D:Cervical Intraepithelial Neoplasia

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Disease Term
Synonyms Cervical Intraepithelial Neoplasia Grade Iii, Cervical Intraepithelial Neoplasm, CERVICAL INTRAEPITHELIAL NEOPLASMS, Intraepithelial Neoplasia Cervical, Intraepithelial Neoplasm Cervical, Intraepithelial Neoplasms Cervical, NEOPLASIA CERVICAL INTRAEPITHELIAL, Neoplasm Cervical Intraepithelial, Neoplasms Cervical Intraepithelial
Documents 100
Hot Single Events 20
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Cervical Intraepithelial Neoplasia. They are ordered first by their relevance to Cervical Intraepithelial Neoplasia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT259082 Binding of HPV18I1 and Hbb-ar 1 0.00 1.36 0 25.32
2 INT259081 Binding of Hbb-ar and ENOPH1 1 0.00 1.36 0 25.16
3 INT190702 CD40 Positive_regulation of Gene_expression of F3 1 0.00 1.4 0.55 5.00
4 INT230065 Binding of TOR1A and HLA-DOA 1 0.00 1.65 0.09 5.00
5 INT232917 Binding of KRT8 and KRT19 2 0.16 1.04 0.08 5.00
6 INT232914 Binding of KRT2 and KRT7 1 0.15 0.63 0.05 5.00
7 INT232916 Binding of KRT2 and KRT19 1 0.21 0.62 0.05 5.00
8 INT232907 Binding of KRT7 and KRT8 1 0.09 0.63 0.05 5.00
9 INT230066 IL15 Positive_regulation of Gene_expression of KLRD1 1 0.01 0.37 0.03 5.00
10 INT232918 Binding of KRT2 and KRT8 1 0.17 0.59 0 5.00
11 INT259050 Binding of HPV18I1 and OPN1LW 1 0.01 1.19 0 5.00
12 INT232912 Binding of KRT4 and KRT13 1 0.07 0.06 0 5.00
13 INT232910 Binding of KRT12 and KRT76 1 0.39 0.2 0 5.00
14 INT232911 Binding of KRT18 and PLAT 1 0.05 1.3 0 5.00
15 INT259049 Binding of BAK1 and HPV18I1 1 0.00 1.19 0 5.00
16 INT232915 Binding of KRT8 and PLAT 1 0.04 1.3 0 5.00
17 INT232909 Binding of KRT1 and KRT9 1 0.16 0.5 0 5.00
18 INT232913 Binding of KRT3 and NBPF14 1 0.01 0.21 0 5.00
19 INT232908 Binding of KRT19 and PLAT 1 0.05 1.31 0 5.00
20 INT232906 Binding of KRT1 and KRT10 1 0.18 0.51 0 5.00
21 INT259051 Binding of TP53 and UBE3A 1 0.01 3.48 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Cervical Intraepithelial Neoplasia. They are ordered first by their pain relevance and then by number of times they were reported in Cervical Intraepithelial Neoplasia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT62296 Gene_expression of PDXP 8 0.67 6.48 1.44 100.00
2 INT147582 Negative_regulation of AIS 13 0.37 13.26 2.46 100.00
3 INT216867 Localization of PDXP 4 0.28 6.31 0.62 100.00
4 INT88870 Negative_regulation of PDXP 4 0.43 4.64 0.57 100.00
5 INT39358 Regulation of PDXP 3 0.23 2.7 0.63 100.00
6 INT216868 Positive_regulation of Localization of PDXP 1 0.15 2.37 0.03 100.00
7 INT55002 Gene_expression of ASAP1 46 0.64 22.8 3.2 99.96
8 INT227017 Gene_expression of KRT17 2 0.45 14.84 0.41 99.84
9 INT6302 Binding of IFNA1 196 0.48 133.85 32.73 99.82
10 INT5871 Binding of IFNA2 38 0.48 20.35 6.46 99.82
11 INT32946 Positive_regulation of TADA1 1 0.36 1.31 0.1 99.64
12 INT32945 Binding of IFNB1 3 0.48 2.17 0.58 97.24
13 INT198710 Phosphorylation of LCH 1 0.53 1.16 0 86.84
14 INT71602 Negative_regulation of Trp53 84 0.59 67.77 3.68 84.48
15 INT56925 Negative_regulation of TSC1 54 0.52 63.39 1.87 84.48
16 INT196916 Negative_regulation of Rb1 13 0.42 14.29 0.4 84.48
17 INT217832 Negative_regulation of Gene_expression of TSC1 5 0.04 5.45 0.21 84.48
18 INT53487 Gene_expression of TSC1 81 0.58 77.71 7.94 83.32
19 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65 82.44
20 INT169907 Gene_expression of Rb1 25 0.60 21.95 1.32 82.44
21 INT198709 Localization of LCH 1 0.78 3.27 0.1 80.00
22 INT191823 Positive_regulation of TGM2 2 0.30 1.95 0.25 74.84
23 INT4988 Gene_expression of KRT1 64 0.77 43.4 4.12 71.48
24 INT232994 Gene_expression of KRT10 6 0.40 8.2 0.03 71.40
