D:Charcot Marie Tooth Disease

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Disease Term
Synonyms ATROPHIES PERONEAL MUSCULAR, ATROPHY MUSCULAR PERONEAL, Atrophy Peroneal Muscular, CHARCOT, Charcot Marie Disease, Charcot Marie Tooth, Charcot Marie Tooth Atrophy, Charcot Marie Tooth Disease Type I, Charcot Marie Tooth Disease Type Ia, Charcot Marie Tooth Disease Type Ib, Charcot Marie Tooth Disease Type Ii
Documents 515
Hot Single Events 84
Hot Interactions 9

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Charcot Marie Tooth Disease. They are ordered first by their relevance to Charcot Marie Tooth Disease and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT164249 Binding of MPZ and Mpz 1 0.06 2.13 0.24 100.00
2 INT266419 HMGB1 Positive_regulation of Ager 1 0.01 1.37 0.37 95.20
3 INT266375 S100b Positive_regulation of Ager 1 0.02 1.8 0.31 95.20
4 INT266385 S100a6 Positive_regulation of Ager 1 0.01 0.84 0.1 95.20
5 INT266373 Itgam Positive_regulation of Ager 1 0.01 0.84 0.1 95.20
6 INT165324 Binding of TRPV4 and Trpv4 1 0.11 0.66 0.1 94.48
7 INT234831 Binding of SPTLC1 and Abo 1 0.00 1.61 0.23 91.04
8 INT120870 Binding of Wnk1 and Sptlc1 1 0.14 1.24 0.56 89.96
9 INT283002 Binding of Bak1 and Mgst1 1 0.01 0.24 0 80.92
10 INT194324 Binding of MPZ and MAD2L1BP 1 0.02 0.62 0.04 79.28
11 INT302676 Binding of OPA1 and MFN2 1 0.46 1.12 0.14 77.72
12 INT153620 Binding of Ntrk1 and WNK1 1 0.02 0.85 0.12 76.08
13 INT234801 RAB3GAP1 Regulation of RAB3A 1 0.08 1.64 0.15 65.32
14 INT329005 Binding of TSG101 and LITAF 1 0.04 1.41 0 64.08
15 INT329007 Binding of MPZ and TSG101 1 0.01 0.71 0 64.08
16 INT298873 RAB7A Regulation of Protein_catabolism of NTRK1 1 0.12 0.25 0.03 63.84
17 INT283543 Binding of GARS and Setx 1 0.01 3.71 0 62.68
18 INT283542 Binding of SPG19 and Setx 1 0.06 3.69 0 62.68
19 INT329013 Binding of LITAF and Nedd4 1 0.15 1.4 0 61.28
20 INT329012 Binding of MPZ and Nedd4 1 0.03 0.7 0 61.28
21 INT329008 Binding of LITAF and RNF123 1 0.01 1.39 0 59.76
22 INT329004 Binding of MPZ and RNF123 1 0.00 0.7 0 59.76
23 INT194333 Binding of MFN2 and Racgap1 1 0.01 0.38 0 58.16
24 INT298872 RAB7A Regulation of Protein_catabolism of GFM1 1 0.47 0.22 0.03 57.20
25 INT283533 Binding of GARS and SPG19 1 0.00 1.72 0 56.48
26 INT266413 Positive_regulation of Binding of HMGB1 and Col4a1 1 0.02 1.05 0.14 51.80
27 INT266411 Binding of HMGB1 and Col4a1 1 0.01 1.05 0.14 51.36
28 INT307665 Binding of Mpz and Pmp22 1 0.34 0.39 0.08 50.00
29 INT307666 Binding of Pmp22 and Gjb1 1 0.31 0.38 0.08 50.00
30 INT307663 Binding of Pmp22 and Egr2 1 0.33 0.39 0.08 50.00
31 INT307664 Binding of Pmp22 and LOC689781 1 0.03 0.39 0.08 50.00
32 INT308030 Binding of Mpz and ASPM 1 0.02 0.55 0 50.00
33 INT308029 ASPM Positive_regulation of Regulation of Mpz 1 0.02 0.55 0 50.00
34 INT203406 Cap2 Negative_regulation of Rtn4 1 0.07 0.59 0 28.28
35 INT203409 Cap2 Negative_regulation of Bex1 1 0.07 0.58 0 28.28
36 INT203408 Vsnl1 Negative_regulation of Cap2 1 0.15 0.58 0 28.28
37 INT203407 Cap2 Negative_regulation of Nptn 1 0.06 0.59 0 28.28
38 INT203413 Cap2 Negative_regulation of Rtn1 1 0.06 0.59 0 28.28
39 INT203404 Cap2 Negative_regulation of Chn1 1 0.06 0.58 0 28.28
40 INT203402 Enc1 Negative_regulation of Rtn1 1 0.07 0.58 0 28.04
41 INT203418 Enc1 Negative_regulation of Rtn4 1 0.08 0.58 0 28.04
42 INT203398 Enc1 Negative_regulation of Nptn 1 0.07 0.59 0 28.04
43 INT203397 Enc1 Negative_regulation of Chn1 1 0.08 0.58 0 28.04
