 4.22 1.31 20.96
48 INT28694 Negative_regulation of CD2 2 0.37 1.21 0.45 20.32
49 INT50230 Positive_regulation of Localization of IL6 105 0.70 69.21 29.52 16.00
50 INT12082 Localization of IL6 365 0.81 241.78 105.78 15.56
51 INT183816 Gene_expression of HIVEP2 3 0.08 2.63 0.9 10.56
52 INT75501 Gene_expression of CCND1 90 0.76 60.86 5.93 8.40
53 INT75498 Positive_regulation of Gene_expression of CCND1 21 0.68 19.4 0.51 8.40
54 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
55 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
56 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
57 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 5.00
58 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
59 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
60 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
61 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
62 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
63 INT5056 Gene_expression of IFNG 216 0.78 137.52 74.57 5.00
64 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
65 INT11807 Gene_expression of Il2 266 0.78 112 64.97 5.00
66 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
67 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
68 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
69 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53 5.00
70 INT117598 Regulation of ACR 118 0.26 41.25 48.01 5.00
71 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
72 INT100939 Gene_expression of Il13 176 0.73 125.1 43.38 5.00
73 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 5.00
74 INT163134 Gene_expression of ACR 78 0.65 30.39 38.48 5.00
75 INT168410 Gene_expression of Cxcr3 81 0.75 84.03 37.01 5.00
76 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 5.00
77 INT12892 Negative_regulation of TIMP1 136 0.58 83.13 36.54 5.00
78 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 5.00
79 INT666 Gene_expression of Jun 124 0.78 54.61 33.67 5.00
80 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7 5.00
81 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 5.00
82 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 5.00
83 INT6660 Positive_regulation of Jun 148 0.69 67.58 29.73 5.00
84 INT86437 Binding of IL6 154 0.48 121.22 29.3 5.00
85 INT17331 Positive_regulation of JUN 132 0.69 60.4 27.03 5.00
86 INT59449 Negative_regulation of Timp1 76 0.42 54.86 26.99 5.00
87 INT69157 Gene_expression of IL5 127 0.77 102.58 26.81 5.00
88 INT100861 Binding of CRP 179 0.48 175.2 26.45 5.00
89 INT20462 Binding of ESR1 210 0.44 102.7 26.34 5.00
90 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 5.00
91 INT4877 Gene_expression of MME 184 0.78 122.82 24.78 5.00
92 INT11804 Positive_regulation of Gene_expression of Il2 70 0.70 33 21.63 5.00
93 INT160564 Gene_expression of Il22 64 0.55 59.29 20.9 5.00
94 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44 5.00
95 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 5.00
96 INT21532 Negative_regulation of Gene_expression of Il2 47 0.59 20.43 16.96 5.00
97 INT65659 Positive_regulation of STAT3 132 0.70 69.56 15.95 5.00
98 INT92354 Localization of ESR1 77 0.75 33.04 15.51 5.00