25 INT92941 Binding of ASAP1 24 0.39 12.38 1.25 69.84
26 INT256913 Gene_expression of Hr 6 0.46 35.3 0.1 69.44
27 INT91370 Phosphorylation of STAT3 123 0.82 49.25 8.42 69.40
28 INT38834 Positive_regulation of Positive_regulation of PPY 2 0.42 4.18 0.61 68.68
29 INT3180 Positive_regulation of PPY 39 0.63 25.57 10.15 68.36
30 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 66.88
31 INT61619 Gene_expression of IL12A 194 0.77 146.07 41.97 65.84
32 INT341719 Transcription of FAM49B 1 0.04 1.1 0 65.60
33 INT341718 Positive_regulation of Transcription of FAM49B 1 0.03 1.1 0 65.60
34 INT198708 Gene_expression of LCH 1 0.57 2.93 0 64.72
35 INT259058 Transcription of HPV18I1 3 0.01 9.81 0 61.96
36 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 58.08
37 INT159190 Gene_expression of KRT5 31 0.65 26.67 0.56 56.88
38 INT187628 Gene_expression of KRT14 15 0.75 11.54 0.1 56.88
39 INT225959 Gene_expression of KRT15 7 0.48 2.01 0 56.88
40 INT259079 Regulation of Hc2 1 0.04 0.72 0 48.84
41 INT44544 Gene_expression of ENOPH1 18 0.76 10.28 2.35 43.72
42 INT179299 Binding of TGM2 3 0.24 1.02 0 40.80
43 INT222311 Gene_expression of IGKV1-16 4 0.15 4.64 0.3 35.28
44 INT35011 Gene_expression of PPFIBP1 3 0.48 4.52 0.08 35.28
45 INT68285 Gene_expression of SERPINB3 24 0.75 25.4 0.45 33.48
46 INT132969 Gene_expression of HPV18I1 4 0.27 10.84 0.05 29.72
47 INT259059 Regulation of HPV18I1 3 0.00 5.16 0 29.56
48 INT102272 Regulation of TH1L 41 0.44 30.89 11.63 28.80
49 INT93359 Positive_regulation of Trp53 90 0.70 69.77 6.24 27.84
50 INT242321 Negative_regulation of Gene_expression of Asap1 1 0.20 1.96 0 26.76
51 INT20611 Gene_expression of Asap1 55 0.65 23.71 14.62 26.24
52 INT232942 Negative_regulation of KRT10 3 0.21 1.19 0 21.08
53 INT18969 Gene_expression of HLA-DQA1 29 0.65 12.19 2.54 17.20
54 INT45168 Negative_regulation of ASAP1 23 0.58 10.15 2.44 16.64
55 INT115501 Gene_expression of TGM2 8 0.64 4.56 0.28 16.32
56 INT70445 Binding of KRT1 10 0.35 5.38 0.47 13.00
57 INT232965 Binding of KRT10 3 0.19 1.66 0 12.72
58 INT198711 Binding of NCK1 1 0.05 1.08 0.03 7.76
59 INT1108 Gene_expression of PPY 58 0.75 36.57 10.76 5.60
60 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
61 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
62 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
63 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
64 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
65 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
66 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
67 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
68 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
69 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
70 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
71 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
72 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 5.00
73 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 5.00
74 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
75 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
76 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31 5.00
77 INT73502 Positive_regulation of IL10 154 0.69 124.87 43.5 5.00
78 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 5.00
79 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38 5.00
80 INT72651 Gene_expression of TH1L 114 0.75 80.15 35.15 5.00
81 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67 5.00
82 INT11325 Gene_expression of HLA-E 209 0.76 98.05 33.72 5.00
83 INT10763 Localization of IL2 157 0.80 81.11 33.21 5.00
84 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
85 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7 5.00
86 INT34729 Positive_regulation of IFN1@ 233 0.67 128.04 30.38 5.00