44 INT203403 Enc1 Negative_regulation of Bex1 1 0.08 0.58 0 28.04
45 INT203411 Mllt11 Negative_regulation of Nptn 1 0.08 0.58 0 27.80
46 INT203417 Mllt11 Negative_regulation of Rtn1 1 0.08 0.58 0 27.80
47 INT203416 Mllt11 Negative_regulation of Chn1 1 0.09 0.58 0 27.80
48 INT203393 Mllt11 Negative_regulation of Bex1 1 0.09 0.58 0 27.80
49 INT203396 Mllt11 Negative_regulation of Rtn4 1 0.09 0.58 0 27.80
50 INT203400 Olfm1 Negative_regulation of Bex1 1 0.09 0.58 0 27.48
51 INT203415 Olfm1 Negative_regulation of Chn1 1 0.08 0.58 0 27.48
52 INT203392 Olfm1 Negative_regulation of Nptn 1 0.08 0.58 0 27.48
53 INT203399 Olfm1 Negative_regulation of Rtn4 1 0.09 0.58 0 27.48
54 INT203391 Olfm1 Negative_regulation of Rtn1 1 0.08 0.58 0 27.48
55 INT203405 Vsnl1 Negative_regulation of Bex1 1 0.19 0.58 0 27.20
56 INT203414 Vsnl1 Negative_regulation of Nptn 1 0.16 0.58 0 27.20
57 INT203394 Vsnl1 Negative_regulation of Chn1 1 0.17 0.58 0 27.20
58 INT203410 Vsnl1 Negative_regulation of Rtn4 1 0.18 0.58 0 27.20
59 INT203401 Vsnl1 Negative_regulation of Rtn1 1 0.17 0.58 0 27.20
60 INT238805 Binding of DSP and HSPB2 1 0.09 4.2 0.13 15.04
61 INT234795 Negative_regulation of CHM Negative_regulation of RAB27A 1 0.01 0.8 0 14.00
62 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 0.59 9.37 4.48 5.00
63 INT64719 IL1B Positive_regulation of IL6 7 0.41 6.84 3.14 5.00
64 INT115367 Binding of IL6 and IL6R 12 0.07 8.16 2.36 5.00
65 INT183781 Binding of IL6 and INS 6 0.22 8.97 1.87 5.00
66 INT266391 Binding of Ager and S100a1 1 0.01 5.63 1.69 5.00
67 INT266406 Binding of APP and Ager 1 0.00 2.34 1.57 5.00
68 INT209409 Binding of CALM1 and NHS 2 0.27 0.58 1.32 5.00
69 INT55162 Binding of NFKB1 and RELA 10 0.30 2.82 1.18 5.00
70 INT231391 Binding of Lpar1 and Rbm39 1 0.00 1.04 1.04 5.00
71 INT206074 Binding of IL6 and IL6ST 7 0.32 3.79 1.01 5.00
72 INT344973 Negative_regulation of Mmp23 Regulation of Negative_regulation of Mag 1 0.01 1.14 0.99 5.00
73 INT231392 Enpp2 Positive_regulation of Gene_expression of Lpar1 2 0.38 2.19 0.93 5.00
74 INT231390 Pla2g4a Regulation of Pla2g2a 1 0.08 0.92 0.77 5.00
75 INT231388 Pla2g4a Regulation of Pla2g6 1 0.08 0.92 0.77 5.00
76 INT183698 Binding of Cxcr2 and Cxcl1 3 0.33 3.26 0.76 5.00
77 INT344974 Lpar1 Regulation of Gene_expression of Mag 1 0.25 0.98 0.76 5.00
78 INT266408 Binding of HMGB1 and Ager 1 0.01 2.57 0.76 5.00
79 INT334395 IL1B Positive_regulation of Tnf 1 0.11 2.83 0.69 5.00
80 INT110835 Binding of SPTLC2 and SPTLC1 2 0.42 1.36 0.68 5.00
81 INT316690 Binding of Myd88 and Il1 2 0.06 1.75 0.66 5.00
82 INT64956 IRF6 Positive_regulation of Gene_expression of IL6 4 0.19 1.4 0.63 5.00
83 INT316695 Binding of Il1 and gout 1 0.00 1.55 0.62 5.00
84 INT181084 Binding of S100a8 and S100a9 6 0.42 2.91 0.62 5.00
85 INT266381 Positive_regulation of Ager Positive_regulation of Nfkb1 1 0.00 0.77 0.55 5.00
86 INT266376 Binding of Ager and Itgam 1 0.00 2.31 0.54 5.00
87 INT164902 Binding of IL1RL1 and IL33 4 0.37 1.2 0.53 5.00
88 INT115186 IL6 Positive_regulation of Phosphorylation of STAT3 2 0.19 0.35 0.48 5.00
89 INT316694 Binding of BLZF1 and Nlrp2 1 0.00 0.75 0.45 5.00
90 INT297229 Binding of Kcnj8 and Abcc8 1 0.03 0 0.42 5.00
91 INT266393 Binding of Ager and Fn1 1 0.00 0.82 0.39 5.00
92 INT266382 Binding of Col4a1 and Fn1 1 0.00 0.82 0.39 5.00
93 INT266397 Binding of Ager and Col4a1 1 0.00 0.81 0.38 5.00
94 INT110834 Binding of AGXT and SPTLC2 2 0.27 0.71 0.36 5.00
95 INT334393 IL6 Positive_regulation of Tnf 1 0.16 1.41 0.35 5.00