99 INT81627 Gene_expression of Fas 120 0.78 115.51 15.36 5.00
100 INT106745 Localization of CRP 65 0.81 66.44 15.21 5.00
101 INT10709 Negative_regulation of CD4 106 0.59 95.6 14.89 5.00
102 INT109535 Gene_expression of Vegfa 116 0.75 84.61 14.89 5.00
103 INT105387 Gene_expression of HIF1A 116 0.77 98.62 14.66 5.00
104 INT60197 Gene_expression of JUN 90 0.78 42.32 14.61 5.00
105 INT11340 Positive_regulation of SLC17A5 120 0.67 113.52 14.5 5.00
106 INT124372 Gene_expression of Gsk3b 164 0.75 95.64 14.35 5.00
107 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54 5.00
108 INT12084 Regulation of Localization of IL6 36 0.61 20.32 12.34 5.00
109 INT148207 Gene_expression of CTLA4 53 0.77 29.13 12.07 5.00
110 INT36287 Binding of CD4 96 0.47 58.93 11.88 5.00
111 INT69029 Gene_expression of PTPRC 127 0.75 74.26 11.57 5.00
112 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 5.00
113 INT94438 Gene_expression of OLR1 86 0.78 80.38 11.03 5.00
114 INT108479 Positive_regulation of CCL21 18 0.67 19.93 10.76 5.00
115 INT94454 Gene_expression of CD68 73 0.72 63.94 10.43 5.00
116 INT10019 Binding of CD8A 57 0.36 31.49 10.08 5.00
117 INT1118 Gene_expression of C6orf25 73 0.77 47.24 9.1 5.00
118 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 5.00
119 INT119831 Gene_expression of PTEN 55 0.75 40.37 8.57 5.00
120 INT169015 Gene_expression of FOXP3 50 0.60 33.18 8.4 5.00
121 INT36798 Gene_expression of Mki67 178 0.77 132 8.24 5.00
122 INT80220 Positive_regulation of Bcl2 71 0.58 57.73 7.86 5.00
123 INT276358 Gene_expression of MIR150 42 0.74 38.44 7.82 5.00
124 INT39406 Positive_regulation of OLR1 45 0.70 37.8 7.72 5.00
125 INT46221 Positive_regulation of Gene_expression of IgG 46 0.53 33.66 7.7 5.00
126 INT182320 Binding of MTX1 14 0.18 8.5 7.65 5.00
127 INT74520 Positive_regulation of CD68 30 0.61 31.68 7.59 5.00
128 INT26462 Gene_expression of DNAH8 44 0.78 19.36 7.31 5.00
129 INT93003 Binding of CD40 28 0.47 20.25 7.13 5.00
130 INT68653 Negative_regulation of JUN 34 0.58 14.27 6.56 5.00
131 INT173967 Gene_expression of Mri1 26 0.43 16.67 6.45 5.00
132 INT38672 Binding of KRT20 69 0.39 48.01 6.31 5.00
133 INT93359 Positive_regulation of Trp53 90 0.70 69.77 6.24 5.00
134 INT236839 Positive_regulation of CXCL13 14 0.44 19.27 5.81 5.00
135 INT77146 Binding of IL4 23 0.36 13.69 5.39 5.00
136 INT76313 Gene_expression of CD38 30 0.64 20.74 5.27 5.00
137 INT3165 Gene_expression of LYZ 25 0.65 16.72 5.16 5.00
138 INT28084 Positive_regulation of VIM 49 0.67 35.12 5.15 5.00
139 INT34358 Binding of MME 13 0.37 7.25 5.14 5.00
140 INT205272 Positive_regulation of Gene_expression of Plec 11 0.43 1.5 4.49 5.00
141 INT57338 Gene_expression of ITGAX 31 0.75 24.62 4.39 5.00
142 INT103155 Gene_expression of KDR 78 0.66 50.53 4.38 5.00
143 INT4988 Gene_expression of KRT1 64 0.77 43.4 4.12 5.00
144 INT91371 Negative_regulation of STAT3 34 0.59 25 4.08 5.00
145 INT92653 Gene_expression of IL12B 21 0.75 17.28 3.89 5.00
146 INT68269 Gene_expression of CD99 49 0.77 47.38 3.86 5.00
147 INT62784 Gene_expression of NT5E 46 0.65 15.95 3.72 5.00
148 INT14717 Gene_expression of TAT 20 0.75 10.67 3.66 5.00
149 INT149332 Gene_expression of CD163 19 0.75 13.63 3.65 5.00
150 INT90406 Gene_expression of IL6R 27 0.38 15.74 3.64 5.00
151 INT135373 Regulation of Gsk3b 35 0.62 18.11 3.53 5.00
152 INT15930 Positive_regulation of Ptprs 8 0.67 7.02 3.48 5.00
153 INT78284 Positive_regulation of PTPRC 40 0.49 27.17 3.45 5.00
154 INT28359 Gene_expression of Pdcd1 39 0.57 34.09 3.4 5.00
155 INT79270 Gene_expression of MKI67 113 0.77 63.52 3.38 5.00
156 INT93913 Positive_regulation of CD40 21 0.58 23.47 3.1 5.00
157 INT24873 Binding of KLF1 12 0.07 6.73 3.1 5.00
158 INT99911 Localization of MTX1 5 0.45 3.81 3.07 5.00
159 INT181386 Positive_regulation of Cxcl12 12 0.69 15.35 2.84 5.00
160 INT94437 Positive_regulation of Gene_expression of OLR1 17 0.70 16.04 2.8 5.00
161 INT38673 Negative_regulation of KRT20 38 0.42 22.49 2.77 5.00
162 INT24895 Positive_regulation of LYZ 25 0.70 17.92 2.64 5.00
163 INT19430 Positive_regulation of IGHA1 10 0.67 6.42 2.58 5.00
164 INT182224 Binding of CCL21 6 0.34 5.91 2.54 5.00
165 INT109968 Positive_regulation of Positive_regulation of Trp53 6 0.47 3.57 2.51 5.00
166 INT169765 Gene_expression of Mir16-1 6 0.63 3.21 2.47 5.00
167 INT4879 Positive_regulation of Gene_expression of MME 17 0.69 12.48 2.46 5.00
168 INT100399 Gene_expression of CCL17 22 0.77 9.38 2.43 5.00
169 INT182238 Binding of CXCL13 5 0.33 5.32 2.37 5.00
170 INT26434 Localization of MME 17 0.81 8.67 2.3 5.00
171 INT54615 Gene_expression of GPER 25 0.75 8.23 2.27 5.00
172 INT92388 Gene_expression of ALK 16 0.78 22.46 2.26 5.00
173 INT175388 Localization of Ugcg 22 0.37 13.84 2.24 5.00
174 INT132903 Gene_expression of Cd34 65 0.72 33.95 2.2 5.00
175 INT38674 Regulation of KRT20 32 0.44 19 2.15 5.00
176 INT55470 Regulation of Mtor 16 0.24 12.51 2.07 5.00
177 INT106604 Protein_catabolism of CIB1 4 0.90 1.24 1.98 5.00
178 INT20388 Binding of LYZ 8 0.39 5.65 1.93 5.00
179 INT98782 Gene_expression of Cdkn1b 70 0.75 36.43 1.9 5.00
180 INT62692 Localization of Nanog 3 0.73 0.82 1.85 5.00
181 INT46142 Gene_expression of Chka 18 0.19 16.4 1.84 5.00
182 INT126457 Gene_expression of BCL6 34 0.66 22.45 1.75 5.00
183 INT205266 Regulation of Gene_expression of Plec 3 0.57 1.45 1.74 5.00
184 INT114490 Gene_expression of PDLIM7 17 0.78 11.35 1.42 5.00
185 INT172953 Binding of Trp53 33 0.37 20.76 1.41 5.00
186 INT155036 Localization of NT5E 6 0.73 4.1 1.35 5.00
187 INT29898 Negative_regulation of C6orf25 16 0.29 9.58 1.33 5.00
188 INT100582 Positive_regulation of Stil 2 0.49 1.69 1.33 5.00
189 INT276331 Gene_expression of Il22ra1 6 0.46 6.88 1.31 5.00
190 INT137382 Negative_regulation of Gene_expression of KRT20 22 0.58 12.29 1.29 5.00
191 INT154057 Gene_expression of Ear1 14 0.41 9.72 1.12 5.00
192 INT3046 Gene_expression of LGALS1 20 0.75 12.48 1.11 5.00
193 INT204170 Binding of Mri1 5 0.22 4.45 1.11 5.00
194 INT70021 Localization of BCL2 23 0.74 21.6 1.09 5.00
195 INT211095 Negative_regulation of Dag1 14 0.57 7.18 1.07 5.00
196 INT183933 Binding of CD68 8 0.31 8.74 1.06 5.00
197 INT90240 Gene_expression of MYOG 19 0.75 10 1.06 5.00
198 INT151774 Positive_regulation of Mtor 38 0.45 20.15 1.01 5.00
199 INT125960 Gene_expression of Ptprs 8 0.78 2.87 0.99 5.00
200 INT161591 Positive_regulation of CD163 5 0.48 3.9 0.98 5.00
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