D:Cerebellar Ataxia

From wiki-pain
Jump to: navigation, search

pChart

Disease Term
Synonyms Adiadochokineses, Adiadochokinesis, Ataxia Cerebellar, Ataxias Cerebellar, Cerebellar Ataxias, Cerebellar Dysmetria, Cerebellar Dysmetrias, CEREBELLAR HEMIATAXIA, Cerebellar Hemiataxias, CEREBELLAR INCOORDINATION, Cerebellar Incoordinations
Documents 78
Hot Single Events 36
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Cerebellar Ataxia. They are ordered first by their relevance to Cerebellar Ataxia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT199667 Cep290 Regulation of Atf4 1 0.04 1.96 0.09 92.96
2 INT199666 Cntln Regulation of Atf4 1 0.00 1.95 0.09 92.96
3 INT219154 Binding of HMGB1 and TLR4 2 0.17 4.45 0.93 5.00
4 INT309513 Binding of Xrcc6 and Htt 1 0.30 3.69 0.21 5.00
5 INT336946 Binding of ITGA4 and VCAM1 1 0.03 2.02 0.21 5.00
6 INT302712 Binding of Hprt and Hrh1 1 0.25 1.07 0.2 5.00
7 INT302711 Binding of Hrh1 and Spnb4 1 0.18 1.07 0.2 5.00
8 INT309511 Binding of Xrcc6 and Xrcc5 1 0.18 1.18 0.08 5.00
9 INT251944 Binding of GH1 and PRNP 1 0.09 1.14 0.05 5.00
10 INT235168 Binding of Crx and Atxn7 1 0.11 0.81 0.03 5.00
11 INT199665 Binding of Fxn and Lamtor3 1 0.00 0.16 0.03 5.00
12 INT309515 Xrcc6 Regulation of Gene_expression of Htt 1 0.32 0.08 0 5.00
13 INT239406 Binding of MTTP and TAOK1 1 0.02 0.51 0 5.00
14 INT309521 PRKDC Regulation of Gene_expression of Htt 1 0.41 0.08 0 5.00
15 INT309517 Binding of Bax and Xrcc6 1 0.15 0.5 0 5.00
16 INT235165 Atxn3 Regulation of Transcription of Crebbp 1 0.02 0.3 0 5.00
17 INT309519 Xrcc5 Regulation of Gene_expression of Htt 1 0.18 0.08 0 5.00
18 INT239407 Binding of MTTP and PADI1 1 0.23 0.5 0 5.00
19 INT309512 Negative_regulation of Xrcc6 Positive_regulation of Phosphorylation of Gopc 1 0.20 0.17 0 5.00
20 INT235166 Binding of Hdac3 and Atxn1 1 0.02 0.28 0 5.00
21 INT345060 Binding of SGCG and C2 1 0.00 0.93 0 5.00
22 INT239408 Binding of PADI1 and TAOK1 1 0.01 0.51 0 5.00
23 INT235167 Binding of Hdac3 and Ncor2 1 0.01 0.28 0 5.00
24 INT309518 Negative_regulation of Binding of Bax and Xrcc6 1 0.16 0.25 0 5.00
25 INT345059 Binding of C3 and C2 1 0.00 0 0 5.00
26 INT235164 Binding of Atxn1 and Ncor2 1 0.15 0.42 0 5.00
27 INT309520 Htt Negative_regulation of Binding of Xrcc6 and Xrcc5 1 0.15 0.47 0 5.00
28 INT309516 Htt Positive_regulation of Gene_expression of Xrcc6 1 0.49 0.06 0 5.00
29 INT309509 Negative_regulation of Binding of Xrcc6 and Htt 1 0.31 0.41 0 5.00
30 INT309510 Htt Regulation of Gene_expression of Xrcc6 1 0.19 0.15 0 5.00
31 INT309508 Htt Negative_regulation of Binding of Xrcc6 1 0.31 0.48 0 5.00
32 INT235169 Gene_expression of Dnaja1 Negative_regulation of Binding of Atxn1 1 0.09 0.47 0 5.00
33 INT309514 Positive_regulation of Binding of Xrcc6 and Htt 1 0.33 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Cerebellar Ataxia. They are ordered first by their pain relevance and then by number of times they were reported in Cerebellar Ataxia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT3405 Gene_expression of BCAR1 14 0.71 8.89 4.02 100.00
2 INT85572 Gene_expression of Cacna1a 11 0.66 5.72 3.02 100.00
3 INT3404 Binding of BCAR1 10 0.33 7.97 1.33 100.00
4 INT3403 Positive_regulation of BCAR1 18 0.63 18.95 3.23 100.00
5 INT82177 Negative_regulation of H2-Q10 5 0.58 5.83 0.45 99.76
6 INT94563 Gene_expression of H2-Q10 7 0.42 7 0.88 99.76
7 INT199644 Positive_regulation of Gene_expression of H2-Q10 3 0.37 2.6 0.15 99.76
8 INT205596 Negative_regulation of COQ10A 22 0.51 15.61 2.77 99.74
9 INT69435 Negative_regulation of ROS1 74 0.51 50.38 13.71 98.52
10 INT309506 Positive_regulation of Tdp1 1 0.23 1.19 0 98.44
11 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 98.28
12 INT10100 Binding of ELANE 22 0.47 15.32 5.19 95.64
13 INT105021 Binding of GOPC 187 0.40 60.39 20.38 95.44
14 INT57232 Binding of Casp3 22 0.36 9.42 6.2 94.80
15 INT205594 Gene_expression of COQ10A 19 0.67 12.53 2.56 93.56
16 INT167203 Binding of PRNP 25 0.48 20.09 1.84 93.24
17 INT309244 Transcription of HSPA5 1 0.16 2.75 0.36 92.80
18 INT649 Positive_regulation of Afp 10 0.55 6.5 0.62 92.52
19 INT309255 Gene_expression of NDUFV1 1 0.01 2.33 0 90.96
20 INT199640 Positive_regulation of Positive_regulation of Fxn 2 0.41 2.97 0.14 90.76
21 INT199642 Positive_regulation of Fxn 3 0.41 3.6 0.14 90.48
22 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58 90.40
23 INT4498 Gene_expression of F2 83 0.65 57.4 10.8 88.96
24 INT189813 Negative_regulation of CACNA1A 4 0.57 3.07 0.55 85.16
25 INT5653 Positive_regulation of ELANE 136 0.70 72.78 27.94 85.00
26 INT25674 Positive_regulation of Gene_expression of ELANE 16 0.60 7.46 3.12 85.00
27 INT8580 Gene_expression of ELANE 132 0.75 62.98 21.79 84.60
28 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9 83.32
29 INT194794 Binding of TTPA 7 0.08 2.56 0.57 81.32
30 INT235132 Gene_expression of Ppp2r2b 1 0.55 2.31 0.11 80.80
31 INT66331 Gene_expression of Cacna1a 101 0.78 49.58 46.32 80.80
32 INT181809 Gene_expression of Atxn1 81 0.77 28.66 1.42 80.80
33 INT235157 Gene_expression of Atxn2 3 0.68 6.74 1.23 80.80
34 INT55315 Gene_expression of Tbp 32 0.74 14.6 1.17 80.80
35 INT135045 Gene_expression of Atxn3 34 0.78 11.59 0.36 80.80
36 INT235160 Gene_expression of Atxn7 1 0.56 2 0.04 80.80
37 INT144380 Gene_expression of SYNE1 12 0.58 6.99 1.55 79.64
38 INT309248 Negative_regulation of ATXN8OS 1 0.06 1.49 0 79.12
39 INT189811 Negative_regulation of ATXN3 1 0.35 3.09 0 78.52
40 INT199661 Negative_regulation of TTPA 2 0.04 1.84 0 78.48
41 INT27493 Negative_regulation of Casp3 114 0.56 56.89 44.63 78.16
42 INT189809 Negative_regulation of HEXA 1 0.57 3.93 0 77.88
43 INT164193 Localization of ATN1 2 0.73 1.47 0.03 75.92
44 INT199647 Regulation of Phyh 1 0.27 2.71 0 75.44
45 INT309258 Localization of TBP 2 0.27 1.78 0.03 75.04
46 INT309256 Localization of ATXN7 1 0.11 1.46 0.03 74.48
47 INT161575 Localization of CACNA1A 4 0.75 5.28 2.26 74.00
48 INT309250 Localization of ATXN3 1 0.14 1.46 0.03 73.52
49 INT309246 Localization of ATXN2 1 0.10 1.45 0.03 73.04
50 INT79425 Gene_expression of SMN1 42 0.65 36.37 6.1 72.84
51 INT309254 Localization of ATXN1 1 0.09 1.45 0.03 72.56
52 INT87314 Gene_expression of Htt 112 0.78 55.82 3.03 69.60