96 INT316689 Gene_expression of Cd14 Negative_regulation of Gene_expression of Il1 1 0.09 1.31 0.35 5.00
97 INT316691 Negative_regulation of Cd14 Negative_regulation of Gene_expression of Il1 1 0.09 1.31 0.35 5.00
98 INT203395 Edn1 Positive_regulation of Vegfa 1 0.06 1.59 0.35 5.00
99 INT266402 Binding of S100P and Ager 1 0.00 2.25 0.35 5.00
100 INT266383 Binding of Ager and S100b 1 0.01 3.48 0.33 5.00
101 INT229785 Binding of RAB7A and SPTLC1 1 0.40 1.5 0.27 5.00
102 INT319383 Binding of CCL18 and CCL22 1 0.19 1.07 0.25 5.00
103 INT239087 Binding of SST and Negative_regulation of Localization of GH1 1 0.19 0.36 0.24 5.00
104 INT266421 Binding of HMGB1 and Il1 1 0.02 0.37 0.24 5.00
105 INT334390 ADIPOQ Positive_regulation of Localization of INS 1 0.09 1.3 0.23 5.00
106 INT266418 Binding of HMGB1 and Tlr4 1 0.09 0.37 0.23 5.00
107 INT298876 RAB7A Positive_regulation of Protein_catabolism of NTRK1 1 0.14 0.44 0.22 5.00
108 INT238802 Binding of Ager and Renbp 6 0.02 6.46 0.22 5.00
109 INT311872 IGHE Positive_regulation of Localization of Mmp9 1 0.01 1.35 0.22 5.00
110 INT266405 S100b Positive_regulation of Gene_expression of TFAM 1 0.00 1.02 0.21 5.00
111 INT266380 Binding of Tlr2 and Il1 1 0.01 0.76 0.21 5.00
112 INT266401 S100b Positive_regulation of S100b Positive_regulation of Ager 1 0.01 0.96 0.21 5.00
113 INT266423 Binding of HMGB1 and Mapk3 1 0.04 0.9 0.2 5.00
114 INT266410 Binding of HMGB1 and Mapk14 1 0.03 0.91 0.2 5.00
115 INT266416 Binding of HMGB1 and Mapk1 1 0.06 0.9 0.2 5.00
116 INT266414 Binding of HMGB1 and Mapk8 1 0.03 0.91 0.2 5.00
117 INT266404 Binding of HMGB1 and Thbd 1 0.06 0.3 0.2 5.00
118 INT206089 Negative_regulation of FOSB Negative_regulation of Gene_expression of PTGS2 1 0.00 0.97 0.19 5.00
119 INT334394 ADIPOQ Negative_regulation of Gene_expression of Tnf 1 0.37 1.06 0.18 5.00
120 INT319381 Binding of ST2 and IL33 1 0.13 1.01 0.18 5.00
121 INT206081 IL6ST Negative_regulation of IL6 1 0.11 0.81 0.17 5.00
122 INT266417 Binding of TGM2 and S100a11 1 0.01 0.86 0.16 5.00
123 INT266422 HMGB1 Positive_regulation of Binding of Ager 1 0.01 0.92 0.16 5.00
124 INT206059 IL6 Positive_regulation of INS 1 0.02 1.16 0.16 5.00
125 INT206070 ANG Positive_regulation of Transcription of IL6 1 0.05 1.5 0.15 5.00
126 INT266412 Binding of S100A12 and Ager 1 0.01 1.03 0.15 5.00
127 INT266377 Binding of S100a11 and Trp53 1 0.02 0.89 0.15 5.00
128 INT213749 NHS Positive_regulation of Localization of CALM1 1 0.28 0.58 0.14 5.00
129 INT237442 Ass1 Positive_regulation of S100b 1 0.00 0.18 0.13 5.00
130 INT215010 Myoz1 Positive_regulation of Gene_expression of Il2 1 0.05 0.13 0.13 5.00
131 INT266403 Negative_regulation of Binding of S100P and Ager 1 0.00 0.74 0.13 5.00
132 INT206065 EDN1 Positive_regulation of IL6 1 0.03 0.47 0.12 5.00
133 INT311871 Cav1 Regulation of Mch 1 0.01 0.24 0.11 5.00
134 INT266384 Binding of Ager and S100a6 1 0.01 1.32 0.11 5.00
135 INT283539 Binding of Litaf and Mad2l1bp 1 0.00 0.67 0.11 5.00
136 INT266386 Binding of S100a1 and Trp53 1 0.03 0.64 0.1 5.00
137 INT206056 PTK2B Negative_regulation of Positive_regulation of IRF6 1 0.00 0.66 0.1 5.00
138 INT284552 Binding of Cd8a and Mthfd1 2 0.03 1.32 0.1 5.00
139 INT266396 Binding of Ager and S100a4 1 0.01 0.59 0.1 5.00
140 INT206042 Negative_regulation of FDPS Negative_regulation of Binding of FDPS and GGPS1 1 0.00 0 0.09 5.00
141 INT199667 Cep290 Regulation of Atf4 1 0.04 1.96 0.09 5.00
142 INT206054 RAC1 Positive_regulation of STAT3 1 0.07 0.11 0.09 5.00
