D:Ceroid Lipofuscinosis

From wiki-pain
Jump to: navigation, search

pChart

Disease Term
Synonyms Adult Neuronal Ceroid Lipfuscinosis, Batten Disease, Batten Diseases, Batten Mayou Disease, BATTEN MAYOU DISEASES, Batten Spielmeyer Vogt Disease, CEREBROMACULAR DEGENERATION, Cerebromacular Dystrophy, Cerebroretinal Degeneration Disease, Cerebroretinal Degeneration Juvenile, Cerebroretinal Degenerations Juvenile
Documents 19
Hot Single Events 13
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Ceroid Lipofuscinosis. They are ordered first by their relevance to Ceroid Lipofuscinosis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT317900 Binding of NCAPH2 and MCPH1 1 0.02 0.53 0 9.80
2 INT180246 Binding of Tbca and Uchl1 1 0.00 0.47 0.27 5.00
3 INT180245 Binding of Plp1 and Uchl1 1 0.03 0.47 0.27 5.00
4 INT180247 Binding of Gad1 and Tbca 1 0.02 0.22 0.22 5.00
5 INT180248 Binding of Gad1 and Plp1 1 0.08 0.22 0.21 5.00
6 INT180252 Negative_regulation of Gad1 Positive_regulation of CP 1 0.03 0.75 0.14 5.00
7 INT243233 Positive_regulation of Ighmbp2 Negative_regulation of Rs1 1 0.11 0.31 0 5.00
8 INT243235 Ighmbp2 Negative_regulation of Rs1 1 0.11 0.31 0 5.00
9 INT243232 Ighmbp2 Negative_regulation of Ptch1 1 0.02 0.22 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Ceroid Lipofuscinosis. They are ordered first by their pain relevance and then by number of times they were reported in Ceroid Lipofuscinosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT85659 Gene_expression of TPP1 2 0.53 1.84 0.48 98.84
2 INT30137 Negative_regulation of TPP1 5 0.37 0.96 2.2 98.68
3 INT317907 Gene_expression of DLGAP2 1 0.63 0.85 0 97.48
4 INT2761 Regulation of Gabrg1 119 0.61 18.8 60.52 95.76
5 INT51591 Regulation of GLUL 3 0.11 2.62 1.15 95.76
6 INT101931 Negative_regulation of CLN3 1 0.52 1.54 0.25 95.52
7 INT81155 Localization of CDCP1 5 0.08 4.49 1.4 95.36
8 INT14887 Gene_expression of Mbp 55 0.75 36.13 16.11 95.20
9 INT73239 Negative_regulation of Gene_expression of Mbp 6 0.46 5.65 1.96 95.20
10 INT159645 Negative_regulation of Uchl1 8 0.31 6.84 2.14 94.80
11 INT70017 Positive_regulation of BCL2 87 0.67 66.62 8.68 85.72
12 INT24519 Negative_regulation of ERG 15 0.38 6.98 1.33 84.28
13 INT6034 Binding of Gabrg1 115 0.47 17.48 51.92 81.44
14 INT101932 Negative_regulation of Gene_expression of TPP1 1 0.40 0.53 0.12 75.16
15 INT101934 Negative_regulation of Gene_expression of CLN3 1 0.38 0.53 0.12 75.16
16 INT35605 Positive_regulation of CELA3B 4 0.05 1.6 0.59 75.00
17 INT101935 Gene_expression of CLN3 1 0.70 0.53 0.12 74.80
18 INT8111 Localization of EPO 32 0.81 19.53 2.54 73.52
19 INT42251 Regulation of Gad1 10 0.44 5.25 3.45 70.16
20 INT3309 Binding of CP 25 0.47 17.87 6.62 68.76
21 INT230196 Positive_regulation of Transcription of PISRT1 1 0.34 0.4 0 62.96
22 INT230199 Regulation of Transcription of PISRT1 1 0.19 0.4 0 62.96
23 INT230193 Transcription of PISRT1 1 0.49 0.4 0 62.48
24 INT135337 Gene_expression of PTPRN2 2 0.72 0.82 0 60.00
25 INT317903 Gene_expression of NCAPG2 1 0.64 1.56 0 57.76
26 INT180240 Binding of Gad1 7 0.47 2.99 0.86 56.72