53 INT115300 Negative_regulation of Napa 7 0.23 1 2.68 69.32
54 INT235138 Gene_expression of Atxn8os 2 0.76 6.89 1.05 69.28
55 INT59466 Gene_expression of ISYNA1 204 0.77 112.57 35.48 69.04
56 INT235151 Gene_expression of Atxn10 1 0.34 0.73 0 69.04
57 INT309481 Binding of Rbm17 1 0.18 0.82 0 66.84
58 INT49209 Positive_regulation of GAD1 17 0.70 15.39 5.59 66.68
59 INT19430 Positive_regulation of IGHA1 10 0.67 6.42 2.58 66.68
60 INT46273 Gene_expression of PRNP 103 0.78 110.34 9.25 64.72
61 INT53184 Negative_regulation of CYP27A1 46 0.57 16.04 5.28 64.64
62 INT309465 Gene_expression of Xrcc6 24 0.59 5.49 0.43 63.60
63 INT9292 Positive_regulation of SGCG 93 0.67 35.13 23.48 62.84
64 INT187422 Negative_regulation of MTTP 23 0.57 11.75 0.24 62.68
65 INT199650 Negative_regulation of Phyh 1 0.42 2.2 0.04 62.28
66 INT309245 Binding of SETX 1 0.08 1.98 0.06 61.92
67 INT65697 Positive_regulation of GRIN3B 23 0.69 12.52 13.78 58.92
68 INT76092 Localization of ISYNA1 10 0.66 7.72 3.11 58.32
69 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 57.76
70 INT131674 Negative_regulation of HEXB 3 0.10 3.78 0.32 56.56
71 INT199656 Binding of Pnkp 1 0.07 1.36 0.07 56.24
72 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 54.96
73 INT115615 Regulation of SCA25 1 0.36 0.56 0.07 49.64
74 INT74389 Gene_expression of Gdnf 131 0.78 58.52 57.06 47.64
75 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 46.04
76 INT199649 Gene_expression of Fxn 12 0.72 20.9 0.74 43.76
77 INT192856 Regulation of Gene_expression of Ppp2r1a 2 0.16 0.62 0.12 42.12
78 INT235150 Regulation of Gene_expression of Ppp2r2b 1 0.32 0.48 0.11 42.12
79 INT181801 Regulation of Atxn1 3 0.29 1.08 0 41.76
80 INT192857 Gene_expression of Ppp2r1a 6 0.47 1.74 0.19 41.68
81 INT31874 Negative_regulation of Gene_expression of Abat 31 0.42 12.22 20.31 38.00
82 INT9987 Gene_expression of Abat 296 0.78 95.46 226.34 37.44
83 INT309251 Gene_expression of OGDHL 1 0.01 0.64 0.29 36.56
84 INT31136 Binding of Cacna1a 28 0.45 30.76 17.35 36.08
85 INT102112 Gene_expression of Prnp 440 0.78 209.32 22.5 35.80
86 INT309502 Positive_regulation of Xrcc6 1 0.38 1.58 0 34.72
87 INT11198 Negative_regulation of Gclc 3 0.59 0.49 0.87 34.64
88 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 34.16
89 INT239412 Binding of ABL1 8 0.28 5.39 0.18 30.92
90 INT309249 Regulation of OGDHL 1 0.01 0.6 0.3 28.72
91 INT69569 Positive_regulation of Prnp 175 0.70 96.31 13.34 27.36
92 INT69572 Localization of Prnp 96 0.81 38.11 5.45 27.36
93 INT50687 Gene_expression of Aldoc 6 0.78 0.17 0.78 25.24
94 INT96952 Gene_expression of Gclc 7 0.38 2.08 0.28 25.04
95 INT261026 Localization of Gclc 3 0.36 0.88 0.06 25.04
96 INT28673 Gene_expression of APOB 51 0.73 34.02 3.95 24.88
97 INT87517 Gene_expression of LDLR 73 0.69 37.35 3.32 24.88
98 INT117662 Gene_expression of ABL1 21 0.69 18.76 0.39 24.88
99 INT309486 Positive_regulation of Chek1 1 0.22 0.6 0 22.96
100 INT261017 Regulation of Gclc 2 0.22 0.88 0.06 22.08
101 INT185246 Gene_expression of Psmd1 26 0.50 8.89 3.73 20.80
102 INT69570 Binding of Prnp 75 0.48 44.26 4.37 17.16
103 INT109972 Phosphorylation of Trp53 13 0.80 6.15 4.68 15.80
104 INT207806 Phosphorylation of Atm 8 0.81 3.07 0.06 15.80
105 INT309503 Phosphorylation of Xrcc6 1 0.54 0.55 0 15.80
106 INT197121 Positive_regulation of Atm 24 0.69 6.81 0.25 14.52
107 INT109594 Positive_regulation of ABL1 10 0.49 7.19 0.05 13.44
108 INT199641 Regulation of Transcription of Fxn 1 0.29 1.89 0.04 12.28
109 INT199648 Regulation of Fxn 1 0.29 2.14 0.04 12.28
110 INT199646 Transcription of Fxn 2 0.67 4.78 0.08 11.60
111 INT93359 Positive_regulation of Trp53 90 0.70 69.77 6.24 10.80
112 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
113 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
114 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
115 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
116 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94 5.00
117 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
118 INT2211 Negative_regulation of Abat 267 0.59 66.51 200.98 5.00
119 INT49441 Negative_regulation of Cpox 494 0.59 303.22 177.46 5.00
120 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
121 INT2910 Regulation of Abat 169 0.62 36.95 153.53 5.00
122 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
123 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
124 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03 5.00
125 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
126 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 5.00
127 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
128 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 5.00
129 INT647 Gene_expression of SGCG 211 0.75 78.46 55.82 5.00
130 INT42980 Gene_expression of GAD1 139 0.69 94.77 45.11 5.00
131 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 5.00
132 INT114751 Gene_expression of Mapk1 137 0.76 60.14 39.98 5.00
133 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67 5.00
134 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 5.00
135 INT10763 Localization of IL2 157 0.80 81.11 33.21 5.00
136 INT6302 Binding of IFNA1 196 0.48 133.85 32.73 5.00
137 INT62830 Gene_expression of VCAM1 149 0.78 125.23 32.4 5.00
138 INT719 Negative_regulation of SGCG 96 0.57 47.91 30.22 5.00
139 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 5.00
140 INT58192 Positive_regulation of MRI1 86 0.61 53.81 24.68 5.00
141 INT55583 Localization of IFNA1 135 0.78 85.07 24.13 5.00
142 INT35716 Positive_regulation of NCOR2 45 0.60 18 23.54 5.00
143 INT134651 Binding of TLR4 89 0.48 66.96 23.19 5.00
144 INT16996 Gene_expression of PRTN3 113 0.75 85.61 22.57 5.00
145 INT14700 Regulation of IFNA1 111 0.45 66.16 21.52 5.00
146 INT955 Gene_expression of GHRH 126 0.78 59.91 20.74 5.00
147 INT24225 Gene_expression of Alms1 93 0.62 52.75 16.93 5.00
148 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65 5.00
149 INT71634 Gene_expression of SLC6A3 45 0.78 13.48 15.23 5.00
150 INT70265 Regulation of MRI1 42 0.39 30.95 14.18 5.00
151 INT5207 Negative_regulation of Alms1 70 0.41 41.56 13.68 5.00
152 INT6478 Negative_regulation of Binding of TNF 36 0.58 30.42 13.31 5.00