87 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 5.00
88 INT19856 Gene_expression of CD8A 240 0.75 147.86 26.39 5.00
89 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 5.00
90 INT79395 Gene_expression of Twist1 193 0.77 100.06 26.34 5.00
91 INT74423 Localization of IL10 91 0.80 61.6 22.95 5.00
92 INT62042 Positive_regulation of Gene_expression of IL4 67 0.56 42.05 20.39 5.00
93 INT70614 Gene_expression of FAS 118 0.75 112.33 19.01 5.00
94 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9 5.00
95 INT192409 Positive_regulation of Gene_expression of IFN1@ 102 0.67 64.66 18.8 5.00
96 INT56301 Positive_regulation of IL4 68 0.56 54.51 18.65 5.00
97 INT38056 Localization of Crp 71 0.78 53.14 17.03 5.00
98 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 5.00
99 INT19929 Negative_regulation of Positive_regulation of TNF 52 0.59 38.16 16.51 5.00
100 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 5.00
101 INT8571 Gene_expression of B3GAT1 54 0.75 36.85 15.98 5.00
102 INT170754 Localization of IFN1@ 121 0.78 66.78 15.6 5.00
103 INT171666 Regulation of GOPC 117 0.39 40.41 15.47 5.00
104 INT81627 Gene_expression of Fas 120 0.78 115.51 15.36 5.00
105 INT116465 Gene_expression of Birc5 241 0.78 192.31 15.32 5.00
106 INT75540 Positive_regulation of TH1L 62 0.67 43.45 15.02 5.00
107 INT59870 Gene_expression of F3 51 0.65 51.83 14.01 5.00
108 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61 5.00
109 INT11699 Binding of HLA-E 85 0.47 52.51 13.41 5.00
110 INT172171 Gene_expression of IL15 47 0.37 46.23 13.41 5.00
111 INT53747 Positive_regulation of Cyp2e1 34 0.70 29.03 13.39 5.00
112 INT61624 Positive_regulation of Gene_expression of IL12A 50 0.56 33.07 13.07 5.00
113 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54 5.00
114 INT28952 Negative_regulation of Gene_expression of IGF1 75 0.58 41.11 12.32 5.00
115 INT148207 Gene_expression of CTLA4 53 0.77 29.13 12.07 5.00
116 INT48335 Negative_regulation of NOSTRIN 38 0.56 16.22 12.05 5.00
117 INT69158 Localization of IL4 48 0.71 31.3 11.98 5.00
118 INT111476 Gene_expression of TP63 88 0.76 61.08 11.64 5.00
119 INT69029 Gene_expression of PTPRC 127 0.75 74.26 11.57 5.00
120 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 5.00
121 INT23402 Binding of HLA-DOA 74 0.48 52.01 10.89 5.00
122 INT22132 Positive_regulation of CAT 41 0.67 18.64 10.67 5.00
123 INT58904 Localization of TH1L 40 0.68 27.11 10.52 5.00
124 INT69306 Negative_regulation of TH1L 28 0.57 24.81 9.74 5.00
125 INT170333 Binding of IFN1@ 68 0.47 49.01 9.72 5.00
126 INT43820 Positive_regulation of Twist1 75 0.59 42.15 8.47 5.00
127 INT28671 Positive_regulation of Gene_expression of HLA-E 43 0.67 22.85 8.39 5.00
128 INT86639 Gene_expression of KRT16 19 0.68 12.44 7.79 5.00
129 INT95133 Gene_expression of FASLG 38 0.75 44.09 7.51 5.00
130 INT91667 Localization of IL12A 39 0.74 25.51 7.36 5.00
131 INT31226 Localization of PPY 20 0.78 9.93 6.8 5.00
132 INT132822 Localization of IL13 26 0.67 22.85 6.66 5.00
133 INT38672 Binding of KRT20 69 0.39 48.01 6.31 5.00
134 INT8683 Positive_regulation of F3 31 0.67 42.89 6.21 5.00
135 INT75501 Gene_expression of CCND1 90 0.76 60.86 5.93 5.00
136 INT11360 Localization of SERPINE1 41 0.80 33.98 5.61 5.00
137 INT38671 Positive_regulation of KRT20 62 0.53 40.17 5.6 5.00
138 INT125467 Positive_regulation of Gene_expression of CDKN2A 35 0.63 39.07 5.56 5.00
139 INT38670 Positive_regulation of Gene_expression of KRT20 68 0.69 23.25 5.55 5.00
140 INT23401 Gene_expression of HLA-DOA 91 0.30 38.21 5.52 5.00
141 INT89794 Positive_regulation of CDKN2A 58 0.67 50.18 5.38 5.00
142 INT69156 Localization of IL5 21 0.68 14.95 5.37 5.00
143 INT94028 Regulation of Twist1 37 0.44 22.41 5.33 5.00
144 INT60585 Regulation of TP53 59 0.59 54.55 5.21 5.00
145 INT73262 Negative_regulation of BCL2 67 0.57 61.01 5.07 5.00
146 INT15797 Positive_regulation of HLA-E 36 0.67 15.17 5.07 5.00
147 INT83735 Gene_expression of Foxm1 41 0.77 22.9 5.07 5.00
148 INT85415 Positive_regulation of IL9 10 0.28 6.93 4.71 5.00
149 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62 5.00
150 INT151230 Positive_regulation of IL7 14 0.37 11.89 4.56 5.00
151 INT57749 Negative_regulation of Gene_expression of TP53 39 0.56 36.79 4.45 5.00
152 INT89963 Regulation of Fas 15 0.59 8.25 4.32 5.00
153 INT75136 Binding of Akt1 27 0.27 8.81 4.15 5.00
154 INT84686 Regulation of BAX 26 0.49 28.54 4.13 5.00
155 INT182311 Positive_regulation of Birc5 26 0.67 25.32 4.08 5.00
156 INT111477 Gene_expression of KRT7 90 0.74 86.76 4.07 5.00
157 INT101857 Negative_regulation of BCL2L1 22 0.57 23.56 3.95 5.00
158 INT29138 Positive_regulation of Localization of IL2 25 0.50 10.06 3.89 5.00
159 INT97126 Regulation of CASP3 9 0.40 8.15 3.6 5.00
160 INT187819 Regulation of IFN1@ 25 0.60 12.89 3.55 5.00
161 INT89966 Negative_regulation of Fas 26 0.58 24.83 3.5 5.00
162 INT78471 Regulation of Gene_expression of CDKN2A 13 0.45 12.52 3.28 5.00
163 INT184060 Negative_regulation of Stat1 28 0.58 17.44 3.19 5.00
164 INT32852 Negative_regulation of FECH 18 0.57 10.59 3.08 5.00
165 INT86640 Positive_regulation of Gene_expression of KRT16 5 0.61 2.5 2.99 5.00
166 INT78467 Negative_regulation of IL12A 18 0.38 11.29 2.98 5.00
167 INT172177 Protein_catabolism of INCENP 18 0.37 6.34 2.91 5.00
168 INT239083 Binding of PPY 9 0.32 7.59 2.9 5.00
169 INT84527 Positive_regulation of Gene_expression of F3 16 0.49 15.83 2.85 5.00
170 INT90094 Gene_expression of Cytl1 14 0.75 12.75 2.81 5.00
171 INT50335 Positive_regulation of Foxm1 20 0.69 5.11 2.81 5.00
172 INT38673 Negative_regulation of KRT20 38 0.42 22.49 2.77 5.00
173 INT221269 Binding of BRCA1 14 0.40 31.77 2.7 5.00
174 INT90875 Negative_regulation of CCND1 31 0.42 26.22 2.66 5.00
175 INT90038 Negative_regulation of Ifnar2 4 0.35 1.69 2.58 5.00
176 INT119838 Positive_regulation of PTEN 25 0.67 21.71 2.5 5.00
177 INT72782 Positive_regulation of HCC 41 0.40 63.74 2.46 5.00
178 INT226453 Positive_regulation of Gene_expression of IL15 9 0.24 12.66 2.38 5.00
179 INT182312 Positive_regulation of Gene_expression of Birc5 26 0.69 25.3 2.32 5.00
180 INT73266 Gene_expression of RB1 50 0.70 29.09 2.31 5.00
181 INT182318 Regulation of Birc5 25 0.60 23.58 2.29 5.00
182 INT94002 Regulation of Lox 13 0.38 8.41 2.29 5.00
183 INT46088 Localization of F3 15 0.37 13.7 2.23 5.00
184 INT116194 Gene_expression of Casp8 14 0.75 14.61 2.13 5.00
185 INT73476 Transcription of MYC 18 0.69 12.14 2.13 5.00
186 INT111143 Regulation of Gene_expression of KRT20 22 0.26 5.65 1.93 5.00
187 INT155015 Positive_regulation of HLA-DOA 6 0.23 4.45 1.92 5.00
188 INT65855 Localization of TP53 18 0.76 17.08 1.89 5.00
189 INT121784 Regulation of Gene_expression of Fas 7 0.38 5.68 1.86 5.00
190 INT221791 Transcription of TH1L 4 0.45 3.98 1.84 5.00
191 INT85084 Gene_expression of KRT19 66 0.73 42.56 1.82 5.00
192 INT73475 Positive_regulation of Transcription of MYC 7 0.67 5.46 1.66 5.00
193 INT233010 Gene_expression of PERP 5 0.26 6.04 1.66 5.00
194 INT68094 Negative_regulation of SERPINB3 12 0.43 10.55 1.49 5.00
195 INT93001 Localization of CD40 4 0.78 1.97 1.45 5.00
196 INT162469 Positive_regulation of Protein_catabolism of TP53 5 0.52 5.48 1.42 5.00
197 INT162462 Protein_catabolism of TP53 8 0.86 7.89 1.41 5.00
198 INT201463 Negative_regulation of CCNE2 7 0.39 3.31 1.36 5.00
199 INT74178 Gene_expression of HMBS 24 0.76 9.62 1.36 5.00
200 INT137382 Negative_regulation of Gene_expression of KRT20 22 0.58 12.29 1.29 5.00
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