143 INT206075 Negative_regulation of FDPS Negative_regulation of Binding of GGPS1 1 0.01 0 0.09 5.00
144 INT215007 Car2 Regulation of Gene_expression of Trpv6 1 0.07 0.25 0.09 5.00
145 INT206078 Binding of FDPS and GGPS1 1 0.00 0 0.09 5.00
146 INT199666 Cntln Regulation of Atf4 1 0.00 1.95 0.09 5.00
147 INT206072 ANG Positive_regulation of IL6 1 0.05 0.5 0.08 5.00
148 INT266394 Binding of S100a4 and Trp53 1 0.03 0.59 0.08 5.00
149 INT266389 Binding of C2 and S100a6 1 0.04 0.5 0.07 5.00
150 INT266390 Binding of S100a6 and Trp53 1 0.04 0.51 0.07 5.00
151 INT268024 Binding of Abcc8 and Kcnj5 2 0.14 0 0.07 5.00
152 INT206080 ANG Regulation of Gene_expression of IL6 1 0.03 0.4 0.07 5.00
153 INT203419 Binding of EIF4A1 and Gtf3a 1 0.00 0.5 0.07 5.00
154 INT206063 ANG Positive_regulation of Gene_expression of KRT20 1 0.00 1.01 0.07 5.00
155 INT297230 Binding of Abcc8 and Fig4 1 0.10 0 0.07 5.00
156 INT266398 Binding of S100b and Trp53 1 0.06 0.92 0.07 5.00
157 INT234802 Binding of AQP2 and AVPR2 2 0.15 0.84 0.07 5.00
158 INT215006 Myoz1 Regulation of Transcription of Il2 1 0.06 0.44 0.06 5.00
159 INT266388 S100a6 Negative_regulation of Mapk8 1 0.03 0.49 0.06 5.00
160 INT266374 Binding of S100a1 and S100a9 1 0.09 0.17 0.05 5.00
161 INT237351 Binding of Mtm1 and Gopc 1 0.19 0.17 0.05 5.00
162 INT206087 RAC1 Positive_regulation of Gene_expression of STAT3 1 0.08 0.05 0.05 5.00
163 INT266387 Binding of S100a1 and S100a8 1 0.09 0.17 0.05 5.00
164 INT206083 LDLR Positive_regulation of Binding of STAT3 1 0.02 0.53 0.04 5.00
165 INT319384 Binding of AR and SCGB2A2 1 0.01 1.36 0.04 5.00
166 INT206073 Negative_regulation of RAC1 Positive_regulation of IL6 1 0.14 0.06 0.04 5.00
167 INT206067 Gene_expression of RAC1 Positive_regulation of Positive_regulation of IL6 1 0.16 0.07 0.04 5.00
168 INT266379 S100a8 Positive_regulation of Ager 1 0.01 0.3 0.04 5.00
169 INT266372 Binding of S100a1 and S100a4 1 0.11 0.15 0.04 5.00
170 INT290877 Binding of Bcl2a1c and Lepr 1 0.00 0.87 0.04 5.00
171 INT206068 RAC1 Positive_regulation of IL6 1 0.16 0.06 0.04 5.00
172 INT206066 LDLR Positive_regulation of Phosphorylation of STAT3 1 0.02 0.52 0.04 5.00
173 INT266392 S100a9 Positive_regulation of Ager 1 0.01 0.3 0.04 5.00
174 INT172902 Binding of Bax and Bcl2 5 0.30 3.19 0.03 5.00
175 INT206071 IRF6 Positive_regulation of Positive_regulation of IL1B 1 0.00 0.58 0.03 5.00
176 INT319382 Binding of IL13 and CRISP3 1 0.09 0.87 0.03 5.00
177 INT206076 IL6 Positive_regulation of Positive_regulation of STAT3 1 0.19 0.3 0.03 5.00
178 INT298831 Binding of MTOR and RAB7A Positive_regulation of MTOR 1 0.02 0.35 0.03 5.00
179 INT298878 Binding of MTOR and RAB7A 1 0.07 0.35 0.03 5.00
180 INT243766 Binding of Egr1 and Proc 1 0.01 0.2 0.03 5.00
181 INT206061 RAC1 Positive_regulation of Positive_regulation of STAT3 1 0.07 0.43 0.03 5.00
182 INT311870 Positive_regulation of Binding of Cd8a and Mthfd1 1 0.00 0.32 0.03 5.00
183 INT199665 Binding of Fxn and Lamtor3 1 0.00 0.16 0.03 5.00
184 INT266415 Binding of ROS1 and S100a6 1 0.02 0.82 0.03 5.00
185 INT298858 Positive_regulation of Binding of VAPA and RILP 1 0.07 0.54 0 5.00
186 INT298854 Binding of LAMP2 and RAB7A 1 0.16 0.56 0 5.00
187 INT174532 PTH Positive_regulation of Transcription of IGF1 1 0.06 0.51 0 5.00
188 INT298862 Binding of MCC and VPS13C 1 0.00 0.36 0 5.00
189 INT283001 Binding of Becn1 and Om 1 0.00 0.1 0 5.00
190 INT298879 Binding of MCC and MTG1 1 0.00 0.37 0 5.00