153 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 5.00
154 INT49975 Binding of SLC6A3 34 0.47 9.86 12.41 5.00
155 INT14510 Gene_expression of SOD1 208 0.76 88.56 12.4 5.00
156 INT73829 Positive_regulation of Gene_expression of VCAM1 41 0.61 35.96 11.92 5.00
157 INT1735 Gene_expression of HSD11B1 199 0.75 257.87 11.5 5.00
158 INT67048 Gene_expression of ITGA4 58 0.75 28.93 10.16 5.00
159 INT178306 Negative_regulation of Gene_expression of Gopc 71 0.37 26.43 9.74 5.00
160 INT123701 Negative_regulation of VDR 61 0.59 48.94 9.67 5.00
161 INT1118 Gene_expression of C6orf25 73 0.77 47.24 9.1 5.00
162 INT95414 Positive_regulation of Alms1 40 0.41 20.3 8.1 5.00
163 INT175526 Phosphorylation of Gopc 73 0.53 21.08 7.86 5.00
164 INT18524 Regulation of Gene_expression of IFNA1 37 0.44 18.79 7.62 5.00
165 INT96619 Negative_regulation of CSAD 7 0.36 8.96 7.47 5.00
166 INT157959 Binding of AQP4 32 0.48 43.44 7.44 5.00
167 INT10478 Protein_catabolism of Alms1 25 0.47 12.95 7.19 5.00
168 INT55957 Positive_regulation of PRNP 57 0.67 37.87 7.11 5.00
169 INT5864 Localization of IL36RN 19 0.44 14.5 6.87 5.00
170 INT11957 Negative_regulation of LPA 52 0.59 39.09 6.84 5.00
171 INT49212 Negative_regulation of GAD1 23 0.59 22.15 6.54 5.00
172 INT14238 Positive_regulation of Cd69 19 0.60 17.75 6.07 5.00
173 INT20200 Positive_regulation of Serpinc1 25 0.68 17.08 4.98 5.00
174 INT98613 Gene_expression of CSAD 7 0.53 7.86 4.8 5.00
175 INT51030 Negative_regulation of LMOD1 9 0.44 5.83 4.58 5.00
176 INT36309 Negative_regulation of DIO2 18 0.57 6.42 4.51 5.00
177 INT98357 Binding of Gnas 11 0.41 1.87 4.35 5.00
178 INT184288 Localization of HMGB1 20 0.61 14.5 3.84 5.00
179 INT148085 Binding of CXCL10 14 0.32 10.22 3.81 5.00
180 INT54848 Protein_catabolism of SGCG 12 0.96 3.8 3.78 5.00
181 INT78284 Positive_regulation of PTPRC 40 0.49 27.17 3.45 5.00
182 INT1727 Gene_expression of Cndp2 22 0.74 4.28 3.34 5.00
183 INT195982 Gene_expression of Atp1a2 5 0.65 1.54 3.19 5.00
184 INT550 Negative_regulation of LDLR 66 0.43 44.71 3.04 5.00
185 INT45971 Negative_regulation of GOT1 9 0.51 6.2 2.84 5.00
186 INT50080 Binding of APOE 38 0.45 29.61 2.67 5.00
187 INT18848 Localization of LMOD1 5 0.69 1 2.49 5.00
188 INT56658 Gene_expression of Spnb4 7 0.58 5.6 2.22 5.00
189 INT19804 Negative_regulation of Hprt 18 0.59 20.6 2.17 5.00
190 INT90272 Gene_expression of Ppp2ca 18 0.68 4.69 2.08 5.00
191 INT154651 Negative_regulation of Nfe2l2 19 0.59 10.48 2.01 5.00
192 INT96764 Positive_regulation of Gene_expression of SOD1 36 0.61 16.55 1.99 5.00
193 INT173512 Positive_regulation of Gene_expression of Alms1 12 0.44 8.66 1.95 5.00
194 INT56656 Positive_regulation of Spnb4 3 0.49 1.09 1.92 5.00
195 INT80221 Regulation of Eno2 4 0.35 4.64 1.89 5.00
196 INT40877 Positive_regulation of APOB 35 0.68 32.47 1.86 5.00
197 INT122895 Transcription of DIO2 3 0.52 0.91 1.73 5.00
198 INT97062 Binding of PML 10 0.41 11.63 1.65 5.00
199 INT22785 Negative_regulation of PRNP 12 0.57 5.09 1.57 5.00
200 INT309257 Transcription of LMOD1 3 0.36 1.71 1.57 5.00
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox