D:Central Nervous System Cancer

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Disease Term
Synonyms Cancer Of The Central Nervous System, Cancers Of The Central Nervous System, CENTRAL NERVOUS SYSTEM CANCERS, Central Nervous System Carcinoma, CENTRAL NERVOUS SYSTEM CARCINOMAS, Central Nervous System Dysplasia, CENTRAL NERVOUS SYSTEM HYPERPLASIA, Central Nervous System Neoplasia, CENTRAL NERVOUS SYSTEM NEOPLASM, Central Nervous System Neoplasms, Central Nervous System Neoplasms Primary
Documents 95
Hot Single Events 12
Hot Interactions 3

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Central Nervous System Cancer. They are ordered first by their relevance to Central Nervous System Cancer and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT188737 Egfr Positive_regulation of EGFR 1 0.21 0.6 0.04 84.36
2 INT188735 EGFR Positive_regulation of Egfr 1 0.21 0.6 0.04 84.36
3 INT188732 EGFR Positive_regulation of Gene_expression of Egfr 1 0.21 0.6 0.04 84.36
4 INT225230 Ad Positive_regulation of Nf2 1 0.04 1.37 0.04 77.00
5 INT188736 Egfr Regulation of IGLV3-1 1 0.46 0.59 0.03 62.68
6 INT188731 Egfr Regulation of EGFR 1 0.46 0.59 0.03 62.68
7 INT264731 Gene_expression of Hes1 Negative_regulation of Positive_regulation of Musd1 1 0.00 0.18 0 38.04
8 INT225228 Binding of Cdk4 and Cdkn2a 1 0.21 1.24 0 27.60
9 INT225229 Binding of Cdk6 and Cdkn2a 1 0.19 1.25 0 27.60
10 INT321578 Binding of Plaur and Positive_regulation of Ctsb 1 0.15 0.92 0.12 17.76
11 INT173120 Binding of PPARA and NR1H4 8 0.09 2.79 0.23 5.00
12 INT302295 PPARA Regulation of OAS2 1 0.01 0.72 0.17 5.00
13 INT321580 Plaur Regulation of Ctsb 1 0.09 0.53 0 5.00
14 INT188733 Egfr Positive_regulation of Gene_expression of IGLV3-1 1 0.52 0.61 0 5.00
15 INT264735 Binding of Hes1 and Mir199b 1 0.08 0.93 0 5.00
16 INT264697 Binding of Hes1 and Mir199b Regulation of Notch1 1 0.00 0.86 0 5.00
17 INT264738 Mir199b Regulation of Gene_expression of Hes1 1 0.08 0.89 0 5.00
18 INT260025 PROM1 Positive_regulation of Gene_expression of NES 1 0.56 0.74 0 5.00
19 INT264736 Hes1 Regulation of Notch2 1 0.20 0.13 0 5.00
20 INT302303 Binding of NR1H4 and Rdh5 1 0.02 0.11 0 5.00
21 INT264727 Binding of Notch1 and Mir199b 1 0.00 0.86 0 5.00
22 INT321581 Plaur Regulation of Mmp9 1 0.14 0.53 0 5.00
23 INT264732 Binding of Gtf3a and Mir199b 1 0.00 0.86 0 5.00
24 INT264728 Mir199b Regulation of Notch1 1 0.01 0.85 0 5.00
25 INT188734 Egfr Positive_regulation of Gene_expression of EGFR 1 0.52 0.61 0 5.00
26 INT264726 Binding of Notch1 and Gtf3a 1 0.00 1.68 0 5.00
27 INT264729 Mir199b Regulation of Hes1 1 0.05 0.25 0 5.00
28 INT264725 Binding of Hes1 and Notch1 1 0.03 0.84 0 5.00
29 INT300631 Binding of TSC1 and TSC2 1 0.15 2.59 0 5.00
30 INT264734 Mir199b Negative_regulation of Negative_regulation of Hes1 1 0.07 0.1 0 5.00
31 INT260024 PROM1 Positive_regulation of NES 1 0.56 0.73 0 5.00
32 INT264739 Mir199b Negative_regulation of Gene_expression of Hes1 1 0.07 0.82 0 5.00
33 INT264737 Hes1 Regulation of Shh 1 0.19 0.13 0 5.00
34 INT264733 Hes1 Regulation of Mir199b 1 0.05 0.43 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Central Nervous System Cancer. They are ordered first by their pain relevance and then by number of times they were reported in Central Nervous System Cancer. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT117660 Gene_expression of Prom1 50 0.73 39.62 3.07 99.76
2 INT73627 Binding of Fap 8 0.36 11.14 0.4 97.28
3 INT103094 Binding of PPARA 308 0.47 177.26 34.75 95.36
4 INT21609 Positive_regulation of RASGRP1 58 0.50 40.78 5.47 94.00
5 INT211972 Regulation of Best1 18 0.33 12.04 0.67 91.12
6 INT225221 Negative_regulation of Nf2 1 0.57 18.06 0.83 90.72
7 INT142435 Gene_expression of NES 86 0.78 47.53 4.92 90.28
8 INT139366 Gene_expression of PROM1 98 0.77 67.84 3.39 89.84
9 INT174156 Localization of Trp53 16 0.72 13.52 1.18 82.84
10 INT113705 Gene_expression of Egfr 228 0.78 149.05 7.59 81.64
11 INT225224 Positive_regulation of Nf2 1 0.59 3.4 0.12 80.72
12 INT58192 Positive_regulation of MRI1 86 0.61 53.81 24.68 80.52
13 INT6868 Gene_expression of GFAP 136 0.78 84.65 22.7 79.20
14 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 78.88
15 INT171233 Binding of Ecm1 25 0.07 12.41 3.36 77.28
16 INT27651 Gene_expression of S100A12 45 0.76 52.25 10.51 76.24
17 INT4988 Gene_expression of KRT1 64 0.77 43.4 4.12 75.04
18 INT10847 Gene_expression of LAMC2 39 0.75 27 12.09 75.00
19 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 75.00
20 INT6511 Positive_regulation of AFP 76 0.70 70.15 7.28 75.00
21 INT95636 Gene_expression of ACTG2 23 0.44 19.87 1.75 74.00
22 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 70.00
23 INT16478 Positive_regulation of Plg 29 0.45 18.07 4.07 66.52
24 INT115463 Positive_regulation of Plau 13 0.47 8.47 1.49 66.04
25 INT264709 Gene_expression of Hes1 24 0.76 7.04 0.63 64.96
26 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 64.72
27 INT188724 Gene_expression of IGLV3-1 29 0.75 20.88 0.51 64.72
28 INT259041 Binding of D18Tlj1e 1 0.03 1.98 0.57 64.28
29 INT264721 Positive_regulation of Mir199b 1 0.08 0.69 0.03 64.12
30 INT188725 Regulation of IGLV3-1 1 0.12 0.6 0.03 64.12
31 INT264717 Negative_regulation of Hes1 7 0.42 0.77 0.03 59.64
32 INT264704 Regulation of Hes1 4 0.44 1.03 0.03 59.64
33 INT131286 Binding of Egfr 26 0.44 13.58 0.78 57.16
34 INT5841 Gene_expression of Vim 181 0.72 138.54 16.33 55.84
35 INT20055 Gene_expression of CRTAC1 19 0.58 15.49 4.73 55.84
36 INT264702 Positive_regulation of Gene_expression of Hes1 1 0.68 1.39 0.03 52.88
37 INT211970 Negative_regulation of Best1 49 0.14 37.33 2.32 52.52
38 INT25962 Gene_expression of COX8A 25 0.75 20.04 2.62 51.88
39 INT134967 Gene_expression of Ecm1 66 0.29 38.4 7.16 51.00
40 INT8068 Gene_expression of RASGRP1 29 0.54 15.1 1.37 48.48
41 INT102572 Gene_expression of Ccnd1 79 0.69 56.37 7.34 46.08
42 INT92316 Gene_expression of Plaur 30 0.61 22.06 2.21 46.08
43 INT184473 Regulation of Gene_expression of Ccnd1 5 0.40 2.73 0.1 46.08
44 INT108327 Negative_regulation of Gene_expression of Ccnd1 18 0.38 14.36 1.31 46.04
45 INT225225 Negative_regulation of Gene_expression of Cyp2b10 2 0.29 2.43 0.27 44.12
46 INT183399 Gene_expression of Cyp2b10 17 0.39 18.39 0.71 43.80
47 INT264701 Negative_regulation of Gene_expression of Hes1 1 0.42 0.73 0.18 42.52
48 INT8066 Binding of RASGRP1 10 0.36 4.65 0.58 41.84
49 INT225223 Localization of Cdkn2b 2 0.62 1.29 0.37 40.52