27 INT180242 Positive_regulation of Binding of Gad1 1 0.49 0.86 0.17 56.72
28 INT243220 Binding of Plxna2 1 0.06 0.87 0 56.64
29 INT87623 Gene_expression of PPT1 9 0.75 5.32 7.65 56.40
30 INT139281 Gene_expression of VIPR2 3 0.74 0.88 0.2 56.36
31 INT101933 Gene_expression of MCM6 1 0.01 0.6 0.14 55.40
32 INT317905 Gene_expression of ESYT2 1 0.64 0.76 0 54.36
33 INT180244 Positive_regulation of Gad2 4 0.49 1.07 0.61 53.48
34 INT317906 Gene_expression of WDR60 1 0.71 0.74 0 52.44
35 INT243222 Gene_expression of Rs1 6 0.78 8.49 0.17 51.44
36 INT243227 Transcription of Rs1 1 0.69 1.79 0 51.44
37 INT95699 Binding of Gad2 5 0.40 1.14 0.73 50.52
38 INT14843 Gene_expression of Gabrg1 301 0.77 62.63 139.16 44.88
39 INT230194 Negative_regulation of Gene_expression of PISRT1 1 0.30 0.81 0 44.44
40 INT230200 Gene_expression of PISRT1 1 0.53 0.8 0 44.44
41 INT25383 Gene_expression of Csf2 222 0.76 152.93 43.32 44.24
42 INT180243 Phosphorylation of Gad2 1 0.52 0.48 0.06 35.92
43 INT317912 Gene_expression of NCAPH2 1 0.06 0.74 0 35.60
44 INT114499 Gene_expression of MCPH1 38 0.67 26.68 4.55 29.48
45 INT28315 Regulation of Gene_expression of Gabrg1 20 0.60 4.78 7 14.64
46 INT42255 Negative_regulation of Gad1 7 0.56 4.83 2.54 10.80
47 INT180233 Negative_regulation of Negative_regulation of Uchl1 1 0.14 0.6 0.14 10.80
48 INT172370 Binding of MCPH1 6 0.34 4.75 0.13 9.80
49 INT317916 Binding of NCAPH2 1 0.04 0.53 0 9.40
50 INT308149 Gene_expression of Slc22a5 1 0.63 2.77 0.25 5.76
51 INT308141 Positive_regulation of Gene_expression of Slc22a5 1 0.56 0.44 0 5.76
52 INT51897 Binding of OPCML 8 0.43 5.59 1.11 5.36
53 INT120165 Binding of NTM 2 0.47 2.23 0.29 5.36
54 INT317915 Binding of SNX19 1 0.36 2.04 0.2 5.36
55 INT317919 Binding of VPS26B 1 0.23 0.93 0.1 5.36
56 INT317908 Binding of NCAPD3 1 0.32 0.91 0.1 5.36
57 INT317904 Binding of THYN1 1 0.32 0.96 0.1 5.36
58 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
59 INT6323 Positive_regulation of Gabrg1 213 0.70 45.08 124.34 5.00
60 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
61 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
62 INT9516 Negative_regulation of Gabrg1 149 0.53 27.83 91.02 5.00
63 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 5.00
64 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 5.00
65 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
66 INT163134 Gene_expression of ACR 78 0.65 30.39 38.48 5.00
67 INT3971 Positive_regulation of Alb 175 0.70 98.46 36.45 5.00
68 INT9694 Positive_regulation of Csf2 102 0.68 70.09 33.07 5.00
69 INT79395 Gene_expression of Twist1 193 0.77 100.06 26.34 5.00
70 INT70048 Positive_regulation of Gene_expression of IL10 90 0.55 71.34 25.66 5.00
71 INT47741 Negative_regulation of Flvcr2 43 0.51 5.72 23.37 5.00
72 INT22143 Gene_expression of Gad1 35 0.76 14.4 15.4 5.00
73 INT28314 Negative_regulation of Gene_expression of Gabrg1 29 0.44 12.56 13.8 5.00
74 INT69435 Negative_regulation of ROS1 74 0.51 50.38 13.71 5.00
75 INT80685 Gene_expression of MAPK8 90 0.72 51.91 13.36 5.00
76 INT73641 Regulation of Lep 45 0.62 26.2 12.59 5.00