191 INT243768 Egr2 Regulation of Gene_expression of Nab2 1 0.47 0.14 0 5.00
192 INT215008 Gopc Positive_regulation of Myoz1 1 0.01 0.14 0 5.00
193 INT206085 FDPS Positive_regulation of AGFG1 1 0.00 0.4 0 5.00
194 INT206058 EGFR Negative_regulation of Gene_expression of IL6 1 0.07 0.62 0 5.00
195 INT298863 Binding of VAPB and RILP 1 0.13 0.21 0 5.00
196 INT206079 ANG Regulation of KRT20 1 0.00 0.54 0 5.00
197 INT206069 ANG Positive_regulation of Gene_expression of IL6 1 0.05 0.51 0 5.00
198 INT282995 Binding of Bcl2 and Becn1 21 0.03 9.8 0 5.00
199 INT243767 Egr2 Regulation of Gene_expression of Nab1 1 0.63 0.14 0 5.00
200 INT298875 Binding of RAB7A and VPS13C 1 0.21 0.49 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Charcot Marie Tooth Disease. They are ordered first by their pain relevance and then by number of times they were reported in Charcot Marie Tooth Disease. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT114330 Binding of MPZ 21 0.32 25.58 2.14 100.00
2 INT264689 Negative_regulation of IGFALS 10 0.33 12.58 0.45 100.00
3 INT91099 Gene_expression of MFN2 2 0.67 1.32 0.07 100.00
4 INT91101 Gene_expression of GARS 1 0.32 0.95 0.07 100.00
5 INT240278 Localization of IGFALS 11 0.53 9.44 0.29 100.00
6 INT297224 Negative_regulation of Negative_regulation of Kcnj5 1 0.11 0.74 0.27 99.48
7 INT67253 Gene_expression of Pmp22 4 0.33 6.48 1.79 99.42
8 INT148293 Positive_regulation of Gene_expression of Pmp22 1 0.30 1.58 0.92 99.42
9 INT194327 Positive_regulation of GDAP1 1 0.35 0.68 0 99.40
10 INT49082 Gene_expression of MPZ 15 0.65 31.26 2.24 99.00
11 INT164248 Positive_regulation of MPZ 18 0.67 24.54 2.16 98.92
12 INT57882 Negative_regulation of Kcnj5 33 0.35 13.06 12.27 98.76
13 INT114911 Positive_regulation of Mpz 3 0.23 1.46 0.8 98.72
14 INT91100 Binding of SPTLC1 10 0.47 12.85 5.71 98.64
15 INT82876 Regulation of IFNAR1 6 0.26 6.69 3.73 98.60
16 INT175214 Gene_expression of HSPB2 21 0.72 22.84 0.81 98.20
17 INT214999 Positive_regulation of Gene_expression of Myoz1 12 0.12 1.42 0.85 98.04
18 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 98.00
19 INT4931 Localization of IFNG 53 0.78 33.25 13.65 97.96
20 INT4929 Binding of Mbp 25 0.48 18.01 9.41 97.88
21 INT4928 Binding of Mag 9 0.26 7.62 1.42 97.88
22 INT144380 Gene_expression of SYNE1 12 0.58 6.99 1.55 97.72
23 INT105535 Gene_expression of Myoz1 27 0.13 3.94 1.5 97.68
24 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 96.48
25 INT298884 Binding of RAB7A 1 0.45 9.82 0.14 96.36
26 INT201261 Regulation of AGFG1 4 0.09 2.72 0.9 96.36
27 INT51444 Regulation of PMP22 2 0.44 1.39 0.07 96.28
28 INT109633 Negative_regulation of TP53INP2 5 0.15 2.29 6.46 95.68
29 INT217097 Regulation of Egr2 3 0.62 1.4 0.29 95.16
30 INT62688 Binding of Wnk1 2 0.17 2.83 0.63 95.12
31 INT30885 Positive_regulation of Nefl 6 0.36 6.99 0.9 94.60
32 INT156301 Regulation of Trpv4 11 0.60 2.81 2.35 94.48
33 INT81955 Positive_regulation of SPTLC1 12 0.70 10.25 3.12 94.20
34 INT83411 Binding of Ntrk1 6 0.19 3.7 3.74 94.16
35 INT51445 Binding of B3GAT1 9 0.47 4.64 3.95 94.00
36 INT224365 Positive_regulation of Gene_expression of Ager 13 0.69 11.6 0.88 93.72
37 INT245577 Localization of SFTPD 7 0.63 10.43 1.84 93.68
38 INT163998 Gene_expression of CTSC 9 0.65 11.24 1.69 93.32
39 INT224366 Gene_expression of Ager 111 0.77 125.37 8.49 93.32
40 INT34778 Localization of IGF2 5 0.62 4.78 0.59 93.32
41 INT160251 Gene_expression of Myo5a 48 0.63 37.14 3.16 93.08
42 INT57163 Gene_expression of AGFG1 11 0.75 2.45 0.48 92.48
43 INT121918 Binding of Rab7 1 0.34 0.64 0.09 92.48
44 INT75938 Regulation of TP53INP2 9 0.09 2.45 7.21 92.44
45 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 92.00
46 INT217102 Gene_expression of Egr2 50 0.78 10.91 3.89 91.60
47 INT81553 Binding of PMP22 2 0.03 2.13 0 91.32
48 INT5148 Regulation of CD40LG 25 0.44 21.58 4.05 90.76
49 INT175225 Positive_regulation of Gene_expression of HSPB2 2 0.65 3.57 0.06 90.48
50 INT64965 Binding of AGFG1 8 0.10 3.53 0.45 90.24
51 INT30101 Regulation of Cacna1a 25 0.45 14.38 12.43 89.44
52 INT283541 Binding of GARS 1 0.01 3.33 0.04 89.40
53 INT17890 Negative_regulation of HMGCR 26 0.42 12.05 1.94 89.40
54 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 89.12
55 INT13108 Binding of MTG1 35 0.47 6.36 20.5 88.80
56 INT213672 Positive_regulation of LRFN2 1 0.01 0.59 0.03 88.64
57 INT85624 Gene_expression of GJB1 5 0.78 3.03 0.93 88.04
58 INT183832 Positive_regulation of TRHDE 1 0.16 0.09 0 87.68
59 INT213671 Positive_regulation of COX4I1 1 0.00 0.58 0.03 87.52
60 INT217094 Positive_regulation of Egr2 17 0.69 5.31 1.87 87.24
61 INT297217 Localization of Abcc8 1 0.74 1.21 1.18 87.24
62 INT253215 Gene_expression of Sh2b1 1 0.66 6.78 5.84 87.16
63 INT213669 Positive_regulation of COL4A3 2 0.00 1.24 0.23 87.04
64 INT297219 Negative_regulation of Abcc8 1 0.54 1.08 0.93 86.60
65 INT194332 Localization of MFN2 2 0.74 1.45 0.15 86.44
66 INT28817 Binding of TRPV4 6 0.39 3.92 2.59 86.20
67 INT132294 Positive_regulation of Sptlc1 3 0.31 3.84 0.14 85.44
68 INT238807 Localization of HSPB2 1 0.75 2.27 0.04 85.28
69 INT39060 Gene_expression of Mpz 45 0.77 21.55 4.3 85.00
70 INT308024 Negative_regulation of Icmt 1 0.06 0.59 0.05 84.52
71 INT16165 Regulation of DMD 114 0.60 35.13 3.64 84.28
72 INT88464 Negative_regulation of CST7 11 0.31 5.33 2.17 84.00
73 INT38673 Negative_regulation of KRT20 38 0.42 22.49 2.77 84.00
74 INT149384 Negative_regulation of TRPV4 4 0.43 2.41 1.23 83.64
75 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 82.96
76 INT73602 Positive_regulation of Ager 35 0.69 30.66 3.74 81.92
77 INT31598 Gene_expression of Mgst1 41 0.78 6.44 6.3 81.32
78 INT89167 Positive_regulation of Gene_expression of Mgst1 11 0.69 2.09 1.53 81.32
79 INT93094 Gene_expression of Bak1 13 0.52 13.94 1.02 81.32
80 INT140379 Positive_regulation of Gene_expression of Bak1 4 0.27 2.27 0.31 81.32
81 INT41296 Protein_catabolism of Oprd1 8 0.85 0.79 3.48 81.08
82 INT237340 Positive_regulation of Mtm1 1 0.60 1.52 0.14 80.64
83 INT77246 Positive_regulation of WNK1 5 0.10 4.24 1.13 80.56
84 INT59900 Binding of MATN3 13 0.42 17.19 3.59 80.32
85 INT21877 Negative_regulation of Serpind1 3 0.52 6.85 0.93 79.68
86 INT27096 Positive_regulation of Nfkb1 325 0.70 195.11 109.06 79.00
87 INT194331 Binding of MAD2L1BP 1 0.08 0.62 0.04 78.92
88 INT194329 Positive_regulation of MFN2 1 0.40 0.74 0.03 78.72
89 INT153496 Negative_regulation of Pmp22 2 0.42 3.34 0.26 78.64
90 INT237341 Binding of Mtm1 1 0.48 1.16 0.07 78.48
91 INT201259 Negative_regulation of RAB7A 2 0.41 2.45 0.54 78.28
92 INT80033 Binding of FAS 37 0.48 41.19 5.67 77.56
93 INT194330 Regulation of Gene_expression of MFN2 1 0.45 0.3 0 77.48
94 INT216107 Gene_expression of Imraq1 30 0.08 6.11 0.8 77.12
95 INT216106 Positive_regulation of Gene_expression of Imraq1 6 0.05 2 0.19 77.12
96 INT243753 Gene_expression of Egr4 1 0.74 0.46 0.22 77.12
97 INT243755 Gene_expression of Kcnh7 1 0.37 0.46 0.22 77.12
98 INT227102 Gene_expression of Mtm1 2 0.77 9.58 0.26 76.60
99 INT200185 Regulation of Igfals 10 0.26 11.4 1.47 76.56
100 INT211226 Regulation of Positive_regulation of Serpind1 1 0.38 1.99 0.2 75.96
101 INT226176 Protein_catabolism of Hmbs 15 0.61 13.17 0.56 75.80
102 INT211224 Positive_regulation of Serpind1 8 0.59 12.15 1.8 75.76
103 INT31616 Protein_catabolism of DNM2 5 0.75 1.61 1.63 75.36
104 INT329011 Protein_catabolism of RAB7A 1 0.07 1.06 0 75.36
105 INT329010 Protein_catabolism of LITAF 1 0.11 1.06 0 75.36
106 INT53015 Gene_expression of TP53INP2 50 0.78 9.05 26.23 75.36
107 INT28952 Negative_regulation of Gene_expression of IGF1 75 0.58 41.11 12.32 75.20
108 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 75.20
109 INT22605 Regulation of Pgr 22 0.62 7.1 2.26 75.00
110 INT139170 Negative_regulation of Gene_expression of Pmp22 1 0.37 0.83 0.09 75.00
111 INT139169 Gene_expression of Pmp22 10 0.68 8.37 2.5 75.00
112 INT61585 Gene_expression of NALCN 25 0.52 6.52 8.18 75.00
113 INT118232 Regulation of Gene_expression of NALCN 3 0.13 1.92 2.25 75.00
114 INT164512 Regulation of MPZ 12 0.30 8.38 1.53 75.00
115 INT164511 Negative_regulation of Binding of MPZ 2 0.36 1.64 0.29 75.00
116 INT308025 Positive_regulation of Gdap1 1 0.39 1.05 0.14 74.96
117 INT144198 Positive_regulation of HSPB2 7 0.48 5.66 0.11 74.96
118 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 74.76
119 INT188242 Negative_regulation of Positive_regulation of CRP 4 0.23 3.94 0.22 74.76
120 INT34741 Positive_regulation of Gene_expression of GH1 58 0.67 35.06 7.8 74.72
121 INT531 Gene_expression of GH1 376 0.75 193.45 46.24 74.32
122 INT955 Gene_expression of GHRH 126 0.78 59.91 20.74 74.32
123 INT12725 Positive_regulation of Racgap1 66 0.68 32.74 19.29 73.96
124 INT234814 Positive_regulation of AGFG1 6 0.10 2.33 0.07 73.96
125 INT96520 Gene_expression of PRPH 5 0.75 2.55 0.39 73.88
126 INT62681 Negative_regulation of LEP 93 0.59 66.97 15.77 73.76
127 INT188241 Negative_regulation of ADIPOQ 16 0.43 22.16 1.47 73.76
128 INT308023 Gene_expression of Gdap1 1 0.65 1.13 0.14 73.12
129 INT812 Localization of INS 1026 0.81 515.6 145.31 73.04
130 INT81550 Binding of Pmp22 4 0.35 4.2 0.49 72.76
131 INT234828 Gene_expression of RAB3A 2 0.30 2.05 0.37 72.44
132 INT203372 Positive_regulation of Igfals 10 0.40 9.24 1.11 72.20
133 INT158124 Gene_expression of COL5A2 136 0.69 72.3 12.44 71.92
134 INT174541 Positive_regulation of Gene_expression of COL5A2 18 0.36 14.17 2.12 71.92
135 INT229794 Positive_regulation of RAB7A 2 0.65 11.68 1.31 70.40
136 INT81551 Negative_regulation of Gene_expression of Pmp22 2 0.11 4.03 0.15 69.40
137 INT307658 Negative_regulation of Mfn2 1 0.42 0.45 0 69.32
138 INT297221 Negative_regulation of Gene_expression of Abcc8 1 0.39 0.58 0.08 68.96
139 INT33567 Gene_expression of CALM1 139 0.67 48.85 56.14 68.04
140 INT255451 Positive_regulation of Positive_regulation of APOB 2 0.37 1.91 0.05 67.68
141 INT153495 Binding of Pmp22 3 0.37 2.51 0.34 67.48
142 INT268043 Gene_expression of Abcc8 30 0.71 3.05 5.61 67.28
143 INT40877 Positive_regulation of APOB 35 0.68 32.47 1.86 67.28
144 INT38672 Binding of KRT20 69 0.39 48.01 6.31 66.84
145 INT237346 Localization of Mtm1 1 0.80 0.71 0.08 66.12
146 INT210272 Binding of Ccrs1 1 0.01 1.13 0 65.60
147 INT56912 Gene_expression of Nefm 4 0.33 2.75 0.8 64.16
148 INT203353 Negative_regulation of Gene_expression of Nefm 1 0.12 0.84 0 64.16
149 INT298923 Positive_regulation of Protein_catabolism of NTRK1 1 0.13 0.5 0.07 63.84
150 INT48313 Binding of NTRK1 19 0.47 14.44 6.12 63.84
151 INT298887 Protein_catabolism of NTRK1 1 0.25 1.1 0.56 63.84
152 INT89543 Gene_expression of NEFL 18 0.75 10.6 2.67 63.68
153 INT260445 Positive_regulation of QTRT1 1 0.01 0.25 0 63.32
154 INT147792 Gene_expression of COPD 230 0.70 287.13 24.1 63.20
155 INT283536 Binding of Setx 1 0.36 3.69 0 62.68
156 INT78226 Gene_expression of Mbp 43 0.75 22.14 7.79 62.28
157 INT108968 Regulation of Mpz 6 0.54 2.9 0.7 61.28
158 INT11805 Regulation of Gene_expression of Il2 19 0.62 6.62 5.2 61.04
159 INT153913 Positive_regulation of Lpar1 31 0.70 33.5 16.14 60.88
160 INT11807 Gene_expression of Il2 266 0.78 112 64.97 60.52
161 INT105960 Gene_expression of Cdh1 41 0.76 22.28 5.56 60.52
162 INT142740 Gene_expression of Trpv6 15 0.78 6.1 2.06 60.52
163 INT203361 Negative_regulation of Gene_expression of Tubb6 1 0.42 0.81 0 60.32
164 INT203351 Gene_expression of Tubb2a 2 0.69 2.01 0 60.32
165 INT203324 Gene_expression of Tubb6 1 0.55 0.81 0 60.32
166 INT203360 Negative_regulation of Gene_expression of Tubb2a 1 0.29 0.82 0 60.32
167 INT215000 Transcription of Cdh1 4 0.40 1.17 0.22 59.96
168 INT28673 Gene_expression of APOB 51 0.73 34.02 3.95 59.88
169 INT146197 Positive_regulation of Rhoa 60 0.68 34.12 12.02 59.48
170 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 59.36
171 INT11340 Positive_regulation of SLC17A5 120 0.67 113.52 14.5 59.36
172 INT11823 Positive_regulation of GGT1 53 0.67 45.84 7.55 59.36
173 INT288302 Positive_regulation of Phosphorylation of SLC17A5 1 0.49 2 0.24 59.36
174 INT288300 Positive_regulation of Phosphorylation of GGT1 1 0.49 1.94 0.21 59.36
175 INT288297 Positive_regulation of Phosphorylation of Crp 1 0.03 1.93 0.21 59.36
176 INT142743 Transcription of Trpv6 5 0.72 0.91 0.32 59.36
177 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 58.80
178 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 58.80
179 INT99690 Negative_regulation of Positive_regulation of VEGFA 30 0.58 14.56 4.79 58.80
180 INT206159 Negative_regulation of Regulation of VEGFA 3 0.24 2.38 0.2 58.80
181 INT203336 Regulation of Tubb6 1 0.09 0.81 0 57.60
182 INT298902 Positive_regulation of Protein_catabolism of GFM1 1 0.49 0.44 0.06 57.20
183 INT298907 Protein_catabolism of GFM1 1 0.86 0.22 0.03 57.20
184 INT87573 Phosphorylation of Crp 2 0.05 1.99 0.21 57.20
185 INT203319 Regulation of Tubb2a 1 0.19 0.8 0 57.04
186 INT117893 Binding of Serpind1 15 0.41 24.59 2.41 57.00
187 INT302703 Binding of PLAA 1 0.13 0.87 0.15 56.32
188 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 56.04
189 INT162624 Regulation of Mag 9 0.44 8.28 4.28 55.88
190 INT194901 Regulation of Nfasc 8 0.21 5.76 1.15 55.80
191 INT181781 Positive_regulation of FOSB 6 0.39 4.77 0.34 55.12
192 INT206146 Negative_regulation of Positive_regulation of FOSB 2 0.26 1.14 0.11 55.12
193 INT329009 Phosphorylation of MPZ 1 0.04 0.29 0 54.68
194 INT159489 Positive_regulation of Positive_regulation of Csf2 6 0.42 6.02 1.61 54.56
195 INT237441 Positive_regulation of Positive_regulation of S100b 2 0.36 3 0.12 54.56
196 INT70970 Binding of COPD 144 0.42 180.34 18.29 54.48
197 INT288301 Phosphorylation of SLC17A5 1 0.79 1.8 0.23 54.36
198 INT288303 Phosphorylation of GGT1 1 0.79 1.74 0.2 54.36
199 INT92835 Gene_expression of Col4a1 22 0.49 13.5 2.27 54.28
200 INT297225 Negative_regulation of Localization of Kcnj5 1 0.11 0.58 0.09 53.92
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