D:Causalgia

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Disease Term
Synonyms Causalgia Disorder, Causalgia Syndrome, Causalgia Syndromes, Complex Regional Pain Syndrome Type Ii, Crps Complex Regional Pain Syndrome Type Ii, Crps Type Ii, DEAFFERENTATION PAIN, PAIN DEAFFERENTATION, Syndrome Causalgia, Syndromes Causalgia, TRAUMATIC ERYTHROMELALGIA
Documents 640
Hot Single Events 23
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Causalgia. They are ordered first by their relevance to Causalgia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT98117 Gdnf Regulation of SCN11A 1 0.05 0.39 0.5 50.40
2 INT98116 Gdnf Regulation of SCN10A 1 0.03 0.39 0.5 50.40
3 INT98119 Gdnf Regulation of SCN10A 1 0.01 0.34 0.45 49.92
4 INT98118 Gdnf Regulation of SCN11A 1 0.01 0.34 0.45 49.92
5 INT98121 Ngf Regulation of SCN11A 1 0.07 0.29 0.39 46.80
6 INT98120 Ngf Regulation of SCN10A 1 0.04 0.29 0.39 46.80
7 INT335405 Binding of Arntl and Npas2 1 0.28 1.82 1.61 5.00
8 INT326194 Bdnf Regulation of Slc12a5 1 0.05 0.85 1.35 5.00
9 INT335401 Hgf Positive_regulation of Ngf 1 0.30 1.13 1.04 5.00
10 INT335404 Binding of Arntl and Hspg2 1 0.06 0.93 0.82 5.00
11 INT335403 Binding of Hspg2 and Npas2 1 0.04 0.93 0.82 5.00
12 INT326193 Bdnf Positive_regulation of Car2 2 0.14 0.11 0.62 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Causalgia. They are ordered first by their pain relevance and then by number of times they were reported in Causalgia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT19771 Positive_regulation of PAG1 69 0.61 75.61 76.88 99.96
2 INT15674 Positive_regulation of Gene_expression of Tac1 17 0.68 4.97 6.56 99.16
3 INT98111 Negative_regulation of Gdnf 12 0.59 10.85 9.29 98.92
4 INT98112 Positive_regulation of Negative_regulation of Gdnf 1 0.05 0.44 0.57 98.92
5 INT11773 Gene_expression of Tac1 56 0.77 10 25.72 98.64
6 INT57638 Positive_regulation of M1 7 0.40 6.08 5.03 97.68
7 INT69951 Binding of Cgnz1 3 0.25 1.82 1.64 97.00
8 INT5118 Regulation of SST 97 0.62 34.35 51.74 96.84
9 INT47540 Binding of Cp 20 0.41 15.54 7.01 96.44
10 INT167070 Positive_regulation of Gene_expression of MCS 3 0.30 3.75 1.48 96.44
11 INT62509 Gene_expression of MCS 58 0.67 21.46 6.57 95.68
12 INT5680 Gene_expression of Ngf 530 0.78 264.29 310.56 95.64
13 INT16254 Positive_regulation of Gene_expression of Ngf 144 0.70 80.61 82.08 95.64
14 INT100965 Positive_regulation of Nav1 85 0.70 37.74 75.35 94.16
15 INT19086 Negative_regulation of COL1A1 32 0.38 16.77 5.98 92.88
16 INT1665 Positive_regulation of Pag1 270 0.68 186.63 229.87 92.88
17 INT104986 Positive_regulation of CLS 3 0.40 0.65 0.41 91.44
18 INT109297 Negative_regulation of WSN 3 0.05 2.13 1.31 90.92
19 INT146349 Gene_expression of CLS 2 0.57 2.93 0 90.24
20 INT21940 Positive_regulation of CALR 15 0.40 17.42 0.95 89.76
21 INT16256 Regulation of Ntf3 15 0.49 9.75 13.07 89.12
22 INT14506 Regulation of Sst 46 0.62 15.02 22.66 85.92
23 INT39518 Negative_regulation of HBN1 66 0.09 37.54 2.58 83.88
24 INT97368 Negative_regulation of Nav1 62 0.59 41.56 60.27 76.68
25 INT141841 Negative_regulation of Transcription of Nav1 3 0.43 3.15 4.38 76.68
26 INT44642 Positive_regulation of Positive_regulation of T2 1 0.11 1.67 0.08 76.60
27 INT117675 Transcription of Nav1 46 0.72 30.23 44.01 76.16
28 INT4991 Positive_regulation of Vim 74 0.69 69.84 8.33 75.00
29 INT44643 Positive_regulation of T2 2 0.11 1.65 0.07 74.92
30 INT15276 Binding of Tac1 6 0.36 0.56 3.16 73.92
31 INT53068 Negative_regulation of Binding of Tac1 1 0.42 0.47 0.36 73.92
32 INT12359 Negative_regulation of Tac1 26 0.58 8.16 6.89 73.04
33 INT21941 Regulation of CALR 7 0.53 3.88 1.96 65.04
34 INT145971 Localization of Nav1 20 0.81 10.3 18.11 62.92
35 INT266565 Positive_regulation of Localization of Nav1 1 0.36 1.24 0.89 62.92
36 INT11980 Positive_regulation of Tac1 27 0.69 6.17 14.5 60.80
37 INT49139 Positive_regulation of Positive_regulation of Tac1 4 0.68 1.74 2.24 60.80
38 INT113925 Localization of Bdnf 59 0.79 24.03 22.76 55.76
39 INT97367 Gene_expression of Nav1 243 0.78 132.97 286.66 54.52
40 INT81229 Binding of COL1A1 24 0.35 12.07 3.3 53.00
41 INT12358 Regulation of Gene_expression of Tac1 17 0.60 3.34 8.84 52.24
42 INT66040 Positive_regulation of Bdnf 114 0.69 67.67 51.81 37.36
43 INT7697 Positive_regulation of Adra1a 22 0.68 2.3 9.16 31.92
44 INT17561 Localization of Car2 303 0.79 60.95 44.52 29.12
45 INT74051 Negative_regulation of Localization of Car2 27 0.38 9.58 5.1 29.12
46 INT97366 Regulation of Nav1 38 0.62 23.63 38.17 25.52
47 INT4894 Transcription of Ppt1 34 0.67 5.93 21.06 25.00
48 INT11979 Transcription of Tac4 42 0.52 4.48 20.95 25.00
49 INT127203 Positive_regulation of Mcf2l 14 0.43 9.84 7.03 25.00
50 INT62510 Positive_regulation of MCS 32 0.60 11.79 5.45 25.00
51 INT53069 Regulation of Transcription of Tac4 4 0.23 0.49 2.36 25.00
52 INT4889 Regulation of Transcription of Ppt1 3 0.35 0.89 1.34 25.00
53 INT92669 Gene_expression of Bdnf 309 0.78 178.26 116.68 10.08
54 INT334332 Protein_catabolism of SPARCL1 1 0.01 1.65 0.15 7.12
55 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 5.00
56 INT4758 Positive_regulation of Localization of Calca 557 0.70 138.55 411.04 5.00
57 INT2649 Regulation of Calca 433 0.62 146.05 330.95 5.00
58 INT4941 Positive_regulation of Oprd1 345 0.70 74.26 304.41 5.00
59 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66 5.00
60 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02 5.00
61 INT14843 Gene_expression of Gabrg1 301 0.77 62.63 139.16 5.00
62 INT64201 Negative_regulation of Trpv1 203 0.59 79.18 119.75 5.00
63 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 5.00
64 INT82878 Gene_expression of Ccl2 201 0.78 164.95 101.35 5.00
65 INT17459 Positive_regulation of Gene_expression of FOS 182 0.67 53.45 96.38 5.00
66 INT38731 Localization of Trpv1 138 0.81 52.73 90.49 5.00
67 INT14049 Positive_regulation of GRIN1 102 0.70 48.31 71.06 5.00
68 INT171145 Positive_regulation of Fig4 274 0.59 93.55 69.81 5.00
69 INT55224 Gene_expression of DRGX 99 0.31 67.55 67.63 5.00
70 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9 5.00
71 INT6623 Gene_expression of NA 231 0.78 45.78 59.36 5.00
72 INT170646 Negative_regulation of Fig4 213 0.37 81.29 46.92 5.00
73 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
74 INT82883 Positive_regulation of Ccl2 105 0.69 84.96 42.27 5.00
75 INT8837 Positive_regulation of TAC1 59 0.67 21.94 35.97 5.00
76 INT666 Gene_expression of Jun 124 0.78 54.61 33.67 5.00
77 INT84170 Positive_regulation of Gene_expression of Ccl2 58 0.69 48.79 32.43 5.00
78 INT6660 Positive_regulation of Jun 148 0.69 67.58 29.73 5.00
79 INT72252 Gene_expression of Kcnma1 63 0.64 20.47 29.56 5.00
80 INT82882 Localization of Ccl2 61 0.80 41.96 28 5.00
81 INT177581 Regulation of Fig4 113 0.41 39.26 27.75 5.00
82 INT115909 Positive_regulation of Gene_expression of Nav1 25 0.70 16.58 27.63 5.00
83 INT14690 Localization of CSF2 124 0.80 85.17 27.26 5.00
84 INT64076 Positive_regulation of Kcnma1 47 0.40 11.52 24.19 5.00
85 INT117674 Regulation of Gene_expression of Nav1 16 0.62 11.5 22.01 5.00
86 INT11157 Binding of EGF 88 0.48 53.73 21.25 5.00
87 INT163479 Binding of Bdnf 36 0.48 25.77 14.83 5.00
88 INT58852 Positive_regulation of Enc1 20 0.49 7.51 13.25 5.00
89 INT74838 Positive_regulation of Sorbs1 18 0.34 6.93 12.63 5.00
90 INT158124 Gene_expression of COL5A2 136 0.69 72.3 12.44 5.00
91 INT118755 Gene_expression of Per2 12 0.68 2.81 11.41 5.00
92 INT37541 Gene_expression of SPP1 113 0.77 68.54 11.35 5.00
93 INT14334 Negative_regulation of Il2 31 0.58 18.63 11.08 5.00
94 INT113317 Regulation of Cnr2 17 0.52 10.27 10.68 5.00
95 INT94199 Regulation of DRGX 9 0.07 8.31 10.39 5.00
96 INT19132 Gene_expression of CYP27A1 83 0.75 34.31 10.17 5.00
97 INT110633 Binding of Nav1 15 0.42 4.34 9.38 5.00
98 INT1925 Gene_expression of PLAT 47 0.75 34.76 7.88 5.00
99 INT117676 Positive_regulation of Transcription of Nav1 8 0.53 4.37 7.75 5.00
100 INT79168 Binding of TNC 39 0.47 16.51 7.55 5.00
101 INT121419 Localization of Cnr2 11 0.80 4.98 7.14 5.00
102 INT95117 Gene_expression of PDGFA 71 0.71 51.17 6.9 5.00
103 INT85145 Negative_regulation of Cnr2 10 0.44 4.1 6.75 5.00
104 INT87941 Negative_regulation of DRGX 11 0.13 7.14 6.74 5.00
105 INT23465 Gene_expression of S100b 31 0.76 15.09 6.2 5.00
106 INT26555 Regulation of Positive_regulation of Oprd1 6 0.59 2.47 5.76 5.00
107 INT142690 Positive_regulation of Gene_expression of DRGX 10 0.23 8.54 5.69 5.00
108 INT174851 Positive_regulation of COL5A2 46 0.54 12.73 5.48 5.00
109 INT106555 Binding of Ntrk2 15 0.48 6.31 5.05 5.00
110 INT100991 Gene_expression of HOMER1 12 0.67 6.96 4.98 5.00
111 INT146091 Negative_regulation of IFNAR1 6 0.25 9.12 4.86 5.00
112 INT72538 Negative_regulation of Sorbs1 7 0.59 4.49 4.61 5.00
113 INT71716 Binding of Hbegf 21 0.28 6.54 4.51 5.00