77 INT39587 Gene_expression of CP 42 0.65 31.48 11.87 5.00
78 INT62919 Regulation of Gnas 22 0.43 5.61 9.55 5.00
79 INT96637 Gene_expression of Gad2 21 0.76 8.15 9.53 5.00
80 INT46273 Gene_expression of PRNP 103 0.78 110.34 9.25 5.00
81 INT15723 Gene_expression of Fn1 47 0.78 37.59 8.51 5.00
82 INT43820 Positive_regulation of Twist1 75 0.59 42.15 8.47 5.00
83 INT25392 Positive_regulation of Gene_expression of Csf2 41 0.49 34.28 8.36 5.00
84 INT27591 Negative_regulation of Gene_expression of Alb 30 0.58 17.03 5.99 5.00
85 INT25394 Negative_regulation of Gene_expression of Csf2 22 0.52 13.18 5.84 5.00
86 INT56149 Localization of CD8A 56 0.74 30.41 5.75 5.00
87 INT142162 Binding of IL10 30 0.37 21.9 4.84 5.00
88 INT11565 Gene_expression of Tf 24 0.68 5.89 4.36 5.00
89 INT20230 Negative_regulation of Positive_regulation of Alb 15 0.56 12.44 4.11 5.00
90 INT180250 Positive_regulation of GLUL 23 0.29 7.57 3.23 5.00
91 INT70596 Regulation of Uchl1 5 0.39 3.87 3.11 5.00
92 INT116540 Binding of Twist1 35 0.48 16.32 2.85 5.00
93 INT173336 Gene_expression of GLUL 16 0.27 6.74 2.78 5.00
94 INT165514 Regulation of Gad2 7 0.45 3.15 2.76 5.00
95 INT221097 Negative_regulation of Atp8a1 15 0.57 10.52 2.65 5.00
96 INT8466 Binding of Plp1 5 0.48 5.07 2.29 5.00
97 INT42256 Positive_regulation of Gad1 4 0.66 1.1 2.09 5.00
98 INT80857 Negative_regulation of Cpt2 19 0.42 12.1 1.6 5.00
99 INT12890 Gene_expression of Ttr 15 0.63 7.68 1.6 5.00
100 INT96642 Transcription of Gad2 4 0.59 0.88 1.59 5.00
101 INT180238 Regulation of Gene_expression of Twist1 13 0.61 4.87 1.59 5.00
102 INT185649 Regulation of ERG 17 0.20 10.14 1.49 5.00
103 INT180249 Negative_regulation of GLUL 5 0.15 0.69 1.46 5.00
104 INT90567 Negative_regulation of Gene_expression of Gad1 4 0.41 2.88 1.36 5.00
105 INT141131 Positive_regulation of Gene_expression of PRNP 12 0.61 16.6 1.36 5.00
106 INT36500 Negative_regulation of Gene_expression of Tf 4 0.38 1.22 1.29 5.00
107 INT16427 Negative_regulation of Positive_regulation of Csf2 2 0.43 1.5 1.2 5.00
108 INT56386 Positive_regulation of UBXN11 6 0.49 2.79 1.05 5.00
109 INT15726 Negative_regulation of Gene_expression of Fn1 8 0.32 5.25 1.04 5.00
110 INT48687 Gene_expression of Plp1 7 0.54 3.51 1.03 5.00
111 INT158651 Gene_expression of Plxna2 9 0.66 1.98 0.98 5.00
112 INT90568 Regulation of Gene_expression of Gad1 3 0.27 0.46 0.89 5.00
113 INT23913 Negative_regulation of Gene_expression of Ttr 3 0.15 2.8 0.87 5.00
114 INT47055 Gene_expression of RBP1 8 0.75 7.85 0.86 5.00
115 INT39586 Transcription of CP 5 0.67 1.7 0.83 5.00
116 INT96649 Gene_expression of ARSA 5 0.65 2.82 0.8 5.00
117 INT182293 Binding of MAPK8 11 0.34 4.6 0.77 5.00
118 INT68446 Negative_regulation of Cpt1a 5 0.38 6.5 0.56 5.00
119 INT180239 Negative_regulation of Gene_expression of Gad2 2 0.42 1.59 0.55 5.00
120 INT51895 Localization of OPCML 6 0.68 3.43 0.54 5.00
121 INT176891 Negative_regulation of Localization of CD8A 4 0.22 2.58 0.49 5.00
122 INT115039 Positive_regulation of FMR1 4 0.49 2.26 0.46 5.00
123 INT162843 Negative_regulation of Gene_expression of CP 2 0.11 2.79 0.45 5.00
