D:Cerebral Aneurysm

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Disease Term
Synonyms Aneurysm Anterior Cerebral Artery, Aneurysm Anterior Communicating Artery, Aneurysm Basilar Artery, Aneurysm Berry, Aneurysm Brain, Aneurysm Cerebral, Aneurysm Giant Intracranial, Aneurysm Intracranial, ANEURYSM INTRACRANIAL MYCOTIC, Aneurysm Middle Cerebral Artery, ANEURYSM POSTERIOR CEREBRAL ARTERY
Documents 950
Hot Single Events 67
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Cerebral Aneurysm. They are ordered first by their relevance to Cerebral Aneurysm and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT278223 Binding of NOS3 and ACSM3 1 0.41 6.32 1.65 100.00
2 INT278224 Binding of ACSM3 and SNRNP70 1 0.04 3.76 1.01 100.00
3 INT170157 NPPC Regulation of CSF2 1 0.12 1.36 0.42 54.80
4 INT278227 Binding of MBNL1 and SNRNP70 1 0.01 2.05 0.54 5.00
5 INT278228 Binding of MBNL1 and NOS3 1 0.05 2.06 0.54 5.00
6 INT278225 Binding of FOSB and SNRNP70 1 0.00 1.22 0.36 5.00
7 INT278226 Binding of FOSB and NOS3 1 0.03 1.22 0.36 5.00
8 INT170158 NPPA Positive_regulation of Gene_expression of NPPB 1 0.13 0.91 0.23 5.00
9 INT250553 Binding of RS1 and SUGT1 3 0.00 3.36 0.22 5.00
10 INT354544 Avp Positive_regulation of ADCY1 1 0.24 2.23 0.22 5.00
11 INT274080 Binding of ARHGAP4 and Map3k5 1 0.41 1.92 0.2 5.00
12 INT126944 Binding of PKD2 and Pkd1 2 0.08 2.09 0.19 5.00
13 INT170159 Negative_regulation of NPPC Regulation of CSF2 1 0.20 0.33 0.11 5.00
14 INT274078 Binding of Mapk8 and Gmcl1 1 0.05 0.68 0.04 5.00
15 INT310202 Binding of RS1 and SNRNP70 1 0.05 1.77 0 5.00
16 INT274076 Binding of Map3k5 and Gmcl1 1 0.06 1.23 0 5.00
17 INT274077 Binding of Tnfrsf1b and Positive_regulation of Mapk8 1 0.14 0.97 0 5.00
18 INT289626 Binding of SNRNP70 and SUGT1 3 0.03 2.49 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Cerebral Aneurysm. They are ordered first by their pain relevance and then by number of times they were reported in Cerebral Aneurysm. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT171686 Binding of asp1 8 0.31 11.88 1.07 100.00
2 INT22513 Gene_expression of asp1 8 0.58 4.36 1.26 100.00
3 INT15502 Regulation of asp1 6 0.19 2.29 1.2 100.00
4 INT208142 Gene_expression of PITX1 3 0.65 9.36 0.73 100.00
5 INT15470 Regulation of CPP 42 0.48 26.1 18.25 99.96
6 INT39948 Binding of FLNA 45 0.42 58.05 4.27 99.76
7 INT25402 Binding of Ptcra 10 0.34 3.54 1.85 99.76
8 INT14916 Binding of RASA1 15 0.37 13.64 1.44 99.74
9 INT116001 Binding of FND 3 0.06 3.69 0.1 99.56
10 INT2140 Regulation of REN 104 0.62 28.24 24.49 99.40
11 INT8960 Binding of SDHB 9 0.36 9.2 1.68 99.28
12 INT654 Localization of REN 250 0.81 75.12 47.86 98.70
13 INT86947 Gene_expression of Arigg3 6 0.58 3.62 0.57 98.08
14 INT242267 Localization of Slc25a16 1 0.34 6.15 0.43 98.00
15 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 97.88
16 INT10721 Gene_expression of BDNF-AS 119 0.76 72.8 16.29 97.68
17 INT3593 Gene_expression of ADRA1D 70 0.75 29.48 20.87 97.40
18 INT5780 Regulation of Gene_expression of Calca 90 0.62 59.52 85.03 97.36
19 INT137850 Gene_expression of PKD2 9 0.65 6.68 0.63 97.12
20 INT129174 Gene_expression of PKD1 24 0.67 14.91 0.74 97.12
21 INT175898 Positive_regulation of PKD1 1 0.50 1.24 0 97.12
22 INT80118 Gene_expression of NPPC 2 0.68 4.14 0.77 96.76
23 INT242268 Binding of Slc25a16 1 0.17 1.67 0.15 96.52
24 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 96.24
25 INT39693 Regulation of ZNF83 1 0.12 0.4 0.09 96.20
26 INT104756 Gene_expression of ACSM3 8 0.58 8.76 1.83 96.04
27 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 96.04
28 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 96.04
29 INT39694 Regulation of LIPC 2 0.58 0.89 0.14 96.00
30 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 94.72
31 INT152404 Regulation of PKD1 2 0.45 2.02 1.04 94.40
32 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 93.84
33 INT175900 Regulation of ENPP1 1 0.00 1.96 0.16 93.76
34 INT1116 Regulation of Ren 103 0.62 27.66 33.26 93.76
35 INT653 Negative_regulation of Localization of REN 67 0.59 20.33 16.7 93.72
36 INT17024 Gene_expression of COL1A2 69 0.77 36.38 8.29 93.56
37 INT2867 Gene_expression of CALCA 247 0.78 78.78 138.47 93.56
38 INT217070 Gene_expression of Acsm3 8 0.25 6.27 1.75 93.44
39 INT237217 Gene_expression of Plekhb1 1 0.02 1.11 0.04 93.20
40 INT46 Localization of Ren 233 0.81 46.15 62.44 92.68
41 INT481 Regulation of Localization of Ren 37 0.62 5.95 11.61 92.68
42 INT43900 Gene_expression of RASA1 13 0.58 12 2.03 92.48
43 INT11553 Negative_regulation of CCBE1 3 0.03 1.1 1.25 92.20
44 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 92.16
45 INT11919 Regulation of KRT1 9 0.10 4.97 0.77 91.56
46 INT2541 Binding of Calca 200 0.48 67.14 134.62 91.56
47 INT63121 Binding of APC 29 0.41 23.02 3.8 90.76
48 INT314 Positive_regulation of Ren 212 0.70 66.68 55.56 88.32
49 INT113948 Gene_expression of FLNA 32 0.73 36.06 4.81 88.08
50 INT660 Negative_regulation of REN 194 0.59 82.06 29.46 87.80
51 INT335202 Negative_regulation of 119L04aR 1 0.01 0.38 0 87.24
52 INT14960 Positive_regulation of Serpinc1 17 0.68 12.71 3.02 87.16
53 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 86.56
54 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 84.80
55 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 84.80
56 INT129534 Gene_expression of Nppb 19 0.58 23.68 1.6 84.80
57 INT2339 Positive_regulation of CB 30 0.29 10.68 9.12 84.64
58 INT175896 Transcription of PKD1 1 0.53 1.22 0 84.44
59 INT169180 Binding of SNRNP70 204 0.47 119.1 29.3 84.00
60 INT146300 Binding of RS1 31 0.22 29.55 3.04 83.80
61 INT5841 Gene_expression of Vim 181 0.72 138.54 16.33 83.04
62 INT4993 Gene_expression of Lrrc23 13 0.66 11.04 1.99 83.04
63 INT149018 Binding of Macc1 1 0.05 1.02 0.24 82.12
64 INT33039 Regulation of Ptcra 3 0.04 1.16 0.37 81.96
65 INT286543 Localization of Pkd1 5 0.52 3.74 0.04 80.72
66 INT85623 Gene_expression of ATXN1 6 0.58 5.14 0.9 80.48
67 INT3533 Binding of REN 24 0.37 10.84 2.16 80.32
68 INT83201 Gene_expression of NOS3 93 0.78 47.16 12.48 79.20
69 INT2540 Negative_regulation of Calca 538 0.59 172.11 384.38 77.68
70 INT139738 Gene_expression of Ptcra 9 0.63 2.75 1.14 77.60
71 INT9199 Positive_regulation of CEBPZ 111 0.67 30.99 28.45 77.44
72 INT2393 Positive_regulation of Mb 174 0.69 93.59 26.79 77.40
73 INT16478 Positive_regulation of Plg 29 0.45 18.07 4.07 76.80
74 INT311687 Binding of 119L04aR 2 0.01 0.61 0 75.88
75 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 75.60
76 INT53020 Positive_regulation of ACSM3 9 0.58 11.03 2.73 75.00
77 INT23954 Negative_regulation of Mb 24 0.49 11.27 2.55 75.00
78 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 75.00
79 INT655 Positive_regulation of Localization of REN 86 0.70 32.41 13.56 75.00
80 INT3244 Negative_regulation of eCB 37 0.03 16.69 12.61 75.00
81 INT28872 Positive_regulation of CSRP1 49 0.70 47.23 11.7 75.00
82 INT1118 Gene_expression of C6orf25 73 0.77 47.24 9.1 75.00
83 INT58563 Negative_regulation of S100B 13 0.51 11.75 1.77 75.00
84 INT161706 Negative_regulation of Gene_expression of S100B 8 0.43 2.69 1.06 75.00
85 INT11071 Positive_regulation of PPBP 43 0.68 26.85 13.43 73.04
86 INT10969 Positive_regulation of PLEK 33 0.67 16.96 8.35 73.04
87 INT49 Negative_regulation of Ren 129 0.59 37.48 35.62 71.12
88 INT212536 Negative_regulation of COL3A1 2 0.57 3.53 0.21 70.48
89 INT56374 Gene_expression of AMBP 34 0.54 35.85 6.25 68.80
90 INT47030 Negative_regulation of ARMC9 22 0.38 13.08 0.47 67.20
91 INT56375 Positive_regulation of AMBP 25 0.60 21.24 2.22 65.64
92 INT16631 Negative_regulation of APC 46 0.57 30.53 7.11 63.44
93 INT50 Negative_regulation of Localization of Ren 87 0.59 14.94 30.22 62.44
94 INT165813 Gene_expression of CES1 31 0.76 6.08 0.66 62.12
95 INT8490 Negative_regulation of CALCA 87 0.59 29.73 51.34 62.00
96 INT48 Positive_regulation of Localization of Ren 69 0.70 12.47 18.03 61.44
97 INT93350 Binding of Lepr 17 0.05 27.21 1.5 60.16
98 INT2482 Regulation of Positive_regulation of REN 4 0.59 2.62 0.91 58.68
99 INT105021 Binding of GOPC 187 0.40 60.39 20.38 58.40
100 INT170163 Negative_regulation of ACSM3 5 0.16 3.56 0.96 55.72
101 INT39692 Positive_regulation of CYTIP 2 0.24 0.56 0.06 54.64
102 INT164595 Binding of LCN2 8 0.37 6.03 0.6 54.40
103 INT289631 Localization of RS1 4 0.21 3.17 0.42 54.00
104 INT85952 Positive_regulation of AR 168 0.67 64.36 20.66 50.00
105 INT15762 Negative_regulation of asp1 6 0.37 0.71 0.4 50.00
106 INT203283 Binding of KDM5D 3 0.11 1.22 0.21 50.00
107 INT244102 Phosphorylation of ACSM3 1 0.31 0.73 0.12 50.00
108 INT244103 Localization of DOCK3 1 0.32 0.26 0 50.00
109 INT29745 Binding of APP 47 0.48 26.49 12.4 48.48
110 INT39695 Negative_regulation of ZNF83 1 0.18 0.57 0 47.32
111 INT65698 Localization of CCL2 118 0.81 77.54 32.69 47.16
112 INT110767 Localization of Mcpt1 43 0.68 24.3 16.74 47.16
113 INT2108 Localization of Mif 5 0.77 2.7 0.73 47.16
114 INT311689 Positive_regulation of 119L04aR 2 0.01 1.09 0.1 46.32
115 INT11685 Regulation of CSF2 99 0.59 58.82 15.9 45.24
116 INT92814 Negative_regulation of NOS3 25 0.51 20.67 3.07 38.72
117 INT272228 Localization of TGFBR1 1 0.34 0.74 0 38.08
118 INT272225 Localization of Tgfbr2 1 0.29 0.74 0 38.08
119 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91 34.16
120 INT146758 Gene_expression of LCN2 45 0.78 38.29 2.97 34.08
121 INT1533 Negative_regulation of AGT 105 0.42 46.54 16.92 33.24
122 INT58192 Positive_regulation of MRI1 86 0.61 53.81 24.68 30.40
123 INT9784 Binding of B2M 9 0.47 6.18 1.44 29.44
124 INT132459 Binding of FABP3 4 0.35 2.19 0.2 29.12
125 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 25.00
126 INT46646 Localization of FLNA 19 0.73 18.83 2.53 25.00
127 INT354534 Binding of Havcr1 1 0.03 0.81 0.08 24.72
128 INT224722 Binding of Mcpt1 6 0.10 4.82 1.03 24.04
129 INT134753 Gene_expression of TIMP3 19 0.68 15.24 0.88 23.44
130 INT274268 Localization of OPA2 1 0.12 1.48 0 17.84
131 INT57057 Gene_expression of APC 131 0.78 122.24 8.7 13.44
132 INT146994 Regulation of NPPC 2 0.22 1.46 0.37 6.00
133 INT21569 Binding of Mapk8 8 0.48 5.55 3.44 5.44
134 INT274069 Binding of Map3k5 1 0.29 2.68 0.49 5.44
135 INT274074 Binding of Map2k4 1 0.08 1.98 0.36 5.44
136 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
137 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
138 INT1033 Positive_regulation of Ca2 507 0.68 131.76 147.64 5.00
139 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
140 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
141 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.00
142 INT1080 Negative_regulation of Ache 343 0.59 108.51 72.4 5.00
143 INT171145 Positive_regulation of Fig4 274 0.59 93.55 69.81 5.00
144 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
145 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 5.00
146 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9 5.00
147 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 5.00
148 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
149 INT117713 Phosphorylation of Akt1 275 0.82 95.82 54.34 5.00
150 INT40777 Positive_regulation of Akt1 163 0.69 59.41 49.43 5.00
151 INT22454 Regulation of Crp 213 0.62 160.67 49.24 5.00
152 INT170646 Negative_regulation of Fig4 213 0.37 81.29 46.92 5.00
153 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 5.00
154 INT2774 Binding of Crp 241 0.48 195.89 44.39 5.00
155 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 5.00
156 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61 5.00
157 INT84260 Positive_regulation of Mapk8 124 0.69 72.84 35.98 5.00
158 INT59466 Gene_expression of ISYNA1 204 0.77 112.57 35.48 5.00
159 INT3679 Gene_expression of AVP 171 0.78 72.9 35.23 5.00
160 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 5.00
161 INT95734 Phosphorylation of Mapk8 108 0.82 49.92 33.52 5.00
162 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7 5.00
163 INT2532 Negative_regulation of Cebpz 98 0.00 53.06 28.57 5.00
164 INT177581 Regulation of Fig4 113 0.41 39.26 27.75 5.00
165 INT37296 Binding of Esr1 117 0.43 62.51 27.33 5.00
166 INT14690 Localization of CSF2 124 0.80 85.17 27.26 5.00
167 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 5.00
168 INT76095 Positive_regulation of ISYNA1 117 0.55 79.73 25.86 5.00
169 INT151758 Gene_expression of PYCARD 91 0.63 14.54 24.27 5.00
170 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73 5.00
171 INT23257 Regulation of CRP 127 0.62 100.05 21.87 5.00
172 INT99068 Gene_expression of Mapk8 62 0.78 33.57 21.25 5.00
173 INT69304 Negative_regulation of Il10 47 0.59 36.88 19.79 5.00
174 INT65211 Binding of Prkcg 38 0.48 14.75 16.92 5.00
175 INT3002 Binding of SUGT1 62 0.24 55.9 14.91 5.00
176 INT70265 Regulation of MRI1 42 0.39 30.95 14.18 5.00
177 INT18773 Localization of ALB 117 0.80 69.18 13.8 5.00
178 INT10870 Regulation of IgG 67 0.59 43.27 12.74 5.00
179 INT11121 Positive_regulation of NPPA 64 0.70 34.09 11.96 5.00
180 INT32007 Gene_expression of ECT 56 0.62 18.94 11.13 5.00
181 INT23094 Positive_regulation of Positive_regulation of Ca2 29 0.49 6.8 9.35 5.00
182 INT120967 Negative_regulation of Phosphorylation of Akt1 47 0.57 23.67 8.98 5.00
183 INT131788 Positive_regulation of NPPB 87 0.67 86.1 8.81 5.00
184 INT10879 Positive_regulation of Avp 39 0.65 14.01 8.76 5.00
185 INT8637 Negative_regulation of Dbp 112 0.50 33.28 8.4 5.00
186 INT725 Negative_regulation of IgG 62 0.41 37.21 8.16 5.00
187 INT99071 Positive_regulation of Gene_expression of Mapk8 16 0.55 9.87 7.58 5.00
188 INT11823 Positive_regulation of GGT1 53 0.67 45.84 7.55 5.00
189 INT32709 Negative_regulation of Hbb 30 0.54 18.27 6.97 5.00
190 INT62950 Gene_expression of NPPB 73 0.75 65.91 6.54 5.00
191 INT17262 Negative_regulation of Plat 17 0.59 15.14 6.36 5.00
192 INT16359 Positive_regulation of Gene_expression of AGT 30 0.49 28.27 6.14 5.00
193 INT27408 Phosphorylation of POMC 9 0.80 2.18 5.88 5.00
194 INT29368 Binding of ECT 25 0.41 11.65 5.81 5.00
195 INT56149 Localization of CD8A 56 0.74 30.41 5.75 5.00
196 INT21103 Gene_expression of Dbp 48 0.61 22.6 5.59 5.00
197 INT43997 Positive_regulation of Gene_expression of Esr1 57 0.51 36.66 5.51 5.00
198 INT63957 Positive_regulation of Tnnt2 33 0.69 18.56 5.41 5.00
199 INT18543 Negative_regulation of ECT 20 0.37 8.4 5.25 5.00
200 INT24080 Negative_regulation of Mtor 64 0.37 41.56 5.19 5.00
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