114 INT19965 Positive_regulation of COL1A1 23 0.45 14.49 4.38 5.00
115 INT153194 Positive_regulation of Positive_regulation of Nav1 5 0.50 3.44 4.24 5.00
116 INT49191 Gene_expression of IFNAR1 14 0.41 9.96 3.84 5.00
117 INT82876 Regulation of IFNAR1 6 0.26 6.69 3.73 5.00
118 INT173751 Transcription of Fig4 31 0.46 8.28 3.7 5.00
119 INT14947 Localization of SPARCL1 7 0.46 11.97 3.6 5.00
120 INT41428 Binding of Vom2r2 4 0.32 1.26 3.35 5.00
121 INT22375 Localization of PDGFA 21 0.75 15.46 3.25 5.00
122 INT112640 Positive_regulation of Negative_regulation of Nav1 3 0.50 1.26 2.98 5.00
123 INT165590 Negative_regulation of Slc12a5 5 0.43 2.62 2.96 5.00
124 INT259760 Localization of Fbn2 5 0.05 5.55 2.85 5.00
125 INT133144 Localization of Mtpn 18 0.24 7.88 2.77 5.00
126 INT91013 Binding of IFNAR1 9 0.46 8.7 2.74 5.00
127 INT207366 Negative_regulation of Gene_expression of CYP27A1 11 0.44 4.82 2.67 5.00
128 INT163962 Regulation of Transcription of Nav1 2 0.35 3.25 2.63 5.00
129 INT67318 Positive_regulation of Hgf 13 0.69 5.47 2.6 5.00
130 INT259762 Positive_regulation of Fbn2 4 0.05 6.74 2.55 5.00
131 INT262339 Positive_regulation of TRIP10 2 0.26 2.07 2.5 5.00
132 INT158123 Negative_regulation of Gene_expression of COL5A2 19 0.46 15.27 2.23 5.00
133 INT85878 Negative_regulation of Il12a 4 0.58 2.88 2.21 5.00
134 INT266570 Positive_regulation of Binding of Nav1 3 0.44 1.45 2.2 5.00
135 INT87497 Positive_regulation of Cadps 2 0.22 1.77 2.19 5.00
136 INT75939 Positive_regulation of SPARCL1 6 0.28 8.74 2.11 5.00
137 INT335387 Gene_expression of Srd5a2 1 0.50 2.03 2.04 5.00
138 INT209596 Gene_expression of GRIK1 2 0.65 0.35 1.69 5.00
139 INT254045 Gene_expression of TRIP10 4 0.29 3.04 1.67 5.00
140 INT48074 Negative_regulation of Cadps 3 0.34 0.74 1.57 5.00
141 INT125767 Positive_regulation of Gene_expression of S100b 6 0.49 4.08 1.52 5.00
142 INT326192 Negative_regulation of Binding of Ntrk2 1 0.10 1 1.47 5.00
143 INT335363 Negative_regulation of Negative_regulation of Nmur2 1 0.18 2.31 1.44 5.00
144 INT104250 Positive_regulation of Gene_expression of SPP1 17 0.69 13.22 1.44 5.00
145 INT290803 Binding of Arntl 10 0.37 1.82 1.34 5.00
146 INT326191 Localization of Slc12a5 1 0.14 0.85 1.32 5.00
147 INT95116 Negative_regulation of PDGFA 24 0.57 19.56 1.29 5.00
148 INT14946 Binding of SPARCL1 5 0.31 6.57 1.29 5.00
149 INT210392 Regulation of PDGFA 10 0.36 11.41 1.12 5.00
150 INT335383 Positive_regulation of Srd5a2 1 0.37 1.04 1.12 5.00
151 INT335388 Positive_regulation of Slc30a3 1 0.49 1.04 1.11 5.00
152 INT112095 Negative_regulation of Nmur2 2 0.43 1.49 1.1 5.00
153 INT280858 Localization of IFNAR1 5 0.39 4.5 1.09 5.00
154 INT100992 Regulation of Gene_expression of HOMER1 2 0.10 0.74 1.06 5.00
155 INT262340 Binding of TRIP10 6 0.36 1.45 0.96 5.00
156 INT335360 Positive_regulation of Gene_expression of Per2 1 0.49 1.03 0.92 5.00
157 INT266561 Negative_regulation of Positive_regulation of Sorbs1 1 0.01 1.01 0.88 5.00