50 INT196323 Localization of Cdkn2a 8 0.73 9.1 0.32 40.52
51 INT174052 Positive_regulation of Musd1 2 0.01 0.12 0 35.68
52 INT207081 Binding of Plaur 6 0.31 5.99 0.41 28.48
53 INT171716 Regulation of Fap 4 0.27 4.05 0.23 28.16
54 INT211969 Positive_regulation of Best1 34 0.11 14.92 1.44 22.72
55 INT169911 Phosphorylation of Rb1 35 0.73 18.58 0.79 21.88
56 INT65545 Localization of EGFR 35 0.79 20.8 1.88 20.56
57 INT188729 Localization of IGLV3-1 1 0.68 0.21 0 20.56
58 INT264700 Gene_expression of Mir199b 1 0.12 11.67 0.28 20.36
59 INT98065 Binding of Plau 5 0.12 2.39 0.52 17.92
60 INT321564 Positive_regulation of Protein_catabolism of Ctsb 1 0.16 0.92 0.12 17.24
61 INT235549 Gene_expression of Ctsb 19 0.58 8.61 0.2 16.64
62 INT321559 Regulation of Protein_catabolism of Ctsb 1 0.10 0.89 0.11 14.28
63 INT179810 Protein_catabolism of Ecm1 30 0.11 18.28 5.75 13.80
64 INT321566 Protein_catabolism of Ctsb 2 0.23 1.07 0.06 13.64
65 INT89 Positive_regulation of Gast 187 0.70 80.49 42.07 11.80
66 INT11802 Gene_expression of KLF1 11 0.65 6.81 1.41 5.84
67 INT1045 Localization of LH 1211 0.81 87.04 456.25 5.00
68 INT439 Localization of Gnrh1 976 0.81 100.96 363.25 5.00
69 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94 5.00
70 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
71 INT1047 Negative_regulation of LH 314 0.59 53.71 135.89 5.00
72 INT2106 Regulation of Localization of LH 279 0.62 22.37 122.77 5.00
73 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 5.00
74 INT90 Localization of Gast 400 0.81 137.67 113 5.00
75 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
76 INT2159 Regulation of Localization of Gnrh1 200 0.62 13.28 99.07 5.00
77 INT4289 Positive_regulation of Localization of Gnrh1 202 0.70 12.3 84.01 5.00
78 INT2123 Positive_regulation of Gnrh1 209 0.70 24.2 68.97 5.00
79 INT1046 Gene_expression of LH 180 0.77 29.75 66.87 5.00
80 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 5.00
81 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
82 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34 5.00
83 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 5.00
84 INT96937 Gene_expression of Mmp9 191 0.75 150.3 56.01 5.00
85 INT2197 Gene_expression of Gnrh1 184 0.78 40.04 50.57 5.00
86 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
87 INT25383 Gene_expression of Csf2 222 0.76 152.93 43.32 5.00
88 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 5.00
89 INT1361 Negative_regulation of Gnrhr 118 0.58 57.77 35.54 5.00
90 INT326 Gene_expression of Gnrhr 105 0.76 35.87 34.93 5.00
91 INT15174 Gene_expression of Itgam 238 0.73 104.92 29.26 5.00
92 INT66200 Gene_expression of Gfap 215 0.78 88.04 28.25 5.00
93 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 5.00
94 INT29 Negative_regulation of Gast 74 0.59 24.85 24.96 5.00
95 INT172458 Regulation of Gopc 155 0.53 62.57 24.86 5.00
96 INT101517 Negative_regulation of PPARA 168 0.57 112.24 21.41 5.00
97 INT14737 Gene_expression of FN1 117 0.78 78.74 18.99 5.00
98 INT95767 Negative_regulation of Mmp9 72 0.57 49.14 17.1 5.00
99 INT81627 Gene_expression of Fas 120 0.78 115.51 15.36 5.00
100 INT100139 Positive_regulation of Gene_expression of PPARA 160 0.63 97.78 14.53 5.00
101 INT37722 Gene_expression of NCAM1 103 0.75 81.57 14.18 5.00
102 INT27242 Gene_expression of PGR 153 0.75 98.77 12.79 5.00
103 INT28420 Gene_expression of Ptgds 59 0.78 31.72 12.67 5.00
104 INT19795 Positive_regulation of EGFR 161 0.70 103.69 11.55 5.00
105 INT57187 Positive_regulation of Gfap 49 0.69 27.59 11.46 5.00
106 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 5.00
107 INT173159 Localization of PPARA 96 0.74 64.55 10.26 5.00
108 INT591 Negative_regulation of Serpinc1 44 0.57 31.73 8.82 5.00
109 INT139613 Binding of pr 16 0.47 5.52 8.46 5.00
110 INT53487 Gene_expression of TSC1 81 0.58 77.71 7.94 5.00
111 INT111607 Gene_expression of CDH1 103 0.75 90.45 7.77 5.00
112 INT197447 Negative_regulation of Psmd1 12 0.33 4.33 7.66 5.00
113 INT76892 Gene_expression of FGFR1 45 0.69 23.6 7.56 5.00
114 INT96994 Phosphorylation of EGFR 99 0.82 52.75 7.33 5.00
115 INT1123 Positive_regulation of CD79A 74 0.70 51.96 7.14 5.00
116 INT168600 Binding of Mmp9 14 0.44 12.79 6.92 5.00
117 INT3500 Positive_regulation of Gene_expression of Gnrh1 25 0.69 4.59 6.69 5.00
118 INT173967 Gene_expression of Mri1 26 0.43 16.67 6.45 5.00
119 INT3819 Positive_regulation of Apc 36 0.69 27.03 6.02 5.00
120 INT123726 Positive_regulation of Notch1 23 0.70 7.2 5.65 5.00
121 INT112124 Positive_regulation of Egfr 71 0.70 47.82 5.61 5.00
122 INT6476 Gene_expression of TNFRSF1B 21 0.67 18.22 5.25 5.00
123 INT87022 Gene_expression of Apc 68 0.67 46.98 5.22 5.00
124 INT249561 Positive_regulation of Psmd1 12 0.37 7.32 5.06 5.00
125 INT10504 Localization of Pla2g1b 18 0.65 8.19 5.05 5.00
126 INT61252 Negative_regulation of Gene_expression of Itgam 38 0.54 16.48 5.01 5.00
127 INT11158 Positive_regulation of Gene_expression of EGFR 165 0.70 131.26 4.93 5.00
128 INT116464 Negative_regulation of Birc5 53 0.59 45.4 4.91 5.00
129 INT8336 Transcription of Gnrh1 22 0.71 4.37 4.69 5.00
130 INT205954 Regulation of Psmd1 8 0.33 3.72 4.52 5.00
131 INT75629 Gene_expression of Mtap2 41 0.66 8.19 4.51 5.00
132 INT69217 Gene_expression of Notch1 20 0.78 7.8 4.41 5.00
133 INT39000 Regulation of pr 24 0.44 12.51 4.36 5.00
134 INT103914 Phosphorylation of Egfr 35 0.82 16.98 4.31 5.00
135 INT115889 Binding of Fas 27 0.36 28.87 4.08 5.00
136 INT160915 Regulation of Mmp9 16 0.35 10.25 4.07 5.00
137 INT185246 Gene_expression of Psmd1 26 0.50 8.89 3.73 5.00
138 INT71602 Negative_regulation of Trp53 84 0.59 67.77 3.68 5.00
139 INT2220 Regulation of Gene_expression of Gnrh1 12 0.61 2.16 3.53 5.00
140 INT163832 Negative_regulation of Gene_expression of EGFR 50 0.59 39.71 3.45 5.00
141 INT117348 Regulation of EGFR 75 0.61 47.73 3.09 5.00
142 INT91173 Gene_expression of Pdgfrb 33 0.65 32.55 3.09 5.00
143 INT105985 Transcription of Mmp9 11 0.66 8.55 3.02 5.00
144 INT23367 Positive_regulation of Positive_regulation of Gnrh1 9 0.50 0.97 2.97 5.00
145 INT54072 Gene_expression of GAP43 14 0.67 5.04 2.83 5.00
146 INT139872 Regulation of Notch1 14 0.45 7.69 2.82 5.00
147 INT132575 Binding of NR1H4 57 0.20 22.06 2.82 5.00
148 INT221269 Binding of BRCA1 14 0.40 31.77 2.7 5.00
149 INT145328 Negative_regulation of Scrib 25 0.16 26.79 2.66 5.00
150 INT111298 Gene_expression of ACTN4 12 0.70 9.42 2.6 5.00