124 INT180234 Negative_regulation of Gene_expression of Plp1 1 0.08 1.54 0.42 5.00
125 INT39150 Gene_expression of Pcbd1 5 0.28 1.3 0.38 5.00
126 INT243226 Positive_regulation of Rs1 3 0.70 5.6 0.31 5.00
127 INT9034 Regulation of Pcbd1 6 0.20 3.28 0.28 5.00
128 INT244343 Localization of NTM 16 0.73 14.26 0.26 5.00
129 INT317920 Localization of SNX19 1 0.73 1.88 0.2 5.00
130 INT180236 Binding of Etv5 2 0.36 1.09 0.18 5.00
131 INT308147 Gene_expression of Slc22a4 1 0.33 1.55 0.17 5.00
132 INT308146 Localization of Nme1 1 0.01 1.34 0.16 5.00
133 INT308140 Localization of Cpt1a 1 0.30 1.34 0.16 5.00
134 INT180237 Binding of Tbca 2 0.03 1.08 0.15 5.00
135 INT132294 Positive_regulation of Sptlc1 3 0.31 3.84 0.14 5.00
136 INT317913 Gene_expression of SHANK3 1 0.64 2.19 0.13 5.00
137 INT228583 Regulation of Cpt1a 4 0.40 1.42 0.11 5.00
138 INT243231 Localization of Rs1 2 0.67 2.15 0.1 5.00
139 INT243228 Protein_catabolism of Ighmbp2 3 0.16 0.83 0.1 5.00
140 INT317910 Localization of THYN1 1 0.65 0.88 0.1 5.00
141 INT317911 Localization of VPS26B 1 0.47 0.88 0.1 5.00
142 INT317914 Localization of NCAPD3 1 0.65 0.88 0.1 5.00
143 INT317918 Gene_expression of MAPK8IP2 2 0.59 1.43 0.09 5.00
144 INT308139 Negative_regulation of Slc22a4 1 0.21 0.79 0.08 5.00
145 INT58917 Negative_regulation of Zdhhc7 2 0.51 1.06 0.08 5.00
146 INT308137 Regulation of Gcdh 1 0.18 0.8 0.06 5.00
147 INT308143 Regulation of Regulation of Cpt1a 1 0.22 1.06 0.05 5.00
148 INT243229 Localization of Xmmv63 1 0.73 1.18 0.04 5.00
149 INT308142 Positive_regulation of Cpt1a 1 0.23 2.64 0.04 5.00
150 INT243221 Positive_regulation of Localization of Xmmv63 1 0.49 1.19 0.04 5.00
151 INT243230 Positive_regulation of Localization of Rs1 1 0.44 1.18 0.04 5.00
152 INT180241 Positive_regulation of Binding of Gad2 1 0.39 0.29 0.03 5.00
153 INT230181 Binding of Aurka 2 0.35 0.63 0.03 5.00
154 INT243225 Binding of Rs1 2 0.33 1.32 0.03 5.00
155 INT317917 Gene_expression of RABL2B 1 0.61 0.68 0.03 5.00
156 INT317909 Binding of MAPK8IP2 1 0.31 0.84 0.03 5.00
157 INT308145 Binding of Slc22a5 1 0.39 0.14 0 5.00
158 INT308158 Regulation of CPT1B 1 0.08 0.18 0 5.00
159 INT243224 Regulation of Plxna2 2 0.13 1.58 0 5.00
160 INT230198 Gene_expression of LDLRAP1 1 0.06 0.87 0 5.00
161 INT180251 Gene_expression of ERCC4 1 0.65 0 0 5.00
162 INT308160 Transcription of UBXN11 1 0.67 1.48 0 5.00
163 INT243223 Negative_regulation of Rs1 1 0.43 1.3 0 5.00
164 INT295500 Transcription of Cpt1a 2 0.63 1.65 0 5.00
165 INT230195 Negative_regulation of LDLRAP1 1 0.04 0.88 0 5.00
166 INT308148 Positive_regulation of Slc22a5 1 0.56 0.58 0 5.00
167 INT308159 Positive_regulation of Transcription of UBXN11 1 0.49 1.49 0 5.00
168 INT295510 Negative_regulation of Sptlc1 4 0.11 2.11 0 5.00
169 INT308161 Negative_regulation of CPT1B 1 0.08 0.46 0 5.00
170 INT180232 Protein_catabolism of Gad1 1 0.87 0.52 0 5.00
171 INT308144 Gene_expression of Rhox5 2 0.11 1.21 0 5.00
172 INT308138 Positive_regulation of Transcription of Cpt1a 1 0.25 1.49 0 5.00
173 INT230197 Binding of LDLRAP1 1 0.03 0.63 0 5.00
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox