D:Central Core Disease

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Disease Term
Synonyms Central Core Diseases, Central Core Myopathies, CENTRAL CORE MYOPATHY, Myopathies Central Core, Myopathy Central Core, SHY MAGEE SYNDROME, Shy S Disease, Syndrome Shy Magee
Documents 30
Hot Single Events 14
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Central Core Disease. They are ordered first by their relevance to Central Core Disease and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT266703 Binding of RYR1 and DIXDC1 1 0.26 0.1 0 100.00
2 INT207785 Binding of RYR1 and Ap3d1 1 0.06 3.24 0.13 97.20
3 INT207783 Binding of MRC1 and Ap3d1 1 0.00 2.54 0.22 29.84
4 INT207776 Binding of FKBP1A and RYR1 1 0.05 0.59 0.12 12.44
5 INT271071 Binding of ACTA1 and Hypism 1 0.00 1.54 0.15 6.72
6 INT204943 Il6 Regulation of Slc39a14 1 0.00 0.54 0.36 5.00
7 INT331966 Binding of DES and SACM1L 1 0.01 1.86 0.36 5.00
8 INT207784 Ap3d1 Regulation of CACNA1S 1 0.05 0.97 0.16 5.00
9 INT266704 Binding of RYR1 and TRDN 1 0.34 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Central Core Disease. They are ordered first by their pain relevance and then by number of times they were reported in Central Core Disease. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT207777 Binding of Ap3d1 1 0.07 14.51 1.91 99.80
2 INT207779 Localization of Ap3d1 1 0.11 3.16 0.14 99.80
3 INT59555 Binding of RYR1 39 0.42 8.65 4.92 99.48
4 INT11713 Localization of RYR1 22 0.76 10.42 1.64 99.36
5 INT211758 Binding of Mmd 1 0.13 3.09 0.1 98.54
6 INT28320 Negative_regulation of Abo 16 0.58 5.69 4.7 97.36
7 INT211756 Phosphorylation of Mmd 1 0.17 1.44 0.03 96.44
8 INT107987 Gene_expression of MRC1 27 0.75 36.94 1.99 94.08
9 INT21855 Gene_expression of Ap3d1 4 0.32 12.21 4.66 92.88
10 INT245157 Negative_regulation of Gene_expression of DMD 8 0.57 4.79 0.09 90.20
11 INT13396 Gene_expression of DMD 125 0.75 57.81 5.45 89.88
12 INT68500 Regulation of Ar 6 0.27 4.16 1.32 85.84
13 INT55305 Regulation of RYR1 14 0.45 5.27 1.33 82.08
14 INT24712 Positive_regulation of Ap3d1 18 0.54 8.58 2.71 81.92
15 INT36040 Localization of Itpr3 21 0.70 4.87 7.77 79.52
16 INT17561 Localization of Car2 303 0.79 60.95 44.52 76.48
17 INT207778 Positive_regulation of Binding of Ap3d1 1 0.06 1.26 0.52 75.12
18 INT211757 Negative_regulation of Mmd 1 0.11 1.02 0.08 74.60
19 INT60209 Transcription of RYR1 3 0.69 3.06 0.16 73.80
20 INT3537 Positive_regulation of Car2 413 0.56 103.51 94.35 71.44
21 INT16167 Negative_regulation of DMD 186 0.57 108.71 15.25 60.64
22 INT42425 Gene_expression of Mmd 2 0.75 1.68 0.91 60.48
23 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 43.44
24 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 43.44
25 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 43.04
26 INT207782 Binding of CACNA1S 1 0.30 0.53 0.03 42.00
27 INT49908 Regulation of Gene_expression of RYR1 3 0.45 0.32 0.19 39.00
28 INT211753 Negative_regulation of ACADS 1 0.03 1.49 0.08 38.96
29 INT6508 Gene_expression of RYR1 34 0.77 11.11 2.04 38.56
30 INT17962 Regulation of Car2 124 0.41 33.98 22.71 35.28
31 INT11937 Localization of Il6 228 0.81 139.83 64.39 31.44
32 INT121774 Binding of ACTA1 4 0.47 2.31 0.85 20.96
33 INT82913 Regulation of Ppara 15 0.61 10.66 3.03 17.68
34 INT98607 Regulation of Regulation of TNF 8 0.44 6.95 2.56 17.68
35 INT9660 Regulation of TNF 363 0.62 312.94 139.99 15.76
36 INT65057 Regulation of Nfkb1 28 0.47 16.48 11.62 14.60
37 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
38 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66 5.00
39 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
40 INT8357 Gene_expression of KNG1 153 0.75 77.26 68.66 5.00
41 INT11491 Positive_regulation of KNG1 128 0.67 60.41 58.74 5.00
42 INT17458 Negative_regulation of Gene_expression of FOS 98 0.57 36.77 55.69 5.00
43 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
44 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 5.00
45 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 5.00
46 INT9655 Regulation of Il6 98 0.62 70.92 31.95 5.00
47 INT58192 Positive_regulation of MRI1 86 0.61 53.81 24.68 5.00
48 INT11938 Positive_regulation of Localization of Il6 61 0.70 35.72 18.25 5.00
49 INT20631 Positive_regulation of CHKB 166 0.69 109.86 17.92 5.00
50 INT171666 Regulation of GOPC 117 0.39 40.41 15.47 5.00
51 INT180497 Binding of MRI1 45 0.42 28.35 14.77 5.00
52 INT70265 Regulation of MRI1 42 0.39 30.95 14.18 5.00
53 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83 5.00
54 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 5.00
55 INT26551 Positive_regulation of Gene_expression of KNG1 19 0.67 11.05 7.98 5.00
56 INT14207 Gene_expression of DNM2 20 0.67 5.76 7.64 5.00
57 INT62336 Positive_regulation of Hdc 38 0.70 14.45 5.51 5.00
58 INT49375 Regulation of Localization of Il6 16 0.62 4.54 5.08 5.00
59 INT10138 Negative_regulation of Gene_expression of KNG1 13 0.57 9.57 4.9 5.00
60 INT57274 Positive_regulation of Gene_expression of COL7A1 50 0.69 24.19 4.72 5.00
61 INT15648 Positive_regulation of RYR1 30 0.67 12.03 3.26 5.00
62 INT26273 Negative_regulation of RYR1 18 0.43 7.64 3.11 5.00
63 INT21853 Regulation of Ap3d1 3 0.10 1.4 2.95 5.00
64 INT105824 Regulation of Casq1 4 0.07 2.66 2.1 5.00
65 INT21852 Regulation of Gene_expression of Ap3d1 2 0.18 1.34 1.54 5.00
66 INT71918 Gene_expression of ACTA1 16 0.75 7.73 1.45 5.00
67 INT11367 Localization of MB 9 0.78 9.34 1.24 5.00
68 INT207780 Positive_regulation of NMS 2 0.28 3.2 0.61 5.00
69 INT94347 Gene_expression of DYSF 4 0.75 3.25 0.41 5.00
70 INT2090 Negative_regulation of Gaa 5 0.21 3.43 0.4 5.00
71 INT331973 Gene_expression of MYOT 4 0.64 3.83 0.4 5.00
72 INT211586 Regulation of DMPK 6 0.31 2.11 0.33 5.00
73 INT204941 Protein_catabolism of Timp2 1 0.03 0.35 0.32 5.00
74 INT123637 Gene_expression of LGMD2I 2 0.08 1.7 0.29 5.00
75 INT260581 Binding of DMPK 7 0.43 5.09 0.28 5.00
76 INT264998 Regulation of Binding of MRI1 1 0.31 1.34 0.27 5.00
77 INT331969 Regulation of Gene_expression of MYOT 1 0.43 2.22 0.27 5.00
78 INT175417 Binding of SACM1L 8 0.29 6.06 0.22 5.00
79 INT331970 Regulation of Regulation of LDB3 1 0.37 1.12 0.14 5.00
80 INT179320 Regulation of LDB3 3 0.37 1.55 0.14 5.00
81 INT331968 Positive_regulation of Gene_expression of SEPN1 1 0.31 1 0.13 5.00
82 INT289892 Gene_expression of SEPN1 3 0.42 1.17 0.13 5.00
83 INT158175 Positive_regulation of Gene_expression of RYR1 2 0.48 1.35 0.13 5.00
84 INT88416 Positive_regulation of Gene_expression of ACTA1 2 0.67 1.05 0.13 5.00
85 INT331971 Positive_regulation of Gene_expression of DNM2 1 0.31 1 0.13 5.00
86 INT331967 Negative_regulation of LGMD2A 1 0.06 0.48 0.11 5.00
87 INT331972 Positive_regulation of Gene_expression of DYSF 1 0.28 0.48 0.11 5.00
88 INT166811 Regulation of Casq1 3 0.04 1.18 0.1 5.00
89 INT272205 Positive_regulation of LGMD2I 2 0.12 2.08 0.08 5.00
90 INT207781 Gene_expression of CACNA1S 3 0.63 0.9 0.03 5.00
91 INT266731 Binding of TRDN 1 0.47 0 0.03 5.00
92 INT204938 Positive_regulation of Casq1 1 0.08 0.17 0.03 5.00
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