151 INT86815 Gene_expression of Pla2g2a 18 0.55 5.72 2.59 5.00
152 INT179788 Gene_expression of Sparc 42 0.77 19.96 2.57 5.00
153 INT15604 Gene_expression of FSHB 30 0.56 9.7 2.45 5.00
154 INT105761 Binding of GFAP 13 0.36 14.94 2.32 5.00
155 INT182318 Regulation of Birc5 25 0.60 23.58 2.29 5.00
156 INT177328 Positive_regulation of CXADR 9 0.48 4.29 2.27 5.00
157 INT103917 Positive_regulation of Phosphorylation of Egfr 12 0.68 7.23 2.18 5.00
158 INT79816 Localization of Pla2g2a 13 0.74 8.08 2.06 5.00
159 INT81641 Gene_expression of Ctnnb1 23 0.72 14.93 1.97 5.00
160 INT117980 Regulation of Rac1 10 0.45 3.72 1.88 5.00
161 INT56925 Negative_regulation of TSC1 54 0.52 63.39 1.87 5.00
162 INT105162 Gene_expression of Ad 47 0.12 46.53 1.83 5.00
163 INT120563 Positive_regulation of Gene_expression of Egfr 56 0.70 46.19 1.82 5.00
164 INT565 Negative_regulation of Cfb 18 0.13 6.77 1.69 5.00
165 INT146943 Gene_expression of Src 13 0.49 6.65 1.65 5.00
166 INT206471 Positive_regulation of Ptk2 34 0.51 25.75 1.61 5.00
167 INT15692 Regulation of HTC2 4 0.27 4.75 1.61 5.00
168 INT27671 Regulation of Transcription of Gnrh1 4 0.45 0.25 1.52 5.00
169 INT18156 Gene_expression of Fap 18 0.73 27.02 1.46 5.00
170 INT173162 Phosphorylation of PPARA 22 0.80 11.09 1.38 5.00
171 INT96993 Positive_regulation of Phosphorylation of EGFR 15 0.59 5.44 1.37 5.00
172 INT220177 Binding of Apc 21 0.37 15.34 1.37 5.00
173 INT214073 Binding of TSC1 9 0.37 22 1.34 5.00
174 INT110434 Positive_regulation of Gene_expression of Apc 20 0.50 11.37 1.3 5.00
175 INT214574 Positive_regulation of SDC1 4 0.32 3.24 1.28 5.00
176 INT81400 Binding of RARA 25 0.36 12.93 1.27 5.00
177 INT128987 Negative_regulation of Ccnd1 24 0.52 15.78 1.15 5.00
178 INT113865 Binding of CXADR 35 0.46 3.18 1.12 5.00
179 INT204170 Binding of Mri1 5 0.22 4.45 1.11 5.00
180 INT154795 Positive_regulation of Gene_expression of NES 8 0.49 1.49 1.05 5.00
181 INT177615 Gene_expression of PAX7 20 0.65 13.5 1.03 5.00
182 INT190031 Binding of Scrib 19 0.36 21.9 1.01 5.00
183 INT203445 Gene_expression of Hes7 3 0.03 2.93 0.96 5.00
184 INT242134 Localization of Apc 8 0.74 4.83 0.88 5.00
185 INT114875 Negative_regulation of Cdk4 4 0.35 4.01 0.86 5.00
186 INT109007 Positive_regulation of Ccnd1 23 0.53 9.5 0.86 5.00
187 INT287954 Gene_expression of DVL1 8 0.24 2.48 0.83 5.00
188 INT171361 Regulation of Egfr 16 0.62 8.36 0.81 5.00
189 INT74019 Regulation of TSC1 27 0.35 23.61 0.79 5.00
190 INT134207 Gene_expression of Ptk2 56 0.73 31.97 0.78 5.00
191 INT129115 Negative_regulation of Cdkn2a 16 0.50 17.03 0.76 5.00
192 INT259042 Gene_expression of D18Tlj1e 1 0.06 1.85 0.74 5.00
193 INT9559 Positive_regulation of Transcription of Gnrh1 1 0.69 0.82 0.66 5.00
194 INT136531 Binding of Men1 8 0.47 9.62 0.65 5.00
195 INT202848 Gene_expression of Nf2 5 0.59 4.93 0.63 5.00
196 INT32612 Negative_regulation of FSHB 3 0.41 2.17 0.58 5.00
197 INT111609 Gene_expression of CTNNA1 3 0.46 3.2 0.57 5.00
198 INT29619 Negative_regulation of Gene_expression of FSHB 5 0.05 0.59 0.57 5.00
199 INT134208 Negative_regulation of Ptk2 19 0.58 23.59 0.52 5.00
200 INT264716 Negative_regulation of Gene_expression of Sparc 6 0.43 3.16 0.51 5.00
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