158 INT335369 Gene_expression of Npas2 1 0.54 0.92 0.86 5.00
159 INT335378 Negative_regulation of Gene_expression of Npas2 1 0.40 0.92 0.86 5.00
160 INT266562 Gene_expression of Fbn2 1 0.05 0.93 0.84 5.00
161 INT266563 Positive_regulation of Gene_expression of Fbn2 1 0.04 0.93 0.84 5.00
162 INT266567 Regulation of Localization of Nav1 1 0.21 1.89 0.83 5.00
163 INT335364 Negative_regulation of Transcription of Hspg2 1 0.07 0.91 0.8 5.00
164 INT282299 Positive_regulation of ADCY8 2 0.49 0.75 0.78 5.00
165 INT335373 Transcription of Hspg2 1 0.08 0.86 0.77 5.00
166 INT277239 Regulation of Bcl6 2 0.35 0.54 0.76 5.00
167 INT147008 Negative_regulation of Gene_expression of S100b 2 0.27 0.55 0.74 5.00
168 INT335368 Positive_regulation of Il22ra2 1 0.53 0.94 0.73 5.00
169 INT335359 Positive_regulation of Gene_expression of Psip1 1 0.59 0.85 0.7 5.00
170 INT335367 Gene_expression of Psip1 1 0.66 0.85 0.7 5.00
171 INT282300 Regulation of Positive_regulation of ADCY8 1 0.12 0.68 0.69 5.00
172 INT282302 Regulation of TRIP10 1 0.23 0.39 0.67 5.00
173 INT89520 Regulation of COL1A1 8 0.32 3.21 0.66 5.00
174 INT169589 Gene_expression of Cd7 2 0.44 1.49 0.65 5.00
175 INT216770 Gene_expression of Cadps 3 0.34 0.86 0.6 5.00
176 INT335379 Gene_expression of Lgals2 1 0.56 0.78 0.6 5.00
177 INT335375 Negative_regulation of Btk 1 0.22 0.56 0.59 5.00
178 INT335380 Negative_regulation of Bcl6 1 0.27 0.56 0.59 5.00
179 INT335374 Regulation of Btk 1 0.23 0.54 0.58 5.00
180 INT335370 Gene_expression of Il22 1 0.45 0.71 0.56 5.00
181 INT335376 Negative_regulation of Zhx2 1 0.33 0.81 0.51 5.00
182 INT335384 Positive_regulation of Gene_expression of Zhx2 1 0.53 0.79 0.45 5.00
183 INT335382 Gene_expression of Zhx2 1 0.59 0.79 0.45 5.00
184 INT175759 Gene_expression of ARNTL 9 0.75 0.8 0.44 5.00
185 INT282303 Positive_regulation of Gene_expression of TRIP10 1 0.17 0.46 0.39 5.00
186 INT266569 Negative_regulation of Gene_expression of Cadps 1 0.13 0.51 0.37 5.00
187 INT335365 Positive_regulation of Lgals2 1 0.42 0.58 0.36 5.00
188 INT266564 Negative_regulation of Protein_catabolism of Nav1 1 0.29 0.42 0.34 5.00
189 INT259761 Negative_regulation of Fbn2 2 0.03 1.1 0.34 5.00
190 INT282301 Regulation of Gene_expression of TRIP10 1 0.23 0.3 0.34 5.00
191 INT266568 Protein_catabolism of Nav1 1 0.44 0.41 0.33 5.00
192 INT308015 Phosphorylation of IFNAR1 1 0.27 1.11 0.28 5.00
193 INT266560 Positive_regulation of Positive_regulation of Fbn2 1 0.05 0.5 0.26 5.00
194 INT266566 Regulation of Transcription of Fig4 2 0.11 0.56 0.23 5.00
195 INT335357 Binding of Lrrc10 1 0.47 0.34 0.21 5.00
196 INT335371 Binding of Lrrfip1 1 0.35 0.34 0.21 5.00
197 INT335377 Localization of Psip1 1 0.63 0.3 0.2 5.00
198 INT97473 Positive_regulation of FAP 4 0.34 2.72 0.18 5.00
199 INT335386 Localization of Bcl6 1 0.39 0.23 0.16 5.00
200 INT335362 Localization of Btk 1 0.36 0.23 0.16 5.00
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